-- dump date 20140619_122147 -- class Genbank::misc_feature -- table misc_feature_note -- id note 478801000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478801000002 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 478801000003 Walker A motif; other site 478801000004 ATP binding site [chemical binding]; other site 478801000005 Walker B motif; other site 478801000006 arginine finger; other site 478801000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 478801000008 DnaA box-binding interface [nucleotide binding]; other site 478801000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 478801000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 478801000011 putative DNA binding surface [nucleotide binding]; other site 478801000012 dimer interface [polypeptide binding]; other site 478801000013 beta-clamp/clamp loader binding surface; other site 478801000014 beta-clamp/translesion DNA polymerase binding surface; other site 478801000015 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 478801000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 478801000017 recombination protein F; Reviewed; Region: recF; PRK00064 478801000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 478801000019 Walker A/P-loop; other site 478801000020 ATP binding site [chemical binding]; other site 478801000021 Q-loop/lid; other site 478801000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801000023 ABC transporter signature motif; other site 478801000024 Walker B; other site 478801000025 D-loop; other site 478801000026 H-loop/switch region; other site 478801000027 Protein of unknown function (DUF721); Region: DUF721; cl02324 478801000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 478801000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478801000030 Mg2+ binding site [ion binding]; other site 478801000031 G-X-G motif; other site 478801000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 478801000033 anchoring element; other site 478801000034 dimer interface [polypeptide binding]; other site 478801000035 ATP binding site [chemical binding]; other site 478801000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 478801000037 active site 478801000038 putative metal-binding site [ion binding]; other site 478801000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 478801000040 DNA gyrase subunit A; Validated; Region: PRK05560 478801000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 478801000042 CAP-like domain; other site 478801000043 active site 478801000044 primary dimer interface [polypeptide binding]; other site 478801000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 478801000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 478801000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 478801000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 478801000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 478801000050 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 478801000051 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 478801000052 active site 478801000053 Rhomboid family; Region: Rhomboid; pfam01694 478801000054 Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506 478801000055 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 478801000056 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 478801000057 Catalytic domain of Protein Kinases; Region: PKc; cd00180 478801000058 active site 478801000059 ATP binding site [chemical binding]; other site 478801000060 substrate binding site [chemical binding]; other site 478801000061 activation loop (A-loop); other site 478801000062 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 478801000063 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 478801000064 Catalytic domain of Protein Kinases; Region: PKc; cd00180 478801000065 active site 478801000066 ATP binding site [chemical binding]; other site 478801000067 substrate binding site [chemical binding]; other site 478801000068 activation loop (A-loop); other site 478801000069 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 478801000070 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 478801000071 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 478801000072 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 478801000073 Protein phosphatase 2C; Region: PP2C; pfam00481 478801000074 active site 478801000075 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 478801000076 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 478801000077 phosphopeptide binding site; other site 478801000078 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 478801000079 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 478801000080 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 478801000081 phosphopeptide binding site; other site 478801000082 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 478801000083 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 478801000084 Pirin-related protein [General function prediction only]; Region: COG1741 478801000085 Pirin; Region: Pirin; pfam02678 478801000086 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 478801000087 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 478801000088 Glutaminase; Region: Glutaminase; cl00907 478801000089 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 478801000090 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 478801000091 ligand binding site [chemical binding]; other site 478801000092 flexible hinge region; other site 478801000093 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 478801000094 hydrophobic ligand binding site; other site 478801000095 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 478801000096 classical (c) SDRs; Region: SDR_c; cd05233 478801000097 NAD(P) binding site [chemical binding]; other site 478801000098 active site 478801000099 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 478801000100 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 478801000101 NAD binding site [chemical binding]; other site 478801000102 catalytic Zn binding site [ion binding]; other site 478801000103 structural Zn binding site [ion binding]; other site 478801000104 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 478801000105 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 478801000106 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 478801000107 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 478801000108 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 478801000109 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 478801000110 putative active site [active] 478801000111 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 478801000112 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 478801000113 Transcriptional regulators [Transcription]; Region: GntR; COG1802 478801000114 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 478801000115 DNA-binding site [nucleotide binding]; DNA binding site 478801000116 FCD domain; Region: FCD; pfam07729 478801000117 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 478801000118 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 478801000119 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 478801000120 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 478801000121 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478801000122 active site 478801000123 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 478801000124 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 478801000125 hydroperoxidase II; Provisional; Region: katE; PRK11249 478801000126 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 478801000127 heme binding pocket [chemical binding]; other site 478801000128 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 478801000129 conserved cys residue [active] 478801000130 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 478801000131 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 478801000132 malonyl-CoA binding site [chemical binding]; other site 478801000133 dimer interface [polypeptide binding]; other site 478801000134 active site 478801000135 product binding site; other site 478801000136 Phospholipid methyltransferase; Region: PEMT; cl17370 478801000137 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 478801000138 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 478801000139 Sulphur transport; Region: Sulf_transp; pfam04143 478801000140 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 478801000141 CPxP motif; other site 478801000142 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 478801000143 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 478801000144 Walker A/P-loop; other site 478801000145 ATP binding site [chemical binding]; other site 478801000146 Q-loop/lid; other site 478801000147 ABC transporter signature motif; other site 478801000148 Walker B; other site 478801000149 D-loop; other site 478801000150 H-loop/switch region; other site 478801000151 TOBE domain; Region: TOBE_2; pfam08402 478801000152 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 478801000153 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 478801000154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801000155 putative substrate translocation pore; other site 478801000156 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 478801000157 RNase_H superfamily; Region: RNase_H_2; pfam13482 478801000158 Part of AAA domain; Region: AAA_19; pfam13245 478801000159 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 478801000160 AAA domain; Region: AAA_12; pfam13087 478801000161 malate dehydrogenase; Provisional; Region: PRK13529 478801000162 Malic enzyme, N-terminal domain; Region: malic; pfam00390 478801000163 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 478801000164 NAD(P) binding pocket [chemical binding]; other site 478801000165 Src Homology 3 domain superfamily; Region: SH3; cl17036 478801000166 peptide ligand binding site [polypeptide binding]; other site 478801000167 Src Homology 3 domain superfamily; Region: SH3; cl17036 478801000168 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 478801000169 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478801000170 MULE transposase domain; Region: MULE; pfam10551 478801000171 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 478801000172 putative dimer interface [polypeptide binding]; other site 478801000173 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478801000174 ligand binding site [chemical binding]; other site 478801000175 Zn binding site [ion binding]; other site 478801000176 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 478801000177 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 478801000178 heme-binding site [chemical binding]; other site 478801000179 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 478801000180 FAD binding pocket [chemical binding]; other site 478801000181 FAD binding motif [chemical binding]; other site 478801000182 phosphate binding motif [ion binding]; other site 478801000183 beta-alpha-beta structure motif; other site 478801000184 NAD binding pocket [chemical binding]; other site 478801000185 Heme binding pocket [chemical binding]; other site 478801000186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478801000187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478801000188 NAD(P) binding site [chemical binding]; other site 478801000189 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 478801000190 active site 478801000191 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 478801000192 active site pocket [active] 478801000193 oxyanion hole [active] 478801000194 catalytic triad [active] 478801000195 active site nucleophile [active] 478801000196 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 478801000197 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 478801000198 active site 478801000199 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 478801000200 substrate binding site [chemical binding]; other site 478801000201 catalytic residues [active] 478801000202 dimer interface [polypeptide binding]; other site 478801000203 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 478801000204 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 478801000205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478801000206 homodimer interface [polypeptide binding]; other site 478801000207 catalytic residue [active] 478801000208 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 478801000209 dihydrodipicolinate synthase; Region: dapA; TIGR00674 478801000210 dimer interface [polypeptide binding]; other site 478801000211 active site 478801000212 catalytic residue [active] 478801000213 dihydrodipicolinate reductase; Provisional; Region: PRK00048 478801000214 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 478801000215 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 478801000216 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 478801000217 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 478801000218 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 478801000219 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 478801000220 active site 478801000221 catalytic residue [active] 478801000222 dimer interface [polypeptide binding]; other site 478801000223 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 478801000224 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 478801000225 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 478801000226 BCCT family transporter; Region: BCCT; pfam02028 478801000227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801000228 putative substrate translocation pore; other site 478801000229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801000230 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 478801000231 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 478801000232 DNA binding residues [nucleotide binding] 478801000233 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 478801000234 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 478801000235 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 478801000236 nucleoside/Zn binding site; other site 478801000237 dimer interface [polypeptide binding]; other site 478801000238 catalytic motif [active] 478801000239 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 478801000240 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 478801000241 catalytic residues [active] 478801000242 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 478801000243 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 478801000244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478801000245 active site 478801000246 phosphorylation site [posttranslational modification] 478801000247 intermolecular recognition site; other site 478801000248 dimerization interface [polypeptide binding]; other site 478801000249 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 478801000250 DNA binding residues [nucleotide binding] 478801000251 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 478801000252 Histidine kinase; Region: HisKA_3; pfam07730 478801000253 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 478801000254 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 478801000255 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 478801000256 Walker A/P-loop; other site 478801000257 ATP binding site [chemical binding]; other site 478801000258 Q-loop/lid; other site 478801000259 ABC transporter signature motif; other site 478801000260 Walker B; other site 478801000261 D-loop; other site 478801000262 H-loop/switch region; other site 478801000263 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 478801000264 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 478801000265 NADP binding site [chemical binding]; other site 478801000266 dimer interface [polypeptide binding]; other site 478801000267 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 478801000268 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 478801000269 putative NAD(P) binding site [chemical binding]; other site 478801000270 putative active site [active] 478801000271 PhoD-like phosphatase; Region: PhoD; pfam09423 478801000272 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 478801000273 putative active site [active] 478801000274 putative metal binding site [ion binding]; other site 478801000275 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 478801000276 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 478801000277 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 478801000278 acyl-activating enzyme (AAE) consensus motif; other site 478801000279 putative AMP binding site [chemical binding]; other site 478801000280 putative active site [active] 478801000281 putative CoA binding site [chemical binding]; other site 478801000282 acetyl-CoA synthetase; Provisional; Region: PRK00174 478801000283 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 478801000284 active site 478801000285 CoA binding site [chemical binding]; other site 478801000286 acyl-activating enzyme (AAE) consensus motif; other site 478801000287 AMP binding site [chemical binding]; other site 478801000288 acetate binding site [chemical binding]; other site 478801000289 MMPL family; Region: MMPL; pfam03176 478801000290 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 478801000291 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478801000292 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 478801000293 acyl-activating enzyme (AAE) consensus motif; other site 478801000294 putative AMP binding site [chemical binding]; other site 478801000295 putative active site [active] 478801000296 putative CoA binding site [chemical binding]; other site 478801000297 Uncharacterized conserved protein [Function unknown]; Region: COG4850 478801000298 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 478801000299 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 478801000300 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 478801000301 putative DNA binding site [nucleotide binding]; other site 478801000302 catalytic residue [active] 478801000303 putative H2TH interface [polypeptide binding]; other site 478801000304 putative catalytic residues [active] 478801000305 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 478801000306 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 478801000307 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 478801000308 active site residue [active] 478801000309 AAA ATPase domain; Region: AAA_16; pfam13191 478801000310 Major Facilitator Superfamily; Region: MFS_1; pfam07690 478801000311 Transcriptional regulator [Transcription]; Region: LysR; COG0583 478801000312 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 478801000313 Helix-turn-helix domain; Region: HTH_17; pfam12728 478801000314 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478801000315 Coenzyme A binding pocket [chemical binding]; other site 478801000316 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 478801000317 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 478801000318 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 478801000319 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 478801000320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801000321 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478801000322 dimerization interface [polypeptide binding]; other site 478801000323 putative DNA binding site [nucleotide binding]; other site 478801000324 putative Zn2+ binding site [ion binding]; other site 478801000325 CAAX protease self-immunity; Region: Abi; pfam02517 478801000326 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 478801000327 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 478801000328 DNA binding residues [nucleotide binding] 478801000329 dimer interface [polypeptide binding]; other site 478801000330 [2Fe-2S] cluster binding site [ion binding]; other site 478801000331 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 478801000332 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 478801000333 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801000334 ABC transporter signature motif; other site 478801000335 Walker B; other site 478801000336 D-loop; other site 478801000337 H-loop/switch region; other site 478801000338 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 478801000339 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 478801000340 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801000341 Walker A/P-loop; other site 478801000342 ATP binding site [chemical binding]; other site 478801000343 Q-loop/lid; other site 478801000344 ABC transporter signature motif; other site 478801000345 Walker B; other site 478801000346 D-loop; other site 478801000347 H-loop/switch region; other site 478801000348 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 478801000349 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 478801000350 dimer interface [polypeptide binding]; other site 478801000351 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 478801000352 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 478801000353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 478801000354 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478801000355 putative DNA binding site [nucleotide binding]; other site 478801000356 putative Zn2+ binding site [ion binding]; other site 478801000357 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478801000358 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 478801000359 dimer interface [polypeptide binding]; other site 478801000360 putative metal binding site [ion binding]; other site 478801000361 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 478801000362 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 478801000363 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 478801000364 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478801000365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 478801000366 Coenzyme A binding pocket [chemical binding]; other site 478801000367 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478801000368 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 478801000369 active site 478801000370 hypothetical protein; Provisional; Region: PRK06753 478801000371 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 478801000372 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 478801000373 TPR motif; other site 478801000374 Tetratrico peptide repeat; Region: TPR_5; pfam12688 478801000375 binding surface 478801000376 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 478801000377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478801000378 Methyltransferase domain; Region: Methyltransf_31; pfam13847 478801000379 S-adenosylmethionine binding site [chemical binding]; other site 478801000380 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 478801000381 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 478801000382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478801000383 S-adenosylmethionine binding site [chemical binding]; other site 478801000384 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 478801000385 catalytic nucleophile [active] 478801000386 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 478801000387 active site 478801000388 Beta-lactamase; Region: Beta-lactamase; pfam00144 478801000389 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478801000390 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 478801000391 catalytic residues [active] 478801000392 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 478801000393 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 478801000394 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 478801000395 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 478801000396 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 478801000397 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478801000398 substrate binding site [chemical binding]; other site 478801000399 oxyanion hole (OAH) forming residues; other site 478801000400 trimer interface [polypeptide binding]; other site 478801000401 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 478801000402 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 478801000403 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 478801000404 catalytic motif [active] 478801000405 Zn binding site [ion binding]; other site 478801000406 RibD C-terminal domain; Region: RibD_C; pfam01872 478801000407 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 478801000408 Lumazine binding domain; Region: Lum_binding; pfam00677 478801000409 Lumazine binding domain; Region: Lum_binding; pfam00677 478801000410 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 478801000411 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 478801000412 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 478801000413 dimerization interface [polypeptide binding]; other site 478801000414 active site 478801000415 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 478801000416 homopentamer interface [polypeptide binding]; other site 478801000417 active site 478801000418 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 478801000419 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478801000420 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478801000421 active site 478801000422 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 478801000423 active site 478801000424 barstar interaction site; other site 478801000425 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 478801000426 RNAase interaction site [polypeptide binding]; other site 478801000427 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 478801000428 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 478801000429 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 478801000430 seryl-tRNA synthetase; Provisional; Region: PRK05431 478801000431 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 478801000432 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 478801000433 dimer interface [polypeptide binding]; other site 478801000434 active site 478801000435 motif 1; other site 478801000436 motif 2; other site 478801000437 motif 3; other site 478801000438 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 478801000439 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478801000440 active site 478801000441 motif I; other site 478801000442 motif II; other site 478801000443 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478801000444 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 478801000445 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 478801000446 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 478801000447 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 478801000448 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 478801000449 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478801000450 BioY family; Region: BioY; pfam02632 478801000451 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 478801000452 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 478801000453 Walker A/P-loop; other site 478801000454 ATP binding site [chemical binding]; other site 478801000455 Q-loop/lid; other site 478801000456 ABC transporter signature motif; other site 478801000457 Walker B; other site 478801000458 D-loop; other site 478801000459 H-loop/switch region; other site 478801000460 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 478801000461 short chain dehydrogenase; Provisional; Region: PRK08309 478801000462 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 478801000463 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 478801000464 DNA binding residues [nucleotide binding] 478801000465 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478801000466 MULE transposase domain; Region: MULE; pfam10551 478801000467 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 478801000468 Divergent AAA domain; Region: AAA_4; pfam04326 478801000469 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 478801000470 adenylosuccinate lyase; Provisional; Region: PRK09285 478801000471 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 478801000472 tetramer interface [polypeptide binding]; other site 478801000473 active site 478801000474 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 478801000475 Penicillinase repressor; Region: Pencillinase_R; pfam03965 478801000476 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 478801000477 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801000478 Walker A/P-loop; other site 478801000479 ATP binding site [chemical binding]; other site 478801000480 Q-loop/lid; other site 478801000481 ABC transporter signature motif; other site 478801000482 Walker B; other site 478801000483 D-loop; other site 478801000484 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801000485 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 478801000486 Walker A/P-loop; other site 478801000487 ATP binding site [chemical binding]; other site 478801000488 Q-loop/lid; other site 478801000489 ABC transporter signature motif; other site 478801000490 Walker B; other site 478801000491 D-loop; other site 478801000492 H-loop/switch region; other site 478801000493 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 478801000494 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 478801000495 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 478801000496 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 478801000497 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 478801000498 CoenzymeA binding site [chemical binding]; other site 478801000499 subunit interaction site [polypeptide binding]; other site 478801000500 PHB binding site; other site 478801000501 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 478801000502 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 478801000503 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 478801000504 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 478801000505 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 478801000506 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 478801000507 NAD(P) binding site [chemical binding]; other site 478801000508 catalytic residues [active] 478801000509 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478801000510 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801000511 Walker A/P-loop; other site 478801000512 ATP binding site [chemical binding]; other site 478801000513 Q-loop/lid; other site 478801000514 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 478801000515 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 478801000516 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801000517 Walker A/P-loop; other site 478801000518 ATP binding site [chemical binding]; other site 478801000519 Q-loop/lid; other site 478801000520 ABC transporter signature motif; other site 478801000521 Walker B; other site 478801000522 D-loop; other site 478801000523 H-loop/switch region; other site 478801000524 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 478801000525 active site 478801000526 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 478801000527 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 478801000528 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 478801000529 Serine hydrolase; Region: Ser_hydrolase; cl17834 478801000530 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 478801000531 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 478801000532 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 478801000533 hydrophobic ligand binding site; other site 478801000534 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 478801000535 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478801000536 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 478801000537 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 478801000538 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478801000539 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 478801000540 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478801000541 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478801000542 WHG domain; Region: WHG; pfam13305 478801000543 Protein of unknown function (DUF664); Region: DUF664; pfam04978 478801000544 DinB superfamily; Region: DinB_2; pfam12867 478801000545 H+ Antiporter protein; Region: 2A0121; TIGR00900 478801000546 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478801000547 dimerization interface [polypeptide binding]; other site 478801000548 putative DNA binding site [nucleotide binding]; other site 478801000549 putative Zn2+ binding site [ion binding]; other site 478801000550 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 478801000551 nudix motif; other site 478801000552 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 478801000553 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 478801000554 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 478801000555 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478801000556 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 478801000557 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478801000558 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 478801000559 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478801000560 catalytic residue [active] 478801000561 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 478801000562 putative active site [active] 478801000563 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 478801000564 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 478801000565 amphipathic channel; other site 478801000566 Asn-Pro-Ala signature motifs; other site 478801000567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478801000568 S-adenosylmethionine binding site [chemical binding]; other site 478801000569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 478801000570 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 478801000571 Major Facilitator Superfamily; Region: MFS_1; pfam07690 478801000572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801000573 Pirin-related protein [General function prediction only]; Region: COG1741 478801000574 Pirin; Region: Pirin; pfam02678 478801000575 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 478801000576 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 478801000577 active site 478801000578 Low molecular weight phosphatase family; Region: LMWPc; cd00115 478801000579 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 478801000580 active site 478801000581 Fructosamine kinase; Region: Fructosamin_kin; cl17579 478801000582 Phosphotransferase enzyme family; Region: APH; pfam01636 478801000583 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 478801000584 active site 478801000585 catalytic residues [active] 478801000586 Predicted membrane protein [Function unknown]; Region: COG1950 478801000587 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 478801000588 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 478801000589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478801000590 homodimer interface [polypeptide binding]; other site 478801000591 catalytic residue [active] 478801000592 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 478801000593 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 478801000594 TPP-binding site [chemical binding]; other site 478801000595 heterodimer interface [polypeptide binding]; other site 478801000596 tetramer interface [polypeptide binding]; other site 478801000597 phosphorylation loop region [posttranslational modification] 478801000598 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 478801000599 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 478801000600 alpha subunit interface [polypeptide binding]; other site 478801000601 TPP binding site [chemical binding]; other site 478801000602 heterodimer interface [polypeptide binding]; other site 478801000603 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 478801000604 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 478801000605 E3 interaction surface; other site 478801000606 lipoyl attachment site [posttranslational modification]; other site 478801000607 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 478801000608 E3 interaction surface; other site 478801000609 lipoyl attachment site [posttranslational modification]; other site 478801000610 e3 binding domain; Region: E3_binding; pfam02817 478801000611 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 478801000612 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 478801000613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801000614 Major Facilitator Superfamily; Region: MFS_1; pfam07690 478801000615 putative substrate translocation pore; other site 478801000616 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478801000617 active site 478801000618 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 478801000619 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478801000620 active site 478801000621 AMP binding site [chemical binding]; other site 478801000622 acyl-activating enzyme (AAE) consensus motif; other site 478801000623 CoA binding site [chemical binding]; other site 478801000624 hypothetical protein; Provisional; Region: PRK07877 478801000625 ChaB; Region: ChaB; pfam06150 478801000626 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 478801000627 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 478801000628 putative dimer interface [polypeptide binding]; other site 478801000629 putative [2Fe-2S] cluster binding site [ion binding]; other site 478801000630 Cupin superfamily protein; Region: Cupin_4; pfam08007 478801000631 Cupin-like domain; Region: Cupin_8; pfam13621 478801000632 replicative DNA helicase; Region: DnaB; TIGR00665 478801000633 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 478801000634 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 478801000635 Walker A motif; other site 478801000636 ATP binding site [chemical binding]; other site 478801000637 Walker B motif; other site 478801000638 DNA binding loops [nucleotide binding] 478801000639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478801000640 S-adenosylmethionine binding site [chemical binding]; other site 478801000641 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 478801000642 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 478801000643 putative active site [active] 478801000644 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 478801000645 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 478801000646 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478801000647 active site 478801000648 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 478801000649 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 478801000650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478801000651 homodimer interface [polypeptide binding]; other site 478801000652 catalytic residue [active] 478801000653 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 478801000654 putative trimer interface [polypeptide binding]; other site 478801000655 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 478801000656 putative CoA binding site [chemical binding]; other site 478801000657 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 478801000658 trimer interface [polypeptide binding]; other site 478801000659 active site 478801000660 substrate binding site [chemical binding]; other site 478801000661 CoA binding site [chemical binding]; other site 478801000662 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 478801000663 active site 478801000664 oxyanion hole [active] 478801000665 catalytic triad [active] 478801000666 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 478801000667 catalytic residues [active] 478801000668 dimer interface [polypeptide binding]; other site 478801000669 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 478801000670 EamA-like transporter family; Region: EamA; pfam00892 478801000671 EamA-like transporter family; Region: EamA; pfam00892 478801000672 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 478801000673 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 478801000674 active site 478801000675 metal binding site [ion binding]; metal-binding site 478801000676 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 478801000677 extended (e) SDRs; Region: SDR_e; cd08946 478801000678 NAD(P) binding site [chemical binding]; other site 478801000679 substrate binding site [chemical binding]; other site 478801000680 active site 478801000681 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 478801000682 putative deacylase active site [active] 478801000683 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 478801000684 putative hydrophobic ligand binding site [chemical binding]; other site 478801000685 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478801000686 Beta-lactamase; Region: Beta-lactamase; pfam00144 478801000687 Lamin Tail Domain; Region: LTD; pfam00932 478801000688 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 478801000689 catalytic residues [active] 478801000690 dimer interface [polypeptide binding]; other site 478801000691 B3/4 domain; Region: B3_4; pfam03483 478801000692 Putative FMN-binding domain; Region: FMN_bind_2; cl17803 478801000693 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478801000694 Coenzyme A binding pocket [chemical binding]; other site 478801000695 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478801000696 Coenzyme A binding pocket [chemical binding]; other site 478801000697 putative phosphoketolase; Provisional; Region: PRK05261 478801000698 XFP N-terminal domain; Region: XFP_N; pfam09364 478801000699 XFP C-terminal domain; Region: XFP_C; pfam09363 478801000700 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 478801000701 Amidinotransferase; Region: Amidinotransf; pfam02274 478801000702 Histidine kinase; Region: HisKA_3; pfam07730 478801000703 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 478801000704 ATP binding site [chemical binding]; other site 478801000705 Mg2+ binding site [ion binding]; other site 478801000706 G-X-G motif; other site 478801000707 Transcriptional regulators [Transcription]; Region: MarR; COG1846 478801000708 MarR family; Region: MarR; pfam01047 478801000709 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 478801000710 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 478801000711 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801000712 Walker A/P-loop; other site 478801000713 ATP binding site [chemical binding]; other site 478801000714 Q-loop/lid; other site 478801000715 ABC transporter signature motif; other site 478801000716 Walker B; other site 478801000717 D-loop; other site 478801000718 H-loop/switch region; other site 478801000719 TIGR03086 family protein; Region: TIGR03086 478801000720 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 478801000721 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 478801000722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801000723 Walker A/P-loop; other site 478801000724 ATP binding site [chemical binding]; other site 478801000725 ABC transporter signature motif; other site 478801000726 Walker B; other site 478801000727 D-loop; other site 478801000728 H-loop/switch region; other site 478801000729 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 478801000730 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 478801000731 DNA-binding site [nucleotide binding]; DNA binding site 478801000732 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801000733 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 478801000734 Walker A/P-loop; other site 478801000735 ATP binding site [chemical binding]; other site 478801000736 Q-loop/lid; other site 478801000737 ABC transporter signature motif; other site 478801000738 Walker B; other site 478801000739 D-loop; other site 478801000740 H-loop/switch region; other site 478801000741 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 478801000742 substrate binding site [chemical binding]; other site 478801000743 multimerization interface [polypeptide binding]; other site 478801000744 ATP binding site [chemical binding]; other site 478801000745 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 478801000746 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 478801000747 active site 478801000748 catalytic tetrad [active] 478801000749 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 478801000750 thiamine phosphate binding site [chemical binding]; other site 478801000751 active site 478801000752 pyrophosphate binding site [ion binding]; other site 478801000753 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 478801000754 dimer interface [polypeptide binding]; other site 478801000755 substrate binding site [chemical binding]; other site 478801000756 ATP binding site [chemical binding]; other site 478801000757 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 478801000758 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 478801000759 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 478801000760 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 478801000761 phosphate binding site [ion binding]; other site 478801000762 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 478801000763 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 478801000764 DNA binding residues [nucleotide binding] 478801000765 drug binding residues [chemical binding]; other site 478801000766 dimer interface [polypeptide binding]; other site 478801000767 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 478801000768 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 478801000769 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 478801000770 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 478801000771 hexamer interface [polypeptide binding]; other site 478801000772 ligand binding site [chemical binding]; other site 478801000773 putative active site [active] 478801000774 NAD(P) binding site [chemical binding]; other site 478801000775 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 478801000776 Carbon starvation protein CstA; Region: CstA; pfam02554 478801000777 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 478801000778 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 478801000779 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 478801000780 DTAP/Switch II; other site 478801000781 Switch I; other site 478801000782 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 478801000783 putative active site [active] 478801000784 redox center [active] 478801000785 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 478801000786 putative hydrophobic ligand binding site [chemical binding]; other site 478801000787 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 478801000788 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 478801000789 homodimer interface [polypeptide binding]; other site 478801000790 NAD binding pocket [chemical binding]; other site 478801000791 ATP binding pocket [chemical binding]; other site 478801000792 Mg binding site [ion binding]; other site 478801000793 active-site loop [active] 478801000794 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 478801000795 classical (c) SDRs; Region: SDR_c; cd05233 478801000796 NAD(P) binding site [chemical binding]; other site 478801000797 active site 478801000798 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801000799 Major Facilitator Superfamily; Region: MFS_1; pfam07690 478801000800 putative substrate translocation pore; other site 478801000801 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 478801000802 active site 478801000803 DNA binding site [nucleotide binding] 478801000804 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 478801000805 putative active site [active] 478801000806 putative metal binding site [ion binding]; other site 478801000807 peroxiredoxin; Region: AhpC; TIGR03137 478801000808 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 478801000809 dimer interface [polypeptide binding]; other site 478801000810 decamer (pentamer of dimers) interface [polypeptide binding]; other site 478801000811 catalytic triad [active] 478801000812 peroxidatic and resolving cysteines [active] 478801000813 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 478801000814 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 478801000815 catalytic residue [active] 478801000816 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 478801000817 catalytic residues [active] 478801000818 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 478801000819 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478801000820 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 478801000821 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 478801000822 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 478801000823 dimerization interface [polypeptide binding]; other site 478801000824 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 478801000825 Ion channel; Region: Ion_trans_2; pfam07885 478801000826 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 478801000827 TrkA-N domain; Region: TrkA_N; pfam02254 478801000828 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478801000829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478801000830 active site 478801000831 phosphorylation site [posttranslational modification] 478801000832 intermolecular recognition site; other site 478801000833 dimerization interface [polypeptide binding]; other site 478801000834 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478801000835 DNA binding site [nucleotide binding] 478801000836 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 478801000837 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 478801000838 dimer interface [polypeptide binding]; other site 478801000839 phosphorylation site [posttranslational modification] 478801000840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478801000841 ATP binding site [chemical binding]; other site 478801000842 Mg2+ binding site [ion binding]; other site 478801000843 G-X-G motif; other site 478801000844 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 478801000845 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 478801000846 ligand binding site [chemical binding]; other site 478801000847 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 478801000848 Predicted methyltransferases [General function prediction only]; Region: COG0313 478801000849 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 478801000850 putative SAM binding site [chemical binding]; other site 478801000851 putative homodimer interface [polypeptide binding]; other site 478801000852 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 478801000853 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 478801000854 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 478801000855 active site 478801000856 nucleotide binding site [chemical binding]; other site 478801000857 HIGH motif; other site 478801000858 KMSKS motif; other site 478801000859 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 478801000860 tRNA binding surface [nucleotide binding]; other site 478801000861 anticodon binding site; other site 478801000862 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 478801000863 active site 478801000864 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 478801000865 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 478801000866 active site 478801000867 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 478801000868 NlpC/P60 family; Region: NLPC_P60; cl17555 478801000869 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 478801000870 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 478801000871 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 478801000872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478801000873 S-adenosylmethionine binding site [chemical binding]; other site 478801000874 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 478801000875 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 478801000876 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 478801000877 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801000878 Walker A/P-loop; other site 478801000879 ATP binding site [chemical binding]; other site 478801000880 ABC transporter signature motif; other site 478801000881 Walker B; other site 478801000882 D-loop; other site 478801000883 H-loop/switch region; other site 478801000884 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 478801000885 ferredoxin-NADP+ reductase; Region: PLN02852 478801000886 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 478801000887 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 478801000888 MarR family; Region: MarR_2; cl17246 478801000889 SnoaL-like domain; Region: SnoaL_2; pfam12680 478801000890 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 478801000891 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 478801000892 Substrate binding site; other site 478801000893 Mg++ binding site; other site 478801000894 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 478801000895 active site 478801000896 substrate binding site [chemical binding]; other site 478801000897 CoA binding site [chemical binding]; other site 478801000898 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 478801000899 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 478801000900 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 478801000901 active site 478801000902 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 478801000903 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 478801000904 5S rRNA interface [nucleotide binding]; other site 478801000905 CTC domain interface [polypeptide binding]; other site 478801000906 L16 interface [polypeptide binding]; other site 478801000907 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 478801000908 putative active site [active] 478801000909 catalytic residue [active] 478801000910 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 478801000911 active site 478801000912 Ap6A binding site [chemical binding]; other site 478801000913 nudix motif; other site 478801000914 metal binding site [ion binding]; metal-binding site 478801000915 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478801000916 catalytic core [active] 478801000917 polyphosphate kinase; Provisional; Region: PRK05443 478801000918 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 478801000919 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 478801000920 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 478801000921 putative domain interface [polypeptide binding]; other site 478801000922 putative active site [active] 478801000923 catalytic site [active] 478801000924 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 478801000925 putative active site [active] 478801000926 catalytic site [active] 478801000927 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 478801000928 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478801000929 Coenzyme A binding pocket [chemical binding]; other site 478801000930 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478801000931 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478801000932 DNA binding site [nucleotide binding] 478801000933 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 478801000934 heme-binding site [chemical binding]; other site 478801000935 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 478801000936 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 478801000937 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 478801000938 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 478801000939 PRC-barrel domain; Region: PRC; pfam05239 478801000940 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 478801000941 L-asparaginase II; Region: Asparaginase_II; pfam06089 478801000942 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 478801000943 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478801000944 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 478801000945 putative ADP-binding pocket [chemical binding]; other site 478801000946 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 478801000947 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 478801000948 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478801000949 catalytic core [active] 478801000950 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478801000951 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 478801000952 PhoU domain; Region: PhoU; pfam01895 478801000953 PhoU domain; Region: PhoU; pfam01895 478801000954 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 478801000955 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 478801000956 dimer interface [polypeptide binding]; other site 478801000957 phosphorylation site [posttranslational modification] 478801000958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478801000959 ATP binding site [chemical binding]; other site 478801000960 Mg2+ binding site [ion binding]; other site 478801000961 G-X-G motif; other site 478801000962 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478801000963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478801000964 active site 478801000965 phosphorylation site [posttranslational modification] 478801000966 intermolecular recognition site; other site 478801000967 dimerization interface [polypeptide binding]; other site 478801000968 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478801000969 DNA binding site [nucleotide binding] 478801000970 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 478801000971 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 478801000972 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 478801000973 active site 478801000974 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 478801000975 homotrimer interaction site [polypeptide binding]; other site 478801000976 zinc binding site [ion binding]; other site 478801000977 CDP-binding sites; other site 478801000978 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 478801000979 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 478801000980 NAD binding site [chemical binding]; other site 478801000981 catalytic Zn binding site [ion binding]; other site 478801000982 substrate binding site [chemical binding]; other site 478801000983 structural Zn binding site [ion binding]; other site 478801000984 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 478801000985 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 478801000986 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 478801000987 active site 478801000988 HIGH motif; other site 478801000989 nucleotide binding site [chemical binding]; other site 478801000990 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 478801000991 KMSKS motif; other site 478801000992 tRNA binding surface [nucleotide binding]; other site 478801000993 anticodon binding site; other site 478801000994 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 478801000995 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 478801000996 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 478801000997 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 478801000998 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 478801000999 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 478801001000 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 478801001001 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 478801001002 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 478801001003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478801001004 dimer interface [polypeptide binding]; other site 478801001005 conserved gate region; other site 478801001006 putative PBP binding loops; other site 478801001007 ABC-ATPase subunit interface; other site 478801001008 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 478801001009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478801001010 dimer interface [polypeptide binding]; other site 478801001011 conserved gate region; other site 478801001012 putative PBP binding loops; other site 478801001013 ABC-ATPase subunit interface; other site 478801001014 Transcriptional regulators [Transcription]; Region: PurR; COG1609 478801001015 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 478801001016 DNA binding site [nucleotide binding] 478801001017 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 478801001018 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 478801001019 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 478801001020 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 478801001021 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 478801001022 active site 478801001023 homotetramer interface [polypeptide binding]; other site 478801001024 Protein kinase domain; Region: Pkinase; pfam00069 478801001025 Catalytic domain of Protein Kinases; Region: PKc; cd00180 478801001026 active site 478801001027 ATP binding site [chemical binding]; other site 478801001028 substrate binding site [chemical binding]; other site 478801001029 activation loop (A-loop); other site 478801001030 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 478801001031 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 478801001032 Bacterial SH3 domain; Region: SH3_3; cl17532 478801001033 Bacterial SH3 domain; Region: SH3_3; pfam08239 478801001034 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 478801001035 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 478801001036 NADH(P)-binding; Region: NAD_binding_10; pfam13460 478801001037 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 478801001038 NAD(P) binding site [chemical binding]; other site 478801001039 putative active site [active] 478801001040 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 478801001041 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 478801001042 catalytic residues [active] 478801001043 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 478801001044 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 478801001045 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 478801001046 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478801001047 putative DNA binding site [nucleotide binding]; other site 478801001048 putative Zn2+ binding site [ion binding]; other site 478801001049 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 478801001050 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 478801001051 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 478801001052 Walker A/P-loop; other site 478801001053 ATP binding site [chemical binding]; other site 478801001054 Q-loop/lid; other site 478801001055 ABC transporter signature motif; other site 478801001056 Walker B; other site 478801001057 D-loop; other site 478801001058 H-loop/switch region; other site 478801001059 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 478801001060 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 478801001061 Walker A/P-loop; other site 478801001062 ATP binding site [chemical binding]; other site 478801001063 Q-loop/lid; other site 478801001064 ABC transporter signature motif; other site 478801001065 Walker B; other site 478801001066 D-loop; other site 478801001067 H-loop/switch region; other site 478801001068 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 478801001069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 478801001070 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 478801001071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478801001072 dimer interface [polypeptide binding]; other site 478801001073 conserved gate region; other site 478801001074 putative PBP binding loops; other site 478801001075 ABC-ATPase subunit interface; other site 478801001076 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 478801001077 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 478801001078 BCCT family transporter; Region: BCCT; pfam02028 478801001079 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 478801001080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478801001081 active site 478801001082 phosphorylation site [posttranslational modification] 478801001083 intermolecular recognition site; other site 478801001084 dimerization interface [polypeptide binding]; other site 478801001085 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 478801001086 DNA binding residues [nucleotide binding] 478801001087 dimerization interface [polypeptide binding]; other site 478801001088 Histidine kinase; Region: HisKA_3; pfam07730 478801001089 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 478801001090 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 478801001091 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 478801001092 Walker A/P-loop; other site 478801001093 ATP binding site [chemical binding]; other site 478801001094 Q-loop/lid; other site 478801001095 ABC transporter signature motif; other site 478801001096 Walker B; other site 478801001097 D-loop; other site 478801001098 H-loop/switch region; other site 478801001099 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 478801001100 Cysteine-rich domain; Region: CCG; pfam02754 478801001101 Cysteine-rich domain; Region: CCG; pfam02754 478801001102 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 478801001103 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 478801001104 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 478801001105 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 478801001106 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 478801001107 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 478801001108 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 478801001109 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 478801001110 NAD(P) binding site [chemical binding]; other site 478801001111 Protein of unknown function (DUF461); Region: DUF461; pfam04314 478801001112 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 478801001113 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 478801001114 Transcriptional regulator [Transcription]; Region: IclR; COG1414 478801001115 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 478801001116 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 478801001117 Na binding site [ion binding]; other site 478801001118 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 478801001119 active sites [active] 478801001120 tetramer interface [polypeptide binding]; other site 478801001121 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 478801001122 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 478801001123 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 478801001124 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 478801001125 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 478801001126 molybdopterin cofactor binding site; other site 478801001127 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 478801001128 4Fe-4S binding domain; Region: Fer4; pfam00037 478801001129 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 478801001130 selenium donor protein; Region: selD; TIGR00476 478801001131 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 478801001132 dimerization interface [polypeptide binding]; other site 478801001133 putative ATP binding site [chemical binding]; other site 478801001134 selenocysteine synthase; Provisional; Region: PRK04311 478801001135 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 478801001136 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 478801001137 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 478801001138 G1 box; other site 478801001139 GTP/Mg2+ binding site [chemical binding]; other site 478801001140 G2 box; other site 478801001141 Switch I region; other site 478801001142 G3 box; other site 478801001143 Switch II region; other site 478801001144 G4 box; other site 478801001145 G5 box; other site 478801001146 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 478801001147 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 478801001148 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 478801001149 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 478801001150 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478801001151 catalytic residue [active] 478801001152 urocanate hydratase; Provisional; Region: PRK05414 478801001153 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 478801001154 FAD binding domain; Region: FAD_binding_4; pfam01565 478801001155 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 478801001156 Cysteine-rich domain; Region: CCG; pfam02754 478801001157 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 478801001158 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 478801001159 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 478801001160 hydroxyglutarate oxidase; Provisional; Region: PRK11728 478801001161 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 478801001162 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 478801001163 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 478801001164 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 478801001165 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 478801001166 NAD(P) binding site [chemical binding]; other site 478801001167 aldehyde dehydrogenase family 7 member; Region: PLN02315 478801001168 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 478801001169 tetrameric interface [polypeptide binding]; other site 478801001170 NAD binding site [chemical binding]; other site 478801001171 catalytic residues [active] 478801001172 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 478801001173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 478801001174 Transcriptional regulator [Transcription]; Region: LysR; COG0583 478801001175 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 478801001176 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 478801001177 dimerization interface [polypeptide binding]; other site 478801001178 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 478801001179 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 478801001180 NAD(P) binding pocket [chemical binding]; other site 478801001181 Uncharacterized conserved protein [Function unknown]; Region: COG3342 478801001182 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 478801001183 Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823 478801001184 imidazolonepropionase; Provisional; Region: PRK14085 478801001185 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 478801001186 active site 478801001187 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 478801001188 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 478801001189 metal binding site [ion binding]; metal-binding site 478801001190 dimer interface [polypeptide binding]; other site 478801001191 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 478801001192 Bacterial SH3 domain; Region: SH3_3; pfam08239 478801001193 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 478801001194 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 478801001195 NlpC/P60 family; Region: NLPC_P60; cl17555 478801001196 Histidine kinase; Region: HisKA_3; pfam07730 478801001197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478801001198 ATP binding site [chemical binding]; other site 478801001199 Mg2+ binding site [ion binding]; other site 478801001200 G-X-G motif; other site 478801001201 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 478801001202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478801001203 active site 478801001204 phosphorylation site [posttranslational modification] 478801001205 intermolecular recognition site; other site 478801001206 dimerization interface [polypeptide binding]; other site 478801001207 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 478801001208 DNA binding residues [nucleotide binding] 478801001209 dimerization interface [polypeptide binding]; other site 478801001210 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 478801001211 E3 interaction surface; other site 478801001212 lipoyl attachment site [posttranslational modification]; other site 478801001213 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 478801001214 e3 binding domain; Region: E3_binding; pfam02817 478801001215 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 478801001216 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 478801001217 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 478801001218 alpha subunit interface [polypeptide binding]; other site 478801001219 TPP binding site [chemical binding]; other site 478801001220 heterodimer interface [polypeptide binding]; other site 478801001221 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 478801001222 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 478801001223 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 478801001224 tetramer interface [polypeptide binding]; other site 478801001225 TPP-binding site [chemical binding]; other site 478801001226 heterodimer interface [polypeptide binding]; other site 478801001227 phosphorylation loop region [posttranslational modification] 478801001228 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 478801001229 putative hydrolase; Provisional; Region: PRK11460 478801001230 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 478801001231 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 478801001232 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 478801001233 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 478801001234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478801001235 ABC-ATPase subunit interface; other site 478801001236 putative PBP binding loops; other site 478801001237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 478801001238 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 478801001239 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 478801001240 Walker A/P-loop; other site 478801001241 ATP binding site [chemical binding]; other site 478801001242 Q-loop/lid; other site 478801001243 ABC transporter signature motif; other site 478801001244 Walker B; other site 478801001245 D-loop; other site 478801001246 H-loop/switch region; other site 478801001247 GAF domain; Region: GAF; cl17456 478801001248 ANTAR domain; Region: ANTAR; pfam03861 478801001249 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 478801001250 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 478801001251 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478801001252 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cd07307 478801001253 MMPL family; Region: MMPL; pfam03176 478801001254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801001255 Major Facilitator Superfamily; Region: MFS_1; pfam07690 478801001256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801001257 putative substrate translocation pore; other site 478801001258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801001259 Major Facilitator Superfamily; Region: MFS_1; pfam07690 478801001260 CAAX protease self-immunity; Region: Abi; pfam02517 478801001261 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 478801001262 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 478801001263 FAD binding pocket [chemical binding]; other site 478801001264 FAD binding motif [chemical binding]; other site 478801001265 phosphate binding motif [ion binding]; other site 478801001266 NAD binding pocket [chemical binding]; other site 478801001267 Uncharacterized conserved protein [Function unknown]; Region: COG1432 478801001268 LabA_like proteins; Region: LabA_like; cd06167 478801001269 putative metal binding site [ion binding]; other site 478801001270 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cl14879 478801001271 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 478801001272 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 478801001273 CoenzymeA binding site [chemical binding]; other site 478801001274 subunit interaction site [polypeptide binding]; other site 478801001275 PHB binding site; other site 478801001276 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 478801001277 substrate binding site [chemical binding]; other site 478801001278 TIGR03086 family protein; Region: TIGR03086 478801001279 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 478801001280 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 478801001281 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 478801001282 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 478801001283 catalytic residue [active] 478801001284 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 478801001285 substrate-cofactor binding pocket; other site 478801001286 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 478801001287 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 478801001288 homodimer interface [polypeptide binding]; other site 478801001289 substrate-cofactor binding pocket; other site 478801001290 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478801001291 catalytic residue [active] 478801001292 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 478801001293 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 478801001294 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 478801001295 substrate binding site [chemical binding]; other site 478801001296 THF binding site; other site 478801001297 zinc-binding site [ion binding]; other site 478801001298 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 478801001299 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 478801001300 Helix-turn-helix domain; Region: HTH_17; pfam12728 478801001301 EamA-like transporter family; Region: EamA; pfam00892 478801001302 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 478801001303 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 478801001304 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 478801001305 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478801001306 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 478801001307 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 478801001308 Multicopper oxidase; Region: Cu-oxidase; pfam00394 478801001309 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 478801001310 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478801001311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478801001312 active site 478801001313 phosphorylation site [posttranslational modification] 478801001314 intermolecular recognition site; other site 478801001315 dimerization interface [polypeptide binding]; other site 478801001316 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478801001317 DNA binding site [nucleotide binding] 478801001318 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 478801001319 dimerization interface [polypeptide binding]; other site 478801001320 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 478801001321 dimer interface [polypeptide binding]; other site 478801001322 phosphorylation site [posttranslational modification] 478801001323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478801001324 ATP binding site [chemical binding]; other site 478801001325 Mg2+ binding site [ion binding]; other site 478801001326 G-X-G motif; other site 478801001327 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 478801001328 metal-binding site [ion binding] 478801001329 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 478801001330 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478801001331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478801001332 motif I; other site 478801001333 motif II; other site 478801001334 Domain of unknown function (DUF305); Region: DUF305; pfam03713 478801001335 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 478801001336 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 478801001337 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 478801001338 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 478801001339 N-acetyl-D-glucosamine binding site [chemical binding]; other site 478801001340 catalytic residue [active] 478801001341 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801001342 Walker A/P-loop; other site 478801001343 ATP binding site [chemical binding]; other site 478801001344 Q-loop/lid; other site 478801001345 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801001346 ABC transporter signature motif; other site 478801001347 Walker B; other site 478801001348 D-loop; other site 478801001349 H-loop/switch region; other site 478801001350 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801001351 Q-loop/lid; other site 478801001352 ABC transporter signature motif; other site 478801001353 Walker B; other site 478801001354 D-loop; other site 478801001355 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 478801001356 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 478801001357 Sulfate transporter family; Region: Sulfate_transp; pfam00916 478801001358 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 478801001359 H+ Antiporter protein; Region: 2A0121; TIGR00900 478801001360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 478801001361 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 478801001362 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 478801001363 Protein of unknown function, DUF393; Region: DUF393; cl01136 478801001364 Domain of unknown function (DUF389); Region: DUF389; cl00781 478801001365 LysE type translocator; Region: LysE; cl00565 478801001366 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 478801001367 iron-sulfur cluster [ion binding]; other site 478801001368 [2Fe-2S] cluster binding site [ion binding]; other site 478801001369 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 478801001370 aromatic arch; other site 478801001371 DCoH dimer interaction site [polypeptide binding]; other site 478801001372 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 478801001373 DCoH tetramer interaction site [polypeptide binding]; other site 478801001374 substrate binding site [chemical binding]; other site 478801001375 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 478801001376 hydrophobic ligand binding site; other site 478801001377 glutathione synthetase; Provisional; Region: PRK12458 478801001378 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 478801001379 ATP-grasp domain; Region: ATP-grasp_4; cl17255 478801001380 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 478801001381 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 478801001382 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 478801001383 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 478801001384 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 478801001385 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 478801001386 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 478801001387 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 478801001388 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 478801001389 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 478801001390 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 478801001391 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 478801001392 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 478801001393 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 478801001394 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 478801001395 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801001396 Walker A/P-loop; other site 478801001397 ATP binding site [chemical binding]; other site 478801001398 Q-loop/lid; other site 478801001399 ABC transporter signature motif; other site 478801001400 Walker B; other site 478801001401 D-loop; other site 478801001402 H-loop/switch region; other site 478801001403 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 478801001404 classical (c) SDRs; Region: SDR_c; cd05233 478801001405 NAD(P) binding site [chemical binding]; other site 478801001406 active site 478801001407 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 478801001408 putative active site [active] 478801001409 catalytic site [active] 478801001410 RibD C-terminal domain; Region: RibD_C; cl17279 478801001411 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 478801001412 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478801001413 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478801001414 dimerization interface [polypeptide binding]; other site 478801001415 putative DNA binding site [nucleotide binding]; other site 478801001416 putative Zn2+ binding site [ion binding]; other site 478801001417 cyclase homology domain; Region: CHD; cd07302 478801001418 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 478801001419 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478801001420 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478801001421 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 478801001422 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 478801001423 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 478801001424 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 478801001425 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 478801001426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478801001427 short chain dehydrogenase; Provisional; Region: PRK06197 478801001428 NAD(P) binding site [chemical binding]; other site 478801001429 active site 478801001430 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478801001431 NAD(P) binding site [chemical binding]; other site 478801001432 protochlorophyllide reductase; Region: PLN00015 478801001433 active site 478801001434 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478801001435 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478801001436 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478801001437 MULE transposase domain; Region: MULE; pfam10551 478801001438 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 478801001439 SnoaL-like domain; Region: SnoaL_3; pfam13474 478801001440 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 478801001441 SnoaL-like domain; Region: SnoaL_3; pfam13474 478801001442 RNA polymerase factor sigma-70; Validated; Region: PRK08241 478801001443 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478801001444 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 478801001445 DNA binding residues [nucleotide binding] 478801001446 SnoaL-like domain; Region: SnoaL_2; pfam12680 478801001447 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478801001448 Beta-lactamase; Region: Beta-lactamase; pfam00144 478801001449 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 478801001450 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 478801001451 nucleotide binding site [chemical binding]; other site 478801001452 GrpE; Region: GrpE; pfam01025 478801001453 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 478801001454 dimer interface [polypeptide binding]; other site 478801001455 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 478801001456 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 478801001457 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 478801001458 HSP70 interaction site [polypeptide binding]; other site 478801001459 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 478801001460 dimer interface [polypeptide binding]; other site 478801001461 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 478801001462 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 478801001463 DNA binding residues [nucleotide binding] 478801001464 putative dimer interface [polypeptide binding]; other site 478801001465 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 478801001466 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 478801001467 active site 478801001468 catalytic triad [active] 478801001469 PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120 478801001470 PA/protease or protease-like domain interface [polypeptide binding]; other site 478801001471 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 478801001472 catalytic residues [active] 478801001473 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 478801001474 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 478801001475 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 478801001476 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 478801001477 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 478801001478 active site 478801001479 catalytic triad [active] 478801001480 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 478801001481 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 478801001482 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 478801001483 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 478801001484 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 478801001485 Clp amino terminal domain; Region: Clp_N; pfam02861 478801001486 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478801001487 Walker A motif; other site 478801001488 ATP binding site [chemical binding]; other site 478801001489 Walker B motif; other site 478801001490 arginine finger; other site 478801001491 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478801001492 Walker A motif; other site 478801001493 ATP binding site [chemical binding]; other site 478801001494 Walker B motif; other site 478801001495 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 478801001496 oxidoreductase; Provisional; Region: PRK06128 478801001497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478801001498 NAD(P) binding site [chemical binding]; other site 478801001499 active site 478801001500 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 478801001501 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 478801001502 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 478801001503 putative catalytic site [active] 478801001504 putative phosphate binding site [ion binding]; other site 478801001505 active site 478801001506 metal binding site A [ion binding]; metal-binding site 478801001507 DNA binding site [nucleotide binding] 478801001508 putative AP binding site [nucleotide binding]; other site 478801001509 putative metal binding site B [ion binding]; other site 478801001510 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 478801001511 H+ Antiporter protein; Region: 2A0121; TIGR00900 478801001512 short chain dehydrogenase; Provisional; Region: PRK08219 478801001513 classical (c) SDRs; Region: SDR_c; cd05233 478801001514 NAD(P) binding site [chemical binding]; other site 478801001515 active site 478801001516 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 478801001517 active site 478801001518 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 478801001519 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 478801001520 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 478801001521 active site 478801001522 intersubunit interface [polypeptide binding]; other site 478801001523 zinc binding site [ion binding]; other site 478801001524 Na+ binding site [ion binding]; other site 478801001525 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 478801001526 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 478801001527 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 478801001528 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 478801001529 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 478801001530 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 478801001531 DNA-binding site [nucleotide binding]; DNA binding site 478801001532 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 478801001533 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 478801001534 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 478801001535 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 478801001536 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 478801001537 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 478801001538 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 478801001539 GDP-binding site [chemical binding]; other site 478801001540 ACT binding site; other site 478801001541 IMP binding site; other site 478801001542 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 478801001543 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 478801001544 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 478801001545 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 478801001546 NAD-dependent deacetylase; Provisional; Region: PRK00481 478801001547 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 478801001548 NAD+ binding site [chemical binding]; other site 478801001549 substrate binding site [chemical binding]; other site 478801001550 Zn binding site [ion binding]; other site 478801001551 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478801001552 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478801001553 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 478801001554 putative ADP-ribose binding site [chemical binding]; other site 478801001555 putative active site [active] 478801001556 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 478801001557 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 478801001558 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 478801001559 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 478801001560 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 478801001561 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 478801001562 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 478801001563 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 478801001564 ATP binding site [chemical binding]; other site 478801001565 active site 478801001566 substrate binding site [chemical binding]; other site 478801001567 Fic/DOC family; Region: Fic; cl00960 478801001568 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 478801001569 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 478801001570 active site 478801001571 active site 478801001572 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 478801001573 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 478801001574 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 478801001575 putative active site [active] 478801001576 catalytic triad [active] 478801001577 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 478801001578 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 478801001579 dimerization interface [polypeptide binding]; other site 478801001580 ATP binding site [chemical binding]; other site 478801001581 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 478801001582 dimerization interface [polypeptide binding]; other site 478801001583 ATP binding site [chemical binding]; other site 478801001584 aminotransferase AlaT; Validated; Region: PRK09265 478801001585 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 478801001586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478801001587 homodimer interface [polypeptide binding]; other site 478801001588 catalytic residue [active] 478801001589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 478801001590 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 478801001591 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 478801001592 catalytic Zn binding site [ion binding]; other site 478801001593 NAD(P) binding site [chemical binding]; other site 478801001594 structural Zn binding site [ion binding]; other site 478801001595 Amidinotransferase; Region: Amidinotransf; cl12043 478801001596 amidophosphoribosyltransferase; Provisional; Region: PRK07847 478801001597 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 478801001598 active site 478801001599 tetramer interface [polypeptide binding]; other site 478801001600 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 478801001601 active site 478801001602 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 478801001603 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 478801001604 dimerization interface [polypeptide binding]; other site 478801001605 putative ATP binding site [chemical binding]; other site 478801001606 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 478801001607 CopC domain; Region: CopC; pfam04234 478801001608 Uncharacterized conserved protein [Function unknown]; Region: COG1739 478801001609 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 478801001610 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 478801001611 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 478801001612 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 478801001613 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 478801001614 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478801001615 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 478801001616 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 478801001617 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 478801001618 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 478801001619 Glutamine amidotransferase class-I; Region: GATase; pfam00117 478801001620 glutamine binding [chemical binding]; other site 478801001621 catalytic triad [active] 478801001622 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 478801001623 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 478801001624 hypothetical protein; Provisional; Region: PRK07945 478801001625 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 478801001626 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 478801001627 active site 478801001628 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478801001629 Coenzyme A binding pocket [chemical binding]; other site 478801001630 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 478801001631 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 478801001632 Histidine kinase; Region: HisKA_3; pfam07730 478801001633 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478801001634 Mg2+ binding site [ion binding]; other site 478801001635 G-X-G motif; other site 478801001636 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 478801001637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478801001638 active site 478801001639 phosphorylation site [posttranslational modification] 478801001640 intermolecular recognition site; other site 478801001641 dimerization interface [polypeptide binding]; other site 478801001642 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 478801001643 DNA binding residues [nucleotide binding] 478801001644 dimerization interface [polypeptide binding]; other site 478801001645 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 478801001646 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 478801001647 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801001648 ABC transporter signature motif; other site 478801001649 Walker B; other site 478801001650 D-loop; other site 478801001651 H-loop/switch region; other site 478801001652 Prokaryotic E2 family A; Region: Prok-E2_A; pfam14457 478801001653 ThiF family; Region: ThiF; pfam00899 478801001654 ATP binding site [chemical binding]; other site 478801001655 substrate interface [chemical binding]; other site 478801001656 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 478801001657 active site 478801001658 NTP binding site [chemical binding]; other site 478801001659 metal binding triad [ion binding]; metal-binding site 478801001660 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 478801001661 nucleophile elbow; other site 478801001662 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 478801001663 putative dimer interface [polypeptide binding]; other site 478801001664 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478801001665 ligand binding site [chemical binding]; other site 478801001666 Zn binding site [ion binding]; other site 478801001667 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478801001668 MULE transposase domain; Region: MULE; pfam10551 478801001669 Domain of unknown function (DUF955); Region: DUF955; cl01076 478801001670 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 478801001671 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478801001672 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 478801001673 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478801001674 TrwC relaxase; Region: TrwC; pfam08751 478801001675 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 478801001676 AAA domain; Region: AAA_30; pfam13604 478801001677 AAA domain; Region: AAA_22; pfam13401 478801001678 Family description; Region: UvrD_C_2; pfam13538 478801001679 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478801001680 C factor cell-cell signaling protein; Provisional; Region: PRK09009 478801001681 NAD(P) binding site [chemical binding]; other site 478801001682 active site 478801001683 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 478801001684 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478801001685 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478801001686 DNA binding residues [nucleotide binding] 478801001687 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 478801001688 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 478801001689 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 478801001690 DNA binding site [nucleotide binding] 478801001691 active site 478801001692 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; cl17606 478801001693 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 478801001694 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 478801001695 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 478801001696 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 478801001697 AlkA N-terminal domain; Region: AlkA_N; cl05528 478801001698 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 478801001699 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 478801001700 minor groove reading motif; other site 478801001701 helix-hairpin-helix signature motif; other site 478801001702 substrate binding pocket [chemical binding]; other site 478801001703 active site 478801001704 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 478801001705 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 478801001706 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 478801001707 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478801001708 MULE transposase domain; Region: MULE; pfam10551 478801001709 Domain of unknown function (DUF955); Region: DUF955; pfam06114 478801001710 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 478801001711 polymerase nucleotide-binding site; other site 478801001712 DNA-binding residues [nucleotide binding]; DNA binding site 478801001713 nucleotide binding site [chemical binding]; other site 478801001714 primase nucleotide-binding site [nucleotide binding]; other site 478801001715 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 478801001716 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 478801001717 ParB-like nuclease domain; Region: ParB; smart00470 478801001718 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 478801001719 Peptidase family M23; Region: Peptidase_M23; pfam01551 478801001720 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 478801001721 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 478801001722 active site 478801001723 catalytic residues [active] 478801001724 DNA binding site [nucleotide binding] 478801001725 Int/Topo IB signature motif; other site 478801001726 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 478801001727 non-specific DNA binding site [nucleotide binding]; other site 478801001728 salt bridge; other site 478801001729 sequence-specific DNA binding site [nucleotide binding]; other site 478801001730 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 478801001731 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478801001732 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 478801001733 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 478801001734 Walker A/P-loop; other site 478801001735 ATP binding site [chemical binding]; other site 478801001736 Q-loop/lid; other site 478801001737 ABC transporter signature motif; other site 478801001738 Walker B; other site 478801001739 D-loop; other site 478801001740 H-loop/switch region; other site 478801001741 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 478801001742 AAA-like domain; Region: AAA_10; pfam12846 478801001743 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 478801001744 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 478801001745 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 478801001746 dimer interface [polypeptide binding]; other site 478801001747 ssDNA binding site [nucleotide binding]; other site 478801001748 tetramer (dimer of dimers) interface [polypeptide binding]; other site 478801001749 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 478801001750 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478801001751 ATP binding site [chemical binding]; other site 478801001752 putative Mg++ binding site [ion binding]; other site 478801001753 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478801001754 nucleotide binding region [chemical binding]; other site 478801001755 ATP-binding site [chemical binding]; other site 478801001756 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 478801001757 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 478801001758 Walker A/P-loop; other site 478801001759 ATP binding site [chemical binding]; other site 478801001760 Q-loop/lid; other site 478801001761 ABC transporter signature motif; other site 478801001762 Walker B; other site 478801001763 D-loop; other site 478801001764 H-loop/switch region; other site 478801001765 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 478801001766 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801001767 Walker A/P-loop; other site 478801001768 ATP binding site [chemical binding]; other site 478801001769 Q-loop/lid; other site 478801001770 ABC transporter signature motif; other site 478801001771 Walker B; other site 478801001772 D-loop; other site 478801001773 H-loop/switch region; other site 478801001774 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 478801001775 Isochorismatase family; Region: Isochorismatase; pfam00857 478801001776 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 478801001777 catalytic triad [active] 478801001778 conserved cis-peptide bond; other site 478801001779 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478801001780 ATP binding site [chemical binding]; other site 478801001781 putative Mg++ binding site [ion binding]; other site 478801001782 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478801001783 nucleotide binding region [chemical binding]; other site 478801001784 ATP-binding site [chemical binding]; other site 478801001785 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 478801001786 PBP superfamily domain; Region: PBP_like_2; cl17296 478801001787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478801001788 dimer interface [polypeptide binding]; other site 478801001789 conserved gate region; other site 478801001790 putative PBP binding loops; other site 478801001791 ABC-ATPase subunit interface; other site 478801001792 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 478801001793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478801001794 dimer interface [polypeptide binding]; other site 478801001795 conserved gate region; other site 478801001796 putative PBP binding loops; other site 478801001797 ABC-ATPase subunit interface; other site 478801001798 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 478801001799 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 478801001800 Walker A/P-loop; other site 478801001801 ATP binding site [chemical binding]; other site 478801001802 Q-loop/lid; other site 478801001803 ABC transporter signature motif; other site 478801001804 Walker B; other site 478801001805 D-loop; other site 478801001806 H-loop/switch region; other site 478801001807 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 478801001808 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478801001809 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 478801001810 Repair protein; Region: Repair_PSII; pfam04536 478801001811 EspG family; Region: ESX-1_EspG; pfam14011 478801001812 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 478801001813 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 478801001814 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478801001815 ATP binding site [chemical binding]; other site 478801001816 putative Mg++ binding site [ion binding]; other site 478801001817 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478801001818 nucleotide binding region [chemical binding]; other site 478801001819 ATP-binding site [chemical binding]; other site 478801001820 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 478801001821 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 478801001822 homodimer interface [polypeptide binding]; other site 478801001823 metal binding site [ion binding]; metal-binding site 478801001824 enolase; Provisional; Region: eno; PRK00077 478801001825 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 478801001826 dimer interface [polypeptide binding]; other site 478801001827 metal binding site [ion binding]; metal-binding site 478801001828 substrate binding pocket [chemical binding]; other site 478801001829 Septum formation initiator; Region: DivIC; pfam04977 478801001830 Protein of unknown function (DUF501); Region: DUF501; pfam04417 478801001831 exopolyphosphatase; Region: exo_poly_only; TIGR03706 478801001832 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 478801001833 Bax inhibitor 1 like; Region: BaxI_1; cl17691 478801001834 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 478801001835 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 478801001836 putative active site [active] 478801001837 putative metal binding site [ion binding]; other site 478801001838 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 478801001839 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 478801001840 