-- dump date 20140619_122348 -- class Genbank::misc_feature -- table misc_feature_note -- id note 272621000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 272621000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 272621000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272621000004 Walker A motif; other site 272621000005 ATP binding site [chemical binding]; other site 272621000006 Walker B motif; other site 272621000007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 272621000008 arginine finger; other site 272621000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 272621000010 DnaA box-binding interface [nucleotide binding]; other site 272621000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 272621000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 272621000013 putative DNA binding surface [nucleotide binding]; other site 272621000014 dimer interface [polypeptide binding]; other site 272621000015 beta-clamp/clamp loader binding surface; other site 272621000016 beta-clamp/translesion DNA polymerase binding surface; other site 272621000017 S4 domain; Region: S4_2; pfam13275 272621000018 recombination protein F; Reviewed; Region: recF; PRK00064 272621000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 272621000020 Walker A/P-loop; other site 272621000021 ATP binding site [chemical binding]; other site 272621000022 Q-loop/lid; other site 272621000023 ABC transporter signature motif; other site 272621000024 Walker B; other site 272621000025 D-loop; other site 272621000026 H-loop/switch region; other site 272621000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 272621000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272621000029 ATP binding site [chemical binding]; other site 272621000030 Mg2+ binding site [ion binding]; other site 272621000031 G-X-G motif; other site 272621000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272621000033 anchoring element; other site 272621000034 dimer interface [polypeptide binding]; other site 272621000035 ATP binding site [chemical binding]; other site 272621000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 272621000037 active site 272621000038 putative metal-binding site [ion binding]; other site 272621000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272621000040 DNA gyrase subunit A; Validated; Region: PRK05560 272621000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272621000042 CAP-like domain; other site 272621000043 active site 272621000044 primary dimer interface [polypeptide binding]; other site 272621000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272621000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272621000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272621000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272621000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272621000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272621000051 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 272621000052 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272621000053 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272621000054 dimer interface [polypeptide binding]; other site 272621000055 ssDNA binding site [nucleotide binding]; other site 272621000056 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272621000057 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 272621000058 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 272621000059 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 272621000060 DHH family; Region: DHH; pfam01368 272621000061 DHHA1 domain; Region: DHHA1; pfam02272 272621000062 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 272621000063 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 272621000064 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 272621000065 replicative DNA helicase; Region: DnaB; TIGR00665 272621000066 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 272621000067 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 272621000068 Walker A motif; other site 272621000069 ATP binding site [chemical binding]; other site 272621000070 Walker B motif; other site 272621000071 DNA binding loops [nucleotide binding] 272621000072 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 272621000073 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272621000074 substrate binding pocket [chemical binding]; other site 272621000075 membrane-bound complex binding site; other site 272621000076 hinge residues; other site 272621000077 EDD domain protein, DegV family; Region: DegV; TIGR00762 272621000078 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272621000079 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272621000080 nucleotide binding site [chemical binding]; other site 272621000081 CsbD-like; Region: CsbD; pfam05532 272621000082 Yeast cortical protein KAR9; Region: KAR9; pfam08580 272621000083 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 272621000084 Cadmium resistance transporter; Region: Cad; pfam03596 272621000085 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272621000086 dimerization interface [polypeptide binding]; other site 272621000087 putative DNA binding site [nucleotide binding]; other site 272621000088 putative Zn2+ binding site [ion binding]; other site 272621000089 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272621000090 Plasmid replication protein; Region: Rep_2; pfam01719 272621000091 RNA helicase; Region: RNA_helicase; pfam00910 272621000092 Helix-turn-helix domain; Region: HTH_17; pfam12728 272621000093 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272621000094 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272621000095 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 272621000096 Fic/DOC family; Region: Fic; cl00960 272621000097 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 272621000098 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 272621000099 Peptidase family C69; Region: Peptidase_C69; pfam03577 272621000100 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 272621000101 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 272621000102 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 272621000103 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 272621000104 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 272621000105 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 272621000106 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272621000107 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 272621000108 catalytic triad [active] 272621000109 oxyanion hole [active] 272621000110 active site 272621000111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272621000112 putative substrate translocation pore; other site 272621000113 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272621000114 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 272621000115 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272621000116 Walker A/P-loop; other site 272621000117 ATP binding site [chemical binding]; other site 272621000118 Q-loop/lid; other site 272621000119 ABC transporter signature motif; other site 272621000120 Walker B; other site 272621000121 D-loop; other site 272621000122 H-loop/switch region; other site 272621000123 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 272621000124 TM-ABC transporter signature motif; other site 272621000125 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 272621000126 zinc binding site [ion binding]; other site 272621000127 putative ligand binding site [chemical binding]; other site 272621000128 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272621000129 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 272621000130 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272621000131 motif II; other site 272621000132 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 272621000133 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 272621000134 G1 box; other site 272621000135 putative GEF interaction site [polypeptide binding]; other site 272621000136 GTP/Mg2+ binding site [chemical binding]; other site 272621000137 Switch I region; other site 272621000138 G2 box; other site 272621000139 G3 box; other site 272621000140 Switch II region; other site 272621000141 G4 box; other site 272621000142 G5 box; other site 272621000143 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 272621000144 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272621000145 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 272621000146 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 272621000147 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272621000148 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272621000149 active site 272621000150 motif I; other site 272621000151 motif II; other site 272621000152 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272621000153 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 272621000154 putative catalytic site [active] 272621000155 putative metal binding site [ion binding]; other site 272621000156 putative phosphate binding site [ion binding]; other site 272621000157 D-lactate dehydrogenase; Validated; Region: PRK08605 272621000158 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 272621000159 homodimer interface [polypeptide binding]; other site 272621000160 ligand binding site [chemical binding]; other site 272621000161 NAD binding site [chemical binding]; other site 272621000162 catalytic site [active] 272621000163 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 272621000164 active site 272621000165 putative catalytic site [active] 272621000166 DNA binding site [nucleotide binding] 272621000167 putative phosphate binding site [ion binding]; other site 272621000168 metal binding site A [ion binding]; metal-binding site 272621000169 AP binding site [nucleotide binding]; other site 272621000170 metal binding site B [ion binding]; metal-binding site 272621000171 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 272621000172 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 272621000173 PLD-like domain; Region: PLDc_2; pfam13091 272621000174 putative homodimer interface [polypeptide binding]; other site 272621000175 putative active site [active] 272621000176 catalytic site [active] 272621000177 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272621000178 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272621000179 ATP binding site [chemical binding]; other site 272621000180 putative Mg++ binding site [ion binding]; other site 272621000181 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272621000182 nucleotide binding region [chemical binding]; other site 272621000183 ATP-binding site [chemical binding]; other site 272621000184 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 272621000185 Beta-lactamase; Region: Beta-lactamase; pfam00144 272621000186 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272621000187 active site 272621000188 catalytic residues [active] 272621000189 metal binding site [ion binding]; metal-binding site 272621000190 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 272621000191 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272621000192 L-aspartate oxidase; Provisional; Region: PRK06175 272621000193 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272621000194 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272621000195 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272621000196 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 272621000197 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272621000198 putative acyl-acceptor binding pocket; other site 272621000199 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 272621000200 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 272621000201 Ligand binding site; other site 272621000202 metal-binding site 272621000203 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 272621000204 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 272621000205 Ligand binding site; other site 272621000206 metal-binding site 272621000207 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 272621000208 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272621000209 active site 272621000210 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 272621000211 putative acyl-acceptor binding pocket; other site 272621000212 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272621000213 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272621000214 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 272621000215 Walker A/P-loop; other site 272621000216 ATP binding site [chemical binding]; other site 272621000217 Q-loop/lid; other site 272621000218 ABC transporter signature motif; other site 272621000219 Walker B; other site 272621000220 D-loop; other site 272621000221 H-loop/switch region; other site 272621000222 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 272621000223 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272621000224 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 272621000225 Walker A/P-loop; other site 272621000226 ATP binding site [chemical binding]; other site 272621000227 Q-loop/lid; other site 272621000228 ABC transporter signature motif; other site 272621000229 Walker B; other site 272621000230 D-loop; other site 272621000231 H-loop/switch region; other site 272621000232 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272621000233 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272621000234 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272621000235 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272621000236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272621000237 active site 272621000238 phosphorylation site [posttranslational modification] 272621000239 intermolecular recognition site; other site 272621000240 dimerization interface [polypeptide binding]; other site 272621000241 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272621000242 DNA binding site [nucleotide binding] 272621000243 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 272621000244 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272621000245 dimerization interface [polypeptide binding]; other site 272621000246 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272621000247 putative active site [active] 272621000248 heme pocket [chemical binding]; other site 272621000249 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272621000250 dimer interface [polypeptide binding]; other site 272621000251 phosphorylation site [posttranslational modification] 272621000252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272621000253 ATP binding site [chemical binding]; other site 272621000254 Mg2+ binding site [ion binding]; other site 272621000255 G-X-G motif; other site 272621000256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 272621000257 YycH protein; Region: YycH; pfam07435 272621000258 YycH protein; Region: YycI; pfam09648 272621000259 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 272621000260 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272621000261 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272621000262 protein binding site [polypeptide binding]; other site 272621000263 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 272621000264 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272621000265 non-specific DNA binding site [nucleotide binding]; other site 272621000266 salt bridge; other site 272621000267 sequence-specific DNA binding site [nucleotide binding]; other site 272621000268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 272621000269 CAAX protease self-immunity; Region: Abi; pfam02517 272621000270 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 272621000271 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272621000272 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 272621000273 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272621000274 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272621000275 Walker A/P-loop; other site 272621000276 ATP binding site [chemical binding]; other site 272621000277 Q-loop/lid; other site 272621000278 ABC transporter signature motif; other site 272621000279 Walker B; other site 272621000280 D-loop; other site 272621000281 H-loop/switch region; other site 272621000282 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 272621000283 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272621000284 Walker A/P-loop; other site 272621000285 ATP binding site [chemical binding]; other site 272621000286 Q-loop/lid; other site 272621000287 ABC transporter signature motif; other site 272621000288 Walker B; other site 272621000289 D-loop; other site 272621000290 H-loop/switch region; other site 272621000291 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272621000292 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272621000293 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272621000294 heat shock protein HtpX; Provisional; Region: PRK04897 272621000295 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 272621000296 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 272621000297 transmembrane helices; other site 272621000298 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; pfam01521 272621000299 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 272621000300 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 272621000301 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 272621000302 putative active site [active] 272621000303 catalytic site [active] 272621000304 putative metal binding site [ion binding]; other site 272621000305 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 272621000306 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272621000307 Zn2+ binding site [ion binding]; other site 272621000308 Mg2+ binding site [ion binding]; other site 272621000309 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272621000310 active site 272621000311 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 272621000312 Protein of unknown function (DUF805); Region: DUF805; pfam05656 272621000313 Protein of unknown function (DUF805); Region: DUF805; pfam05656 272621000314 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272621000315 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272621000316 Walker A/P-loop; other site 272621000317 ATP binding site [chemical binding]; other site 272621000318 Q-loop/lid; other site 272621000319 ABC transporter signature motif; other site 272621000320 Walker B; other site 272621000321 D-loop; other site 272621000322 H-loop/switch region; other site 272621000323 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272621000324 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272621000325 substrate binding pocket [chemical binding]; other site 272621000326 membrane-bound complex binding site; other site 272621000327 hinge residues; other site 272621000328 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 272621000329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272621000330 dimer interface [polypeptide binding]; other site 272621000331 conserved gate region; other site 272621000332 putative PBP binding loops; other site 272621000333 ABC-ATPase subunit interface; other site 272621000334 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 272621000335 active site 272621000336 DNA binding site [nucleotide binding] 272621000337 Protein of unknown function, DUF488; Region: DUF488; cl01246 272621000338 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 272621000339 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 272621000340 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 272621000341 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 272621000342 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 272621000343 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 272621000344 putative active site [active] 272621000345 catalytic site [active] 272621000346 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 272621000347 putative active site [active] 272621000348 catalytic site [active] 272621000349 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272621000350 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 272621000351 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 272621000352 RNA/DNA hybrid binding site [nucleotide binding]; other site 272621000353 active site 272621000354 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 272621000355 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272621000356 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272621000357 active site 272621000358 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 272621000359 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272621000360 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272621000361 non-specific DNA binding site [nucleotide binding]; other site 272621000362 salt bridge; other site 272621000363 sequence-specific DNA binding site [nucleotide binding]; other site 272621000364 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272621000365 Transposase; Region: HTH_Tnp_1; cl17663 272621000366 HTH-like domain; Region: HTH_21; pfam13276 272621000367 Integrase core domain; Region: rve; pfam00665 272621000368 Divergent AAA domain; Region: AAA_4; pfam04326 272621000369 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 272621000370 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 272621000371 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272621000372 active site 272621000373 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272621000374 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272621000375 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272621000376 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272621000377 substrate binding pocket [chemical binding]; other site 272621000378 membrane-bound complex binding site; other site 272621000379 hinge residues; other site 272621000380 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 272621000381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272621000382 dimer interface [polypeptide binding]; other site 272621000383 conserved gate region; other site 272621000384 putative PBP binding loops; other site 272621000385 ABC-ATPase subunit interface; other site 272621000386 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272621000387 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272621000388 Walker A/P-loop; other site 272621000389 ATP binding site [chemical binding]; other site 272621000390 Q-loop/lid; other site 272621000391 ABC transporter signature motif; other site 272621000392 Walker B; other site 272621000393 D-loop; other site 272621000394 H-loop/switch region; other site 272621000395 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 272621000396 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 272621000397 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 272621000398 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272621000399 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 272621000400 DNA binding residues [nucleotide binding] 272621000401 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 272621000402 YibE/F-like protein; Region: YibE_F; pfam07907 272621000403 YibE/F-like protein; Region: YibE_F; pfam07907 272621000404 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 272621000405 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272621000406 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 272621000407 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 272621000408 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 272621000409 active site 272621000410 catalytic site [active] 272621000411 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 272621000412 Interdomain contacts; other site 272621000413 Cytokine receptor motif; other site 272621000414 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl19067 272621000415 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 272621000416 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 272621000417 active site 272621000418 dimer interface [polypeptide binding]; other site 272621000419 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 272621000420 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 272621000421 active site 272621000422 phosphorylation site [posttranslational modification] 272621000423 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 272621000424 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 272621000425 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 272621000426 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272621000427 Ligand Binding Site [chemical binding]; other site 272621000428 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 272621000429 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 272621000430 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 272621000431 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 272621000432 Walker A/P-loop; other site 272621000433 ATP binding site [chemical binding]; other site 272621000434 Q-loop/lid; other site 272621000435 ABC transporter signature motif; other site 272621000436 Walker B; other site 272621000437 D-loop; other site 272621000438 H-loop/switch region; other site 272621000439 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 272621000440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272621000441 dimer interface [polypeptide binding]; other site 272621000442 conserved gate region; other site 272621000443 putative PBP binding loops; other site 272621000444 ABC-ATPase subunit interface; other site 272621000445 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 272621000446 OPT oligopeptide transporter protein; Region: OPT; cl14607 272621000447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272621000448 dimer interface [polypeptide binding]; other site 272621000449 conserved gate region; other site 272621000450 putative PBP binding loops; other site 272621000451 ABC-ATPase subunit interface; other site 272621000452 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 272621000453 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 272621000454 active site 272621000455 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 272621000456 dimer interface [polypeptide binding]; other site 272621000457 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 272621000458 Ligand Binding Site [chemical binding]; other site 272621000459 Molecular Tunnel; other site 272621000460 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 272621000461 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272621000462 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 272621000463 ATP cone domain; Region: ATP-cone; pfam03477 272621000464 Class III ribonucleotide reductase; Region: RNR_III; cd01675 272621000465 effector binding site; other site 272621000466 active site 272621000467 Zn binding site [ion binding]; other site 272621000468 glycine loop; other site 272621000469 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 272621000470 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 272621000471 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 272621000472 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 272621000473 Uncharacterized conserved protein [Function unknown]; Region: COG2461 272621000474 Family of unknown function (DUF438); Region: DUF438; pfam04282 272621000475 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 272621000476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272621000477 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272621000478 putative substrate translocation pore; other site 272621000479 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 272621000480 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 272621000481 active site 272621000482 Zn binding site [ion binding]; other site 272621000483 K+ potassium transporter; Region: K_trans; pfam02705 272621000484 Bacterial surface layer protein; Region: SLAP; pfam03217 272621000485 6-pyruvoyl tetrahydropterin synthase-related domain; Region: 6_pyr_pter_rel; TIGR03112 272621000486 putative glycosyltransferase, exosortase G-associated; Region: glyc2_xrt_Gpos1; TIGR03111 272621000487 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 272621000488 DXD motif; other site 272621000489 exosortase family protein XrtG; Region: exosort_Gpos; TIGR03110 272621000490 Bacterial surface layer protein; Region: SLAP; pfam03217 272621000491 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 272621000492 Bacterial surface layer protein; Region: SLAP; pfam03217 272621000493 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 272621000494 amidase catalytic site [active] 272621000495 Zn binding residues [ion binding]; other site 272621000496 substrate binding site [chemical binding]; other site 272621000497 Bacterial surface layer protein; Region: SLAP; pfam03217 272621000498 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 272621000499 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 272621000500 TrkA-N domain; Region: TrkA_N; pfam02254 272621000501 TrkA-C domain; Region: TrkA_C; pfam02080 272621000502 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272621000503 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272621000504 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272621000505 catalytic core [active] 272621000506 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 272621000507 putative substrate binding pocket [chemical binding]; other site 272621000508 AC domain interface; other site 272621000509 catalytic triad [active] 272621000510 AB domain interface; other site 272621000511 interchain disulfide; other site 272621000512 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 272621000513 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 272621000514 membrane protein; Provisional; Region: PRK14411 272621000515 Sulfatase; Region: Sulfatase; cl19157 272621000516 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 272621000517 Interdomain contacts; other site 272621000518 Cytokine receptor motif; other site 272621000519 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 272621000520 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 272621000521 active site 272621000522 HIGH motif; other site 272621000523 dimer interface [polypeptide binding]; other site 272621000524 KMSKS motif; other site 272621000525 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272621000526 RNA binding surface [nucleotide binding]; other site 272621000527 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 272621000528 trimer interface [polypeptide binding]; other site 272621000529 active site 272621000530 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 272621000531 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272621000532 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272621000533 peptide binding site [polypeptide binding]; other site 272621000534 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272621000535 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272621000536 peptide binding site [polypeptide binding]; other site 272621000537 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 272621000538 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 272621000539 active site 272621000540 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272621000541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272621000542 dimer interface [polypeptide binding]; other site 272621000543 conserved gate region; other site 272621000544 putative PBP binding loops; other site 272621000545 ABC-ATPase subunit interface; other site 272621000546 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272621000547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272621000548 dimer interface [polypeptide binding]; other site 272621000549 conserved gate region; other site 272621000550 putative PBP binding loops; other site 272621000551 ABC-ATPase subunit interface; other site 272621000552 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272621000553 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272621000554 Walker A/P-loop; other site 272621000555 ATP binding site [chemical binding]; other site 272621000556 Q-loop/lid; other site 272621000557 ABC transporter signature motif; other site 272621000558 Walker B; other site 272621000559 D-loop; other site 272621000560 H-loop/switch region; other site 272621000561 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 272621000562 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 272621000563 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272621000564 Walker A/P-loop; other site 272621000565 ATP binding site [chemical binding]; other site 272621000566 Q-loop/lid; other site 272621000567 ABC transporter signature motif; other site 272621000568 Walker B; other site 272621000569 D-loop; other site 272621000570 H-loop/switch region; other site 272621000571 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272621000572 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 272621000573 trimer interface [polypeptide binding]; other site 272621000574 active site 272621000575 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272621000576 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 272621000577 putative dimer interface [polypeptide binding]; other site 272621000578 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 272621000579 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 272621000580 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272621000581 CAAX protease self-immunity; Region: Abi; pfam02517 272621000582 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 272621000583 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 272621000584 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 272621000585 active site 272621000586 HIGH motif; other site 272621000587 dimer interface [polypeptide binding]; other site 272621000588 KMSKS motif; other site 272621000589 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 272621000590 catalytic motif [active] 272621000591 Zn binding site [ion binding]; other site 272621000592 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; cl01535 272621000593 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 272621000594 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 272621000595 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272621000596 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272621000597 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272621000598 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 272621000599 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 272621000600 active site 272621000601 HIGH motif; other site 272621000602 KMSKS motif; other site 272621000603 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 272621000604 tRNA binding surface [nucleotide binding]; other site 272621000605 anticodon binding site; other site 272621000606 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 272621000607 dimer interface [polypeptide binding]; other site 272621000608 putative tRNA-binding site [nucleotide binding]; other site 272621000609 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 272621000610 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 272621000611 active site 272621000612 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 272621000613 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 272621000614 putative active site [active] 272621000615 putative metal binding site [ion binding]; other site 272621000616 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 272621000617 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 272621000618 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 272621000619 pur operon repressor; Provisional; Region: PRK09213 272621000620 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 272621000621 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272621000622 active site 272621000623 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 272621000624 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 272621000625 Substrate binding site; other site 272621000626 Mg++ binding site; other site 272621000627 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 272621000628 active site 272621000629 substrate binding site [chemical binding]; other site 272621000630 CoA binding site [chemical binding]; other site 272621000631 Bacterial surface layer protein; Region: SLAP; pfam03217 272621000632 Bacterial surface layer protein; Region: SLAP; pfam03217 272621000633 Bacterial surface layer protein; Region: SLAP; pfam03217 272621000634 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 272621000635 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 272621000636 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 272621000637 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272621000638 active site 272621000639 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 272621000640 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 272621000641 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272621000642 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272621000643 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272621000644 putative active site [active] 272621000645 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272621000646 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272621000647 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272621000648 nucleotide binding site [chemical binding]; other site 272621000649 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 272621000650 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272621000651 Zn2+ binding site [ion binding]; other site 272621000652 Mg2+ binding site [ion binding]; other site 272621000653 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 272621000654 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 272621000655 CTP synthetase; Validated; Region: pyrG; PRK05380 272621000656 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 272621000657 Catalytic site [active] 272621000658 active site 272621000659 UTP binding site [chemical binding]; other site 272621000660 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 272621000661 active site 272621000662 putative oxyanion hole; other site 272621000663 catalytic triad [active] 272621000664 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 272621000665 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 272621000666 hinge; other site 272621000667 active site 272621000668 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272621000669 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272621000670 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272621000671 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 272621000672 Sulfate transporter family; Region: Sulfate_transp; cl19250 272621000673 xanthine permease; Region: pbuX; TIGR03173 272621000674 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272621000675 active site 272621000676 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272621000677 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272621000678 non-specific DNA binding site [nucleotide binding]; other site 272621000679 salt bridge; other site 272621000680 sequence-specific DNA binding site [nucleotide binding]; other site 272621000681 GMP synthase; Reviewed; Region: guaA; PRK00074 272621000682 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 272621000683 AMP/PPi binding site [chemical binding]; other site 272621000684 candidate oxyanion hole; other site 272621000685 catalytic triad [active] 272621000686 potential glutamine specificity residues [chemical binding]; other site 272621000687 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 272621000688 ATP Binding subdomain [chemical binding]; other site 272621000689 Ligand Binding sites [chemical binding]; other site 272621000690 Dimerization subdomain; other site 272621000691 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272621000692 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272621000693 Walker A/P-loop; other site 272621000694 ATP binding site [chemical binding]; other site 272621000695 Q-loop/lid; other site 272621000696 ABC transporter signature motif; other site 272621000697 Walker B; other site 272621000698 D-loop; other site 272621000699 H-loop/switch region; other site 272621000700 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 272621000701 LytTr DNA-binding domain; Region: LytTR; smart00850 272621000702 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272621000703 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272621000704 Coenzyme A binding pocket [chemical binding]; other site 272621000705 B3/4 domain; Region: B3_4; cl19243 272621000706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272621000707 putative substrate translocation pore; other site 272621000708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272621000709 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 272621000710 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272621000711 DNA binding site [nucleotide binding] 272621000712 active site 272621000713 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 272621000714 dimer interface [polypeptide binding]; other site 272621000715 active site 272621000716 glycine-pyridoxal phosphate binding site [chemical binding]; other site 272621000717 folate binding site [chemical binding]; other site 272621000718 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 272621000719 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 272621000720 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272621000721 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272621000722 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 272621000723 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 272621000724 Ca binding site [ion binding]; other site 272621000725 active site 272621000726 catalytic site [active] 272621000727 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 272621000728 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 272621000729 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272621000730 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272621000731 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272621000732 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272621000733 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272621000734 ATP binding site [chemical binding]; other site 272621000735 Mg++ binding site [ion binding]; other site 272621000736 motif III; other site 272621000737 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272621000738 nucleotide binding region [chemical binding]; other site 272621000739 ATP-binding site [chemical binding]; other site 272621000740 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 272621000741 alanine racemase; Reviewed; Region: alr; PRK00053 272621000742 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 272621000743 active site 272621000744 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272621000745 dimer interface [polypeptide binding]; other site 272621000746 substrate binding site [chemical binding]; other site 272621000747 catalytic residues [active] 272621000748 FOG: CBS domain [General function prediction only]; Region: COG0517 272621000749 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 272621000750 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 272621000751 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 272621000752 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272621000753 NAD binding site [chemical binding]; other site 272621000754 dimer interface [polypeptide binding]; other site 272621000755 substrate binding site [chemical binding]; other site 272621000756 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 272621000757 putative active site [active] 272621000758 catalytic residue [active] 272621000759 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 272621000760 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 272621000761 ABBA-type aromatic prenyltransferases (PTases); Region: ABBA-PTs; cl19121 272621000762 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 272621000763 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272621000764 ATP binding site [chemical binding]; other site 272621000765 putative Mg++ binding site [ion binding]; other site 272621000766 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272621000767 nucleotide binding region [chemical binding]; other site 272621000768 ATP-binding site [chemical binding]; other site 272621000769 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 272621000770 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272621000771 RNA binding surface [nucleotide binding]; other site 272621000772 Septum formation initiator; Region: DivIC; pfam04977 272621000773 S1 RNA binding domain; Region: S1; pfam00575 272621000774 RNA binding site [nucleotide binding]; other site 272621000775 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 272621000776 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 272621000777 Ligand Binding Site [chemical binding]; other site 272621000778 FtsH Extracellular; Region: FtsH_ext; pfam06480 272621000779 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 272621000780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272621000781 Walker A motif; other site 272621000782 ATP binding site [chemical binding]; other site 272621000783 Walker B motif; other site 272621000784 arginine finger; other site 272621000785 Peptidase family M41; Region: Peptidase_M41; pfam01434 272621000786 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 272621000787 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 272621000788 dimerization interface [polypeptide binding]; other site 272621000789 domain crossover interface; other site 272621000790 redox-dependent activation switch; other site 272621000791 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 272621000792 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 272621000793 FMN binding site [chemical binding]; other site 272621000794 active site 272621000795 catalytic residues [active] 272621000796 substrate binding site [chemical binding]; other site 272621000797 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 272621000798 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 272621000799 dimer interface [polypeptide binding]; other site 272621000800 putative anticodon binding site; other site 272621000801 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 272621000802 motif 1; other site 272621000803 active site 272621000804 motif 2; other site 272621000805 motif 3; other site 272621000806 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 272621000807 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 272621000808 Clp amino terminal domain; Region: Clp_N; pfam02861 272621000809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272621000810 Walker A motif; other site 272621000811 ATP binding site [chemical binding]; other site 272621000812 Walker B motif; other site 272621000813 arginine finger; other site 272621000814 UvrB/uvrC motif; Region: UVR; pfam02151 272621000815 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272621000816 Walker A motif; other site 272621000817 ATP binding site [chemical binding]; other site 272621000818 Walker B motif; other site 272621000819 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272621000820 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 272621000821 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 272621000822 RPB12 interaction site [polypeptide binding]; other site 272621000823 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 272621000824 RPB1 interaction site [polypeptide binding]; other site 272621000825 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 272621000826 RPB10 interaction site [polypeptide binding]; other site 272621000827 RPB11 interaction site [polypeptide binding]; other site 272621000828 RPB3 interaction site [polypeptide binding]; other site 272621000829 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 272621000830 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 272621000831 beta and beta' interface [polypeptide binding]; other site 272621000832 beta' and sigma factor interface [polypeptide binding]; other site 272621000833 Zn-binding [ion binding]; other site 272621000834 active site region [active] 272621000835 catalytic site [active] 272621000836 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 272621000837 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 272621000838 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 272621000839 G-loop; other site 272621000840 DNA binding site [nucleotide binding] 272621000841 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 272621000842 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 272621000843 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 272621000844 S17 interaction site [polypeptide binding]; other site 272621000845 S8 interaction site; other site 272621000846 16S rRNA interaction site [nucleotide binding]; other site 272621000847 streptomycin interaction site [chemical binding]; other site 272621000848 23S rRNA interaction site [nucleotide binding]; other site 272621000849 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 272621000850 30S ribosomal protein S7; Validated; Region: PRK05302 272621000851 elongation factor G; Reviewed; Region: PRK12739 272621000852 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 272621000853 G1 box; other site 272621000854 putative GEF interaction site [polypeptide binding]; other site 272621000855 GTP/Mg2+ binding site [chemical binding]; other site 272621000856 Switch I region; other site 272621000857 G2 box; other site 272621000858 G3 box; other site 272621000859 Switch II region; other site 272621000860 G4 box; other site 272621000861 G5 box; other site 272621000862 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 272621000863 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272621000864 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 272621000865 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 272621000866 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 272621000867 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 272621000868 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 272621000869 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 272621000870 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 272621000871 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 272621000872 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 272621000873 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 272621000874 putative translocon binding site; other site 272621000875 protein-rRNA interface [nucleotide binding]; other site 272621000876 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 272621000877 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 272621000878 G-X-X-G motif; other site 272621000879 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 272621000880 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 272621000881 23S rRNA interface [nucleotide binding]; other site 272621000882 5S rRNA interface [nucleotide binding]; other site 272621000883 putative antibiotic binding site [chemical binding]; other site 272621000884 L25 interface [polypeptide binding]; other site 272621000885 L27 interface [polypeptide binding]; other site 272621000886 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 272621000887 23S rRNA interface [nucleotide binding]; other site 272621000888 putative translocon interaction site; other site 272621000889 signal recognition particle (SRP54) interaction site; other site 272621000890 L23 interface [polypeptide binding]; other site 272621000891 trigger factor interaction site; other site 272621000892 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 272621000893 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 272621000894 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 272621000895 RNA binding site [nucleotide binding]; other site 272621000896 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 272621000897 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 272621000898 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 272621000899 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 272621000900 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 272621000901 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 272621000902 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272621000903 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272621000904 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 272621000905 23S rRNA interface [nucleotide binding]; other site 272621000906 L21e interface [polypeptide binding]; other site 272621000907 5S rRNA interface [nucleotide binding]; other site 272621000908 L27 interface [polypeptide binding]; other site 272621000909 L5 interface [polypeptide binding]; other site 272621000910 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 272621000911 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 272621000912 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 272621000913 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 272621000914 23S rRNA binding site [nucleotide binding]; other site 272621000915 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 272621000916 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 272621000917 SecY translocase; Region: SecY; pfam00344 272621000918 adenylate kinase; Reviewed; Region: adk; PRK00279 272621000919 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 272621000920 AMP-binding site [chemical binding]; other site 272621000921 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 272621000922 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 272621000923 rRNA binding site [nucleotide binding]; other site 272621000924 predicted 30S ribosome binding site; other site 272621000925 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 272621000926 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 272621000927 30S ribosomal protein S11; Validated; Region: PRK05309 272621000928 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 272621000929 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 272621000930 alphaNTD homodimer interface [polypeptide binding]; other site 272621000931 alphaNTD - beta interaction site [polypeptide binding]; other site 272621000932 alphaNTD - beta' interaction site [polypeptide binding]; other site 272621000933 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 272621000934 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 272621000935 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13640 272621000936 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272621000937 Walker A/P-loop; other site 272621000938 ATP binding site [chemical binding]; other site 272621000939 Q-loop/lid; other site 272621000940 ABC transporter signature motif; other site 272621000941 Walker B; other site 272621000942 D-loop; other site 272621000943 H-loop/switch region; other site 272621000944 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13641 272621000945 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272621000946 Walker A/P-loop; other site 272621000947 ATP binding site [chemical binding]; other site 272621000948 Q-loop/lid; other site 272621000949 ABC transporter signature motif; other site 272621000950 Walker B; other site 272621000951 D-loop; other site 272621000952 H-loop/switch region; other site 272621000953 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 272621000954 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 272621000955 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 272621000956 dimerization interface 3.5A [polypeptide binding]; other site 272621000957 active site 272621000958 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 272621000959 23S rRNA interface [nucleotide binding]; other site 272621000960 L3 interface [polypeptide binding]; other site 272621000961 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 272621000962 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272621000963 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272621000964 active site 272621000965 DNA binding site [nucleotide binding] 272621000966 Int/Topo IB signature motif; other site 272621000967 Plasmid replication protein; Region: Rep_2; pfam01719 272621000968 RNA helicase; Region: RNA_helicase; pfam00910 272621000969 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272621000970 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 272621000971 YjcQ protein; Region: YjcQ; pfam09639 272621000972 DJ-1 family protein; Region: not_thiJ; TIGR01383 272621000973 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 272621000974 conserved cys residue [active] 272621000975 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 272621000976 HAD-hyrolase-like; Region: Hydrolase_like; cl19142 272621000977 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272621000978 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272621000979 catalytic core [active] 272621000980 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 272621000981 Phosphoglycerate mutase family; Region: PGAM; smart00855 272621000982 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272621000983 AAA domain; Region: AAA_17; cl19128 272621000984 AAA domain; Region: AAA_33; pfam13671 272621000985 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 272621000986 trimer interface [polypeptide binding]; other site 272621000987 active site 272621000988 G bulge; other site 272621000989 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272621000990 trimer interface [polypeptide binding]; other site 272621000991 active site 272621000992 DNA repair protein RadA; Provisional; Region: PRK11823 272621000993 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 272621000994 Walker A motif/ATP binding site; other site 272621000995 ATP binding site [chemical binding]; other site 272621000996 Walker B motif; other site 272621000997 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 272621000998 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 272621000999 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272621001000 active site 272621001001 HIGH motif; other site 272621001002 KMSKS motif; other site 272621001003 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 272621001004 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 272621001005 active site 272621001006 HIGH motif; other site 272621001007 KMSKS motif; other site 272621001008 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272621001009 tRNA binding surface [nucleotide binding]; other site 272621001010 anticodon binding site; other site 272621001011 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 272621001012 active site 272621001013 metal binding site [ion binding]; metal-binding site 272621001014 dimerization interface [polypeptide binding]; other site 272621001015 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 272621001016 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 272621001017 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272621001018 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 272621001019 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 272621001020 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 272621001021 N- and C-terminal domain interface [polypeptide binding]; other site 272621001022 active site 272621001023 catalytic site [active] 272621001024 metal binding site [ion binding]; metal-binding site 272621001025 carbohydrate binding site [chemical binding]; other site 272621001026 ATP binding site [chemical binding]; other site 272621001027 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272621001028 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 272621001029 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 272621001030 TPP-binding site; other site 272621001031 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272621001032 PYR/PP interface [polypeptide binding]; other site 272621001033 dimer interface [polypeptide binding]; other site 272621001034 TPP binding site [chemical binding]; other site 272621001035 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272621001036 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 272621001037 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 272621001038 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 272621001039 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 272621001040 putative homodimer interface [polypeptide binding]; other site 272621001041 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 272621001042 heterodimer interface [polypeptide binding]; other site 272621001043 homodimer interface [polypeptide binding]; other site 272621001044 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 272621001045 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 272621001046 23S rRNA interface [nucleotide binding]; other site 272621001047 L7/L12 interface [polypeptide binding]; other site 272621001048 putative thiostrepton binding site; other site 272621001049 L25 interface [polypeptide binding]; other site 272621001050 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 272621001051 mRNA/rRNA interface [nucleotide binding]; other site 272621001052 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 272621001053 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 272621001054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272621001055 dimer interface [polypeptide binding]; other site 272621001056 conserved gate region; other site 272621001057 putative PBP binding loops; other site 272621001058 ABC-ATPase subunit interface; other site 272621001059 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 272621001060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272621001061 dimer interface [polypeptide binding]; other site 272621001062 conserved gate region; other site 272621001063 putative PBP binding loops; other site 272621001064 ABC-ATPase subunit interface; other site 272621001065 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 272621001066 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 272621001067 Walker A/P-loop; other site 272621001068 ATP binding site [chemical binding]; other site 272621001069 Q-loop/lid; other site 272621001070 ABC transporter signature motif; other site 272621001071 Walker B; other site 272621001072 D-loop; other site 272621001073 H-loop/switch region; other site 272621001074 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14251 272621001075 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 272621001076 Walker A/P-loop; other site 272621001077 ATP binding site [chemical binding]; other site 272621001078 Q-loop/lid; other site 272621001079 ABC transporter signature motif; other site 272621001080 Walker B; other site 272621001081 D-loop; other site 272621001082 H-loop/switch region; other site 272621001083 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 272621001084 PhoU domain; Region: PhoU; pfam01895 272621001085 PhoU domain; Region: PhoU; pfam01895 272621001086 Membrane transport protein; Region: Mem_trans; cl09117 272621001087 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 272621001088 23S rRNA interface [nucleotide binding]; other site 272621001089 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 272621001090 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 272621001091 core dimer interface [polypeptide binding]; other site 272621001092 peripheral dimer interface [polypeptide binding]; other site 272621001093 L10 interface [polypeptide binding]; other site 272621001094 L11 interface [polypeptide binding]; other site 272621001095 putative EF-Tu interaction site [polypeptide binding]; other site 272621001096 putative EF-G interaction site [polypeptide binding]; other site 272621001097 Ion channel; Region: Ion_trans_2; pfam07885 272621001098 Protein of unknown function (DUF904); Region: DUF904; pfam06005 272621001099 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272621001100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272621001101 S-adenosylmethionine binding site [chemical binding]; other site 272621001102 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 272621001103 nucleoside/Zn binding site; other site 272621001104 dimer interface [polypeptide binding]; other site 272621001105 catalytic motif [active] 272621001106 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 272621001107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272621001108 Walker A motif; other site 272621001109 ATP binding site [chemical binding]; other site 272621001110 DNA polymerase III subunit delta'; Validated; Region: PRK08485 272621001111 Walker B motif; other site 272621001112 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 272621001113 Probable transposase; Region: OrfB_IS605; pfam01385 272621001114 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 272621001115 hypothetical protein; Validated; Region: PRK00153 272621001116 recombination protein RecR; Reviewed; Region: recR; PRK00076 272621001117 RecR protein; Region: RecR; pfam02132 272621001118 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 272621001119 putative active site [active] 272621001120 putative metal-binding site [ion binding]; other site 272621001121 tetramer interface [polypeptide binding]; other site 272621001122 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 272621001123 thymidylate kinase; Validated; Region: tmk; PRK00698 272621001124 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 272621001125 TMP-binding site; other site 272621001126 ATP-binding site [chemical binding]; other site 272621001127 Protein of unknown function (DUF970); Region: DUF970; cl17525 272621001128 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 272621001129 DNA polymerase III subunit delta'; Validated; Region: PRK08485 272621001130 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 272621001131 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 272621001132 putative SAM binding site [chemical binding]; other site 272621001133 putative homodimer interface [polypeptide binding]; other site 272621001134 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 272621001135 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 272621001136 active site 272621001137 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 272621001138 active site 2 [active] 272621001139 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 272621001140 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 272621001141 Glycoprotease family; Region: Peptidase_M22; pfam00814 272621001142 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 272621001143 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272621001144 Coenzyme A binding pocket [chemical binding]; other site 272621001145 UGMP family protein; Validated; Region: PRK09604 272621001146 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 272621001147 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 272621001148 intersubunit interface [polypeptide binding]; other site 272621001149 active site 272621001150 catalytic residue [active] 272621001151 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272621001152 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272621001153 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272621001154 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272621001155 DNA-binding site [nucleotide binding]; DNA binding site 272621001156 UTRA domain; Region: UTRA; pfam07702 272621001157 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 272621001158 formyl-CoA transferase; Region: oxalate_frc; TIGR03253 272621001159 oxalyl-CoA decarboxylase; Region: oxalate_oxc; TIGR03254 272621001160 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272621001161 PYR/PP interface [polypeptide binding]; other site 272621001162 dimer interface [polypeptide binding]; other site 272621001163 TPP binding site [chemical binding]; other site 272621001164 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272621001165 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 272621001166 TPP-binding site; other site 272621001167 dimer interface [polypeptide binding]; other site 272621001168 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272621001169 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272621001170 ABC transporter; Region: ABC_tran_2; pfam12848 272621001171 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272621001172 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 272621001173 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 272621001174 CoA binding domain; Region: CoA_binding; pfam02629 272621001175 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272621001176 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272621001177 DNA binding site [nucleotide binding] 272621001178 domain linker motif; other site 272621001179 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 272621001180 dimerization interface [polypeptide binding]; other site 272621001181 ligand binding site [chemical binding]; other site 272621001182 sodium binding site [ion binding]; other site 272621001183 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 272621001184 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 272621001185 substrate binding [chemical binding]; other site 272621001186 active site 272621001187 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 272621001188 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 272621001189 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272621001190 active site turn [active] 272621001191 phosphorylation site [posttranslational modification] 272621001192 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272621001193 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 272621001194 HPr interaction site; other site 272621001195 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272621001196 active site 272621001197 phosphorylation site [posttranslational modification] 272621001198 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 272621001199 LytTr DNA-binding domain; Region: LytTR; smart00850 272621001200 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 272621001201 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 272621001202 oligomerisation interface [polypeptide binding]; other site 272621001203 mobile loop; other site 272621001204 roof hairpin; other site 272621001205 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 272621001206 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 272621001207 ring oligomerisation interface [polypeptide binding]; other site 272621001208 ATP/Mg binding site [chemical binding]; other site 272621001209 stacking interactions; other site 272621001210 hinge regions; other site 272621001211 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 272621001212 MutS domain I; Region: MutS_I; pfam01624 272621001213 MutS domain II; Region: MutS_II; pfam05188 272621001214 MutS domain III; Region: MutS_III; pfam05192 272621001215 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 272621001216 Walker A/P-loop; other site 272621001217 ATP binding site [chemical binding]; other site 272621001218 Q-loop/lid; other site 272621001219 ABC transporter signature motif; other site 272621001220 Walker B; other site 272621001221 D-loop; other site 272621001222 H-loop/switch region; other site 272621001223 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 272621001224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272621001225 ATP binding site [chemical binding]; other site 272621001226 Mg2+ binding site [ion binding]; other site 272621001227 G-X-G motif; other site 272621001228 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 272621001229 ATP binding site [chemical binding]; other site 272621001230 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 272621001231 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 272621001232 RuvA N terminal domain; Region: RuvA_N; pfam01330 272621001233 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 272621001234 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 272621001235 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 272621001236 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272621001237 Walker A motif; other site 272621001238 ATP binding site [chemical binding]; other site 272621001239 Walker B motif; other site 272621001240 arginine finger; other site 272621001241 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 272621001242 Preprotein translocase subunit; Region: YajC; cl00806 272621001243 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 272621001244 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 272621001245 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 272621001246 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 272621001247 active site 272621001248 DNA polymerase IV; Validated; Region: PRK02406 272621001249 DNA binding site [nucleotide binding] 272621001250 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 272621001251 DHH family; Region: DHH; pfam01368 272621001252 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 272621001253 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272621001254 ATP binding site [chemical binding]; other site 272621001255 putative Mg++ binding site [ion binding]; other site 272621001256 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272621001257 nucleotide binding region [chemical binding]; other site 272621001258 ATP-binding site [chemical binding]; other site 272621001259 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 272621001260 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 272621001261 motif 1; other site 272621001262 active site 272621001263 motif 2; other site 272621001264 motif 3; other site 272621001265 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 272621001266 DHHA1 domain; Region: DHHA1; pfam02272 272621001267 hypothetical protein; Provisional; Region: PRK05473 272621001268 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 272621001269 hypothetical protein; Provisional; Region: PRK13678 272621001270 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 272621001271 MutS domain III; Region: MutS_III; pfam05192 272621001272 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 272621001273 Walker A/P-loop; other site 272621001274 ATP binding site [chemical binding]; other site 272621001275 Q-loop/lid; other site 272621001276 ABC transporter signature motif; other site 272621001277 Walker B; other site 272621001278 D-loop; other site 272621001279 H-loop/switch region; other site 272621001280 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 272621001281 Smr domain; Region: Smr; pfam01713 272621001282 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272621001283 catalytic residues [active] 272621001284 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 272621001285 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 272621001286 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 272621001287 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 272621001288 active site 272621001289 dimerization interface [polypeptide binding]; other site 272621001290 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 272621001291 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272621001292 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272621001293 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 272621001294 active site 272621001295 catabolite control protein A; Region: ccpA; TIGR01481 272621001296 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272621001297 DNA binding site [nucleotide binding] 272621001298 domain linker motif; other site 272621001299 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 272621001300 dimerization interface [polypeptide binding]; other site 272621001301 effector binding site; other site 272621001302 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 272621001303 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 272621001304 active site 272621001305 catalytic site [active] 272621001306 metal binding site [ion binding]; metal-binding site 272621001307 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 272621001308 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 272621001309 active site 272621001310 metal binding site [ion binding]; metal-binding site 272621001311 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272621001312 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 272621001313 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 272621001314 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272621001315 active site 272621001316 motif I; other site 272621001317 motif II; other site 272621001318 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 272621001319 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 272621001320 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 272621001321 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 272621001322 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272621001323 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 272621001324 active site 272621001325 8-oxo-dGMP binding site [chemical binding]; other site 272621001326 nudix motif; other site 272621001327 metal binding site [ion binding]; metal-binding site 272621001328 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 272621001329 PLD-like domain; Region: PLDc_2; pfam13091 272621001330 putative homodimer interface [polypeptide binding]; other site 272621001331 putative active site [active] 272621001332 catalytic site [active] 272621001333 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 272621001334 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272621001335 ATP binding site [chemical binding]; other site 272621001336 putative Mg++ binding site [ion binding]; other site 272621001337 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272621001338 nucleotide binding region [chemical binding]; other site 272621001339 ATP-binding site [chemical binding]; other site 272621001340 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 272621001341 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 272621001342 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272621001343 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 272621001344 putative ADP-binding pocket [chemical binding]; other site 272621001345 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272621001346 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; pfam13579 272621001347 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272621001348 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 272621001349 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 272621001350 Sulfatase; Region: Sulfatase; pfam00884 272621001351 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 272621001352 ribonuclease R; Region: RNase_R; TIGR02063 272621001353 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 272621001354 RNB domain; Region: RNB; pfam00773 272621001355 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 272621001356 RNA binding site [nucleotide binding]; other site 272621001357 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 272621001358 SmpB-tmRNA interface; other site 272621001359 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 272621001360 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 272621001361 active pocket/dimerization site; other site 272621001362 active site 272621001363 phosphorylation site [posttranslational modification] 272621001364 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 272621001365 active site 272621001366 phosphorylation site [posttranslational modification] 272621001367 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 272621001368 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 272621001369 Domain of unknown function (DUF956); Region: DUF956; pfam06115 272621001370 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272621001371 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272621001372 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272621001373 dimerization interface [polypeptide binding]; other site 272621001374 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 272621001375 putative trimer interface [polypeptide binding]; other site 272621001376 putative CoA binding site [chemical binding]; other site 272621001377 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 272621001378 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 272621001379 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 272621001380 putative catalytic cysteine [active] 272621001381 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 272621001382 putative active site [active] 272621001383 metal binding site [ion binding]; metal-binding site 272621001384 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 272621001385 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 272621001386 glutaminase active site [active] 272621001387 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 272621001388 dimer interface [polypeptide binding]; other site 272621001389 active site 272621001390 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 272621001391 dimer interface [polypeptide binding]; other site 272621001392 active site 272621001393 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 272621001394 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 272621001395 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 272621001396 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 272621001397 active site 272621001398 Ap4A binding cleft/pocket [chemical binding]; other site 272621001399 P4 phosphate binding site; other site 272621001400 nudix motif; other site 272621001401 putative P2/P3 phosphate binding site [ion binding]; other site 272621001402 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 272621001403 active site 272621001404 metal-binding site [ion binding] 272621001405 nucleotide-binding site [chemical binding]; other site 272621001406 TerB-N; Region: TerB-N; pfam13208 272621001407 TerB-C domain; Region: TerB-C; pfam15615 272621001408 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 272621001409 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 272621001410 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272621001411 ATP binding site [chemical binding]; other site 272621001412 putative Mg++ binding site [ion binding]; other site 272621001413 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272621001414 nucleotide binding region [chemical binding]; other site 272621001415 ATP-binding site [chemical binding]; other site 272621001416 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 272621001417 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 272621001418 dimer interface [polypeptide binding]; other site 272621001419 FMN binding site [chemical binding]; other site 272621001420 NADPH bind site [chemical binding]; other site 272621001421 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 272621001422 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272621001423 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272621001424 ATP binding site [chemical binding]; other site 272621001425 putative Mg++ binding site [ion binding]; other site 272621001426 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 272621001427 AAA ATPase domain; Region: AAA_15; pfam13175 272621001428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272621001429 Walker A/P-loop; other site 272621001430 ATP binding site [chemical binding]; other site 272621001431 AAA domain; Region: AAA_21; pfam13304 272621001432 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 272621001433 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 272621001434 Plasmid replication protein; Region: Rep_2; pfam01719 272621001435 RNA helicase; Region: RNA_helicase; pfam00910 272621001436 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272621001437 active site 272621001438 DNA binding site [nucleotide binding] 272621001439 Int/Topo IB signature motif; other site 272621001440 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; pfam01521 272621001441 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 272621001442 active site 272621001443 metal binding site [ion binding]; metal-binding site 272621001444 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272621001445 Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856 272621001446 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 272621001447 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272621001448 catalytic core [active] 272621001449 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272621001450 catalytic core [active] 272621001451 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 272621001452 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 272621001453 catalytic site [active] 272621001454 active site 272621001455 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272621001456 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272621001457 DNA binding site [nucleotide binding] 272621001458 domain linker motif; other site 272621001459 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 272621001460 dimerization interface [polypeptide binding]; other site 272621001461 ligand binding site [chemical binding]; other site 272621001462 sodium binding site [ion binding]; other site 272621001463 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272621001464 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272621001465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272621001466 dimer interface [polypeptide binding]; other site 272621001467 conserved gate region; other site 272621001468 putative PBP binding loops; other site 272621001469 ABC-ATPase subunit interface; other site 272621001470 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272621001471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272621001472 dimer interface [polypeptide binding]; other site 272621001473 conserved gate region; other site 272621001474 putative PBP binding loops; other site 272621001475 ABC-ATPase subunit interface; other site 272621001476 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 272621001477 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 272621001478 substrate binding [chemical binding]; other site 272621001479 active site 272621001480 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 272621001481 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 272621001482 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 272621001483 Walker A/P-loop; other site 272621001484 ATP binding site [chemical binding]; other site 272621001485 Q-loop/lid; other site 272621001486 ABC transporter signature motif; other site 272621001487 Walker B; other site 272621001488 D-loop; other site 272621001489 H-loop/switch region; other site 272621001490 TOBE domain; Region: TOBE_2; pfam08402 272621001491 sucrose phosphorylase; Provisional; Region: PRK13840 272621001492 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 272621001493 active site 272621001494 homodimer interface [polypeptide binding]; other site 272621001495 catalytic site [active] 272621001496 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 272621001497 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 272621001498 Bacterial surface layer protein; Region: SLAP; pfam03217 272621001499 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272621001500 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272621001501 DNA-binding site [nucleotide binding]; DNA binding site 272621001502 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 272621001503 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272621001504 active site 272621001505 nucleotide binding site [chemical binding]; other site 272621001506 HIGH motif; other site 272621001507 KMSKS motif; other site 272621001508 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 272621001509 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272621001510 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 272621001511 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 272621001512 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 272621001513 active site 272621001514 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 272621001515 homodimer interface [polypeptide binding]; other site 272621001516 NAD binding pocket [chemical binding]; other site 272621001517 ATP binding pocket [chemical binding]; other site 272621001518 Mg binding site [ion binding]; other site 272621001519 active-site loop [active] 272621001520 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272621001521 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 272621001522 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272621001523 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272621001524 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 272621001525 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272621001526 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 272621001527 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; cl19502 272621001528 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 272621001529 Polysaccharide biosynthesis protein; Region: Polysacc_synt; pfam01943 272621001530 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 272621001531 Polysaccharide biosynthesis C-terminal domain; Region: Polysacc_synt_C; pfam14667 272621001532 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; cl19952 272621001533 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 272621001534 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 272621001535 Part of AAA domain; Region: AAA_19; pfam13245 272621001536 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272621001537 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 272621001538 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 272621001539 nucleotide binding pocket [chemical binding]; other site 272621001540 K-X-D-G motif; other site 272621001541 catalytic site [active] 272621001542 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 272621001543 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 272621001544 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 272621001545 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 272621001546 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 272621001547 Dimer interface [polypeptide binding]; other site 272621001548 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 272621001549 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 272621001550 putative dimer interface [polypeptide binding]; other site 272621001551 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 272621001552 putative dimer interface [polypeptide binding]; other site 272621001553 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 272621001554 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 272621001555 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 272621001556 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 272621001557 GatB domain; Region: GatB_Yqey; smart00845 272621001558 putative lipid kinase; Reviewed; Region: PRK13337 272621001559 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 272621001560 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 272621001561 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 272621001562 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 272621001563 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 272621001564 TRAM domain; Region: TRAM; cl01282 272621001565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272621001566 S-adenosylmethionine binding site [chemical binding]; other site 272621001567 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 272621001568 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272621001569 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 272621001570 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272621001571 metal-binding site [ion binding] 272621001572 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272621001573 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272621001574 ligand binding site [chemical binding]; other site 272621001575 flexible hinge region; other site 272621001576 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 272621001577 non-specific DNA interactions [nucleotide binding]; other site 272621001578 DNA binding site [nucleotide binding] 272621001579 sequence specific DNA binding site [nucleotide binding]; other site 272621001580 putative cAMP binding site [chemical binding]; other site 272621001581 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 272621001582 putative uracil binding site [chemical binding]; other site 272621001583 putative active site [active] 272621001584 Recombinase; Region: Recombinase; pfam07508 272621001585 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 272621001586 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272621001587 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 272621001588 catalytic residues [active] 272621001589 catalytic nucleophile [active] 272621001590 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 272621001591 Phage portal protein; Region: Phage_portal; cl19194 272621001592 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272621001593 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272621001594 Coenzyme A binding pocket [chemical binding]; other site 272621001595 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272621001596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272621001597 putative substrate translocation pore; other site 272621001598 CAAX protease self-immunity; Region: Abi; pfam02517 272621001599 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272621001600 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 272621001601 myosin-cross-reactive antigen; Provisional; Region: PRK13977 272621001602 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; pfam06100 272621001603 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272621001604 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272621001605 Coenzyme A binding pocket [chemical binding]; other site 272621001606 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272621001607 active site 272621001608 catalytic tetrad [active] 272621001609 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272621001610 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272621001611 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272621001612 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272621001613 Walker A/P-loop; other site 272621001614 ATP binding site [chemical binding]; other site 272621001615 Q-loop/lid; other site 272621001616 ABC transporter signature motif; other site 272621001617 Sulfate transporter family; Region: Sulfate_transp; cl19250 272621001618 uracil-xanthine permease; Region: ncs2; TIGR00801 272621001619 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272621001620 active site 272621001621 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272621001622 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272621001623 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272621001624 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272621001625 active site 272621001626 motif I; other site 272621001627 motif II; other site 272621001628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272621001629 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272621001630 putative substrate translocation pore; other site 272621001631 drug efflux system protein MdtG; Provisional; Region: PRK09874 272621001632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272621001633 putative substrate translocation pore; other site 272621001634 Predicted permeases [General function prediction only]; Region: COG0679 272621001635 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 272621001636 oligomer interface [polypeptide binding]; other site 272621001637 active site 272621001638 metal binding site [ion binding]; metal-binding site 272621001639 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 272621001640 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272621001641 ABC transporter; Region: ABC_tran_2; pfam12848 272621001642 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272621001643 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272621001644 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272621001645 substrate binding pocket [chemical binding]; other site 272621001646 membrane-bound complex binding site; other site 272621001647 hinge residues; other site 272621001648 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 272621001649 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272621001650 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272621001651 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272621001652 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272621001653 Walker A/P-loop; other site 272621001654 ATP binding site [chemical binding]; other site 272621001655 Q-loop/lid; other site 272621001656 ABC transporter signature motif; other site 272621001657 Walker B; other site 272621001658 D-loop; other site 272621001659 H-loop/switch region; other site 272621001660 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272621001661 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272621001662 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272621001663 Walker A/P-loop; other site 272621001664 ATP binding site [chemical binding]; other site 272621001665 Q-loop/lid; other site 272621001666 ABC transporter signature motif; other site 272621001667 Walker B; other site 272621001668 D-loop; other site 272621001669 H-loop/switch region; other site 272621001670 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 272621001671 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 272621001672 ATP-binding site [chemical binding]; other site 272621001673 Sugar specificity; other site 272621001674 Pyrimidine base specificity; other site 272621001675 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272621001676 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272621001677 Walker A/P-loop; other site 272621001678 ATP binding site [chemical binding]; other site 272621001679 Q-loop/lid; other site 272621001680 ABC transporter signature motif; other site 272621001681 Walker B; other site 272621001682 D-loop; other site 272621001683 H-loop/switch region; other site 272621001684 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272621001685 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272621001686 substrate binding pocket [chemical binding]; other site 272621001687 membrane-bound complex binding site; other site 272621001688 hinge residues; other site 272621001689 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 272621001690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272621001691 dimer interface [polypeptide binding]; other site 272621001692 conserved gate region; other site 272621001693 putative PBP binding loops; other site 272621001694 ABC-ATPase subunit interface; other site 272621001695 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 272621001696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272621001697 dimer interface [polypeptide binding]; other site 272621001698 conserved gate region; other site 272621001699 putative PBP binding loops; other site 272621001700 ABC-ATPase subunit interface; other site 272621001701 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 272621001702 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272621001703 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 272621001704 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 272621001705 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 272621001706 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 272621001707 nucleotide binding site/active site [active] 272621001708 HIT family signature motif; other site 272621001709 catalytic residue [active] 272621001710 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 272621001711 substrate binding site [chemical binding]; other site 272621001712 dimer interface [polypeptide binding]; other site 272621001713 ATP binding site [chemical binding]; other site 272621001714 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 272621001715 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272621001716 active site 272621001717 dimer interface [polypeptide binding]; other site 272621001718 K+ potassium transporter; Region: K_trans; pfam02705 272621001719 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 272621001720 active site 272621001721 tetramer interface [polypeptide binding]; other site 272621001722 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272621001723 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272621001724 DNA-binding site [nucleotide binding]; DNA binding site 272621001725 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 272621001726 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272621001727 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272621001728 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 272621001729 Walker A/P-loop; other site 272621001730 ATP binding site [chemical binding]; other site 272621001731 Q-loop/lid; other site 272621001732 ABC transporter signature motif; other site 272621001733 Walker B; other site 272621001734 D-loop; other site 272621001735 H-loop/switch region; other site 272621001736 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272621001737 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 272621001738 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272621001739 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272621001740 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272621001741 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272621001742 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272621001743 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272621001744 Walker A/P-loop; other site 272621001745 ATP binding site [chemical binding]; other site 272621001746 Q-loop/lid; other site 272621001747 ABC transporter signature motif; other site 272621001748 Walker B; other site 272621001749 D-loop; other site 272621001750 H-loop/switch region; other site 272621001751 Enterocin A Immunity; Region: EntA_Immun; pfam08951 272621001752 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272621001753 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 272621001754 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272621001755 putative phosphoketolase; Provisional; Region: PRK05261 272621001756 XFP N-terminal domain; Region: XFP_N; pfam09364 272621001757 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 272621001758 XFP C-terminal domain; Region: XFP_C; pfam09363 272621001759 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 272621001760 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 272621001761 active site 272621001762 nucleophile elbow; other site 272621001763 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 272621001764 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 272621001765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272621001766 active site 272621001767 phosphorylation site [posttranslational modification] 272621001768 intermolecular recognition site; other site 272621001769 dimerization interface [polypeptide binding]; other site 272621001770 LytTr DNA-binding domain; Region: LytTR; pfam04397 272621001771 CAAX protease self-immunity; Region: Abi; pfam02517 272621001772 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272621001773 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272621001774 active site 272621001775 motif I; other site 272621001776 motif II; other site 272621001777 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272621001778 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 272621001779 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272621001780 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272621001781 active site turn [active] 272621001782 phosphorylation site [posttranslational modification] 272621001783 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 272621001784 active site turn [active] 272621001785 phosphorylation site [posttranslational modification] 272621001786 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272621001787 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272621001788 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272621001789 putative active site [active] 272621001790 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272621001791 HPr interaction site; other site 272621001792 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272621001793 active site 272621001794 phosphorylation site [posttranslational modification] 272621001795 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 272621001796 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 272621001797 putative FMN binding site [chemical binding]; other site 272621001798 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272621001799 Domain of unknown function DUF21; Region: DUF21; pfam01595 272621001800 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272621001801 Transporter associated domain; Region: CorC_HlyC; smart01091 272621001802 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272621001803 active site 272621001804 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272621001805 Transposase; Region: HTH_Tnp_1; cl17663 272621001806 HTH-like domain; Region: HTH_21; pfam13276 272621001807 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272621001808 Integrase core domain; Region: rve; pfam00665 272621001809 Integrase core domain; Region: rve_2; pfam13333 272621001810 amino acid transporter; Region: 2A0306; TIGR00909 272621001811 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 272621001812 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419 272621001813 active site 272621001814 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 272621001815 DEAD/DEAH box helicase; Region: DEAD; pfam00270 272621001816 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 272621001817 ATP binding site [chemical binding]; other site 272621001818 putative Mg++ binding site [ion binding]; other site 272621001819 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272621001820 nucleotide binding region [chemical binding]; other site 272621001821 ATP-binding site [chemical binding]; other site 272621001822 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272621001823 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 272621001824 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 272621001825 active site 272621001826 homodimer interface [polypeptide binding]; other site 272621001827 GtrA-like protein; Region: GtrA; pfam04138 272621001828 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272621001829 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 272621001830 active site 272621001831 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 272621001832 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 272621001833 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 272621001834 active site 272621001835 tetramer interface; other site 272621001836 putative acyltransferase; Provisional; Region: PRK05790 272621001837 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272621001838 dimer interface [polypeptide binding]; other site 272621001839 active site 272621001840 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 272621001841 homodimer interface [polypeptide binding]; other site 272621001842 catalytic residues [active] 272621001843 NAD binding site [chemical binding]; other site 272621001844 substrate binding pocket [chemical binding]; other site 272621001845 flexible flap; other site 272621001846 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 272621001847 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 272621001848 dimer interface [polypeptide binding]; other site 272621001849 active site 272621001850 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 272621001851 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272621001852 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272621001853 nucleophilic elbow; other site 272621001854 catalytic triad; other site 272621001855 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 272621001856 TRAM domain; Region: TRAM; pfam01938 272621001857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272621001858 S-adenosylmethionine binding site [chemical binding]; other site 272621001859 recombination regulator RecX; Provisional; Region: recX; PRK14135 272621001860 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 272621001861 FOG: CBS domain [General function prediction only]; Region: COG0517 272621001862 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272621001863 Transporter associated domain; Region: CorC_HlyC; pfam03471 272621001864 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 272621001865 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 272621001866 G1 box; other site 272621001867 putative GEF interaction site [polypeptide binding]; other site 272621001868 GTP/Mg2+ binding site [chemical binding]; other site 272621001869 Switch I region; other site 272621001870 G2 box; other site 272621001871 G3 box; other site 272621001872 Switch II region; other site 272621001873 G4 box; other site 272621001874 G5 box; other site 272621001875 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 272621001876 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272621001877 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 272621001878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272621001879 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272621001880 Walker A motif; other site 272621001881 ATP binding site [chemical binding]; other site 272621001882 Walker B motif; other site 272621001883 arginine finger; other site 272621001884 UvrB/uvrC motif; Region: UVR; pfam02151 272621001885 endopeptidase Clp ATP-binding regulatory subunit (clpX); Region: clpX; TIGR00382 272621001886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272621001887 Walker A motif; other site 272621001888 ATP binding site [chemical binding]; other site 272621001889 Walker B motif; other site 272621001890 arginine finger; other site 272621001891 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272621001892 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 272621001893 dimerization domain swap beta strand [polypeptide binding]; other site 272621001894 regulatory protein interface [polypeptide binding]; other site 272621001895 active site 272621001896 regulatory phosphorylation site [posttranslational modification]; other site 272621001897 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 272621001898 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 272621001899 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272621001900 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272621001901 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 272621001902 putative catalytic residues [active] 272621001903 thiol/disulfide switch; other site 272621001904 adaptor protein; Provisional; Region: PRK02315 272621001905 Competence protein CoiA-like family; Region: CoiA; cl11541 272621001906 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 272621001907 catalytic residues [active] 272621001908 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 272621001909 putative active site [active] 272621001910 putative metal binding residues [ion binding]; other site 272621001911 signature motif; other site 272621001912 putative triphosphate binding site [ion binding]; other site 272621001913 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 272621001914 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272621001915 synthetase active site [active] 272621001916 NTP binding site [chemical binding]; other site 272621001917 metal binding site [ion binding]; metal-binding site 272621001918 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 272621001919 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272621001920 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272621001921 active site 272621001922 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 272621001923 myosin-cross-reactive antigen; Provisional; Region: PRK13977 272621001924 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 272621001925 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 272621001926 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 272621001927 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 272621001928 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272621001929 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272621001930 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272621001931 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272621001932 motif II; other site 272621001933 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272621001934 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 272621001935 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272621001936 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 272621001937 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 272621001938 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 272621001939 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 272621001940 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272621001941 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 272621001942 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272621001943 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272621001944 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272621001945 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272621001946 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272621001947 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 272621001948 classical (c) SDRs; Region: SDR_c; cd05233 272621001949 NAD(P) binding site [chemical binding]; other site 272621001950 active site 272621001951 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 272621001952 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272621001953 non-specific DNA binding site [nucleotide binding]; other site 272621001954 salt bridge; other site 272621001955 sequence-specific DNA binding site [nucleotide binding]; other site 272621001956 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 272621001957 recombinase A; Provisional; Region: recA; PRK09354 272621001958 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 272621001959 hexamer interface [polypeptide binding]; other site 272621001960 Walker A motif; other site 272621001961 ATP binding site [chemical binding]; other site 272621001962 Walker B motif; other site 272621001963 phosphodiesterase; Provisional; Region: PRK12704 272621001964 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; cl19842 272621001965 KH domain; Region: KH_1; pfam00013 272621001966 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272621001967 Zn2+ binding site [ion binding]; other site 272621001968 Mg2+ binding site [ion binding]; other site 272621001969 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 272621001970 Mg++ binding site [ion binding]; other site 272621001971 putative catalytic motif [active] 272621001972 substrate binding site [chemical binding]; other site 272621001973 Uncharacterized conserved protein [Function unknown]; Region: COG1739 272621001974 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 272621001975 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 272621001976 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 272621001977 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272621001978 ATP binding site [chemical binding]; other site 272621001979 putative Mg++ binding site [ion binding]; other site 272621001980 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272621001981 nucleotide binding region [chemical binding]; other site 272621001982 ATP-binding site [chemical binding]; other site 272621001983 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 272621001984 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272621001985 active site 272621001986 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 272621001987 30S subunit binding site; other site 272621001988 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 272621001989 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 272621001990 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272621001991 nucleotide binding region [chemical binding]; other site 272621001992 ATP-binding site [chemical binding]; other site 272621001993 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 272621001994 peptide chain release factor 2; Provisional; Region: PRK05589 272621001995 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272621001996 RF-1 domain; Region: RF-1; pfam00472 272621001997 HPr kinase/phosphorylase; Provisional; Region: PRK05428 272621001998 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 272621001999 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 272621002000 Hpr binding site; other site 272621002001 active site 272621002002 homohexamer subunit interaction site [polypeptide binding]; other site 272621002003 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 272621002004 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 272621002005 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 272621002006 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 272621002007 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 272621002008 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 272621002009 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272621002010 glycogen branching enzyme; Provisional; Region: PRK12313 272621002011 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 272621002012 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 272621002013 active site 272621002014 catalytic site [active] 272621002015 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 272621002016 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 272621002017 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 272621002018 ligand binding site; other site 272621002019 oligomer interface; other site 272621002020 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 272621002021 dimer interface [polypeptide binding]; other site 272621002022 N-terminal domain interface [polypeptide binding]; other site 272621002023 sulfate 1 binding site; other site 272621002024 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 272621002025 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272621002026 active site 272621002027 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 272621002028 dimer interface [polypeptide binding]; other site 272621002029 N-terminal domain interface [polypeptide binding]; other site 272621002030 sulfate 1 binding site; other site 272621002031 glycogen synthase; Provisional; Region: glgA; PRK00654 272621002032 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 272621002033 ADP-binding pocket [chemical binding]; other site 272621002034 homodimer interface [polypeptide binding]; other site 272621002035 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 272621002036 homodimer interface [polypeptide binding]; other site 272621002037 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 272621002038 active site pocket [active] 272621002039 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 272621002040 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 272621002041 active site 272621002042 homodimer interface [polypeptide binding]; other site 272621002043 catalytic site [active] 272621002044 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 272621002045 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 272621002046 active site 272621002047 substrate binding site [chemical binding]; other site 272621002048 metal binding site [ion binding]; metal-binding site 272621002049 excinuclease ABC subunit B; Provisional; Region: PRK05298 272621002050 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 272621002051 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272621002052 ATP-binding site [chemical binding]; other site 272621002053 ATP binding site [chemical binding]; other site 272621002054 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272621002055 nucleotide binding region [chemical binding]; other site 272621002056 ATP-binding site [chemical binding]; other site 272621002057 Ultra-violet resistance protein B; Region: UvrB; pfam12344 272621002058 UvrB/uvrC motif; Region: UVR; pfam02151 272621002059 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 272621002060 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272621002061 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272621002062 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 272621002063 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 272621002064 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 272621002065 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 272621002066 phosphate binding site [ion binding]; other site 272621002067 putative substrate binding pocket [chemical binding]; other site 272621002068 dimer interface [polypeptide binding]; other site 272621002069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 272621002070 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 272621002071 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 272621002072 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 272621002073 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 272621002074 oligomer interface [polypeptide binding]; other site 272621002075 active site residues [active] 272621002076 SH3-like domain; Region: SH3_8; pfam13457 272621002077 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272621002078 Amino acid permease; Region: AA_permease_2; pfam13520 272621002079 Predicted transcriptional regulator [Transcription]; Region: COG3388 272621002080 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 272621002081 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 272621002082 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 272621002083 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 272621002084 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272621002085 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 272621002086 substrate binding site [chemical binding]; other site 272621002087 hinge regions; other site 272621002088 ADP binding site [chemical binding]; other site 272621002089 catalytic site [active] 272621002090 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 272621002091 substrate binding site [chemical binding]; other site 272621002092 dimer interface [polypeptide binding]; other site 272621002093 catalytic triad [active] 272621002094 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272621002095 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272621002096 active site 272621002097 motif I; other site 272621002098 motif II; other site 272621002099 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272621002100 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 272621002101 ligand binding site [chemical binding]; other site 272621002102 active site 272621002103 UGI interface [polypeptide binding]; other site 272621002104 catalytic site [active] 272621002105 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 272621002106 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 272621002107 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 272621002108 active site 272621002109 catalytic site [active] 272621002110 substrate binding site [chemical binding]; other site 272621002111 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 272621002112 FAD binding domain; Region: FAD_binding_4; pfam01565 272621002113 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 272621002114 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 272621002115 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 272621002116 Walker A/P-loop; other site 272621002117 ATP binding site [chemical binding]; other site 272621002118 Q-loop/lid; other site 272621002119 ABC transporter signature motif; other site 272621002120 Walker B; other site 272621002121 D-loop; other site 272621002122 H-loop/switch region; other site 272621002123 TOBE domain; Region: TOBE_2; pfam08402 272621002124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272621002125 dimer interface [polypeptide binding]; other site 272621002126 conserved gate region; other site 272621002127 putative PBP binding loops; other site 272621002128 ABC-ATPase subunit interface; other site 272621002129 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272621002130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272621002131 dimer interface [polypeptide binding]; other site 272621002132 conserved gate region; other site 272621002133 putative PBP binding loops; other site 272621002134 ABC-ATPase subunit interface; other site 272621002135 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 272621002136 Uncharacterized conserved protein [Function unknown]; Region: COG1624 272621002137 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 272621002138 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 272621002139 YbbR-like protein; Region: YbbR; pfam07949 272621002140 YbbR-like protein; Region: YbbR; pfam07949 272621002141 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 272621002142 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 272621002143 active site 272621002144 substrate binding site [chemical binding]; other site 272621002145 metal binding site [ion binding]; metal-binding site 272621002146 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272621002147 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272621002148 active site 272621002149 motif I; other site 272621002150 motif II; other site 272621002151 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272621002152 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272621002153 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272621002154 active site 272621002155 motif I; other site 272621002156 motif II; other site 272621002157 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272621002158 clostripain; Region: clostrip; TIGR02806 272621002159 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272621002160 active site 272621002161 glycerate kinase; Region: TIGR00045 272621002162 transcriptional antiterminator BglG; Provisional; Region: PRK09772 272621002163 CAT RNA binding domain; Region: CAT_RBD; smart01061 272621002164 PRD domain; Region: PRD; pfam00874 272621002165 PRD domain; Region: PRD; pfam00874 272621002166 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 272621002167 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272621002168 active site turn [active] 272621002169 phosphorylation site [posttranslational modification] 272621002170 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272621002171 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272621002172 HPr interaction site; other site 272621002173 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272621002174 active site 272621002175 phosphorylation site [posttranslational modification] 272621002176 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 272621002177 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 272621002178 CcmE; Region: CcmE; cl00994 272621002179 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 272621002180 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272621002181 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272621002182 Amino acid permease; Region: AA_permease_2; pfam13520 272621002183 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 272621002184 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 272621002185 Predicted integral membrane protein [Function unknown]; Region: COG5652 272621002186 hypothetical protein; Validated; Region: PRK00110 272621002187 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272621002188 Walker A motif; other site 272621002189 ATP binding site [chemical binding]; other site 272621002190 Walker B motif; other site 272621002191 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272621002192 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272621002193 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 272621002194 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 272621002195 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 272621002196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272621002197 S-adenosylmethionine binding site [chemical binding]; other site 272621002198 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 272621002199 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 272621002200 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272621002201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272621002202 homodimer interface [polypeptide binding]; other site 272621002203 catalytic residue [active] 272621002204 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 272621002205 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 272621002206 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 272621002207 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272621002208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272621002209 active site 272621002210 phosphorylation site [posttranslational modification] 272621002211 intermolecular recognition site; other site 272621002212 dimerization interface [polypeptide binding]; other site 272621002213 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272621002214 DNA binding site [nucleotide binding] 272621002215 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 272621002216 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272621002217 dimerization interface [polypeptide binding]; other site 272621002218 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272621002219 dimer interface [polypeptide binding]; other site 272621002220 phosphorylation site [posttranslational modification] 272621002221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272621002222 ATP binding site [chemical binding]; other site 272621002223 Mg2+ binding site [ion binding]; other site 272621002224 G-X-G motif; other site 272621002225 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 272621002226 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 272621002227 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 272621002228 Sulfatase; Region: Sulfatase; pfam00884 272621002229 VanZ like family; Region: VanZ; pfam04892 272621002230 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 272621002231 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 272621002232 active site 272621002233 dimer interface [polypeptide binding]; other site 272621002234 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 272621002235 dimer interface [polypeptide binding]; other site 272621002236 active site 272621002237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272621002238 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272621002239 putative substrate translocation pore; other site 272621002240 Beta-lactamase; Region: Beta-lactamase; pfam00144 272621002241 D5 N terminal like; Region: D5_N; smart00885 272621002242 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 272621002243 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 272621002244 Helix-turn-helix domain; Region: HTH_17; cl17695 272621002245 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272621002246 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272621002247 non-specific DNA binding site [nucleotide binding]; other site 272621002248 salt bridge; other site 272621002249 sequence-specific DNA binding site [nucleotide binding]; other site 272621002250 complex II; Region: PLN02720 272621002251 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 272621002252 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272621002253 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 272621002254 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 272621002255 Int/Topo IB signature motif; other site 272621002256 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 272621002257 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272621002258 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 272621002259 thymidine kinase; Provisional; Region: PRK04296 272621002260 peptide chain release factor 1; Validated; Region: prfA; PRK00591 272621002261 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272621002262 RF-1 domain; Region: RF-1; pfam00472 272621002263 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 272621002264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272621002265 S-adenosylmethionine binding site [chemical binding]; other site 272621002266 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 272621002267 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 272621002268 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272621002269 active site 272621002270 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 272621002271 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 272621002272 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 272621002273 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 272621002274 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 272621002275 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 272621002276 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272621002277 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 272621002278 beta subunit interaction interface [polypeptide binding]; other site 272621002279 Walker A motif; other site 272621002280 ATP binding site [chemical binding]; other site 272621002281 Walker B motif; other site 272621002282 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272621002283 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 272621002284 core domain interface [polypeptide binding]; other site 272621002285 delta subunit interface [polypeptide binding]; other site 272621002286 epsilon subunit interface [polypeptide binding]; other site 272621002287 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 272621002288 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272621002289 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 272621002290 alpha subunit interaction interface [polypeptide binding]; other site 272621002291 Walker A motif; other site 272621002292 ATP binding site [chemical binding]; other site 272621002293 Walker B motif; other site 272621002294 inhibitor binding site; inhibition site 272621002295 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272621002296 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 272621002297 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 272621002298 gamma subunit interface [polypeptide binding]; other site 272621002299 epsilon subunit interface [polypeptide binding]; other site 272621002300 LBP interface [polypeptide binding]; other site 272621002301 rod shape-determining protein MreB; Provisional; Region: PRK13930 272621002302 MreB and similar proteins; Region: MreB_like; cd10225 272621002303 nucleotide binding site [chemical binding]; other site 272621002304 Mg binding site [ion binding]; other site 272621002305 putative protofilament interaction site [polypeptide binding]; other site 272621002306 RodZ interaction site [polypeptide binding]; other site 272621002307 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 272621002308 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 272621002309 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272621002310 Ligand Binding Site [chemical binding]; other site 272621002311 recombination factor protein RarA; Reviewed; Region: PRK13342 272621002312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272621002313 Walker A motif; other site 272621002314 ATP binding site [chemical binding]; other site 272621002315 Walker B motif; other site 272621002316 arginine finger; other site 272621002317 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 272621002318 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 272621002319 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 272621002320 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 272621002321 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272621002322 RNA binding surface [nucleotide binding]; other site 272621002323 septation ring formation regulator EzrA; Provisional; Region: PRK04778 272621002324 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 272621002325 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272621002326 catalytic residue [active] 272621002327 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 272621002328 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 272621002329 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 272621002330 Ligand Binding Site [chemical binding]; other site 272621002331 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 272621002332 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272621002333 RNA binding surface [nucleotide binding]; other site 272621002334 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 272621002335 active site 272621002336 uracil binding [chemical binding]; other site 272621002337 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 272621002338 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 272621002339 active site 272621002340 HIGH motif; other site 272621002341 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272621002342 KMSKS motif; other site 272621002343 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 272621002344 tRNA binding surface [nucleotide binding]; other site 272621002345 anticodon binding site; other site 272621002346 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 272621002347 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 272621002348 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272621002349 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272621002350 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 272621002351 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272621002352 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272621002353 motif II; other site 272621002354 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 272621002355 MPN+ (JAMM) motif; other site 272621002356 Zinc-binding site [ion binding]; other site 272621002357 rod shape-determining protein MreB; Provisional; Region: PRK13927 272621002358 MreB and similar proteins; Region: MreB_like; cd10225 272621002359 nucleotide binding site [chemical binding]; other site 272621002360 Mg binding site [ion binding]; other site 272621002361 putative protofilament interaction site [polypeptide binding]; other site 272621002362 RodZ interaction site [polypeptide binding]; other site 272621002363 rod shape-determining protein MreC; Provisional; Region: PRK13922 272621002364 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 272621002365 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 272621002366 Cell division protein FtsL; Region: FtsL; cl11433 272621002367 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272621002368 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 272621002369 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272621002370 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 272621002371 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 272621002372 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 272621002373 Mg++ binding site [ion binding]; other site 272621002374 putative catalytic motif [active] 272621002375 putative substrate binding site [chemical binding]; other site 272621002376 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 272621002377 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272621002378 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272621002379 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272621002380 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 272621002381 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 272621002382 active site 272621002383 homodimer interface [polypeptide binding]; other site 272621002384 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 272621002385 Cell division protein FtsQ; Region: FtsQ; pfam03799 272621002386 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 272621002387 Cell division protein FtsA; Region: FtsA; smart00842 272621002388 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272621002389 nucleotide binding site [chemical binding]; other site 272621002390 Cell division protein FtsA; Region: FtsA; pfam14450 272621002391 cell division protein FtsZ; Validated; Region: PRK09330 272621002392 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 272621002393 nucleotide binding site [chemical binding]; other site 272621002394 SulA interaction site; other site 272621002395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 272621002396 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 272621002397 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272621002398 RNA binding surface [nucleotide binding]; other site 272621002399 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 272621002400 DivIVA protein; Region: DivIVA; pfam05103 272621002401 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 272621002402 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 272621002403 active site 272621002404 HIGH motif; other site 272621002405 KMSKS motif; other site 272621002406 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 272621002407 tRNA binding surface [nucleotide binding]; other site 272621002408 anticodon binding site; other site 272621002409 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 272621002410 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272621002411 DNA-binding site [nucleotide binding]; DNA binding site 272621002412 RNA-binding motif; other site 272621002413 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 272621002414 dimer interface [polypeptide binding]; other site 272621002415 ADP-ribose binding site [chemical binding]; other site 272621002416 active site 272621002417 nudix motif; other site 272621002418 metal binding site [ion binding]; metal-binding site 272621002419 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 272621002420 Putative amino acid metabolizm; Region: DUF1831; pfam08866 272621002421 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 272621002422 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 272621002423 Ligand Binding Site [chemical binding]; other site 272621002424 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272621002425 catalytic core [active] 272621002426 Tetratricopeptide repeat; Region: TPR_19; pfam14559 272621002427 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272621002428 binding surface 272621002429 TPR motif; other site 272621002430 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 272621002431 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 272621002432 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 272621002433 AAA domain; Region: AAA_30; pfam13604 272621002434 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272621002435 Nuclease-related domain; Region: NERD; pfam08378 272621002436 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 272621002437 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 272621002438 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272621002439 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 272621002440 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 272621002441 hypothetical protein; Provisional; Region: PRK13667 272621002442 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272621002443 active site 272621002444 catalytic residues [active] 272621002445 metal binding site [ion binding]; metal-binding site 272621002446 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 272621002447 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 272621002448 G1 box; other site 272621002449 putative GEF interaction site [polypeptide binding]; other site 272621002450 GTP/Mg2+ binding site [chemical binding]; other site 272621002451 Switch I region; other site 272621002452 G2 box; other site 272621002453 G3 box; other site 272621002454 Switch II region; other site 272621002455 G4 box; other site 272621002456 G5 box; other site 272621002457 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 272621002458 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272621002459 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 272621002460 cell division protein FtsW; Region: ftsW; TIGR02614 272621002461 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 272621002462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272621002463 S-adenosylmethionine binding site [chemical binding]; other site 272621002464 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 272621002465 active site 272621002466 (T/H)XGH motif; other site 272621002467 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 272621002468 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272621002469 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272621002470 SLBB domain; Region: SLBB; pfam10531 272621002471 comEA protein; Region: comE; TIGR01259 272621002472 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 272621002473 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 272621002474 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 272621002475 Competence protein; Region: Competence; pfam03772 272621002476 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 272621002477 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272621002478 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912 272621002479 DNA polymerase III, delta subunit; Region: holA; TIGR01128 272621002480 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 272621002481 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 272621002482 S13e-L30e interaction site [polypeptide binding]; other site 272621002483 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272621002484 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272621002485 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 272621002486 elongation factor Tu; Reviewed; Region: PRK00049 272621002487 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 272621002488 G1 box; other site 272621002489 GEF interaction site [polypeptide binding]; other site 272621002490 GTP/Mg2+ binding site [chemical binding]; other site 272621002491 Switch I region; other site 272621002492 G2 box; other site 272621002493 G3 box; other site 272621002494 Switch II region; other site 272621002495 G4 box; other site 272621002496 G5 box; other site 272621002497 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 272621002498 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 272621002499 Antibiotic Binding Site [chemical binding]; other site 272621002500 trigger factor; Provisional; Region: tig; PRK01490 272621002501 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 272621002502 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272621002503 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 272621002504 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 272621002505 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 272621002506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272621002507 Walker A motif; other site 272621002508 ATP binding site [chemical binding]; other site 272621002509 Walker B motif; other site 272621002510 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272621002511 Predicted GTPase [General function prediction only]; Region: COG0218 272621002512 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 272621002513 G1 box; other site 272621002514 GTP/Mg2+ binding site [chemical binding]; other site 272621002515 Switch I region; other site 272621002516 G2 box; other site 272621002517 G3 box; other site 272621002518 Switch II region; other site 272621002519 G4 box; other site 272621002520 G5 box; other site 272621002521 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 272621002522 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 272621002523 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 272621002524 aspartate kinase; Reviewed; Region: PRK09034 272621002525 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 272621002526 putative catalytic residues [active] 272621002527 putative nucleotide binding site [chemical binding]; other site 272621002528 putative aspartate binding site [chemical binding]; other site 272621002529 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 272621002530 allosteric regulatory residue; other site 272621002531 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 272621002532 diaminopimelate decarboxylase; Region: lysA; TIGR01048 272621002533 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 272621002534 active site 272621002535 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272621002536 substrate binding site [chemical binding]; other site 272621002537 catalytic residues [active] 272621002538 dimer interface [polypeptide binding]; other site 272621002539 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 272621002540 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 272621002541 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 272621002542 trimer interface [polypeptide binding]; other site 272621002543 active site 272621002544 substrate binding site [chemical binding]; other site 272621002545 CoA binding site [chemical binding]; other site 272621002546 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272621002547 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 272621002548 metal binding site [ion binding]; metal-binding site 272621002549 putative dimer interface [polypeptide binding]; other site 272621002550 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 272621002551 dimer interface [polypeptide binding]; other site 272621002552 active site 272621002553 catalytic residue [active] 272621002554 dihydrodipicolinate reductase; Provisional; Region: PRK00048 272621002555 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 272621002556 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 272621002557 aminotransferase A; Validated; Region: PRK07683 272621002558 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272621002559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272621002560 homodimer interface [polypeptide binding]; other site 272621002561 catalytic residue [active] 272621002562 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 272621002563 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 272621002564 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 272621002565 Beta-lactamase; Region: Beta-lactamase; pfam00144 272621002566 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 272621002567 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 272621002568 FMN-binding domain; Region: FMN_bind; pfam04205 272621002569 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 272621002570 active site 272621002571 dimerization interface [polypeptide binding]; other site 272621002572 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 272621002573 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272621002574 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272621002575 non-specific DNA binding site [nucleotide binding]; other site 272621002576 salt bridge; other site 272621002577 sequence-specific DNA binding site [nucleotide binding]; other site 272621002578 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272621002579 Predicted membrane protein [Function unknown]; Region: COG2261 272621002580 CsbD-like; Region: CsbD; pfam05532 272621002581 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 272621002582 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 272621002583 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272621002584 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272621002585 DNA-binding site [nucleotide binding]; DNA binding site 272621002586 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 272621002587 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 272621002588 active site 272621002589 P-loop; other site 272621002590 phosphorylation site [posttranslational modification] 272621002591 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 272621002592 active site 272621002593 methionine cluster; other site 272621002594 phosphorylation site [posttranslational modification] 272621002595 metal binding site [ion binding]; metal-binding site 272621002596 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl19164 272621002597 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 272621002598 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 272621002599 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 272621002600 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272621002601 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272621002602 DNA-binding site [nucleotide binding]; DNA binding site 272621002603 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 272621002604 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272621002605 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272621002606 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 272621002607 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272621002608 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272621002609 nucleotide binding site [chemical binding]; other site 272621002610 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 272621002611 FMN binding site [chemical binding]; other site 272621002612 dimer interface [polypeptide binding]; other site 272621002613 enolase; Provisional; Region: eno; PRK00077 272621002614 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 272621002615 dimer interface [polypeptide binding]; other site 272621002616 metal binding site [ion binding]; metal-binding site 272621002617 substrate binding pocket [chemical binding]; other site 272621002618 EDD domain protein, DegV family; Region: DegV; TIGR00762 272621002619 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 272621002620 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272621002621 active site 272621002622 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 272621002623 active site 272621002624 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 272621002625 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272621002626 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 272621002627 Int/Topo IB signature motif; other site 272621002628 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272621002629 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272621002630 non-specific DNA binding site [nucleotide binding]; other site 272621002631 salt bridge; other site 272621002632 sequence-specific DNA binding site [nucleotide binding]; other site 272621002633 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272621002634 non-specific DNA binding site [nucleotide binding]; other site 272621002635 salt bridge; other site 272621002636 sequence-specific DNA binding site [nucleotide binding]; other site 272621002637 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 272621002638 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 272621002639 dimerization interface [polypeptide binding]; other site 272621002640 active site 272621002641 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 272621002642 folate binding site [chemical binding]; other site 272621002643 NADP+ binding site [chemical binding]; other site 272621002644 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272621002645 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272621002646 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272621002647 motif II; other site 272621002648 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272621002649 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 272621002650 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 272621002651 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 272621002652 Walker A/P-loop; other site 272621002653 ATP binding site [chemical binding]; other site 272621002654 Q-loop/lid; other site 272621002655 ABC transporter signature motif; other site 272621002656 Walker B; other site 272621002657 D-loop; other site 272621002658 H-loop/switch region; other site 272621002659 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 272621002660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272621002661 dimer interface [polypeptide binding]; other site 272621002662 conserved gate region; other site 272621002663 ABC-ATPase subunit interface; other site 272621002664 fumarate hydratase; Reviewed; Region: fumC; PRK00485 272621002665 Class II fumarases; Region: Fumarase_classII; cd01362 272621002666 active site 272621002667 tetramer interface [polypeptide binding]; other site 272621002668 L-aspartate oxidase; Provisional; Region: PRK06175 272621002669 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 272621002670 MucBP domain; Region: MucBP; pfam06458 272621002671 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 272621002672 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 272621002673 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272621002674 NAD binding site [chemical binding]; other site 272621002675 dimer interface [polypeptide binding]; other site 272621002676 substrate binding site [chemical binding]; other site 272621002677 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 272621002678 trimer interface [polypeptide binding]; other site 272621002679 active site 272621002680 G bulge; other site 272621002681 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 272621002682 anion transporter; Region: dass; TIGR00785 272621002683 transmembrane helices; other site 272621002684 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272621002685 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272621002686 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 272621002687 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 272621002688 putative active site [active] 272621002689 (T/H)XGH motif; other site 272621002690 citrate lyase subunit gamma; Provisional; Region: PRK13253 272621002691 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 272621002692 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 272621002693 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 272621002694 Protein of unknown function (DUF441); Region: DUF441; pfam04284 272621002695 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 272621002696 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272621002697 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272621002698 Walker A/P-loop; other site 272621002699 ATP binding site [chemical binding]; other site 272621002700 Q-loop/lid; other site 272621002701 ABC transporter signature motif; other site 272621002702 Walker B; other site 272621002703 D-loop; other site 272621002704 H-loop/switch region; other site 272621002705 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 272621002706 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272621002707 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272621002708 Walker A/P-loop; other site 272621002709 ATP binding site [chemical binding]; other site 272621002710 Q-loop/lid; other site 272621002711 ABC transporter signature motif; other site 272621002712 Walker B; other site 272621002713 D-loop; other site 272621002714 H-loop/switch region; other site 272621002715 hypothetical protein; Provisional; Region: PRK13661 272621002716 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 272621002717 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 272621002718 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 272621002719 Uncharacterized conserved protein [Function unknown]; Region: COG2966 272621002720 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 272621002721 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 272621002722 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 272621002723 putative deacylase active site [active] 272621002724 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 272621002725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272621002726 S-adenosylmethionine binding site [chemical binding]; other site 272621002727 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 272621002728 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272621002729 Zn2+ binding site [ion binding]; other site 272621002730 Mg2+ binding site [ion binding]; other site 272621002731 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272621002732 synthetase active site [active] 272621002733 NTP binding site [chemical binding]; other site 272621002734 metal binding site [ion binding]; metal-binding site 272621002735 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 272621002736 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 272621002737 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 272621002738 putative active site [active] 272621002739 dimerization interface [polypeptide binding]; other site 272621002740 putative tRNAtyr binding site [nucleotide binding]; other site 272621002741 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 272621002742 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 272621002743 dimer interface [polypeptide binding]; other site 272621002744 motif 1; other site 272621002745 active site 272621002746 motif 2; other site 272621002747 motif 3; other site 272621002748 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 272621002749 anticodon binding site; other site 272621002750 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 272621002751 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 272621002752 dimer interface [polypeptide binding]; other site 272621002753 anticodon binding site; other site 272621002754 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 272621002755 homodimer interface [polypeptide binding]; other site 272621002756 motif 1; other site 272621002757 active site 272621002758 motif 2; other site 272621002759 GAD domain; Region: GAD; pfam02938 272621002760 motif 3; other site 272621002761 aspartate aminotransferase; Provisional; Region: PRK05764 272621002762 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272621002763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272621002764 homodimer interface [polypeptide binding]; other site 272621002765 catalytic residue [active] 272621002766 Flavoprotein; Region: Flavoprotein; cl19190 272621002767 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 272621002768 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 272621002769 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272621002770 active site 272621002771 catalytic tetrad [active] 272621002772 sugar phosphate phosphatase; Provisional; Region: PRK10513 272621002773 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272621002774 active site 272621002775 motif I; other site 272621002776 motif II; other site 272621002777 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272621002778 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 272621002779 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 272621002780 putative ligand binding site [chemical binding]; other site 272621002781 putative NAD binding site [chemical binding]; other site 272621002782 catalytic site [active] 272621002783 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 272621002784 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 272621002785 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272621002786 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 272621002787 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 272621002788 GIY-YIG motif/motif A; other site 272621002789 active site 272621002790 catalytic site [active] 272621002791 putative DNA binding site [nucleotide binding]; other site 272621002792 metal binding site [ion binding]; metal-binding site 272621002793 UvrB/uvrC motif; Region: UVR; pfam02151 272621002794 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 272621002795 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 272621002796 DNA binding site [nucleotide binding] 272621002797 GTPase CgtA; Reviewed; Region: obgE; PRK12297 272621002798 GTP1/OBG; Region: GTP1_OBG; pfam01018 272621002799 Obg GTPase; Region: Obg; cd01898 272621002800 G1 box; other site 272621002801 GTP/Mg2+ binding site [chemical binding]; other site 272621002802 Switch I region; other site 272621002803 G2 box; other site 272621002804 G3 box; other site 272621002805 Switch II region; other site 272621002806 G4 box; other site 272621002807 G5 box; other site 272621002808 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 272621002809 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272621002810 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 272621002811 catalytic triad [active] 272621002812 catalytic triad [active] 272621002813 oxyanion hole [active] 272621002814 ribonuclease Z; Region: RNase_Z; TIGR02651 272621002815 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 272621002816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272621002817 NAD(P) binding site [chemical binding]; other site 272621002818 active site 272621002819 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 272621002820 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 272621002821 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 272621002822 active site 272621002823 metal binding site [ion binding]; metal-binding site 272621002824 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272621002825 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 272621002826 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 272621002827 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 272621002828 active site 272621002829 PHP Thumb interface [polypeptide binding]; other site 272621002830 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 272621002831 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 272621002832 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 272621002833 generic binding surface I; other site 272621002834 generic binding surface II; other site 272621002835 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 272621002836 active site 272621002837 ADP/pyrophosphate binding site [chemical binding]; other site 272621002838 dimerization interface [polypeptide binding]; other site 272621002839 allosteric effector site; other site 272621002840 fructose-1,6-bisphosphate binding site; other site 272621002841 pyruvate kinase; Provisional; Region: PRK06354 272621002842 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 272621002843 domain interfaces; other site 272621002844 active site 272621002845 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 272621002846 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 272621002847 S1 domain; Region: S1_2; pfam13509 272621002848 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272621002849 dimerization interface [polypeptide binding]; other site 272621002850 putative DNA binding site [nucleotide binding]; other site 272621002851 putative Zn2+ binding site [ion binding]; other site 272621002852 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272621002853 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 272621002854 active site 272621002855 DNA binding site [nucleotide binding] 272621002856 Int/Topo IB signature motif; other site 272621002857 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 272621002858 ScpA/B protein; Region: ScpA_ScpB; cl00598 272621002859 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 272621002860 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 272621002861 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272621002862 RNA binding surface [nucleotide binding]; other site 272621002863 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 272621002864 active site 272621002865 Predicted membrane protein [Function unknown]; Region: COG3601 272621002866 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272621002867 cytidylate kinase; Provisional; Region: cmk; PRK00023 272621002868 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 272621002869 CMP-binding site; other site 272621002870 The sites determining sugar specificity; other site 272621002871 AAA domain; Region: AAA_17; cl19128 272621002872 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 272621002873 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272621002874 RNA binding site [nucleotide binding]; other site 272621002875 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 272621002876 RNA binding site [nucleotide binding]; other site 272621002877 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 272621002878 RNA binding site [nucleotide binding]; other site 272621002879 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272621002880 RNA binding site [nucleotide binding]; other site 272621002881 GTP-binding protein Der; Reviewed; Region: PRK00093 272621002882 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 272621002883 G1 box; other site 272621002884 GTP/Mg2+ binding site [chemical binding]; other site 272621002885 Switch I region; other site 272621002886 G2 box; other site 272621002887 Switch II region; other site 272621002888 G3 box; other site 272621002889 G4 box; other site 272621002890 G5 box; other site 272621002891 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 272621002892 G1 box; other site 272621002893 GTP/Mg2+ binding site [chemical binding]; other site 272621002894 Switch I region; other site 272621002895 G2 box; other site 272621002896 G3 box; other site 272621002897 Switch II region; other site 272621002898 G4 box; other site 272621002899 G5 box; other site 272621002900 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 272621002901 histone-like DNA-binding protein HU; Region: HU; cd13831 272621002902 dimer interface [polypeptide binding]; other site 272621002903 DNA binding site [nucleotide binding] 272621002904 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272621002905 TPR motif; other site 272621002906 binding surface 272621002907 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272621002908 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272621002909 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272621002910 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 272621002911 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 272621002912 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 272621002913 active site 272621002914 NTP binding site [chemical binding]; other site 272621002915 metal binding triad [ion binding]; metal-binding site 272621002916 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 272621002917 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 272621002918 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 272621002919 EDD domain protein, DegV family; Region: DegV; TIGR00762 272621002920 hypothetical protein; Provisional; Region: PRK13672 272621002921 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 272621002922 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 272621002923 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 272621002924 GTP/Mg2+ binding site [chemical binding]; other site 272621002925 G4 box; other site 272621002926 G5 box; other site 272621002927 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 272621002928 G1 box; other site 272621002929 G1 box; other site 272621002930 GTP/Mg2+ binding site [chemical binding]; other site 272621002931 Switch I region; other site 272621002932 G2 box; other site 272621002933 G2 box; other site 272621002934 G3 box; other site 272621002935 G3 box; other site 272621002936 Switch II region; other site 272621002937 Switch II region; other site 272621002938 G4 box; other site 272621002939 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 272621002940 RNA/DNA hybrid binding site [nucleotide binding]; other site 272621002941 active site 272621002942 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 272621002943 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 272621002944 DNA topoisomerase I; Validated; Region: PRK05582 272621002945 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 272621002946 active site 272621002947 interdomain interaction site; other site 272621002948 putative metal-binding site [ion binding]; other site 272621002949 nucleotide binding site [chemical binding]; other site 272621002950 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 272621002951 domain I; other site 272621002952 DNA binding groove [nucleotide binding] 272621002953 phosphate binding site [ion binding]; other site 272621002954 domain II; other site 272621002955 domain III; other site 272621002956 nucleotide binding site [chemical binding]; other site 272621002957 catalytic site [active] 272621002958 domain IV; other site 272621002959 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272621002960 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272621002961 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 272621002962 Glucose inhibited division protein A; Region: GIDA; pfam01134 272621002963 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 272621002964 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272621002965 active site 272621002966 DNA binding site [nucleotide binding] 272621002967 Int/Topo IB signature motif; other site 272621002968 ATP-dependent protease subunit HslV; Provisional; Region: PRK05456 272621002969 active site 272621002970 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 272621002971 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272621002972 Walker A motif; other site 272621002973 ATP binding site [chemical binding]; other site 272621002974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272621002975 Walker B motif; other site 272621002976 arginine finger; other site 272621002977 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272621002978 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 272621002979 active site 272621002980 catalytic residues [active] 272621002981 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272621002982 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272621002983 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272621002984 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 272621002985 camphor resistance protein CrcB; Provisional; Region: PRK14220 272621002986 dipeptidase PepV; Reviewed; Region: PRK07318 272621002987 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 272621002988 active site 272621002989 metal binding site [ion binding]; metal-binding site 272621002990 Amino acid permease; Region: AA_permease_2; pfam13520 272621002991 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 272621002992 putative ornithine decarboxylase; Region: lacto_ODC_hypo; TIGR04318 272621002993 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 272621002994 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272621002995 catalytic residue [active] 272621002996 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 272621002997 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 272621002998 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272621002999 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 272621003000 TrkA-N domain; Region: TrkA_N; pfam02254 272621003001 TrkA-C domain; Region: TrkA_C; pfam02080 272621003002 Cation transport protein; Region: TrkH; cl17365 272621003003 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 272621003004 Cation transport protein; Region: TrkH; cl17365 272621003005 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 272621003006 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272621003007 ATP binding site [chemical binding]; other site 272621003008 putative Mg++ binding site [ion binding]; other site 272621003009 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272621003010 nucleotide binding region [chemical binding]; other site 272621003011 ATP-binding site [chemical binding]; other site 272621003012 RQC domain; Region: RQC; pfam09382 272621003013 HRDC domain; Region: HRDC; pfam00570 272621003014 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272621003015 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 272621003016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272621003017 Walker A/P-loop; other site 272621003018 ATP binding site [chemical binding]; other site 272621003019 Q-loop/lid; other site 272621003020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272621003021 ABC transporter signature motif; other site 272621003022 Walker B; other site 272621003023 D-loop; other site 272621003024 H-loop/switch region; other site 272621003025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272621003026 Walker A/P-loop; other site 272621003027 ATP binding site [chemical binding]; other site 272621003028 Q-loop/lid; other site 272621003029 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 272621003030 ABC transporter signature motif; other site 272621003031 Walker B; other site 272621003032 D-loop; other site 272621003033 H-loop/switch region; other site 272621003034 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 272621003035 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272621003036 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 272621003037 active site 272621003038 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272621003039 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 272621003040 Coenzyme A binding pocket [chemical binding]; other site 272621003041 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 272621003042 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 272621003043 pyridoxal binding site [chemical binding]; other site 272621003044 dimer interface [polypeptide binding]; other site 272621003045 ATP binding site [chemical binding]; other site 272621003046 Protein of unknown function (DUF3816); Region: DUF3816; cl17272 272621003047 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 272621003048 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272621003049 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272621003050 HPr interaction site; other site 272621003051 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272621003052 active site 272621003053 phosphorylation site [posttranslational modification] 272621003054 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 272621003055 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272621003056 active site turn [active] 272621003057 phosphorylation site [posttranslational modification] 272621003058 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272621003059 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272621003060 DNA-binding site [nucleotide binding]; DNA binding site 272621003061 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 272621003062 UTRA domain; Region: UTRA; pfam07702 272621003063 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 272621003064 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 272621003065 Ca binding site [ion binding]; other site 272621003066 active site 272621003067 catalytic site [active] 272621003068 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272621003069 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272621003070 MucBP domain; Region: MucBP; pfam06458 272621003071 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 272621003072 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 272621003073 MucBP domain; Region: MucBP; pfam06458 272621003074 MucBP domain; Region: MucBP; pfam06458 272621003075 MucBP domain; Region: MucBP; pfam06458 272621003076 MucBP domain; Region: MucBP; pfam06458 272621003077 Immunogenic region of nsp2 protein of arterivirus polyprotein; Region: NSP2-B_epitope; pfam14757 272621003078 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 272621003079 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 272621003080 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 272621003081 MucBP domain; Region: MucBP; pfam06458 272621003082 MucBP domain; Region: MucBP; pfam06458 272621003083 MucBP domain; Region: MucBP; pfam06458 272621003084 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 272621003085 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272621003086 DNA binding residues [nucleotide binding] 272621003087 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 272621003088 active site 272621003089 Mn binding site [ion binding]; other site 272621003090 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272621003091 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 272621003092 NAD(P) binding site [chemical binding]; other site 272621003093 putative active site [active] 272621003094 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272621003095 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272621003096 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272621003097 active site 272621003098 catalytic tetrad [active] 272621003099 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272621003100 active site 272621003101 catalytic tetrad [active] 272621003102 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272621003103 active site 272621003104 catalytic tetrad [active] 272621003105 Bacterial surface layer protein; Region: SLAP; pfam03217 272621003106 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272621003107 Coenzyme A binding pocket [chemical binding]; other site 272621003108 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272621003109 NAD(P) binding site [chemical binding]; other site 272621003110 Rrf2 family protein; Region: rrf2_super; TIGR00738 272621003111 Transcriptional regulator; Region: Rrf2; pfam02082 272621003112 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 272621003113 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272621003114 active site 272621003115 catalytic tetrad [active] 272621003116 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272621003117 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272621003118 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 272621003119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272621003120 dimer interface [polypeptide binding]; other site 272621003121 conserved gate region; other site 272621003122 putative PBP binding loops; other site 272621003123 ABC-ATPase subunit interface; other site 272621003124 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 272621003125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272621003126 dimer interface [polypeptide binding]; other site 272621003127 conserved gate region; other site 272621003128 putative PBP binding loops; other site 272621003129 ABC-ATPase subunit interface; other site 272621003130 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272621003131 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272621003132 Walker A/P-loop; other site 272621003133 ATP binding site [chemical binding]; other site 272621003134 Q-loop/lid; other site 272621003135 ABC transporter signature motif; other site 272621003136 Walker B; other site 272621003137 D-loop; other site 272621003138 H-loop/switch region; other site 272621003139 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 272621003140 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272621003141 substrate binding pocket [chemical binding]; other site 272621003142 membrane-bound complex binding site; other site 272621003143 hinge residues; other site 272621003144 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 272621003145 dimer interface [polypeptide binding]; other site 272621003146 catalytic triad [active] 272621003147 peroxidatic and resolving cysteines [active] 272621003148 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272621003149 catalytic core [active] 272621003150 Amidohydrolase; Region: Amidohydro_2; pfam04909 272621003151 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 272621003152 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 272621003153 catalytic triad [active] 272621003154 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 272621003155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272621003156 putative substrate translocation pore; other site 272621003157 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272621003158 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272621003159 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272621003160 dimerization interface [polypeptide binding]; other site 272621003161 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 272621003162 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 272621003163 nudix motif; other site 272621003164 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 272621003165 nucleotide binding site/active site [active] 272621003166 HIT family signature motif; other site 272621003167 catalytic residue [active] 272621003168 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272621003169 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272621003170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272621003171 putative substrate translocation pore; other site 272621003172 hypothetical protein; Provisional; Region: PRK06762 272621003173 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 272621003174 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272621003175 catalytic core [active] 272621003176 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 272621003177 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 272621003178 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 272621003179 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272621003180 motif II; other site 272621003181 Membrane transport protein; Region: Mem_trans; cl09117 272621003182 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272621003183 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272621003184 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272621003185 dimerization interface [polypeptide binding]; other site 272621003186 malate dehydrogenase; Provisional; Region: PRK13529 272621003187 Malic enzyme, N-terminal domain; Region: malic; pfam00390 272621003188 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 272621003189 NAD(P) binding pocket [chemical binding]; other site 272621003190 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 272621003191 recombination factor protein RarA; Reviewed; Region: PRK13342 272621003192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272621003193 Walker A motif; other site 272621003194 ATP binding site [chemical binding]; other site 272621003195 Walker B motif; other site 272621003196 arginine finger; other site 272621003197 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 272621003198 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 272621003199 active site 272621003200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272621003201 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272621003202 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 272621003203 substrate binding site [chemical binding]; other site 272621003204 THF binding site; other site 272621003205 zinc-binding site [ion binding]; other site 272621003206 S-ribosylhomocysteinase; Provisional; Region: PRK02260 272621003207 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 272621003208 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 272621003209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272621003210 NAD(P) binding site [chemical binding]; other site 272621003211 active site 272621003212 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 272621003213 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 272621003214 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272621003215 dimer interface [polypeptide binding]; other site 272621003216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272621003217 catalytic residue [active] 272621003218 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 272621003219 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 272621003220 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272621003221 substrate-cofactor binding pocket; other site 272621003222 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272621003223 catalytic residue [active] 272621003224 S-ribosylhomocysteinase; Provisional; Region: PRK02260 272621003225 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 272621003226 The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; Region: NR_LBD; cl11397 272621003227 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; cl19470 272621003228 Predicted transcriptional regulator [Transcription]; Region: COG2378 272621003229 HTH domain; Region: HTH_11; pfam08279 272621003230 WYL domain; Region: WYL; pfam13280 272621003231 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 272621003232 glucose-1-dehydrogenase; Provisional; Region: PRK08936 272621003233 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272621003234 NAD(P) binding site [chemical binding]; other site 272621003235 active site 272621003236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272621003237 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272621003238 catalytic tetrad [active] 272621003239 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 272621003240 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 272621003241 Sugar transport protein; Region: Sugar_transport; pfam06800 272621003242 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272621003243 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272621003244 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 272621003245 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 272621003246 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272621003247 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272621003248 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272621003249 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272621003250 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272621003251 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 272621003252 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272621003253 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272621003254 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 272621003255 FAD binding pocket [chemical binding]; other site 272621003256 conserved FAD binding motif [chemical binding]; other site 272621003257 phosphate binding motif [ion binding]; other site 272621003258 beta-alpha-beta structure motif; other site 272621003259 NAD binding pocket [chemical binding]; other site 272621003260 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 272621003261 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272621003262 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 272621003263 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 272621003264 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 272621003265 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 272621003266 helix-hairpin-helix signature motif; other site 272621003267 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 272621003268 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 272621003269 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 272621003270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272621003271 ATP binding site [chemical binding]; other site 272621003272 Mg2+ binding site [ion binding]; other site 272621003273 G-X-G motif; other site 272621003274 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272621003275 anchoring element; other site 272621003276 dimer interface [polypeptide binding]; other site 272621003277 ATP binding site [chemical binding]; other site 272621003278 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 272621003279 active site 272621003280 metal binding site [ion binding]; metal-binding site 272621003281 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272621003282 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 272621003283 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272621003284 CAP-like domain; other site 272621003285 active site 272621003286 primary dimer interface [polypeptide binding]; other site 272621003287 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272621003288 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272621003289 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272621003290 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272621003291 dimerization interface [polypeptide binding]; other site 272621003292 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 272621003293 DHH family; Region: DHH; pfam01368 272621003294 DHHA2 domain; Region: DHHA2; pfam02833 272621003295 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 272621003296 active site 272621003297 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 272621003298 Fic/DOC family; Region: Fic; cl00960 272621003299 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272621003300 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 272621003301 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 272621003302 Walker A/P-loop; other site 272621003303 ATP binding site [chemical binding]; other site 272621003304 Q-loop/lid; other site 272621003305 ABC transporter signature motif; other site 272621003306 Walker B; other site 272621003307 D-loop; other site 272621003308 H-loop/switch region; other site 272621003309 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272621003310 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272621003311 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 272621003312 Walker A/P-loop; other site 272621003313 ATP binding site [chemical binding]; other site 272621003314 Q-loop/lid; other site 272621003315 ABC transporter signature motif; other site 272621003316 Walker B; other site 272621003317 D-loop; other site 272621003318 H-loop/switch region; other site 272621003319 H+ Antiporter protein; Region: 2A0121; TIGR00900 272621003320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272621003321 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272621003322 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272621003323 dimerization interface [polypeptide binding]; other site 272621003324 putative Zn2+ binding site [ion binding]; other site 272621003325 putative DNA binding site [nucleotide binding]; other site 272621003326 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272621003327 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 272621003328 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 272621003329 active site 272621003330 Bacterial surface layer protein; Region: SLAP; pfam03217 272621003331 AAA domain; Region: AAA_17; cl19128 272621003332 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 272621003333 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272621003334 active site 272621003335 DNA binding site [nucleotide binding] 272621003336 Int/Topo IB signature motif; other site 272621003337 EDD domain protein, DegV family; Region: DegV; TIGR00762 272621003338 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272621003339 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272621003340 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 272621003341 Domain of unknown function (DUF814); Region: DUF814; pfam05670 272621003342 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 272621003343 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272621003344 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272621003345 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 272621003346 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272621003347 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272621003348 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 272621003349 IMP binding site; other site 272621003350 dimer interface [polypeptide binding]; other site 272621003351 interdomain contacts; other site 272621003352 partial ornithine binding site; other site 272621003353 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 272621003354 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 272621003355 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 272621003356 conserved cys residue [active] 272621003357 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 272621003358 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272621003359 RNA binding surface [nucleotide binding]; other site 272621003360 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272621003361 active site 272621003362 lipoprotein signal peptidase; Provisional; Region: PRK14797 272621003363 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 272621003364 Potassium binding sites [ion binding]; other site 272621003365 Cesium cation binding sites [ion binding]; other site 272621003366 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 272621003367 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 272621003368 active site 272621003369 metal binding site [ion binding]; metal-binding site 272621003370 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 272621003371 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 272621003372 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272621003373 cell division protein GpsB; Provisional; Region: PRK14127; cl19517 272621003374 hypothetical protein; Provisional; Region: PRK13660 272621003375 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 272621003376 Transglycosylase; Region: Transgly; pfam00912 272621003377 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 272621003378 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272621003379 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 272621003380 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272621003381 minor groove reading motif; other site 272621003382 helix-hairpin-helix signature motif; other site 272621003383 substrate binding pocket [chemical binding]; other site 272621003384 active site 272621003385 Helix-turn-helix domain; Region: HTH_36; pfam13730 272621003386 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 272621003387 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 272621003388 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 272621003389 putative dimer interface [polypeptide binding]; other site 272621003390 putative anticodon binding site; other site 272621003391 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272621003392 motif 1; other site 272621003393 dimer interface [polypeptide binding]; other site 272621003394 active site 272621003395 motif 2; other site 272621003396 motif 3; other site 272621003397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 272621003398 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 272621003399 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272621003400 active site 272621003401 catalytic site [active] 272621003402 substrate binding site [chemical binding]; other site 272621003403 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272621003404 ATP binding site [chemical binding]; other site 272621003405 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 272621003406 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 272621003407 Part of AAA domain; Region: AAA_19; pfam13245 272621003408 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272621003409 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 272621003410 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 272621003411 mevalonate kinase; Region: mevalon_kin; TIGR00549 272621003412 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272621003413 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 272621003414 diphosphomevalonate decarboxylase; Region: PLN02407 272621003415 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 272621003416 C2 domain; Region: C2; cl14603 272621003417 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272621003418 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272621003419 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 272621003420 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 272621003421 homotetramer interface [polypeptide binding]; other site 272621003422 FMN binding site [chemical binding]; other site 272621003423 homodimer contacts [polypeptide binding]; other site 272621003424 putative active site [active] 272621003425 putative substrate binding site [chemical binding]; other site 272621003426 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272621003427 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272621003428 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272621003429 putative active site [active] 272621003430 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 272621003431 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272621003432 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272621003433 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272621003434 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 272621003435 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272621003436 catalytic residue [active] 272621003437 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 272621003438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272621003439 S-adenosylmethionine binding site [chemical binding]; other site 272621003440 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 272621003441 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272621003442 Catalytic site [active] 272621003443 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 272621003444 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272621003445 Walker A/P-loop; other site 272621003446 ATP binding site [chemical binding]; other site 272621003447 Q-loop/lid; other site 272621003448 ABC transporter signature motif; other site 272621003449 Walker B; other site 272621003450 D-loop; other site 272621003451 H-loop/switch region; other site 272621003452 Predicted transcriptional regulators [Transcription]; Region: COG1725 272621003453 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272621003454 DNA-binding site [nucleotide binding]; DNA binding site 272621003455 peptidase T-like protein; Region: PepT-like; TIGR01883 272621003456 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 272621003457 metal binding site [ion binding]; metal-binding site 272621003458 dimer interface [polypeptide binding]; other site 272621003459 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 272621003460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272621003461 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 272621003462 putative active site [active] 272621003463 nucleotide binding site [chemical binding]; other site 272621003464 nudix motif; other site 272621003465 putative metal binding site [ion binding]; other site 272621003466 Peptidase family M23; Region: Peptidase_M23; pfam01551 272621003467 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 272621003468 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272621003469 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272621003470 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272621003471 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272621003472 DNA binding residues [nucleotide binding] 272621003473 DNA primase; Validated; Region: dnaG; PRK05667 272621003474 CHC2 zinc finger; Region: zf-CHC2; pfam01807 272621003475 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 272621003476 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 272621003477 active site 272621003478 metal binding site [ion binding]; metal-binding site 272621003479 interdomain interaction site; other site 272621003480 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 272621003481 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 272621003482 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 272621003483 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272621003484 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 272621003485 motif 1; other site 272621003486 dimer interface [polypeptide binding]; other site 272621003487 active site 272621003488 motif 2; other site 272621003489 motif 3; other site 272621003490 Recombination protein O N terminal; Region: RecO_N; pfam11967 272621003491 DNA repair protein RecO; Region: reco; TIGR00613 272621003492 Recombination protein O C terminal; Region: RecO_C; pfam02565 272621003493 GTPase Era; Reviewed; Region: era; PRK00089 272621003494 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 272621003495 G1 box; other site 272621003496 GTP/Mg2+ binding site [chemical binding]; other site 272621003497 Switch I region; other site 272621003498 G2 box; other site 272621003499 Switch II region; other site 272621003500 G3 box; other site 272621003501 G4 box; other site 272621003502 G5 box; other site 272621003503 metal-binding heat shock protein; Provisional; Region: PRK00016 272621003504 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 272621003505 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272621003506 ATP binding site [chemical binding]; other site 272621003507 putative Mg++ binding site [ion binding]; other site 272621003508 Yqey-like protein; Region: YqeY; pfam09424 272621003509 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 272621003510 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 272621003511 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 272621003512 Peptidase family M23; Region: Peptidase_M23; pfam01551 272621003513 methionine sulfoxide reductase A; Provisional; Region: PRK14054 272621003514 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272621003515 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272621003516 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272621003517 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 272621003518 homoserine kinase; Provisional; Region: PRK01212 272621003519 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272621003520 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272621003521 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 272621003522 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 272621003523 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 272621003524 threonine synthase; Validated; Region: PRK09225 272621003525 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 272621003526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272621003527 catalytic residue [active] 272621003528 aspartate kinase; Reviewed; Region: PRK09034 272621003529 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 272621003530 putative catalytic residues [active] 272621003531 putative nucleotide binding site [chemical binding]; other site 272621003532 putative aspartate binding site [chemical binding]; other site 272621003533 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 272621003534 allosteric regulatory residue; other site 272621003535 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 272621003536 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272621003537 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272621003538 peptide binding site [polypeptide binding]; other site 272621003539 maltose O-acetyltransferase; Provisional; Region: PRK10092 272621003540 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 272621003541 active site 272621003542 substrate binding site [chemical binding]; other site 272621003543 trimer interface [polypeptide binding]; other site 272621003544 CoA binding site [chemical binding]; other site 272621003545 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 272621003546 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 272621003547 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 272621003548 TrkA-N domain; Region: TrkA_N; pfam02254 272621003549 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272621003550 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272621003551 SH3-like domain; Region: SH3_8; pfam13457 272621003552 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 272621003553 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 272621003554 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 272621003555 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272621003556 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272621003557 dimerization interface [polypeptide binding]; other site 272621003558 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 272621003559 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272621003560 Coenzyme A binding pocket [chemical binding]; other site 272621003561 Sterol carrier protein domain; Region: SCP2_2; pfam13530 272621003562 holo-ACP synthase CitX; Region: citrate_citX; TIGR03124 272621003563 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272621003564 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272621003565 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272621003566 dimerization interface [polypeptide binding]; other site 272621003567 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 272621003568 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 272621003569 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272621003570 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 272621003571 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272621003572 Bacterial surface layer protein; Region: SLAP; pfam03217 272621003573 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 272621003574 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 272621003575 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 272621003576 putative active site [active] 272621003577 catalytic site [active] 272621003578 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 272621003579 putative active site [active] 272621003580 catalytic site [active] 272621003581 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 272621003582 proposed active site lysine [active] 272621003583 conserved cys residue [active] 272621003584 cysteine synthase; Region: PLN02565 272621003585 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272621003586 dimer interface [polypeptide binding]; other site 272621003587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272621003588 catalytic residue [active] 272621003589 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 272621003590 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 272621003591 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272621003592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272621003593 Coenzyme A binding pocket [chemical binding]; other site 272621003594 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272621003595 active site 272621003596 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 272621003597 DHH family; Region: DHH; pfam01368 272621003598 Chorismate mutase type II; Region: CM_2; cl00693 272621003599 DHHA1 domain; Region: DHHA1; pfam02272 272621003600 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 272621003601 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 272621003602 active site 272621003603 catalytic site [active] 272621003604 GTP-binding protein LepA; Provisional; Region: PRK05433 272621003605 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 272621003606 G1 box; other site 272621003607 putative GEF interaction site [polypeptide binding]; other site 272621003608 GTP/Mg2+ binding site [chemical binding]; other site 272621003609 Switch I region; other site 272621003610 G2 box; other site 272621003611 G3 box; other site 272621003612 Switch II region; other site 272621003613 G4 box; other site 272621003614 G5 box; other site 272621003615 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 272621003616 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272621003617 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 272621003618 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 272621003619 chaperone protein DnaJ; Provisional; Region: PRK14276 272621003620 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272621003621 HSP70 interaction site [polypeptide binding]; other site 272621003622 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272621003623 substrate binding site [polypeptide binding]; other site 272621003624 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 272621003625 Zn binding sites [ion binding]; other site 272621003626 dimer interface [polypeptide binding]; other site 272621003627 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 272621003628 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 272621003629 nucleotide binding site [chemical binding]; other site 272621003630 NEF interaction site [polypeptide binding]; other site 272621003631 SBD interface [polypeptide binding]; other site 272621003632 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 272621003633 dimer interface [polypeptide binding]; other site 272621003634 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 272621003635 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 272621003636 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 272621003637 HrcA protein C terminal domain; Region: HrcA; pfam01628 272621003638 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272621003639 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272621003640 ABC transporter; Region: ABC_tran_2; pfam12848 272621003641 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272621003642 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 272621003643 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 272621003644 active site 272621003645 Riboflavin kinase; Region: Flavokinase; smart00904 272621003646 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 272621003647 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 272621003648 RNA binding site [nucleotide binding]; other site 272621003649 active site 272621003650 ribosome-binding factor A; Provisional; Region: PRK13818 272621003651 translation initiation factor IF-2; Validated; Region: infB; PRK05306 272621003652 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272621003653 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272621003654 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 272621003655 G1 box; other site 272621003656 putative GEF interaction site [polypeptide binding]; other site 272621003657 GTP/Mg2+ binding site [chemical binding]; other site 272621003658 Switch I region; other site 272621003659 G2 box; other site 272621003660 G3 box; other site 272621003661 Switch II region; other site 272621003662 G4 box; other site 272621003663 G5 box; other site 272621003664 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 272621003665 Translation-initiation factor 2; Region: IF-2; pfam11987 272621003666 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 272621003667 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 272621003668 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 272621003669 putative RNA binding cleft [nucleotide binding]; other site 272621003670 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 272621003671 NusA N-terminal domain; Region: NusA_N; pfam08529 272621003672 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 272621003673 RNA binding site [nucleotide binding]; other site 272621003674 homodimer interface [polypeptide binding]; other site 272621003675 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272621003676 G-X-X-G motif; other site 272621003677 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272621003678 G-X-X-G motif; other site 272621003679 Sm and related proteins; Region: Sm_like; cl00259 272621003680 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 272621003681 putative oligomer interface [polypeptide binding]; other site 272621003682 putative RNA binding site [nucleotide binding]; other site 272621003683 DNA polymerase III PolC; Validated; Region: polC; PRK00448 272621003684 DNA polymerase III polC-type N-terminus I; Region: DNA_pol3_a_NI; pfam14480 272621003685 DNA polymerase III polC-type N-terminus II; Region: DNA_pol3_a_NII; pfam11490 272621003686 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 272621003687 generic binding surface II; other site 272621003688 generic binding surface I; other site 272621003689 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 272621003690 active site 272621003691 putative PHP Thumb interface [polypeptide binding]; other site 272621003692 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272621003693 active site 272621003694 catalytic site [active] 272621003695 substrate binding site [chemical binding]; other site 272621003696 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 272621003697 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 272621003698 prolyl-tRNA synthetase; Provisional; Region: PRK09194 272621003699 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 272621003700 dimer interface [polypeptide binding]; other site 272621003701 motif 1; other site 272621003702 active site 272621003703 motif 2; other site 272621003704 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 272621003705 putative deacylase active site [active] 272621003706 motif 3; other site 272621003707 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 272621003708 anticodon binding site; other site 272621003709 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 272621003710 RIP metalloprotease RseP; Region: TIGR00054 272621003711 active site 272621003712 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 272621003713 protein binding site [polypeptide binding]; other site 272621003714 putative substrate binding region [chemical binding]; other site 272621003715 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 272621003716 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 272621003717 active site 272621003718 dimer interface [polypeptide binding]; other site 272621003719 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 272621003720 hinge region; other site 272621003721 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 272621003722 putative nucleotide binding site [chemical binding]; other site 272621003723 uridine monophosphate binding site [chemical binding]; other site 272621003724 homohexameric interface [polypeptide binding]; other site 272621003725 elongation factor Ts; Provisional; Region: tsf; PRK09377 272621003726 UBA/TS-N domain; Region: UBA; pfam00627 272621003727 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 272621003728 rRNA interaction site [nucleotide binding]; other site 272621003729 S8 interaction site; other site 272621003730 putative laminin-1 binding site; other site 272621003731 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 272621003732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272621003733 S-adenosylmethionine binding site [chemical binding]; other site 272621003734 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 272621003735 GIY-YIG motif/motif A; other site 272621003736 putative active site [active] 272621003737 putative metal binding site [ion binding]; other site 272621003738 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272621003739 putative acyl-acceptor binding pocket; other site 272621003740 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 272621003741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272621003742 S-adenosylmethionine binding site [chemical binding]; other site 272621003743 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 272621003744 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 272621003745 active site 272621003746 Zn binding site [ion binding]; other site 272621003747 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272621003748 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272621003749 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 272621003750 Walker A/P-loop; other site 272621003751 ATP binding site [chemical binding]; other site 272621003752 Q-loop/lid; other site 272621003753 ABC transporter signature motif; other site 272621003754 Walker B; other site 272621003755 D-loop; other site 272621003756 H-loop/switch region; other site 272621003757 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272621003758 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 272621003759 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272621003760 Walker A/P-loop; other site 272621003761 ATP binding site [chemical binding]; other site 272621003762 Q-loop/lid; other site 272621003763 ABC transporter signature motif; other site 272621003764 Walker B; other site 272621003765 D-loop; other site 272621003766 H-loop/switch region; other site 272621003767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 272621003768 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 272621003769 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272621003770 putative DNA binding site [nucleotide binding]; other site 272621003771 LexA repressor; Validated; Region: PRK00215 272621003772 putative Zn2+ binding site [ion binding]; other site 272621003773 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272621003774 Catalytic site [active] 272621003775 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 272621003776 active site 272621003777 catalytic triad [active] 272621003778 oxyanion hole [active] 272621003779 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 272621003780 active site 272621003781 Fe-S cluster binding site [ion binding]; other site 272621003782 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 272621003783 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 272621003784 Ligand binding site; other site 272621003785 Putative Catalytic site; other site 272621003786 DXD motif; other site 272621003787 GtrA-like protein; Region: GtrA; pfam04138 272621003788 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 272621003789 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 272621003790 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 272621003791 RimM N-terminal domain; Region: RimM; pfam01782 272621003792 PRC-barrel domain; Region: PRC; pfam05239 272621003793 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 272621003794 signal recognition particle protein; Provisional; Region: PRK10867 272621003795 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 272621003796 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272621003797 P loop; other site 272621003798 GTP binding site [chemical binding]; other site 272621003799 Signal peptide binding domain; Region: SRP_SPB; pfam02978 272621003800 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; cl17893 272621003801 amino acid transporter; Region: 2A0306; TIGR00909 272621003802 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 272621003803 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 272621003804 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272621003805 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272621003806 Peptidase family C69; Region: Peptidase_C69; pfam03577 272621003807 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 272621003808 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 272621003809 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272621003810 P loop; other site 272621003811 GTP binding site [chemical binding]; other site 272621003812 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 272621003813 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272621003814 Walker A/P-loop; other site 272621003815 ATP binding site [chemical binding]; other site 272621003816 Q-loop/lid; other site 272621003817 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 272621003818 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 272621003819 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272621003820 ABC transporter signature motif; other site 272621003821 Walker B; other site 272621003822 D-loop; other site 272621003823 H-loop/switch region; other site 272621003824 ribonuclease III; Reviewed; Region: rnc; PRK00102 272621003825 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 272621003826 dimerization interface [polypeptide binding]; other site 272621003827 active site 272621003828 metal binding site [ion binding]; metal-binding site 272621003829 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 272621003830 dsRNA binding site [nucleotide binding]; other site 272621003831 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272621003832 Transposase; Region: HTH_Tnp_1; cl17663 272621003833 HTH-like domain; Region: HTH_21; pfam13276 272621003834 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272621003835 Integrase core domain; Region: rve; pfam00665 272621003836 Integrase core domain; Region: rve_2; pfam13333 272621003837 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272621003838 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 272621003839 peptide binding site [polypeptide binding]; other site 272621003840 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272621003841 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 272621003842 peptide binding site [polypeptide binding]; other site 272621003843 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272621003844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272621003845 dimer interface [polypeptide binding]; other site 272621003846 conserved gate region; other site 272621003847 putative PBP binding loops; other site 272621003848 ABC-ATPase subunit interface; other site 272621003849 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272621003850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272621003851 dimer interface [polypeptide binding]; other site 272621003852 conserved gate region; other site 272621003853 putative PBP binding loops; other site 272621003854 ABC-ATPase subunit interface; other site 272621003855 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272621003856 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 272621003857 Walker A/P-loop; other site 272621003858 ATP binding site [chemical binding]; other site 272621003859 Q-loop/lid; other site 272621003860 ABC transporter signature motif; other site 272621003861 Walker B; other site 272621003862 D-loop; other site 272621003863 H-loop/switch region; other site 272621003864 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272621003865 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272621003866 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272621003867 Walker A/P-loop; other site 272621003868 ATP binding site [chemical binding]; other site 272621003869 Q-loop/lid; other site 272621003870 ABC transporter signature motif; other site 272621003871 Walker B; other site 272621003872 D-loop; other site 272621003873 H-loop/switch region; other site 272621003874 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272621003875 acyl carrier protein; Provisional; Region: acpP; PRK00982 272621003876 putative phosphate acyltransferase; Provisional; Region: PRK05331 272621003877 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 272621003878 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 272621003879 generic binding surface II; other site 272621003880 ssDNA binding site; other site 272621003881 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272621003882 ATP binding site [chemical binding]; other site 272621003883 putative Mg++ binding site [ion binding]; other site 272621003884 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272621003885 nucleotide binding region [chemical binding]; other site 272621003886 ATP-binding site [chemical binding]; other site 272621003887 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 272621003888 DAK2 domain; Region: Dak2; pfam02734 272621003889 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 272621003890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 272621003891 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 272621003892 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 272621003893 Thiamine pyrophosphokinase; Region: TPK; cd07995 272621003894 active site 272621003895 dimerization interface [polypeptide binding]; other site 272621003896 thiamine binding site [chemical binding]; other site 272621003897 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 272621003898 substrate binding site [chemical binding]; other site 272621003899 hexamer interface [polypeptide binding]; other site 272621003900 metal binding site [ion binding]; metal-binding site 272621003901 GTPase RsgA; Reviewed; Region: PRK00098 272621003902 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 272621003903 RNA binding site [nucleotide binding]; other site 272621003904 homodimer interface [polypeptide binding]; other site 272621003905 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 272621003906 GTPase/Zn-binding domain interface [polypeptide binding]; other site 272621003907 GTP/Mg2+ binding site [chemical binding]; other site 272621003908 G4 box; other site 272621003909 G5 box; other site 272621003910 G1 box; other site 272621003911 Switch I region; other site 272621003912 G2 box; other site 272621003913 G3 box; other site 272621003914 Switch II region; other site 272621003915 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272621003916 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272621003917 active site 272621003918 ATP binding site [chemical binding]; other site 272621003919 substrate binding site [chemical binding]; other site 272621003920 activation loop (A-loop); other site 272621003921 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 272621003922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 272621003923 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 272621003924 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 272621003925 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 272621003926 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 272621003927 active site 272621003928 16S rRNA methyltransferase B; Provisional; Region: PRK14902 272621003929 NusB family; Region: NusB; pfam01029 272621003930 putative RNA binding site [nucleotide binding]; other site 272621003931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272621003932 S-adenosylmethionine binding site [chemical binding]; other site 272621003933 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 272621003934 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 272621003935 putative active site [active] 272621003936 substrate binding site [chemical binding]; other site 272621003937 putative cosubstrate binding site; other site 272621003938 catalytic site [active] 272621003939 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 272621003940 substrate binding site [chemical binding]; other site 272621003941 primosome assembly protein PriA; Validated; Region: PRK05580 272621003942 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272621003943 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272621003944 ATP binding site [chemical binding]; other site 272621003945 putative Mg++ binding site [ion binding]; other site 272621003946 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272621003947 nucleotide binding region [chemical binding]; other site 272621003948 ATP-binding site [chemical binding]; other site 272621003949 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 272621003950 Guanylate kinase; Region: Guanylate_kin; pfam00625 272621003951 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 272621003952 catalytic site [active] 272621003953 G-X2-G-X-G-K; other site 272621003954 RNA polymerase II transcription mediator complex subunit 9; Region: Med9; pfam07544 272621003955 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 272621003956 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 272621003957 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272621003958 Walker A/P-loop; other site 272621003959 ATP binding site [chemical binding]; other site 272621003960 Q-loop/lid; other site 272621003961 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272621003962 ABC transporter signature motif; other site 272621003963 Walker B; other site 272621003964 D-loop; other site 272621003965 H-loop/switch region; other site 272621003966 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 272621003967 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272621003968 RNA binding surface [nucleotide binding]; other site 272621003969 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 272621003970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272621003971 S-adenosylmethionine binding site [chemical binding]; other site 272621003972 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272621003973 substrate binding pocket [chemical binding]; other site 272621003974 chain length determination region; other site 272621003975 substrate-Mg2+ binding site; other site 272621003976 catalytic residues [active] 272621003977 aspartate-rich region 1; other site 272621003978 active site lid residues [active] 272621003979 aspartate-rich region 2; other site 272621003980 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 272621003981 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 272621003982 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 272621003983 generic binding surface II; other site 272621003984 generic binding surface I; other site 272621003985 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 272621003986 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 272621003987 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 272621003988 homodimer interface [polypeptide binding]; other site 272621003989 NADP binding site [chemical binding]; other site 272621003990 substrate binding site [chemical binding]; other site 272621003991 transcription antitermination factor NusB; Region: nusB; TIGR01951 272621003992 putative RNA binding site [nucleotide binding]; other site 272621003993 Asp23 family; Region: Asp23; pfam03780 272621003994 elongation factor P; Validated; Region: PRK00529 272621003995 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 272621003996 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 272621003997 RNA binding site [nucleotide binding]; other site 272621003998 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 272621003999 RNA binding site [nucleotide binding]; other site 272621004000 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272621004001 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272621004002 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 272621004003 active site 272621004004 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 272621004005 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 272621004006 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272621004007 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272621004008 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272621004009 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 272621004010 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 272621004011 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 272621004012 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 272621004013 homodimer interface [polypeptide binding]; other site 272621004014 substrate-cofactor binding pocket; other site 272621004015 catalytic residue [active] 272621004016 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 272621004017 active site 1 [active] 272621004018 dimer interface [polypeptide binding]; other site 272621004019 hexamer interface [polypeptide binding]; other site 272621004020 active site 2 [active] 272621004021 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272621004022 active site 272621004023 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272621004024 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272621004025 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 272621004026 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 272621004027 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 272621004028 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 272621004029 active site 272621004030 ATP binding site [chemical binding]; other site 272621004031 Phosphotransferase enzyme family; Region: APH; pfam01636 272621004032 antibiotic binding site [chemical binding]; other site 272621004033 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 272621004034 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272621004035 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 272621004036 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272621004037 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272621004038 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272621004039 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094 272621004040 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 272621004041 substrate binding pocket [chemical binding]; other site 272621004042 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 272621004043 putative ArsC-like catalytic residues; other site 272621004044 putative TRX-like catalytic residues [active] 272621004045 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272621004046 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272621004047 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272621004048 Walker A/P-loop; other site 272621004049 ATP binding site [chemical binding]; other site 272621004050 Q-loop/lid; other site 272621004051 ABC transporter signature motif; other site 272621004052 Walker B; other site 272621004053 D-loop; other site 272621004054 H-loop/switch region; other site 272621004055 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272621004056 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272621004057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272621004058 Walker A/P-loop; other site 272621004059 ATP binding site [chemical binding]; other site 272621004060 Q-loop/lid; other site 272621004061 ABC transporter signature motif; other site 272621004062 Walker B; other site 272621004063 D-loop; other site 272621004064 H-loop/switch region; other site 272621004065 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272621004066 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272621004067 active site 272621004068 motif I; other site 272621004069 motif II; other site 272621004070 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272621004071 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 272621004072 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 272621004073 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 272621004074 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 272621004075 putative alpha-glucosidase; Provisional; Region: PRK10658 272621004076 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 272621004077 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 272621004078 active site 272621004079 homotrimer interface [polypeptide binding]; other site 272621004080 catalytic site [active] 272621004081 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 272621004082 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 272621004083 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272621004084 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272621004085 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272621004086 nucleotide binding site [chemical binding]; other site 272621004087 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272621004088 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272621004089 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272621004090 Bacterial PH domain; Region: bPH_3; pfam14470 272621004091 Short C-terminal domain; Region: SHOCT; pfam09851 272621004092 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 272621004093 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272621004094 non-specific DNA binding site [nucleotide binding]; other site 272621004095 salt bridge; other site 272621004096 sequence-specific DNA binding site [nucleotide binding]; other site 272621004097 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 272621004098 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 272621004099 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 272621004100 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 272621004101 methionine sulfoxide reductase B; Provisional; Region: PRK00222 272621004102 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 272621004103 Sugar transport protein; Region: Sugar_transport; cl19288 272621004104 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 272621004105 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 272621004106 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 272621004107 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272621004108 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272621004109 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 272621004110 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272621004111 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272621004112 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 272621004113 IMP binding site; other site 272621004114 dimer interface [polypeptide binding]; other site 272621004115 interdomain contacts; other site 272621004116 partial ornithine binding site; other site 272621004117 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 272621004118 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 272621004119 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 272621004120 catalytic site [active] 272621004121 subunit interface [polypeptide binding]; other site 272621004122 dihydroorotase; Validated; Region: pyrC; PRK09357 272621004123 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272621004124 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 272621004125 active site 272621004126 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 272621004127 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272621004128 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272621004129 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272621004130 active site 272621004131 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 272621004132 heterodimer interface [polypeptide binding]; other site 272621004133 active site 272621004134 FMN binding site [chemical binding]; other site 272621004135 homodimer interface [polypeptide binding]; other site 272621004136 substrate binding site [chemical binding]; other site 272621004137 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 272621004138 active site 272621004139 dimer interface [polypeptide binding]; other site 272621004140 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272621004141 active site 272621004142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272621004143 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272621004144 NAD(P) binding site [chemical binding]; other site 272621004145 active site 272621004146 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 272621004147 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272621004148 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272621004149 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272621004150 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272621004151 motif II; other site 272621004152 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272621004153 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 272621004154 Cl- selectivity filter; other site 272621004155 Cl- binding residues [ion binding]; other site 272621004156 pore gating glutamate residue; other site 272621004157 dimer interface [polypeptide binding]; other site 272621004158 H+/Cl- coupling transport residue; other site 272621004159 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 272621004160 active site 272621004161 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 272621004162 MucBP domain; Region: MucBP; pfam06458 272621004163 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 272621004164 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272621004165 NLPA lipoprotein; Region: Lipoprotein_9; cl19159 272621004166 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 272621004167 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 272621004168 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 272621004169 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 272621004170 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272621004171 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 272621004172 peptide binding site [polypeptide binding]; other site 272621004173 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 272621004174 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272621004175 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272621004176 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272621004177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 272621004178 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 272621004179 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272621004180 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272621004181 NAD(P) binding site [chemical binding]; other site 272621004182 active site 272621004183 PemK-like protein; Region: PemK; pfam02452 272621004184 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 272621004185 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 272621004186 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272621004187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272621004188 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272621004189 dimerization interface [polypeptide binding]; other site 272621004190 FMN-binding domain; Region: FMN_bind; cl01081 272621004191 FMN-binding domain; Region: FMN_bind; pfam04205 272621004192 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 272621004193 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272621004194 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272621004195 metal binding site [ion binding]; metal-binding site 272621004196 active site 272621004197 I-site; other site 272621004198 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272621004199 EAL domain; Region: EAL; pfam00563 272621004200 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 272621004201 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 272621004202 DXD motif; other site 272621004203 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 272621004204 phosphate binding site [ion binding]; other site 272621004205 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 272621004206 Probable transposase; Region: OrfB_IS605; pfam01385 272621004207 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 272621004208 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 272621004209 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 272621004210 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 272621004211 catalytic triad [active] 272621004212 conserved cis-peptide bond; other site 272621004213 inner membrane transporter YjeM; Provisional; Region: PRK15238 272621004214 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272621004215 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272621004216 catalytic tetrad [active] 272621004217 OsmC-like protein; Region: OsmC; pfam02566 272621004218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272621004219 putative substrate translocation pore; other site 272621004220 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272621004221 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272621004222 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272621004223 dimer interface [polypeptide binding]; other site 272621004224 phosphorylation site [posttranslational modification] 272621004225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272621004226 ATP binding site [chemical binding]; other site 272621004227 Mg2+ binding site [ion binding]; other site 272621004228 G-X-G motif; other site 272621004229 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272621004230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272621004231 active site 272621004232 phosphorylation site [posttranslational modification] 272621004233 intermolecular recognition site; other site 272621004234 dimerization interface [polypeptide binding]; other site 272621004235 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 272621004236 DNA binding site [nucleotide binding] 272621004237 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272621004238 synthetase active site [active] 272621004239 NTP binding site [chemical binding]; other site 272621004240 metal binding site [ion binding]; metal-binding site 272621004241 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 272621004242 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 272621004243 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 272621004244 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 272621004245 amphipathic channel; other site 272621004246 Asn-Pro-Ala signature motifs; other site 272621004247 sucrose phosphorylase; Provisional; Region: PRK13840 272621004248 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 272621004249 active site 272621004250 homodimer interface [polypeptide binding]; other site 272621004251 catalytic site [active] 272621004252 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 272621004253 Melibiase; Region: Melibiase; pfam02065 272621004254 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 272621004255 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 272621004256 Walker A/P-loop; other site 272621004257 ATP binding site [chemical binding]; other site 272621004258 Q-loop/lid; other site 272621004259 ABC transporter signature motif; other site 272621004260 Walker B; other site 272621004261 D-loop; other site 272621004262 H-loop/switch region; other site 272621004263 TOBE domain; Region: TOBE; pfam03459 272621004264 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272621004265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272621004266 dimer interface [polypeptide binding]; other site 272621004267 conserved gate region; other site 272621004268 putative PBP binding loops; other site 272621004269 ABC-ATPase subunit interface; other site 272621004270 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272621004271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272621004272 dimer interface [polypeptide binding]; other site 272621004273 conserved gate region; other site 272621004274 putative PBP binding loops; other site 272621004275 ABC-ATPase subunit interface; other site 272621004276 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 272621004277 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272621004278 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272621004279 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272621004280 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272621004281 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 272621004282 DNA binding residues [nucleotide binding] 272621004283 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272621004284 putative dimer interface [polypeptide binding]; other site 272621004285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272621004286 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272621004287 putative substrate translocation pore; other site 272621004288 Melibiase; Region: Melibiase; pfam02065 272621004289 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 272621004290 Bacterial surface layer protein; Region: SLAP; pfam03217 272621004291 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 272621004292 active site 272621004293 catalytic residues [active] 272621004294 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 272621004295 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 272621004296 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 272621004297 galactokinase; Provisional; Region: PRK05322 272621004298 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 272621004299 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272621004300 MucBP domain; Region: MucBP; pfam06458 272621004301 MucBP domain; Region: MucBP; pfam06458 272621004302 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 272621004303 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 272621004304 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 272621004305 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 272621004306 putative symporter YagG; Provisional; Region: PRK09669; cl15392 272621004307 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 272621004308 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272621004309 HPr interaction site; other site 272621004310 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272621004311 active site 272621004312 phosphorylation site [posttranslational modification] 272621004313 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 272621004314 Probable transposase; Region: OrfB_IS605; pfam01385 272621004315 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 272621004316 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272621004317 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272621004318 DNA binding site [nucleotide binding] 272621004319 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 272621004320 putative dimerization interface [polypeptide binding]; other site 272621004321 putative ligand binding site [chemical binding]; other site 272621004322 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 272621004323 beta-D-glucuronidase; Provisional; Region: PRK10150 272621004324 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 272621004325 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 272621004326 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 272621004327 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 272621004328 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 272621004329 NAD binding site [chemical binding]; other site 272621004330 homodimer interface [polypeptide binding]; other site 272621004331 active site 272621004332 substrate binding site [chemical binding]; other site 272621004333 Filamin/ABP280 repeat; Region: Filamin; cl19759 272621004334 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 272621004335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272621004336 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272621004337 putative substrate translocation pore; other site 272621004338 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272621004339 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272621004340 DNA binding site [nucleotide binding] 272621004341 domain linker motif; other site 272621004342 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272621004343 dimerization interface [polypeptide binding]; other site 272621004344 ligand binding site [chemical binding]; other site 272621004345 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 272621004346 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 272621004347 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 272621004348 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272621004349 Transposase; Region: HTH_Tnp_1; cl17663 272621004350 HTH-like domain; Region: HTH_21; pfam13276 272621004351 Integrase core domain; Region: rve; pfam00665 272621004352 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 272621004353 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272621004354 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272621004355 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272621004356 active site turn [active] 272621004357 phosphorylation site [posttranslational modification] 272621004358 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 272621004359 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272621004360 active site turn [active] 272621004361 phosphorylation site [posttranslational modification] 272621004362 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272621004363 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272621004364 HPr interaction site; other site 272621004365 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272621004366 active site 272621004367 phosphorylation site [posttranslational modification] 272621004368 CAT RNA binding domain; Region: CAT_RBD; smart01061 272621004369 transcriptional antiterminator BglG; Provisional; Region: PRK09772 272621004370 PRD domain; Region: PRD; pfam00874 272621004371 PRD domain; Region: PRD; pfam00874 272621004372 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 272621004373 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 272621004374 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 272621004375 ligand binding site [chemical binding]; other site 272621004376 dimerization interface [polypeptide binding]; other site 272621004377 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272621004378 TM-ABC transporter signature motif; other site 272621004379 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 272621004380 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272621004381 Walker A/P-loop; other site 272621004382 ATP binding site [chemical binding]; other site 272621004383 Q-loop/lid; other site 272621004384 ABC transporter signature motif; other site 272621004385 Walker B; other site 272621004386 D-loop; other site 272621004387 H-loop/switch region; other site 272621004388 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272621004389 D-ribose pyranase; Provisional; Region: PRK11797 272621004390 adenosine kinase; Provisional; Region: PTZ00247 272621004391 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 272621004392 substrate binding site [chemical binding]; other site 272621004393 dimer interface [polypeptide binding]; other site 272621004394 ATP binding site [chemical binding]; other site 272621004395 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 272621004396 hexamer (dimer of trimers) interface [polypeptide binding]; other site 272621004397 trimer interface [polypeptide binding]; other site 272621004398 substrate binding site [chemical binding]; other site 272621004399 Mn binding site [ion binding]; other site 272621004400 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 272621004401 Probable transposase; Region: OrfB_IS605; pfam01385 272621004402 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 272621004403 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272621004404 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272621004405 DNA binding site [nucleotide binding] 272621004406 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272621004407 ligand binding site [chemical binding]; other site 272621004408 dimerization interface [polypeptide binding]; other site 272621004409 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272621004410 TPP-binding site [chemical binding]; other site 272621004411 dimer interface [polypeptide binding]; other site 272621004412 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 272621004413 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272621004414 PYR/PP interface [polypeptide binding]; other site 272621004415 dimer interface [polypeptide binding]; other site 272621004416 TPP binding site [chemical binding]; other site 272621004417 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272621004418 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 272621004419 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272621004420 nucleotide binding site [chemical binding]; other site 272621004421 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 272621004422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272621004423 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272621004424 putative substrate translocation pore; other site 272621004425 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 272621004426 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 272621004427 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 272621004428 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272621004429 Walker A/P-loop; other site 272621004430 ATP binding site [chemical binding]; other site 272621004431 Q-loop/lid; other site 272621004432 ABC transporter signature motif; other site 272621004433 Walker B; other site 272621004434 D-loop; other site 272621004435 H-loop/switch region; other site 272621004436 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 272621004437 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 272621004438 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 272621004439 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 272621004440 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 272621004441 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272621004442 catalytic residue [active] 272621004443 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 272621004444 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272621004445 active site residue [active] 272621004446 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 272621004447 Rhomboid family; Region: Rhomboid; pfam01694 272621004448 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 272621004449 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 272621004450 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 272621004451 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 272621004452 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272621004453 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 272621004454 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272621004455 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272621004456 nucleotide binding site [chemical binding]; other site 272621004457 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 272621004458 Subtilase family; Region: Peptidase_S8; pfam00082 272621004459 catalytic triad [active] 272621004460 putative active site [active] 272621004461 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 272621004462 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 272621004463 Bacterial surface layer protein; Region: SLAP; pfam03217 272621004464 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 272621004465 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 272621004466 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 272621004467 peptidase T-like protein; Region: PepT-like; TIGR01883 272621004468 metal binding site [ion binding]; metal-binding site 272621004469 dimer interface [polypeptide binding]; other site 272621004470 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 272621004471 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272621004472 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 272621004473 NAD binding site [chemical binding]; other site 272621004474 dimer interface [polypeptide binding]; other site 272621004475 substrate binding site [chemical binding]; other site 272621004476 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 272621004477 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 272621004478 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272621004479 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 272621004480 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272621004481 putative tRNA-binding site [nucleotide binding]; other site 272621004482 B3/4 domain; Region: B3_4; pfam03483 272621004483 tRNA synthetase B5 domain; Region: B5; smart00874 272621004484 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 272621004485 dimer interface [polypeptide binding]; other site 272621004486 motif 1; other site 272621004487 motif 3; other site 272621004488 motif 2; other site 272621004489 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 272621004490 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 272621004491 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 272621004492 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 272621004493 dimer interface [polypeptide binding]; other site 272621004494 motif 1; other site 272621004495 active site 272621004496 motif 2; other site 272621004497 motif 3; other site 272621004498 Predicted transcriptional regulators [Transcription]; Region: COG1733 272621004499 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 272621004500 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 272621004501 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272621004502 Acylphosphatase; Region: Acylphosphatase; pfam00708 272621004503 OxaA-like protein precursor; Provisional; Region: PRK02463 272621004504 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 272621004505 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272621004506 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272621004507 dimerization interface [polypeptide binding]; other site 272621004508 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272621004509 dimer interface [polypeptide binding]; other site 272621004510 phosphorylation site [posttranslational modification] 272621004511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272621004512 ATP binding site [chemical binding]; other site 272621004513 Mg2+ binding site [ion binding]; other site 272621004514 G-X-G motif; other site 272621004515 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272621004516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272621004517 active site 272621004518 phosphorylation site [posttranslational modification] 272621004519 intermolecular recognition site; other site 272621004520 dimerization interface [polypeptide binding]; other site 272621004521 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272621004522 DNA binding site [nucleotide binding] 272621004523 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 272621004524 hypothetical protein; Provisional; Region: PRK13670 272621004525 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 272621004526 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 272621004527 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272621004528 Zn2+ binding site [ion binding]; other site 272621004529 Mg2+ binding site [ion binding]; other site 272621004530 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 272621004531 active site 272621004532 (T/H)XGH motif; other site 272621004533 GTPase YqeH; Provisional; Region: PRK13796 272621004534 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 272621004535 GTP/Mg2+ binding site [chemical binding]; other site 272621004536 G4 box; other site 272621004537 G5 box; other site 272621004538 G1 box; other site 272621004539 Switch I region; other site 272621004540 G2 box; other site 272621004541 G3 box; other site 272621004542 Switch II region; other site 272621004543 Baseplate J-like protein; Region: Baseplate_J; cl01294 272621004544 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272621004545 active site 272621004546 motif I; other site 272621004547 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 272621004548 motif II; other site 272621004549 adenosine deaminase; Provisional; Region: PRK09358 272621004550 active site 272621004551 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 272621004552 23S rRNA binding site [nucleotide binding]; other site 272621004553 L21 binding site [polypeptide binding]; other site 272621004554 L13 binding site [polypeptide binding]; other site 272621004555 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 272621004556 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 272621004557 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 272621004558 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 272621004559 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 272621004560 LytTr DNA-binding domain; Region: LytTR; smart00850 272621004561 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 272621004562 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 272621004563 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 272621004564 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 272621004565 active site 272621004566 dimer interface [polypeptide binding]; other site 272621004567 motif 1; other site 272621004568 motif 2; other site 272621004569 motif 3; other site 272621004570 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 272621004571 anticodon binding site; other site 272621004572 primosomal protein DnaI; Reviewed; Region: PRK08939 272621004573 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 272621004574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272621004575 Walker A motif; other site 272621004576 ATP binding site [chemical binding]; other site 272621004577 Walker B motif; other site 272621004578 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 272621004579 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 272621004580 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 272621004581 ATP cone domain; Region: ATP-cone; pfam03477 272621004582 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 272621004583 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 272621004584 CoA-binding site [chemical binding]; other site 272621004585 ATP-binding [chemical binding]; other site 272621004586 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 272621004587 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 272621004588 DNA binding site [nucleotide binding] 272621004589 catalytic residue [active] 272621004590 H2TH interface [polypeptide binding]; other site 272621004591 putative catalytic residues [active] 272621004592 turnover-facilitating residue; other site 272621004593 intercalation triad [nucleotide binding]; other site 272621004594 8OG recognition residue [nucleotide binding]; other site 272621004595 putative reading head residues; other site 272621004596 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 272621004597 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 272621004598 DNA polymerase I; Provisional; Region: PRK05755 272621004599 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 272621004600 active site 272621004601 metal binding site 1 [ion binding]; metal-binding site 272621004602 putative 5' ssDNA interaction site; other site 272621004603 metal binding site 3; metal-binding site 272621004604 metal binding site 2 [ion binding]; metal-binding site 272621004605 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 272621004606 putative DNA binding site [nucleotide binding]; other site 272621004607 putative metal binding site [ion binding]; other site 272621004608 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 272621004609 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 272621004610 active site 272621004611 DNA binding site [nucleotide binding] 272621004612 catalytic site [active] 272621004613 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 272621004614 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 272621004615 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272621004616 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 272621004617 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 272621004618 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 272621004619 purine monophosphate binding site [chemical binding]; other site 272621004620 dimer interface [polypeptide binding]; other site 272621004621 putative catalytic residues [active] 272621004622 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 272621004623 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 272621004624 active site 272621004625 substrate binding site [chemical binding]; other site 272621004626 cosubstrate binding site; other site 272621004627 catalytic site [active] 272621004628 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 272621004629 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 272621004630 dimerization interface [polypeptide binding]; other site 272621004631 putative ATP binding site [chemical binding]; other site 272621004632 amidophosphoribosyltransferase; Provisional; Region: PRK07272 272621004633 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 272621004634 active site 272621004635 tetramer interface [polypeptide binding]; other site 272621004636 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272621004637 active site 272621004638 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 272621004639 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 272621004640 dimerization interface [polypeptide binding]; other site 272621004641 ATP binding site [chemical binding]; other site 272621004642 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 272621004643 dimerization interface [polypeptide binding]; other site 272621004644 ATP binding site [chemical binding]; other site 272621004645 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 272621004646 putative active site [active] 272621004647 catalytic triad [active] 272621004648 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 272621004649 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 272621004650 ATP binding site [chemical binding]; other site 272621004651 active site 272621004652 substrate binding site [chemical binding]; other site 272621004653 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 272621004654 ATP-grasp domain; Region: ATP-grasp; pfam02222 272621004655 AIR carboxylase; Region: AIRC; pfam00731 272621004656 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 272621004657 Potassium binding sites [ion binding]; other site 272621004658 Cesium cation binding sites [ion binding]; other site 272621004659 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272621004660 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 272621004661 SPFH domain / Band 7 family; Region: Band_7; pfam01145 272621004662 RelB antitoxin; Region: RelB; cl01171 272621004663 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 272621004664 Zn binding site [ion binding]; other site 272621004665 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272621004666 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 272621004667 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 272621004668 active site 272621004669 Mn binding site [ion binding]; other site 272621004670 Predicted membrane protein [Function unknown]; Region: COG2364 272621004671 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272621004672 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272621004673 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 272621004674 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272621004675 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272621004676 HPr interaction site; other site 272621004677 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272621004678 active site 272621004679 phosphorylation site [posttranslational modification] 272621004680 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272621004681 active site turn [active] 272621004682 phosphorylation site [posttranslational modification] 272621004683 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272621004684 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272621004685 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272621004686 putative active site [active] 272621004687 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 272621004688 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272621004689 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272621004690 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272621004691 Domain of unknown function (DUF4479); Region: DUF4479; pfam14794 272621004692 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272621004693 putative tRNA-binding site [nucleotide binding]; other site 272621004694 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272621004695 catalytic residues [active] 272621004696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272621004697 S-adenosylmethionine binding site [chemical binding]; other site 272621004698 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 272621004699 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272621004700 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272621004701 Walker A/P-loop; other site 272621004702 ATP binding site [chemical binding]; other site 272621004703 Q-loop/lid; other site 272621004704 ABC transporter signature motif; other site 272621004705 Walker B; other site 272621004706 D-loop; other site 272621004707 H-loop/switch region; other site 272621004708 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 272621004709 HIT family signature motif; other site 272621004710 catalytic residue [active] 272621004711 YtxH-like protein; Region: YtxH; cl02079 272621004712 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 272621004713 SurA N-terminal domain; Region: SurA_N_3; cl07813 272621004714 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 272621004715 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 272621004716 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 272621004717 generic binding surface I; other site 272621004718 generic binding surface II; other site 272621004719 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272621004720 Zn2+ binding site [ion binding]; other site 272621004721 Mg2+ binding site [ion binding]; other site 272621004722 Uncharacterized conserved protein [Function unknown]; