-- dump date 20140619_122320 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1314884000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1314884000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1314884000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1314884000004 Walker A motif; other site 1314884000005 ATP binding site [chemical binding]; other site 1314884000006 Walker B motif; other site 1314884000007 arginine finger; other site 1314884000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1314884000009 DnaA box-binding interface [nucleotide binding]; other site 1314884000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1314884000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1314884000012 putative DNA binding surface [nucleotide binding]; other site 1314884000013 dimer interface [polypeptide binding]; other site 1314884000014 beta-clamp/clamp loader binding surface; other site 1314884000015 beta-clamp/translesion DNA polymerase binding surface; other site 1314884000016 S4 domain; Region: S4_2; pfam13275 1314884000017 recombination protein F; Reviewed; Region: recF; PRK00064 1314884000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1314884000019 Walker A/P-loop; other site 1314884000020 ATP binding site [chemical binding]; other site 1314884000021 Q-loop/lid; other site 1314884000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1314884000023 ABC transporter signature motif; other site 1314884000024 Walker B; other site 1314884000025 D-loop; other site 1314884000026 H-loop/switch region; other site 1314884000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1314884000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1314884000029 Mg2+ binding site [ion binding]; other site 1314884000030 G-X-G motif; other site 1314884000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1314884000032 anchoring element; other site 1314884000033 dimer interface [polypeptide binding]; other site 1314884000034 ATP binding site [chemical binding]; other site 1314884000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1314884000036 active site 1314884000037 putative metal-binding site [ion binding]; other site 1314884000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1314884000039 DNA gyrase subunit A; Validated; Region: PRK05560 1314884000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1314884000041 CAP-like domain; other site 1314884000042 active site 1314884000043 primary dimer interface [polypeptide binding]; other site 1314884000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1314884000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1314884000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1314884000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1314884000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1314884000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1314884000050 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1314884000051 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1314884000052 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1314884000053 dimer interface [polypeptide binding]; other site 1314884000054 ssDNA binding site [nucleotide binding]; other site 1314884000055 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1314884000056 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1314884000057 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1314884000058 DHH family; Region: DHH; pfam01368 1314884000059 DHHA1 domain; Region: DHHA1; pfam02272 1314884000060 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1314884000061 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1314884000062 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1314884000063 replicative DNA helicase; Region: DnaB; TIGR00665 1314884000064 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1314884000065 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1314884000066 Walker A motif; other site 1314884000067 ATP binding site [chemical binding]; other site 1314884000068 Walker B motif; other site 1314884000069 DNA binding loops [nucleotide binding] 1314884000070 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 1314884000071 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1314884000072 membrane-bound complex binding site; other site 1314884000073 hinge residues; other site 1314884000074 EDD domain protein, DegV family; Region: DegV; TIGR00762 1314884000075 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1314884000076 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1314884000077 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1314884000078 nucleotide binding site [chemical binding]; other site 1314884000079 CsbD-like; Region: CsbD; cl17424 1314884000080 Predicted membrane protein [Function unknown]; Region: COG2261 1314884000081 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 1314884000082 Cadmium resistance transporter; Region: Cad; pfam03596 1314884000083 cadmium resistance transporter (or sequestration) family protein; Region: cad; TIGR00779 1314884000084 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1314884000085 dimerization interface [polypeptide binding]; other site 1314884000086 putative DNA binding site [nucleotide binding]; other site 1314884000087 putative Zn2+ binding site [ion binding]; other site 1314884000088 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1314884000089 Plasmid replication protein; Region: Rep_2; pfam01719 1314884000090 RNA helicase; Region: RNA_helicase; pfam00910 1314884000091 Helix-turn-helix domain; Region: HTH_17; pfam12728 1314884000092 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1314884000093 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1314884000094 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1314884000095 Fic/DOC family; Region: Fic; cl00960 1314884000096 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 1314884000097 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 1314884000098 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 1314884000099 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 1314884000100 Peptidase family C69; Region: Peptidase_C69; pfam03577 1314884000101 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1314884000102 Predicted membrane protein [Function unknown]; Region: COG4905 1314884000103 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 1314884000104 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1314884000105 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 1314884000106 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1314884000107 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 1314884000108 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1314884000109 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1314884000110 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 1314884000111 catalytic triad [active] 1314884000112 oxyanion hole [active] 1314884000113 active site 1314884000114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1314884000115 putative substrate translocation pore; other site 1314884000116 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1314884000117 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1314884000118 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1314884000119 Walker A/P-loop; other site 1314884000120 ATP binding site [chemical binding]; other site 1314884000121 Q-loop/lid; other site 1314884000122 ABC transporter signature motif; other site 1314884000123 Walker B; other site 1314884000124 D-loop; other site 1314884000125 H-loop/switch region; other site 1314884000126 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1314884000127 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1314884000128 TM-ABC transporter signature motif; other site 1314884000129 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1314884000130 zinc binding site [ion binding]; other site 1314884000131 putative ligand binding site [chemical binding]; other site 1314884000132 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1314884000133 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1314884000134 motif II; other site 1314884000135 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1314884000136 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1314884000137 G1 box; other site 1314884000138 putative GEF interaction site [polypeptide binding]; other site 1314884000139 GTP/Mg2+ binding site [chemical binding]; other site 1314884000140 Switch I region; other site 1314884000141 G2 box; other site 1314884000142 G3 box; other site 1314884000143 Switch II region; other site 1314884000144 G4 box; other site 1314884000145 G5 box; other site 1314884000146 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1314884000147 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 1314884000148 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1314884000149 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1314884000150 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1314884000151 active site 1314884000152 motif I; other site 1314884000153 motif II; other site 1314884000154 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1314884000155 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1314884000156 putative catalytic site [active] 1314884000157 putative metal binding site [ion binding]; other site 1314884000158 putative phosphate binding site [ion binding]; other site 1314884000159 D-lactate dehydrogenase; Validated; Region: PRK08605 1314884000160 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1314884000161 homodimer interface [polypeptide binding]; other site 1314884000162 ligand binding site [chemical binding]; other site 1314884000163 NAD binding site [chemical binding]; other site 1314884000164 catalytic site [active] 1314884000165 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1314884000166 active site 1314884000167 putative catalytic site [active] 1314884000168 DNA binding site [nucleotide binding] 1314884000169 putative phosphate binding site [ion binding]; other site 1314884000170 metal binding site A [ion binding]; metal-binding site 1314884000171 AP binding site [nucleotide binding]; other site 1314884000172 metal binding site B [ion binding]; metal-binding site 1314884000173 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 1314884000174 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1314884000175 PLD-like domain; Region: PLDc_2; pfam13091 1314884000176 putative homodimer interface [polypeptide binding]; other site 1314884000177 putative active site [active] 1314884000178 catalytic site [active] 1314884000179 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1314884000180 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1314884000181 ATP binding site [chemical binding]; other site 1314884000182 putative Mg++ binding site [ion binding]; other site 1314884000183 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1314884000184 nucleotide binding region [chemical binding]; other site 1314884000185 ATP-binding site [chemical binding]; other site 1314884000186 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1314884000187 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1314884000188 Beta-lactamase; Region: Beta-lactamase; pfam00144 1314884000189 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1314884000190 active site 1314884000191 catalytic residues [active] 1314884000192 metal binding site [ion binding]; metal-binding site 1314884000193 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1314884000194 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1314884000195 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1314884000196 dimerization interface [polypeptide binding]; other site 1314884000197 FMN-binding domain; Region: FMN_bind; pfam04205 1314884000198 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1314884000199 L-aspartate oxidase; Provisional; Region: PRK06175 1314884000200 L-aspartate oxidase; Provisional; Region: PRK06175 1314884000201 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1314884000202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1314884000203 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1314884000204 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 1314884000205 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1314884000206 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1314884000207 putative acyl-acceptor binding pocket; other site 1314884000208 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1314884000209 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1314884000210 Ligand binding site; other site 1314884000211 metal-binding site 1314884000212 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1314884000213 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1314884000214 Ligand binding site; other site 1314884000215 metal-binding site 1314884000216 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1314884000217 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1314884000218 active site 1314884000219 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1314884000220 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1314884000221 putative acyl-acceptor binding pocket; other site 1314884000222 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1314884000223 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1314884000224 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1314884000225 Walker A/P-loop; other site 1314884000226 ATP binding site [chemical binding]; other site 1314884000227 Q-loop/lid; other site 1314884000228 ABC transporter signature motif; other site 1314884000229 Walker B; other site 1314884000230 D-loop; other site 1314884000231 H-loop/switch region; other site 1314884000232 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1314884000233 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1314884000234 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1314884000235 Walker A/P-loop; other site 1314884000236 ATP binding site [chemical binding]; other site 1314884000237 Q-loop/lid; other site 1314884000238 ABC transporter signature motif; other site 1314884000239 Walker B; other site 1314884000240 D-loop; other site 1314884000241 H-loop/switch region; other site 1314884000242 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1314884000243 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1314884000244 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1314884000245 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1314884000246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1314884000247 active site 1314884000248 phosphorylation site [posttranslational modification] 1314884000249 intermolecular recognition site; other site 1314884000250 dimerization interface [polypeptide binding]; other site 1314884000251 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1314884000252 DNA binding site [nucleotide binding] 1314884000253 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1314884000254 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1314884000255 dimerization interface [polypeptide binding]; other site 1314884000256 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1314884000257 putative active site [active] 1314884000258 heme pocket [chemical binding]; other site 1314884000259 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1314884000260 dimer interface [polypeptide binding]; other site 1314884000261 phosphorylation site [posttranslational modification] 1314884000262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1314884000263 ATP binding site [chemical binding]; other site 1314884000264 Mg2+ binding site [ion binding]; other site 1314884000265 G-X-G motif; other site 1314884000266 YycH protein; Region: YycH; pfam07435 1314884000267 YycH protein; Region: YycI; pfam09648 1314884000268 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1314884000269 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1314884000270 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1314884000271 protein binding site [polypeptide binding]; other site 1314884000272 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1314884000273 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1314884000274 non-specific DNA binding site [nucleotide binding]; other site 1314884000275 salt bridge; other site 1314884000276 sequence-specific DNA binding site [nucleotide binding]; other site 1314884000277 CAAX protease self-immunity; Region: Abi; pfam02517 1314884000278 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1314884000279 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1314884000280 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1314884000281 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1314884000282 Walker A/P-loop; other site 1314884000283 ATP binding site [chemical binding]; other site 1314884000284 Q-loop/lid; other site 1314884000285 ABC transporter signature motif; other site 1314884000286 Walker B; other site 1314884000287 D-loop; other site 1314884000288 H-loop/switch region; other site 1314884000289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1314884000290 Walker A/P-loop; other site 1314884000291 ATP binding site [chemical binding]; other site 1314884000292 ABC transporter; Region: ABC_tran; pfam00005 1314884000293 Q-loop/lid; other site 1314884000294 ABC transporter signature motif; other site 1314884000295 Walker B; other site 1314884000296 D-loop; other site 1314884000297 H-loop/switch region; other site 1314884000298 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1314884000299 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1314884000300 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1314884000301 heat shock protein HtpX; Provisional; Region: PRK04897 1314884000302 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1314884000303 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1314884000304 transmembrane helices; other site 1314884000305 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1314884000306 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 1314884000307 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1314884000308 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1314884000309 putative active site [active] 1314884000310 catalytic site [active] 1314884000311 putative metal binding site [ion binding]; other site 1314884000312 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1314884000313 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1314884000314 DXD motif; other site 1314884000315 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1314884000316 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1314884000317 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1314884000318 Zn2+ binding site [ion binding]; other site 1314884000319 Mg2+ binding site [ion binding]; other site 1314884000320 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1314884000321 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1314884000322 active site 1314884000323 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 1314884000324 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1314884000325 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1314884000326 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1314884000327 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1314884000328 Walker A/P-loop; other site 1314884000329 ATP binding site [chemical binding]; other site 1314884000330 Q-loop/lid; other site 1314884000331 ABC transporter signature motif; other site 1314884000332 Walker B; other site 1314884000333 D-loop; other site 1314884000334 H-loop/switch region; other site 1314884000335 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1314884000336 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1314884000337 substrate binding pocket [chemical binding]; other site 1314884000338 membrane-bound complex binding site; other site 1314884000339 hinge residues; other site 1314884000340 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1314884000341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1314884000342 dimer interface [polypeptide binding]; other site 1314884000343 conserved gate region; other site 1314884000344 putative PBP binding loops; other site 1314884000345 ABC-ATPase subunit interface; other site 1314884000346 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1314884000347 active site 1314884000348 DNA binding site [nucleotide binding] 1314884000349 Protein of unknown function, DUF488; Region: DUF488; cl01246 1314884000350 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1314884000351 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1314884000352 NAD-dependent deacetylase; Provisional; Region: PRK00481 1314884000353 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1314884000354 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1314884000355 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1314884000356 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1314884000357 putative active site [active] 1314884000358 catalytic site [active] 1314884000359 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1314884000360 putative active site [active] 1314884000361 catalytic site [active] 1314884000362 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1314884000363 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 1314884000364 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1314884000365 RNA/DNA hybrid binding site [nucleotide binding]; other site 1314884000366 active site 1314884000367 Predicted secreted protein [Function unknown]; Region: COG4086 1314884000368 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1314884000369 putative glycosyl transferase; Provisional; Region: PRK10073 1314884000370 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1314884000371 active site 1314884000372 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1314884000373 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1314884000374 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1314884000375 non-specific DNA binding site [nucleotide binding]; other site 1314884000376 salt bridge; other site 1314884000377 sequence-specific DNA binding site [nucleotide binding]; other site 1314884000378 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1314884000379 Helix-turn-helix domain; Region: HTH_28; pfam13518 1314884000380 HTH-like domain; Region: HTH_21; pfam13276 1314884000381 Integrase core domain; Region: rve; pfam00665 1314884000382 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1314884000383 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1314884000384 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1314884000385 active site 1314884000386 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1314884000387 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1314884000388 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1314884000389 substrate binding pocket [chemical binding]; other site 1314884000390 membrane-bound complex binding site; other site 1314884000391 hinge residues; other site 1314884000392 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1314884000393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1314884000394 dimer interface [polypeptide binding]; other site 1314884000395 conserved gate region; other site 1314884000396 putative PBP binding loops; other site 1314884000397 ABC-ATPase subunit interface; other site 1314884000398 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1314884000399 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1314884000400 Walker A/P-loop; other site 1314884000401 ATP binding site [chemical binding]; other site 1314884000402 Q-loop/lid; other site 1314884000403 ABC transporter signature motif; other site 1314884000404 Walker B; other site 1314884000405 D-loop; other site 1314884000406 H-loop/switch region; other site 1314884000407 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1314884000408 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1314884000409 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1314884000410 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1314884000411 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1314884000412 DNA binding residues [nucleotide binding] 1314884000413 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 1314884000414 YibE/F-like protein; Region: YibE_F; pfam07907 1314884000415 YibE/F-like protein; Region: YibE_F; pfam07907 1314884000416 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1314884000417 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1314884000418 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1314884000419 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1314884000420 active site 1314884000421 catalytic site [active] 1314884000422 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1314884000423 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1314884000424 Interdomain contacts; other site 1314884000425 Cytokine receptor motif; other site 1314884000426 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1314884000427 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1314884000428 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1314884000429 active site 1314884000430 dimer interface [polypeptide binding]; other site 1314884000431 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1314884000432 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1314884000433 active site 1314884000434 phosphorylation site [posttranslational modification] 1314884000435 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1314884000436 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1314884000437 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1314884000438 Ligand Binding Site [chemical binding]; other site 1314884000439 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1314884000440 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1314884000441 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1314884000442 membrane-bound complex binding site; other site 1314884000443 hinge residues; other site 1314884000444 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1314884000445 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1314884000446 Walker A/P-loop; other site 1314884000447 ATP binding site [chemical binding]; other site 1314884000448 Q-loop/lid; other site 1314884000449 ABC transporter signature motif; other site 1314884000450 Walker B; other site 1314884000451 D-loop; other site 1314884000452 H-loop/switch region; other site 1314884000453 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1314884000454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1314884000455 dimer interface [polypeptide binding]; other site 1314884000456 conserved gate region; other site 1314884000457 putative PBP binding loops; other site 1314884000458 ABC-ATPase subunit interface; other site 1314884000459 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1314884000460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1314884000461 dimer interface [polypeptide binding]; other site 1314884000462 conserved gate region; other site 1314884000463 putative PBP binding loops; other site 1314884000464 ABC-ATPase subunit interface; other site 1314884000465 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1314884000466 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1314884000467 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1314884000468 active site 1314884000469 dimer interface [polypeptide binding]; other site 1314884000470 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1314884000471 Ligand Binding Site [chemical binding]; other site 1314884000472 Molecular Tunnel; other site 1314884000473 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1314884000474 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 1314884000475 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1314884000476 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1314884000477 ATP cone domain; Region: ATP-cone; pfam03477 1314884000478 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1314884000479 effector binding site; other site 1314884000480 active site 1314884000481 Zn binding site [ion binding]; other site 1314884000482 glycine loop; other site 1314884000483 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 1314884000484 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1314884000485 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1314884000486 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 1314884000487 Uncharacterized conserved protein [Function unknown]; Region: COG2461 1314884000488 Family of unknown function (DUF438); Region: DUF438; pfam04282 1314884000489 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1314884000490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1314884000491 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1314884000492 putative substrate translocation pore; other site 1314884000493 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1314884000494 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1314884000495 active site 1314884000496 Zn binding site [ion binding]; other site 1314884000497 K+ potassium transporter; Region: K_trans; pfam02705 1314884000498 Bacterial surface layer protein; Region: SLAP; pfam03217 1314884000499 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1314884000500 putative glycosyltransferase, exosortase G-associated; Region: glyc2_xrt_Gpos1; TIGR03111 1314884000501 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1314884000502 DXD motif; other site 1314884000503 exosortase family protein XrtG; Region: exosort_Gpos; TIGR03110 1314884000504 Bacterial surface layer protein; Region: SLAP; pfam03217 1314884000505 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1314884000506 Bacterial surface layer protein; Region: SLAP; pfam03217 1314884000507 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1314884000508 amidase catalytic site [active] 1314884000509 Zn binding residues [ion binding]; other site 1314884000510 substrate binding site [chemical binding]; other site 1314884000511 Bacterial surface layer protein; Region: SLAP; pfam03217 1314884000512 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1314884000513 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1314884000514 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1314884000515 TrkA-N domain; Region: TrkA_N; pfam02254 1314884000516 TrkA-C domain; Region: TrkA_C; pfam02080 1314884000517 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1314884000518 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1314884000519 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1314884000520 catalytic core [active] 1314884000521 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1314884000522 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1314884000523 putative substrate binding pocket [chemical binding]; other site 1314884000524 AC domain interface; other site 1314884000525 catalytic triad [active] 1314884000526 AB domain interface; other site 1314884000527 interchain disulfide; other site 1314884000528 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1314884000529 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1314884000530 membrane protein; Provisional; Region: PRK14411 1314884000531 Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060 1314884000532 Sulfatase; Region: Sulfatase; cl17466 1314884000533 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1314884000534 Interdomain contacts; other site 1314884000535 Cytokine receptor motif; other site 1314884000536 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1314884000537 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1314884000538 active site 1314884000539 HIGH motif; other site 1314884000540 dimer interface [polypeptide binding]; other site 1314884000541 KMSKS motif; other site 1314884000542 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1314884000543 RNA binding surface [nucleotide binding]; other site 1314884000544 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1314884000545 trimer interface [polypeptide binding]; other site 1314884000546 active site 1314884000547 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1314884000548 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1314884000549 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1314884000550 peptide binding site [polypeptide binding]; other site 1314884000551 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1314884000552 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1314884000553 peptide binding site [polypeptide binding]; other site 1314884000554 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 1314884000555 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1314884000556 active site 1314884000557 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1314884000558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1314884000559 dimer interface [polypeptide binding]; other site 1314884000560 conserved gate region; other site 1314884000561 putative PBP binding loops; other site 1314884000562 ABC-ATPase subunit interface; other site 1314884000563 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1314884000564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1314884000565 dimer interface [polypeptide binding]; other site 1314884000566 conserved gate region; other site 1314884000567 putative PBP binding loops; other site 1314884000568 ABC-ATPase subunit interface; other site 1314884000569 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1314884000570 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1314884000571 Walker A/P-loop; other site 1314884000572 ATP binding site [chemical binding]; other site 1314884000573 Q-loop/lid; other site 1314884000574 ABC transporter signature motif; other site 1314884000575 Walker B; other site 1314884000576 D-loop; other site 1314884000577 H-loop/switch region; other site 1314884000578 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1314884000579 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1314884000580 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1314884000581 Walker A/P-loop; other site 1314884000582 ATP binding site [chemical binding]; other site 1314884000583 Q-loop/lid; other site 1314884000584 ABC transporter signature motif; other site 1314884000585 Walker B; other site 1314884000586 D-loop; other site 1314884000587 H-loop/switch region; other site 1314884000588 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1314884000589 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1314884000590 trimer interface [polypeptide binding]; other site 1314884000591 active site 1314884000592 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 1314884000593 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1314884000594 putative dimer interface [polypeptide binding]; other site 1314884000595 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1314884000596 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1314884000597 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1314884000598 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1314884000599 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1314884000600 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1314884000601 active site 1314884000602 HIGH motif; other site 1314884000603 dimer interface [polypeptide binding]; other site 1314884000604 KMSKS motif; other site 1314884000605 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1314884000606 catalytic motif [active] 1314884000607 Zn binding site [ion binding]; other site 1314884000608 Repair protein; Region: Repair_PSII; cl01535 1314884000609 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1314884000610 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1314884000611 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1314884000612 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1314884000613 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1314884000614 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1314884000615 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1314884000616 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1314884000617 active site 1314884000618 HIGH motif; other site 1314884000619 KMSKS motif; other site 1314884000620 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1314884000621 tRNA binding surface [nucleotide binding]; other site 1314884000622 anticodon binding site; other site 1314884000623 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1314884000624 dimer interface [polypeptide binding]; other site 1314884000625 putative tRNA-binding site [nucleotide binding]; other site 1314884000626 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1314884000627 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1314884000628 active site 1314884000629 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1314884000630 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1314884000631 putative active site [active] 1314884000632 putative metal binding site [ion binding]; other site 1314884000633 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1314884000634 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1314884000635 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1314884000636 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1314884000637 pur operon repressor; Provisional; Region: PRK09213 1314884000638 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1314884000639 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1314884000640 active site 1314884000641 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1314884000642 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1314884000643 Substrate binding site; other site 1314884000644 Mg++ binding site; other site 1314884000645 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1314884000646 active site 1314884000647 substrate binding site [chemical binding]; other site 1314884000648 CoA binding site [chemical binding]; other site 1314884000649 Bacterial surface layer protein; Region: SLAP; pfam03217 1314884000650 Bacterial surface layer protein; Region: SLAP; pfam03217 1314884000651 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1314884000652 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1314884000653 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1314884000654 active site 1314884000655 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1314884000656 beta-galactosidase; Region: BGL; TIGR03356 1314884000657 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1314884000658 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1314884000659 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1314884000660 putative active site [active] 1314884000661 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1314884000662 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1314884000663 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1314884000664 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1314884000665 nucleotide binding site [chemical binding]; other site 1314884000666 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1314884000667 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1314884000668 Zn2+ binding site [ion binding]; other site 1314884000669 Mg2+ binding site [ion binding]; other site 1314884000670 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1314884000671 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1314884000672 CTP synthetase; Validated; Region: pyrG; PRK05380 1314884000673 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1314884000674 Catalytic site [active] 1314884000675 active site 1314884000676 UTP binding site [chemical binding]; other site 1314884000677 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1314884000678 active site 1314884000679 putative oxyanion hole; other site 1314884000680 catalytic triad [active] 1314884000681 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1314884000682 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1314884000683 hinge; other site 1314884000684 active site 1314884000685 Peptidase family C69; Region: Peptidase_C69; cl17793 1314884000686 Peptidase family C69; Region: Peptidase_C69; cl17793 1314884000687 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1314884000688 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1314884000689 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1314884000690 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1314884000691 xanthine permease; Region: pbuX; TIGR03173 1314884000692 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1314884000693 active site 1314884000694 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1314884000695 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1314884000696 non-specific DNA binding site [nucleotide binding]; other site 1314884000697 salt bridge; other site 1314884000698 sequence-specific DNA binding site [nucleotide binding]; other site 1314884000699 GMP synthase; Reviewed; Region: guaA; PRK00074 1314884000700 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1314884000701 AMP/PPi binding site [chemical binding]; other site 1314884000702 candidate oxyanion hole; other site 1314884000703 catalytic triad [active] 1314884000704 potential glutamine specificity residues [chemical binding]; other site 1314884000705 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1314884000706 ATP Binding subdomain [chemical binding]; other site 1314884000707 Ligand Binding sites [chemical binding]; other site 1314884000708 Dimerization subdomain; other site 1314884000709 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1314884000710 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1314884000711 Walker A/P-loop; other site 1314884000712 ATP binding site [chemical binding]; other site 1314884000713 Q-loop/lid; other site 1314884000714 ABC transporter signature motif; other site 1314884000715 Walker B; other site 1314884000716 D-loop; other site 1314884000717 H-loop/switch region; other site 1314884000718 LytTr DNA-binding domain; Region: LytTR; smart00850 1314884000719 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1314884000720 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1314884000721 Coenzyme A binding pocket [chemical binding]; other site 1314884000722 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1314884000723 B3/4 domain; Region: B3_4; pfam03483 1314884000724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1314884000725 putative substrate translocation pore; other site 1314884000726 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1314884000727 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1314884000728 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1314884000729 DNA binding site [nucleotide binding] 1314884000730 active site 1314884000731 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1314884000732 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1314884000733 dimer interface [polypeptide binding]; other site 1314884000734 active site 1314884000735 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1314884000736 folate binding site [chemical binding]; other site 1314884000737 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1314884000738 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1314884000739 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1314884000740 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1314884000741 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1314884000742 Ca binding site [ion binding]; other site 1314884000743 active site 1314884000744 catalytic site [active] 1314884000745 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1314884000746 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1314884000747 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1314884000748 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1314884000749 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1314884000750 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1314884000751 ATP binding site [chemical binding]; other site 1314884000752 Mg++ binding site [ion binding]; other site 1314884000753 motif III; other site 1314884000754 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1314884000755 nucleotide binding region [chemical binding]; other site 1314884000756 ATP-binding site [chemical binding]; other site 1314884000757 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1314884000758 alanine racemase; Reviewed; Region: alr; PRK00053 1314884000759 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1314884000760 active site 1314884000761 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1314884000762 dimer interface [polypeptide binding]; other site 1314884000763 substrate binding site [chemical binding]; other site 1314884000764 catalytic residues [active] 1314884000765 FOG: CBS domain [General function prediction only]; Region: COG0517 1314884000766 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1314884000767 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1314884000768 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1314884000769 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1314884000770 NAD binding site [chemical binding]; other site 1314884000771 dimer interface [polypeptide binding]; other site 1314884000772 substrate binding site [chemical binding]; other site 1314884000773 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1314884000774 putative active site [active] 1314884000775 catalytic residue [active] 1314884000776 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1314884000777 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1314884000778 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1314884000779 ATP binding site [chemical binding]; other site 1314884000780 putative Mg++ binding site [ion binding]; other site 1314884000781 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1314884000782 nucleotide binding region [chemical binding]; other site 1314884000783 ATP-binding site [chemical binding]; other site 1314884000784 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1314884000785 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1314884000786 RNA binding surface [nucleotide binding]; other site 1314884000787 Septum formation initiator; Region: DivIC; pfam04977 1314884000788 S1 RNA binding domain; Region: S1; pfam00575 1314884000789 RNA binding site [nucleotide binding]; other site 1314884000790 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1314884000791 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1314884000792 Ligand Binding Site [chemical binding]; other site 1314884000793 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1314884000794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1314884000795 Walker A motif; other site 1314884000796 ATP binding site [chemical binding]; other site 1314884000797 Walker B motif; other site 1314884000798 arginine finger; other site 1314884000799 Peptidase family M41; Region: Peptidase_M41; pfam01434 1314884000800 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1314884000801 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1314884000802 dimerization interface [polypeptide binding]; other site 1314884000803 domain crossover interface; other site 1314884000804 redox-dependent activation switch; other site 1314884000805 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1314884000806 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1314884000807 FMN binding site [chemical binding]; other site 1314884000808 active site 1314884000809 catalytic residues [active] 1314884000810 substrate binding site [chemical binding]; other site 1314884000811 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1314884000812 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1314884000813 dimer interface [polypeptide binding]; other site 1314884000814 putative anticodon binding site; other site 1314884000815 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1314884000816 motif 1; other site 1314884000817 active site 1314884000818 motif 2; other site 1314884000819 motif 3; other site 1314884000820 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1314884000821 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1314884000822 Clp amino terminal domain; Region: Clp_N; pfam02861 1314884000823 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1314884000824 Walker A motif; other site 1314884000825 ATP binding site [chemical binding]; other site 1314884000826 Walker B motif; other site 1314884000827 arginine finger; other site 1314884000828 UvrB/uvrC motif; Region: UVR; pfam02151 1314884000829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1314884000830 Walker A motif; other site 1314884000831 ATP binding site [chemical binding]; other site 1314884000832 Walker B motif; other site 1314884000833 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1314884000834 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1314884000835 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1314884000836 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1314884000837 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1314884000838 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1314884000839 RPB1 interaction site [polypeptide binding]; other site 1314884000840 RPB10 interaction site [polypeptide binding]; other site 1314884000841 RPB11 interaction site [polypeptide binding]; other site 1314884000842 RPB3 interaction site [polypeptide binding]; other site 1314884000843 RPB12 interaction site [polypeptide binding]; other site 1314884000844 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1314884000845 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1314884000846 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1314884000847 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1314884000848 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1314884000849 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1314884000850 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1314884000851 G-loop; other site 1314884000852 DNA binding site [nucleotide binding] 1314884000853 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1314884000854 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1314884000855 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1314884000856 S17 interaction site [polypeptide binding]; other site 1314884000857 S8 interaction site; other site 1314884000858 16S rRNA interaction site [nucleotide binding]; other site 1314884000859 streptomycin interaction site [chemical binding]; other site 1314884000860 23S rRNA interaction site [nucleotide binding]; other site 1314884000861 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1314884000862 30S ribosomal protein S7; Validated; Region: PRK05302 1314884000863 elongation factor G; Reviewed; Region: PRK12739 1314884000864 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1314884000865 G1 box; other site 1314884000866 putative GEF interaction site [polypeptide binding]; other site 1314884000867 GTP/Mg2+ binding site [chemical binding]; other site 1314884000868 Switch I region; other site 1314884000869 G2 box; other site 1314884000870 G3 box; other site 1314884000871 Switch II region; other site 1314884000872 G4 box; other site 1314884000873 G5 box; other site 1314884000874 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1314884000875 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1314884000876 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1314884000877 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1314884000878 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1314884000879 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1314884000880 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1314884000881 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1314884000882 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1314884000883 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1314884000884 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1314884000885 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1314884000886 putative translocon binding site; other site 1314884000887 protein-rRNA interface [nucleotide binding]; other site 1314884000888 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1314884000889 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1314884000890 G-X-X-G motif; other site 1314884000891 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1314884000892 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1314884000893 23S rRNA interface [nucleotide binding]; other site 1314884000894 5S rRNA interface [nucleotide binding]; other site 1314884000895 putative antibiotic binding site [chemical binding]; other site 1314884000896 L25 interface [polypeptide binding]; other site 1314884000897 L27 interface [polypeptide binding]; other site 1314884000898 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1314884000899 23S rRNA interface [nucleotide binding]; other site 1314884000900 putative translocon interaction site; other site 1314884000901 signal recognition particle (SRP54) interaction site; other site 1314884000902 L23 interface [polypeptide binding]; other site 1314884000903 trigger factor interaction site; other site 1314884000904 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1314884000905 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1314884000906 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1314884000907 RNA binding site [nucleotide binding]; other site 1314884000908 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1314884000909 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1314884000910 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1314884000911 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1314884000912 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1314884000913 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1314884000914 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1314884000915 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1314884000916 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1314884000917 23S rRNA interface [nucleotide binding]; other site 1314884000918 L21e interface [polypeptide binding]; other site 1314884000919 5S rRNA interface [nucleotide binding]; other site 1314884000920 L27 interface [polypeptide binding]; other site 1314884000921 L5 interface [polypeptide binding]; other site 1314884000922 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 1314884000923 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1314884000924 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1314884000925 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1314884000926 23S rRNA binding site [nucleotide binding]; other site 1314884000927 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1314884000928 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1314884000929 SecY translocase; Region: SecY; pfam00344 1314884000930 adenylate kinase; Reviewed; Region: adk; PRK00279 1314884000931 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1314884000932 AMP-binding site [chemical binding]; other site 1314884000933 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1314884000934 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1314884000935 rRNA binding site [nucleotide binding]; other site 1314884000936 predicted 30S ribosome binding site; other site 1314884000937 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1314884000938 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1314884000939 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1314884000940 30S ribosomal protein S11; Validated; Region: PRK05309 1314884000941 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1314884000942 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1314884000943 alphaNTD homodimer interface [polypeptide binding]; other site 1314884000944 alphaNTD - beta interaction site [polypeptide binding]; other site 1314884000945 alphaNTD - beta' interaction site [polypeptide binding]; other site 1314884000946 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1314884000947 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1314884000948 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13640 1314884000949 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1314884000950 Walker A/P-loop; other site 1314884000951 ATP binding site [chemical binding]; other site 1314884000952 Q-loop/lid; other site 1314884000953 ABC transporter signature motif; other site 1314884000954 Walker B; other site 1314884000955 D-loop; other site 1314884000956 H-loop/switch region; other site 1314884000957 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13641 1314884000958 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1314884000959 Walker A/P-loop; other site 1314884000960 ATP binding site [chemical binding]; other site 1314884000961 Q-loop/lid; other site 1314884000962 ABC transporter signature motif; other site 1314884000963 Walker B; other site 1314884000964 D-loop; other site 1314884000965 H-loop/switch region; other site 1314884000966 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1314884000967 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1314884000968 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1314884000969 dimerization interface 3.5A [polypeptide binding]; other site 1314884000970 active site 1314884000971 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1314884000972 23S rRNA interface [nucleotide binding]; other site 1314884000973 L3 interface [polypeptide binding]; other site 1314884000974 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1314884000975 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1314884000976 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1314884000977 active site 1314884000978 DNA binding site [nucleotide binding] 1314884000979 Int/Topo IB signature motif; other site 1314884000980 Plasmid replication protein; Region: Rep_2; pfam01719 1314884000981 RNA helicase; Region: RNA_helicase; pfam00910 1314884000982 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1314884000983 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 1314884000984 YjcQ protein; Region: YjcQ; pfam09639 1314884000985 DJ-1 family protein; Region: not_thiJ; TIGR01383 1314884000986 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1314884000987 conserved cys residue [active] 1314884000988 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1314884000989 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1314884000990 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1314884000991 hypothetical protein; Provisional; Region: PRK10621 1314884000992 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1314884000993 catalytic core [active] 1314884000994 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1314884000995 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1314884000996 Phosphoglycerate mutase family; Region: PGAM; smart00855 1314884000997 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1314884000998 AAA domain; Region: AAA_33; pfam13671 1314884000999 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1314884001000 trimer interface [polypeptide binding]; other site 1314884001001 active site 1314884001002 G bulge; other site 1314884001003 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1314884001004 trimer interface [polypeptide binding]; other site 1314884001005 active site 1314884001006 DNA repair protein RadA; Provisional; Region: PRK11823 1314884001007 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1314884001008 Walker A motif/ATP binding site; other site 1314884001009 ATP binding site [chemical binding]; other site 1314884001010 Walker B motif; other site 1314884001011 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1314884001012 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1314884001013 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1314884001014 active site 1314884001015 HIGH motif; other site 1314884001016 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1314884001017 active site 1314884001018 KMSKS motif; other site 1314884001019 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1314884001020 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1314884001021 active site 1314884001022 HIGH motif; other site 1314884001023 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1314884001024 KMSKS motif; other site 1314884001025 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1314884001026 tRNA binding surface [nucleotide binding]; other site 1314884001027 anticodon binding site; other site 1314884001028 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1314884001029 active site 1314884001030 metal binding site [ion binding]; metal-binding site 1314884001031 dimerization interface [polypeptide binding]; other site 1314884001032 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1314884001033 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1314884001034 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1314884001035 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1314884001036 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1314884001037 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1314884001038 active site 1314884001039 catalytic site [active] 1314884001040 metal binding site [ion binding]; metal-binding site 1314884001041 carbohydrate binding site [chemical binding]; other site 1314884001042 N- and C-terminal domain interface [polypeptide binding]; other site 1314884001043 ATP binding site [chemical binding]; other site 1314884001044 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1314884001045 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 1314884001046 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1314884001047 TPP-binding site; other site 1314884001048 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1314884001049 PYR/PP interface [polypeptide binding]; other site 1314884001050 dimer interface [polypeptide binding]; other site 1314884001051 TPP binding site [chemical binding]; other site 1314884001052 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1314884001053 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1314884001054 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1314884001055 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1314884001056 putative homodimer interface [polypeptide binding]; other site 1314884001057 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1314884001058 heterodimer interface [polypeptide binding]; other site 1314884001059 homodimer interface [polypeptide binding]; other site 1314884001060 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1314884001061 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1314884001062 23S rRNA interface [nucleotide binding]; other site 1314884001063 L7/L12 interface [polypeptide binding]; other site 1314884001064 putative thiostrepton binding site; other site 1314884001065 L25 interface [polypeptide binding]; other site 1314884001066 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1314884001067 mRNA/rRNA interface [nucleotide binding]; other site 1314884001068 PBP superfamily domain; Region: PBP_like_2; cl17296 1314884001069 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1314884001070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1314884001071 dimer interface [polypeptide binding]; other site 1314884001072 conserved gate region; other site 1314884001073 putative PBP binding loops; other site 1314884001074 ABC-ATPase subunit interface; other site 1314884001075 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1314884001076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1314884001077 dimer interface [polypeptide binding]; other site 1314884001078 conserved gate region; other site 1314884001079 putative PBP binding loops; other site 1314884001080 ABC-ATPase subunit interface; other site 1314884001081 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 1314884001082 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1314884001083 Walker A/P-loop; other site 1314884001084 ATP binding site [chemical binding]; other site 1314884001085 Q-loop/lid; other site 1314884001086 ABC transporter signature motif; other site 1314884001087 Walker B; other site 1314884001088 D-loop; other site 1314884001089 H-loop/switch region; other site 1314884001090 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14251 1314884001091 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1314884001092 Walker A/P-loop; other site 1314884001093 ATP binding site [chemical binding]; other site 1314884001094 Q-loop/lid; other site 1314884001095 ABC transporter signature motif; other site 1314884001096 Walker B; other site 1314884001097 D-loop; other site 1314884001098 H-loop/switch region; other site 1314884001099 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1314884001100 PhoU domain; Region: PhoU; pfam01895 1314884001101 PhoU domain; Region: PhoU; pfam01895 1314884001102 Membrane transport protein; Region: Mem_trans; cl09117 1314884001103 Membrane transport protein; Region: Mem_trans; cl09117 1314884001104 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1314884001105 23S rRNA interface [nucleotide binding]; other site 1314884001106 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1314884001107 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1314884001108 core dimer interface [polypeptide binding]; other site 1314884001109 peripheral dimer interface [polypeptide binding]; other site 1314884001110 L10 interface [polypeptide binding]; other site 1314884001111 L11 interface [polypeptide binding]; other site 1314884001112 putative EF-Tu interaction site [polypeptide binding]; other site 1314884001113 putative EF-G interaction site [polypeptide binding]; other site 1314884001114 Ion channel; Region: Ion_trans_2; pfam07885 1314884001115 Centromere protein H (CENP-H); Region: CENP-H; pfam05837 1314884001116 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1314884001117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1314884001118 S-adenosylmethionine binding site [chemical binding]; other site 1314884001119 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1314884001120 nucleoside/Zn binding site; other site 1314884001121 dimer interface [polypeptide binding]; other site 1314884001122 catalytic motif [active] 1314884001123 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1314884001124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1314884001125 Walker A motif; other site 1314884001126 ATP binding site [chemical binding]; other site 1314884001127 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1314884001128 Walker B motif; other site 1314884001129 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1314884001130 Probable transposase; Region: OrfB_IS605; pfam01385 1314884001131 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1314884001132 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1314884001133 recombination protein RecR; Reviewed; Region: recR; PRK00076 1314884001134 RecR protein; Region: RecR; pfam02132 1314884001135 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1314884001136 putative active site [active] 1314884001137 putative metal-binding site [ion binding]; other site 1314884001138 tetramer interface [polypeptide binding]; other site 1314884001139 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1314884001140 thymidylate kinase; Validated; Region: tmk; PRK00698 1314884001141 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1314884001142 TMP-binding site; other site 1314884001143 ATP-binding site [chemical binding]; other site 1314884001144 Protein of unknown function (DUF970); Region: DUF970; cl17525 1314884001145 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 1314884001146 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1314884001147 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1314884001148 Predicted methyltransferases [General function prediction only]; Region: COG0313 1314884001149 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1314884001150 putative SAM binding site [chemical binding]; other site 1314884001151 putative homodimer interface [polypeptide binding]; other site 1314884001152 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 1314884001153 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1314884001154 active site 1314884001155 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1314884001156 active site 2 [active] 1314884001157 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1314884001158 Glycoprotease family; Region: Peptidase_M22; pfam00814 1314884001159 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1314884001160 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1314884001161 Coenzyme A binding pocket [chemical binding]; other site 1314884001162 UGMP family protein; Validated; Region: PRK09604 1314884001163 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1314884001164 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1314884001165 intersubunit interface [polypeptide binding]; other site 1314884001166 active site 1314884001167 catalytic residue [active] 1314884001168 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1314884001169 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1314884001170 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1314884001171 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1314884001172 DNA-binding site [nucleotide binding]; DNA binding site 1314884001173 UTRA domain; Region: UTRA; pfam07702 1314884001174 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1314884001175 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1314884001176 formyl-CoA transferase; Region: oxalate_frc; TIGR03253 1314884001177 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1314884001178 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1314884001179 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1314884001180 PYR/PP interface [polypeptide binding]; other site 1314884001181 dimer interface [polypeptide binding]; other site 1314884001182 TPP binding site [chemical binding]; other site 1314884001183 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1314884001184 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1314884001185 TPP-binding site; other site 1314884001186 dimer interface [polypeptide binding]; other site 1314884001187 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1314884001188 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1314884001189 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1314884001190 ABC transporter; Region: ABC_tran_2; pfam12848 1314884001191 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1314884001192 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1314884001193 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1314884001194 CoA binding domain; Region: CoA_binding; pfam02629 1314884001195 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1314884001196 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1314884001197 DNA binding site [nucleotide binding] 1314884001198 domain linker motif; other site 1314884001199 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1314884001200 dimerization interface [polypeptide binding]; other site 1314884001201 ligand binding site [chemical binding]; other site 1314884001202 sodium binding site [ion binding]; other site 1314884001203 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1314884001204 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1314884001205 substrate binding [chemical binding]; other site 1314884001206 active site 1314884001207 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1314884001208 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1314884001209 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1314884001210 active site turn [active] 1314884001211 phosphorylation site [posttranslational modification] 1314884001212 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1314884001213 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1314884001214 HPr interaction site; other site 1314884001215 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1314884001216 active site 1314884001217 phosphorylation site [posttranslational modification] 1314884001218 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1314884001219 LytTr DNA-binding domain; Region: LytTR; smart00850 1314884001220 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 1314884001221 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1314884001222 oligomerisation interface [polypeptide binding]; other site 1314884001223 mobile loop; other site 1314884001224 roof hairpin; other site 1314884001225 chaperonin GroL; Region: GroEL; TIGR02348 1314884001226 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1314884001227 ring oligomerisation interface [polypeptide binding]; other site 1314884001228 ATP/Mg binding site [chemical binding]; other site 1314884001229 stacking interactions; other site 1314884001230 hinge regions; other site 1314884001231 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1314884001232 MutS domain I; Region: MutS_I; pfam01624 1314884001233 MutS domain II; Region: MutS_II; pfam05188 1314884001234 MutS domain III; Region: MutS_III; pfam05192 1314884001235 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1314884001236 Walker A/P-loop; other site 1314884001237 ATP binding site [chemical binding]; other site 1314884001238 Q-loop/lid; other site 1314884001239 ABC transporter signature motif; other site 1314884001240 Walker B; other site 1314884001241 D-loop; other site 1314884001242 H-loop/switch region; other site 1314884001243 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1314884001244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1314884001245 ATP binding site [chemical binding]; other site 1314884001246 Mg2+ binding site [ion binding]; other site 1314884001247 G-X-G motif; other site 1314884001248 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1314884001249 ATP binding site [chemical binding]; other site 1314884001250 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1314884001251 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1314884001252 RuvA N terminal domain; Region: RuvA_N; pfam01330 1314884001253 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1314884001254 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1314884001255 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1314884001256 Walker A motif; other site 1314884001257 ATP binding site [chemical binding]; other site 1314884001258 Walker B motif; other site 1314884001259 arginine finger; other site 1314884001260 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1314884001261 Preprotein translocase subunit; Region: YajC; pfam02699 1314884001262 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1314884001263 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1314884001264 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1314884001265 DNA polymerase IV; Validated; Region: PRK02406 1314884001266 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1314884001267 active site 1314884001268 DNA binding site [nucleotide binding] 1314884001269 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1314884001270 DHH family; Region: DHH; pfam01368 1314884001271 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1314884001272 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1314884001273 ATP binding site [chemical binding]; other site 1314884001274 putative Mg++ binding site [ion binding]; other site 1314884001275 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1314884001276 nucleotide binding region [chemical binding]; other site 1314884001277 ATP-binding site [chemical binding]; other site 1314884001278 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1314884001279 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1314884001280 motif 1; other site 1314884001281 active site 1314884001282 motif 2; other site 1314884001283 motif 3; other site 1314884001284 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1314884001285 DHHA1 domain; Region: DHHA1; pfam02272 1314884001286 hypothetical protein; Provisional; Region: PRK05473 1314884001287 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1314884001288 hypothetical protein; Provisional; Region: PRK13678 1314884001289 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1314884001290 MutS domain III; Region: MutS_III; pfam05192 1314884001291 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1314884001292 Walker A/P-loop; other site 1314884001293 ATP binding site [chemical binding]; other site 1314884001294 Q-loop/lid; other site 1314884001295 ABC transporter signature motif; other site 1314884001296 Walker B; other site 1314884001297 D-loop; other site 1314884001298 H-loop/switch region; other site 1314884001299 Smr domain; Region: Smr; pfam01713 1314884001300 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1314884001301 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1314884001302 catalytic residues [active] 1314884001303 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1314884001304 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1314884001305 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1314884001306 glutamate racemase; Provisional; Region: PRK00865 1314884001307 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1314884001308 active site 1314884001309 dimerization interface [polypeptide binding]; other site 1314884001310 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 1314884001311 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1314884001312 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1314884001313 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1314884001314 active site 1314884001315 catabolite control protein A; Region: ccpA; TIGR01481 1314884001316 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1314884001317 DNA binding site [nucleotide binding] 1314884001318 domain linker motif; other site 1314884001319 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1314884001320 dimerization interface [polypeptide binding]; other site 1314884001321 effector binding site; other site 1314884001322 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1314884001323 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 1314884001324 active site 1314884001325 catalytic site [active] 1314884001326 metal binding site [ion binding]; metal-binding site 1314884001327 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1314884001328 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1314884001329 active site 1314884001330 metal binding site [ion binding]; metal-binding site 1314884001331 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1314884001332 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 1314884001333 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1314884001334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1314884001335 active site 1314884001336 motif I; other site 1314884001337 motif II; other site 1314884001338 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1314884001339 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 1314884001340 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1314884001341 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1314884001342 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1314884001343 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1314884001344 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1314884001345 active site 1314884001346 8-oxo-dGMP binding site [chemical binding]; other site 1314884001347 nudix motif; other site 1314884001348 metal binding site [ion binding]; metal-binding site 1314884001349 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1314884001350 PLD-like domain; Region: PLDc_2; pfam13091 1314884001351 putative homodimer interface [polypeptide binding]; other site 1314884001352 putative active site [active] 1314884001353 catalytic site [active] 1314884001354 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1314884001355 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1314884001356 ATP binding site [chemical binding]; other site 1314884001357 putative Mg++ binding site [ion binding]; other site 1314884001358 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1314884001359 nucleotide binding region [chemical binding]; other site 1314884001360 ATP-binding site [chemical binding]; other site 1314884001361 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1314884001362 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1314884001363 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1314884001364 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1314884001365 putative ADP-binding pocket [chemical binding]; other site 1314884001366 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1314884001367 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; pfam13579 1314884001368 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1314884001369 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1314884001370 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1314884001371 Sulfatase; Region: Sulfatase; pfam00884 1314884001372 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 1314884001373 ribonuclease R; Region: RNase_R; TIGR02063 1314884001374 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1314884001375 RNB domain; Region: RNB; pfam00773 1314884001376 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1314884001377 RNA binding site [nucleotide binding]; other site 1314884001378 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1314884001379 SmpB-tmRNA interface; other site 1314884001380 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1314884001381 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1314884001382 active pocket/dimerization site; other site 1314884001383 active site 1314884001384 phosphorylation site [posttranslational modification] 1314884001385 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1314884001386 active site 1314884001387 phosphorylation site [posttranslational modification] 1314884001388 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1314884001389 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1314884001390 Domain of unknown function (DUF956); Region: DUF956; pfam06115 1314884001391 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1314884001392 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1314884001393 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1314884001394 dimerization interface [polypeptide binding]; other site 1314884001395 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1314884001396 putative trimer interface [polypeptide binding]; other site 1314884001397 putative CoA binding site [chemical binding]; other site 1314884001398 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1314884001399 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1314884001400 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1314884001401 putative catalytic cysteine [active] 1314884001402 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1314884001403 putative active site [active] 1314884001404 metal binding site [ion binding]; metal-binding site 1314884001405 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1314884001406 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1314884001407 glutaminase active site [active] 1314884001408 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1314884001409 dimer interface [polypeptide binding]; other site 1314884001410 active site 1314884001411 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1314884001412 dimer interface [polypeptide binding]; other site 1314884001413 active site 1314884001414 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1314884001415 propionate/acetate kinase; Provisional; Region: PRK12379 1314884001416 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1314884001417 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1314884001418 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 1314884001419 active site 1314884001420 Ap4A binding cleft/pocket [chemical binding]; other site 1314884001421 P4 phosphate binding site; other site 1314884001422 nudix motif; other site 1314884001423 putative P2/P3 phosphate binding site [ion binding]; other site 1314884001424 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1314884001425 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1314884001426 active site 1314884001427 metal-binding site [ion binding] 1314884001428 nucleotide-binding site [chemical binding]; other site 1314884001429 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 1314884001430 AAA ATPase domain; Region: AAA_16; pfam13191 1314884001431 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 1314884001432 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1314884001433 ATP binding site [chemical binding]; other site 1314884001434 putative Mg++ binding site [ion binding]; other site 1314884001435 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1314884001436 nucleotide binding region [chemical binding]; other site 1314884001437 ATP-binding site [chemical binding]; other site 1314884001438 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1314884001439 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1314884001440 dimer interface [polypeptide binding]; other site 1314884001441 FMN binding site [chemical binding]; other site 1314884001442 NADPH bind site [chemical binding]; other site 1314884001443 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1314884001444 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1314884001445 ATP binding site [chemical binding]; other site 1314884001446 putative Mg++ binding site [ion binding]; other site 1314884001447 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1314884001448 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1314884001449 AAA domain; Region: AAA_21; pfam13304 1314884001450 Walker A/P-loop; other site 1314884001451 ATP binding site [chemical binding]; other site 1314884001452 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 1314884001453 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1314884001454 Plasmid replication protein; Region: Rep_2; pfam01719 1314884001455 RNA helicase; Region: RNA_helicase; pfam00910 1314884001456 Helix-turn-helix domain; Region: HTH_17; cl17695 1314884001457 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1314884001458 active site 1314884001459 DNA binding site [nucleotide binding] 1314884001460 Int/Topo IB signature motif; other site 1314884001461 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1314884001462 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1314884001463 active site 1314884001464 metal binding site [ion binding]; metal-binding site 1314884001465 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1314884001466 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1314884001467 Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856 1314884001468 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 1314884001469 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1314884001470 catalytic core [active] 1314884001471 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1314884001472 catalytic core [active] 1314884001473 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1314884001474 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1314884001475 catalytic site [active] 1314884001476 active site 1314884001477 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1314884001478 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1314884001479 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1314884001480 DNA binding site [nucleotide binding] 1314884001481 domain linker motif; other site 1314884001482 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1314884001483 dimerization interface [polypeptide binding]; other site 1314884001484 ligand binding site [chemical binding]; other site 1314884001485 sodium binding site [ion binding]; other site 1314884001486 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1314884001487 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1314884001488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1314884001489 dimer interface [polypeptide binding]; other site 1314884001490 conserved gate region; other site 1314884001491 putative PBP binding loops; other site 1314884001492 ABC-ATPase subunit interface; other site 1314884001493 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1314884001494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1314884001495 dimer interface [polypeptide binding]; other site 1314884001496 conserved gate region; other site 1314884001497 putative PBP binding loops; other site 1314884001498 ABC-ATPase subunit interface; other site 1314884001499 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 1314884001500 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1314884001501 substrate binding [chemical binding]; other site 1314884001502 active site 1314884001503 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1314884001504 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1314884001505 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1314884001506 Walker A/P-loop; other site 1314884001507 ATP binding site [chemical binding]; other site 1314884001508 Q-loop/lid; other site 1314884001509 ABC transporter signature motif; other site 1314884001510 Walker B; other site 1314884001511 D-loop; other site 1314884001512 H-loop/switch region; other site 1314884001513 TOBE domain; Region: TOBE_2; pfam08402 1314884001514 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 1314884001515 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 1314884001516 active site 1314884001517 homodimer interface [polypeptide binding]; other site 1314884001518 catalytic site [active] 1314884001519 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1314884001520 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1314884001521 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1314884001522 Bacterial surface layer protein; Region: SLAP; pfam03217 1314884001523 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1314884001524 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1314884001525 DNA-binding site [nucleotide binding]; DNA binding site 1314884001526 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1314884001527 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1314884001528 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1314884001529 active site 1314884001530 nucleotide binding site [chemical binding]; other site 1314884001531 HIGH motif; other site 1314884001532 KMSKS motif; other site 1314884001533 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1314884001534 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1314884001535 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1314884001536 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1314884001537 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1314884001538 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1314884001539 active site 1314884001540 NAD synthetase; Reviewed; Region: nadE; PRK00768 1314884001541 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1314884001542 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1314884001543 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1314884001544 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1314884001545 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1314884001546 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1314884001547 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1314884001548 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1314884001549 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1314884001550 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1314884001551 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1314884001552 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 1314884001553 hypothetical protein; Provisional; Region: PRK04351 1314884001554 SprT homologues; Region: SprT; cl01182 1314884001555 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1314884001556 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1314884001557 Part of AAA domain; Region: AAA_19; pfam13245 1314884001558 Family description; Region: UvrD_C_2; pfam13538 1314884001559 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1314884001560 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1314884001561 nucleotide binding pocket [chemical binding]; other site 1314884001562 K-X-D-G motif; other site 1314884001563 catalytic site [active] 1314884001564 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1314884001565 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1314884001566 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1314884001567 Dimer interface [polypeptide binding]; other site 1314884001568 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1314884001569 putative dimer interface [polypeptide binding]; other site 1314884001570 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 1314884001571 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1314884001572 putative dimer interface [polypeptide binding]; other site 1314884001573 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1314884001574 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1314884001575 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1314884001576 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1314884001577 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1314884001578 GatB domain; Region: GatB_Yqey; pfam02637 1314884001579 putative lipid kinase; Reviewed; Region: PRK13337 1314884001580 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1314884001581 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1314884001582 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1314884001583 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1314884001584 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1314884001585 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1314884001586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1314884001587 S-adenosylmethionine binding site [chemical binding]; other site 1314884001588 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1314884001589 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1314884001590 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1314884001591 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1314884001592 metal-binding site [ion binding] 1314884001593 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1314884001594 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1314884001595 ligand binding site [chemical binding]; other site 1314884001596 flexible hinge region; other site 1314884001597 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1314884001598 non-specific DNA interactions [nucleotide binding]; other site 1314884001599 DNA binding site [nucleotide binding] 1314884001600 sequence specific DNA binding site [nucleotide binding]; other site 1314884001601 putative cAMP binding site [chemical binding]; other site 1314884001602 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 1314884001603 putative uracil binding site [chemical binding]; other site 1314884001604 putative active site [active] 1314884001605 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1314884001606 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1314884001607 Recombinase; Region: Recombinase; pfam07508 1314884001608 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1314884001609 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1314884001610 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1314884001611 catalytic residues [active] 1314884001612 catalytic nucleophile [active] 1314884001613 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1314884001614 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1314884001615 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1314884001616 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1314884001617 Coenzyme A binding pocket [chemical binding]; other site 1314884001618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1314884001619 putative substrate translocation pore; other site 1314884001620 CAAX protease self-immunity; Region: Abi; pfam02517 1314884001621 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1314884001622 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1314884001623 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1314884001624 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1314884001625 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1314884001626 Coenzyme A binding pocket [chemical binding]; other site 1314884001627 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1314884001628 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1314884001629 active site 1314884001630 catalytic tetrad [active] 1314884001631 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1314884001632 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1314884001633 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1314884001634 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1314884001635 Walker A/P-loop; other site 1314884001636 ATP binding site [chemical binding]; other site 1314884001637 Q-loop/lid; other site 1314884001638 ABC transporter signature motif; other site 1314884001639 uracil transporter; Provisional; Region: PRK10720 1314884001640 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1314884001641 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1314884001642 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1314884001643 active site 1314884001644 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1314884001645 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1314884001646 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1314884001647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1314884001648 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1314884001649 putative substrate translocation pore; other site 1314884001650 drug efflux system protein MdtG; Provisional; Region: PRK09874 1314884001651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1314884001652 putative substrate translocation pore; other site 1314884001653 Predicted permeases [General function prediction only]; Region: COG0679 1314884001654 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1314884001655 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1314884001656 oligomer interface [polypeptide binding]; other site 1314884001657 active site 1314884001658 metal binding site [ion binding]; metal-binding site 1314884001659 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1314884001660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1314884001661 Walker A/P-loop; other site 1314884001662 ATP binding site [chemical binding]; other site 1314884001663 Q-loop/lid; other site 1314884001664 ABC transporter signature motif; other site 1314884001665 Walker B; other site 1314884001666 D-loop; other site 1314884001667 H-loop/switch region; other site 1314884001668 ABC transporter; Region: ABC_tran_2; pfam12848 1314884001669 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1314884001670 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1314884001671 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1314884001672 substrate binding pocket [chemical binding]; other site 1314884001673 membrane-bound complex binding site; other site 1314884001674 hinge residues; other site 1314884001675 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1314884001676 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1314884001677 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1314884001678 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1314884001679 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1314884001680 Walker A/P-loop; other site 1314884001681 ATP binding site [chemical binding]; other site 1314884001682 Q-loop/lid; other site 1314884001683 ABC transporter signature motif; other site 1314884001684 Walker B; other site 1314884001685 D-loop; other site 1314884001686 H-loop/switch region; other site 1314884001687 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1314884001688 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1314884001689 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1314884001690 Walker A/P-loop; other site 1314884001691 ATP binding site [chemical binding]; other site 1314884001692 Q-loop/lid; other site 1314884001693 ABC transporter signature motif; other site 1314884001694 Walker B; other site 1314884001695 D-loop; other site 1314884001696 H-loop/switch region; other site 1314884001697 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1314884001698 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1314884001699 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1314884001700 Sugar specificity; other site 1314884001701 Pyrimidine base specificity; other site 1314884001702 ATP-binding site [chemical binding]; other site 1314884001703 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1314884001704 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1314884001705 Walker A/P-loop; other site 1314884001706 ATP binding site [chemical binding]; other site 1314884001707 Q-loop/lid; other site 1314884001708 ABC transporter signature motif; other site 1314884001709 Walker B; other site 1314884001710 D-loop; other site 1314884001711 H-loop/switch region; other site 1314884001712 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1314884001713 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1314884001714 substrate binding pocket [chemical binding]; other site 1314884001715 membrane-bound complex binding site; other site 1314884001716 hinge residues; other site 1314884001717 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1314884001718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1314884001719 dimer interface [polypeptide binding]; other site 1314884001720 conserved gate region; other site 1314884001721 putative PBP binding loops; other site 1314884001722 ABC-ATPase subunit interface; other site 1314884001723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1314884001724 dimer interface [polypeptide binding]; other site 1314884001725 conserved gate region; other site 1314884001726 putative PBP binding loops; other site 1314884001727 ABC-ATPase subunit interface; other site 1314884001728 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 1314884001729 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1314884001730 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1314884001731 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1314884001732 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1314884001733 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1314884001734 nucleotide binding site/active site [active] 1314884001735 HIT family signature motif; other site 1314884001736 catalytic residue [active] 1314884001737 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1314884001738 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1314884001739 substrate binding site [chemical binding]; other site 1314884001740 dimer interface [polypeptide binding]; other site 1314884001741 ATP binding site [chemical binding]; other site 1314884001742 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1314884001743 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1314884001744 active site 1314884001745 dimer interface [polypeptide binding]; other site 1314884001746 K+ potassium transporter; Region: K_trans; pfam02705 1314884001747 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1314884001748 active site 1314884001749 tetramer interface [polypeptide binding]; other site 1314884001750 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1314884001751 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1314884001752 DNA-binding site [nucleotide binding]; DNA binding site 1314884001753 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1314884001754 Helix-turn-helix domain; Region: HTH_19; pfam12844 1314884001755 non-specific DNA binding site [nucleotide binding]; other site 1314884001756 salt bridge; other site 1314884001757 sequence-specific DNA binding site [nucleotide binding]; other site 1314884001758 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1314884001759 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1314884001760 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1314884001761 Walker A/P-loop; other site 1314884001762 ATP binding site [chemical binding]; other site 1314884001763 Q-loop/lid; other site 1314884001764 ABC transporter signature motif; other site 1314884001765 Walker B; other site 1314884001766 D-loop; other site 1314884001767 H-loop/switch region; other site 1314884001768 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1314884001769 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1314884001770 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1314884001771 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1314884001772 MarR family; Region: MarR; pfam01047 1314884001773 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1314884001774 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1314884001775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1314884001776 Walker A/P-loop; other site 1314884001777 ATP binding site [chemical binding]; other site 1314884001778 Q-loop/lid; other site 1314884001779 ABC transporter signature motif; other site 1314884001780 Walker B; other site 1314884001781 D-loop; other site 1314884001782 H-loop/switch region; other site 1314884001783 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1314884001784 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1314884001785 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1314884001786 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1314884001787 putative phosphoketolase; Provisional; Region: PRK05261 1314884001788 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1314884001789 TPP-binding site; other site 1314884001790 XFP C-terminal domain; Region: XFP_C; pfam09363 1314884001791 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1314884001792 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1314884001793 active site 1314884001794 nucleophile elbow; other site 1314884001795 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1314884001796 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1314884001797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1314884001798 active site 1314884001799 phosphorylation site [posttranslational modification] 1314884001800 intermolecular recognition site; other site 1314884001801 dimerization interface [polypeptide binding]; other site 1314884001802 LytTr DNA-binding domain; Region: LytTR; pfam04397 1314884001803 CAAX protease self-immunity; Region: Abi; pfam02517 1314884001804 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1314884001805 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1314884001806 active site 1314884001807 motif I; other site 1314884001808 motif II; other site 1314884001809 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1314884001810 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1314884001811 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1314884001812 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1314884001813 active site turn [active] 1314884001814 phosphorylation site [posttranslational modification] 1314884001815 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 1314884001816 active site turn [active] 1314884001817 phosphorylation site [posttranslational modification] 1314884001818 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1314884001819 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1314884001820 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1314884001821 putative active site [active] 1314884001822 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1314884001823 HPr interaction site; other site 1314884001824 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1314884001825 active site 1314884001826 phosphorylation site [posttranslational modification] 1314884001827 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 1314884001828 putative FMN binding site [chemical binding]; other site 1314884001829 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1314884001830 Domain of unknown function DUF21; Region: DUF21; pfam01595 1314884001831 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1314884001832 Transporter associated domain; Region: CorC_HlyC; smart01091 1314884001833 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1314884001834 active site 1314884001835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1314884001836 Helix-turn-helix domain; Region: HTH_28; pfam13518 1314884001837 HTH-like domain; Region: HTH_21; pfam13276 1314884001838 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1314884001839 Integrase core domain; Region: rve; pfam00665 1314884001840 Integrase core domain; Region: rve_2; pfam13333 1314884001841 amino acid transporter; Region: 2A0306; TIGR00909 1314884001842 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419 1314884001843 active site 1314884001844 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1314884001845 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1314884001846 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1314884001847 ATP binding site [chemical binding]; other site 1314884001848 putative Mg++ binding site [ion binding]; other site 1314884001849 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1314884001850 nucleotide binding region [chemical binding]; other site 1314884001851 ATP-binding site [chemical binding]; other site 1314884001852 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1314884001853 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1314884001854 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1314884001855 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1314884001856 active site 1314884001857 homodimer interface [polypeptide binding]; other site 1314884001858 Predicted membrane protein [Function unknown]; Region: COG2246 1314884001859 GtrA-like protein; Region: GtrA; pfam04138 1314884001860 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1314884001861 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1314884001862 methionine aminopeptidase; Provisional; Region: PRK08671 1314884001863 active site 1314884001864 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1314884001865 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1314884001866 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1314884001867 active site 1314884001868 tetramer interface; other site 1314884001869 putative acyltransferase; Provisional; Region: PRK05790 1314884001870 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1314884001871 dimer interface [polypeptide binding]; other site 1314884001872 active site 1314884001873 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1314884001874 homodimer interface [polypeptide binding]; other site 1314884001875 catalytic residues [active] 1314884001876 NAD binding site [chemical binding]; other site 1314884001877 substrate binding pocket [chemical binding]; other site 1314884001878 flexible flap; other site 1314884001879 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1314884001880 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1314884001881 dimer interface [polypeptide binding]; other site 1314884001882 active site 1314884001883 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1314884001884 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1314884001885 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1314884001886 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1314884001887 S-adenosylmethionine binding site [chemical binding]; other site 1314884001888 recombination regulator RecX; Provisional; Region: recX; PRK14135 1314884001889 Flavoprotein; Region: Flavoprotein; cl08021 1314884001890 FOG: CBS domain [General function prediction only]; Region: COG0517 1314884001891 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1314884001892 Transporter associated domain; Region: CorC_HlyC; pfam03471 1314884001893 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1314884001894 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1314884001895 G1 box; other site 1314884001896 putative GEF interaction site [polypeptide binding]; other site 1314884001897 GTP/Mg2+ binding site [chemical binding]; other site 1314884001898 Switch I region; other site 1314884001899 G2 box; other site 1314884001900 G3 box; other site 1314884001901 Switch II region; other site 1314884001902 G4 box; other site 1314884001903 G5 box; other site 1314884001904 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1314884001905 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 1314884001906 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1314884001907 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1314884001908 Walker A motif; other site 1314884001909 ATP binding site [chemical binding]; other site 1314884001910 Walker B motif; other site 1314884001911 arginine finger; other site 1314884001912 UvrB/uvrC motif; Region: UVR; pfam02151 1314884001913 endopeptidase Clp ATP-binding regulatory subunit (clpX); Region: clpX; TIGR00382 1314884001914 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1314884001915 Walker A motif; other site 1314884001916 ATP binding site [chemical binding]; other site 1314884001917 Walker B motif; other site 1314884001918 arginine finger; other site 1314884001919 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1314884001920 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1314884001921 dimerization domain swap beta strand [polypeptide binding]; other site 1314884001922 regulatory protein interface [polypeptide binding]; other site 1314884001923 active site 1314884001924 regulatory phosphorylation site [posttranslational modification]; other site 1314884001925 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1314884001926 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1314884001927 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1314884001928 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1314884001929 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1314884001930 ArsC family; Region: ArsC; pfam03960 1314884001931 putative catalytic residues [active] 1314884001932 thiol/disulfide switch; other site 1314884001933 adaptor protein; Provisional; Region: PRK02315 1314884001934 Competence protein CoiA-like family; Region: CoiA; cl11541 1314884001935 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1314884001936 catalytic residues [active] 1314884001937 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1314884001938 putative active site [active] 1314884001939 putative metal binding residues [ion binding]; other site 1314884001940 signature motif; other site 1314884001941 putative triphosphate binding site [ion binding]; other site 1314884001942 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1314884001943 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1314884001944 synthetase active site [active] 1314884001945 NTP binding site [chemical binding]; other site 1314884001946 metal binding site [ion binding]; metal-binding site 1314884001947 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1314884001948 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1314884001949 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1314884001950 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1314884001951 active site 1314884001952 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1314884001953 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1314884001954 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1314884001955 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1314884001956 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1314884001957 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1314884001958 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1314884001959 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1314884001960 motif II; other site 1314884001961 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1314884001962 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 1314884001963 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1314884001964 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1314884001965 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1314884001966 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 1314884001967 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1314884001968 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1314884001969 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1314884001970 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1314884001971 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1314884001972 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1314884001973 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1314884001974 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1314884001975 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1314884001976 classical (c) SDRs; Region: SDR_c; cd05233 1314884001977 NAD(P) binding site [chemical binding]; other site 1314884001978 active site 1314884001979 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1314884001980 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1314884001981 non-specific DNA binding site [nucleotide binding]; other site 1314884001982 salt bridge; other site 1314884001983 sequence-specific DNA binding site [nucleotide binding]; other site 1314884001984 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1314884001985 recombinase A; Provisional; Region: recA; PRK09354 1314884001986 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1314884001987 hexamer interface [polypeptide binding]; other site 1314884001988 Walker A motif; other site 1314884001989 ATP binding site [chemical binding]; other site 1314884001990 Walker B motif; other site 1314884001991 phosphodiesterase; Provisional; Region: PRK12704 1314884001992 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1314884001993 Zn2+ binding site [ion binding]; other site 1314884001994 Mg2+ binding site [ion binding]; other site 1314884001995 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1314884001996 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1314884001997 Mg++ binding site [ion binding]; other site 1314884001998 putative catalytic motif [active] 1314884001999 substrate binding site [chemical binding]; other site 1314884002000 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1314884002001 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1314884002002 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1314884002003 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1314884002004 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1314884002005 ATP binding site [chemical binding]; other site 1314884002006 putative Mg++ binding site [ion binding]; other site 1314884002007 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1314884002008 nucleotide binding region [chemical binding]; other site 1314884002009 ATP-binding site [chemical binding]; other site 1314884002010 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1314884002011 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1314884002012 active site 1314884002013 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1314884002014 30S subunit binding site; other site 1314884002015 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 1314884002016 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1314884002017 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1314884002018 nucleotide binding region [chemical binding]; other site 1314884002019 ATP-binding site [chemical binding]; other site 1314884002020 peptide chain release factor 2; Provisional; Region: PRK05589 1314884002021 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1314884002022 RF-1 domain; Region: RF-1; pfam00472 1314884002023 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1314884002024 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1314884002025 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1314884002026 Hpr binding site; other site 1314884002027 active site 1314884002028 homohexamer subunit interaction site [polypeptide binding]; other site 1314884002029 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1314884002030 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1314884002031 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1314884002032 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1314884002033 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1314884002034 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1314884002035 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1314884002036 glycogen branching enzyme; Provisional; Region: PRK12313 1314884002037 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1314884002038 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1314884002039 active site 1314884002040 catalytic site [active] 1314884002041 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1314884002042 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1314884002043 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1314884002044 ligand binding site; other site 1314884002045 oligomer interface; other site 1314884002046 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1314884002047 dimer interface [polypeptide binding]; other site 1314884002048 N-terminal domain interface [polypeptide binding]; other site 1314884002049 sulfate 1 binding site; other site 1314884002050 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 1314884002051 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1314884002052 active site 1314884002053 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1314884002054 dimer interface [polypeptide binding]; other site 1314884002055 N-terminal domain interface [polypeptide binding]; other site 1314884002056 sulfate 1 binding site; other site 1314884002057 glycogen synthase; Provisional; Region: glgA; PRK00654 1314884002058 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1314884002059 ADP-binding pocket [chemical binding]; other site 1314884002060 homodimer interface [polypeptide binding]; other site 1314884002061 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1314884002062 homodimer interface [polypeptide binding]; other site 1314884002063 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1314884002064 active site pocket [active] 1314884002065 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1314884002066 active site 1314884002067 homodimer interface [polypeptide binding]; other site 1314884002068 catalytic site [active] 1314884002069 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1314884002070 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1314884002071 active site 1314884002072 substrate binding site [chemical binding]; other site 1314884002073 metal binding site [ion binding]; metal-binding site 1314884002074 excinuclease ABC subunit B; Provisional; Region: PRK05298 1314884002075 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 1314884002076 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1314884002077 ATP-binding site [chemical binding]; other site 1314884002078 ATP binding site [chemical binding]; other site 1314884002079 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1314884002080 nucleotide binding region [chemical binding]; other site 1314884002081 ATP-binding site [chemical binding]; other site 1314884002082 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1314884002083 UvrB/uvrC motif; Region: UVR; pfam02151 1314884002084 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1314884002085 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1314884002086 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1314884002087 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1314884002088 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1314884002089 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1314884002090 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1314884002091 putative substrate binding pocket [chemical binding]; other site 1314884002092 dimer interface [polypeptide binding]; other site 1314884002093 phosphate binding site [ion binding]; other site 1314884002094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1314884002095 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1314884002096 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1314884002097 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1314884002098 oligomer interface [polypeptide binding]; other site 1314884002099 active site residues [active] 1314884002100 SH3-like domain; Region: SH3_8; pfam13457 1314884002101 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1314884002102 inner membrane transporter YjeM; Provisional; Region: PRK15238 1314884002103 Predicted transcriptional regulator [Transcription]; Region: COG3388 1314884002104 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1314884002105 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1314884002106 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1314884002107 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1314884002108 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1314884002109 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1314884002110 Phosphoglycerate kinase; Region: PGK; pfam00162 1314884002111 substrate binding site [chemical binding]; other site 1314884002112 hinge regions; other site 1314884002113 ADP binding site [chemical binding]; other site 1314884002114 catalytic site [active] 1314884002115 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1314884002116 triosephosphate isomerase; Provisional; Region: PRK14567 1314884002117 substrate binding site [chemical binding]; other site 1314884002118 dimer interface [polypeptide binding]; other site 1314884002119 catalytic triad [active] 1314884002120 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1314884002121 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1314884002122 active site 1314884002123 motif I; other site 1314884002124 motif II; other site 1314884002125 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1314884002126 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1314884002127 ligand binding site [chemical binding]; other site 1314884002128 active site 1314884002129 UGI interface [polypeptide binding]; other site 1314884002130 catalytic site [active] 1314884002131 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1314884002132 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1314884002133 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1314884002134 active site 1314884002135 catalytic site [active] 1314884002136 substrate binding site [chemical binding]; other site 1314884002137 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1314884002138 FAD binding domain; Region: FAD_binding_4; pfam01565 1314884002139 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1314884002140 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1314884002141 ABC transporter; Region: ABC_tran; pfam00005 1314884002142 Q-loop/lid; other site 1314884002143 ABC transporter signature motif; other site 1314884002144 Walker B; other site 1314884002145 D-loop; other site 1314884002146 H-loop/switch region; other site 1314884002147 TOBE domain; Region: TOBE_2; pfam08402 1314884002148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1314884002149 dimer interface [polypeptide binding]; other site 1314884002150 conserved gate region; other site 1314884002151 putative PBP binding loops; other site 1314884002152 ABC-ATPase subunit interface; other site 1314884002153 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1314884002154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1314884002155 dimer interface [polypeptide binding]; other site 1314884002156 conserved gate region; other site 1314884002157 putative PBP binding loops; other site 1314884002158 ABC-ATPase subunit interface; other site 1314884002159 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1314884002160 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1314884002161 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1314884002162 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1314884002163 YbbR-like protein; Region: YbbR; pfam07949 1314884002164 YbbR-like protein; Region: YbbR; pfam07949 1314884002165 YbbR-like protein; Region: YbbR; pfam07949 1314884002166 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1314884002167 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1314884002168 active site 1314884002169 substrate binding site [chemical binding]; other site 1314884002170 metal binding site [ion binding]; metal-binding site 1314884002171 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1314884002172 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1314884002173 active site 1314884002174 motif I; other site 1314884002175 motif II; other site 1314884002176 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1314884002177 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1314884002178 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1314884002179 active site 1314884002180 motif I; other site 1314884002181 motif II; other site 1314884002182 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1314884002183 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1314884002184 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1314884002185 active site 1314884002186 glycerate kinase; Region: TIGR00045 1314884002187 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1314884002188 CAT RNA binding domain; Region: CAT_RBD; smart01061 1314884002189 PRD domain; Region: PRD; pfam00874 1314884002190 PRD domain; Region: PRD; pfam00874 1314884002191 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1314884002192 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1314884002193 active site turn [active] 1314884002194 phosphorylation site [posttranslational modification] 1314884002195 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1314884002196 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1314884002197 HPr interaction site; other site 1314884002198 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1314884002199 active site 1314884002200 phosphorylation site [posttranslational modification] 1314884002201 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1314884002202 beta-galactosidase; Region: BGL; TIGR03356 1314884002203 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1314884002204 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1314884002205 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1314884002206 Amino acid permease; Region: AA_permease_2; pfam13520 1314884002207 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1314884002208 Predicted integral membrane protein [Function unknown]; Region: COG5652 1314884002209 hypothetical protein; Validated; Region: PRK00110 1314884002210 Type II/IV secretion system protein; Region: T2SE; pfam00437 1314884002211 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1314884002212 Walker A motif; other site 1314884002213 ATP binding site [chemical binding]; other site 1314884002214 Walker B motif; other site 1314884002215 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1314884002216 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1314884002217 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1314884002218 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1314884002219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1314884002220 S-adenosylmethionine binding site [chemical binding]; other site 1314884002221 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1314884002222 propionate/acetate kinase; Provisional; Region: PRK12379 1314884002223 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 1314884002224 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1314884002225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1314884002226 homodimer interface [polypeptide binding]; other site 1314884002227 catalytic residue [active] 1314884002228 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1314884002229 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1314884002230 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1314884002231 SdpI/YhfL protein family; Region: SdpI; pfam13630 1314884002232 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1314884002233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1314884002234 active site 1314884002235 phosphorylation site [posttranslational modification] 1314884002236 intermolecular recognition site; other site 1314884002237 dimerization interface [polypeptide binding]; other site 1314884002238 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1314884002239 DNA binding site [nucleotide binding] 1314884002240 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1314884002241 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1314884002242 dimerization interface [polypeptide binding]; other site 1314884002243 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1314884002244 dimer interface [polypeptide binding]; other site 1314884002245 phosphorylation site [posttranslational modification] 1314884002246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1314884002247 ATP binding site [chemical binding]; other site 1314884002248 Mg2+ binding site [ion binding]; other site 1314884002249 G-X-G motif; other site 1314884002250 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1314884002251 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1314884002252 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1314884002253 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1314884002254 Sulfatase; Region: Sulfatase; pfam00884 1314884002255 VanZ like family; Region: VanZ; pfam04892 1314884002256 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1314884002257 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1314884002258 active site 1314884002259 dimer interface [polypeptide binding]; other site 1314884002260 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1314884002261 dimer interface [polypeptide binding]; other site 1314884002262 active site 1314884002263 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1314884002264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1314884002265 putative substrate translocation pore; other site 1314884002266 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1314884002267 Beta-lactamase; Region: Beta-lactamase; pfam00144 1314884002268 D5 N terminal like; Region: D5_N; smart00885 1314884002269 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1314884002270 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 1314884002271 Helix-turn-helix domain; Region: HTH_17; cl17695 1314884002272 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1314884002273 non-specific DNA binding site [nucleotide binding]; other site 1314884002274 salt bridge; other site 1314884002275 sequence-specific DNA binding site [nucleotide binding]; other site 1314884002276 complex II; Region: PLN02720 1314884002277 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1314884002278 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1314884002279 Int/Topo IB signature motif; other site 1314884002280 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1314884002281 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1314884002282 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1314884002283 thymidine kinase; Provisional; Region: PRK04296 1314884002284 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1314884002285 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1314884002286 RF-1 domain; Region: RF-1; pfam00472 1314884002287 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1314884002288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1314884002289 S-adenosylmethionine binding site [chemical binding]; other site 1314884002290 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1314884002291 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1314884002292 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1314884002293 active site 1314884002294 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1314884002295 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1314884002296 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1314884002297 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1314884002298 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1314884002299 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1314884002300 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1314884002301 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1314884002302 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1314884002303 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1314884002304 beta subunit interaction interface [polypeptide binding]; other site 1314884002305 Walker A motif; other site 1314884002306 ATP binding site [chemical binding]; other site 1314884002307 Walker B motif; other site 1314884002308 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1314884002309 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1314884002310 core domain interface [polypeptide binding]; other site 1314884002311 delta subunit interface [polypeptide binding]; other site 1314884002312 epsilon subunit interface [polypeptide binding]; other site 1314884002313 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1314884002314 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1314884002315 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1314884002316 alpha subunit interaction interface [polypeptide binding]; other site 1314884002317 Walker A motif; other site 1314884002318 ATP binding site [chemical binding]; other site 1314884002319 Walker B motif; other site 1314884002320 inhibitor binding site; inhibition site 1314884002321 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1314884002322 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1314884002323 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1314884002324 gamma subunit interface [polypeptide binding]; other site 1314884002325 epsilon subunit interface [polypeptide binding]; other site 1314884002326 LBP interface [polypeptide binding]; other site 1314884002327 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1314884002328 rod shape-determining protein MreB; Provisional; Region: PRK13930 1314884002329 MreB and similar proteins; Region: MreB_like; cd10225 1314884002330 nucleotide binding site [chemical binding]; other site 1314884002331 Mg binding site [ion binding]; other site 1314884002332 putative protofilament interaction site [polypeptide binding]; other site 1314884002333 RodZ interaction site [polypeptide binding]; other site 1314884002334 Haemolytic domain; Region: Haemolytic; cl00506 1314884002335 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 1314884002336 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1314884002337 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1314884002338 Ligand Binding Site [chemical binding]; other site 1314884002339 recombination factor protein RarA; Reviewed; Region: PRK13342 1314884002340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1314884002341 Walker A motif; other site 1314884002342 ATP binding site [chemical binding]; other site 1314884002343 Walker B motif; other site 1314884002344 arginine finger; other site 1314884002345 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1314884002346 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1314884002347 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1314884002348 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1314884002349 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1314884002350 RNA binding surface [nucleotide binding]; other site 1314884002351 septation ring formation regulator EzrA; Provisional; Region: PRK04778 1314884002352 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1314884002353 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1314884002354 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1314884002355 catalytic residue [active] 1314884002356 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1314884002357 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1314884002358 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1314884002359 Ligand Binding Site [chemical binding]; other site 1314884002360 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1314884002361 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1314884002362 RNA binding surface [nucleotide binding]; other site 1314884002363 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1314884002364 active site 1314884002365 uracil binding [chemical binding]; other site 1314884002366 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1314884002367 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1314884002368 active site 1314884002369 HIGH motif; other site 1314884002370 nucleotide binding site [chemical binding]; other site 1314884002371 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1314884002372 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1314884002373 active site 1314884002374 KMSKS motif; other site 1314884002375 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1314884002376 tRNA binding surface [nucleotide binding]; other site 1314884002377 anticodon binding site; other site 1314884002378 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1314884002379 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1314884002380 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1314884002381 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1314884002382 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1314884002383 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1314884002384 motif II; other site 1314884002385 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1314884002386 MPN+ (JAMM) motif; other site 1314884002387 Zinc-binding site [ion binding]; other site 1314884002388 rod shape-determining protein MreB; Provisional; Region: PRK13927 1314884002389 MreB and similar proteins; Region: MreB_like; cd10225 1314884002390 nucleotide binding site [chemical binding]; other site 1314884002391 Mg binding site [ion binding]; other site 1314884002392 putative protofilament interaction site [polypeptide binding]; other site 1314884002393 RodZ interaction site [polypeptide binding]; other site 1314884002394 rod shape-determining protein MreC; Provisional; Region: PRK13922 1314884002395 rod shape-determining protein MreC; Region: MreC; pfam04085 1314884002396 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1314884002397 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 1314884002398 cell division protein MraZ; Reviewed; Region: PRK00326 1314884002399 MraZ protein; Region: MraZ; pfam02381 1314884002400 MraZ protein; Region: MraZ; pfam02381 1314884002401 MraW methylase family; Region: Methyltransf_5; pfam01795 1314884002402 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1314884002403 Cell division protein FtsL; Region: FtsL; cl11433 1314884002404 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1314884002405 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1314884002406 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1314884002407 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1314884002408 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1314884002409 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1314884002410 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1314884002411 Mg++ binding site [ion binding]; other site 1314884002412 putative catalytic motif [active] 1314884002413 putative substrate binding site [chemical binding]; other site 1314884002414 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1314884002415 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1314884002416 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1314884002417 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1314884002418 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1314884002419 active site 1314884002420 homodimer interface [polypeptide binding]; other site 1314884002421 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1314884002422 Cell division protein FtsQ; Region: FtsQ; pfam03799 1314884002423 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1314884002424 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1314884002425 nucleotide binding site [chemical binding]; other site 1314884002426 Cell division protein FtsA; Region: FtsA; cl17206 1314884002427 Cell division protein FtsA; Region: FtsA; pfam14450 1314884002428 cell division protein FtsZ; Validated; Region: PRK09330 1314884002429 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1314884002430 nucleotide binding site [chemical binding]; other site 1314884002431 SulA interaction site; other site 1314884002432 Protein of unknown function (DUF552); Region: DUF552; cl00775 1314884002433 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1314884002434 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1314884002435 RNA binding surface [nucleotide binding]; other site 1314884002436 DivIVA protein; Region: DivIVA; pfam05103 1314884002437 DivIVA domain; Region: DivI1A_domain; TIGR03544 1314884002438 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1314884002439 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1314884002440 active site 1314884002441 HIGH motif; other site 1314884002442 nucleotide binding site [chemical binding]; other site 1314884002443 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1314884002444 active site 1314884002445 KMSKS motif; other site 1314884002446 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1314884002447 tRNA binding surface [nucleotide binding]; other site 1314884002448 anticodon binding site; other site 1314884002449 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1314884002450 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1314884002451 DNA-binding site [nucleotide binding]; DNA binding site 1314884002452 RNA-binding motif; other site 1314884002453 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1314884002454 dimer interface [polypeptide binding]; other site 1314884002455 ADP-ribose binding site [chemical binding]; other site 1314884002456 active site 1314884002457 nudix motif; other site 1314884002458 metal binding site [ion binding]; metal-binding site 1314884002459 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1314884002460 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1314884002461 Putative amino acid metabolism; Region: DUF1831; pfam08866 1314884002462 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1314884002463 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1314884002464 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1314884002465 catalytic core [active] 1314884002466 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1314884002467 binding surface 1314884002468 TPR motif; other site 1314884002469 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1314884002470 AAA domain; Region: AAA_30; pfam13604 1314884002471 Family description; Region: UvrD_C_2; pfam13538 1314884002472 Nuclease-related domain; Region: NERD; pfam08378 1314884002473 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1314884002474 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1314884002475 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1314884002476 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1314884002477 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1314884002478 hypothetical protein; Provisional; Region: PRK13667 1314884002479 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1314884002480 active site 1314884002481 catalytic residues [active] 1314884002482 metal binding site [ion binding]; metal-binding site 1314884002483 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1314884002484 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1314884002485 G1 box; other site 1314884002486 putative GEF interaction site [polypeptide binding]; other site 1314884002487 GTP/Mg2+ binding site [chemical binding]; other site 1314884002488 Switch I region; other site 1314884002489 G2 box; other site 1314884002490 G3 box; other site 1314884002491 Switch II region; other site 1314884002492 G4 box; other site 1314884002493 G5 box; other site 1314884002494 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1314884002495 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1314884002496 cell division protein FtsW; Region: ftsW; TIGR02614 1314884002497 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 1314884002498 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1314884002499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1314884002500 S-adenosylmethionine binding site [chemical binding]; other site 1314884002501 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1314884002502 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1314884002503 active site 1314884002504 (T/H)XGH motif; other site 1314884002505 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1314884002506 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1314884002507 SLBB domain; Region: SLBB; pfam10531 1314884002508 comEA protein; Region: comE; TIGR01259 1314884002509 Helix-hairpin-helix motif; Region: HHH; pfam00633 1314884002510 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1314884002511 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1314884002512 Competence protein; Region: Competence; pfam03772 1314884002513 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1314884002514 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1314884002515 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1314884002516 DNA polymerase III, delta subunit; Region: holA; TIGR01128 1314884002517 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1314884002518 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1314884002519 16S/18S rRNA binding site [nucleotide binding]; other site 1314884002520 S13e-L30e interaction site [polypeptide binding]; other site 1314884002521 25S rRNA binding site [nucleotide binding]; other site 1314884002522 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1314884002523 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1314884002524 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1314884002525 elongation factor Tu; Reviewed; Region: PRK00049 1314884002526 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1314884002527 G1 box; other site 1314884002528 GEF interaction site [polypeptide binding]; other site 1314884002529 GTP/Mg2+ binding site [chemical binding]; other site 1314884002530 Switch I region; other site 1314884002531 G2 box; other site 1314884002532 G3 box; other site 1314884002533 Switch II region; other site 1314884002534 G4 box; other site 1314884002535 G5 box; other site 1314884002536 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1314884002537 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1314884002538 Antibiotic Binding Site [chemical binding]; other site 1314884002539 trigger factor; Provisional; Region: tig; PRK01490 1314884002540 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1314884002541 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1314884002542 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1314884002543 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1314884002544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1314884002545 Walker A motif; other site 1314884002546 ATP binding site [chemical binding]; other site 1314884002547 Walker B motif; other site 1314884002548 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1314884002549 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1314884002550 G1 box; other site 1314884002551 GTP/Mg2+ binding site [chemical binding]; other site 1314884002552 Switch I region; other site 1314884002553 G2 box; other site 1314884002554 G3 box; other site 1314884002555 Switch II region; other site 1314884002556 G4 box; other site 1314884002557 G5 box; other site 1314884002558 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1314884002559 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1314884002560 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1314884002561 aspartate kinase; Reviewed; Region: PRK09034 1314884002562 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1314884002563 putative catalytic residues [active] 1314884002564 putative nucleotide binding site [chemical binding]; other site 1314884002565 putative aspartate binding site [chemical binding]; other site 1314884002566 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1314884002567 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1314884002568 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1314884002569 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1314884002570 active site 1314884002571 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1314884002572 substrate binding site [chemical binding]; other site 1314884002573 catalytic residues [active] 1314884002574 dimer interface [polypeptide binding]; other site 1314884002575 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1314884002576 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1314884002577 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1314884002578 active site 1314884002579 trimer interface [polypeptide binding]; other site 1314884002580 substrate binding site [chemical binding]; other site 1314884002581 CoA binding site [chemical binding]; other site 1314884002582 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1314884002583 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1314884002584 metal binding site [ion binding]; metal-binding site 1314884002585 putative dimer interface [polypeptide binding]; other site 1314884002586 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1314884002587 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1314884002588 dimer interface [polypeptide binding]; other site 1314884002589 active site 1314884002590 catalytic residue [active] 1314884002591 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1314884002592 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1314884002593 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1314884002594 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1314884002595 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1314884002596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1314884002597 homodimer interface [polypeptide binding]; other site 1314884002598 catalytic residue [active] 1314884002599 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1314884002600 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1314884002601 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1314884002602 Beta-lactamase; Region: Beta-lactamase; pfam00144 1314884002603 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 1314884002604 nucleophilic elbow; other site 1314884002605 catalytic triad; other site 1314884002606 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 1314884002607 FMN-binding domain; Region: FMN_bind; pfam04205 1314884002608 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 1314884002609 active site 1314884002610 dimerization interface [polypeptide binding]; other site 1314884002611 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1314884002612 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1314884002613 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1314884002614 non-specific DNA binding site [nucleotide binding]; other site 1314884002615 salt bridge; other site 1314884002616 sequence-specific DNA binding site [nucleotide binding]; other site 1314884002617 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1314884002618 A new structural DNA glycosylase; Region: AlkD_like; cl11434 1314884002619 A new structural DNA glycosylase; Region: AlkD_like; cl11434 1314884002620 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1314884002621 active site 1314884002622 Predicted membrane protein [Function unknown]; Region: COG2261 1314884002623 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1314884002624 beta-galactosidase; Region: BGL; TIGR03356 1314884002625 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1314884002626 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1314884002627 DNA-binding site [nucleotide binding]; DNA binding site 1314884002628 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1314884002629 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1314884002630 active site 1314884002631 P-loop; other site 1314884002632 phosphorylation site [posttranslational modification] 1314884002633 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1314884002634 active site 1314884002635 methionine cluster; other site 1314884002636 phosphorylation site [posttranslational modification] 1314884002637 metal binding site [ion binding]; metal-binding site 1314884002638 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1314884002639 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 1314884002640 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1314884002641 beta-galactosidase; Region: BGL; TIGR03356 1314884002642 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1314884002643 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1314884002644 DNA-binding site [nucleotide binding]; DNA binding site 1314884002645 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1314884002646 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1314884002647 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1314884002648 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1314884002649 beta-galactosidase; Region: BGL; TIGR03356 1314884002650 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1314884002651 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1314884002652 nucleotide binding site [chemical binding]; other site 1314884002653 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1314884002654 FMN binding site [chemical binding]; other site 1314884002655 dimer interface [polypeptide binding]; other site 1314884002656 enolase; Provisional; Region: eno; PRK00077 1314884002657 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1314884002658 dimer interface [polypeptide binding]; other site 1314884002659 metal binding site [ion binding]; metal-binding site 1314884002660 substrate binding pocket [chemical binding]; other site 1314884002661 EDD domain protein, DegV family; Region: DegV; TIGR00762 1314884002662 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1314884002663 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1314884002664 active site 1314884002665 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1314884002666 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1314884002667 active site 1314884002668 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1314884002669 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1314884002670 Int/Topo IB signature motif; other site 1314884002671 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1314884002672 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1314884002673 non-specific DNA binding site [nucleotide binding]; other site 1314884002674 salt bridge; other site 1314884002675 sequence-specific DNA binding site [nucleotide binding]; other site 1314884002676 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1314884002677 non-specific DNA binding site [nucleotide binding]; other site 1314884002678 salt bridge; other site 1314884002679 sequence-specific DNA binding site [nucleotide binding]; other site 1314884002680 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1314884002681 thymidylate synthase; Region: thym_sym; TIGR03284 1314884002682 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1314884002683 dimerization interface [polypeptide binding]; other site 1314884002684 active site 1314884002685 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1314884002686 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1314884002687 folate binding site [chemical binding]; other site 1314884002688 NADP+ binding site [chemical binding]; other site 1314884002689 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1314884002690 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1314884002691 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1314884002692 motif II; other site 1314884002693 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1314884002694 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1314884002695 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1314884002696 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1314884002697 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1314884002698 Walker A/P-loop; other site 1314884002699 ATP binding site [chemical binding]; other site 1314884002700 Q-loop/lid; other site 1314884002701 ABC transporter signature motif; other site 1314884002702 Walker B; other site 1314884002703 D-loop; other site 1314884002704 H-loop/switch region; other site 1314884002705 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1314884002706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1314884002707 dimer interface [polypeptide binding]; other site 1314884002708 conserved gate region; other site 1314884002709 ABC-ATPase subunit interface; other site 1314884002710 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1314884002711 Class II fumarases; Region: Fumarase_classII; cd01362 1314884002712 active site 1314884002713 tetramer interface [polypeptide binding]; other site 1314884002714 L-aspartate oxidase; Provisional; Region: PRK06175 1314884002715 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 1314884002716 MucBP domain; Region: MucBP; pfam06458 1314884002717 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1314884002718 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1314884002719 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1314884002720 NAD binding site [chemical binding]; other site 1314884002721 dimer interface [polypeptide binding]; other site 1314884002722 substrate binding site [chemical binding]; other site 1314884002723 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1314884002724 trimer interface [polypeptide binding]; other site 1314884002725 active site 1314884002726 G bulge; other site 1314884002727 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1314884002728 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1314884002729 transmembrane helices; other site 1314884002730 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1314884002731 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1314884002732 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1314884002733 putative active site [active] 1314884002734 (T/H)XGH motif; other site 1314884002735 citrate lyase subunit gamma; Provisional; Region: PRK13253 1314884002736 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1314884002737 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1314884002738 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1314884002739 Protein of unknown function (DUF441); Region: DUF441; pfam04284 1314884002740 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1314884002741 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1314884002742 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1314884002743 Walker A/P-loop; other site 1314884002744 ATP binding site [chemical binding]; other site 1314884002745 Q-loop/lid; other site 1314884002746 ABC transporter signature motif; other site 1314884002747 Walker B; other site 1314884002748 D-loop; other site 1314884002749 H-loop/switch region; other site 1314884002750 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 1314884002751 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1314884002752 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1314884002753 Walker A/P-loop; other site 1314884002754 ATP binding site [chemical binding]; other site 1314884002755 Q-loop/lid; other site 1314884002756 ABC transporter signature motif; other site 1314884002757 Walker B; other site 1314884002758 D-loop; other site 1314884002759 H-loop/switch region; other site 1314884002760 hypothetical protein; Provisional; Region: PRK13661 1314884002761 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 1314884002762 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1314884002763 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1314884002764 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1314884002765 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1314884002766 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1314884002767 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1314884002768 putative deacylase active site [active] 1314884002769 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 1314884002770 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1314884002771 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1314884002772 S-adenosylmethionine binding site [chemical binding]; other site 1314884002773 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1314884002774 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1314884002775 Zn2+ binding site [ion binding]; other site 1314884002776 Mg2+ binding site [ion binding]; other site 1314884002777 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1314884002778 synthetase active site [active] 1314884002779 NTP binding site [chemical binding]; other site 1314884002780 metal binding site [ion binding]; metal-binding site 1314884002781 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1314884002782 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1314884002783 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1314884002784 putative active site [active] 1314884002785 dimerization interface [polypeptide binding]; other site 1314884002786 putative tRNAtyr binding site [nucleotide binding]; other site 1314884002787 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1314884002788 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1314884002789 dimer interface [polypeptide binding]; other site 1314884002790 motif 1; other site 1314884002791 active site 1314884002792 motif 2; other site 1314884002793 motif 3; other site 1314884002794 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1314884002795 anticodon binding site; other site 1314884002796 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1314884002797 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1314884002798 dimer interface [polypeptide binding]; other site 1314884002799 anticodon binding site; other site 1314884002800 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1314884002801 homodimer interface [polypeptide binding]; other site 1314884002802 motif 1; other site 1314884002803 active site 1314884002804 motif 2; other site 1314884002805 GAD domain; Region: GAD; pfam02938 1314884002806 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1314884002807 active site 1314884002808 motif 3; other site 1314884002809 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1314884002810 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1314884002811 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1314884002812 homodimer interface [polypeptide binding]; other site 1314884002813 catalytic residue [active] 1314884002814 Flavoprotein; Region: Flavoprotein; pfam02441 1314884002815 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1314884002816 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1314884002817 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1314884002818 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1314884002819 active site 1314884002820 catalytic tetrad [active] 1314884002821 sugar phosphate phosphatase; Provisional; Region: PRK10513 1314884002822 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1314884002823 active site 1314884002824 motif I; other site 1314884002825 motif II; other site 1314884002826 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1314884002827 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 1314884002828 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1314884002829 putative ligand binding site [chemical binding]; other site 1314884002830 putative NAD binding site [chemical binding]; other site 1314884002831 catalytic site [active] 1314884002832 amino acid transporter; Region: 2A0306; TIGR00909 1314884002833 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1314884002834 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1314884002835 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1314884002836 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1314884002837 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1314884002838 GIY-YIG motif/motif A; other site 1314884002839 active site 1314884002840 catalytic site [active] 1314884002841 putative DNA binding site [nucleotide binding]; other site 1314884002842 metal binding site [ion binding]; metal-binding site 1314884002843 UvrB/uvrC motif; Region: UVR; pfam02151 1314884002844 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1314884002845 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1314884002846 DNA binding site [nucleotide binding] 1314884002847 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1314884002848 GTP1/OBG; Region: GTP1_OBG; pfam01018 1314884002849 Obg GTPase; Region: Obg; cd01898 1314884002850 G1 box; other site 1314884002851 GTP/Mg2+ binding site [chemical binding]; other site 1314884002852 Switch I region; other site 1314884002853 G2 box; other site 1314884002854 G3 box; other site 1314884002855 Switch II region; other site 1314884002856 G4 box; other site 1314884002857 G5 box; other site 1314884002858 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1314884002859 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1314884002860 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1314884002861 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1314884002862 catalytic triad [active] 1314884002863 catalytic triad [active] 1314884002864 oxyanion hole [active] 1314884002865 ribonuclease Z; Region: RNase_Z; TIGR02651 1314884002866 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1314884002867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1314884002868 NAD(P) binding site [chemical binding]; other site 1314884002869 active site 1314884002870 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1314884002871 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1314884002872 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1314884002873 active site 1314884002874 metal binding site [ion binding]; metal-binding site 1314884002875 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1314884002876 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1314884002877 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1314884002878 active site 1314884002879 PHP Thumb interface [polypeptide binding]; other site 1314884002880 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1314884002881 generic binding surface I; other site 1314884002882 generic binding surface II; other site 1314884002883 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1314884002884 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1314884002885 active site 1314884002886 ADP/pyrophosphate binding site [chemical binding]; other site 1314884002887 dimerization interface [polypeptide binding]; other site 1314884002888 allosteric effector site; other site 1314884002889 fructose-1,6-bisphosphate binding site; other site 1314884002890 pyruvate kinase; Provisional; Region: PRK06354 1314884002891 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1314884002892 domain interfaces; other site 1314884002893 active site 1314884002894 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1314884002895 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1314884002896 S1 domain; Region: S1_2; pfam13509 1314884002897 MarR family; Region: MarR_2; pfam12802 1314884002898 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1314884002899 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1314884002900 active site 1314884002901 Int/Topo IB signature motif; other site 1314884002902 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1314884002903 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1314884002904 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 1314884002905 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1314884002906 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1314884002907 RNA binding surface [nucleotide binding]; other site 1314884002908 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1314884002909 active site 1314884002910 Predicted membrane protein [Function unknown]; Region: COG3601 1314884002911 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1314884002912 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1314884002913 cytidylate kinase; Provisional; Region: cmk; PRK00023 1314884002914 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1314884002915 CMP-binding site; other site 1314884002916 The sites determining sugar specificity; other site 1314884002917 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1314884002918 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1314884002919 RNA binding site [nucleotide binding]; other site 1314884002920 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1314884002921 RNA binding site [nucleotide binding]; other site 1314884002922 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1314884002923 RNA binding site [nucleotide binding]; other site 1314884002924 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1314884002925 RNA binding site [nucleotide binding]; other site 1314884002926 GTP-binding protein Der; Reviewed; Region: PRK00093 1314884002927 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1314884002928 G1 box; other site 1314884002929 GTP/Mg2+ binding site [chemical binding]; other site 1314884002930 Switch I region; other site 1314884002931 G2 box; other site 1314884002932 Switch II region; other site 1314884002933 G3 box; other site 1314884002934 G4 box; other site 1314884002935 G5 box; other site 1314884002936 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1314884002937 G1 box; other site 1314884002938 GTP/Mg2+ binding site [chemical binding]; other site 1314884002939 Switch I region; other site 1314884002940 G2 box; other site 1314884002941 G3 box; other site 1314884002942 Switch II region; other site 1314884002943 G4 box; other site 1314884002944 G5 box; other site 1314884002945 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1314884002946 IHF dimer interface [polypeptide binding]; other site 1314884002947 IHF - DNA interface [nucleotide binding]; other site 1314884002948 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1314884002949 TPR motif; other site 1314884002950 binding surface 1314884002951 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1314884002952 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1314884002953 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1314884002954 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1314884002955 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1314884002956 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1314884002957 active site 1314884002958 NTP binding site [chemical binding]; other site 1314884002959 metal binding triad [ion binding]; metal-binding site 1314884002960 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1314884002961 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1314884002962 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1314884002963 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1314884002964 EDD domain protein, DegV family; Region: DegV; TIGR00762 1314884002965 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1314884002966 hypothetical protein; Provisional; Region: PRK13672 1314884002967 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1314884002968 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 1314884002969 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1314884002970 GTP/Mg2+ binding site [chemical binding]; other site 1314884002971 G4 box; other site 1314884002972 G5 box; other site 1314884002973 G1 box; other site 1314884002974 Switch I region; other site 1314884002975 G2 box; other site 1314884002976 G3 box; other site 1314884002977 Switch II region; other site 1314884002978 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1314884002979 RNA/DNA hybrid binding site [nucleotide binding]; other site 1314884002980 active site 1314884002981 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1314884002982 DNA protecting protein DprA; Region: dprA; TIGR00732 1314884002983 DNA topoisomerase I; Validated; Region: PRK05582 1314884002984 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1314884002985 active site 1314884002986 interdomain interaction site; other site 1314884002987 putative metal-binding site [ion binding]; other site 1314884002988 nucleotide binding site [chemical binding]; other site 1314884002989 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1314884002990 domain I; other site 1314884002991 DNA binding groove [nucleotide binding] 1314884002992 phosphate binding site [ion binding]; other site 1314884002993 domain II; other site 1314884002994 domain III; other site 1314884002995 nucleotide binding site [chemical binding]; other site 1314884002996 catalytic site [active] 1314884002997 domain IV; other site 1314884002998 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1314884002999 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1314884003000 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1314884003001 Glucose inhibited division protein A; Region: GIDA; pfam01134 1314884003002 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1314884003003 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1314884003004 active site 1314884003005 DNA binding site [nucleotide binding] 1314884003006 Int/Topo IB signature motif; other site 1314884003007 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1314884003008 active site 1314884003009 HslU subunit interaction site [polypeptide binding]; other site 1314884003010 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1314884003011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1314884003012 Walker A motif; other site 1314884003013 ATP binding site [chemical binding]; other site 1314884003014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1314884003015 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1314884003016 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1314884003017 active site 1314884003018 catalytic residues [active] 1314884003019 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1314884003020 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1314884003021 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1314884003022 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1314884003023 camphor resistance protein CrcB; Provisional; Region: PRK14220 1314884003024 dipeptidase PepV; Reviewed; Region: PRK07318 1314884003025 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1314884003026 active site 1314884003027 metal binding site [ion binding]; metal-binding site 1314884003028 Amino acid permease; Region: AA_permease_2; pfam13520 1314884003029 putative ornithine decarboxylase; Region: lacto_ODC_hypo; TIGR04318 1314884003030 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1314884003031 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1314884003032 catalytic residue [active] 1314884003033 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1314884003034 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1314884003035 Aluminium resistance protein; Region: Alum_res; pfam06838 1314884003036 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1314884003037 TrkA-N domain; Region: TrkA_N; pfam02254 1314884003038 TrkA-C domain; Region: TrkA_C; pfam02080 1314884003039 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1314884003040 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1314884003041 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1314884003042 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1314884003043 ATP binding site [chemical binding]; other site 1314884003044 putative Mg++ binding site [ion binding]; other site 1314884003045 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1314884003046 nucleotide binding region [chemical binding]; other site 1314884003047 ATP-binding site [chemical binding]; other site 1314884003048 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1314884003049 HRDC domain; Region: HRDC; pfam00570 1314884003050 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1314884003051 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1314884003052 Walker A/P-loop; other site 1314884003053 ATP binding site [chemical binding]; other site 1314884003054 Q-loop/lid; other site 1314884003055 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1314884003056 ABC transporter signature motif; other site 1314884003057 Walker B; other site 1314884003058 D-loop; other site 1314884003059 H-loop/switch region; other site 1314884003060 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1314884003061 AAA domain; Region: AAA_21; pfam13304 1314884003062 Walker A/P-loop; other site 1314884003063 ATP binding site [chemical binding]; other site 1314884003064 Q-loop/lid; other site 1314884003065 ABC transporter signature motif; other site 1314884003066 Walker B; other site 1314884003067 D-loop; other site 1314884003068 H-loop/switch region; other site 1314884003069 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1314884003070 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1314884003071 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1314884003072 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1314884003073 active site 1314884003074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1314884003075 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1314884003076 Coenzyme A binding pocket [chemical binding]; other site 1314884003077 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1314884003078 Beta-lactamase; Region: Beta-lactamase; pfam00144 1314884003079 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1314884003080 pyridoxal binding site [chemical binding]; other site 1314884003081 dimer interface [polypeptide binding]; other site 1314884003082 ATP binding site [chemical binding]; other site 1314884003083 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 1314884003084 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1314884003085 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1314884003086 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1314884003087 HPr interaction site; other site 1314884003088 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1314884003089 active site 1314884003090 phosphorylation site [posttranslational modification] 1314884003091 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1314884003092 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1314884003093 active site turn [active] 1314884003094 phosphorylation site [posttranslational modification] 1314884003095 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1314884003096 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1314884003097 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1314884003098 DNA-binding site [nucleotide binding]; DNA binding site 1314884003099 UTRA domain; Region: UTRA; pfam07702 1314884003100 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1314884003101 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1314884003102 Ca binding site [ion binding]; other site 1314884003103 active site 1314884003104 catalytic site [active] 1314884003105 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1314884003106 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1314884003107 MucBP domain; Region: MucBP; pfam06458 1314884003108 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1314884003109 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1314884003110 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1314884003111 MucBP domain; Region: MucBP; pfam06458 1314884003112 MucBP domain; Region: MucBP; pfam06458 1314884003113 MucBP domain; Region: MucBP; pfam06458 1314884003114 MucBP domain; Region: MucBP; pfam06458 1314884003115 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1314884003116 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1314884003117 MucBP domain; Region: MucBP; pfam06458 1314884003118 MucBP domain; Region: MucBP; pfam06458 1314884003119 MucBP domain; Region: MucBP; pfam06458 1314884003120 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1314884003121 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1314884003122 DNA binding residues [nucleotide binding] 1314884003123 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 1314884003124 active site 1314884003125 Mn binding site [ion binding]; other site 1314884003126 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1314884003127 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1314884003128 NAD(P) binding site [chemical binding]; other site 1314884003129 putative active site [active] 1314884003130 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1314884003131 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1314884003132 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1314884003133 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1314884003134 active site 1314884003135 catalytic tetrad [active] 1314884003136 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1314884003137 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1314884003138 active site 1314884003139 catalytic tetrad [active] 1314884003140 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1314884003141 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1314884003142 active site 1314884003143 catalytic tetrad [active] 1314884003144 Bacterial surface layer protein; Region: SLAP; pfam03217 1314884003145 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1314884003146 Coenzyme A binding pocket [chemical binding]; other site 1314884003147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1314884003148 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1314884003149 NAD(P) binding site [chemical binding]; other site 1314884003150 Transcriptional regulator; Region: Rrf2; pfam02082 1314884003151 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1314884003152 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1314884003153 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1314884003154 active site 1314884003155 catalytic tetrad [active] 1314884003156 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1314884003157 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1314884003158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1314884003159 dimer interface [polypeptide binding]; other site 1314884003160 conserved gate region; other site 1314884003161 putative PBP binding loops; other site 1314884003162 ABC-ATPase subunit interface; other site 1314884003163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1314884003164 dimer interface [polypeptide binding]; other site 1314884003165 conserved gate region; other site 1314884003166 putative PBP binding loops; other site 1314884003167 ABC-ATPase subunit interface; other site 1314884003168 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1314884003169 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1314884003170 Walker A/P-loop; other site 1314884003171 ATP binding site [chemical binding]; other site 1314884003172 Q-loop/lid; other site 1314884003173 ABC transporter signature motif; other site 1314884003174 Walker B; other site 1314884003175 D-loop; other site 1314884003176 H-loop/switch region; other site 1314884003177 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1314884003178 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1314884003179 substrate binding pocket [chemical binding]; other site 1314884003180 membrane-bound complex binding site; other site 1314884003181 hinge residues; other site 1314884003182 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1314884003183 dimer interface [polypeptide binding]; other site 1314884003184 catalytic triad [active] 1314884003185 peroxidatic and resolving cysteines [active] 1314884003186 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1314884003187 catalytic core [active] 1314884003188 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1314884003189 Amidohydrolase; Region: Amidohydro_2; pfam04909 1314884003190 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1314884003191 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1314884003192 catalytic triad [active] 1314884003193 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1314884003194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1314884003195 putative substrate translocation pore; other site 1314884003196 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1314884003197 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1314884003198 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1314884003199 dimerization interface [polypeptide binding]; other site 1314884003200 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1314884003201 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1314884003202 nudix motif; other site 1314884003203 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1314884003204 nucleotide binding site/active site [active] 1314884003205 HIT family signature motif; other site 1314884003206 catalytic residue [active] 1314884003207 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1314884003208 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1314884003209 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1314884003210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1314884003211 putative substrate translocation pore; other site 1314884003212 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 1314884003213 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1314884003214 catalytic core [active] 1314884003215 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 1314884003216 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 1314884003217 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1314884003218 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1314884003219 motif II; other site 1314884003220 Membrane transport protein; Region: Mem_trans; cl09117 1314884003221 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1314884003222 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1314884003223 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1314884003224 dimerization interface [polypeptide binding]; other site 1314884003225 malate dehydrogenase; Provisional; Region: PRK13529 1314884003226 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1314884003227 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1314884003228 NAD(P) binding site [chemical binding]; other site 1314884003229 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1314884003230 recombination factor protein RarA; Reviewed; Region: PRK13342 1314884003231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1314884003232 Walker A motif; other site 1314884003233 ATP binding site [chemical binding]; other site 1314884003234 Walker B motif; other site 1314884003235 arginine finger; other site 1314884003236 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1314884003237 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1314884003238 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1314884003239 active site 1314884003240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1314884003241 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1314884003242 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1314884003243 substrate binding site [chemical binding]; other site 1314884003244 THF binding site; other site 1314884003245 zinc-binding site [ion binding]; other site 1314884003246 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1314884003247 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 1314884003248 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1314884003249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1314884003250 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1314884003251 NAD(P) binding site [chemical binding]; other site 1314884003252 active site 1314884003253 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1314884003254 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1314884003255 dimer interface [polypeptide binding]; other site 1314884003256 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1314884003257 catalytic residue [active] 1314884003258 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1314884003259 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1314884003260 substrate-cofactor binding pocket; other site 1314884003261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1314884003262 catalytic residue [active] 1314884003263 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 1314884003264 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1314884003265 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1314884003266 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 1314884003267 Predicted transcriptional regulator [Transcription]; Region: COG2378 1314884003268 HTH domain; Region: HTH_11; pfam08279 1314884003269 WYL domain; Region: WYL; pfam13280 1314884003270 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1314884003271 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1314884003272 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1314884003273 NAD binding site [chemical binding]; other site 1314884003274 homodimer interface [polypeptide binding]; other site 1314884003275 active site 1314884003276 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1314884003277 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1314884003278 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1314884003279 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1314884003280 catalytic tetrad [active] 1314884003281 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1314884003282 Sugar transport protein; Region: Sugar_transport; pfam06800 1314884003283 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1314884003284 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1314884003285 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1314884003286 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1314884003287 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1314884003288 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1314884003289 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1314884003290 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1314884003291 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1314884003292 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1314884003293 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1314884003294 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1314884003295 FAD binding pocket [chemical binding]; other site 1314884003296 conserved FAD binding motif [chemical binding]; other site 1314884003297 phosphate binding motif [ion binding]; other site 1314884003298 beta-alpha-beta structure motif; other site 1314884003299 NAD binding pocket [chemical binding]; other site 1314884003300 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1314884003301 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1314884003302 Amino acid permease; Region: AA_permease_2; pfam13520 1314884003303 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1314884003304 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1314884003305 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1314884003306 NAD(P) binding pocket [chemical binding]; other site 1314884003307 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1314884003308 helix-hairpin-helix signature motif; other site 1314884003309 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1314884003310 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1314884003311 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1314884003312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1314884003313 Mg2+ binding site [ion binding]; other site 1314884003314 G-X-G motif; other site 1314884003315 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1314884003316 anchoring element; other site 1314884003317 dimer interface [polypeptide binding]; other site 1314884003318 ATP binding site [chemical binding]; other site 1314884003319 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1314884003320 active site 1314884003321 putative metal-binding site [ion binding]; other site 1314884003322 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1314884003323 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1314884003324 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1314884003325 CAP-like domain; other site 1314884003326 active site 1314884003327 primary dimer interface [polypeptide binding]; other site 1314884003328 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1314884003329 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1314884003330 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1314884003331 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1314884003332 dimerization interface [polypeptide binding]; other site 1314884003333 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1314884003334 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1314884003335 DHHA2 domain; Region: DHHA2; pfam02833 1314884003336 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1314884003337 active site 1314884003338 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1314884003339 Fic/DOC family; Region: Fic; cl00960 1314884003340 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1314884003341 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1314884003342 Walker A/P-loop; other site 1314884003343 ATP binding site [chemical binding]; other site 1314884003344 Q-loop/lid; other site 1314884003345 ABC transporter signature motif; other site 1314884003346 Walker B; other site 1314884003347 D-loop; other site 1314884003348 H-loop/switch region; other site 1314884003349 H+ Antiporter protein; Region: 2A0121; TIGR00900 1314884003350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1314884003351 MarR family; Region: MarR_2; cl17246 1314884003352 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1314884003353 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1314884003354 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 1314884003355 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1314884003356 active site 1314884003357 Bacterial surface layer protein; Region: SLAP; pfam03217 1314884003358 topology modulation protein; Reviewed; Region: PRK08118 1314884003359 AAA domain; Region: AAA_17; pfam13207 1314884003360 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 1314884003361 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1314884003362 active site 1314884003363 DNA binding site [nucleotide binding] 1314884003364 Int/Topo IB signature motif; other site 1314884003365 EDD domain protein, DegV family; Region: DegV; TIGR00762 1314884003366 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1314884003367 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1314884003368 MarR family; Region: MarR_2; pfam12802 1314884003369 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1314884003370 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1314884003371 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 1314884003372 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1314884003373 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1314884003374 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1314884003375 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1314884003376 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1314884003377 IMP binding site; other site 1314884003378 dimer interface [polypeptide binding]; other site 1314884003379 interdomain contacts; other site 1314884003380 partial ornithine binding site; other site 1314884003381 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 1314884003382 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1314884003383 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1314884003384 conserved cys residue [active] 1314884003385 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1314884003386 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1314884003387 RNA binding surface [nucleotide binding]; other site 1314884003388 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1314884003389 active site 1314884003390 lipoprotein signal peptidase; Provisional; Region: PRK14797 1314884003391 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1314884003392 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1314884003393 Potassium binding sites [ion binding]; other site 1314884003394 Cesium cation binding sites [ion binding]; other site 1314884003395 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1314884003396 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1314884003397 active site 1314884003398 metal binding site [ion binding]; metal-binding site 1314884003399 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1314884003400 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1314884003401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1314884003402 DivIVA protein; Region: DivIVA; pfam05103 1314884003403 DivIVA domain; Region: DivI1A_domain; TIGR03544 1314884003404 hypothetical protein; Provisional; Region: PRK13660 1314884003405 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1314884003406 Transglycosylase; Region: Transgly; pfam00912 1314884003407 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1314884003408 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1314884003409 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1314884003410 endonuclease III; Region: ENDO3c; smart00478 1314884003411 minor groove reading motif; other site 1314884003412 helix-hairpin-helix signature motif; other site 1314884003413 substrate binding pocket [chemical binding]; other site 1314884003414 active site 1314884003415 Helix-turn-helix domain; Region: HTH_36; pfam13730 1314884003416 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1314884003417 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1314884003418 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1314884003419 putative dimer interface [polypeptide binding]; other site 1314884003420 putative anticodon binding site; other site 1314884003421 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1314884003422 homodimer interface [polypeptide binding]; other site 1314884003423 motif 1; other site 1314884003424 motif 2; other site 1314884003425 active site 1314884003426 motif 3; other site 1314884003427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1314884003428 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1314884003429 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1314884003430 active site 1314884003431 catalytic site [active] 1314884003432 substrate binding site [chemical binding]; other site 1314884003433 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1314884003434 ATP binding site [chemical binding]; other site 1314884003435 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1314884003436 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1314884003437 Part of AAA domain; Region: AAA_19; pfam13245 1314884003438 Family description; Region: UvrD_C_2; pfam13538 1314884003439 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1314884003440 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1314884003441 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1314884003442 mevalonate kinase; Region: mevalon_kin; TIGR00549 1314884003443 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1314884003444 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 1314884003445 diphosphomevalonate decarboxylase; Region: PLN02407 1314884003446 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1314884003447 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1314884003448 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1314884003449 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1314884003450 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1314884003451 homotetramer interface [polypeptide binding]; other site 1314884003452 FMN binding site [chemical binding]; other site 1314884003453 homodimer contacts [polypeptide binding]; other site 1314884003454 putative active site [active] 1314884003455 putative substrate binding site [chemical binding]; other site 1314884003456 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1314884003457 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1314884003458 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1314884003459 putative active site [active] 1314884003460 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1314884003461 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1314884003462 dimer interface [polypeptide binding]; other site 1314884003463 active site 1314884003464 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1314884003465 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1314884003466 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1314884003467 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1314884003468 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1314884003469 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1314884003470 catalytic residue [active] 1314884003471 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1314884003472 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1314884003473 S-adenosylmethionine binding site [chemical binding]; other site 1314884003474 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1314884003475 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1314884003476 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1314884003477 Catalytic site [active] 1314884003478 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1314884003479 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1314884003480 Walker A/P-loop; other site 1314884003481 ATP binding site [chemical binding]; other site 1314884003482 Q-loop/lid; other site 1314884003483 ABC transporter signature motif; other site 1314884003484 Walker B; other site 1314884003485 D-loop; other site 1314884003486 H-loop/switch region; other site 1314884003487 Predicted transcriptional regulators [Transcription]; Region: COG1725 1314884003488 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1314884003489 DNA-binding site [nucleotide binding]; DNA binding site 1314884003490 peptidase T; Region: peptidase-T; TIGR01882 1314884003491 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1314884003492 metal binding site [ion binding]; metal-binding site 1314884003493 dimer interface [polypeptide binding]; other site 1314884003494 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1314884003495 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1314884003496 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1314884003497 Family of unknown function (DUF633); Region: DUF633; pfam04816 1314884003498 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1314884003499 putative active site [active] 1314884003500 nucleotide binding site [chemical binding]; other site 1314884003501 nudix motif; other site 1314884003502 putative metal binding site [ion binding]; other site 1314884003503 Peptidase family M23; Region: Peptidase_M23; pfam01551 1314884003504 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1314884003505 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1314884003506 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1314884003507 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1314884003508 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1314884003509 DNA binding residues [nucleotide binding] 1314884003510 DNA primase; Validated; Region: dnaG; PRK05667 1314884003511 CHC2 zinc finger; Region: zf-CHC2; cl17510 1314884003512 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1314884003513 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1314884003514 active site 1314884003515 metal binding site [ion binding]; metal-binding site 1314884003516 interdomain interaction site; other site 1314884003517 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1314884003518 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1314884003519 DALR anticodon binding domain; Region: DALR_1; pfam05746 1314884003520 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 1314884003521 motif 1; other site 1314884003522 dimer interface [polypeptide binding]; other site 1314884003523 active site 1314884003524 motif 2; other site 1314884003525 motif 3; other site 1314884003526 Recombination protein O N terminal; Region: RecO_N; pfam11967 1314884003527 DNA repair protein RecO; Region: reco; TIGR00613 1314884003528 Recombination protein O C terminal; Region: RecO_C; pfam02565 1314884003529 GTPase Era; Reviewed; Region: era; PRK00089 1314884003530 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1314884003531 G1 box; other site 1314884003532 GTP/Mg2+ binding site [chemical binding]; other site 1314884003533 Switch I region; other site 1314884003534 G2 box; other site 1314884003535 Switch II region; other site 1314884003536 G3 box; other site 1314884003537 G4 box; other site 1314884003538 G5 box; other site 1314884003539 metal-binding heat shock protein; Provisional; Region: PRK00016 1314884003540 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1314884003541 PhoH-like protein; Region: PhoH; pfam02562 1314884003542 Yqey-like protein; Region: YqeY; pfam09424 1314884003543 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1314884003544 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 1314884003545 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1314884003546 Peptidase family M23; Region: Peptidase_M23; pfam01551 1314884003547 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1314884003548 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1314884003549 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1314884003550 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1314884003551 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1314884003552 homoserine kinase; Provisional; Region: PRK01212 1314884003553 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1314884003554 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1314884003555 homoserine dehydrogenase; Provisional; Region: PRK06349 1314884003556 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1314884003557 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1314884003558 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1314884003559 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1314884003560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1314884003561 catalytic residue [active] 1314884003562 aspartate kinase; Reviewed; Region: PRK09034 1314884003563 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1314884003564 putative catalytic residues [active] 1314884003565 putative nucleotide binding site [chemical binding]; other site 1314884003566 putative aspartate binding site [chemical binding]; other site 1314884003567 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1314884003568 allosteric regulatory residue; other site 1314884003569 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1314884003570 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1314884003571 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1314884003572 peptide binding site [polypeptide binding]; other site 1314884003573 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 1314884003574 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 1314884003575 maltose O-acetyltransferase; Provisional; Region: PRK10092 1314884003576 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1314884003577 active site 1314884003578 substrate binding site [chemical binding]; other site 1314884003579 trimer interface [polypeptide binding]; other site 1314884003580 CoA binding site [chemical binding]; other site 1314884003581 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 1314884003582 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 1314884003583 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 1314884003584 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1314884003585 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1314884003586 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1314884003587 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1314884003588 SH3-like domain; Region: SH3_8; pfam13457 1314884003589 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1314884003590 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1314884003591 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1314884003592 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1314884003593 dimerization interface [polypeptide binding]; other site 1314884003594 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1314884003595 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1314884003596 Coenzyme A binding pocket [chemical binding]; other site 1314884003597 holo-ACP synthase CitX; Region: citrate_citX; TIGR03124 1314884003598 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1314884003599 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1314884003600 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1314884003601 dimerization interface [polypeptide binding]; other site 1314884003602 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1314884003603 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 1314884003604 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1314884003605 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1314884003606 Bacterial surface layer protein; Region: SLAP; pfam03217 1314884003607 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1314884003608 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1314884003609 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1314884003610 putative active site [active] 1314884003611 catalytic site [active] 1314884003612 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1314884003613 putative active site [active] 1314884003614 catalytic site [active] 1314884003615 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1314884003616 proposed active site lysine [active] 1314884003617 conserved cys residue [active] 1314884003618 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1314884003619 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1314884003620 dimer interface [polypeptide binding]; other site 1314884003621 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1314884003622 catalytic residue [active] 1314884003623 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1314884003624 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1314884003625 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 1314884003626 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1314884003627 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1314884003628 Coenzyme A binding pocket [chemical binding]; other site 1314884003629 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1314884003630 active site 1314884003631 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1314884003632 DHH family; Region: DHH; pfam01368 1314884003633 DHHA1 domain; Region: DHHA1; pfam02272 1314884003634 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 1314884003635 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1314884003636 active site 1314884003637 catalytic site [active] 1314884003638 GTP-binding protein LepA; Provisional; Region: PRK05433 1314884003639 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1314884003640 G1 box; other site 1314884003641 putative GEF interaction site [polypeptide binding]; other site 1314884003642 GTP/Mg2+ binding site [chemical binding]; other site 1314884003643 Switch I region; other site 1314884003644 G2 box; other site 1314884003645 G3 box; other site 1314884003646 Switch II region; other site 1314884003647 G4 box; other site 1314884003648 G5 box; other site 1314884003649 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1314884003650 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1314884003651 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1314884003652 chaperone protein DnaJ; Provisional; Region: PRK14276 1314884003653 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1314884003654 HSP70 interaction site [polypeptide binding]; other site 1314884003655 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1314884003656 substrate binding site [polypeptide binding]; other site 1314884003657 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1314884003658 Zn binding sites [ion binding]; other site 1314884003659 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1314884003660 dimer interface [polypeptide binding]; other site 1314884003661 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1314884003662 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1314884003663 nucleotide binding site [chemical binding]; other site 1314884003664 NEF interaction site [polypeptide binding]; other site 1314884003665 SBD interface [polypeptide binding]; other site 1314884003666 GrpE; Region: GrpE; pfam01025 1314884003667 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1314884003668 dimer interface [polypeptide binding]; other site 1314884003669 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1314884003670 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1314884003671 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1314884003672 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1314884003673 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1314884003674 ABC transporter; Region: ABC_tran_2; pfam12848 1314884003675 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1314884003676 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1314884003677 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1314884003678 active site 1314884003679 Riboflavin kinase; Region: Flavokinase; smart00904 1314884003680 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 1314884003681 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1314884003682 RNA binding site [nucleotide binding]; other site 1314884003683 active site 1314884003684 ribosome-binding factor A; Provisional; Region: PRK13818 1314884003685 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1314884003686 translation initiation factor IF-2; Region: IF-2; TIGR00487 1314884003687 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1314884003688 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1314884003689 G1 box; other site 1314884003690 putative GEF interaction site [polypeptide binding]; other site 1314884003691 GTP/Mg2+ binding site [chemical binding]; other site 1314884003692 Switch I region; other site 1314884003693 G2 box; other site 1314884003694 G3 box; other site 1314884003695 Switch II region; other site 1314884003696 G4 box; other site 1314884003697 G5 box; other site 1314884003698 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1314884003699 Translation-initiation factor 2; Region: IF-2; pfam11987 1314884003700 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1314884003701 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1314884003702 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1314884003703 putative RNA binding cleft [nucleotide binding]; other site 1314884003704 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1314884003705 NusA N-terminal domain; Region: NusA_N; pfam08529 1314884003706 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1314884003707 RNA binding site [nucleotide binding]; other site 1314884003708 homodimer interface [polypeptide binding]; other site 1314884003709 NusA-like KH domain; Region: KH_5; pfam13184 1314884003710 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1314884003711 G-X-X-G motif; other site 1314884003712 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1314884003713 Sm and related proteins; Region: Sm_like; cl00259 1314884003714 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1314884003715 putative oligomer interface [polypeptide binding]; other site 1314884003716 putative RNA binding site [nucleotide binding]; other site 1314884003717 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1314884003718 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1314884003719 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1314884003720 generic binding surface II; other site 1314884003721 generic binding surface I; other site 1314884003722 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1314884003723 active site 1314884003724 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1314884003725 active site 1314884003726 catalytic site [active] 1314884003727 substrate binding site [chemical binding]; other site 1314884003728 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1314884003729 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1314884003730 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1314884003731 dimer interface [polypeptide binding]; other site 1314884003732 motif 1; other site 1314884003733 active site 1314884003734 motif 2; other site 1314884003735 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1314884003736 putative deacylase active site [active] 1314884003737 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1314884003738 active site 1314884003739 motif 3; other site 1314884003740 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1314884003741 anticodon binding site; other site 1314884003742 RIP metalloprotease RseP; Region: TIGR00054 1314884003743 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1314884003744 active site 1314884003745 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1314884003746 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1314884003747 protein binding site [polypeptide binding]; other site 1314884003748 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1314884003749 putative substrate binding region [chemical binding]; other site 1314884003750 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1314884003751 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1314884003752 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1314884003753 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 1314884003754 catalytic residue [active] 1314884003755 putative FPP diphosphate binding site; other site 1314884003756 putative FPP binding hydrophobic cleft; other site 1314884003757 dimer interface [polypeptide binding]; other site 1314884003758 putative IPP diphosphate binding site; other site 1314884003759 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1314884003760 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1314884003761 hinge region; other site 1314884003762 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1314884003763 putative nucleotide binding site [chemical binding]; other site 1314884003764 uridine monophosphate binding site [chemical binding]; other site 1314884003765 homohexameric interface [polypeptide binding]; other site 1314884003766 elongation factor Ts; Provisional; Region: tsf; PRK09377 1314884003767 UBA/TS-N domain; Region: UBA; pfam00627 1314884003768 Elongation factor TS; Region: EF_TS; pfam00889 1314884003769 Elongation factor TS; Region: EF_TS; pfam00889 1314884003770 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1314884003771 rRNA interaction site [nucleotide binding]; other site 1314884003772 S8 interaction site; other site 1314884003773 putative laminin-1 binding site; other site 1314884003774 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1314884003775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1314884003776 S-adenosylmethionine binding site [chemical binding]; other site 1314884003777 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1314884003778 GIY-YIG motif/motif A; other site 1314884003779 putative active site [active] 1314884003780 putative metal binding site [ion binding]; other site 1314884003781 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1314884003782 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1314884003783 putative acyl-acceptor binding pocket; other site 1314884003784 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1314884003785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1314884003786 S-adenosylmethionine binding site [chemical binding]; other site 1314884003787 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1314884003788 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1314884003789 active site 1314884003790 Zn binding site [ion binding]; other site 1314884003791 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1314884003792 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1314884003793 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1314884003794 Walker A/P-loop; other site 1314884003795 ATP binding site [chemical binding]; other site 1314884003796 Q-loop/lid; other site 1314884003797 ABC transporter signature motif; other site 1314884003798 Walker B; other site 1314884003799 D-loop; other site 1314884003800 H-loop/switch region; other site 1314884003801 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1314884003802 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1314884003803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1314884003804 Walker A/P-loop; other site 1314884003805 ATP binding site [chemical binding]; other site 1314884003806 Q-loop/lid; other site 1314884003807 ABC transporter signature motif; other site 1314884003808 Walker B; other site 1314884003809 D-loop; other site 1314884003810 H-loop/switch region; other site 1314884003811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1314884003812 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1314884003813 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1314884003814 putative DNA binding site [nucleotide binding]; other site 1314884003815 LexA repressor; Validated; Region: PRK00215 1314884003816 putative Zn2+ binding site [ion binding]; other site 1314884003817 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1314884003818 Catalytic site [active] 1314884003819 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1314884003820 active site 1314884003821 catalytic triad [active] 1314884003822 oxyanion hole [active] 1314884003823 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1314884003824 active site 1314884003825 Fe-S cluster binding site [ion binding]; other site 1314884003826 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1314884003827 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1314884003828 Ligand binding site; other site 1314884003829 Putative Catalytic site; other site 1314884003830 DXD motif; other site 1314884003831 GtrA-like protein; Region: GtrA; pfam04138 1314884003832 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1314884003833 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1314884003834 RimM N-terminal domain; Region: RimM; pfam01782 1314884003835 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1314884003836 signal recognition particle protein; Provisional; Region: PRK10867 1314884003837 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1314884003838 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1314884003839 P loop; other site 1314884003840 GTP binding site [chemical binding]; other site 1314884003841 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1314884003842 putative DNA-binding protein; Validated; Region: PRK00118 1314884003843 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1314884003844 amino acid transporter; Region: 2A0306; TIGR00909 1314884003845 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1314884003846 Peptidase family C69; Region: Peptidase_C69; pfam03577 1314884003847 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1314884003848 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1314884003849 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1314884003850 P loop; other site 1314884003851 GTP binding site [chemical binding]; other site 1314884003852 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1314884003853 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1314884003854 Walker A/P-loop; other site 1314884003855 ATP binding site [chemical binding]; other site 1314884003856 Q-loop/lid; other site 1314884003857 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1314884003858 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1314884003859 ABC transporter signature motif; other site 1314884003860 Walker B; other site 1314884003861 D-loop; other site 1314884003862 H-loop/switch region; other site 1314884003863 ribonuclease III; Reviewed; Region: rnc; PRK00102 1314884003864 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1314884003865 dimerization interface [polypeptide binding]; other site 1314884003866 active site 1314884003867 metal binding site [ion binding]; metal-binding site 1314884003868 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1314884003869 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1314884003870 Helix-turn-helix domain; Region: HTH_28; pfam13518 1314884003871 HTH-like domain; Region: HTH_21; pfam13276 1314884003872 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1314884003873 Integrase core domain; Region: rve; pfam00665 1314884003874 Integrase core domain; Region: rve_2; pfam13333 1314884003875 Integrase core domain; Region: rve_2; pfam13333 1314884003876 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 1314884003877 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1314884003878 peptide binding site [polypeptide binding]; other site 1314884003879 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 1314884003880 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1314884003881 peptide binding site [polypeptide binding]; other site 1314884003882 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1314884003883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1314884003884 dimer interface [polypeptide binding]; other site 1314884003885 conserved gate region; other site 1314884003886 putative PBP binding loops; other site 1314884003887 ABC-ATPase subunit interface; other site 1314884003888 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1314884003889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1314884003890 dimer interface [polypeptide binding]; other site 1314884003891 conserved gate region; other site 1314884003892 putative PBP binding loops; other site 1314884003893 ABC-ATPase subunit interface; other site 1314884003894 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1314884003895 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1314884003896 Walker A/P-loop; other site 1314884003897 ATP binding site [chemical binding]; other site 1314884003898 Q-loop/lid; other site 1314884003899 ABC transporter signature motif; other site 1314884003900 Walker B; other site 1314884003901 D-loop; other site 1314884003902 H-loop/switch region; other site 1314884003903 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1314884003904 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1314884003905 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1314884003906 Walker A/P-loop; other site 1314884003907 ATP binding site [chemical binding]; other site 1314884003908 Q-loop/lid; other site 1314884003909 ABC transporter signature motif; other site 1314884003910 Walker B; other site 1314884003911 D-loop; other site 1314884003912 H-loop/switch region; other site 1314884003913 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1314884003914 acyl carrier protein; Provisional; Region: acpP; PRK00982 1314884003915 putative phosphate acyltransferase; Provisional; Region: PRK05331 1314884003916 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1314884003917 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1314884003918 generic binding surface II; other site 1314884003919 ssDNA binding site; other site 1314884003920 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1314884003921 ATP binding site [chemical binding]; other site 1314884003922 putative Mg++ binding site [ion binding]; other site 1314884003923 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1314884003924 nucleotide binding region [chemical binding]; other site 1314884003925 ATP-binding site [chemical binding]; other site 1314884003926 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1314884003927 DAK2 domain; Region: Dak2; pfam02734 1314884003928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1314884003929 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1314884003930 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1314884003931 Thiamine pyrophosphokinase; Region: TPK; cd07995 1314884003932 active site 1314884003933 dimerization interface [polypeptide binding]; other site 1314884003934 thiamine binding site [chemical binding]; other site 1314884003935 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1314884003936 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1314884003937 substrate binding site [chemical binding]; other site 1314884003938 hexamer interface [polypeptide binding]; other site 1314884003939 metal binding site [ion binding]; metal-binding site 1314884003940 GTPase RsgA; Reviewed; Region: PRK00098 1314884003941 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1314884003942 RNA binding site [nucleotide binding]; other site 1314884003943 homodimer interface [polypeptide binding]; other site 1314884003944 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1314884003945 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1314884003946 GTP/Mg2+ binding site [chemical binding]; other site 1314884003947 G4 box; other site 1314884003948 G5 box; other site 1314884003949 G1 box; other site 1314884003950 Switch I region; other site 1314884003951 G2 box; other site 1314884003952 G3 box; other site 1314884003953 Switch II region; other site 1314884003954 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1314884003955 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1314884003956 active site 1314884003957 ATP binding site [chemical binding]; other site 1314884003958 substrate binding site [chemical binding]; other site 1314884003959 activation loop (A-loop); other site 1314884003960 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1314884003961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1314884003962 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1314884003963 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1314884003964 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1314884003965 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1314884003966 active site 1314884003967 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1314884003968 putative RNA binding site [nucleotide binding]; other site 1314884003969 NusB family; Region: NusB; pfam01029 1314884003970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1314884003971 S-adenosylmethionine binding site [chemical binding]; other site 1314884003972 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1314884003973 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1314884003974 putative active site [active] 1314884003975 substrate binding site [chemical binding]; other site 1314884003976 putative cosubstrate binding site; other site 1314884003977 catalytic site [active] 1314884003978 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1314884003979 substrate binding site [chemical binding]; other site 1314884003980 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1314884003981 primosomal protein N' Region: priA; TIGR00595 1314884003982 ATP binding site [chemical binding]; other site 1314884003983 putative Mg++ binding site [ion binding]; other site 1314884003984 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1314884003985 nucleotide binding region [chemical binding]; other site 1314884003986 ATP-binding site [chemical binding]; other site 1314884003987 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1314884003988 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1314884003989 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1314884003990 catalytic site [active] 1314884003991 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1314884003992 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1314884003993 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1314884003994 Walker A/P-loop; other site 1314884003995 ATP binding site [chemical binding]; other site 1314884003996 Q-loop/lid; other site 1314884003997 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1314884003998 ABC transporter signature motif; other site 1314884003999 Walker B; other site 1314884004000 D-loop; other site 1314884004001 H-loop/switch region; other site 1314884004002 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1314884004003 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1314884004004 RNA binding surface [nucleotide binding]; other site 1314884004005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1314884004006 S-adenosylmethionine binding site [chemical binding]; other site 1314884004007 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1314884004008 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1314884004009 substrate binding pocket [chemical binding]; other site 1314884004010 chain length determination region; other site 1314884004011 substrate-Mg2+ binding site; other site 1314884004012 catalytic residues [active] 1314884004013 aspartate-rich region 1; other site 1314884004014 active site lid residues [active] 1314884004015 aspartate-rich region 2; other site 1314884004016 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1314884004017 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1314884004018 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1314884004019 generic binding surface II; other site 1314884004020 generic binding surface I; other site 1314884004021 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1314884004022 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1314884004023 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1314884004024 homodimer interface [polypeptide binding]; other site 1314884004025 NADP binding site [chemical binding]; other site 1314884004026 substrate binding site [chemical binding]; other site 1314884004027 transcription antitermination factor NusB; Region: nusB; TIGR01951 1314884004028 putative RNA binding site [nucleotide binding]; other site 1314884004029 Asp23 family; Region: Asp23; pfam03780 1314884004030 elongation factor P; Validated; Region: PRK00529 1314884004031 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1314884004032 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1314884004033 RNA binding site [nucleotide binding]; other site 1314884004034 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1314884004035 RNA binding site [nucleotide binding]; other site 1314884004036 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1314884004037 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1314884004038 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1314884004039 active site 1314884004040 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1314884004041 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1314884004042 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1314884004043 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1314884004044 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1314884004045 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1314884004046 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 1314884004047 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1314884004048 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1314884004049 homodimer interface [polypeptide binding]; other site 1314884004050 substrate-cofactor binding pocket; other site 1314884004051 catalytic residue [active] 1314884004052 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 1314884004053 active site 1 [active] 1314884004054 dimer interface [polypeptide binding]; other site 1314884004055 hexamer interface [polypeptide binding]; other site 1314884004056 active site 2 [active] 1314884004057 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1314884004058 active site 1314884004059 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1314884004060 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1314884004061 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1314884004062 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1314884004063 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1314884004064 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1314884004065 active site 1314884004066 ATP binding site [chemical binding]; other site 1314884004067 Phosphotransferase enzyme family; Region: APH; pfam01636 1314884004068 antibiotic binding site [chemical binding]; other site 1314884004069 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1314884004070 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1314884004071 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1314884004072 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1314884004073 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1314884004074 Bacterial surface layer protein; Region: SLAP; pfam03217 1314884004075 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1314884004076 active site 1314884004077 Predicted membrane protein [Function unknown]; Region: COG2364 1314884004078 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1314884004079 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1314884004080 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1314884004081 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1314884004082 substrate binding pocket [chemical binding]; other site 1314884004083 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1314884004084 ArsC family; Region: ArsC; pfam03960 1314884004085 putative ArsC-like catalytic residues; other site 1314884004086 putative TRX-like catalytic residues [active] 1314884004087 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1314884004088 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1314884004089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1314884004090 Walker A/P-loop; other site 1314884004091 ATP binding site [chemical binding]; other site 1314884004092 Q-loop/lid; other site 1314884004093 ABC transporter signature motif; other site 1314884004094 Walker B; other site 1314884004095 D-loop; other site 1314884004096 H-loop/switch region; other site 1314884004097 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1314884004098 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1314884004099 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1314884004100 Walker A/P-loop; other site 1314884004101 ATP binding site [chemical binding]; other site 1314884004102 Q-loop/lid; other site 1314884004103 ABC transporter signature motif; other site 1314884004104 Walker B; other site 1314884004105 D-loop; other site 1314884004106 H-loop/switch region; other site 1314884004107 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1314884004108 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1314884004109 active site 1314884004110 motif I; other site 1314884004111 motif II; other site 1314884004112 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1314884004113 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1314884004114 Dimer interface [polypeptide binding]; other site 1314884004115 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1314884004116 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1314884004117 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1314884004118 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1314884004119 putative alpha-glucosidase; Provisional; Region: PRK10658 1314884004120 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1314884004121 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 1314884004122 active site 1314884004123 homotrimer interface [polypeptide binding]; other site 1314884004124 catalytic site [active] 1314884004125 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 1314884004126 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1314884004127 beta-galactosidase; Region: BGL; TIGR03356 1314884004128 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1314884004129 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1314884004130 nucleotide binding site [chemical binding]; other site 1314884004131 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1314884004132 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1314884004133 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1314884004134 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1314884004135 Short C-terminal domain; Region: SHOCT; pfam09851 1314884004136 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 1314884004137 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1314884004138 non-specific DNA binding site [nucleotide binding]; other site 1314884004139 salt bridge; other site 1314884004140 sequence-specific DNA binding site [nucleotide binding]; other site 1314884004141 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 1314884004142 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 1314884004143 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1314884004144 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1314884004145 SelR domain; Region: SelR; pfam01641 1314884004146 Sugar transport protein; Region: Sugar_transport; pfam06800 1314884004147 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1314884004148 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1314884004149 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1314884004150 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1314884004151 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1314884004152 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1314884004153 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1314884004154 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1314884004155 IMP binding site; other site 1314884004156 dimer interface [polypeptide binding]; other site 1314884004157 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1314884004158 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1314884004159 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1314884004160 catalytic site [active] 1314884004161 subunit interface [polypeptide binding]; other site 1314884004162 dihydroorotase; Validated; Region: pyrC; PRK09357 1314884004163 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1314884004164 active site 1314884004165 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1314884004166 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1314884004167 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1314884004168 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1314884004169 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1314884004170 active site 1314884004171 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1314884004172 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1314884004173 heterodimer interface [polypeptide binding]; other site 1314884004174 active site 1314884004175 FMN binding site [chemical binding]; other site 1314884004176 homodimer interface [polypeptide binding]; other site 1314884004177 substrate binding site [chemical binding]; other site 1314884004178 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1314884004179 active site 1314884004180 dimer interface [polypeptide binding]; other site 1314884004181 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1314884004182 active site 1314884004183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1314884004184 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1314884004185 NAD(P) binding site [chemical binding]; other site 1314884004186 active site 1314884004187 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1314884004188 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1314884004189 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1314884004190 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1314884004191 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1314884004192 motif II; other site 1314884004193 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1314884004194 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1314884004195 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1314884004196 Cl- selectivity filter; other site 1314884004197 Cl- binding residues [ion binding]; other site 1314884004198 pore gating glutamate residue; other site 1314884004199 dimer interface [polypeptide binding]; other site 1314884004200 H+/Cl- coupling transport residue; other site 1314884004201 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 1314884004202 active site 1314884004203 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1314884004204 MucBP domain; Region: MucBP; pfam06458 1314884004205 MucBP domain; Region: MucBP; pfam06458 1314884004206 MucBP domain; Region: MucBP; pfam06458 1314884004207 MucBP domain; Region: MucBP; pfam06458 1314884004208 MucBP domain; Region: MucBP; pfam06458 1314884004209 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1314884004210 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1314884004211 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1314884004212 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1314884004213 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1314884004214 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1314884004215 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1314884004216 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 1314884004217 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1314884004218 peptide binding site [polypeptide binding]; other site 1314884004219 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1314884004220 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1314884004221 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1314884004222 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1314884004223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 1314884004224 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1314884004225 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1314884004226 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1314884004227 NAD(P) binding site [chemical binding]; other site 1314884004228 putative active site [active] 1314884004229 PemK-like protein; Region: PemK; pfam02452 1314884004230 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1314884004231 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1314884004232 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1314884004233 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1314884004234 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1314884004235 dimerization interface [polypeptide binding]; other site 1314884004236 FMN-binding domain; Region: FMN_bind; pfam04205 1314884004237 FMN-binding domain; Region: FMN_bind; pfam04205 1314884004238 FAD binding domain; Region: FAD_binding_2; pfam00890 1314884004239 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1314884004240 metal binding site [ion binding]; metal-binding site 1314884004241 active site 1314884004242 I-site; other site 1314884004243 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1314884004244 EAL domain; Region: EAL; pfam00563 1314884004245 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 1314884004246 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1314884004247 DXD motif; other site 1314884004248 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1314884004249 phosphate binding site [ion binding]; other site 1314884004250 Probable transposase; Region: OrfB_IS605; pfam01385 1314884004251 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1314884004252 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1314884004253 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1314884004254 Isochorismatase family; Region: Isochorismatase; pfam00857 1314884004255 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1314884004256 catalytic triad [active] 1314884004257 conserved cis-peptide bond; other site 1314884004258 inner membrane transporter YjeM; Provisional; Region: PRK15238 1314884004259 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1314884004260 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1314884004261 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1314884004262 catalytic tetrad [active] 1314884004263 OsmC-like protein; Region: OsmC; pfam02566 1314884004264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1314884004265 putative substrate translocation pore; other site 1314884004266 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1314884004267 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1314884004268 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1314884004269 dimer interface [polypeptide binding]; other site 1314884004270 phosphorylation site [posttranslational modification] 1314884004271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1314884004272 ATP binding site [chemical binding]; other site 1314884004273 Mg2+ binding site [ion binding]; other site 1314884004274 G-X-G motif; other site 1314884004275 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1314884004276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1314884004277 active site 1314884004278 phosphorylation site [posttranslational modification] 1314884004279 intermolecular recognition site; other site 1314884004280 dimerization interface [polypeptide binding]; other site 1314884004281 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1314884004282 DNA binding site [nucleotide binding] 1314884004283 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1314884004284 synthetase active site [active] 1314884004285 NTP binding site [chemical binding]; other site 1314884004286 metal binding site [ion binding]; metal-binding site 1314884004287 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1314884004288 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1314884004289 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 1314884004290 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 1314884004291 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1314884004292 amphipathic channel; other site 1314884004293 Asn-Pro-Ala signature motifs; other site 1314884004294 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 1314884004295 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 1314884004296 active site 1314884004297 homodimer interface [polypeptide binding]; other site 1314884004298 catalytic site [active] 1314884004299 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1314884004300 Melibiase; Region: Melibiase; pfam02065 1314884004301 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1314884004302 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1314884004303 Walker A/P-loop; other site 1314884004304 ATP binding site [chemical binding]; other site 1314884004305 Q-loop/lid; other site 1314884004306 ABC transporter signature motif; other site 1314884004307 Walker B; other site 1314884004308 D-loop; other site 1314884004309 H-loop/switch region; other site 1314884004310 TOBE domain; Region: TOBE; pfam03459 1314884004311 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1314884004312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1314884004313 dimer interface [polypeptide binding]; other site 1314884004314 conserved gate region; other site 1314884004315 putative PBP binding loops; other site 1314884004316 ABC-ATPase subunit interface; other site 1314884004317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1314884004318 dimer interface [polypeptide binding]; other site 1314884004319 conserved gate region; other site 1314884004320 putative PBP binding loops; other site 1314884004321 ABC-ATPase subunit interface; other site 1314884004322 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1314884004323 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1314884004324 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1314884004325 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1314884004326 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1314884004327 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1314884004328 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1314884004329 DNA binding residues [nucleotide binding] 1314884004330 putative dimer interface [polypeptide binding]; other site 1314884004331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1314884004332 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1314884004333 putative substrate translocation pore; other site 1314884004334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1314884004335 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 1314884004336 Bacterial surface layer protein; Region: SLAP; pfam03217 1314884004337 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1314884004338 active site 1314884004339 catalytic residues [active] 1314884004340 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1314884004341 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1314884004342 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1314884004343 galactokinase; Provisional; Region: PRK05322 1314884004344 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1314884004345 MucBP domain; Region: MucBP; pfam06458 1314884004346 MucBP domain; Region: MucBP; pfam06458 1314884004347 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1314884004348 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1314884004349 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1314884004350 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1314884004351 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1314884004352 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1314884004353 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1314884004354 HPr interaction site; other site 1314884004355 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1314884004356 active site 1314884004357 phosphorylation site [posttranslational modification] 1314884004358 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1314884004359 Probable transposase; Region: OrfB_IS605; pfam01385 1314884004360 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1314884004361 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1314884004362 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1314884004363 DNA binding site [nucleotide binding] 1314884004364 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1314884004365 putative dimerization interface [polypeptide binding]; other site 1314884004366 putative ligand binding site [chemical binding]; other site 1314884004367 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1314884004368 beta-D-glucuronidase; Provisional; Region: PRK10150 1314884004369 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1314884004370 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1314884004371 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1314884004372 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1314884004373 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1314884004374 NAD binding site [chemical binding]; other site 1314884004375 homodimer interface [polypeptide binding]; other site 1314884004376 active site 1314884004377 substrate binding site [chemical binding]; other site 1314884004378 Filamin/ABP280 repeat; Region: Filamin; pfam00630 1314884004379 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 1314884004380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1314884004381 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1314884004382 putative substrate translocation pore; other site 1314884004383 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1314884004384 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1314884004385 DNA binding site [nucleotide binding] 1314884004386 domain linker motif; other site 1314884004387 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1314884004388 dimerization interface [polypeptide binding]; other site 1314884004389 ligand binding site [chemical binding]; other site 1314884004390 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 1314884004391 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1314884004392 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1314884004393 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1314884004394 Helix-turn-helix domain; Region: HTH_28; pfam13518 1314884004395 HTH-like domain; Region: HTH_21; pfam13276 1314884004396 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1314884004397 Integrase core domain; Region: rve; pfam00665 1314884004398 Integrase core domain; Region: rve_2; pfam13333 1314884004399 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1314884004400 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1314884004401 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1314884004402 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1314884004403 active site turn [active] 1314884004404 phosphorylation site [posttranslational modification] 1314884004405 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1314884004406 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1314884004407 active site turn [active] 1314884004408 phosphorylation site [posttranslational modification] 1314884004409 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1314884004410 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1314884004411 HPr interaction site; other site 1314884004412 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1314884004413 active site 1314884004414 phosphorylation site [posttranslational modification] 1314884004415 CAT RNA binding domain; Region: CAT_RBD; smart01061 1314884004416 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1314884004417 PRD domain; Region: PRD; pfam00874 1314884004418 PRD domain; Region: PRD; pfam00874 1314884004419 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 1314884004420 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1314884004421 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1314884004422 ligand binding site [chemical binding]; other site 1314884004423 dimerization interface [polypeptide binding]; other site 1314884004424 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1314884004425 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1314884004426 TM-ABC transporter signature motif; other site 1314884004427 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1314884004428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1314884004429 Walker A/P-loop; other site 1314884004430 ATP binding site [chemical binding]; other site 1314884004431 Q-loop/lid; other site 1314884004432 ABC transporter signature motif; other site 1314884004433 Walker B; other site 1314884004434 D-loop; other site 1314884004435 H-loop/switch region; other site 1314884004436 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1314884004437 D-ribose pyranase; Provisional; Region: PRK11797 1314884004438 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1314884004439 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1314884004440 substrate binding site [chemical binding]; other site 1314884004441 dimer interface [polypeptide binding]; other site 1314884004442 ATP binding site [chemical binding]; other site 1314884004443 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 1314884004444 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1314884004445 trimer interface [polypeptide binding]; other site 1314884004446 substrate binding site [chemical binding]; other site 1314884004447 Mn binding site [ion binding]; other site 1314884004448 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1314884004449 Probable transposase; Region: OrfB_IS605; pfam01385 1314884004450 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1314884004451 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1314884004452 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1314884004453 DNA binding site [nucleotide binding] 1314884004454 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1314884004455 ligand binding site [chemical binding]; other site 1314884004456 dimerization interface [polypeptide binding]; other site 1314884004457 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1314884004458 TPP-binding site [chemical binding]; other site 1314884004459 dimer interface [polypeptide binding]; other site 1314884004460 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1314884004461 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1314884004462 PYR/PP interface [polypeptide binding]; other site 1314884004463 dimer interface [polypeptide binding]; other site 1314884004464 TPP binding site [chemical binding]; other site 1314884004465 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1314884004466 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1314884004467 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1314884004468 nucleotide binding site [chemical binding]; other site 1314884004469 Acetokinase family; Region: Acetate_kinase; cl17229 1314884004470 propionate/acetate kinase; Provisional; Region: PRK12379 1314884004471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1314884004472 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1314884004473 putative substrate translocation pore; other site 1314884004474 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 1314884004475 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1314884004476 Walker A/P-loop; other site 1314884004477 ATP binding site [chemical binding]; other site 1314884004478 Q-loop/lid; other site 1314884004479 ABC transporter signature motif; other site 1314884004480 Walker B; other site 1314884004481 D-loop; other site 1314884004482 H-loop/switch region; other site 1314884004483 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1314884004484 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1314884004485 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1314884004486 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1314884004487 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1314884004488 Aluminium resistance protein; Region: Alum_res; pfam06838 1314884004489 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1314884004490 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1314884004491 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1314884004492 active site residue [active] 1314884004493 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1314884004494 Rhomboid family; Region: Rhomboid; pfam01694 1314884004495 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1314884004496 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1314884004497 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1314884004498 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1314884004499 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1314884004500 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1314884004501 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1314884004502 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1314884004503 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1314884004504 nucleotide binding site [chemical binding]; other site 1314884004505 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 1314884004506 catalytic triad [active] 1314884004507 putative active site [active] 1314884004508 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 1314884004509 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1314884004510 Bacterial surface layer protein; Region: SLAP; pfam03217 1314884004511 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1314884004512 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1314884004513 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1314884004514 peptidase T; Region: peptidase-T; TIGR01882 1314884004515 metal binding site [ion binding]; metal-binding site 1314884004516 dimer interface [polypeptide binding]; other site 1314884004517 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1314884004518 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1314884004519 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1314884004520 NAD binding site [chemical binding]; other site 1314884004521 dimer interface [polypeptide binding]; other site 1314884004522 substrate binding site [chemical binding]; other site 1314884004523 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1314884004524 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1314884004525 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1314884004526 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1314884004527 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1314884004528 putative tRNA-binding site [nucleotide binding]; other site 1314884004529 B3/4 domain; Region: B3_4; pfam03483 1314884004530 tRNA synthetase B5 domain; Region: B5; smart00874 1314884004531 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1314884004532 dimer interface [polypeptide binding]; other site 1314884004533 motif 1; other site 1314884004534 motif 3; other site 1314884004535 motif 2; other site 1314884004536 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1314884004537 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1314884004538 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1314884004539 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1314884004540 dimer interface [polypeptide binding]; other site 1314884004541 motif 1; other site 1314884004542 active site 1314884004543 motif 2; other site 1314884004544 motif 3; other site 1314884004545 Predicted transcriptional regulators [Transcription]; Region: COG1733 1314884004546 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1314884004547 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1314884004548 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1314884004549 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1314884004550 Acylphosphatase; Region: Acylphosphatase; pfam00708 1314884004551 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1314884004552 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1314884004553 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1314884004554 dimerization interface [polypeptide binding]; other site 1314884004555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1314884004556 dimer interface [polypeptide binding]; other site 1314884004557 phosphorylation site [posttranslational modification] 1314884004558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1314884004559 ATP binding site [chemical binding]; other site 1314884004560 Mg2+ binding site [ion binding]; other site 1314884004561 G-X-G motif; other site 1314884004562 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1314884004563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1314884004564 active site 1314884004565 phosphorylation site [posttranslational modification] 1314884004566 intermolecular recognition site; other site 1314884004567 dimerization interface [polypeptide binding]; other site 1314884004568 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1314884004569 DNA binding site [nucleotide binding] 1314884004570 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1314884004571 hypothetical protein; Provisional; Region: PRK13670 1314884004572 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1314884004573 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1314884004574 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1314884004575 Zn2+ binding site [ion binding]; other site 1314884004576 Mg2+ binding site [ion binding]; other site 1314884004577 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1314884004578 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1314884004579 active site 1314884004580 (T/H)XGH motif; other site 1314884004581 GTPase YqeH; Provisional; Region: PRK13796 1314884004582 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1314884004583 GTP/Mg2+ binding site [chemical binding]; other site 1314884004584 G4 box; other site 1314884004585 G5 box; other site 1314884004586 G1 box; other site 1314884004587 Switch I region; other site 1314884004588 G2 box; other site 1314884004589 G3 box; other site 1314884004590 Switch II region; other site 1314884004591 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase 1314884004592 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1314884004593 active site 1314884004594 motif I; other site 1314884004595 motif II; other site 1314884004596 Probable transposase; Region: OrfB_IS605; pfam01385 1314884004597 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1314884004598 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1314884004599 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1314884004600 adenosine deaminase; Provisional; Region: PRK09358 1314884004601 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1314884004602 active site 1314884004603 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1314884004604 23S rRNA binding site [nucleotide binding]; other site 1314884004605 L21 binding site [polypeptide binding]; other site 1314884004606 L13 binding site [polypeptide binding]; other site 1314884004607 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1314884004608 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1314884004609 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1314884004610 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1314884004611 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1314884004612 LytTr DNA-binding domain; Region: LytTR; smart00850 1314884004613 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1314884004614 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1314884004615 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1314884004616 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1314884004617 active site 1314884004618 dimer interface [polypeptide binding]; other site 1314884004619 motif 1; other site 1314884004620 motif 2; other site 1314884004621 motif 3; other site 1314884004622 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1314884004623 anticodon binding site; other site 1314884004624 primosomal protein DnaI; Reviewed; Region: PRK08939 1314884004625 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1314884004626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1314884004627 Walker A motif; other site 1314884004628 ATP binding site [chemical binding]; other site 1314884004629 Walker B motif; other site 1314884004630 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1314884004631 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1314884004632 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1314884004633 ATP cone domain; Region: ATP-cone; pfam03477 1314884004634 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1314884004635 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1314884004636 CoA-binding site [chemical binding]; other site 1314884004637 ATP-binding [chemical binding]; other site 1314884004638 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1314884004639 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1314884004640 DNA binding site [nucleotide binding] 1314884004641 catalytic residue [active] 1314884004642 H2TH interface [polypeptide binding]; other site 1314884004643 putative catalytic residues [active] 1314884004644 turnover-facilitating residue; other site 1314884004645 intercalation triad [nucleotide binding]; other site 1314884004646 8OG recognition residue [nucleotide binding]; other site 1314884004647 putative reading head residues; other site 1314884004648 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1314884004649 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1314884004650 DNA polymerase I; Provisional; Region: PRK05755 1314884004651 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1314884004652 active site 1314884004653 metal binding site 1 [ion binding]; metal-binding site 1314884004654 putative 5' ssDNA interaction site; other site 1314884004655 metal binding site 3; metal-binding site 1314884004656 metal binding site 2 [ion binding]; metal-binding site 1314884004657 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1314884004658 putative DNA binding site [nucleotide binding]; other site 1314884004659 putative metal binding site [ion binding]; other site 1314884004660 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1314884004661 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1314884004662 active site 1314884004663 DNA binding site [nucleotide binding] 1314884004664 catalytic site [active] 1314884004665 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1314884004666 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1314884004667 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1314884004668 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1314884004669 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1314884004670 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1314884004671 purine monophosphate binding site [chemical binding]; other site 1314884004672 dimer interface [polypeptide binding]; other site 1314884004673 putative catalytic residues [active] 1314884004674 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1314884004675 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1314884004676 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 1314884004677 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1314884004678 active site 1314884004679 substrate binding site [chemical binding]; other site 1314884004680 cosubstrate binding site; other site 1314884004681 catalytic site [active] 1314884004682 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1314884004683 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1314884004684 dimerization interface [polypeptide binding]; other site 1314884004685 putative ATP binding site [chemical binding]; other site 1314884004686 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1314884004687 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1314884004688 active site 1314884004689 tetramer interface [polypeptide binding]; other site 1314884004690 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1314884004691 active site 1314884004692 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1314884004693 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1314884004694 dimerization interface [polypeptide binding]; other site 1314884004695 ATP binding site [chemical binding]; other site 1314884004696 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1314884004697 dimerization interface [polypeptide binding]; other site 1314884004698 ATP binding site [chemical binding]; other site 1314884004699 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1314884004700 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1314884004701 putative active site [active] 1314884004702 catalytic triad [active] 1314884004703 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 1314884004704 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1314884004705 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1314884004706 ATP binding site [chemical binding]; other site 1314884004707 active site 1314884004708 substrate binding site [chemical binding]; other site 1314884004709 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1314884004710 ATP-grasp domain; Region: ATP-grasp; pfam02222 1314884004711 AIR carboxylase; Region: AIRC; pfam00731 1314884004712 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1314884004713 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1314884004714 Potassium binding sites [ion binding]; other site 1314884004715 Cesium cation binding sites [ion binding]; other site 1314884004716 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1314884004717 HflC protein; Region: hflC; TIGR01932 1314884004718 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1314884004719 RelB antitoxin; Region: RelB; cl01171 1314884004720 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 1314884004721 Zn binding site [ion binding]; other site 1314884004722 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1314884004723 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1314884004724 Probable transposase; Region: OrfB_IS605; pfam01385 1314884004725 Probable transposase; Region: OrfB_IS605; pfam01385 1314884004726 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1314884004727 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1314884004728 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1314884004729 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1314884004730 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 1314884004731 active site 1314884004732 Mn binding site [ion binding]; other site 1314884004733 Predicted membrane protein [Function unknown]; Region: COG2364 1314884004734 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1314884004735 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1314884004736 beta-galactosidase; Region: BGL; TIGR03356 1314884004737 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1314884004738 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1314884004739 HPr interaction site; other site 1314884004740 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1314884004741 active site 1314884004742 phosphorylation site [posttranslational modification] 1314884004743 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1314884004744 active site turn [active] 1314884004745 phosphorylation site [posttranslational modification] 1314884004746 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1314884004747 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1314884004748 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1314884004749 putative active site [active] 1314884004750 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1314884004751 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1314884004752 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1314884004753 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1314884004754 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1314884004755 putative tRNA-binding site [nucleotide binding]; other site 1314884004756 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1314884004757 catalytic residues [active] 1314884004758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1314884004759 S-adenosylmethionine binding site [chemical binding]; other site 1314884004760 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1314884004761 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1314884004762 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1314884004763 Walker A/P-loop; other site 1314884004764 ATP binding site [chemical binding]; other site 1314884004765 Q-loop/lid; other site 1314884004766 ABC transporter signature motif; other site 1314884004767 Walker B; other site 1314884004768 D-loop; other site 1314884004769 H-loop/switch region; other site 1314884004770 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1314884004771 HIT family signature motif; other site 1314884004772 catalytic residue [active] 1314884004773 YtxH-like protein; Region: YtxH; cl02079 1314884004774 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1314884004775 SurA N-terminal domain; Region: SurA_N_3; cl07813 1314884004776 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1314884004777 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1314884004778 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1314884004779 generic binding surface I; other site 1314884004780 generic binding surface II; other site 1314884004781 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1314884004782 Zn2+ binding site [ion binding]; other site 1314884004783 Mg2+ binding site [ion binding]; other site 1314884004784 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1314884004785 AAA domain; Region: AAA_23; pfam13476 1314884004786 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1314884004787 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1314884004788 active site 1314884004789 metal binding site [ion binding]; metal-binding site 1314884004790 DNA binding site [nucleotide binding] 1314884004791 hypothetical protein; Provisional; Region: PRK13676 1314884004792 Transglycosylase; Region: Transgly; pfam00912 1314884004793 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1314884004794 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1314884004795 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1314884004796 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1314884004797 active site 1314884004798 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1314884004799 amphipathic channel; other site 1314884004800 Asn-Pro-Ala signature motifs; other site 1314884004801 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1314884004802 active site 1314884004803 substrate binding site [chemical binding]; other site 1314884004804 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1314884004805 FMN binding site [chemical binding]; other site 1314884004806 putative catalytic residues [active] 1314884004807 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1314884004808 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1314884004809 intersubunit interface [polypeptide binding]; other site 1314884004810 active site 1314884004811 zinc binding site [ion binding]; other site 1314884004812 Na+ binding site [ion binding]; other site 1314884004813 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1314884004814 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1314884004815 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1314884004816 active site 1314884004817 HIGH motif; other site 1314884004818 KMSK motif region; other site 1314884004819 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1314884004820 tRNA binding surface [nucleotide binding]; other site 1314884004821 anticodon binding site; other site 1314884004822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1314884004823 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1314884004824 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1314884004825 putative substrate binding site [chemical binding]; other site 1314884004826 putative ATP binding site [chemical binding]; other site 1314884004827 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1314884004828 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1314884004829 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1314884004830 PspC domain; Region: PspC; pfam04024 1314884004831 Beta-lactamase; Region: Beta-lactamase; pfam00144 1314884004832 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1314884004833 Tic20-like protein; Region: Tic20; pfam09685 1314884004834 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 1314884004835 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 1314884004836 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1314884004837 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1314884004838 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 1314884004839 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1314884004840 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1314884004841 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1314884004842 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1314884004843 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1314884004844 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1314884004845 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1314884004846 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1314884004847 HIGH motif; other site 1314884004848 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1314884004849 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1314884004850 active site 1314884004851 KMSKS motif; other site 1314884004852 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1314884004853 tRNA binding surface [nucleotide binding]; other site 1314884004854 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1314884004855 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1314884004856 active site 1314884004857 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1314884004858 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1314884004859 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1314884004860 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 1314884004861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1314884004862 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1314884004863 putative substrate translocation pore; other site 1314884004864 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1314884004865 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1314884004866 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1314884004867 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1314884004868 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1314884004869 seryl-tRNA synthetase; Provisional; Region: PRK05431 1314884004870 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1314884004871 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1314884004872 dimer interface [polypeptide binding]; other site 1314884004873 active site 1314884004874 motif 1; other site 1314884004875 motif 2; other site 1314884004876 motif 3; other site 1314884004877 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1314884004878 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1314884004879 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1314884004880 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1314884004881 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1314884004882 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1314884004883 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1314884004884 non-specific DNA binding site [nucleotide binding]; other site 1314884004885 salt bridge; other site 1314884004886 sequence-specific DNA binding site [nucleotide binding]; other site 1314884004887 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1314884004888 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1314884004889 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1314884004890 NAD(P) binding site [chemical binding]; other site 1314884004891 catalytic residues [active] 1314884004892 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1314884004893 Rib/alpha-like repeat; Region: Rib; pfam08428 1314884004894 Rib/alpha-like repeat; Region: Rib; pfam08428 1314884004895 Rib/alpha-like repeat; Region: Rib; pfam08428 1314884004896 Rib/alpha-like repeat; Region: Rib; pfam08428 1314884004897 Rib/alpha-like repeat; Region: Rib; pfam08428 1314884004898 Double zinc ribbon; Region: DZR; pfam12773 1314884004899 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1314884004900 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1314884004901 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1314884004902 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1314884004903 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1314884004904 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1314884004905 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1314884004906 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1314884004907 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1314884004908 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1314884004909 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1314884004910 Cl binding site [ion binding]; other site 1314884004911 oligomer interface [polypeptide binding]; other site 1314884004912 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1314884004913 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1314884004914 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1314884004915 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1314884004916 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1314884004917 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1314884004918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1314884004919 dimer interface [polypeptide binding]; other site 1314884004920 conserved gate region; other site 1314884004921 ABC-ATPase subunit interface; other site 1314884004922 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1314884004923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1314884004924 dimer interface [polypeptide binding]; other site 1314884004925 conserved gate region; other site 1314884004926 putative PBP binding loops; other site 1314884004927 ABC-ATPase subunit interface; other site 1314884004928 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1314884004929 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1314884004930 Walker A/P-loop; other site 1314884004931 ATP binding site [chemical binding]; other site 1314884004932 Q-loop/lid; other site 1314884004933 ABC transporter signature motif; other site 1314884004934 Walker B; other site 1314884004935 D-loop; other site 1314884004936 H-loop/switch region; other site 1314884004937 TOBE domain; Region: TOBE_2; pfam08402 1314884004938 Peptidase family C69; Region: Peptidase_C69; pfam03577 1314884004939 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1314884004940 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 1314884004941 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 1314884004942 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1314884004943 active site 1314884004944 catalytic site [active] 1314884004945 substrate binding site [chemical binding]; other site 1314884004946 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 1314884004947 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 1314884004948 Predicted membrane protein [Function unknown]; Region: COG2323 1314884004949 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 1314884004950 Glucan-binding protein C; Region: GbpC; pfam08363 1314884004951 MucBP domain; Region: MucBP; pfam06458 1314884004952 MucBP domain; Region: MucBP; pfam06458 1314884004953 MucBP domain; Region: MucBP; pfam06458 1314884004954 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1314884004955 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 1314884004956 PAS domain; Region: PAS_10; pfam13596 1314884004957 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1314884004958 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1314884004959 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1314884004960 Walker A/P-loop; other site 1314884004961 ATP binding site [chemical binding]; other site 1314884004962 Q-loop/lid; other site 1314884004963 ABC transporter signature motif; other site 1314884004964 Walker B; other site 1314884004965 D-loop; other site 1314884004966 H-loop/switch region; other site 1314884004967 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1314884004968 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1314884004969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1314884004970 active site 1314884004971 phosphorylation site [posttranslational modification] 1314884004972 intermolecular recognition site; other site 1314884004973 dimerization interface [polypeptide binding]; other site 1314884004974 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1314884004975 DNA binding site [nucleotide binding] 1314884004976 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1314884004977 HAMP domain; Region: HAMP; pfam00672 1314884004978 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1314884004979 dimer interface [polypeptide binding]; other site 1314884004980 phosphorylation site [posttranslational modification] 1314884004981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1314884004982 ATP binding site [chemical binding]; other site 1314884004983 Mg2+ binding site [ion binding]; other site 1314884004984 G-X-G motif; other site 1314884004985 Predicted membrane protein [Function unknown]; Region: COG3212 1314884004986 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1314884004987 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1314884004988 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1314884004989 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1314884004990 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1314884004991 MarR family; Region: MarR; pfam01047 1314884004992 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1314884004993 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1314884004994 Coenzyme A binding pocket [chemical binding]; other site 1314884004995 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1314884004996 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1314884004997 peptide binding site [polypeptide binding]; other site 1314884004998 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1314884004999 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1314884005000 elongation factor P; Validated; Region: PRK00529 1314884005001 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1314884005002 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1314884005003 RNA binding site [nucleotide binding]; other site 1314884005004 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1314884005005 RNA binding site [nucleotide binding]; other site 1314884005006 pantothenate kinase; Provisional; Region: PRK05439 1314884005007 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1314884005008 ATP-binding site [chemical binding]; other site 1314884005009 CoA-binding site [chemical binding]; other site 1314884005010 Mg2+-binding site [ion binding]; other site 1314884005011 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1314884005012 active site 1314884005013 catalytic triad [active] 1314884005014 oxyanion hole [active] 1314884005015 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1314884005016 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1314884005017 Coenzyme A binding pocket [chemical binding]; other site 1314884005018 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1314884005019 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1314884005020 substrate binding pocket [chemical binding]; other site 1314884005021 membrane-bound complex binding site; other site 1314884005022 hinge residues; other site 1314884005023 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1314884005024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1314884005025 Walker A/P-loop; other site 1314884005026 ATP binding site [chemical binding]; other site 1314884005027 Q-loop/lid; other site 1314884005028 ABC transporter signature motif; other site 1314884005029 Walker B; other site 1314884005030 D-loop; other site 1314884005031 H-loop/switch region; other site 1314884005032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1314884005033 dimer interface [polypeptide binding]; other site 1314884005034 conserved gate region; other site 1314884005035 putative PBP binding loops; other site 1314884005036 ABC-ATPase subunit interface; other site 1314884005037 Family description; Region: UvrD_C_2; pfam13538 1314884005038 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1314884005039 Part of AAA domain; Region: AAA_19; pfam13245 1314884005040 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 1314884005041 active site 1314884005042 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1314884005043 catalytic core [active] 1314884005044 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1314884005045 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1314884005046 Walker A/P-loop; other site 1314884005047 ATP binding site [chemical binding]; other site 1314884005048 Q-loop/lid; other site 1314884005049 ABC transporter signature motif; other site 1314884005050 Walker B; other site 1314884005051 D-loop; other site 1314884005052 H-loop/switch region; other site 1314884005053 Predicted membrane protein [Function unknown]; Region: COG4640 1314884005054 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 1314884005055 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1314884005056 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1314884005057 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1314884005058 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1314884005059 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1314884005060 motif II; other site 1314884005061 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1314884005062 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1314884005063 active pocket/dimerization site; other site 1314884005064 active site 1314884005065 phosphorylation site [posttranslational modification] 1314884005066 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1314884005067 active site 1314884005068 homodimer interface [polypeptide binding]; other site 1314884005069 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1314884005070 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1314884005071 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1314884005072 putative active site [active] 1314884005073 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1314884005074 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1314884005075 NAD binding site [chemical binding]; other site 1314884005076 sugar binding site [chemical binding]; other site 1314884005077 divalent metal binding site [ion binding]; other site 1314884005078 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1314884005079 dimer interface [polypeptide binding]; other site 1314884005080 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 1314884005081 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1314884005082 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1314884005083 Coenzyme A binding pocket [chemical binding]; other site 1314884005084 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 1314884005085 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1314884005086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1314884005087 homodimer interface [polypeptide binding]; other site 1314884005088 catalytic residue [active] 1314884005089 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 1314884005090 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1314884005091 TrkA-C domain; Region: TrkA_C; pfam02080 1314884005092 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1314884005093 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1314884005094 active site 1314884005095 putative catalytic site [active] 1314884005096 DNA binding site [nucleotide binding] 1314884005097 putative phosphate binding site [ion binding]; other site 1314884005098 metal binding site A [ion binding]; metal-binding site 1314884005099 AP binding site [nucleotide binding]; other site 1314884005100 metal binding site B [ion binding]; metal-binding site 1314884005101 Cupin domain; Region: Cupin_2; cl17218 1314884005102 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1314884005103 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1314884005104 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1314884005105 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1314884005106 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1314884005107 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1314884005108 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1314884005109 putative active site [active] 1314884005110 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1314884005111 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1314884005112 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1314884005113 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1314884005114 putative active site [active] 1314884005115 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1314884005116 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1314884005117 active site turn [active] 1314884005118 phosphorylation site [posttranslational modification] 1314884005119 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1314884005120 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1314884005121 HPr interaction site; other site 1314884005122 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1314884005123 active site 1314884005124 phosphorylation site [posttranslational modification] 1314884005125 beta-galactosidase; Region: BGL; TIGR03356 1314884005126 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1314884005127 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1314884005128 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1314884005129 active site turn [active] 1314884005130 phosphorylation site [posttranslational modification] 1314884005131 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1314884005132 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1314884005133 HPr interaction site; other site 1314884005134 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1314884005135 active site 1314884005136 phosphorylation site [posttranslational modification] 1314884005137 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1314884005138 CAT RNA binding domain; Region: CAT_RBD; smart01061 1314884005139 PRD domain; Region: PRD; pfam00874 1314884005140 PRD domain; Region: PRD; pfam00874 1314884005141 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1314884005142 MucBP domain; Region: MucBP; pfam06458 1314884005143 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1314884005144 carbohydrate binding site [chemical binding]; other site 1314884005145 pullulanase, type I; Region: pulA_typeI; TIGR02104 1314884005146 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1314884005147 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1314884005148 Ca binding site [ion binding]; other site 1314884005149 active site 1314884005150 catalytic site [active] 1314884005151 Bacterial surface layer protein; Region: SLAP; pfam03217 1314884005152 Predicted ATPase [General function prediction only]; Region: COG5293 1314884005153 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 1314884005154 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1314884005155 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1314884005156 active site 1314884005157 tetramer interface; other site 1314884005158 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1314884005159 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1314884005160 active site 1314884005161 homodimer interface [polypeptide binding]; other site 1314884005162 Integrase core domain; Region: rve_2; pfam13333 1314884005163 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1314884005164 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1314884005165 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1314884005166 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1314884005167 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1314884005168 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1314884005169 UDP-galactopyranose mutase; Region: GLF; pfam03275 1314884005170 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1314884005171 putative glycosyl transferase; Provisional; Region: PRK10073 1314884005172 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1314884005173 active site 1314884005174 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1314884005175 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1314884005176 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 1314884005177 Probable Catalytic site; other site 1314884005178 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 1314884005179 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1314884005180 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1314884005181 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1314884005182 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1314884005183 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1314884005184 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1314884005185 Chain length determinant protein; Region: Wzz; cl15801 1314884005186 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1314884005187 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1314884005188 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1314884005189 HflX GTPase family; Region: HflX; cd01878 1314884005190 G1 box; other site 1314884005191 GTP/Mg2+ binding site [chemical binding]; other site 1314884005192 Switch I region; other site 1314884005193 G2 box; other site 1314884005194 G3 box; other site 1314884005195 Switch II region; other site 1314884005196 G4 box; other site 1314884005197 G5 box; other site 1314884005198 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1314884005199 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1314884005200 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1314884005201 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1314884005202 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1314884005203 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1314884005204 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1314884005205 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1314884005206 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1314884005207 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1314884005208 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1314884005209 NlpC/P60 family; Region: NLPC_P60; pfam00877 1314884005210 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1314884005211 NlpC/P60 family; Region: NLPC_P60; pfam00877 1314884005212 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1314884005213 NlpC/P60 family; Region: NLPC_P60; pfam00877 1314884005214 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1314884005215 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 1314884005216 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1314884005217 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1314884005218 dimer interface [polypeptide binding]; other site 1314884005219 putative radical transfer pathway; other site 1314884005220 diiron center [ion binding]; other site 1314884005221 tyrosyl radical; other site 1314884005222 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1314884005223 putative active site [active] 1314884005224 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1314884005225 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1314884005226 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1314884005227 Walker A/P-loop; other site 1314884005228 ATP binding site [chemical binding]; other site 1314884005229 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1314884005230 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1314884005231 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1314884005232 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1314884005233 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1314884005234 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1314884005235 Walker A/P-loop; other site 1314884005236 ATP binding site [chemical binding]; other site 1314884005237 Q-loop/lid; other site 1314884005238 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1314884005239 ABC transporter signature motif; other site 1314884005240 Walker B; other site 1314884005241 D-loop; other site 1314884005242 ABC transporter; Region: ABC_tran_2; pfam12848 1314884005243 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1314884005244 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1314884005245 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1314884005246 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1314884005247 oligoendopeptidase F; Region: pepF; TIGR00181 1314884005248 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1314884005249 active site 1314884005250 Zn binding site [ion binding]; other site 1314884005251 L-lactate permease; Region: Lactate_perm; cl00701 1314884005252 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1314884005253 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1314884005254 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1314884005255 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1314884005256 dimer interface [polypeptide binding]; other site 1314884005257 putative PBP binding regions; other site 1314884005258 ABC-ATPase subunit interface; other site 1314884005259 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1314884005260 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1314884005261 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1314884005262 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1314884005263 intersubunit interface [polypeptide binding]; other site 1314884005264 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1314884005265 putative DNA binding site [nucleotide binding]; other site 1314884005266 dimerization interface [polypeptide binding]; other site 1314884005267 LytTr DNA-binding domain; Region: LytTR; smart00850 1314884005268 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1314884005269 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1314884005270 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1314884005271 active site 1314884005272 phosphorylation site [posttranslational modification] 1314884005273 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1314884005274 active site 1314884005275 P-loop; other site 1314884005276 phosphorylation site [posttranslational modification] 1314884005277 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1314884005278 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1314884005279 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1314884005280 putative substrate binding site [chemical binding]; other site 1314884005281 putative ATP binding site [chemical binding]; other site 1314884005282 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1314884005283 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1314884005284 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1314884005285 Fic family protein [Function unknown]; Region: COG3177 1314884005286 Fic/DOC family; Region: Fic; pfam02661 1314884005287 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1314884005288 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1314884005289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1314884005290 Walker A/P-loop; other site 1314884005291 ATP binding site [chemical binding]; other site 1314884005292 Q-loop/lid; other site 1314884005293 ABC transporter signature motif; other site 1314884005294 Walker B; other site 1314884005295 D-loop; other site 1314884005296 H-loop/switch region; other site 1314884005297 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1314884005298 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1314884005299 salt bridge; other site 1314884005300 non-specific DNA binding site [nucleotide binding]; other site 1314884005301 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1314884005302 sequence-specific DNA binding site [nucleotide binding]; other site 1314884005303 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1314884005304 catalytic residues [active] 1314884005305 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 1314884005306 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 1314884005307 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 1314884005308 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 1314884005309 putative active site [active] 1314884005310 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1314884005311 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1314884005312 Walker A/P-loop; other site 1314884005313 ATP binding site [chemical binding]; other site 1314884005314 Q-loop/lid; other site 1314884005315 ABC transporter signature motif; other site 1314884005316 Walker B; other site 1314884005317 D-loop; other site 1314884005318 H-loop/switch region; other site 1314884005319 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 1314884005320 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1314884005321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1314884005322 active site 1314884005323 phosphorylation site [posttranslational modification] 1314884005324 intermolecular recognition site; other site 1314884005325 dimerization interface [polypeptide binding]; other site 1314884005326 LytTr DNA-binding domain; Region: LytTR; smart00850 1314884005327 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1314884005328 CAAX protease self-immunity; Region: Abi; pfam02517 1314884005329 CAAX protease self-immunity; Region: Abi; pfam02517 1314884005330 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1314884005331 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1314884005332 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1314884005333 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 1314884005334 trimer interface [polypeptide binding]; other site 1314884005335 active site 1314884005336 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 1314884005337 catalytic site [active] 1314884005338 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1314884005339 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1314884005340 aspartate racemase; Region: asp_race; TIGR00035 1314884005341 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1314884005342 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1314884005343 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1314884005344 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1314884005345 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1314884005346 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1314884005347 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1314884005348 dimer interface [polypeptide binding]; other site 1314884005349 phosphorylation site [posttranslational modification] 1314884005350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1314884005351 ATP binding site [chemical binding]; other site 1314884005352 Mg2+ binding site [ion binding]; other site 1314884005353 G-X-G motif; other site 1314884005354 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1314884005355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1314884005356 active site 1314884005357 phosphorylation site [posttranslational modification] 1314884005358 intermolecular recognition site; other site 1314884005359 dimerization interface [polypeptide binding]; other site 1314884005360 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1314884005361 DNA binding site [nucleotide binding] 1314884005362 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1314884005363 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1314884005364 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1314884005365 Walker A/P-loop; other site 1314884005366 ATP binding site [chemical binding]; other site 1314884005367 Q-loop/lid; other site 1314884005368 ABC transporter signature motif; other site 1314884005369 Walker B; other site 1314884005370 D-loop; other site 1314884005371 H-loop/switch region; other site 1314884005372 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1314884005373 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1314884005374 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1314884005375 Walker A/P-loop; other site 1314884005376 ATP binding site [chemical binding]; other site 1314884005377 Q-loop/lid; other site 1314884005378 ABC transporter signature motif; other site 1314884005379 Walker B; other site 1314884005380 D-loop; other site 1314884005381 H-loop/switch region; other site 1314884005382 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 1314884005383 GTP-binding protein YchF; Reviewed; Region: PRK09601 1314884005384 YchF GTPase; Region: YchF; cd01900 1314884005385 G1 box; other site 1314884005386 GTP/Mg2+ binding site [chemical binding]; other site 1314884005387 Switch I region; other site 1314884005388 G2 box; other site 1314884005389 Switch II region; other site 1314884005390 G3 box; other site 1314884005391 G4 box; other site 1314884005392 G5 box; other site 1314884005393 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1314884005394 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1314884005395 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1314884005396 ParB-like nuclease domain; Region: ParB; smart00470 1314884005397 Helix-turn-helix; Region: HTH_3; pfam01381 1314884005398 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1314884005399 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1314884005400 P-loop; other site 1314884005401 Magnesium ion binding site [ion binding]; other site 1314884005402 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1314884005403 Magnesium ion binding site [ion binding]; other site 1314884005404 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1314884005405 ParB-like nuclease domain; Region: ParB; smart00470 1314884005406 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1314884005407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1314884005408 S-adenosylmethionine binding site [chemical binding]; other site 1314884005409 Colicin V production protein; Region: Colicin_V; pfam02674 1314884005410 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1314884005411 ApbE family; Region: ApbE; pfam02424 1314884005412 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1314884005413 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1314884005414 Predicted flavoprotein [General function prediction only]; Region: COG0431 1314884005415 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1314884005416 Predicted flavoprotein [General function prediction only]; Region: COG0431 1314884005417 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1314884005418 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1314884005419 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1314884005420 WHG domain; Region: WHG; pfam13305 1314884005421 Peptidase family C69; Region: Peptidase_C69; pfam03577 1314884005422 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1314884005423 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1314884005424 Walker A/P-loop; other site 1314884005425 ATP binding site [chemical binding]; other site 1314884005426 Q-loop/lid; other site 1314884005427 ABC transporter signature motif; other site 1314884005428 Walker B; other site 1314884005429 D-loop; other site 1314884005430 H-loop/switch region; other site 1314884005431 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1314884005432 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1314884005433 FtsX-like permease family; Region: FtsX; pfam02687 1314884005434 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1314884005435 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1314884005436 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1314884005437 catalytic core [active] 1314884005438 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1314884005439 Putative serine esterase (DUF676); Region: DUF676; pfam05057 1314884005440 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1314884005441 hypothetical protein; Validated; Region: PRK02101 1314884005442 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1314884005443 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1314884005444 nucleotide binding site/active site [active] 1314884005445 HIT family signature motif; other site 1314884005446 catalytic residue [active] 1314884005447 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1314884005448 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1314884005449 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1314884005450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1314884005451 putative substrate translocation pore; other site 1314884005452 POT family; Region: PTR2; cl17359 1314884005453 Peptidase family M1; Region: Peptidase_M1; pfam01433 1314884005454 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1314884005455 Zn binding site [ion binding]; other site 1314884005456 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 1314884005457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1314884005458 putative substrate translocation pore; other site 1314884005459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1314884005460 putative substrate translocation pore; other site 1314884005461 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1314884005462 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1314884005463 putative ADP-ribose binding site [chemical binding]; other site 1314884005464 putative active site [active] 1314884005465 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1314884005466 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1314884005467 Walker A/P-loop; other site 1314884005468 ATP binding site [chemical binding]; other site 1314884005469 Q-loop/lid; other site 1314884005470 ABC transporter signature motif; other site 1314884005471 Walker B; other site 1314884005472 D-loop; other site 1314884005473 H-loop/switch region; other site 1314884005474 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1314884005475 non-specific DNA binding site [nucleotide binding]; other site 1314884005476 salt bridge; other site 1314884005477 sequence-specific DNA binding site [nucleotide binding]; other site 1314884005478 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1314884005479 non-specific DNA binding site [nucleotide binding]; other site 1314884005480 salt bridge; other site 1314884005481 sequence-specific DNA binding site [nucleotide binding]; other site 1314884005482 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1314884005483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1314884005484 dimer interface [polypeptide binding]; other site 1314884005485 conserved gate region; other site 1314884005486 putative PBP binding loops; other site 1314884005487 ABC-ATPase subunit interface; other site 1314884005488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1314884005489 dimer interface [polypeptide binding]; other site 1314884005490 conserved gate region; other site 1314884005491 ABC-ATPase subunit interface; other site 1314884005492 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1314884005493 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1314884005494 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1314884005495 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1314884005496 Walker A/P-loop; other site 1314884005497 ATP binding site [chemical binding]; other site 1314884005498 Q-loop/lid; other site 1314884005499 ABC transporter signature motif; other site 1314884005500 Walker B; other site 1314884005501 D-loop; other site 1314884005502 H-loop/switch region; other site 1314884005503 TOBE domain; Region: TOBE_2; pfam08402 1314884005504 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1314884005505 Helix-turn-helix domain; Region: HTH_28; pfam13518 1314884005506 HTH-like domain; Region: HTH_21; pfam13276 1314884005507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1314884005508 Integrase core domain; Region: rve; pfam00665 1314884005509 Integrase core domain; Region: rve_2; pfam13333 1314884005510 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1314884005511 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1314884005512 motif II; other site 1314884005513 maltose phosphorylase; Provisional; Region: PRK13807 1314884005514 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1314884005515 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1314884005516 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1314884005517 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1314884005518 homodimer interface [polypeptide binding]; other site 1314884005519 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1314884005520 active site 1314884005521 homodimer interface [polypeptide binding]; other site 1314884005522 catalytic site [active] 1314884005523 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1314884005524 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1314884005525 Ca binding site [ion binding]; other site 1314884005526 active site 1314884005527 catalytic site [active] 1314884005528 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1314884005529 propionate/acetate kinase; Provisional; Region: PRK12379 1314884005530 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1314884005531 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1314884005532 DNA binding site [nucleotide binding] 1314884005533 domain linker motif; other site 1314884005534 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1314884005535 ligand binding site [chemical binding]; other site 1314884005536 dimerization interface [polypeptide binding]; other site 1314884005537 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1314884005538 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1314884005539 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1314884005540 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1314884005541 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1314884005542 Walker A/P-loop; other site 1314884005543 ATP binding site [chemical binding]; other site 1314884005544 Q-loop/lid; other site 1314884005545 ABC transporter signature motif; other site 1314884005546 Walker B; other site 1314884005547 D-loop; other site 1314884005548 H-loop/switch region; other site 1314884005549 glycerol kinase; Provisional; Region: glpK; PRK00047 1314884005550 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1314884005551 N- and C-terminal domain interface [polypeptide binding]; other site 1314884005552 active site 1314884005553 MgATP binding site [chemical binding]; other site 1314884005554 catalytic site [active] 1314884005555 metal binding site [ion binding]; metal-binding site 1314884005556 glycerol binding site [chemical binding]; other site 1314884005557 homotetramer interface [polypeptide binding]; other site 1314884005558 homodimer interface [polypeptide binding]; other site 1314884005559 FBP binding site [chemical binding]; other site 1314884005560 protein IIAGlc interface [polypeptide binding]; other site 1314884005561 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1314884005562 dimer interface [polypeptide binding]; other site 1314884005563 substrate binding site [chemical binding]; other site 1314884005564 ATP binding site [chemical binding]; other site 1314884005565 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 1314884005566 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1314884005567 Probable transposase; Region: OrfB_IS605; pfam01385 1314884005568 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1314884005569 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1314884005570 Piccolo Zn-finger; Region: zf-piccolo; pfam05715 1314884005571 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1314884005572 catalytic triad [active] 1314884005573 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1314884005574 NlpC/P60 family; Region: NLPC_P60; pfam00877 1314884005575 EamA-like transporter family; Region: EamA; pfam00892 1314884005576 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1314884005577 EamA-like transporter family; Region: EamA; pfam00892 1314884005578 EamA-like transporter family; Region: EamA; pfam00892 1314884005579 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1314884005580 EamA-like transporter family; Region: EamA; pfam00892 1314884005581 EamA-like transporter family; Region: EamA; pfam00892 1314884005582 EamA-like transporter family; Region: EamA; pfam00892 1314884005583 adenylosuccinate lyase; Provisional; Region: PRK07492 1314884005584 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1314884005585 tetramer interface [polypeptide binding]; other site 1314884005586 active site 1314884005587 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1314884005588 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1314884005589 GDP-binding site [chemical binding]; other site 1314884005590 ACT binding site; other site 1314884005591 IMP binding site; other site 1314884005592 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1314884005593 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1314884005594 active site 1314884005595 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1314884005596 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1314884005597 asparagine synthetase A; Reviewed; Region: PRK06462 1314884005598 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1314884005599 dimer interface [polypeptide binding]; other site 1314884005600 active site 1314884005601 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1314884005602 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1314884005603 catalytic residues [active] 1314884005604 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1314884005605 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1314884005606 dimerization interface [polypeptide binding]; other site 1314884005607 putative DNA binding site [nucleotide binding]; other site 1314884005608 putative Zn2+ binding site [ion binding]; other site 1314884005609 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1314884005610 active site residue [active] 1314884005611 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1314884005612 catalytic residues [active] 1314884005613 Amino acid permease; Region: AA_permease_2; pfam13520 1314884005614 Peptidase C26; Region: Peptidase_C26; pfam07722 1314884005615 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1314884005616 catalytic triad [active] 1314884005617 putative transport protein YifK; Provisional; Region: PRK10746 1314884005618 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1314884005619 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1314884005620 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1314884005621 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1314884005622 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1314884005623 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1314884005624 Catalytic site [active] 1314884005625 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1314884005626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1314884005627 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1314884005628 Walker A motif; other site 1314884005629 ATP binding site [chemical binding]; other site 1314884005630 Walker B motif; other site 1314884005631 arginine finger; other site 1314884005632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1314884005633 Walker A motif; other site 1314884005634 ATP binding site [chemical binding]; other site 1314884005635 Walker B motif; other site 1314884005636 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1314884005637 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1314884005638 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1314884005639 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1314884005640 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1314884005641 Walker A/P-loop; other site 1314884005642 ATP binding site [chemical binding]; other site 1314884005643 Q-loop/lid; other site 1314884005644 ABC transporter signature motif; other site 1314884005645 Walker B; other site 1314884005646 D-loop; other site 1314884005647 H-loop/switch region; other site 1314884005648 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1314884005649 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1314884005650 FtsX-like permease family; Region: FtsX; pfam02687 1314884005651 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1314884005652 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1314884005653 FtsX-like permease family; Region: FtsX; pfam02687 1314884005654 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1314884005655 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 1314884005656 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1314884005657 active site 1314884005658 Bacterial surface layer protein; Region: SLAP; pfam03217 1314884005659 Protein of unknown function (DUF975); Region: DUF975; cl10504 1314884005660 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1314884005661 Beta-lactamase; Region: Beta-lactamase; pfam00144 1314884005662 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1314884005663 DltD N-terminal region; Region: DltD_N; pfam04915 1314884005664 DltD central region; Region: DltD_M; pfam04918 1314884005665 DltD C-terminal region; Region: DltD_C; pfam04914 1314884005666 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1314884005667 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1314884005668 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1314884005669 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1314884005670 acyl-activating enzyme (AAE) consensus motif; other site 1314884005671 AMP binding site [chemical binding]; other site 1314884005672 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1314884005673 FOG: CBS domain [General function prediction only]; Region: COG0517 1314884005674 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1314884005675 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1314884005676 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1314884005677 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1314884005678 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1314884005679 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1314884005680 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1314884005681 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1314884005682 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1314884005683 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1314884005684 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1314884005685 Walker A/P-loop; other site 1314884005686 ATP binding site [chemical binding]; other site 1314884005687 Q-loop/lid; other site 1314884005688 ABC transporter signature motif; other site 1314884005689 Walker B; other site 1314884005690 D-loop; other site 1314884005691 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1314884005692 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1314884005693 non-specific DNA binding site [nucleotide binding]; other site 1314884005694 salt bridge; other site 1314884005695 sequence-specific DNA binding site [nucleotide binding]; other site 1314884005696 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1314884005697 CHAP domain; Region: CHAP; cl17642 1314884005698 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1314884005699 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1314884005700 non-specific DNA binding site [nucleotide binding]; other site 1314884005701 salt bridge; other site 1314884005702 sequence-specific DNA binding site [nucleotide binding]; other site 1314884005703 CAAX protease self-immunity; Region: Abi; pfam02517 1314884005704 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1314884005705 putative active site [active] 1314884005706 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1314884005707 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1314884005708 Walker A/P-loop; other site 1314884005709 ATP binding site [chemical binding]; other site 1314884005710 Q-loop/lid; other site 1314884005711 ABC transporter signature motif; other site 1314884005712 Walker B; other site 1314884005713 D-loop; other site 1314884005714 H-loop/switch region; other site 1314884005715 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1314884005716 FtsX-like permease family; Region: FtsX; pfam02687 1314884005717 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1314884005718 Predicted membrane protein [Function unknown]; Region: COG4684 1314884005719 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1314884005720 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1314884005721 ligand binding site [chemical binding]; other site 1314884005722 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1314884005723 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1314884005724 ligand binding site [chemical binding]; other site 1314884005725 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1314884005726 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1314884005727 Walker A/P-loop; other site 1314884005728 ATP binding site [chemical binding]; other site 1314884005729 Q-loop/lid; other site 1314884005730 ABC transporter signature motif; other site 1314884005731 Walker B; other site 1314884005732 D-loop; other site 1314884005733 H-loop/switch region; other site 1314884005734 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1314884005735 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1314884005736 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1314884005737 TM-ABC transporter signature motif; other site 1314884005738 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1314884005739 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1314884005740 TM-ABC transporter signature motif; other site 1314884005741 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1314884005742 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1314884005743 active site 1314884005744 catalytic tetrad [active] 1314884005745 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1314884005746 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1314884005747 active site 1314884005748 trimer interface [polypeptide binding]; other site 1314884005749 allosteric site; other site 1314884005750 active site lid [active] 1314884005751 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1314884005752 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1314884005753 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1314884005754 Substrate-binding site [chemical binding]; other site 1314884005755 Substrate specificity [chemical binding]; other site 1314884005756 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1314884005757 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1314884005758 Substrate-binding site [chemical binding]; other site 1314884005759 Substrate specificity [chemical binding]; other site 1314884005760 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1314884005761 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1314884005762 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1314884005763 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1314884005764 Helix-turn-helix domain; Region: HTH_28; pfam13518 1314884005765 HTH-like domain; Region: HTH_21; pfam13276 1314884005766 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1314884005767 Integrase core domain; Region: rve; pfam00665 1314884005768 Integrase core domain; Region: rve_2; pfam13333 1314884005769 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1314884005770 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1314884005771 DNA binding residues [nucleotide binding] 1314884005772 dimer interface [polypeptide binding]; other site 1314884005773 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1314884005774 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1314884005775 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1314884005776 TAP-like protein; Region: Abhydrolase_4; pfam08386 1314884005777 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1314884005778 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1314884005779 peptide binding site [polypeptide binding]; other site 1314884005780 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1314884005781 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1314884005782 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1314884005783 peptide binding site [polypeptide binding]; other site 1314884005784 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 1314884005785 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1314884005786 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1314884005787 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1314884005788 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1314884005789 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1314884005790 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1314884005791 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1314884005792 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1314884005793 putative active site [active] 1314884005794 Uncharacterized conserved protein [Function unknown]; Region: COG2013 1314884005795 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1314884005796 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1314884005797 ligand binding site [chemical binding]; other site 1314884005798 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1314884005799 putative switch regulator; other site 1314884005800 non-specific DNA interactions [nucleotide binding]; other site 1314884005801 DNA binding site [nucleotide binding] 1314884005802 sequence specific DNA binding site [nucleotide binding]; other site 1314884005803 putative cAMP binding site [chemical binding]; other site 1314884005804 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1314884005805 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1314884005806 Cl- selectivity filter; other site 1314884005807 Cl- binding residues [ion binding]; other site 1314884005808 pore gating glutamate residue; other site 1314884005809 dimer interface [polypeptide binding]; other site 1314884005810 H+/Cl- coupling transport residue; other site 1314884005811 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1314884005812 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1314884005813 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1314884005814 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1314884005815 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 1314884005816 PYR/PP interface [polypeptide binding]; other site 1314884005817 dimer interface [polypeptide binding]; other site 1314884005818 tetramer interface [polypeptide binding]; other site 1314884005819 TPP binding site [chemical binding]; other site 1314884005820 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1314884005821 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1314884005822 TPP-binding site [chemical binding]; other site 1314884005823 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1314884005824 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1314884005825 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1314884005826 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1314884005827 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1314884005828 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1314884005829 G1 box; other site 1314884005830 GTP/Mg2+ binding site [chemical binding]; other site 1314884005831 Switch I region; other site 1314884005832 G2 box; other site 1314884005833 Switch II region; other site 1314884005834 G3 box; other site 1314884005835 G4 box; other site 1314884005836 G5 box; other site 1314884005837 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1314884005838 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1314884005839 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1314884005840 Ribonuclease P; Region: Ribonuclease_P; cl00457 1314884005841 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399