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 478801001841 dimer interface [polypeptide binding]; other site 478801001842 active site 478801001843 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 478801001844 active site 478801001845 catalytic triad [active] 478801001846 oxyanion hole [active] 478801001847 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 478801001848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478801001849 NAD(P) binding site [chemical binding]; other site 478801001850 active site 478801001851 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 478801001852 peptide synthase; Provisional; Region: PRK09274 478801001853 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478801001854 acyl-activating enzyme (AAE) consensus motif; other site 478801001855 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478801001856 AMP binding site [chemical binding]; other site 478801001857 active site 478801001858 acyl-activating enzyme (AAE) consensus motif; other site 478801001859 CoA binding site [chemical binding]; other site 478801001860 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 478801001861 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 478801001862 active site 478801001863 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 478801001864 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 478801001865 Walker A/P-loop; other site 478801001866 ATP binding site [chemical binding]; other site 478801001867 Q-loop/lid; other site 478801001868 ABC transporter signature motif; other site 478801001869 Walker B; other site 478801001870 D-loop; other site 478801001871 H-loop/switch region; other site 478801001872 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 478801001873 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 478801001874 Walker A/P-loop; other site 478801001875 ATP binding site [chemical binding]; other site 478801001876 Q-loop/lid; other site 478801001877 ABC transporter signature motif; other site 478801001878 Walker B; other site 478801001879 D-loop; other site 478801001880 H-loop/switch region; other site 478801001881 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 478801001882 Histidine kinase; Region: HisKA_3; pfam07730 478801001883 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 478801001884 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 478801001885 DNA binding residues [nucleotide binding] 478801001886 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 478801001887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801001888 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 478801001889 Walker A/P-loop; other site 478801001890 ATP binding site [chemical binding]; other site 478801001891 Q-loop/lid; other site 478801001892 ABC transporter signature motif; other site 478801001893 Walker B; other site 478801001894 D-loop; other site 478801001895 H-loop/switch region; other site 478801001896 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 478801001897 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 478801001898 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 478801001899 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 478801001900 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 478801001901 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 478801001902 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 478801001903 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 478801001904 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 478801001905 catalytic residue [active] 478801001906 putative FPP diphosphate binding site; other site 478801001907 putative FPP binding hydrophobic cleft; other site 478801001908 dimer interface [polypeptide binding]; other site 478801001909 putative IPP diphosphate binding site; other site 478801001910 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 478801001911 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 478801001912 putative active site [active] 478801001913 PhoH-like protein; Region: PhoH; pfam02562 478801001914 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 478801001915 N-acetyl-D-glucosamine binding site [chemical binding]; other site 478801001916 catalytic residue [active] 478801001917 fumarate hydratase; Reviewed; Region: fumC; PRK00485 478801001918 Class II fumarases; Region: Fumarase_classII; cd01362 478801001919 active site 478801001920 tetramer interface [polypeptide binding]; other site 478801001921 pantothenate kinase; Provisional; Region: PRK05439 478801001922 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 478801001923 ATP-binding site [chemical binding]; other site 478801001924 CoA-binding site [chemical binding]; other site 478801001925 Mg2+-binding site [ion binding]; other site 478801001926 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 478801001927 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 478801001928 glutaminase active site [active] 478801001929 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 478801001930 dimer interface [polypeptide binding]; other site 478801001931 active site 478801001932 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 478801001933 dimer interface [polypeptide binding]; other site 478801001934 active site 478801001935 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 478801001936 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 478801001937 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 478801001938 putative substrate binding site [chemical binding]; other site 478801001939 putative ATP binding site [chemical binding]; other site 478801001940 hypothetical protein; Provisional; Region: PHA03169 478801001941 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 478801001942 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478801001943 active site 478801001944 motif I; other site 478801001945 motif II; other site 478801001946 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478801001947 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 478801001948 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 478801001949 alanine racemase; Reviewed; Region: alr; PRK00053 478801001950 active site 478801001951 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 478801001952 dimer interface [polypeptide binding]; other site 478801001953 substrate binding site [chemical binding]; other site 478801001954 catalytic residues [active] 478801001955 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478801001956 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 478801001957 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 478801001958 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 478801001959 Glycoprotease family; Region: Peptidase_M22; pfam00814 478801001960 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 478801001961 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478801001962 Coenzyme A binding pocket [chemical binding]; other site 478801001963 UGMP family protein; Validated; Region: PRK09604 478801001964 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 478801001965 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 478801001966 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 478801001967 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 478801001968 PLD-like domain; Region: PLDc_2; pfam13091 478801001969 putative active site [active] 478801001970 catalytic site [active] 478801001971 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 478801001972 PLD-like domain; Region: PLDc_2; pfam13091 478801001973 putative active site [active] 478801001974 catalytic site [active] 478801001975 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 478801001976 oligomerisation interface [polypeptide binding]; other site 478801001977 mobile loop; other site 478801001978 roof hairpin; other site 478801001979 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 478801001980 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 478801001981 ring oligomerisation interface [polypeptide binding]; other site 478801001982 ATP/Mg binding site [chemical binding]; other site 478801001983 stacking interactions; other site 478801001984 hinge regions; other site 478801001985 S4 domain; Region: S4_2; pfam13275 478801001986 Transcription factor WhiB; Region: Whib; pfam02467 478801001987 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 478801001988 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 478801001989 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 478801001990 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 478801001991 active site 478801001992 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 478801001993 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 478801001994 active site 478801001995 Predicted membrane protein [Function unknown]; Region: COG4270 478801001996 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 478801001997 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 478801001998 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801001999 Walker A/P-loop; other site 478801002000 ATP binding site [chemical binding]; other site 478801002001 Q-loop/lid; other site 478801002002 ABC transporter signature motif; other site 478801002003 Walker B; other site 478801002004 D-loop; other site 478801002005 H-loop/switch region; other site 478801002006 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 478801002007 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 478801002008 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801002009 Walker A/P-loop; other site 478801002010 ATP binding site [chemical binding]; other site 478801002011 Q-loop/lid; other site 478801002012 ABC transporter signature motif; other site 478801002013 Walker B; other site 478801002014 D-loop; other site 478801002015 H-loop/switch region; other site 478801002016 Uncharacterized conserved protein [Function unknown]; Region: COG3391 478801002017 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 478801002018 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 478801002019 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cl01321 478801002020 integral membrane protein; Region: integ_memb_HG; TIGR03954 478801002021 GMP synthase; Reviewed; Region: guaA; PRK00074 478801002022 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 478801002023 AMP/PPi binding site [chemical binding]; other site 478801002024 candidate oxyanion hole; other site 478801002025 catalytic triad [active] 478801002026 potential glutamine specificity residues [chemical binding]; other site 478801002027 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 478801002028 ATP Binding subdomain [chemical binding]; other site 478801002029 Ligand Binding sites [chemical binding]; other site 478801002030 Dimerization subdomain; other site 478801002031 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 478801002032 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 478801002033 nudix motif; other site 478801002034 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 478801002035 Part of AAA domain; Region: AAA_19; pfam13245 478801002036 Family description; Region: UvrD_C_2; pfam13538 478801002037 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 478801002038 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 478801002039 CoA-ligase; Region: Ligase_CoA; pfam00549 478801002040 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 478801002041 CoA binding domain; Region: CoA_binding; smart00881 478801002042 CoA-ligase; Region: Ligase_CoA; pfam00549 478801002043 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 478801002044 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 478801002045 NAD(P) binding site [chemical binding]; other site 478801002046 PRC-barrel domain; Region: PRC; pfam05239 478801002047 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 478801002048 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 478801002049 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 478801002050 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 478801002051 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 478801002052 active site 478801002053 substrate binding site [chemical binding]; other site 478801002054 cosubstrate binding site; other site 478801002055 catalytic site [active] 478801002056 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 478801002057 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 478801002058 purine monophosphate binding site [chemical binding]; other site 478801002059 dimer interface [polypeptide binding]; other site 478801002060 putative catalytic residues [active] 478801002061 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 478801002062 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 478801002063 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 478801002064 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 478801002065 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 478801002066 homodimer interface [polypeptide binding]; other site 478801002067 NADP binding site [chemical binding]; other site 478801002068 substrate binding site [chemical binding]; other site 478801002069 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 478801002070 malate dehydrogenase; Provisional; Region: PRK05442 478801002071 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 478801002072 NAD(P) binding site [chemical binding]; other site 478801002073 dimer interface [polypeptide binding]; other site 478801002074 malate binding site [chemical binding]; other site 478801002075 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 478801002076 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 478801002077 active site 478801002078 HIGH motif; other site 478801002079 dimer interface [polypeptide binding]; other site 478801002080 KMSKS motif; other site 478801002081 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 478801002082 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 478801002083 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 478801002084 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 478801002085 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 478801002086 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 478801002087 Substrate binding site; other site 478801002088 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 478801002089 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 478801002090 quinone interaction residues [chemical binding]; other site 478801002091 active site 478801002092 catalytic residues [active] 478801002093 FMN binding site [chemical binding]; other site 478801002094 substrate binding site [chemical binding]; other site 478801002095 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 478801002096 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 478801002097 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 478801002098 Walker A/P-loop; other site 478801002099 ATP binding site [chemical binding]; other site 478801002100 Q-loop/lid; other site 478801002101 ABC transporter signature motif; other site 478801002102 Walker B; other site 478801002103 D-loop; other site 478801002104 H-loop/switch region; other site 478801002105 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 478801002106 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 478801002107 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 478801002108 TM-ABC transporter signature motif; other site 478801002109 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 478801002110 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 478801002111 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 478801002112 TM-ABC transporter signature motif; other site 478801002113 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 478801002114 active site 478801002115 catalytic motif [active] 478801002116 Zn binding site [ion binding]; other site 478801002117 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 478801002118 Na2 binding site [ion binding]; other site 478801002119 putative substrate binding site 1 [chemical binding]; other site 478801002120 Na binding site 1 [ion binding]; other site 478801002121 putative substrate binding site 2 [chemical binding]; other site 478801002122 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 478801002123 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 478801002124 catalytic residues [active] 478801002125 catalytic nucleophile [active] 478801002126 Recombinase; Region: Recombinase; pfam07508 478801002127 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 478801002128 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 478801002129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 478801002130 Helix-turn-helix domain; Region: HTH_18; pfam12833 478801002131 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 478801002132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801002133 putative substrate translocation pore; other site 478801002134 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478801002135 dimerization interface [polypeptide binding]; other site 478801002136 putative DNA binding site [nucleotide binding]; other site 478801002137 putative Zn2+ binding site [ion binding]; other site 478801002138 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 478801002139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801002140 putative substrate translocation pore; other site 478801002141 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478801002142 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478801002143 TrwC relaxase; Region: TrwC; pfam08751 478801002144 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 478801002145 AAA domain; Region: AAA_30; pfam13604 478801002146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801002147 putative substrate translocation pore; other site 478801002148 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478801002149 dimerization interface [polypeptide binding]; other site 478801002150 putative DNA binding site [nucleotide binding]; other site 478801002151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801002152 putative substrate translocation pore; other site 478801002153 putative transposase OrfB; Reviewed; Region: PHA02517 478801002154 HTH-like domain; Region: HTH_21; pfam13276 478801002155 Integrase core domain; Region: rve; pfam00665 478801002156 Integrase core domain; Region: rve_3; pfam13683 478801002157 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 478801002158 DNA-binding interface [nucleotide binding]; DNA binding site 478801002159 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478801002160 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478801002161 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 478801002162 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 478801002163 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 478801002164 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 478801002165 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 478801002166 intersubunit interface [polypeptide binding]; other site 478801002167 active site 478801002168 catalytic residue [active] 478801002169 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 478801002170 active site 478801002171 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 478801002172 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 478801002173 active site 478801002174 substrate binding site [chemical binding]; other site 478801002175 metal binding site [ion binding]; metal-binding site 478801002176 purine nucleoside phosphorylase; Provisional; Region: PRK08202 478801002177 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 478801002178 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478801002179 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 478801002180 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 478801002181 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 478801002182 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 478801002183 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 478801002184 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 478801002185 carboxyltransferase (CT) interaction site; other site 478801002186 biotinylation site [posttranslational modification]; other site 478801002187 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 478801002188 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 478801002189 substrate binding site [chemical binding]; other site 478801002190 ATP binding site [chemical binding]; other site 478801002191 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478801002192 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478801002193 active site 478801002194 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 478801002195 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 478801002196 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 478801002197 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 478801002198 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 478801002199 FAD binding pocket [chemical binding]; other site 478801002200 FAD binding motif [chemical binding]; other site 478801002201 phosphate binding motif [ion binding]; other site 478801002202 NAD binding pocket [chemical binding]; other site 478801002203 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 478801002204 active site 478801002205 dimer interface [polypeptide binding]; other site 478801002206 Cupin domain; Region: Cupin_2; cl17218 478801002207 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 478801002208 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801002209 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 478801002210 Walker A/P-loop; other site 478801002211 ATP binding site [chemical binding]; other site 478801002212 Q-loop/lid; other site 478801002213 ABC transporter signature motif; other site 478801002214 Walker B; other site 478801002215 D-loop; other site 478801002216 H-loop/switch region; other site 478801002217 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 478801002218 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801002219 Walker A/P-loop; other site 478801002220 ATP binding site [chemical binding]; other site 478801002221 Q-loop/lid; other site 478801002222 ABC transporter signature motif; other site 478801002223 Walker B; other site 478801002224 D-loop; other site 478801002225 H-loop/switch region; other site 478801002226 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 478801002227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 478801002228 MOSC domain; Region: MOSC; pfam03473 478801002229 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 478801002230 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 478801002231 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 478801002232 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 478801002233 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 478801002234 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 478801002235 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 478801002236 cyclase homology domain; Region: CHD; cd07302 478801002237 nucleotidyl binding site; other site 478801002238 metal binding site [ion binding]; metal-binding site 478801002239 dimer interface [polypeptide binding]; other site 478801002240 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478801002241 enoyl-CoA hydratase; Provisional; Region: PRK07657 478801002242 substrate binding site [chemical binding]; other site 478801002243 oxyanion hole (OAH) forming residues; other site 478801002244 trimer interface [polypeptide binding]; other site 478801002245 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 478801002246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478801002247 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478801002248 active site 478801002249 phosphorylation site [posttranslational modification] 478801002250 intermolecular recognition site; other site 478801002251 dimerization interface [polypeptide binding]; other site 478801002252 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478801002253 DNA binding site [nucleotide binding] 478801002254 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 478801002255 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 478801002256 dimer interface [polypeptide binding]; other site 478801002257 phosphorylation site [posttranslational modification] 478801002258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478801002259 ATP binding site [chemical binding]; other site 478801002260 Mg2+ binding site [ion binding]; other site 478801002261 G-X-G motif; other site 478801002262 Predicted membrane protein [Function unknown]; Region: COG2246 478801002263 GtrA-like protein; Region: GtrA; pfam04138 478801002264 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 478801002265 ATP-grasp domain; Region: ATP-grasp; pfam02222 478801002266 AIR carboxylase; Region: AIRC; pfam00731 478801002267 LabA_like proteins; Region: LabA_like; cd06167 478801002268 putative metal binding site [ion binding]; other site 478801002269 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478801002270 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478801002271 active site 478801002272 AzlC protein; Region: AzlC; pfam03591 478801002273 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 478801002274 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 478801002275 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 478801002276 Ligand binding site; other site 478801002277 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 478801002278 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 478801002279 TIGR03089 family protein; Region: TIGR03089 478801002280 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 478801002281 Transcription factor WhiB; Region: Whib; pfam02467 478801002282 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 478801002283 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 478801002284 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 478801002285 active site 478801002286 substrate binding site [chemical binding]; other site 478801002287 metal binding site [ion binding]; metal-binding site 478801002288 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 478801002289 Bacterial phospho-glucose isomerase C-terminal region; Region: bact-PGI_C; pfam10432 478801002290 mycothione reductase; Reviewed; Region: PRK07846 478801002291 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478801002292 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 478801002293 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478801002294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478801002295 active site 478801002296 phosphorylation site [posttranslational modification] 478801002297 intermolecular recognition site; other site 478801002298 dimerization interface [polypeptide binding]; other site 478801002299 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478801002300 DNA binding site [nucleotide binding] 478801002301 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 478801002302 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 478801002303 dimerization interface [polypeptide binding]; other site 478801002304 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 478801002305 dimer interface [polypeptide binding]; other site 478801002306 phosphorylation site [posttranslational modification] 478801002307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478801002308 ATP binding site [chemical binding]; other site 478801002309 Mg2+ binding site [ion binding]; other site 478801002310 G-X-G motif; other site 478801002311 lipoprotein LpqB; Provisional; Region: PRK13613 478801002312 Sporulation and spore germination; Region: Germane; pfam10646 478801002313 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 478801002314 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 478801002315 30S subunit binding site; other site 478801002316 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 478801002317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 478801002318 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 478801002319 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 478801002320 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 478801002321 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 478801002322 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 478801002323 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 478801002324 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 478801002325 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 478801002326 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 478801002327 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 478801002328 nucleotide binding region [chemical binding]; other site 478801002329 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 478801002330 Helix-turn-helix domain; Region: HTH_17; pfam12728 478801002331 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 478801002332 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 478801002333 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 478801002334 NAD(P) binding site [chemical binding]; other site 478801002335 catalytic residues [active] 478801002336 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 478801002337 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 478801002338 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 478801002339 PAS fold; Region: PAS_4; pfam08448 478801002340 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 478801002341 Histidine kinase; Region: HisKA_2; pfam07568 478801002342 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 478801002343 Transcription factor WhiB; Region: Whib; pfam02467 478801002344 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 478801002345 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 478801002346 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 478801002347 catalytic site [active] 478801002348 putative active site [active] 478801002349 putative substrate binding site [chemical binding]; other site 478801002350 dimer interface [polypeptide binding]; other site 478801002351 Protease prsW family; Region: PrsW-protease; pfam13367 478801002352 Protein of unknown function, DUF258; Region: DUF258; pfam03193 478801002353 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 478801002354 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 478801002355 YfjP GTPase; Region: YfjP; cd11383 478801002356 G1 box; other site 478801002357 G1 box; other site 478801002358 GTP/Mg2+ binding site [chemical binding]; other site 478801002359 GTP/Mg2+ binding site [chemical binding]; other site 478801002360 Switch I region; other site 478801002361 G2 box; other site 478801002362 Switch II region; other site 478801002363 G3 box; other site 478801002364 G4 box; other site 478801002365 G5 box; other site 478801002366 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 478801002367 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 478801002368 dimer interface [polypeptide binding]; other site 478801002369 ssDNA binding site [nucleotide binding]; other site 478801002370 tetramer (dimer of dimers) interface [polypeptide binding]; other site 478801002371 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 478801002372 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801002373 Walker A/P-loop; other site 478801002374 ATP binding site [chemical binding]; other site 478801002375 Q-loop/lid; other site 478801002376 ABC transporter signature motif; other site 478801002377 Walker B; other site 478801002378 D-loop; other site 478801002379 H-loop/switch region; other site 478801002380 ABC transporter; Region: ABC_tran_2; pfam12848 478801002381 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 478801002382 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 478801002383 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 478801002384 active site 478801002385 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 478801002386 dimer interface [polypeptide binding]; other site 478801002387 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478801002388 C-terminal peptidase (prc); Region: prc; TIGR00225 478801002389 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 478801002390 Active site serine [active] 478801002391 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 478801002392 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 478801002393 active site 478801002394 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 478801002395 catalytic triad [active] 478801002396 dimer interface [polypeptide binding]; other site 478801002397 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 478801002398 active site 478801002399 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 478801002400 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 478801002401 active site 478801002402 ADP/pyrophosphate binding site [chemical binding]; other site 478801002403 dimerization interface [polypeptide binding]; other site 478801002404 allosteric effector site; other site 478801002405 fructose-1,6-bisphosphate binding site; other site 478801002406 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 478801002407 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 478801002408 active site 478801002409 catalytic site [active] 478801002410 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 478801002411 apolar tunnel; other site 478801002412 heme binding site [chemical binding]; other site 478801002413 dimerization interface [polypeptide binding]; other site 478801002414 Mechanosensitive ion channel; Region: MS_channel; pfam00924 478801002415 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 478801002416 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 478801002417 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 478801002418 Zn binding site [ion binding]; other site 478801002419 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 478801002420 catalytic residues [active] 478801002421 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 478801002422 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 478801002423 trigger factor; Provisional; Region: tig; PRK01490 478801002424 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 478801002425 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 478801002426 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 478801002427 Clp protease; Region: CLP_protease; pfam00574 478801002428 oligomer interface [polypeptide binding]; other site 478801002429 active site residues [active] 478801002430 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 478801002431 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 478801002432 oligomer interface [polypeptide binding]; other site 478801002433 active site residues [active] 478801002434 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 478801002435 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 478801002436 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478801002437 Walker A motif; other site 478801002438 ATP binding site [chemical binding]; other site 478801002439 Walker B motif; other site 478801002440 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 478801002441 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 478801002442 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 478801002443 active site 478801002444 HIGH motif; other site 478801002445 nucleotide binding site [chemical binding]; other site 478801002446 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 478801002447 active site 478801002448 KMSKS motif; other site 478801002449 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 478801002450 tRNA binding surface [nucleotide binding]; other site 478801002451 anticodon binding site; other site 478801002452 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 478801002453 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 478801002454 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 478801002455 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 478801002456 HIGH motif; other site 478801002457 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 478801002458 active site 478801002459 KMSKS motif; other site 478801002460 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 478801002461 tRNA binding surface [nucleotide binding]; other site 478801002462 anticodon binding site; other site 478801002463 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 478801002464 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 478801002465 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 478801002466 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 478801002467 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 478801002468 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 478801002469 active site 478801002470 multimer interface [polypeptide binding]; other site 478801002471 rod shape-determining protein MreB; Provisional; Region: PRK13927 478801002472 MreB and similar proteins; Region: MreB_like; cd10225 478801002473 nucleotide binding site [chemical binding]; other site 478801002474 Mg binding site [ion binding]; other site 478801002475 putative protofilament interaction site [polypeptide binding]; other site 478801002476 RodZ interaction site [polypeptide binding]; other site 478801002477 rod shape-determining protein MreC; Provisional; Region: PRK13922 478801002478 rod shape-determining protein MreC; Region: MreC; pfam04085 478801002479 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 478801002480 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 478801002481 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 478801002482 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 478801002483 16S/18S rRNA binding site [nucleotide binding]; other site 478801002484 S13e-L30e interaction site [polypeptide binding]; other site 478801002485 25S rRNA binding site [nucleotide binding]; other site 478801002486 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 478801002487 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 478801002488 oligomer interface [polypeptide binding]; other site 478801002489 RNA binding site [nucleotide binding]; other site 478801002490 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 478801002491 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 478801002492 RNase E interface [polypeptide binding]; other site 478801002493 trimer interface [polypeptide binding]; other site 478801002494 active site 478801002495 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 478801002496 putative nucleic acid binding region [nucleotide binding]; other site 478801002497 G-X-X-G motif; other site 478801002498 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 478801002499 RNA binding site [nucleotide binding]; other site 478801002500 domain interface; other site 478801002501 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478801002502 MULE transposase domain; Region: MULE; pfam10551 478801002503 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 478801002504 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 478801002505 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 478801002506 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 478801002507 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 478801002508 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 478801002509 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 478801002510 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 478801002511 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 478801002512 FAD binding pocket [chemical binding]; other site 478801002513 FAD binding motif [chemical binding]; other site 478801002514 phosphate binding motif [ion binding]; other site 478801002515 beta-alpha-beta structure motif; other site 478801002516 NAD(p) ribose binding residues [chemical binding]; other site 478801002517 NAD binding pocket [chemical binding]; other site 478801002518 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 478801002519 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 478801002520 catalytic loop [active] 478801002521 iron binding site [ion binding]; other site 478801002522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801002523 D-galactonate transporter; Region: 2A0114; TIGR00893 478801002524 putative substrate translocation pore; other site 478801002525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801002526 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 478801002527 nudix motif; other site 478801002528 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 478801002529 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 478801002530 folate binding site [chemical binding]; other site 478801002531 NADP+ binding site [chemical binding]; other site 478801002532 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 478801002533 dimer interface [polypeptide binding]; other site 478801002534 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 478801002535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478801002536 S-adenosylmethionine binding site [chemical binding]; other site 478801002537 thymidylate synthase; Reviewed; Region: thyA; PRK01827 478801002538 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 478801002539 dimerization interface [polypeptide binding]; other site 478801002540 active site 478801002541 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 478801002542 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 478801002543 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 478801002544 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 478801002545 Domain of unknown function DUF20; Region: UPF0118; pfam01594 478801002546 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 478801002547 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478801002548 dimer interface [polypeptide binding]; other site 478801002549 substrate binding site [chemical binding]; other site 478801002550 metal binding site [ion binding]; metal-binding site 478801002551 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 478801002552 RNA/DNA hybrid binding site [nucleotide binding]; other site 478801002553 active site 478801002554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 478801002555 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 478801002556 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 478801002557 active site 478801002558 putative acyltransferase; Provisional; Region: PRK05790 478801002559 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 478801002560 dimer interface [polypeptide binding]; other site 478801002561 active site 478801002562 Domain of unknown function DUF77; Region: DUF77; pfam01910 478801002563 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 478801002564 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 478801002565 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 478801002566 Walker A/P-loop; other site 478801002567 ATP binding site [chemical binding]; other site 478801002568 Q-loop/lid; other site 478801002569 ABC transporter signature motif; other site 478801002570 Walker B; other site 478801002571 D-loop; other site 478801002572 H-loop/switch region; other site 478801002573 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 478801002574 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 478801002575 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478801002576 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478801002577 active site 478801002578 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 478801002579 glycogen branching enzyme; Provisional; Region: PRK05402 478801002580 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 478801002581 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 478801002582 active site 478801002583 catalytic site [active] 478801002584 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 478801002585 trehalose synthase; Region: treS_nterm; TIGR02456 478801002586 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 478801002587 active site 478801002588 catalytic site [active] 478801002589 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 478801002590 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 478801002591 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 478801002592 active site 478801002593 catalytic site [active] 478801002594 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 478801002595 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 478801002596 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 478801002597 active site 478801002598 catalytic site [active] 478801002599 enoyl-CoA hydratase; Provisional; Region: PRK05862 478801002600 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478801002601 substrate binding site [chemical binding]; other site 478801002602 oxyanion hole (OAH) forming residues; other site 478801002603 trimer interface [polypeptide binding]; other site 478801002604 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 478801002605 Ligand binding site [chemical binding]; other site 478801002606 Electron transfer flavoprotein domain; Region: ETF; pfam01012 478801002607 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 478801002608 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 478801002609 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 478801002610 intracellular protease, PfpI family; Region: PfpI; TIGR01382 478801002611 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 478801002612 proposed catalytic triad [active] 478801002613 conserved cys residue [active] 478801002614 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 478801002615 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 478801002616 dimer interface [polypeptide binding]; other site 478801002617 motif 1; other site 478801002618 active site 478801002619 motif 2; other site 478801002620 motif 3; other site 478801002621 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 478801002622 anticodon binding site; other site 478801002623 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 478801002624 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 478801002625 tetramer interface [polypeptide binding]; other site 478801002626 heme binding pocket [chemical binding]; other site 478801002627 NADPH binding site [chemical binding]; other site 478801002628 Trp repressor protein; Region: Trp_repressor; cl17266 478801002629 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 478801002630 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 478801002631 HisG, C-terminal domain; Region: HisG_C; cl06867 478801002632 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 478801002633 histidinol dehydrogenase; Region: hisD; TIGR00069 478801002634 NAD binding site [chemical binding]; other site 478801002635 dimerization interface [polypeptide binding]; other site 478801002636 product binding site; other site 478801002637 substrate binding site [chemical binding]; other site 478801002638 zinc binding site [ion binding]; other site 478801002639 catalytic residues [active] 478801002640 histidinol-phosphate aminotransferase; Provisional; Region: PRK04781 478801002641 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 478801002642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478801002643 homodimer interface [polypeptide binding]; other site 478801002644 catalytic residue [active] 478801002645 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 478801002646 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478801002647 active site 478801002648 motif I; other site 478801002649 motif II; other site 478801002650 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 478801002651 putative active site pocket [active] 478801002652 4-fold oligomerization interface [polypeptide binding]; other site 478801002653 metal binding residues [ion binding]; metal-binding site 478801002654 3-fold/trimer interface [polypeptide binding]; other site 478801002655 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 478801002656 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 478801002657 putative active site [active] 478801002658 oxyanion strand; other site 478801002659 catalytic triad [active] 478801002660 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 478801002661 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 478801002662 catalytic residues [active] 478801002663 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 478801002664 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 478801002665 substrate binding site [chemical binding]; other site 478801002666 glutamase interaction surface [polypeptide binding]; other site 478801002667 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 478801002668 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 478801002669 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 478801002670 metal binding site [ion binding]; metal-binding site 478801002671 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 478801002672 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 478801002673 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478801002674 catalytic residue [active] 478801002675 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478801002676 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478801002677 active site 478801002678 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 478801002679 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 478801002680 Ligand Binding Site [chemical binding]; other site 478801002681 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 478801002682 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 478801002683 NAD(P) binding site [chemical binding]; other site 478801002684 catalytic residues [active] 478801002685 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 478801002686 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 478801002687 nucleotide binding pocket [chemical binding]; other site 478801002688 K-X-D-G motif; other site 478801002689 catalytic site [active] 478801002690 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 478801002691 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 478801002692 Helix-hairpin-helix motif; Region: HHH; pfam00633 478801002693 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 478801002694 Dimer interface [polypeptide binding]; other site 478801002695 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 478801002696 catalytic residues [active] 478801002697 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 478801002698 AAA domain; Region: AAA_17; pfam13207 478801002699 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 478801002700 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 478801002701 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 478801002702 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 478801002703 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 478801002704 GatB domain; Region: GatB_Yqey; smart00845 478801002705 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 478801002706 active site 478801002707 putative catalytic site [active] 478801002708 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478801002709 catalytic core [active] 478801002710 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 478801002711 putative ligand binding site [chemical binding]; other site 478801002712 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 478801002713 putative NAD binding site [chemical binding]; other site 478801002714 catalytic site [active] 478801002715 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 478801002716 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 478801002717 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 478801002718 homodimer interface [polypeptide binding]; other site 478801002719 substrate-cofactor binding pocket; other site 478801002720 catalytic residue [active] 478801002721 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 478801002722 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 478801002723 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 478801002724 glutamate racemase; Provisional; Region: PRK00865 478801002725 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 478801002726 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 478801002727 ribonuclease PH; Reviewed; Region: rph; PRK00173 478801002728 Ribonuclease PH; Region: RNase_PH_bact; cd11362 478801002729 hexamer interface [polypeptide binding]; other site 478801002730 active site 478801002731 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 478801002732 active site 478801002733 dimerization interface [polypeptide binding]; other site 478801002734 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 478801002735 aminotransferase; Validated; Region: PRK07777 478801002736 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 478801002737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478801002738 homodimer interface [polypeptide binding]; other site 478801002739 catalytic residue [active] 478801002740 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 478801002741 putative catalytic site [active] 478801002742 putative phosphate binding site [ion binding]; other site 478801002743 putative metal binding site [ion binding]; other site 478801002744 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 478801002745 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 478801002746 catalytic triad [active] 478801002747 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 478801002748 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 478801002749 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 478801002750 substrate-cofactor binding pocket; other site 478801002751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478801002752 catalytic residue [active] 478801002753 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 478801002754 active site 478801002755 NTP binding site [chemical binding]; other site 478801002756 metal binding triad [ion binding]; metal-binding site 478801002757 antibiotic binding site [chemical binding]; other site 478801002758 argininosuccinate lyase; Provisional; Region: PRK00855 478801002759 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 478801002760 active sites [active] 478801002761 tetramer interface [polypeptide binding]; other site 478801002762 argininosuccinate synthase; Validated; Region: PRK05370 478801002763 arginine repressor; Provisional; Region: PRK03341 478801002764 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 478801002765 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 478801002766 ornithine carbamoyltransferase; Provisional; Region: PRK00779 478801002767 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 478801002768 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 478801002769 Uncharacterized conserved protein [Function unknown]; Region: COG1359 478801002770 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 478801002771 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 478801002772 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 478801002773 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 478801002774 putative catalytic site [active] 478801002775 putative metal binding site [ion binding]; other site 478801002776 putative phosphate binding site [ion binding]; other site 478801002777 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 478801002778 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 478801002779 NAD(P) binding site [chemical binding]; other site 478801002780 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 478801002781 CoA-transferase family III; Region: CoA_transf_3; pfam02515 478801002782 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 478801002783 fructuronate transporter; Provisional; Region: PRK10034; cl15264 478801002784 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 478801002785 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 478801002786 NAD(P) binding site [chemical binding]; other site 478801002787 catalytic residues [active] 478801002788 SdpI/YhfL protein family; Region: SdpI; pfam13630 478801002789 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 478801002790 putative active site [active] 478801002791 Predicted membrane protein [Function unknown]; Region: COG2119 478801002792 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 478801002793 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 478801002794 SdpI/YhfL protein family; Region: SdpI; pfam13630 478801002795 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478801002796 NAD(P) binding site [chemical binding]; other site 478801002797 active site 478801002798 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 478801002799 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 478801002800 ATP binding site [chemical binding]; other site 478801002801 Walker A motif; other site 478801002802 hexamer interface [polypeptide binding]; other site 478801002803 Walker B motif; other site 478801002804 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 478801002805 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 478801002806 Beta-lactamase; Region: Beta-lactamase; pfam00144 478801002807 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478801002808 Beta-lactamase; Region: Beta-lactamase; pfam00144 478801002809 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 478801002810 peptide chain release factor 2; Validated; Region: prfB; PRK00578 478801002811 This domain is found in peptide chain release factors; Region: PCRF; smart00937 478801002812 RF-1 domain; Region: RF-1; pfam00472 478801002813 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 478801002814 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 478801002815 Walker A/P-loop; other site 478801002816 ATP binding site [chemical binding]; other site 478801002817 Q-loop/lid; other site 478801002818 ABC transporter signature motif; other site 478801002819 Walker B; other site 478801002820 D-loop; other site 478801002821 H-loop/switch region; other site 478801002822 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 478801002823 SmpB-tmRNA interface; other site 478801002824 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 478801002825 catalytic residues [active] 478801002826 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 478801002827 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 478801002828 Malic enzyme, N-terminal domain; Region: malic; pfam00390 478801002829 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 478801002830 putative NAD(P) binding site [chemical binding]; other site 478801002831 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 478801002832 DEAD-like helicases superfamily; Region: DEXDc; smart00487 478801002833 ATP binding site [chemical binding]; other site 478801002834 Mg++ binding site [ion binding]; other site 478801002835 motif III; other site 478801002836 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478801002837 nucleotide binding region [chemical binding]; other site 478801002838 ATP-binding site [chemical binding]; other site 478801002839 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 478801002840 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 478801002841 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478801002842 ATP binding site [chemical binding]; other site 478801002843 putative Mg++ binding site [ion binding]; other site 478801002844 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 478801002845 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 478801002846 active site 478801002847 DNA binding site [nucleotide binding] 478801002848 catalytic site [active] 478801002849 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 478801002850 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 478801002851 AsnC family; Region: AsnC_trans_reg; pfam01037 478801002852 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 478801002853 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 478801002854 dimer interface [polypeptide binding]; other site 478801002855 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 478801002856 active site 478801002857 Fe binding site [ion binding]; other site 478801002858 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 478801002859 putative homodimer interface [polypeptide binding]; other site 478801002860 putative homotetramer interface [polypeptide binding]; other site 478801002861 putative allosteric switch controlling residues; other site 478801002862 putative metal binding site [ion binding]; other site 478801002863 putative homodimer-homodimer interface [polypeptide binding]; other site 478801002864 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 478801002865 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 478801002866 metal-binding site [ion binding] 478801002867 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478801002868 Soluble P-type ATPase [General function prediction only]; Region: COG4087 478801002869 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 478801002870 metal-binding site [ion binding] 478801002871 fumarylacetoacetase; Region: PLN02856 478801002872 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 478801002873 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 478801002874 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 478801002875 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 478801002876 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 478801002877 active site 478801002878 catalytic triad [active] 478801002879 oxyanion hole [active] 478801002880 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 478801002881 Isochorismatase family; Region: Isochorismatase; pfam00857 478801002882 catalytic triad [active] 478801002883 metal binding site [ion binding]; metal-binding site 478801002884 conserved cis-peptide bond; other site 478801002885 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 478801002886 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 478801002887 active site 478801002888 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 478801002889 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 478801002890 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 478801002891 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 478801002892 HIGH motif; other site 478801002893 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 478801002894 active site 478801002895 KMSKS motif; other site 478801002896 Bacterial DNA-binding protein; Region: Bac_DNA_binding; pfam00216 478801002897 IHF - DNA interface [nucleotide binding]; other site 478801002898 IHF dimer interface [polypeptide binding]; other site 478801002899 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 478801002900 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 478801002901 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 478801002902 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 478801002903 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 478801002904 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 478801002905 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 478801002906 thiamine monophosphate kinase; Provisional; Region: PRK05731 478801002907 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 478801002908 ATP binding site [chemical binding]; other site 478801002909 dimerization interface [polypeptide binding]; other site 478801002910 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 478801002911 DAK2 domain; Region: Dak2; pfam02734 478801002912 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 478801002913 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 478801002914 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 478801002915 ssDNA binding site; other site 478801002916 generic binding surface II; other site 478801002917 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478801002918 ATP binding site [chemical binding]; other site 478801002919 putative Mg++ binding site [ion binding]; other site 478801002920 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478801002921 nucleotide binding region [chemical binding]; other site 478801002922 ATP-binding site [chemical binding]; other site 478801002923 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 478801002924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 478801002925 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 478801002926 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 478801002927 active site 478801002928 (T/H)XGH motif; other site 478801002929 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 478801002930 ribonuclease III; Reviewed; Region: rnc; PRK00102 478801002931 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 478801002932 dimerization interface [polypeptide binding]; other site 478801002933 active site 478801002934 metal binding site [ion binding]; metal-binding site 478801002935 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 478801002936 dsRNA binding site [nucleotide binding]; other site 478801002937 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 478801002938 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 478801002939 DNA binding site [nucleotide binding] 478801002940 catalytic residue [active] 478801002941 H2TH interface [polypeptide binding]; other site 478801002942 putative catalytic residues [active] 478801002943 turnover-facilitating residue; other site 478801002944 intercalation triad [nucleotide binding]; other site 478801002945 8OG recognition residue [nucleotide binding]; other site 478801002946 putative reading head residues; other site 478801002947 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 478801002948 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 478801002949 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 478801002950 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 478801002951 active site 478801002952 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 478801002953 Acylphosphatase; Region: Acylphosphatase; cl00551 478801002954 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 478801002955 AAA domain; Region: AAA_23; pfam13476 478801002956 Walker A/P-loop; other site 478801002957 ATP binding site [chemical binding]; other site 478801002958 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 478801002959 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 478801002960 ABC transporter signature motif; other site 478801002961 Walker B; other site 478801002962 D-loop; other site 478801002963 H-loop/switch region; other site 478801002964 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 478801002965 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 478801002966 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 478801002967 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 478801002968 signal recognition particle protein; Provisional; Region: PRK10867 478801002969 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 478801002970 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 478801002971 P loop; other site 478801002972 GTP binding site [chemical binding]; other site 478801002973 Signal peptide binding domain; Region: SRP_SPB; pfam02978 478801002974 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 478801002975 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 478801002976 inhibitor-cofactor binding pocket; inhibition site 478801002977 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478801002978 catalytic residue [active] 478801002979 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 478801002980 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 478801002981 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 478801002982 active site 478801002983 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 478801002984 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 478801002985 NAD(P) binding site [chemical binding]; other site 478801002986 catalytic residues [active] 478801002987 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 478801002988 Amidohydrolase; Region: Amidohydro_4; pfam13147 478801002989 active site 478801002990 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 478801002991 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 478801002992 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 478801002993 hypothetical protein; Provisional; Region: PRK02821 478801002994 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 478801002995 G-X-X-G motif; other site 478801002996 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 478801002997 RimM N-terminal domain; Region: RimM; pfam01782 478801002998 PRC-barrel domain; Region: PRC; pfam05239 478801002999 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 478801003000 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 478801003001 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 478801003002 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 478801003003 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 478801003004 Catalytic site [active] 478801003005 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 478801003006 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 478801003007 Catalytic site [active] 478801003008 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 478801003009 RNA/DNA hybrid binding site [nucleotide binding]; other site 478801003010 active site 478801003011 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 478801003012 hypothetical protein; Reviewed; Region: PRK12497 478801003013 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 478801003014 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 478801003015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478801003016 Walker A motif; other site 478801003017 ATP binding site [chemical binding]; other site 478801003018 Walker B motif; other site 478801003019 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 478801003020 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 478801003021 DNA protecting protein DprA; Region: dprA; TIGR00732 478801003022 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 478801003023 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 478801003024 active site 478801003025 DNA binding site [nucleotide binding] 478801003026 Int/Topo IB signature motif; other site 478801003027 Peptidase family M23; Region: Peptidase_M23; pfam01551 478801003028 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 478801003029 rRNA interaction site [nucleotide binding]; other site 478801003030 S8 interaction site; other site 478801003031 putative laminin-1 binding site; other site 478801003032 elongation factor Ts; Provisional; Region: tsf; PRK09377 478801003033 UBA/TS-N domain; Region: UBA; pfam00627 478801003034 Elongation factor TS; Region: EF_TS; pfam00889 478801003035 Elongation factor TS; Region: EF_TS; pfam00889 478801003036 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 478801003037 homohexameric interface [polypeptide binding]; other site 478801003038 uridine monophosphate binding site [chemical binding]; other site 478801003039 putative nucleotide binding site [chemical binding]; other site 478801003040 ribosome recycling factor; Reviewed; Region: frr; PRK00083 478801003041 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 478801003042 hinge region; other site 478801003043 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 478801003044 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 478801003045 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 478801003046 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478801003047 FeS/SAM binding site; other site 478801003048 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 478801003049 phosphate acetyltransferase; Reviewed; Region: PRK05632 478801003050 DRTGG domain; Region: DRTGG; pfam07085 478801003051 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 478801003052 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 478801003053 propionate/acetate kinase; Provisional; Region: PRK12379 478801003054 succinic semialdehyde dehydrogenase; Region: PLN02278 478801003055 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 478801003056 tetramerization interface [polypeptide binding]; other site 478801003057 NAD(P) binding site [chemical binding]; other site 478801003058 catalytic residues [active] 478801003059 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 478801003060 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 478801003061 active site 478801003062 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 478801003063 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 478801003064 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 478801003065 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 478801003066 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 478801003067 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 478801003068 active site 478801003069 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 478801003070 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 478801003071 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 478801003072 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 478801003073 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 478801003074 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 478801003075 Walker A/P-loop; other site 478801003076 ATP binding site [chemical binding]; other site 478801003077 Q-loop/lid; other site 478801003078 ABC transporter signature motif; other site 478801003079 Walker B; other site 478801003080 D-loop; other site 478801003081 H-loop/switch region; other site 478801003082 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 478801003083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478801003084 dimer interface [polypeptide binding]; other site 478801003085 conserved gate region; other site 478801003086 putative PBP binding loops; other site 478801003087 ABC-ATPase subunit interface; other site 478801003088 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 478801003089 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 478801003090 substrate binding pocket [chemical binding]; other site 478801003091 membrane-bound complex binding site; other site 478801003092 hinge residues; other site 478801003093 Predicted acetyltransferase [General function prediction only]; Region: COG3393 478801003094 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 478801003095 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 478801003096 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 478801003097 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 478801003098 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 478801003099 N- and C-terminal domain interface [polypeptide binding]; other site 478801003100 active site 478801003101 catalytic site [active] 478801003102 metal binding site [ion binding]; metal-binding site 478801003103 carbohydrate binding site [chemical binding]; other site 478801003104 ATP binding site [chemical binding]; other site 478801003105 prolyl-tRNA synthetase; Provisional; Region: PRK09194 478801003106 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 478801003107 dimer interface [polypeptide binding]; other site 478801003108 motif 1; other site 478801003109 active site 478801003110 motif 2; other site 478801003111 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 478801003112 putative deacylase active site [active] 478801003113 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 478801003114 active site 478801003115 motif 3; other site 478801003116 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 478801003117 anticodon binding site; other site 478801003118 hypothetical protein; Provisional; Region: PRK10621 478801003119 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 478801003120 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 478801003121 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 478801003122 putative active site [active] 478801003123 putative metal binding site [ion binding]; other site 478801003124 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 478801003125 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 478801003126 putative active site [active] 478801003127 putative metal binding site [ion binding]; other site 478801003128 ribosome maturation protein RimP; Reviewed; Region: PRK00092 478801003129 Sm and related proteins; Region: Sm_like; cl00259 478801003130 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 478801003131 putative RNA binding site [nucleotide binding]; other site 478801003132 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 478801003133 NusA N-terminal domain; Region: NusA_N; pfam08529 478801003134 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 478801003135 RNA binding site [nucleotide binding]; other site 478801003136 homodimer interface [polypeptide binding]; other site 478801003137 NusA-like KH domain; Region: KH_5; pfam13184 478801003138 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 478801003139 G-X-X-G motif; other site 478801003140 Protein of unknown function (DUF448); Region: DUF448; pfam04296 478801003141 putative RNA binding cleft [nucleotide binding]; other site 478801003142 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 478801003143 translation initiation factor IF-2; Region: IF-2; TIGR00487 478801003144 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 478801003145 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 478801003146 G1 box; other site 478801003147 putative GEF interaction site [polypeptide binding]; other site 478801003148 GTP/Mg2+ binding site [chemical binding]; other site 478801003149 Switch I region; other site 478801003150 G2 box; other site 478801003151 G3 box; other site 478801003152 Switch II region; other site 478801003153 G4 box; other site 478801003154 G5 box; other site 478801003155 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 478801003156 Translation-initiation factor 2; Region: IF-2; pfam11987 478801003157 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 478801003158 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 478801003159 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 478801003160 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 478801003161 RNA binding site [nucleotide binding]; other site 478801003162 active site 478801003163 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 478801003164 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 478801003165 active site 478801003166 Riboflavin kinase; Region: Flavokinase; pfam01687 478801003167 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 478801003168 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 478801003169 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 478801003170 homodimer interface [polypeptide binding]; other site 478801003171 oligonucleotide binding site [chemical binding]; other site 478801003172 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 478801003173 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 478801003174 GTPase CgtA; Reviewed; Region: obgE; PRK12296 478801003175 GTP1/OBG; Region: GTP1_OBG; pfam01018 478801003176 Obg GTPase; Region: Obg; cd01898 478801003177 G1 box; other site 478801003178 GTP/Mg2+ binding site [chemical binding]; other site 478801003179 Switch I region; other site 478801003180 G2 box; other site 478801003181 G3 box; other site 478801003182 Switch II region; other site 478801003183 G4 box; other site 478801003184 G5 box; other site 478801003185 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 478801003186 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 478801003187 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 478801003188 active site 478801003189 (T/H)XGH motif; other site 478801003190 Oligomerisation domain; Region: Oligomerisation; pfam02410 478801003191 CsbD-like; Region: CsbD; pfam05532 478801003192 GTP-binding protein LepA; Provisional; Region: PRK05433 478801003193 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 478801003194 G1 box; other site 478801003195 putative GEF interaction site [polypeptide binding]; other site 478801003196 GTP/Mg2+ binding site [chemical binding]; other site 478801003197 Switch I region; other site 478801003198 G2 box; other site 478801003199 G3 box; other site 478801003200 Switch II region; other site 478801003201 G4 box; other site 478801003202 G5 box; other site 478801003203 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 478801003204 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 478801003205 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 478801003206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478801003207 S-adenosylmethionine binding site [chemical binding]; other site 478801003208 hypothetical protein; Provisional; Region: PRK01346 478801003209 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478801003210 Coenzyme A binding pocket [chemical binding]; other site 478801003211 coproporphyrinogen III oxidase; Validated; Region: PRK05628 478801003212 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478801003213 FeS/SAM binding site; other site 478801003214 Tic20-like protein; Region: Tic20; pfam09685 478801003215 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 478801003216 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 478801003217 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 478801003218 chaperone protein DnaJ; Provisional; Region: PRK14278 478801003219 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 478801003220 HSP70 interaction site [polypeptide binding]; other site 478801003221 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 478801003222 Zn binding sites [ion binding]; other site 478801003223 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 478801003224 dimer interface [polypeptide binding]; other site 478801003225 RNA methyltransferase, RsmE family; Region: TIGR00046 478801003226 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 478801003227 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 478801003228 nucleotide binding site/active site [active] 478801003229 HIT family signature motif; other site 478801003230 catalytic residue [active] 478801003231 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 478801003232 PhoH-like protein; Region: PhoH; pfam02562 478801003233 metal-binding heat shock protein; Provisional; Region: PRK00016 478801003234 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 478801003235 Domain of unknown function DUF21; Region: DUF21; pfam01595 478801003236 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 478801003237 Transporter associated domain; Region: CorC_HlyC; smart01091 478801003238 GTPase Era; Reviewed; Region: era; PRK00089 478801003239 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 478801003240 G1 box; other site 478801003241 GTP/Mg2+ binding site [chemical binding]; other site 478801003242 Switch I region; other site 478801003243 G2 box; other site 478801003244 Switch II region; other site 478801003245 G3 box; other site 478801003246 G4 box; other site 478801003247 G5 box; other site 478801003248 KH domain; Region: KH_2; pfam07650 478801003249 G-X-X-G motif; other site 478801003250 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 478801003251 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 478801003252 Recombination protein O N terminal; Region: RecO_N; pfam11967 478801003253 Recombination protein O C terminal; Region: RecO_C; pfam02565 478801003254 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 478801003255 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 478801003256 catalytic residue [active] 478801003257 putative FPP diphosphate binding site; other site 478801003258 putative FPP binding hydrophobic cleft; other site 478801003259 dimer interface [polypeptide binding]; other site 478801003260 putative IPP diphosphate binding site; other site 478801003261 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 478801003262 metal binding site 2 [ion binding]; metal-binding site 478801003263 putative DNA binding helix; other site 478801003264 metal binding site 1 [ion binding]; metal-binding site 478801003265 dimer interface [polypeptide binding]; other site 478801003266 structural Zn2+ binding site [ion binding]; other site 478801003267 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 478801003268 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 478801003269 ABC-ATPase subunit interface; other site 478801003270 dimer interface [polypeptide binding]; other site 478801003271 putative PBP binding regions; other site 478801003272 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801003273 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 478801003274 Walker A/P-loop; other site 478801003275 ATP binding site [chemical binding]; other site 478801003276 Q-loop/lid; other site 478801003277 ABC transporter signature motif; other site 478801003278 Walker B; other site 478801003279 D-loop; other site 478801003280 H-loop/switch region; other site 478801003281 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 478801003282 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 478801003283 intersubunit interface [polypeptide binding]; other site 478801003284 glycyl-tRNA synthetase; Provisional; Region: PRK04173 478801003285 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 478801003286 motif 1; other site 478801003287 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 478801003288 active site 478801003289 motif 2; other site 478801003290 motif 3; other site 478801003291 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 478801003292 anticodon binding site; other site 478801003293 Lysine efflux permease [General function prediction only]; Region: COG1279 478801003294 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 478801003295 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 478801003296 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 478801003297 dimerization interface [polypeptide binding]; other site 478801003298 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 478801003299 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 478801003300 FMN binding site [chemical binding]; other site 478801003301 active site 478801003302 catalytic residues [active] 478801003303 substrate binding site [chemical binding]; other site 478801003304 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 478801003305 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 478801003306 active site residue [active] 478801003307 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 478801003308 active site residue [active] 478801003309 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 478801003310 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 478801003311 active site 478801003312 catalytic tetrad [active] 478801003313 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 478801003314 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 478801003315 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 478801003316 Zn2+ binding site [ion binding]; other site 478801003317 Mg2+ binding site [ion binding]; other site 478801003318 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 478801003319 DNA primase; Validated; Region: dnaG; PRK05667 478801003320 CHC2 zinc finger; Region: zf-CHC2; pfam01807 478801003321 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 478801003322 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 478801003323 active site 478801003324 metal binding site [ion binding]; metal-binding site 478801003325 interdomain interaction site; other site 478801003326 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 478801003327 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 478801003328 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 478801003329 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 478801003330 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 478801003331 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 478801003332 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 478801003333 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 478801003334 dimer interface [polypeptide binding]; other site 478801003335 active site 478801003336 acyl carrier protein; Provisional; Region: acpP; PRK00982 478801003337 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 478801003338 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 478801003339 dimer interface [polypeptide binding]; other site 478801003340 active site 478801003341 CoA binding pocket [chemical binding]; other site 478801003342 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 478801003343 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 478801003344 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 478801003345 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 478801003346 carboxyltransferase (CT) interaction site; other site 478801003347 biotinylation site [posttranslational modification]; other site 478801003348 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 478801003349 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 478801003350 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 478801003351 putative active site [active] 478801003352 catalytic site [active] 478801003353 putative metal binding site [ion binding]; other site 478801003354 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 478801003355 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 478801003356 dimer interface [polypeptide binding]; other site 478801003357 TPP-binding site [chemical binding]; other site 478801003358 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 478801003359 Uncharacterized conserved protein [Function unknown]; Region: COG0327 478801003360 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 478801003361 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 478801003362 catalytic core [active] 478801003363 Protein of unknown function (DUF328); Region: DUF328; cl01143 478801003364 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 478801003365 RNB domain; Region: RNB; pfam00773 478801003366 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 478801003367 RNA binding site [nucleotide binding]; other site 478801003368 Excalibur calcium-binding domain; Region: Excalibur; smart00894 478801003369 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 478801003370 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 478801003371 nucleotide binding site [chemical binding]; other site 478801003372 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 478801003373 active site 478801003374 acetylornithine deacetylase; Validated; Region: PRK06915 478801003375 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 478801003376 metal binding site [ion binding]; metal-binding site 478801003377 dimer interface [polypeptide binding]; other site 478801003378 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 478801003379 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 478801003380 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 478801003381 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 478801003382 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 478801003383 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 478801003384 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 478801003385 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 478801003386 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 478801003387 metal binding triad; other site 478801003388 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 478801003389 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 478801003390 metal binding triad; other site 478801003391 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 478801003392 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 478801003393 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 478801003394 phosphate binding site [ion binding]; other site 478801003395 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 478801003396 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 478801003397 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 478801003398 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 478801003399 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 478801003400 23S rRNA binding site [nucleotide binding]; other site 478801003401 L21 binding site [polypeptide binding]; other site 478801003402 L13 binding site [polypeptide binding]; other site 478801003403 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 478801003404 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 478801003405 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 478801003406 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 478801003407 dimer interface [polypeptide binding]; other site 478801003408 motif 1; other site 478801003409 active site 478801003410 motif 2; other site 478801003411 motif 3; other site 478801003412 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 478801003413 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 478801003414 putative tRNA-binding site [nucleotide binding]; other site 478801003415 B3/4 domain; Region: B3_4; pfam03483 478801003416 tRNA synthetase B5 domain; Region: B5; smart00874 478801003417 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 478801003418 dimer interface [polypeptide binding]; other site 478801003419 motif 1; other site 478801003420 motif 3; other site 478801003421 motif 2; other site 478801003422 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 478801003423 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 478801003424 classical (c) SDRs; Region: SDR_c; cd05233 478801003425 NAD(P) binding site [chemical binding]; other site 478801003426 active site 478801003427 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 478801003428 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 478801003429 active site 478801003430 HIGH motif; other site 478801003431 dimer interface [polypeptide binding]; other site 478801003432 KMSKS motif; other site 478801003433 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 478801003434 RNA binding surface [nucleotide binding]; other site 478801003435 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 478801003436 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 478801003437 RNA binding surface [nucleotide binding]; other site 478801003438 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 478801003439 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 478801003440 ATP-NAD kinase; Region: NAD_kinase; pfam01513 478801003441 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 478801003442 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 478801003443 Walker A/P-loop; other site 478801003444 ATP binding site [chemical binding]; other site 478801003445 Q-loop/lid; other site 478801003446 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 478801003447 ABC transporter signature motif; other site 478801003448 Walker B; other site 478801003449 D-loop; other site 478801003450 H-loop/switch region; other site 478801003451 CTP synthetase; Validated; Region: pyrG; PRK05380 478801003452 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 478801003453 Catalytic site [active] 478801003454 active site 478801003455 UTP binding site [chemical binding]; other site 478801003456 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 478801003457 active site 478801003458 putative oxyanion hole; other site 478801003459 catalytic triad [active] 478801003460 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 478801003461 dimer interface [polypeptide binding]; other site 478801003462 ADP-ribose binding site [chemical binding]; other site 478801003463 active site 478801003464 nudix motif; other site 478801003465 metal binding site [ion binding]; metal-binding site 478801003466 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 478801003467 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 478801003468 dimer interface [polypeptide binding]; other site 478801003469 anticodon binding site; other site 478801003470 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 478801003471 homodimer interface [polypeptide binding]; other site 478801003472 motif 1; other site 478801003473 active site 478801003474 motif 2; other site 478801003475 GAD domain; Region: GAD; pfam02938 478801003476 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 478801003477 active site 478801003478 motif 3; other site 478801003479 replication factor C small subunit 2; Reviewed; Region: PRK12402 478801003480 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478801003481 Walker A motif; other site 478801003482 ATP binding site [chemical binding]; other site 478801003483 Walker B motif; other site 478801003484 arginine finger; other site 478801003485 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 478801003486 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 478801003487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478801003488 dimer interface [polypeptide binding]; other site 478801003489 conserved gate region; other site 478801003490 putative PBP binding loops; other site 478801003491 ABC-ATPase subunit interface; other site 478801003492 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 478801003493 peptide binding site [polypeptide binding]; other site 478801003494 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 478801003495 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 478801003496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478801003497 dimer interface [polypeptide binding]; other site 478801003498 conserved gate region; other site 478801003499 putative PBP binding loops; other site 478801003500 ABC-ATPase subunit interface; other site 478801003501 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 478801003502 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 478801003503 Walker A/P-loop; other site 478801003504 ATP binding site [chemical binding]; other site 478801003505 Q-loop/lid; other site 478801003506 ABC transporter signature motif; other site 478801003507 Walker B; other site 478801003508 D-loop; other site 478801003509 H-loop/switch region; other site 478801003510 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 478801003511 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 478801003512 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 478801003513 Walker A/P-loop; other site 478801003514 ATP binding site [chemical binding]; other site 478801003515 Q-loop/lid; other site 478801003516 ABC transporter signature motif; other site 478801003517 Walker B; other site 478801003518 D-loop; other site 478801003519 H-loop/switch region; other site 478801003520 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 478801003521 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 478801003522 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 478801003523 motif 1; other site 478801003524 active site 478801003525 motif 2; other site 478801003526 motif 3; other site 478801003527 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 478801003528 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 478801003529 YceG-like family; Region: YceG; pfam02618 478801003530 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 478801003531 dimerization interface [polypeptide binding]; other site 478801003532 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 478801003533 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 478801003534 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 478801003535 NAD(P) binding site [chemical binding]; other site 478801003536 shikimate binding site; other site 478801003537 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 478801003538 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 478801003539 Tetramer interface [polypeptide binding]; other site 478801003540 active site 478801003541 FMN-binding site [chemical binding]; other site 478801003542 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 478801003543 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 478801003544 ADP binding site [chemical binding]; other site 478801003545 magnesium binding site [ion binding]; other site 478801003546 putative shikimate binding site; other site 478801003547 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 478801003548 active site 478801003549 dimer interface [polypeptide binding]; other site 478801003550 metal binding site [ion binding]; metal-binding site 478801003551 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 478801003552 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 478801003553 Walker A/P-loop; other site 478801003554 ATP binding site [chemical binding]; other site 478801003555 Q-loop/lid; other site 478801003556 ABC transporter signature motif; other site 478801003557 Walker B; other site 478801003558 D-loop; other site 478801003559 H-loop/switch region; other site 478801003560 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 478801003561 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 478801003562 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 478801003563 Walker A/P-loop; other site 478801003564 ATP binding site [chemical binding]; other site 478801003565 Q-loop/lid; other site 478801003566 ABC transporter signature motif; other site 478801003567 Walker B; other site 478801003568 D-loop; other site 478801003569 H-loop/switch region; other site 478801003570 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 478801003571 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 478801003572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478801003573 dimer interface [polypeptide binding]; other site 478801003574 conserved gate region; other site 478801003575 putative PBP binding loops; other site 478801003576 ABC-ATPase subunit interface; other site 478801003577 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 478801003578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478801003579 dimer interface [polypeptide binding]; other site 478801003580 conserved gate region; other site 478801003581 putative PBP binding loops; other site 478801003582 ABC-ATPase subunit interface; other site 478801003583 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 478801003584 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 478801003585 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 478801003586 active site 478801003587 FMN binding site [chemical binding]; other site 478801003588 substrate binding site [chemical binding]; other site 478801003589 3Fe-4S cluster binding site [ion binding]; other site 478801003590 elongation factor P; Validated; Region: PRK00529 478801003591 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 478801003592 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 478801003593 RNA binding site [nucleotide binding]; other site 478801003594 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 478801003595 RNA binding site [nucleotide binding]; other site 478801003596 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 478801003597 putative RNA binding site [nucleotide binding]; other site 478801003598 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 478801003599 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 478801003600 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 478801003601 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 478801003602 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 478801003603 dihydroorotase, multifunctional complex type; Region: pyrC_multi; TIGR00857 478801003604 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 478801003605 active site 478801003606 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 478801003607 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 478801003608 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 478801003609 catalytic site [active] 478801003610 subunit interface [polypeptide binding]; other site 478801003611 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 478801003612 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 478801003613 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 478801003614 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 478801003615 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 478801003616 ATP-grasp domain; Region: ATP-grasp_4; cl17255 478801003617 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 478801003618 IMP binding site; other site 478801003619 dimer interface [polypeptide binding]; other site 478801003620 interdomain contacts; other site 478801003621 partial ornithine binding site; other site 478801003622 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 478801003623 active site 478801003624 dimer interface [polypeptide binding]; other site 478801003625 Guanylate kinase; Region: Guanylate_kin; pfam00625 478801003626 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 478801003627 catalytic site [active] 478801003628 G-X2-G-X-G-K; other site 478801003629 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 478801003630 Flavoprotein; Region: Flavoprotein; pfam02441 478801003631 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 478801003632 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 478801003633 S-adenosylmethionine synthetase; Validated; Region: PRK05250 478801003634 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 478801003635 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 478801003636 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 478801003637 primosome assembly protein PriA; Provisional; Region: PRK14873 478801003638 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 478801003639 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 478801003640 putative active site [active] 478801003641 substrate binding site [chemical binding]; other site 478801003642 putative cosubstrate binding site; other site 478801003643 catalytic site [active] 478801003644 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 478801003645 substrate binding site [chemical binding]; other site 478801003646 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 478801003647 16S rRNA methyltransferase B; Provisional; Region: PRK14902 478801003648 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 478801003649 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 478801003650 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 478801003651 substrate binding site [chemical binding]; other site 478801003652 hexamer interface [polypeptide binding]; other site 478801003653 metal binding site [ion binding]; metal-binding site 478801003654 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 478801003655 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 478801003656 hypothetical protein; Provisional; Region: PRK06547 478801003657 TIGR03085 family protein; Region: TIGR03085 478801003658 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 478801003659 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 478801003660 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 478801003661 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801003662 Walker A/P-loop; other site 478801003663 ATP binding site [chemical binding]; other site 478801003664 Q-loop/lid; other site 478801003665 ABC transporter signature motif; other site 478801003666 Walker B; other site 478801003667 D-loop; other site 478801003668 H-loop/switch region; other site 478801003669 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 478801003670 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 478801003671 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801003672 Walker A/P-loop; other site 478801003673 ATP binding site [chemical binding]; other site 478801003674 Q-loop/lid; other site 478801003675 ABC transporter signature motif; other site 478801003676 Walker B; other site 478801003677 D-loop; other site 478801003678 H-loop/switch region; other site 478801003679 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850 478801003680 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 478801003681 active site 478801003682 ribulose/triose binding site [chemical binding]; other site 478801003683 phosphate binding site [ion binding]; other site 478801003684 substrate (anthranilate) binding pocket [chemical binding]; other site 478801003685 product (indole) binding pocket [chemical binding]; other site 478801003686 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 478801003687 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 478801003688 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478801003689 catalytic residue [active] 478801003690 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 478801003691 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 478801003692 substrate binding site [chemical binding]; other site 478801003693 active site 478801003694 catalytic residues [active] 478801003695 heterodimer interface [polypeptide binding]; other site 478801003696 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 478801003697 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 478801003698 catalytic residues [active] 478801003699 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 478801003700 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 478801003701 pyruvate kinase; Provisional; Region: PRK06247 478801003702 domain interfaces; other site 478801003703 active site 478801003704 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 478801003705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478801003706 active site 478801003707 phosphorylation site [posttranslational modification] 478801003708 intermolecular recognition site; other site 478801003709 dimerization interface [polypeptide binding]; other site 478801003710 ANTAR domain; Region: ANTAR; pfam03861 478801003711 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 478801003712 CoenzymeA binding site [chemical binding]; other site 478801003713 subunit interaction site [polypeptide binding]; other site 478801003714 PHB binding site; other site 478801003715 DNA polymerase I; Provisional; Region: PRK05755 478801003716 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 478801003717 active site 478801003718 metal binding site 1 [ion binding]; metal-binding site 478801003719 putative 5' ssDNA interaction site; other site 478801003720 metal binding site 3; metal-binding site 478801003721 metal binding site 2 [ion binding]; metal-binding site 478801003722 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 478801003723 putative DNA binding site [nucleotide binding]; other site 478801003724 putative metal binding site [ion binding]; other site 478801003725 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 478801003726 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 478801003727 active site 478801003728 DNA binding site [nucleotide binding] 478801003729 catalytic site [active] 478801003730 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 478801003731 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 478801003732 Potassium binding sites [ion binding]; other site 478801003733 Cesium cation binding sites [ion binding]; other site 478801003734 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 478801003735 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 478801003736 RNA binding site [nucleotide binding]; other site 478801003737 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 478801003738 RNA binding site [nucleotide binding]; other site 478801003739 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 478801003740 RNA binding site [nucleotide binding]; other site 478801003741 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 478801003742 RNA binding site [nucleotide binding]; other site 478801003743 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 478801003744 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 478801003745 CoA-binding site [chemical binding]; other site 478801003746 ATP-binding [chemical binding]; other site 478801003747 BCCT family transporter; Region: BCCT; pfam02028 478801003748 excinuclease ABC subunit B; Provisional; Region: PRK05298 478801003749 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478801003750 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478801003751 nucleotide binding region [chemical binding]; other site 478801003752 ATP-binding site [chemical binding]; other site 478801003753 Ultra-violet resistance protein B; Region: UvrB; pfam12344 478801003754 UvrB/uvrC motif; Region: UVR; pfam02151 478801003755 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 478801003756 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 478801003757 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 478801003758 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 478801003759 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 478801003760 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 478801003761 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 478801003762 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 478801003763 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 478801003764 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 478801003765 GIY-YIG motif/motif A; other site 478801003766 active site 478801003767 catalytic site [active] 478801003768 putative DNA binding site [nucleotide binding]; other site 478801003769 metal binding site [ion binding]; metal-binding site 478801003770 UvrB/uvrC motif; Region: UVR; pfam02151 478801003771 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 478801003772 Helix-hairpin-helix motif; Region: HHH; pfam00633 478801003773 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 478801003774 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 478801003775 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 478801003776 phosphate binding site [ion binding]; other site 478801003777 putative substrate binding pocket [chemical binding]; other site 478801003778 dimer interface [polypeptide binding]; other site 478801003779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 478801003780 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 478801003781 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 478801003782 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 478801003783 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 478801003784 Phosphoglycerate kinase; Region: PGK; pfam00162 478801003785 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 478801003786 substrate binding site [chemical binding]; other site 478801003787 hinge regions; other site 478801003788 ADP binding site [chemical binding]; other site 478801003789 catalytic site [active] 478801003790 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 478801003791 triosephosphate isomerase; Provisional; Region: PRK14567 478801003792 substrate binding site [chemical binding]; other site 478801003793 dimer interface [polypeptide binding]; other site 478801003794 catalytic triad [active] 478801003795 Preprotein translocase SecG subunit; Region: SecG; pfam03840 478801003796 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 478801003797 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 478801003798 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 478801003799 putative active site [active] 478801003800 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 478801003801 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 478801003802 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 478801003803 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 478801003804 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 478801003805 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 478801003806 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 478801003807 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 478801003808 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 478801003809 putative active site [active] 478801003810 transaldolase; Provisional; Region: PRK03903 478801003811 catalytic residue [active] 478801003812 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 478801003813 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 478801003814 TPP-binding site [chemical binding]; other site 478801003815 dimer interface [polypeptide binding]; other site 478801003816 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 478801003817 PYR/PP interface [polypeptide binding]; other site 478801003818 dimer interface [polypeptide binding]; other site 478801003819 TPP binding site [chemical binding]; other site 478801003820 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 478801003821 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 478801003822 UbiA prenyltransferase family; Region: UbiA; pfam01040 478801003823 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 478801003824 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801003825 Walker A/P-loop; other site 478801003826 ATP binding site [chemical binding]; other site 478801003827 Q-loop/lid; other site 478801003828 ABC transporter signature motif; other site 478801003829 Walker B; other site 478801003830 D-loop; other site 478801003831 H-loop/switch region; other site 478801003832 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 478801003833 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 478801003834 ABC-2 type transporter; Region: ABC2_membrane; cl17235 478801003835 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 478801003836 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 478801003837 Walker A/P-loop; other site 478801003838 ATP binding site [chemical binding]; other site 478801003839 Q-loop/lid; other site 478801003840 ABC transporter signature motif; other site 478801003841 Walker B; other site 478801003842 D-loop; other site 478801003843 H-loop/switch region; other site 478801003844 Predicted transcriptional regulator [Transcription]; Region: COG2345 478801003845 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478801003846 putative DNA binding site [nucleotide binding]; other site 478801003847 putative Zn2+ binding site [ion binding]; other site 478801003848 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 478801003849 FeS assembly protein SufB; Region: sufB; TIGR01980 478801003850 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 478801003851 FeS assembly protein SufD; Region: sufD; TIGR01981 478801003852 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 478801003853 [2Fe-2S] cluster binding site [ion binding]; other site 478801003854 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 478801003855 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 478801003856 Walker A/P-loop; other site 478801003857 ATP binding site [chemical binding]; other site 478801003858 Q-loop/lid; other site 478801003859 ABC transporter signature motif; other site 478801003860 Walker B; other site 478801003861 D-loop; other site 478801003862 H-loop/switch region; other site 478801003863 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 478801003864 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 478801003865 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478801003866 catalytic residue [active] 478801003867 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 478801003868 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 478801003869 trimerization site [polypeptide binding]; other site 478801003870 active site 478801003871 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 478801003872 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 478801003873 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 478801003874 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 478801003875 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 478801003876 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 478801003877 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801003878 Walker A/P-loop; other site 478801003879 ATP binding site [chemical binding]; other site 478801003880 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 478801003881 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 478801003882 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 478801003883 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478801003884 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 478801003885 NAD(P) binding site [chemical binding]; other site 478801003886 active site 478801003887 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 478801003888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478801003889 NAD(P) binding site [chemical binding]; other site 478801003890 active site 478801003891 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 478801003892 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 478801003893 Tetratrico peptide repeat; Region: TPR_5; pfam12688 478801003894 cyanophycin synthetase; Provisional; Region: PRK14016 478801003895 ATP-grasp domain; Region: ATP-grasp_4; cl17255 478801003896 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 478801003897 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 478801003898 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 478801003899 proposed catalytic triad [active] 478801003900 active site nucleophile [active] 478801003901 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 478801003902 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801003903 Walker A/P-loop; other site 478801003904 ATP binding site [chemical binding]; other site 478801003905 Q-loop/lid; other site 478801003906 ABC transporter signature motif; other site 478801003907 Walker B; other site 478801003908 D-loop; other site 478801003909 H-loop/switch region; other site 478801003910 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 478801003911 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 478801003912 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 478801003913 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 478801003914 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 478801003915 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 478801003916 putative acyl-acceptor binding pocket; other site 478801003917 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478801003918 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 478801003919 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 478801003920 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478801003921 DNA binding residues [nucleotide binding] 478801003922 DNA polymerase IV; Provisional; Region: PRK03348 478801003923 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 478801003924 active site 478801003925 DNA binding site [nucleotide binding] 478801003926 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 478801003927 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 478801003928 putative active site [active] 478801003929 metal binding site [ion binding]; metal-binding site 478801003930 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 478801003931 HsdM N-terminal domain; Region: HsdM_N; pfam12161 478801003932 Methyltransferase domain; Region: Methyltransf_26; pfam13659 478801003933 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 478801003934 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 478801003935 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 478801003936 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478801003937 ATP binding site [chemical binding]; other site 478801003938 putative Mg++ binding site [ion binding]; other site 478801003939 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 478801003940 TIR domain; Region: TIR_2; pfam13676 478801003941 Caspase domain; Region: Peptidase_C14; pfam00656 478801003942 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 478801003943 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 478801003944 active site 478801003945 metal binding site [ion binding]; metal-binding site 478801003946 nudix motif; other site 478801003947 prenyltransferase; Reviewed; Region: ubiA; PRK13105 478801003948 UbiA prenyltransferase family; Region: UbiA; pfam01040 478801003949 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 478801003950 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 478801003951 phytoene desaturase; Region: crtI_fam; TIGR02734 478801003952 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 478801003953 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 478801003954 active site lid residues [active] 478801003955 substrate binding pocket [chemical binding]; other site 478801003956 catalytic residues [active] 478801003957 substrate-Mg2+ binding site; other site 478801003958 aspartate-rich region 1; other site 478801003959 aspartate-rich region 2; other site 478801003960 hypothetical protein; Provisional; Region: PRK07906 478801003961 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 478801003962 putative metal binding site [ion binding]; other site 478801003963 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 478801003964 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 478801003965 oligomer interface [polypeptide binding]; other site 478801003966 metal binding site [ion binding]; metal-binding site 478801003967 metal binding site [ion binding]; metal-binding site 478801003968 putative Cl binding site [ion binding]; other site 478801003969 basic sphincter; other site 478801003970 hydrophobic gate; other site 478801003971 periplasmic entrance; other site 478801003972 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 478801003973 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 478801003974 active site 478801003975 HIGH motif; other site 478801003976 nucleotide binding site [chemical binding]; other site 478801003977 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 478801003978 active site 478801003979 KMSKS motif; other site 478801003980 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 478801003981 tRNA binding surface [nucleotide binding]; other site 478801003982 anticodon binding site; other site 478801003983 PAC2 family; Region: PAC2; pfam09754 478801003984 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 478801003985 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478801003986 motif II; other site 478801003987 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 478801003988 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 478801003989 nudix motif; other site 478801003990 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 478801003991 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 478801003992 Peptidase family M50; Region: Peptidase_M50; pfam02163 478801003993 active site 478801003994 putative substrate binding region [chemical binding]; other site 478801003995 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 478801003996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478801003997 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 478801003998 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 478801003999 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 478801004000 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 478801004001 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 478801004002 Predicted transcriptional regulator [Transcription]; Region: COG2378 478801004003 WYL domain; Region: WYL; pfam13280 478801004004 Predicted transcriptional regulator [Transcription]; Region: COG2378 478801004005 WYL domain; Region: WYL; pfam13280 478801004006 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 478801004007 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 478801004008 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 478801004009 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478801004010 ATP binding site [chemical binding]; other site 478801004011 putative Mg++ binding site [ion binding]; other site 478801004012 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 478801004013 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478801004014 nucleotide binding region [chemical binding]; other site 478801004015 ATP-binding site [chemical binding]; other site 478801004016 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 478801004017 5'-3' exonuclease; Region: 53EXOc; smart00475 478801004018 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 478801004019 active site 478801004020 metal binding site 1 [ion binding]; metal-binding site 478801004021 putative 5' ssDNA interaction site; other site 478801004022 metal binding site 3; metal-binding site 478801004023 metal binding site 2 [ion binding]; metal-binding site 478801004024 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 478801004025 putative DNA binding site [nucleotide binding]; other site 478801004026 putative metal binding site [ion binding]; other site 478801004027 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 478801004028 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478801004029 putative DNA binding site [nucleotide binding]; other site 478801004030 putative Zn2+ binding site [ion binding]; other site 478801004031 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 478801004032 putative deacylase active site [active] 478801004033 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 478801004034 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 478801004035 active site 478801004036 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 478801004037 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 478801004038 putative active site [active] 478801004039 catalytic triad [active] 478801004040 putative dimer interface [polypeptide binding]; other site 478801004041 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 478801004042 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 478801004043 Ligand binding site; other site 478801004044 Putative Catalytic site; other site 478801004045 DXD motif; other site 478801004046 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 478801004047 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 478801004048 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 478801004049 Domain of unknown function DUF20; Region: UPF0118; pfam01594 478801004050 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 478801004051 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 478801004052 putative active site [active] 478801004053 putative metal binding site [ion binding]; other site 478801004054 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 478801004055 lipid kinase; Reviewed; Region: PRK13054 478801004056 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 478801004057 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 478801004058 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478801004059 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478801004060 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478801004061 TIGR01777 family protein; Region: yfcH 478801004062 NAD(P) binding site [chemical binding]; other site 478801004063 active site 478801004064 Phosphotransferase enzyme family; Region: APH; pfam01636 478801004065 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 478801004066 active site 478801004067 ATP binding site [chemical binding]; other site 478801004068 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 478801004069 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 478801004070 synthetase active site [active] 478801004071 NTP binding site [chemical binding]; other site 478801004072 metal binding site [ion binding]; metal-binding site 478801004073 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 478801004074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801004075 Walker A/P-loop; other site 478801004076 ATP binding site [chemical binding]; other site 478801004077 Q-loop/lid; other site 478801004078 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 478801004079 ABC transporter signature motif; other site 478801004080 Walker B; other site 478801004081 D-loop; other site 478801004082 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 478801004083 aspartate aminotransferase; Provisional; Region: PRK06108 478801004084 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 478801004085 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 478801004086 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478801004087 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478801004088 active site 478801004089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478801004090 S-adenosylmethionine binding site [chemical binding]; other site 478801004091 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 478801004092 YCII-related domain; Region: YCII; cl00999 478801004093 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 478801004094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478801004095 S-adenosylmethionine binding site [chemical binding]; other site 478801004096 Phosphotransferase enzyme family; Region: APH; pfam01636 478801004097 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 478801004098 active site 478801004099 ATP binding site [chemical binding]; other site 478801004100 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 478801004101 NIPSNAP; Region: NIPSNAP; pfam07978 478801004102 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478801004103 MULE transposase domain; Region: MULE; pfam10551 478801004104 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 478801004105 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 478801004106 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 478801004107 active site 478801004108 substrate binding site [chemical binding]; other site 478801004109 ATP binding site [chemical binding]; other site 478801004110 Phosphotransferase enzyme family; Region: APH; pfam01636 478801004111 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 478801004112 aromatic arch; other site 478801004113 DCoH dimer interaction site [polypeptide binding]; other site 478801004114 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 478801004115 DCoH tetramer interaction site [polypeptide binding]; other site 478801004116 substrate binding site [chemical binding]; other site 478801004117 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 478801004118 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 478801004119 active site 478801004120 CGNR zinc finger; Region: zf-CGNR; pfam11706 478801004121 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 478801004122 B3/4 domain; Region: B3_4; smart00873 478801004123 B3/4 domain; Region: B3_4; pfam03483 478801004124 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 478801004125 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478801004126 Coenzyme A binding pocket [chemical binding]; other site 478801004127 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 478801004128 nudix motif; other site 478801004129 hypothetical protein; Provisional; Region: PRK09256 478801004130 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 478801004131 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 478801004132 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 478801004133 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 478801004134 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 478801004135 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 478801004136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478801004137 homodimer interface [polypeptide binding]; other site 478801004138 catalytic residue [active] 478801004139 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 478801004140 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 478801004141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801004142 hypothetical protein; Provisional; Region: PRK02237 478801004143 glutamate dehydrogenase; Provisional; Region: PRK09414 478801004144 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 478801004145 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 478801004146 NAD(P) binding site [chemical binding]; other site 478801004147 Cation efflux family; Region: Cation_efflux; pfam01545 478801004148 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478801004149 dimerization interface [polypeptide binding]; other site 478801004150 putative DNA binding site [nucleotide binding]; other site 478801004151 putative Zn2+ binding site [ion binding]; other site 478801004152 Uncharacterized conserved protein [Function unknown]; Region: COG2135 478801004153 GtrA-like protein; Region: GtrA; pfam04138 478801004154 Predicted membrane protein [Function unknown]; Region: COG2246 478801004155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801004156 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 478801004157 putative substrate translocation pore; other site 478801004158 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478801004159 Major Facilitator Superfamily; Region: MFS_1; pfam07690 478801004160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801004161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801004162 acyl-CoA esterase; Provisional; Region: PRK10673 478801004163 PGAP1-like protein; Region: PGAP1; pfam07819 478801004164 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 478801004165 catalytic triad [active] 478801004166 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 478801004167 glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091 478801004168 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 478801004169 active site 478801004170 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 478801004171 dimer interface [polypeptide binding]; other site 478801004172 N-terminal domain interface [polypeptide binding]; other site 478801004173 Acyltransferase family; Region: Acyl_transf_3; pfam01757 478801004174 H+ Antiporter protein; Region: 2A0121; TIGR00900 478801004175 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 478801004176 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 478801004177 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 478801004178 threonine synthase; Validated; Region: PRK09225 478801004179 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 478801004180 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478801004181 catalytic residue [active] 478801004182 homoserine kinase; Provisional; Region: PRK01212 478801004183 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 478801004184 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 478801004185 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 478801004186 NAD(P) binding site [chemical binding]; other site 478801004187 catalytic residues [active] 478801004188 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 478801004189 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 478801004190 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 478801004191 active site 478801004192 catalytic tetrad [active] 478801004193 amino acid transporter; Region: 2A0306; TIGR00909 478801004194 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 478801004195 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478801004196 catalytic core [active] 478801004197 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 478801004198 glycine dehydrogenase; Provisional; Region: PRK05367 478801004199 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 478801004200 tetramer interface [polypeptide binding]; other site 478801004201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478801004202 catalytic residue [active] 478801004203 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 478801004204 tetramer interface [polypeptide binding]; other site 478801004205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478801004206 catalytic residue [active] 478801004207 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 478801004208 DNA binding residues [nucleotide binding] 478801004209 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 478801004210 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 478801004211 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 478801004212 DNA binding residues [nucleotide binding] 478801004213 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 478801004214 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 478801004215 phosphopeptide binding site; other site 478801004216 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 478801004217 lipoyl attachment site [posttranslational modification]; other site 478801004218 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 478801004219 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 478801004220 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 478801004221 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 478801004222 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 478801004223 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 478801004224 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 478801004225 Zn binding site [ion binding]; other site 478801004226 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478801004227 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 478801004228 acyl-activating enzyme (AAE) consensus motif; other site 478801004229 AMP binding site [chemical binding]; other site 478801004230 active site 478801004231 CoA binding site [chemical binding]; other site 478801004232 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 478801004233 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 478801004234 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 478801004235 putative trimer interface [polypeptide binding]; other site 478801004236 putative CoA binding site [chemical binding]; other site 478801004237 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 478801004238 putative trimer interface [polypeptide binding]; other site 478801004239 putative CoA binding site [chemical binding]; other site 478801004240 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 478801004241 T5orf172 domain; Region: T5orf172; cl17462 478801004242 Transposase; Region: HTH_Tnp_1; cl17663 478801004243 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478801004244 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 478801004245 Helix-turn-helix domain; Region: HTH_38; pfam13936 478801004246 Homeodomain-like domain; Region: HTH_32; pfam13565 478801004247 Integrase core domain; Region: rve; pfam00665 478801004248 putative transposase OrfB; Reviewed; Region: PHA02517 478801004249 HTH-like domain; Region: HTH_21; pfam13276 478801004250 Integrase core domain; Region: rve; pfam00665 478801004251 Integrase core domain; Region: rve_3; pfam13683 478801004252 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 478801004253 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478801004254 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 478801004255 GTP-binding protein Der; Reviewed; Region: PRK03003 478801004256 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 478801004257 G1 box; other site 478801004258 GTP/Mg2+ binding site [chemical binding]; other site 478801004259 Switch I region; other site 478801004260 G2 box; other site 478801004261 Switch II region; other site 478801004262 G3 box; other site 478801004263 G4 box; other site 478801004264 G5 box; other site 478801004265 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 478801004266 G1 box; other site 478801004267 GTP/Mg2+ binding site [chemical binding]; other site 478801004268 Switch I region; other site 478801004269 G2 box; other site 478801004270 G3 box; other site 478801004271 Switch II region; other site 478801004272 G4 box; other site 478801004273 G5 box; other site 478801004274 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801004275 cytidylate kinase; Provisional; Region: cmk; PRK00023 478801004276 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 478801004277 Walker A/P-loop; other site 478801004278 ATP binding site [chemical binding]; other site 478801004279 CMP-binding site; other site 478801004280 The sites determining sugar specificity; other site 478801004281 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 478801004282 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 478801004283 RNA binding surface [nucleotide binding]; other site 478801004284 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 478801004285 active site 478801004286 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 478801004287 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 478801004288 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 478801004289 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 478801004290 P-loop; other site 478801004291 Magnesium ion binding site [ion binding]; other site 478801004292 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 478801004293 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 478801004294 Magnesium ion binding site [ion binding]; other site 478801004295 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 478801004296 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 478801004297 active site 478801004298 DNA binding site [nucleotide binding] 478801004299 Int/Topo IB signature motif; other site 478801004300 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 478801004301 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 478801004302 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 478801004303 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 478801004304 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 478801004305 active site 478801004306 metal binding site [ion binding]; metal-binding site 478801004307 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 478801004308 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 478801004309 Zn2+ binding site [ion binding]; other site 478801004310 Mg2+ binding site [ion binding]; other site 478801004311 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 478801004312 synthetase active site [active] 478801004313 NTP binding site [chemical binding]; other site 478801004314 metal binding site [ion binding]; metal-binding site 478801004315 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 478801004316 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 478801004317 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 478801004318 active site 478801004319 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 478801004320 Protein export membrane protein; Region: SecD_SecF; pfam02355 478801004321 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 478801004322 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 478801004323 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 478801004324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478801004325 Walker A motif; other site 478801004326 ATP binding site [chemical binding]; other site 478801004327 Walker B motif; other site 478801004328 arginine finger; other site 478801004329 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 478801004330 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 478801004331 RuvA N terminal domain; Region: RuvA_N; pfam01330 478801004332 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 478801004333 active site 478801004334 putative DNA-binding cleft [nucleotide binding]; other site 478801004335 dimer interface [polypeptide binding]; other site 478801004336 hypothetical protein; Validated; Region: PRK00110 478801004337 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 478801004338 predicted active site [active] 478801004339 catalytic triad [active] 478801004340 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 478801004341 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 478801004342 active site 478801004343 multimer interface [polypeptide binding]; other site 478801004344 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 478801004345 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 478801004346 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 478801004347 Predicted membrane protein [Function unknown]; Region: COG2261 478801004348 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 478801004349 nucleotide binding site/active site [active] 478801004350 HIT family signature motif; other site 478801004351 catalytic residue [active] 478801004352 NlpC/P60 family; Region: NLPC_P60; cl17555 478801004353 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 478801004354 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 478801004355 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 478801004356 active site 478801004357 dimer interface [polypeptide binding]; other site 478801004358 motif 1; other site 478801004359 motif 2; other site 478801004360 motif 3; other site 478801004361 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 478801004362 anticodon binding site; other site 478801004363 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 478801004364 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 478801004365 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 478801004366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478801004367 catalytic residue [active] 478801004368 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 478801004369 Protein of unknown function DUF72; Region: DUF72; pfam01904 478801004370 Uncharacterized conserved protein [Function unknown]; Region: COG0397 478801004371 hypothetical protein; Validated; Region: PRK00029 478801004372 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 478801004373 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 478801004374 active site 478801004375 catalytic tetrad [active] 478801004376 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 478801004377 RibD C-terminal domain; Region: RibD_C; cl17279 478801004378 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 478801004379 glycerol kinase; Provisional; Region: glpK; PRK00047 478801004380 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 478801004381 N- and C-terminal domain interface [polypeptide binding]; other site 478801004382 active site 478801004383 MgATP binding site [chemical binding]; other site 478801004384 catalytic site [active] 478801004385 metal binding site [ion binding]; metal-binding site 478801004386 putative homotetramer interface [polypeptide binding]; other site 478801004387 glycerol binding site [chemical binding]; other site 478801004388 homodimer interface [polypeptide binding]; other site 478801004389 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 478801004390 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 478801004391 active site 478801004392 DNA binding site [nucleotide binding] 478801004393 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 478801004394 DNA binding site [nucleotide binding] 478801004395 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 478801004396 nucleotide binding site [chemical binding]; other site 478801004397 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 478801004398 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 478801004399 generic binding surface I; other site 478801004400 generic binding surface II; other site 478801004401 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 478801004402 putative catalytic site [active] 478801004403 putative metal binding site [ion binding]; other site 478801004404 putative phosphate binding site [ion binding]; other site 478801004405 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 478801004406 SelR domain; Region: SelR; pfam01641 478801004407 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 478801004408 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 478801004409 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 478801004410 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 478801004411 substrate binding site [chemical binding]; other site 478801004412 active site 478801004413 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 478801004414 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 478801004415 catalytic site [active] 478801004416 putative active site [active] 478801004417 putative substrate binding site [chemical binding]; other site 478801004418 HRDC domain; Region: HRDC; pfam00570 478801004419 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 478801004420 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 478801004421 non-specific DNA binding site [nucleotide binding]; other site 478801004422 salt bridge; other site 478801004423 sequence-specific DNA binding site [nucleotide binding]; other site 478801004424 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 478801004425 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 478801004426 putative active site [active] 478801004427 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 478801004428 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 478801004429 active site 478801004430 catalytic site [active] 478801004431 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 478801004432 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 478801004433 TPP-binding site; other site 478801004434 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 478801004435 PYR/PP interface [polypeptide binding]; other site 478801004436 dimer interface [polypeptide binding]; other site 478801004437 TPP binding site [chemical binding]; other site 478801004438 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 478801004439 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 478801004440 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 478801004441 active site 478801004442 catalytic triad [active] 478801004443 oxyanion hole [active] 478801004444 aconitate hydratase; Validated; Region: PRK09277 478801004445 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 478801004446 substrate binding site [chemical binding]; other site 478801004447 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 478801004448 ligand binding site [chemical binding]; other site 478801004449 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 478801004450 substrate binding site [chemical binding]; other site 478801004451 TRAM domain; Region: TRAM; pfam01938 478801004452 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 478801004453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478801004454 S-adenosylmethionine binding site [chemical binding]; other site 478801004455 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 478801004456 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 478801004457 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 478801004458 trimer interface [polypeptide binding]; other site 478801004459 active site 478801004460 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 478801004461 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 478801004462 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 478801004463 active site 478801004464 dimerization interface [polypeptide binding]; other site 478801004465 ferrochelatase; Reviewed; Region: hemH; PRK00035 478801004466 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 478801004467 active site 478801004468 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 478801004469 active site 478801004470 N-terminal domain interface [polypeptide binding]; other site 478801004471 Predicted membrane protein [Function unknown]; Region: COG2860 478801004472 UPF0126 domain; Region: UPF0126; pfam03458 478801004473 UPF0126 domain; Region: UPF0126; pfam03458 478801004474 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 478801004475 thymidine kinase; Provisional; Region: PRK04296 478801004476 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 478801004477 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 478801004478 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 478801004479 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 478801004480 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 478801004481 CoA binding domain; Region: CoA_binding_2; pfam13380 478801004482 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 478801004483 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 478801004484 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 478801004485 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478801004486 acyl-activating enzyme (AAE) consensus motif; other site 478801004487 AMP binding site [chemical binding]; other site 478801004488 active site 478801004489 CoA binding site [chemical binding]; other site 478801004490 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 478801004491 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 478801004492 CAP-like domain; other site 478801004493 active site 478801004494 primary dimer interface [polypeptide binding]; other site 478801004495 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 478801004496 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 478801004497 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 478801004498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801004499 Walker A/P-loop; other site 478801004500 ATP binding site [chemical binding]; other site 478801004501 Q-loop/lid; other site 478801004502 ABC transporter signature motif; other site 478801004503 Walker B; other site 478801004504 D-loop; other site 478801004505 H-loop/switch region; other site 478801004506 SdpI/YhfL protein family; Region: SdpI; pfam13630 478801004507 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 478801004508 Staphylococcal nuclease homologues; Region: SNc; smart00318 478801004509 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 478801004510 Catalytic site; other site 478801004511 amino acid transporter; Region: 2A0306; TIGR00909 478801004512 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 478801004513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478801004514 ATP binding site [chemical binding]; other site 478801004515 Mg2+ binding site [ion binding]; other site 478801004516 G-X-G motif; other site 478801004517 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 478801004518 anchoring element; other site 478801004519 dimer interface [polypeptide binding]; other site 478801004520 ATP binding site [chemical binding]; other site 478801004521 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 478801004522 active site 478801004523 metal binding site [ion binding]; metal-binding site 478801004524 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 478801004525 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 478801004526 active site 478801004527 DNA polymerase IV; Validated; Region: PRK02406 478801004528 DNA binding site [nucleotide binding] 478801004529 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 478801004530 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 478801004531 active site 478801004532 PHP Thumb interface [polypeptide binding]; other site 478801004533 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 478801004534 generic binding surface II; other site 478801004535 generic binding surface I; other site 478801004536 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 478801004537 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 478801004538 substrate binding pocket [chemical binding]; other site 478801004539 chain length determination region; other site 478801004540 substrate-Mg2+ binding site; other site 478801004541 catalytic residues [active] 478801004542 aspartate-rich region 1; other site 478801004543 active site lid residues [active] 478801004544 aspartate-rich region 2; other site 478801004545 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 478801004546 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 478801004547 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 478801004548 putative acyl-acceptor binding pocket; other site 478801004549 Esterase/lipase [General function prediction only]; Region: COG1647 478801004550 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 478801004551 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 478801004552 nucleotide binding site [chemical binding]; other site 478801004553 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 478801004554 hypothetical protein; Validated; Region: PRK07883 478801004555 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 478801004556 active site 478801004557 catalytic site [active] 478801004558 substrate binding site [chemical binding]; other site 478801004559 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 478801004560 GIY-YIG motif/motif A; other site 478801004561 active site 478801004562 catalytic site [active] 478801004563 putative DNA binding site [nucleotide binding]; other site 478801004564 metal binding site [ion binding]; metal-binding site 478801004565 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 478801004566 AsnC family; Region: AsnC_trans_reg; pfam01037 478801004567 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 478801004568 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 478801004569 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 478801004570 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 478801004571 Subunit I/III interface [polypeptide binding]; other site 478801004572 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 478801004573 Cytochrome c; Region: Cytochrom_C; pfam00034 478801004574 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 478801004575 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 478801004576 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 478801004577 iron-sulfur cluster [ion binding]; other site 478801004578 [2Fe-2S] cluster binding site [ion binding]; other site 478801004579 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 478801004580 heme bH binding site [chemical binding]; other site 478801004581 Qi binding site; other site 478801004582 intrachain domain interface; other site 478801004583 heme bL binding site [chemical binding]; other site 478801004584 interchain domain interface [polypeptide binding]; other site 478801004585 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 478801004586 Qo binding site; other site 478801004587 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 478801004588 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 478801004589 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 478801004590 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 478801004591 D-pathway; other site 478801004592 Putative ubiquinol binding site [chemical binding]; other site 478801004593 Low-spin heme (heme b) binding site [chemical binding]; other site 478801004594 Putative water exit pathway; other site 478801004595 Binuclear center (heme o3/CuB) [ion binding]; other site 478801004596 K-pathway; other site 478801004597 Putative proton exit pathway; other site 478801004598 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 478801004599 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 478801004600 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 478801004601 Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl17317 478801004602 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 478801004603 hypothetical protein; Provisional; Region: PRK07907 478801004604 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 478801004605 active site 478801004606 metal binding site [ion binding]; metal-binding site 478801004607 dimer interface [polypeptide binding]; other site 478801004608 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 478801004609 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 478801004610 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 478801004611 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 478801004612 multifunctional aminopeptidase A; Provisional; Region: PRK00913 478801004613 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 478801004614 interface (dimer of trimers) [polypeptide binding]; other site 478801004615 Substrate-binding/catalytic site; other site 478801004616 Zn-binding sites [ion binding]; other site 478801004617 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 478801004618 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478801004619 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 478801004620 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 478801004621 E3 interaction surface; other site 478801004622 lipoyl attachment site [posttranslational modification]; other site 478801004623 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 478801004624 E3 interaction surface; other site 478801004625 lipoyl attachment site [posttranslational modification]; other site 478801004626 e3 binding domain; Region: E3_binding; pfam02817 478801004627 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 478801004628 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 478801004629 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 478801004630 lipoyl synthase; Provisional; Region: PRK05481 478801004631 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478801004632 FeS/SAM binding site; other site 478801004633 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 478801004634 RDD family; Region: RDD; pfam06271 478801004635 glutamine synthetase, type I; Region: GlnA; TIGR00653 478801004636 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 478801004637 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 478801004638 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 478801004639 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 478801004640 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 478801004641 Cupin domain; Region: Cupin_2; cl17218 478801004642 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 478801004643 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 478801004644 active site 478801004645 PHP Thumb interface [polypeptide binding]; other site 478801004646 metal binding site [ion binding]; metal-binding site 478801004647 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 478801004648 generic binding surface II; other site 478801004649 generic binding surface I; other site 478801004650 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 478801004651 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 478801004652 active site 478801004653 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 478801004654 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 478801004655 DivIVA protein; Region: DivIVA; pfam05103 478801004656 DivIVA domain; Region: DivI1A_domain; TIGR03544 478801004657 YGGT family; Region: YGGT; cl00508 478801004658 Protein of unknown function (DUF552); Region: DUF552; cl00775 478801004659 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 478801004660 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 478801004661 catalytic residue [active] 478801004662 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 478801004663 cell division protein FtsZ; Validated; Region: PRK09330 478801004664 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 478801004665 nucleotide binding site [chemical binding]; other site 478801004666 SulA interaction site; other site 478801004667 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 478801004668 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 478801004669 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 478801004670 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 478801004671 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 478801004672 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 478801004673 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 478801004674 active site 478801004675 homodimer interface [polypeptide binding]; other site 478801004676 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 478801004677 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 478801004678 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 478801004679 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 478801004680 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 478801004681 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 478801004682 Mg++ binding site [ion binding]; other site 478801004683 putative catalytic motif [active] 478801004684 putative substrate binding site [chemical binding]; other site 478801004685 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 478801004686 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 478801004687 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 478801004688 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 478801004689 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 478801004690 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 478801004691 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 478801004692 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 478801004693 MraW methylase family; Region: Methyltransf_5; cl17771 478801004694 cell division protein MraZ; Reviewed; Region: PRK00326 478801004695 MraZ protein; Region: MraZ; pfam02381 478801004696 MraZ protein; Region: MraZ; pfam02381 478801004697 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 478801004698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478801004699 ATP binding site [chemical binding]; other site 478801004700 Walker A motif; other site 478801004701 Walker B motif; other site 478801004702 arginine finger; other site 478801004703 Protein of unknown function DUF58; Region: DUF58; pfam01882 478801004704 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 478801004705 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 478801004706 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 478801004707 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 478801004708 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478801004709 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 478801004710 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478801004711 DNA binding residues [nucleotide binding] 478801004712 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478801004713 Ligand Binding Site [chemical binding]; other site 478801004714 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 478801004715 PAC2 family; Region: PAC2; pfam09754 478801004716 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 478801004717 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478801004718 ATP binding site [chemical binding]; other site 478801004719 putative Mg++ binding site [ion binding]; other site 478801004720 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478801004721 nucleotide binding region [chemical binding]; other site 478801004722 ATP-binding site [chemical binding]; other site 478801004723 Helicase associated domain (HA2); Region: HA2; pfam04408 478801004724 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 478801004725 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 478801004726 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 478801004727 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 478801004728 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 478801004729 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 478801004730 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 478801004731 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 478801004732 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 478801004733 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 478801004734 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 478801004735 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 478801004736 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 478801004737 Protein of unknown function (DUF445); Region: DUF445; pfam04286 478801004738 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478801004739 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 478801004740 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 478801004741 acyl-activating enzyme (AAE) consensus motif; other site 478801004742 acyl-activating enzyme (AAE) consensus motif; other site 478801004743 putative AMP binding site [chemical binding]; other site 478801004744 putative active site [active] 478801004745 putative CoA binding site [chemical binding]; other site 478801004746 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 478801004747 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 478801004748 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 478801004749 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 478801004750 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 478801004751 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 478801004752 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 478801004753 dimerization domain swap beta strand [polypeptide binding]; other site 478801004754 regulatory protein interface [polypeptide binding]; other site 478801004755 active site 478801004756 regulatory phosphorylation site [posttranslational modification]; other site 478801004757 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 478801004758 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 478801004759 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 478801004760 active site 478801004761 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 478801004762 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 478801004763 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 478801004764 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 478801004765 dimer interface [polypeptide binding]; other site 478801004766 active site 478801004767 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 478801004768 dimer interface [polypeptide binding]; other site 478801004769 active site 478801004770 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 478801004771 active site turn [active] 478801004772 phosphorylation site [posttranslational modification] 478801004773 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 478801004774 HPr interaction site; other site 478801004775 glycerol kinase (GK) interaction site [polypeptide binding]; other site 478801004776 active site 478801004777 phosphorylation site [posttranslational modification] 478801004778 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 478801004779 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 478801004780 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 478801004781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478801004782 dimer interface [polypeptide binding]; other site 478801004783 conserved gate region; other site 478801004784 ABC-ATPase subunit interface; other site 478801004785 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 478801004786 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 478801004787 Walker A/P-loop; other site 478801004788 ATP binding site [chemical binding]; other site 478801004789 Q-loop/lid; other site 478801004790 ABC transporter signature motif; other site 478801004791 Walker B; other site 478801004792 D-loop; other site 478801004793 H-loop/switch region; other site 478801004794 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 478801004795 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 478801004796 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 478801004797 active site 478801004798 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 478801004799 PLD-like domain; Region: PLDc_2; pfam13091 478801004800 putative homodimer interface [polypeptide binding]; other site 478801004801 putative active site [active] 478801004802 catalytic site [active] 478801004803 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 478801004804 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 478801004805 putative Mg++ binding site [ion binding]; other site 478801004806 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478801004807 nucleotide binding region [chemical binding]; other site 478801004808 ATP-binding site [chemical binding]; other site 478801004809 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 478801004810 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 478801004811 DNA-binding interface [nucleotide binding]; DNA binding site 478801004812 putative transposase OrfB; Reviewed; Region: PHA02517 478801004813 HTH-like domain; Region: HTH_21; pfam13276 478801004814 Integrase core domain; Region: rve; pfam00665 478801004815 Integrase core domain; Region: rve_3; pfam13683 478801004816 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 478801004817 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478801004818 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 478801004819 active site 478801004820 Predicted membrane protein [Function unknown]; Region: COG4270 478801004821 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 478801004822 Prostaglandin dehydrogenases; Region: PGDH; cd05288 478801004823 NAD(P) binding site [chemical binding]; other site 478801004824 substrate binding site [chemical binding]; other site 478801004825 dimer interface [polypeptide binding]; other site 478801004826 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 478801004827 Histidine kinase; Region: HisKA_3; pfam07730 478801004828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478801004829 ATP binding site [chemical binding]; other site 478801004830 Mg2+ binding site [ion binding]; other site 478801004831 G-X-G motif; other site 478801004832 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 478801004833 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 478801004834 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 478801004835 active site 478801004836 dimer interface [polypeptide binding]; other site 478801004837 effector binding site; other site 478801004838 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 478801004839 TSCPD domain; Region: TSCPD; pfam12637 478801004840 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 478801004841 ATP cone domain; Region: ATP-cone; pfam03477 478801004842 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 478801004843 Cutinase; Region: Cutinase; pfam01083 478801004844 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 478801004845 LexA repressor; Validated; Region: PRK00215 478801004846 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 478801004847 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 478801004848 Catalytic site [active] 478801004849 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 478801004850 Patatin-like phospholipase; Region: Patatin; pfam01734 478801004851 active site 478801004852 nucleophile elbow; other site 478801004853 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 478801004854 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 478801004855 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478801004856 catalytic residue [active] 478801004857 Transcriptional regulator [Transcription]; Region: LysR; COG0583 478801004858 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 478801004859 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 478801004860 putative dimerization interface [polypeptide binding]; other site 478801004861 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 478801004862 Competence protein; Region: Competence; pfam03772 478801004863 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 478801004864 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 478801004865 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 478801004866 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 478801004867 EDD domain protein, DegV family; Region: DegV; TIGR00762 478801004868 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 478801004869 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 478801004870 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 478801004871 active site 478801004872 HIGH motif; other site 478801004873 nucleotide binding site [chemical binding]; other site 478801004874 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 478801004875 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 478801004876 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 478801004877 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 478801004878 active site 478801004879 KMSKS motif; other site 478801004880 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 478801004881 tRNA binding surface [nucleotide binding]; other site 478801004882 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 478801004883 putative active site [active] 478801004884 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 478801004885 hypothetical protein; Reviewed; Region: PRK07914 478801004886 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 478801004887 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 478801004888 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 478801004889 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 478801004890 putative Mg++ binding site [ion binding]; other site 478801004891 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 478801004892 alpha-glucosidase; Provisional; Region: PRK10137 478801004893 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 478801004894 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 478801004895 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 478801004896 Walker A/P-loop; other site 478801004897 ATP binding site [chemical binding]; other site 478801004898 Q-loop/lid; other site 478801004899 ABC transporter signature motif; other site 478801004900 Walker B; other site 478801004901 D-loop; other site 478801004902 H-loop/switch region; other site 478801004903 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801004904 Walker A/P-loop; other site 478801004905 ATP binding site [chemical binding]; other site 478801004906 ABC transporter; Region: ABC_tran; pfam00005 478801004907 Q-loop/lid; other site 478801004908 ABC transporter signature motif; other site 478801004909 Walker B; other site 478801004910 D-loop; other site 478801004911 H-loop/switch region; other site 478801004912 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 478801004913 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 478801004914 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 478801004915 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 478801004916 HflX GTPase family; Region: HflX; cd01878 478801004917 G1 box; other site 478801004918 GTP/Mg2+ binding site [chemical binding]; other site 478801004919 Switch I region; other site 478801004920 G2 box; other site 478801004921 G3 box; other site 478801004922 Switch II region; other site 478801004923 G4 box; other site 478801004924 G5 box; other site 478801004925 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 478801004926 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 478801004927 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 478801004928 putative active site [active] 478801004929 putative metal binding site [ion binding]; other site 478801004930 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 478801004931 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 478801004932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478801004933 S-adenosylmethionine binding site [chemical binding]; other site 478801004934 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478801004935 Coenzyme A binding pocket [chemical binding]; other site 478801004936 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 478801004937 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 478801004938 PEP synthetase regulatory protein; Provisional; Region: PRK05339 478801004939 pyruvate phosphate dikinase; Provisional; Region: PRK09279 478801004940 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 478801004941 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 478801004942 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 478801004943 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 478801004944 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 478801004945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478801004946 active site 478801004947 phosphorylation site [posttranslational modification] 478801004948 intermolecular recognition site; other site 478801004949 dimerization interface [polypeptide binding]; other site 478801004950 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 478801004951 DNA binding residues [nucleotide binding] 478801004952 dimerization interface [polypeptide binding]; other site 478801004953 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 478801004954 Histidine kinase; Region: HisKA_3; pfam07730 478801004955 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 478801004956 FtsX-like permease family; Region: FtsX; pfam02687 478801004957 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 478801004958 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 478801004959 Walker A/P-loop; other site 478801004960 ATP binding site [chemical binding]; other site 478801004961 Q-loop/lid; other site 478801004962 ABC transporter signature motif; other site 478801004963 Walker B; other site 478801004964 D-loop; other site 478801004965 H-loop/switch region; other site 478801004966 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478801004967 MULE transposase domain; Region: MULE; pfam10551 478801004968 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478801004969 dimerization interface [polypeptide binding]; other site 478801004970 putative Zn2+ binding site [ion binding]; other site 478801004971 putative DNA binding site [nucleotide binding]; other site 478801004972 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 478801004973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801004974 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 478801004975 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 478801004976 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478801004977 FeS/SAM binding site; other site 478801004978 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 478801004979 recombination regulator RecX; Reviewed; Region: recX; PRK00117 478801004980 recombinase A; Provisional; Region: recA; PRK09354 478801004981 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 478801004982 hexamer interface [polypeptide binding]; other site 478801004983 Walker A motif; other site 478801004984 ATP binding site [chemical binding]; other site 478801004985 Walker B motif; other site 478801004986 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 478801004987 Membrane transport protein; Region: Mem_trans; cl09117 478801004988 DEAD-like helicases superfamily; Region: DEXDc; smart00487 478801004989 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478801004990 ATP binding site [chemical binding]; other site 478801004991 putative Mg++ binding site [ion binding]; other site 478801004992 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 478801004993 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478801004994 nucleotide binding region [chemical binding]; other site 478801004995 ATP-binding site [chemical binding]; other site 478801004996 DEAD/H associated; Region: DEAD_assoc; pfam08494 478801004997 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 478801004998 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 478801004999 putative DNA binding site [nucleotide binding]; other site 478801005000 catalytic residue [active] 478801005001 putative H2TH interface [polypeptide binding]; other site 478801005002 putative catalytic residues [active] 478801005003 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 478801005004 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 478801005005 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 478801005006 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478801005007 metal binding site [ion binding]; metal-binding site 478801005008 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478801005009 Transposase; Region: HTH_Tnp_1; pfam01527 478801005010 Transposase; Region: HTH_Tnp_1; cl17663 478801005011 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 478801005012 Helix-turn-helix domain; Region: HTH_38; pfam13936 478801005013 Integrase core domain; Region: rve; pfam00665 478801005014 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 478801005015 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 478801005016 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 478801005017 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478801005018 Coenzyme A binding pocket [chemical binding]; other site 478801005019 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478801005020 Ribosomal RNA adenine dimethylases; Region: rADc; smart00650 478801005021 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 478801005022 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 478801005023 Predicted transcriptional regulators [Transcription]; Region: COG1733 478801005024 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 478801005025 Transposase; Region: HTH_Tnp_1; cl17663 478801005026 Predicted transcriptional regulator [Transcription]; Region: COG2378 478801005027 HTH domain; Region: HTH_11; pfam08279 478801005028 WYL domain; Region: WYL; pfam13280 478801005029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478801005030 NADH(P)-binding; Region: NAD_binding_10; pfam13460 478801005031 NAD(P) binding site [chemical binding]; other site 478801005032 active site 478801005033 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478801005034 MULE transposase domain; Region: MULE; pfam10551 478801005035 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 478801005036 Integrase core domain; Region: rve; pfam00665 478801005037 Integrase core domain; Region: rve_3; pfam13683 478801005038 Integrase core domain; Region: rve; pfam00665 478801005039 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 478801005040 Integrase core domain; Region: rve_3; pfam13683 478801005041 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 478801005042 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 478801005043 non-specific DNA binding site [nucleotide binding]; other site 478801005044 salt bridge; other site 478801005045 sequence-specific DNA binding site [nucleotide binding]; other site 478801005046 Competence-damaged protein; Region: CinA; pfam02464 478801005047 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 478801005048 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 478801005049 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 478801005050 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478801005051 FeS/SAM binding site; other site 478801005052 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478801005053 MULE transposase domain; Region: MULE; pfam10551 478801005054 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478801005055 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478801005056 active site 478801005057 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 478801005058 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 478801005059 active site 478801005060 dimer interface [polypeptide binding]; other site 478801005061 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 478801005062 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 478801005063 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 478801005064 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 478801005065 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 478801005066 putative DNA binding site [nucleotide binding]; other site 478801005067 putative Zn2+ binding site [ion binding]; other site 478801005068 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 478801005069 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 478801005070 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 478801005071 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 478801005072 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 478801005073 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 478801005074 hypothetical protein; Provisional; Region: PRK03298 478801005075 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 478801005076 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 478801005077 gamma subunit interface [polypeptide binding]; other site 478801005078 LBP interface [polypeptide binding]; other site 478801005079 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 478801005080 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 478801005081 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 478801005082 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 478801005083 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 478801005084 alpha subunit interaction interface [polypeptide binding]; other site 478801005085 Walker A motif; other site 478801005086 ATP binding site [chemical binding]; other site 478801005087 Walker B motif; other site 478801005088 inhibitor binding site; inhibition site 478801005089 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 478801005090 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 478801005091 core domain interface [polypeptide binding]; other site 478801005092 delta subunit interface [polypeptide binding]; other site 478801005093 epsilon subunit interface [polypeptide binding]; other site 478801005094 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 478801005095 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 478801005096 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 478801005097 beta subunit interaction interface [polypeptide binding]; other site 478801005098 Walker A motif; other site 478801005099 ATP binding site [chemical binding]; other site 478801005100 Walker B motif; other site 478801005101 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 478801005102 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 478801005103 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 478801005104 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 478801005105 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 478801005106 ATP synthase subunit C; Region: ATP-synt_C; cl00466 478801005107 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 478801005108 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 478801005109 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 478801005110 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 478801005111 Mg++ binding site [ion binding]; other site 478801005112 putative catalytic motif [active] 478801005113 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 478801005114 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 478801005115 dimer interface [polypeptide binding]; other site 478801005116 active site 478801005117 glycine-pyridoxal phosphate binding site [chemical binding]; other site 478801005118 folate binding site [chemical binding]; other site 478801005119 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 478801005120 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 478801005121 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 478801005122 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 478801005123 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 478801005124 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 478801005125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478801005126 S-adenosylmethionine binding site [chemical binding]; other site 478801005127 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 478801005128 PCRF domain; Region: PCRF; pfam03462 478801005129 RF-1 domain; Region: RF-1; pfam00472 478801005130 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 478801005131 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 478801005132 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 478801005133 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 478801005134 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 478801005135 transcription termination factor Rho; Provisional; Region: PRK12608 478801005136 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 478801005137 RNA binding site [nucleotide binding]; other site 478801005138 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 478801005139 multimer interface [polypeptide binding]; other site 478801005140 Walker A motif; other site 478801005141 ATP binding site [chemical binding]; other site 478801005142 Walker B motif; other site 478801005143 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 478801005144 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 478801005145 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 478801005146 active site 478801005147 HIGH motif; other site 478801005148 KMSK motif region; other site 478801005149 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 478801005150 tRNA binding surface [nucleotide binding]; other site 478801005151 anticodon binding site; other site 478801005152 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 478801005153 putative active site [active] 478801005154 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 478801005155 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 478801005156 Walker A/P-loop; other site 478801005157 ATP binding site [chemical binding]; other site 478801005158 Q-loop/lid; other site 478801005159 ABC transporter signature motif; other site 478801005160 Walker B; other site 478801005161 D-loop; other site 478801005162 H-loop/switch region; other site 478801005163 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 478801005164 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 478801005165 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 478801005166 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 478801005167 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 478801005168 TPP-binding site [chemical binding]; other site 478801005169 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 478801005170 dimer interface [polypeptide binding]; other site 478801005171 PYR/PP interface [polypeptide binding]; other site 478801005172 TPP binding site [chemical binding]; other site 478801005173 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 478801005174 active site 478801005175 catalytic triad [active] 478801005176 oxyanion hole [active] 478801005177 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 478801005178 Catalytic site [active] 478801005179 Cupin domain; Region: Cupin_2; cl17218 478801005180 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 478801005181 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 478801005182 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 478801005183 NAD(P) binding site [chemical binding]; other site 478801005184 homodimer interface [polypeptide binding]; other site 478801005185 substrate binding site [chemical binding]; other site 478801005186 active site 478801005187 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 478801005188 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 478801005189 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 478801005190 active site 478801005191 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 478801005192 Zn2+ binding site [ion binding]; other site 478801005193 Mg2+ binding site [ion binding]; other site 478801005194 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 478801005195 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 478801005196 Zn2+ binding site [ion binding]; other site 478801005197 Mg2+ binding site [ion binding]; other site 478801005198 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 478801005199 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 478801005200 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 478801005201 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478801005202 DNA binding residues [nucleotide binding] 478801005203 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 478801005204 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 478801005205 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 478801005206 putative catalytic motif [active] 478801005207 putative substrate binding site [chemical binding]; other site 478801005208 putative glycosyl transferase; Provisional; Region: PRK10307 478801005209 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 478801005210 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 478801005211 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478801005212 NAD(P) binding site [chemical binding]; other site 478801005213 active site 478801005214 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 478801005215 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 478801005216 NAD(P) binding site [chemical binding]; other site 478801005217 homodimer interface [polypeptide binding]; other site 478801005218 substrate binding site [chemical binding]; other site 478801005219 active site 478801005220 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 478801005221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478801005222 NAD(P) binding site [chemical binding]; other site 478801005223 active site 478801005224 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 478801005225 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 478801005226 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 478801005227 active site 478801005228 homodimer interface [polypeptide binding]; other site 478801005229 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 478801005230 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 478801005231 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 478801005232 putative active site [active] 478801005233 putative metal binding site [ion binding]; other site 478801005234 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 478801005235 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 478801005236 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 478801005237 trimer interface [polypeptide binding]; other site 478801005238 active site 478801005239 substrate binding site [chemical binding]; other site 478801005240 CoA binding site [chemical binding]; other site 478801005241 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 478801005242 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478801005243 Transposase; Region: HTH_Tnp_1; pfam01527 478801005244 putative transposase OrfB; Reviewed; Region: PHA02517 478801005245 Integrase core domain; Region: rve; pfam00665 478801005246 Integrase core domain; Region: rve_2; pfam13333 478801005247 Right handed beta helix region; Region: Beta_helix; pfam13229 478801005248 Right handed beta helix region; Region: Beta_helix; pfam13229 478801005249 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 478801005250 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 478801005251 CysD dimerization site [polypeptide binding]; other site 478801005252 G1 box; other site 478801005253 putative GEF interaction site [polypeptide binding]; other site 478801005254 GTP/Mg2+ binding site [chemical binding]; other site 478801005255 Switch I region; other site 478801005256 G2 box; other site 478801005257 G3 box; other site 478801005258 Switch II region; other site 478801005259 G4 box; other site 478801005260 G5 box; other site 478801005261 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 478801005262 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 478801005263 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 478801005264 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 478801005265 Active Sites [active] 478801005266 Putative capsular polysaccharide synthesis protein; Region: NKWYS; pfam10364 478801005267 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 478801005268 ligand-binding site [chemical binding]; other site 478801005269 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 478801005270 Uncharacterized conserved protein [Function unknown]; Region: COG2135 478801005271 Predicted membrane protein [Function unknown]; Region: COG2259 478801005272 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 478801005273 putative active site [active] 478801005274 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 478801005275 UDP-glucose 4-epimerase; Region: PLN02240 478801005276 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 478801005277 NAD binding site [chemical binding]; other site 478801005278 homodimer interface [polypeptide binding]; other site 478801005279 active site 478801005280 substrate binding site [chemical binding]; other site 478801005281 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 478801005282 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 478801005283 Spherulation-specific family 4; Region: Spherulin4; pfam12138 478801005284 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 478801005285 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 478801005286 Predicted membrane protein [Function unknown]; Region: COG2259 478801005287 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 478801005288 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 478801005289 hinge; other site 478801005290 active site 478801005291 Predicted GTPases [General function prediction only]; Region: COG1162 478801005292 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 478801005293 GTPase/Zn-binding domain interface [polypeptide binding]; other site 478801005294 GTP/Mg2+ binding site [chemical binding]; other site 478801005295 G4 box; other site 478801005296 G5 box; other site 478801005297 G1 box; other site 478801005298 Switch I region; other site 478801005299 G2 box; other site 478801005300 G3 box; other site 478801005301 Switch II region; other site 478801005302 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 478801005303 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 478801005304 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 478801005305 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 478801005306 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 478801005307 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 478801005308 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478801005309 Uncharacterized conserved protein [Function unknown]; Region: COG1615 478801005310 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 478801005311 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 478801005312 protein binding site [polypeptide binding]; other site 478801005313 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 478801005314 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 478801005315 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 478801005316 Protein of unknown function DUF45; Region: DUF45; cl00636 478801005317 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478801005318 enoyl-CoA hydratase; Provisional; Region: PRK06688 478801005319 substrate binding site [chemical binding]; other site 478801005320 oxyanion hole (OAH) forming residues; other site 478801005321 trimer interface [polypeptide binding]; other site 478801005322 Transcription factor WhiB; Region: Whib; pfam02467 478801005323 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 478801005324 Part of AAA domain; Region: AAA_19; pfam13245 478801005325 Family description; Region: UvrD_C_2; pfam13538 478801005326 HRDC domain; Region: HRDC; pfam00570 478801005327 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 478801005328 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 478801005329 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 478801005330 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 478801005331 putative NADH binding site [chemical binding]; other site 478801005332 putative active site [active] 478801005333 nudix motif; other site 478801005334 putative metal binding site [ion binding]; other site 478801005335 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 478801005336 Phosphotransferase enzyme family; Region: APH; pfam01636 478801005337 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 478801005338 substrate binding site [chemical binding]; other site 478801005339 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 478801005340 Family description; Region: UvrD_C_2; pfam13538 478801005341 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 478801005342 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 478801005343 ATP binding site [chemical binding]; other site 478801005344 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 478801005345 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 478801005346 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 478801005347 ATP binding site [chemical binding]; other site 478801005348 substrate interface [chemical binding]; other site 478801005349 MoeZ/MoeB domain; Region: MoeZ_MoeB; pfam05237 478801005350 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 478801005351 active site residue [active] 478801005352 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 478801005353 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 478801005354 DEAD-like helicases superfamily; Region: DEXDc; smart00487 478801005355 ATP binding site [chemical binding]; other site 478801005356 Mg++ binding site [ion binding]; other site 478801005357 motif III; other site 478801005358 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478801005359 nucleotide binding region [chemical binding]; other site 478801005360 ATP-binding site [chemical binding]; other site 478801005361 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 478801005362 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 478801005363 active site 478801005364 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 478801005365 Uncharacterized conserved protein [Function unknown]; Region: COG2966 478801005366 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 478801005367 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 478801005368 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 478801005369 proline aminopeptidase P II; Provisional; Region: PRK10879 478801005370 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 478801005371 active site 478801005372 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 478801005373 MPT binding site; other site 478801005374 trimer interface [polypeptide binding]; other site 478801005375 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 478801005376 MoaE homodimer interface [polypeptide binding]; other site 478801005377 MoaD interaction [polypeptide binding]; other site 478801005378 active site residues [active] 478801005379 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 478801005380 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478801005381 FeS/SAM binding site; other site 478801005382 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 478801005383 Ubiquitin-like proteins; Region: UBQ; cl00155 478801005384 charged pocket; other site 478801005385 hydrophobic patch; other site 478801005386 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 478801005387 trimer interface [polypeptide binding]; other site 478801005388 dimer interface [polypeptide binding]; other site 478801005389 putative active site [active] 478801005390 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 478801005391 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 478801005392 dimer interface [polypeptide binding]; other site 478801005393 putative functional site; other site 478801005394 putative MPT binding site; other site 478801005395 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 478801005396 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 478801005397 ATP binding site [chemical binding]; other site 478801005398 substrate interface [chemical binding]; other site 478801005399 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 478801005400 active site residue [active] 478801005401 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 478801005402 MgtE intracellular N domain; Region: MgtE_N; smart00924 478801005403 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 478801005404 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 478801005405 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 478801005406 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 478801005407 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 478801005408 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 478801005409 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 478801005410 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 478801005411 enoyl-CoA hydratase; Provisional; Region: PRK06688 478801005412 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478801005413 substrate binding site [chemical binding]; other site 478801005414 oxyanion hole (OAH) forming residues; other site 478801005415 trimer interface [polypeptide binding]; other site 478801005416 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 478801005417 hydrophobic ligand binding site; other site 478801005418 DivIVA domain; Region: DivI1A_domain; TIGR03544 478801005419 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 478801005420 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 478801005421 dimer interface [polypeptide binding]; other site 478801005422 Citrate synthase; Region: Citrate_synt; pfam00285 478801005423 active site 478801005424 citrylCoA binding site [chemical binding]; other site 478801005425 NADH binding [chemical binding]; other site 478801005426 cationic pore residues; other site 478801005427 oxalacetate/citrate binding site [chemical binding]; other site 478801005428 coenzyme A binding site [chemical binding]; other site 478801005429 catalytic triad [active] 478801005430 Ferredoxin [Energy production and conversion]; Region: COG1146 478801005431 4Fe-4S binding domain; Region: Fer4; pfam00037 478801005432 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 478801005433 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 478801005434 VanW like protein; Region: VanW; pfam04294 478801005435 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 478801005436 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 478801005437 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 478801005438 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 478801005439 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 478801005440 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 478801005441 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 478801005442 G1 box; other site 478801005443 putative GEF interaction site [polypeptide binding]; other site 478801005444 GTP/Mg2+ binding site [chemical binding]; other site 478801005445 Switch I region; other site 478801005446 G2 box; other site 478801005447 G3 box; other site 478801005448 Switch II region; other site 478801005449 G4 box; other site 478801005450 G5 box; other site 478801005451 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 478801005452 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 478801005453 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 478801005454 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 478801005455 peptide binding site [polypeptide binding]; other site 478801005456 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 478801005457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478801005458 dimer interface [polypeptide binding]; other site 478801005459 conserved gate region; other site 478801005460 putative PBP binding loops; other site 478801005461 ABC-ATPase subunit interface; other site 478801005462 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 478801005463 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 478801005464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478801005465 dimer interface [polypeptide binding]; other site 478801005466 conserved gate region; other site 478801005467 putative PBP binding loops; other site 478801005468 ABC-ATPase subunit interface; other site 478801005469 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 478801005470 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 478801005471 Walker A/P-loop; other site 478801005472 ATP binding site [chemical binding]; other site 478801005473 Q-loop/lid; other site 478801005474 ABC transporter signature motif; other site 478801005475 Walker B; other site 478801005476 D-loop; other site 478801005477 H-loop/switch region; other site 478801005478 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 478801005479 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 478801005480 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 478801005481 Walker A/P-loop; other site 478801005482 ATP binding site [chemical binding]; other site 478801005483 Q-loop/lid; other site 478801005484 ABC transporter signature motif; other site 478801005485 Walker B; other site 478801005486 D-loop; other site 478801005487 H-loop/switch region; other site 478801005488 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 478801005489 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 478801005490 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 478801005491 catalytic triad [active] 478801005492 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478801005493 Ligand Binding Site [chemical binding]; other site 478801005494 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 478801005495 Ligand Binding Site [chemical binding]; other site 478801005496 aspartate kinase; Reviewed; Region: PRK06635 478801005497 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 478801005498 putative catalytic residues [active] 478801005499 putative nucleotide binding site [chemical binding]; other site 478801005500 putative aspartate binding site [chemical binding]; other site 478801005501 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 478801005502 putative allosteric regulatory site; other site 478801005503 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 478801005504 putative allosteric regulatory residue; other site 478801005505 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 478801005506 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 478801005507 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 478801005508 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478801005509 Coenzyme A binding pocket [chemical binding]; other site 478801005510 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 478801005511 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 478801005512 inhibitor-cofactor binding pocket; inhibition site 478801005513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478801005514 catalytic residue [active] 478801005515 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 478801005516 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 478801005517 Predicted flavoprotein [General function prediction only]; Region: COG0431 478801005518 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 478801005519 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 478801005520 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 478801005521 ThiC-associated domain; Region: ThiC-associated; pfam13667 478801005522 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 478801005523 ThiC family; Region: ThiC; pfam01964 478801005524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 478801005525 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 478801005526 active site 478801005527 SUMO-1 interface [polypeptide binding]; other site 478801005528 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 478801005529 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 478801005530 classical (c) SDRs; Region: SDR_c; cd05233 478801005531 NAD(P) binding site [chemical binding]; other site 478801005532 active site 478801005533 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 478801005534 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 478801005535 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 478801005536 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 478801005537 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 478801005538 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 478801005539 nucleotide binding site [chemical binding]; other site 478801005540 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 478801005541 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 478801005542 active site 478801005543 DNA binding site [nucleotide binding] 478801005544 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 478801005545 DNA binding site [nucleotide binding] 478801005546 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 478801005547 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 478801005548 putative DNA binding site [nucleotide binding]; other site 478801005549 putative homodimer interface [polypeptide binding]; other site 478801005550 Protein of unknown function (DUF664); Region: DUF664; pfam04978 478801005551 DinB superfamily; Region: DinB_2; pfam12867 478801005552 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 478801005553 Cupin domain; Region: Cupin_2; cl17218 478801005554 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 478801005555 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 478801005556 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478801005557 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 478801005558 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478801005559 motif II; other site 478801005560 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 478801005561 Protein of unknown function DUF86; Region: DUF86; pfam01934 478801005562 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 478801005563 active site 478801005564 NTP binding site [chemical binding]; other site 478801005565 metal binding triad [ion binding]; metal-binding site 478801005566 hypothetical protein; Provisional; Region: PRK02237 478801005567 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 478801005568 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 478801005569 ATP binding site [chemical binding]; other site 478801005570 substrate interface [chemical binding]; other site 478801005571 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 478801005572 MoaE homodimer interface [polypeptide binding]; other site 478801005573 MoaD interaction [polypeptide binding]; other site 478801005574 active site residues [active] 478801005575 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 478801005576 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 478801005577 dimer interface [polypeptide binding]; other site 478801005578 putative functional site; other site 478801005579 putative MPT binding site; other site 478801005580 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 478801005581 trimer interface [polypeptide binding]; other site 478801005582 dimer interface [polypeptide binding]; other site 478801005583 putative active site [active] 478801005584 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 478801005585 MPT binding site; other site 478801005586 trimer interface [polypeptide binding]; other site 478801005587 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 478801005588 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478801005589 FeS/SAM binding site; other site 478801005590 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 478801005591 Ubiquitin-like proteins; Region: UBQ; cl00155 478801005592 charged pocket; other site 478801005593 hydrophobic patch; other site 478801005594 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 478801005595 active site 478801005596 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 478801005597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478801005598 putative PBP binding loops; other site 478801005599 ABC-ATPase subunit interface; other site 478801005600 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 478801005601 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 478801005602 The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918 478801005603 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 478801005604 acyl-activating enzyme (AAE) consensus motif; other site 478801005605 AMP binding site [chemical binding]; other site 478801005606 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 478801005607 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 478801005608 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 478801005609 putative trimer interface [polypeptide binding]; other site 478801005610 putative CoA binding site [chemical binding]; other site 478801005611 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 478801005612 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 478801005613 putative trimer interface [polypeptide binding]; other site 478801005614 putative CoA binding site [chemical binding]; other site 478801005615 Domain of unknown function (DUF368); Region: DUF368; pfam04018 478801005616 hypothetical protein; Provisional; Region: PRK04233 478801005617 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 478801005618 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 478801005619 ligand binding site [chemical binding]; other site 478801005620 flexible hinge region; other site 478801005621 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 478801005622 putative switch regulator; other site 478801005623 non-specific DNA interactions [nucleotide binding]; other site 478801005624 DNA binding site [nucleotide binding] 478801005625 sequence specific DNA binding site [nucleotide binding]; other site 478801005626 putative cAMP binding site [chemical binding]; other site 478801005627 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 478801005628 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 478801005629 metal-binding site [ion binding] 478801005630 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 478801005631 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478801005632 Soluble P-type ATPase [General function prediction only]; Region: COG4087 478801005633 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478801005634 Transposase; Region: HTH_Tnp_1; pfam01527 478801005635 putative transposase OrfB; Reviewed; Region: PHA02517 478801005636 Integrase core domain; Region: rve; pfam00665 478801005637 Integrase core domain; Region: rve_3; cl15866 478801005638 WHG domain; Region: WHG; pfam13305 478801005639 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478801005640 MULE transposase domain; Region: MULE; pfam10551 478801005641 Transposase; Region: DEDD_Tnp_IS110; pfam01548 478801005642 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 478801005643 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 478801005644 GTP-binding protein YchF; Reviewed; Region: PRK09601 478801005645 YchF GTPase; Region: YchF; cd01900 478801005646 G1 box; other site 478801005647 GTP/Mg2+ binding site [chemical binding]; other site 478801005648 Switch I region; other site 478801005649 G2 box; other site 478801005650 Switch II region; other site 478801005651 G3 box; other site 478801005652 G4 box; other site 478801005653 G5 box; other site 478801005654 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 478801005655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801005656 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 478801005657 RmuC family; Region: RmuC; pfam02646 478801005658 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 478801005659 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 478801005660 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 478801005661 DNA binding residues [nucleotide binding] 478801005662 drug binding residues [chemical binding]; other site 478801005663 dimer interface [polypeptide binding]; other site 478801005664 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 478801005665 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 478801005666 catalytic residues [active] 478801005667 Recombinase; Region: Recombinase; pfam07508 478801005668 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 478801005669 Plasmid replication protein; Region: Rep_2; pfam01719 478801005670 RNA helicase; Region: RNA_helicase; pfam00910 478801005671 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478801005672 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 478801005673 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 478801005674 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 478801005675 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 478801005676 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 478801005677 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 478801005678 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 478801005679 generic binding surface II; other site 478801005680 generic binding surface I; other site 478801005681 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 478801005682 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 478801005683 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 478801005684 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 478801005685 putative active site [active] 478801005686 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 478801005687 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 478801005688 putative substrate binding site [chemical binding]; other site 478801005689 putative ATP binding site [chemical binding]; other site 478801005690 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 478801005691 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 478801005692 Walker A/P-loop; other site 478801005693 ATP binding site [chemical binding]; other site 478801005694 Q-loop/lid; other site 478801005695 ABC transporter signature motif; other site 478801005696 Walker B; other site 478801005697 D-loop; other site 478801005698 H-loop/switch region; other site 478801005699 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 478801005700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478801005701 dimer interface [polypeptide binding]; other site 478801005702 conserved gate region; other site 478801005703 putative PBP binding loops; other site 478801005704 ABC-ATPase subunit interface; other site 478801005705 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 478801005706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478801005707 dimer interface [polypeptide binding]; other site 478801005708 conserved gate region; other site 478801005709 putative PBP binding loops; other site 478801005710 ABC-ATPase subunit interface; other site 478801005711 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 478801005712 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 478801005713 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 478801005714 active site clefts [active] 478801005715 zinc binding site [ion binding]; other site 478801005716 dimer interface [polypeptide binding]; other site 478801005717 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 478801005718 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 478801005719 active site 478801005720 substrate binding site [chemical binding]; other site 478801005721 metal binding site [ion binding]; metal-binding site 478801005722 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 478801005723 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 478801005724 23S rRNA interface [nucleotide binding]; other site 478801005725 L3 interface [polypeptide binding]; other site 478801005726 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478801005727 putative DNA binding site [nucleotide binding]; other site 478801005728 dimerization interface [polypeptide binding]; other site 478801005729 putative Zn2+ binding site [ion binding]; other site 478801005730 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 478801005731 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 478801005732 dimerization interface 3.5A [polypeptide binding]; other site 478801005733 active site 478801005734 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 478801005735 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478801005736 motif II; other site 478801005737 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 478801005738 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 478801005739 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 478801005740 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 478801005741 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 478801005742 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 478801005743 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 478801005744 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 478801005745 alphaNTD homodimer interface [polypeptide binding]; other site 478801005746 alphaNTD - beta interaction site [polypeptide binding]; other site 478801005747 alphaNTD - beta' interaction site [polypeptide binding]; other site 478801005748 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 478801005749 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 478801005750 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 478801005751 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 478801005752 RNA binding surface [nucleotide binding]; other site 478801005753 30S ribosomal protein S11; Validated; Region: PRK05309 478801005754 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 478801005755 30S ribosomal protein S13; Region: bact_S13; TIGR03631 478801005756 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 478801005757 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 478801005758 rRNA binding site [nucleotide binding]; other site 478801005759 predicted 30S ribosome binding site; other site 478801005760 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 478801005761 active site 478801005762 adenylate kinase; Reviewed; Region: adk; PRK00279 478801005763 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 478801005764 AMP-binding site [chemical binding]; other site 478801005765 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 478801005766 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 478801005767 SecY translocase; Region: SecY; pfam00344 478801005768 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 478801005769 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 478801005770 23S rRNA binding site [nucleotide binding]; other site 478801005771 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 478801005772 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 478801005773 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 478801005774 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 478801005775 5S rRNA interface [nucleotide binding]; other site 478801005776 L27 interface [polypeptide binding]; other site 478801005777 23S rRNA interface [nucleotide binding]; other site 478801005778 L5 interface [polypeptide binding]; other site 478801005779 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 478801005780 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 478801005781 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 478801005782 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 478801005783 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 478801005784 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 478801005785 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 478801005786 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 478801005787 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 478801005788 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 478801005789 RNA binding site [nucleotide binding]; other site 478801005790 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 478801005791 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 478801005792 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 478801005793 putative translocon interaction site; other site 478801005794 signal recognition particle (SRP54) interaction site; other site 478801005795 L23 interface [polypeptide binding]; other site 478801005796 trigger factor interaction site; other site 478801005797 23S rRNA interface [nucleotide binding]; other site 478801005798 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 478801005799 23S rRNA interface [nucleotide binding]; other site 478801005800 5S rRNA interface [nucleotide binding]; other site 478801005801 putative antibiotic binding site [chemical binding]; other site 478801005802 L25 interface [polypeptide binding]; other site 478801005803 L27 interface [polypeptide binding]; other site 478801005804 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 478801005805 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 478801005806 G-X-X-G motif; other site 478801005807 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 478801005808 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 478801005809 putative translocon binding site; other site 478801005810 protein-rRNA interface [nucleotide binding]; other site 478801005811 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 478801005812 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 478801005813 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 478801005814 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 478801005815 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 478801005816 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 478801005817 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 478801005818 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 478801005819 Protein of unknown function (DUF554); Region: DUF554; cl00784 478801005820 elongation factor Tu; Reviewed; Region: PRK00049 478801005821 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 478801005822 G1 box; other site 478801005823 GEF interaction site [polypeptide binding]; other site 478801005824 GTP/Mg2+ binding site [chemical binding]; other site 478801005825 Switch I region; other site 478801005826 G2 box; other site 478801005827 G3 box; other site 478801005828 Switch II region; other site 478801005829 G4 box; other site 478801005830 G5 box; other site 478801005831 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 478801005832 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 478801005833 Antibiotic Binding Site [chemical binding]; other site 478801005834 elongation factor G; Reviewed; Region: PRK00007 478801005835 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 478801005836 G1 box; other site 478801005837 putative GEF interaction site [polypeptide binding]; other site 478801005838 GTP/Mg2+ binding site [chemical binding]; other site 478801005839 Switch I region; other site 478801005840 G2 box; other site 478801005841 G3 box; other site 478801005842 Switch II region; other site 478801005843 G4 box; other site 478801005844 G5 box; other site 478801005845 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 478801005846 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 478801005847 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 478801005848 30S ribosomal protein S7; Validated; Region: PRK05302 478801005849 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 478801005850 S17 interaction site [polypeptide binding]; other site 478801005851 S8 interaction site; other site 478801005852 16S rRNA interaction site [nucleotide binding]; other site 478801005853 streptomycin interaction site [chemical binding]; other site 478801005854 23S rRNA interaction site [nucleotide binding]; other site 478801005855 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 478801005856 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 478801005857 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 478801005858 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 478801005859 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 478801005860 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 478801005861 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 478801005862 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 478801005863 G-loop; other site 478801005864 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 478801005865 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 478801005866 DNA binding site [nucleotide binding] 478801005867 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 478801005868 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 478801005869 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 478801005870 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 478801005871 RPB10 interaction site [polypeptide binding]; other site 478801005872 RPB1 interaction site [polypeptide binding]; other site 478801005873 RPB11 interaction site [polypeptide binding]; other site 478801005874 RPB3 interaction site [polypeptide binding]; other site 478801005875 RPB12 interaction site [polypeptide binding]; other site 478801005876 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 478801005877 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 478801005878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801005879 Walker A/P-loop; other site 478801005880 ATP binding site [chemical binding]; other site 478801005881 Q-loop/lid; other site 478801005882 ABC transporter signature motif; other site 478801005883 Walker B; other site 478801005884 D-loop; other site 478801005885 H-loop/switch region; other site 478801005886 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 478801005887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801005888 Walker A/P-loop; other site 478801005889 ATP binding site [chemical binding]; other site 478801005890 Q-loop/lid; other site 478801005891 ABC transporter signature motif; other site 478801005892 Walker B; other site 478801005893 D-loop; other site 478801005894 H-loop/switch region; other site 478801005895 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 478801005896 core dimer interface [polypeptide binding]; other site 478801005897 peripheral dimer interface [polypeptide binding]; other site 478801005898 L10 interface [polypeptide binding]; other site 478801005899 L11 interface [polypeptide binding]; other site 478801005900 putative EF-Tu interaction site [polypeptide binding]; other site 478801005901 putative EF-G interaction site [polypeptide binding]; other site 478801005902 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 478801005903 23S rRNA interface [nucleotide binding]; other site 478801005904 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 478801005905 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 478801005906 mRNA/rRNA interface [nucleotide binding]; other site 478801005907 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 478801005908 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 478801005909 23S rRNA interface [nucleotide binding]; other site 478801005910 L7/L12 interface [polypeptide binding]; other site 478801005911 putative thiostrepton binding site; other site 478801005912 L25 interface [polypeptide binding]; other site 478801005913 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 478801005914 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 478801005915 putative homodimer interface [polypeptide binding]; other site 478801005916 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 478801005917 heterodimer interface [polypeptide binding]; other site 478801005918 homodimer interface [polypeptide binding]; other site 478801005919 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 478801005920 aspartate aminotransferase; Provisional; Region: PRK05764 478801005921 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 478801005922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478801005923 homodimer interface [polypeptide binding]; other site 478801005924 catalytic residue [active] 478801005925 Helix-turn-helix domain; Region: HTH_38; pfam13936 478801005926 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 478801005927 Integrase core domain; Region: rve; pfam00665 478801005928 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478801005929 Transposase; Region: HTH_Tnp_1; pfam01527 478801005930 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 478801005931 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478801005932 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478801005933 WHG domain; Region: WHG; pfam13305 478801005934 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 478801005935 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478801005936 adenosine deaminase; Provisional; Region: PRK09358 478801005937 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 478801005938 active site 478801005939 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 478801005940 FAD binding domain; Region: FAD_binding_4; pfam01565 478801005941 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 478801005942 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 478801005943 active site 2 [active] 478801005944 active site 1 [active] 478801005945 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 478801005946 active site 478801005947 catalytic site [active] 478801005948 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 478801005949 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 478801005950 active site 2 [active] 478801005951 active site 1 [active] 478801005952 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 478801005953 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478801005954 NAD(P) binding site [chemical binding]; other site 478801005955 active site 478801005956 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 478801005957 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 478801005958 dimer interface [polypeptide binding]; other site 478801005959 active site 478801005960 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478801005961 acyl-coenzyme A oxidase; Region: PLN02636 478801005962 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478801005963 active site 478801005964 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 478801005965 active site residue [active] 478801005966 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 478801005967 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 478801005968 active site residue [active] 478801005969 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 478801005970 active site residue [active] 478801005971 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 478801005972 putative homotetramer interface [polypeptide binding]; other site 478801005973 putative homodimer interface [polypeptide binding]; other site 478801005974 putative allosteric switch controlling residues; other site 478801005975 putative metal binding site [ion binding]; other site 478801005976 putative homodimer-homodimer interface [polypeptide binding]; other site 478801005977 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 478801005978 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 478801005979 inhibitor-cofactor binding pocket; inhibition site 478801005980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478801005981 catalytic residue [active] 478801005982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801005983 Major Facilitator Superfamily; Region: MFS_1; pfam07690 478801005984 putative substrate translocation pore; other site 478801005985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801005986 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 478801005987 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 478801005988 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 478801005989 Zn binding site [ion binding]; other site 478801005990 heat shock protein HtpX; Provisional; Region: PRK03072 478801005991 Major Facilitator Superfamily; Region: MFS_1; pfam07690 478801005992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801005993 Predicted permeases [General function prediction only]; Region: RarD; COG2962 478801005994 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 478801005995 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 478801005996 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 478801005997 substrate binding pocket [chemical binding]; other site 478801005998 chain length determination region; other site 478801005999 substrate-Mg2+ binding site; other site 478801006000 catalytic residues [active] 478801006001 aspartate-rich region 1; other site 478801006002 active site lid residues [active] 478801006003 aspartate-rich region 2; other site 478801006004 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 478801006005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478801006006 S-adenosylmethionine binding site [chemical binding]; other site 478801006007 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 478801006008 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 478801006009 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 478801006010 dimer interface [polypeptide binding]; other site 478801006011 tetramer interface [polypeptide binding]; other site 478801006012 PYR/PP interface [polypeptide binding]; other site 478801006013 TPP binding site [chemical binding]; other site 478801006014 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 478801006015 TPP-binding site; other site 478801006016 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478801006017 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478801006018 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 478801006019 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478801006020 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 478801006021 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 478801006022 ABC transporter; Region: ABC_tran; pfam00005 478801006023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801006024 Q-loop/lid; other site 478801006025 ABC transporter signature motif; other site 478801006026 Walker B; other site 478801006027 D-loop; other site 478801006028 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 478801006029 dimerization interface [polypeptide binding]; other site 478801006030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478801006031 ATP binding site [chemical binding]; other site 478801006032 G-X-G motif; other site 478801006033 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478801006034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478801006035 active site 478801006036 phosphorylation site [posttranslational modification] 478801006037 intermolecular recognition site; other site 478801006038 dimerization interface [polypeptide binding]; other site 478801006039 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478801006040 DNA binding site [nucleotide binding] 478801006041 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 478801006042 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 478801006043 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 478801006044 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 478801006045 active site 478801006046 Zn binding site [ion binding]; other site 478801006047 Bacterial SH3 domain; Region: SH3_3; pfam08239 478801006048 Bacterial SH3 domain; Region: SH3_3; cl17532 478801006049 Bacterial SH3 domain; Region: SH3_3; pfam08239 478801006050 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 478801006051 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 478801006052 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 478801006053 active site 478801006054 catalytic residues [active] 478801006055 metal binding site [ion binding]; metal-binding site 478801006056 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 478801006057 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 478801006058 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478801006059 ATP binding site [chemical binding]; other site 478801006060 putative Mg++ binding site [ion binding]; other site 478801006061 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478801006062 nucleotide binding region [chemical binding]; other site 478801006063 ATP-binding site [chemical binding]; other site 478801006064 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 478801006065 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 478801006066 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 478801006067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478801006068 active site 478801006069 phosphorylation site [posttranslational modification] 478801006070 intermolecular recognition site; other site 478801006071 dimerization interface [polypeptide binding]; other site 478801006072 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 478801006073 DNA binding site [nucleotide binding] 478801006074 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 478801006075 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 478801006076 dimerization interface [polypeptide binding]; other site 478801006077 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 478801006078 dimer interface [polypeptide binding]; other site 478801006079 phosphorylation site [posttranslational modification] 478801006080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 478801006081 ATP binding site [chemical binding]; other site 478801006082 Mg2+ binding site [ion binding]; other site 478801006083 G-X-G motif; other site 478801006084 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 478801006085 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 478801006086 protein binding site [polypeptide binding]; other site 478801006087 Predicted membrane protein [Function unknown]; Region: COG2364 478801006088 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 478801006089 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 478801006090 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 478801006091 Walker A/P-loop; other site 478801006092 ATP binding site [chemical binding]; other site 478801006093 Q-loop/lid; other site 478801006094 ABC transporter signature motif; other site 478801006095 Walker B; other site 478801006096 D-loop; other site 478801006097 H-loop/switch region; other site 478801006098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478801006099 dimer interface [polypeptide binding]; other site 478801006100 conserved gate region; other site 478801006101 putative PBP binding loops; other site 478801006102 ABC-ATPase subunit interface; other site 478801006103 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 478801006104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478801006105 dimer interface [polypeptide binding]; other site 478801006106 conserved gate region; other site 478801006107 putative PBP binding loops; other site 478801006108 ABC-ATPase subunit interface; other site 478801006109 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 478801006110 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 478801006111 substrate binding pocket [chemical binding]; other site 478801006112 membrane-bound complex binding site; other site 478801006113 hinge residues; other site 478801006114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 478801006115 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 478801006116 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 478801006117 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 478801006118 Part of AAA domain; Region: AAA_19; pfam13245 478801006119 PhoH-like protein; Region: PhoH; cl17668 478801006120 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 478801006121 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 478801006122 ring oligomerisation interface [polypeptide binding]; other site 478801006123 ATP/Mg binding site [chemical binding]; other site 478801006124 stacking interactions; other site 478801006125 hinge regions; other site 478801006126 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 478801006127 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478801006128 motif II; other site 478801006129 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 478801006130 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 478801006131 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 478801006132 PemK-like protein; Region: PemK; pfam02452 478801006133 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 478801006134 ligand binding site [chemical binding]; other site 478801006135 active site 478801006136 UGI interface [polypeptide binding]; other site 478801006137 catalytic site [active] 478801006138 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 478801006139 active site 478801006140 catalytic triad [active] 478801006141 oxyanion hole [active] 478801006142 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 478801006143 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478801006144 active site 478801006145 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 478801006146 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 478801006147 NAD binding site [chemical binding]; other site 478801006148 homodimer interface [polypeptide binding]; other site 478801006149 homotetramer interface [polypeptide binding]; other site 478801006150 active site 478801006151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801006152 putative substrate translocation pore; other site 478801006153 Major Facilitator Superfamily; Region: MFS_1; pfam07690 478801006154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478801006155 active site 478801006156 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 478801006157 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 478801006158 calcium binding site 2 [ion binding]; other site 478801006159 active site 478801006160 catalytic triad [active] 478801006161 calcium binding site 1 [ion binding]; other site 478801006162 ATP-grasp domain; Region: ATP-grasp_4; cl17255 478801006163 TrkA-C domain; Region: TrkA_C; pfam02080 478801006164 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 478801006165 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 478801006166 dimer interface [polypeptide binding]; other site 478801006167 putative radical transfer pathway; other site 478801006168 diiron center [ion binding]; other site 478801006169 tyrosyl radical; other site 478801006170 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 478801006171 ATP cone domain; Region: ATP-cone; pfam03477 478801006172 Class I ribonucleotide reductase; Region: RNR_I; cd01679 478801006173 active site 478801006174 dimer interface [polypeptide binding]; other site 478801006175 catalytic residues [active] 478801006176 effector binding site; other site 478801006177 R2 peptide binding site; other site 478801006178 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 478801006179 putative transposase OrfB; Reviewed; Region: PHA02517 478801006180 HTH-like domain; Region: HTH_21; pfam13276 478801006181 Integrase core domain; Region: rve; pfam00665 478801006182 Integrase core domain; Region: rve_3; pfam13683 478801006183 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 478801006184 DNA-binding interface [nucleotide binding]; DNA binding site 478801006185 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 478801006186 ABC-2 type transporter; Region: ABC2_membrane; cl17235 478801006187 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 478801006188 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 478801006189 Walker A/P-loop; other site 478801006190 ATP binding site [chemical binding]; other site 478801006191 Q-loop/lid; other site 478801006192 ABC transporter signature motif; other site 478801006193 Walker B; other site 478801006194 D-loop; other site 478801006195 H-loop/switch region; other site 478801006196 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478801006197 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478801006198 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 478801006199 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 478801006200 siderophore binding site; other site 478801006201 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 478801006202 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 478801006203 putative PBP binding regions; other site 478801006204 ABC-ATPase subunit interface; other site 478801006205 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 478801006206 ABC-ATPase subunit interface; other site 478801006207 dimer interface [polypeptide binding]; other site 478801006208 putative PBP binding regions; other site 478801006209 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 478801006210 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 478801006211 Walker A/P-loop; other site 478801006212 ATP binding site [chemical binding]; other site 478801006213 Q-loop/lid; other site 478801006214 ABC transporter signature motif; other site 478801006215 Walker B; other site 478801006216 D-loop; other site 478801006217 H-loop/switch region; other site 478801006218 CAAX protease self-immunity; Region: Abi; cl00558 478801006219 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 478801006220 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 478801006221 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 478801006222 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 478801006223 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 478801006224 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 478801006225 Walker A/P-loop; other site 478801006226 ATP binding site [chemical binding]; other site 478801006227 Q-loop/lid; other site 478801006228 ABC transporter signature motif; other site 478801006229 Walker B; other site 478801006230 D-loop; other site 478801006231 H-loop/switch region; other site 478801006232 ArgK protein; Region: ArgK; pfam03308 478801006233 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 478801006234 Walker A; other site 478801006235 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 478801006236 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 478801006237 active site 478801006238 substrate binding site [chemical binding]; other site 478801006239 coenzyme B12 binding site [chemical binding]; other site 478801006240 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 478801006241 B12 binding site [chemical binding]; other site 478801006242 cobalt ligand [ion binding]; other site 478801006243 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 478801006244 FAD binding domain; Region: FAD_binding_4; pfam01565 478801006245 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 478801006246 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 478801006247 putative hydrophobic ligand binding site [chemical binding]; other site 478801006248 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 478801006249 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 478801006250 putative active site [active] 478801006251 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 478801006252 DEAD-like helicases superfamily; Region: DEXDc; smart00487 478801006253 ATP binding site [chemical binding]; other site 478801006254 putative Mg++ binding site [ion binding]; other site 478801006255 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478801006256 nucleotide binding region [chemical binding]; other site 478801006257 ATP-binding site [chemical binding]; other site 478801006258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801006259 putative substrate translocation pore; other site 478801006260 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 478801006261 Tetratricopeptide repeat; Region: TPR_12; pfam13424 478801006262 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 478801006263 TPR motif; other site 478801006264 binding surface 478801006265 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478801006266 MULE transposase domain; Region: MULE; pfam10551 478801006267 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478801006268 putative DNA binding site [nucleotide binding]; other site 478801006269 dimerization interface [polypeptide binding]; other site 478801006270 putative Zn2+ binding site [ion binding]; other site 478801006271 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 478801006272 putative hydrophobic ligand binding site [chemical binding]; other site 478801006273 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 478801006274 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478801006275 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 478801006276 Protein of unknown function (DUF1178); Region: DUF1178; cl17833 478801006277 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 478801006278 Citrate transporter; Region: CitMHS; pfam03600 478801006279 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 478801006280 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 478801006281 PGAP1-like protein; Region: PGAP1; pfam07819 478801006282 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478801006283 Cytochrome P450; Region: p450; cl12078 478801006284 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 478801006285 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 478801006286 FMN-binding pocket [chemical binding]; other site 478801006287 flavin binding motif; other site 478801006288 phosphate binding motif [ion binding]; other site 478801006289 beta-alpha-beta structure motif; other site 478801006290 NAD binding pocket [chemical binding]; other site 478801006291 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 478801006292 catalytic loop [active] 478801006293 iron binding site [ion binding]; other site 478801006294 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 478801006295 hypothetical protein; Provisional; Region: PRK05463 478801006296 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 478801006297 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 478801006298 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 478801006299 putative NAD(P) binding site [chemical binding]; other site 478801006300 catalytic Zn binding site [ion binding]; other site 478801006301 structural Zn binding site [ion binding]; other site 478801006302 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 478801006303 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478801006304 Coenzyme A binding pocket [chemical binding]; other site 478801006305 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 478801006306 Nucleoside recognition; Region: Gate; pfam07670 478801006307 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 478801006308 dimerization interface [polypeptide binding]; other site 478801006309 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 478801006310 transmembrane helices; other site 478801006311 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 478801006312 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 478801006313 Coenzyme A binding pocket [chemical binding]; other site 478801006314 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 478801006315 Fic family protein [Function unknown]; Region: COG3177 478801006316 Fic/DOC family; Region: Fic; pfam02661 478801006317 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 478801006318 putative active site [active] 478801006319 Rv0623-like transcription factor; Region: PSK_trans_fac; cl01834 478801006320 Protein of unknown function DUF262; Region: DUF262; pfam03235 478801006321 Uncharacterized conserved protein [Function unknown]; Region: COG1479 478801006322 Protein of unknown function DUF262; Region: DUF262; pfam03235 478801006323 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 478801006324 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 478801006325 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 478801006326 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478801006327 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 478801006328 Bacterial SH3 domain; Region: SH3_3; cl17532 478801006329 Bacterial SH3 domain; Region: SH3_3; pfam08239 478801006330 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 478801006331 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 478801006332 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 478801006333 putative active site [active] 478801006334 putative metal binding site [ion binding]; other site 478801006335 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 478801006336 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577 478801006337 putative active site [active] 478801006338 catalytic site [active] 478801006339 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 478801006340 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 478801006341 Homeodomain-like domain; Region: HTH_23; cl17451 478801006342 Winged helix-turn helix; Region: HTH_29; pfam13551 478801006343 Integrase core domain; Region: rve; pfam00665 478801006344 Integrase core domain; Region: rve_3; pfam13683 478801006345 HsdM N-terminal domain; Region: HsdM_N; pfam12161 478801006346 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 478801006347 Methyltransferase domain; Region: Methyltransf_26; pfam13659 478801006348 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 478801006349 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 478801006350 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 478801006351 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478801006352 ATP binding site [chemical binding]; other site 478801006353 putative Mg++ binding site [ion binding]; other site 478801006354 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 478801006355 Mrr N-terminal domain; Region: Mrr_N; pfam14338 478801006356 Restriction endonuclease; Region: Mrr_cat; pfam04471 478801006357 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 478801006358 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478801006359 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 478801006360 Protein of unknown function (DUF917); Region: DUF917; cl17829 478801006361 Protein of unknown function (DUF917); Region: DUF917; pfam06032 478801006362 Protein of unknown function (DUF917); Region: DUF917; pfam06032 478801006363 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 478801006364 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 478801006365 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 478801006366 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 478801006367 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 478801006368 Na binding site [ion binding]; other site 478801006369 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 478801006370 Helix-turn-helix domain; Region: HTH_38; pfam13936 478801006371 Homeodomain-like domain; Region: HTH_32; pfam13565 478801006372 Integrase core domain; Region: rve; pfam00665 478801006373 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 478801006374 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 478801006375 AAA domain; Region: AAA_30; pfam13604 478801006376 AAA domain; Region: AAA_30; pfam13604 478801006377 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 478801006378 AAA domain; Region: AAA_12; pfam13087 478801006379 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478801006380 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 478801006381 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478801006382 NAD(P) binding site [chemical binding]; other site 478801006383 active site 478801006384 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 478801006385 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 478801006386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 478801006387 Methyltransferase domain; Region: Methyltransf_23; pfam13489 478801006388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478801006389 S-adenosylmethionine binding site [chemical binding]; other site 478801006390 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 478801006391 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 478801006392 non-specific DNA interactions [nucleotide binding]; other site 478801006393 DNA binding site [nucleotide binding] 478801006394 sequence specific DNA binding site [nucleotide binding]; other site 478801006395 putative cAMP binding site [chemical binding]; other site 478801006396 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 478801006397 Methyltransferase domain; Region: Methyltransf_31; pfam13847 478801006398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478801006399 S-adenosylmethionine binding site [chemical binding]; other site 478801006400 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478801006401 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 478801006402 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 478801006403 metal binding site [ion binding]; metal-binding site 478801006404 dimer interface [polypeptide binding]; other site 478801006405 arogenate dehydrogenase; Region: PLN02256 478801006406 Chorismate mutase type II; Region: CM_2; pfam01817 478801006407 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 478801006408 Prephenate dehydratase; Region: PDT; pfam00800 478801006409 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 478801006410 putative L-Phe binding site [chemical binding]; other site 478801006411 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 478801006412 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 478801006413 dimerization interface [polypeptide binding]; other site 478801006414 active site 478801006415 FAD binding domain; Region: FAD_binding_2; pfam00890 478801006416 L-aspartate oxidase; Provisional; Region: PRK06175 478801006417 quinolinate synthetase; Provisional; Region: PRK09375 478801006418 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 478801006419 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 478801006420 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 478801006421 active site 478801006422 phosphate binding residues; other site 478801006423 catalytic residues [active] 478801006424 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 478801006425 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 478801006426 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 478801006427 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 478801006428 dimer interface [polypeptide binding]; other site 478801006429 active site 478801006430 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 478801006431 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 478801006432 putative di-iron ligands [ion binding]; other site 478801006433 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 478801006434 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 478801006435 FAD binding pocket [chemical binding]; other site 478801006436 FAD binding motif [chemical binding]; other site 478801006437 phosphate binding motif [ion binding]; other site 478801006438 beta-alpha-beta structure motif; other site 478801006439 NAD binding pocket [chemical binding]; other site 478801006440 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 478801006441 catalytic loop [active] 478801006442 iron binding site [ion binding]; other site 478801006443 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 478801006444 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 478801006445 active site 478801006446 catalytic triad [active] 478801006447 oxyanion hole [active] 478801006448 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 478801006449 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 478801006450 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 478801006451 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 478801006452 L-aspartate oxidase; Provisional; Region: PRK06175 478801006453 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 478801006454 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 478801006455 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 478801006456 putative Iron-sulfur protein interface [polypeptide binding]; other site 478801006457 proximal heme binding site [chemical binding]; other site 478801006458 distal heme binding site [chemical binding]; other site 478801006459 putative dimer interface [polypeptide binding]; other site 478801006460 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 478801006461 Bacterial PH domain; Region: DUF304; pfam03703 478801006462 Bacterial PH domain; Region: DUF304; pfam03703 478801006463 Uncharacterized conserved protein [Function unknown]; Region: COG3402 478801006464 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 478801006465 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 478801006466 potential catalytic triad [active] 478801006467 conserved cys residue [active] 478801006468 Domain of unknown function (DUF305); Region: DUF305; pfam03713 478801006469 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 478801006470 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 478801006471 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 478801006472 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 478801006473 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478801006474 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478801006475 motif II; other site 478801006476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478801006477 Transposase; Region: HTH_Tnp_1; pfam01527 478801006478 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 478801006479 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478801006480 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 478801006481 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478801006482 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 478801006483 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 478801006484 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 478801006485 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 478801006486 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 478801006487 DNA binding residues [nucleotide binding] 478801006488 putative dimer interface [polypeptide binding]; other site 478801006489 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 478801006490 Transposase; Region: HTH_Tnp_1; pfam01527 478801006491 putative transposase OrfB; Reviewed; Region: PHA02517 478801006492 Integrase core domain; Region: rve; pfam00665 478801006493 Integrase core domain; Region: rve_2; pfam13333 478801006494 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 478801006495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801006496 putative substrate translocation pore; other site 478801006497 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 478801006498 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 478801006499 DNA binding residues [nucleotide binding] 478801006500 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 478801006501 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 478801006502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801006503 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 478801006504 Walker A/P-loop; other site 478801006505 ATP binding site [chemical binding]; other site 478801006506 Q-loop/lid; other site 478801006507 ABC transporter signature motif; other site 478801006508 Walker B; other site 478801006509 D-loop; other site 478801006510 H-loop/switch region; other site 478801006511 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 478801006512 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478801006513 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 478801006514 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 478801006515 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 478801006516 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 478801006517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 478801006518 active site 478801006519 phosphorylation site [posttranslational modification] 478801006520 intermolecular recognition site; other site 478801006521 dimerization interface [polypeptide binding]; other site 478801006522 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 478801006523 DNA binding residues [nucleotide binding] 478801006524 dimerization interface [polypeptide binding]; other site 478801006525 Histidine kinase; Region: HisKA_3; pfam07730 478801006526 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 478801006527 ATP binding site [chemical binding]; other site 478801006528 Mg2+ binding site [ion binding]; other site 478801006529 G-X-G motif; other site 478801006530 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 478801006531 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801006532 Walker A/P-loop; other site 478801006533 ATP binding site [chemical binding]; other site 478801006534 Q-loop/lid; other site 478801006535 ABC transporter signature motif; other site 478801006536 Walker B; other site 478801006537 D-loop; other site 478801006538 H-loop/switch region; other site 478801006539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 478801006540 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 478801006541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 478801006542 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 478801006543 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 478801006544 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 478801006545 MarR family; Region: MarR; pfam01047 478801006546 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 478801006547 Winged helix-turn helix; Region: HTH_29; pfam13551 478801006548 Homeodomain-like domain; Region: HTH_32; pfam13565 478801006549 Integrase core domain; Region: rve; pfam00665 478801006550 Integrase core domain; Region: rve_3; pfam13683 478801006551 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 478801006552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 478801006553 putative substrate translocation pore; other site 478801006554 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 478801006555 NADH(P)-binding; Region: NAD_binding_10; pfam13460 478801006556 NAD binding site [chemical binding]; other site 478801006557 substrate binding site [chemical binding]; other site 478801006558 putative active site [active] 478801006559 Transcriptional regulators [Transcription]; Region: MarR; COG1846 478801006560 MarR family; Region: MarR_2; pfam12802 478801006561 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 478801006562 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478801006563 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 478801006564 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 478801006565 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 478801006566 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 478801006567 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 478801006568 active site 478801006569 tetramer interface; other site 478801006570 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 478801006571 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 478801006572 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 478801006573 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 478801006574 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 478801006575 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 478801006576 putative hydrophobic ligand binding site [chemical binding]; other site 478801006577 AAA domain; Region: AAA_23; pfam13476 478801006578 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 478801006579 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 478801006580 active site 478801006581 metal binding site [ion binding]; metal-binding site 478801006582 DNA binding site [nucleotide binding] 478801006583 CrcB-like protein; Region: CRCB; pfam02537 478801006584 Domain of unknown function DUF21; Region: DUF21; pfam01595 478801006585 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 478801006586 FOG: CBS domain [General function prediction only]; Region: COG0517 478801006587 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 478801006588 Domain of unknown function DUF21; Region: DUF21; pfam01595 478801006589 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 478801006590 Transporter associated domain; Region: CorC_HlyC; smart01091 478801006591 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 478801006592 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 478801006593 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 478801006594 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 478801006595 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 478801006596 putative dimer interface [polypeptide binding]; other site 478801006597 catalytic triad [active] 478801006598 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 478801006599 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 478801006600 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 478801006601 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 478801006602 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 478801006603 Zn binding site [ion binding]; other site 478801006604 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 478801006605 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 478801006606 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 478801006607 DNA-binding site [nucleotide binding]; DNA binding site 478801006608 RNA-binding motif; other site 478801006609 O-succinylbenzoate synthase; Provisional; Region: PRK02901 478801006610 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 478801006611 metal binding site [ion binding]; metal-binding site 478801006612 substrate binding pocket [chemical binding]; other site 478801006613 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 478801006614 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 478801006615 substrate binding site [chemical binding]; other site 478801006616 oxyanion hole (OAH) forming residues; other site 478801006617 trimer interface [polypeptide binding]; other site 478801006618 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 478801006619 AMP binding site [chemical binding]; other site 478801006620 active site 478801006621 acyl-activating enzyme (AAE) consensus motif; other site 478801006622 CoA binding site [chemical binding]; other site 478801006623 H+ Antiporter protein; Region: 2A0121; TIGR00900 478801006624 muropeptide transporter; Validated; Region: ampG; cl17669 478801006625 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 478801006626 putative FMN binding site [chemical binding]; other site 478801006627 NADPH bind site [chemical binding]; other site 478801006628 ATP-grasp domain; Region: ATP-grasp_4; cl17255 478801006629 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 478801006630 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478801006631 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478801006632 MULE transposase domain; Region: MULE; pfam10551 478801006633 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 478801006634 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 478801006635 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 478801006636 UbiA prenyltransferase family; Region: UbiA; pfam01040 478801006637 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 478801006638 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 478801006639 ResB-like family; Region: ResB; pfam05140 478801006640 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 478801006641 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 478801006642 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 478801006643 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 478801006644 catalytic residues [active] 478801006645 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 478801006646 catalytic core [active] 478801006647 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 478801006648 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 478801006649 inhibitor-cofactor binding pocket; inhibition site 478801006650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478801006651 catalytic residue [active] 478801006652 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 478801006653 dimer interface [polypeptide binding]; other site 478801006654 active site 478801006655 Schiff base residues; other site 478801006656 Uroporphyrinogen-III methylase [Coenzyme metabolism]; Region: CysG; COG0007 478801006657 homodimer interface [polypeptide binding]; other site 478801006658 active site 478801006659 SAM binding site [chemical binding]; other site 478801006660 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 478801006661 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 478801006662 active site 478801006663 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 478801006664 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 478801006665 domain interfaces; other site 478801006666 active site 478801006667 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 478801006668 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 478801006669 NAD(P) binding pocket [chemical binding]; other site 478801006670 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 478801006671 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 478801006672 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 478801006673 active site 478801006674 Zn binding site [ion binding]; other site 478801006675 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 478801006676 TrkA-N domain; Region: TrkA_N; pfam02254 478801006677 TrkA-C domain; Region: TrkA_C; pfam02080 478801006678 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 478801006679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478801006680 Coenzyme A binding pocket [chemical binding]; other site 478801006681 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478801006682 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 478801006683 Coenzyme A binding pocket [chemical binding]; other site 478801006684 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 478801006685 pyrroline-5-carboxylate reductase; Region: PLN02688 478801006686 Proline dehydrogenase; Region: Pro_dh; cl03282 478801006687 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478801006688 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478801006689 WYL domain; Region: WYL; pfam13280 478801006690 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 478801006691 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 478801006692 Homeodomain-like domain; Region: HTH_23; cl17451 478801006693 Winged helix-turn helix; Region: HTH_29; pfam13551 478801006694 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 478801006695 Integrase core domain; Region: rve; pfam00665 478801006696 Integrase core domain; Region: rve_3; pfam13683 478801006697 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 478801006698 exopolyphosphatase; Region: exo_poly_only; TIGR03706 478801006699 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 478801006700 DNA repair protein RadA; Provisional; Region: PRK11823 478801006701 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 478801006702 Walker A motif; other site 478801006703 ATP binding site [chemical binding]; other site 478801006704 Walker B motif; other site 478801006705 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 478801006706 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 478801006707 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 478801006708 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 478801006709 minor groove reading motif; other site 478801006710 helix-hairpin-helix signature motif; other site 478801006711 active site 478801006712 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 478801006713 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 478801006714 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 478801006715 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 478801006716 Clp amino terminal domain; Region: Clp_N; pfam02861 478801006717 Clp amino terminal domain; Region: Clp_N; pfam02861 478801006718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478801006719 Walker A motif; other site 478801006720 ATP binding site [chemical binding]; other site 478801006721 Walker B motif; other site 478801006722 arginine finger; other site 478801006723 UvrB/uvrC motif; Region: UVR; pfam02151 478801006724 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478801006725 Walker A motif; other site 478801006726 ATP binding site [chemical binding]; other site 478801006727 Walker B motif; other site 478801006728 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 478801006729 Low molecular weight phosphatase family; Region: LMWPc; cd00115 478801006730 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 478801006731 active site 478801006732 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 478801006733 Chain length determinant protein; Region: Wzz; pfam02706 478801006734 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 478801006735 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 478801006736 Lsr2; Region: Lsr2; pfam11774 478801006737 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 478801006738 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 478801006739 dimer interface [polypeptide binding]; other site 478801006740 putative anticodon binding site; other site 478801006741 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 478801006742 motif 1; other site 478801006743 dimer interface [polypeptide binding]; other site 478801006744 active site 478801006745 motif 2; other site 478801006746 motif 3; other site 478801006747 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 478801006748 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 478801006749 DNA binding site [nucleotide binding] 478801006750 active site 478801006751 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 478801006752 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 478801006753 AlkA N-terminal domain; Region: AlkA_N; pfam06029 478801006754 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 478801006755 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 478801006756 minor groove reading motif; other site 478801006757 helix-hairpin-helix signature motif; other site 478801006758 substrate binding pocket [chemical binding]; other site 478801006759 active site 478801006760 Rossmann-like domain; Region: Rossmann-like; pfam10727 478801006761 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 478801006762 active site 478801006763 catalytic triad [active] 478801006764 oxyanion hole [active] 478801006765 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 478801006766 nudix motif; other site 478801006767 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 478801006768 CGNR zinc finger; Region: zf-CGNR; pfam11706 478801006769 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 478801006770 Dihydroneopterin aldolase; Region: FolB; smart00905 478801006771 active site 478801006772 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 478801006773 catalytic center binding site [active] 478801006774 ATP binding site [chemical binding]; other site 478801006775 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 478801006776 dihydropteroate synthase; Region: DHPS; TIGR01496 478801006777 substrate binding pocket [chemical binding]; other site 478801006778 dimer interface [polypeptide binding]; other site 478801006779 inhibitor binding site; inhibition site 478801006780 GTP cyclohydrolase I; Provisional; Region: PLN03044 478801006781 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 478801006782 homodecamer interface [polypeptide binding]; other site 478801006783 active site 478801006784 putative catalytic site residues [active] 478801006785 zinc binding site [ion binding]; other site 478801006786 GTP-CH-I/GFRP interaction surface; other site 478801006787 FtsH Extracellular; Region: FtsH_ext; pfam06480 478801006788 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 478801006789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478801006790 Walker A motif; other site 478801006791 ATP binding site [chemical binding]; other site 478801006792 Walker B motif; other site 478801006793 arginine finger; other site 478801006794 Peptidase family M41; Region: Peptidase_M41; pfam01434 478801006795 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 478801006796 active site 478801006797 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 478801006798 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 478801006799 Ligand Binding Site [chemical binding]; other site 478801006800 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 478801006801 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 478801006802 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 478801006803 dimer interface [polypeptide binding]; other site 478801006804 substrate binding site [chemical binding]; other site 478801006805 metal binding sites [ion binding]; metal-binding site 478801006806 YCII-related domain; Region: YCII; cl00999 478801006807 TAP-like protein; Region: Abhydrolase_4; pfam08386 478801006808 DNA polymerase III subunit delta'; Validated; Region: PRK07940 478801006809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 478801006810 Walker A motif; other site 478801006811 ATP binding site [chemical binding]; other site 478801006812 DNA polymerase III subunit delta'; Validated; Region: PRK08485 478801006813 Walker B motif; other site 478801006814 thymidylate kinase; Validated; Region: tmk; PRK00698 478801006815 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 478801006816 TMP-binding site; other site 478801006817 ATP-binding site [chemical binding]; other site 478801006818 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 478801006819 MarR family; Region: MarR_2; pfam12802 478801006820 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 478801006821 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 478801006822 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 478801006823 Protein of unknown function (DUF779); Region: DUF779; pfam05610 478801006824 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 478801006825 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 478801006826 NAD(P) binding site [chemical binding]; other site 478801006827 catalytic residues [active] 478801006828 Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976 478801006829 NodB motif; other site 478801006830 putative active site [active] 478801006831 putative catalytic site [active] 478801006832 Repair protein; Region: Repair_PSII; pfam04536 478801006833 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 478801006834 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 478801006835 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 478801006836 catalytic residue [active] 478801006837 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 478801006838 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 478801006839 DNA binding residues [nucleotide binding] 478801006840 dimer interface [polypeptide binding]; other site 478801006841 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 478801006842 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 478801006843 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 478801006844 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 478801006845 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 478801006846 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478801006847 Coenzyme A binding pocket [chemical binding]; other site 478801006848 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 478801006849 Coenzyme A binding pocket [chemical binding]; other site 478801006850 Helix-turn-helix domain; Region: HTH_18; pfam12833 478801006851 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 478801006852 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 478801006853 putative dimer interface [polypeptide binding]; other site 478801006854 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478801006855 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 478801006856 putative active site [active] 478801006857 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 478801006858 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 478801006859 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 478801006860 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 478801006861 active site 478801006862 interdomain interaction site; other site 478801006863 putative metal-binding site [ion binding]; other site 478801006864 nucleotide binding site [chemical binding]; other site 478801006865 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 478801006866 domain I; other site 478801006867 phosphate binding site [ion binding]; other site 478801006868 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 478801006869 domain II; other site 478801006870 domain III; other site 478801006871 nucleotide binding site [chemical binding]; other site 478801006872 DNA binding groove [nucleotide binding] 478801006873 catalytic site [active] 478801006874 domain IV; other site 478801006875 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 478801006876 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 478801006877 Fic family protein [Function unknown]; Region: COG3177 478801006878 Fic/DOC family; Region: Fic; pfam02661 478801006879 RibD C-terminal domain; Region: RibD_C; cl17279 478801006880 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 478801006881 putative active site [active] 478801006882 Transposase; Region: HTH_Tnp_1; pfam01527 478801006883 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 478801006884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 478801006885 S-adenosylmethionine binding site [chemical binding]; other site 478801006886 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 478801006887 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 478801006888 LemA family; Region: LemA; cl00742 478801006889 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478801006890 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478801006891 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 478801006892 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 478801006893 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 478801006894 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801006895 Walker A/P-loop; other site 478801006896 ATP binding site [chemical binding]; other site 478801006897 Q-loop/lid; other site 478801006898 ABC transporter signature motif; other site 478801006899 Walker B; other site 478801006900 D-loop; other site 478801006901 H-loop/switch region; other site 478801006902 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 478801006903 ABC-2 type transporter; Region: ABC2_membrane; cl17235 478801006904 ABC-2 type transporter; Region: ABC2_membrane; cl17235 478801006905 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 478801006906 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 478801006907 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 478801006908 ATP binding site [chemical binding]; other site 478801006909 putative Mg++ binding site [ion binding]; other site 478801006910 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 478801006911 ATP-binding site [chemical binding]; other site 478801006912 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 478801006913 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 478801006914 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 478801006915 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 478801006916 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 478801006917 ATP binding site [chemical binding]; other site 478801006918 Walker A motif; other site 478801006919 hexamer interface [polypeptide binding]; other site 478801006920 Walker B motif; other site 478801006921 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 478801006922 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 478801006923 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 478801006924 Walker A/P-loop; other site 478801006925 ATP binding site [chemical binding]; other site 478801006926 Q-loop/lid; other site 478801006927 ABC transporter signature motif; other site 478801006928 Walker B; other site 478801006929 D-loop; other site 478801006930 H-loop/switch region; other site 478801006931 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 478801006932 ABC-ATPase subunit interface; other site 478801006933 dimer interface [polypeptide binding]; other site 478801006934 putative PBP binding regions; other site 478801006935 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 478801006936 ABC-ATPase subunit interface; other site 478801006937 dimer interface [polypeptide binding]; other site 478801006938 putative PBP binding regions; other site 478801006939 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 478801006940 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 478801006941 intersubunit interface [polypeptide binding]; other site 478801006942 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 478801006943 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 478801006944 putative active site [active] 478801006945 putative CoA binding site [chemical binding]; other site 478801006946 nudix motif; other site 478801006947 metal binding site [ion binding]; metal-binding site 478801006948 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 478801006949 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 478801006950 minor groove reading motif; other site 478801006951 helix-hairpin-helix signature motif; other site 478801006952 substrate binding pocket [chemical binding]; other site 478801006953 active site 478801006954 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 478801006955 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 478801006956 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 478801006957 ligand binding site [chemical binding]; other site 478801006958 flexible hinge region; other site 478801006959 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 478801006960 putative switch regulator; other site 478801006961 non-specific DNA interactions [nucleotide binding]; other site 478801006962 DNA binding site [nucleotide binding] 478801006963 sequence specific DNA binding site [nucleotide binding]; other site 478801006964 putative cAMP binding site [chemical binding]; other site 478801006965 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 478801006966 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 478801006967 homotrimer interaction site [polypeptide binding]; other site 478801006968 putative active site [active] 478801006969 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 478801006970 Transglycosylase; Region: Transgly; pfam00912 478801006971 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 478801006972 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 478801006973 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 478801006974 Yqey-like protein; Region: YqeY; cl17540 478801006975 phosphodiesterase YaeI; Provisional; Region: PRK11340 478801006976 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 478801006977 putative active site [active] 478801006978 putative metal binding site [ion binding]; other site 478801006979 short chain dehydrogenase; Provisional; Region: PRK08278 478801006980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478801006981 NAD(P) binding site [chemical binding]; other site 478801006982 active site 478801006983 aspartate kinase III; Validated; Region: PRK09084 478801006984 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 478801006985 nucleotide binding site [chemical binding]; other site 478801006986 substrate binding site [chemical binding]; other site 478801006987 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 478801006988 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 478801006989 Uncharacterized conserved protein [Function unknown]; Region: COG2353 478801006990 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 478801006991 active site 478801006992 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478801006993 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 478801006994 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 478801006995 Coenzyme A binding pocket [chemical binding]; other site 478801006996 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 478801006997 active site 478801006998 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 478801006999 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 478801007000 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 478801007001 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 478801007002 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH10; cd08263 478801007003 putative NAD(P) binding site [chemical binding]; other site 478801007004 catalytic Zn binding site [ion binding]; other site 478801007005 structural Zn binding site [ion binding]; other site 478801007006 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 478801007007 CoA-transferase family III; Region: CoA_transf_3; pfam02515 478801007008 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 478801007009 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478801007010 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 478801007011 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 478801007012 DNA binding residues [nucleotide binding] 478801007013 dimer interface [polypeptide binding]; other site 478801007014 metal binding site [ion binding]; metal-binding site 478801007015 mercuric reductase; Region: MerA; TIGR02053 478801007016 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478801007017 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 478801007018 alkylmercury lyase; Provisional; Region: PRK13239 478801007019 Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324 478801007020 Alkylmercury lyase; Region: MerB; pfam03243 478801007021 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 478801007022 Transposase; Region: DDE_Tnp_ISL3; pfam01610 478801007023 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 478801007024 Cadmium resistance transporter; Region: Cad; pfam03596 478801007025 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478801007026 dimerization interface [polypeptide binding]; other site 478801007027 putative DNA binding site [nucleotide binding]; other site 478801007028 putative Zn2+ binding site [ion binding]; other site 478801007029 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 478801007030 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 478801007031 catalytic residues [active] 478801007032 catalytic nucleophile [active] 478801007033 Presynaptic Site I dimer interface [polypeptide binding]; other site 478801007034 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 478801007035 Synaptic Flat tetramer interface [polypeptide binding]; other site 478801007036 Synaptic Site I dimer interface [polypeptide binding]; other site 478801007037 DNA binding site [nucleotide binding] 478801007038 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 478801007039 DNA-binding interface [nucleotide binding]; DNA binding site 478801007040 Integrase core domain; Region: rve; pfam00665 478801007041 transposase; Provisional; Region: PRK06526 478801007042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478801007043 Walker A motif; other site 478801007044 ATP binding site [chemical binding]; other site 478801007045 Walker B motif; other site 478801007046 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 478801007047 Cadmium resistance transporter; Region: Cad; pfam03596 478801007048 lipoprotein signal peptidase; Provisional; Region: PRK14769 478801007049 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 478801007050 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 478801007051 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 478801007052 active site 478801007053 motif I; other site 478801007054 motif II; other site 478801007055 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478801007056 dimerization interface [polypeptide binding]; other site 478801007057 putative DNA binding site [nucleotide binding]; other site 478801007058 putative Zn2+ binding site [ion binding]; other site 478801007059 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 478801007060 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 478801007061 Walker A/P-loop; other site 478801007062 ATP binding site [chemical binding]; other site 478801007063 Q-loop/lid; other site 478801007064 ABC transporter signature motif; other site 478801007065 Walker B; other site 478801007066 D-loop; other site 478801007067 H-loop/switch region; other site 478801007068 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 478801007069 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 478801007070 Cytochrome P450; Region: p450; cl12078 478801007071 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478801007072 MULE transposase domain; Region: MULE; pfam10551 478801007073 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478801007074 dimerization interface [polypeptide binding]; other site 478801007075 putative DNA binding site [nucleotide binding]; other site 478801007076 putative Zn2+ binding site [ion binding]; other site 478801007077 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 478801007078 putative active site [active] 478801007079 redox center [active] 478801007080 Thioredoxin; Region: Thioredoxin_4; pfam13462 478801007081 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 478801007082 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 478801007083 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 478801007084 putative active site [active] 478801007085 catalytic triad [active] 478801007086 putative dimer interface [polypeptide binding]; other site 478801007087 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 478801007088 Transposase, Mutator family; Region: Transposase_mut; pfam00872 478801007089 MULE transposase domain; Region: MULE; pfam10551 478801007090 recombination protein RecR; Reviewed; Region: recR; PRK00076 478801007091 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 478801007092 RecR protein; Region: RecR; pfam02132 478801007093 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 478801007094 putative active site [active] 478801007095 putative metal-binding site [ion binding]; other site 478801007096 tetramer interface [polypeptide binding]; other site 478801007097 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 478801007098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 478801007099 Walker A motif; other site 478801007100 ATP binding site [chemical binding]; other site 478801007101 Walker B motif; other site 478801007102 arginine finger; other site 478801007103 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 478801007104 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 478801007105 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 478801007106 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 478801007107 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 478801007108 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 478801007109 hydrophobic ligand binding site; other site 478801007110 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 478801007111 nucleoside/Zn binding site; other site 478801007112 dimer interface [polypeptide binding]; other site 478801007113 catalytic motif [active] 478801007114 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 478801007115 active site 478801007116 Bacterial PH domain; Region: DUF304; pfam03703 478801007117 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 478801007118 active site 478801007119 catalytic residues [active] 478801007120 metal binding site [ion binding]; metal-binding site 478801007121 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 478801007122 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 478801007123 Transcriptional regulator [Transcription]; Region: LytR; COG1316 478801007124 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 478801007125 DNA-binding site [nucleotide binding]; DNA binding site 478801007126 RNA-binding motif; other site 478801007127 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 478801007128 IHF - DNA interface [nucleotide binding]; other site 478801007129 IHF dimer interface [polypeptide binding]; other site 478801007130 serine O-acetyltransferase; Region: cysE; TIGR01172 478801007131 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 478801007132 trimer interface [polypeptide binding]; other site 478801007133 active site 478801007134 substrate binding site [chemical binding]; other site 478801007135 CoA binding site [chemical binding]; other site 478801007136 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 478801007137 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 478801007138 dimer interface [polypeptide binding]; other site 478801007139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 478801007140 catalytic residue [active] 478801007141 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 478801007142 4Fe-4S binding domain; Region: Fer4; pfam00037 478801007143 Cysteine-rich domain; Region: CCG; pfam02754 478801007144 Cysteine-rich domain; Region: CCG; pfam02754 478801007145 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478801007146 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478801007147 active site 478801007148 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 478801007149 pentamer interface [polypeptide binding]; other site 478801007150 dodecaamer interface [polypeptide binding]; other site 478801007151 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 478801007152 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 478801007153 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 478801007154 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 478801007155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478801007156 ABC-ATPase subunit interface; other site 478801007157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478801007158 dimer interface [polypeptide binding]; other site 478801007159 conserved gate region; other site 478801007160 ABC-ATPase subunit interface; other site 478801007161 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 478801007162 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 478801007163 Walker A/P-loop; other site 478801007164 ATP binding site [chemical binding]; other site 478801007165 Q-loop/lid; other site 478801007166 ABC transporter signature motif; other site 478801007167 Walker B; other site 478801007168 D-loop; other site 478801007169 H-loop/switch region; other site 478801007170 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 478801007171 trimer interface [polypeptide binding]; other site 478801007172 active site 478801007173 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 478801007174 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 478801007175 Walker A/P-loop; other site 478801007176 ATP binding site [chemical binding]; other site 478801007177 Q-loop/lid; other site 478801007178 ABC transporter signature motif; other site 478801007179 Walker B; other site 478801007180 D-loop; other site 478801007181 H-loop/switch region; other site 478801007182 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 478801007183 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 478801007184 Walker A/P-loop; other site 478801007185 ATP binding site [chemical binding]; other site 478801007186 Q-loop/lid; other site 478801007187 ABC transporter signature motif; other site 478801007188 Walker B; other site 478801007189 D-loop; other site 478801007190 H-loop/switch region; other site 478801007191 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 478801007192 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 478801007193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478801007194 dimer interface [polypeptide binding]; other site 478801007195 conserved gate region; other site 478801007196 putative PBP binding loops; other site 478801007197 ABC-ATPase subunit interface; other site 478801007198 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 478801007199 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 478801007200 DNA binding residues [nucleotide binding] 478801007201 SnoaL-like domain; Region: SnoaL_2; pfam12680 478801007202 Uncharacterized conserved protein [Function unknown]; Region: COG2128 478801007203 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 478801007204 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 478801007205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 478801007206 putative PBP binding loops; other site 478801007207 ABC-ATPase subunit interface; other site 478801007208 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 478801007209 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 478801007210 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 478801007211 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 478801007212 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 478801007213 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 478801007214 Walker A/P-loop; other site 478801007215 ATP binding site [chemical binding]; other site 478801007216 Q-loop/lid; other site 478801007217 ABC transporter signature motif; other site 478801007218 Walker B; other site 478801007219 D-loop; other site 478801007220 H-loop/switch region; other site 478801007221 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 478801007222 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 478801007223 active site 478801007224 FMN binding site [chemical binding]; other site 478801007225 substrate binding site [chemical binding]; other site 478801007226 homotetramer interface [polypeptide binding]; other site 478801007227 catalytic residue [active] 478801007228 Low molecular weight phosphatase family; Region: LMWPc; cl00105 478801007229 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 478801007230 active site 478801007231 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 478801007232 putative DNA binding site [nucleotide binding]; other site 478801007233 putative Zn2+ binding site [ion binding]; other site 478801007234 Transcriptional regulators [Transcription]; Region: MarR; COG1846 478801007235 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 478801007236 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 478801007237 putative metal binding site [ion binding]; other site 478801007238 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 478801007239 arsenical-resistance protein; Region: acr3; TIGR00832 478801007240 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 478801007241 Low molecular weight phosphatase family; Region: LMWPc; cd00115 478801007242 active site 478801007243 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 478801007244 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 478801007245 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 478801007246 Domain of unknown function (DUF222); Region: DUF222; pfam02720 478801007247 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 478801007248 active site 478801007249 biotin synthase; Validated; Region: PRK06256 478801007250 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 478801007251 FeS/SAM binding site; other site 478801007252 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 478801007253 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 478801007254 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 478801007255 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 478801007256 active site 478801007257 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 478801007258 Predicted amidohydrolase [General function prediction only]; Region: COG0388 478801007259 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 478801007260 putative active site [active] 478801007261 catalytic triad [active] 478801007262 putative dimer interface [polypeptide binding]; other site 478801007263 Copper resistance protein D; Region: CopD; pfam05425 478801007264 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 478801007265 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 478801007266 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 478801007267 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 478801007268 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 478801007269 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 478801007270 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 478801007271 dimer interface [polypeptide binding]; other site 478801007272 ssDNA binding site [nucleotide binding]; other site 478801007273 tetramer (dimer of dimers) interface [polypeptide binding]; other site 478801007274 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 478801007275 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 478801007276 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 478801007277 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 478801007278 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 478801007279 putative ADP-binding pocket [chemical binding]; other site 478801007280 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 478801007281 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 478801007282 active site 478801007283 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 478801007284 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 478801007285 active site 478801007286 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; pfam02709 478801007287 Acyltransferase family; Region: Acyl_transf_3; pfam01757 478801007288 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 478801007289 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 478801007290 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 478801007291 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 478801007292 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 478801007293 active site 478801007294 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 478801007295 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 478801007296 active site 478801007297 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 478801007298 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 478801007299 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 478801007300 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 478801007301 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 478801007302 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 478801007303 NAD(P) binding site [chemical binding]; other site 478801007304 active site 478801007305 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 478801007306 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 478801007307 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 478801007308 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 478801007309 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 478801007310 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 478801007311 Walker A/P-loop; other site 478801007312 ATP binding site [chemical binding]; other site 478801007313 Q-loop/lid; other site 478801007314 ABC transporter signature motif; other site 478801007315 Walker B; other site 478801007316 D-loop; other site 478801007317 H-loop/switch region; other site 478801007318 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 478801007319 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 478801007320 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 478801007321 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 478801007322 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 478801007323 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 478801007324 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 478801007325 Acyltransferase family; Region: Acyl_transf_3; pfam01757 478801007326 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 478801007327 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 478801007328 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 478801007329 active site 478801007330 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 478801007331 active site 478801007332 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 478801007333 homodimer interface [polypeptide binding]; other site 478801007334 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 478801007335 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 478801007336 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 478801007337 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 478801007338 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 478801007339 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 478801007340 carboxyltransferase (CT) interaction site; other site 478801007341 biotinylation site [posttranslational modification]; other site 478801007342 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 478801007343 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 478801007344 active site 478801007345 NTP binding site [chemical binding]; other site 478801007346 metal binding triad [ion binding]; metal-binding site 478801007347 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 478801007348 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 478801007349 Zn2+ binding site [ion binding]; other site 478801007350 Mg2+ binding site [ion binding]; other site 478801007351 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 478801007352 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 478801007353 active site 478801007354 Ap6A binding site [chemical binding]; other site 478801007355 nudix motif; other site 478801007356 metal binding site [ion binding]; metal-binding site 478801007357 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 478801007358 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 478801007359 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 478801007360 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 478801007361 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 478801007362 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 478801007363 catalytic residues [active] 478801007364 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 478801007365 ParB-like nuclease domain; Region: ParB; smart00470 478801007366 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 478801007367 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 478801007368 P-loop; other site 478801007369 Magnesium ion binding site [ion binding]; other site 478801007370 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 478801007371 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 478801007372 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 478801007373 G-X-X-G motif; other site 478801007374 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 478801007375 RxxxH motif; other site 478801007376 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 478801007377 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 478801007378 Haemolytic domain; Region: Haemolytic; pfam01809 478801007379 Ribonuclease P; Region: Ribonuclease_P; pfam00825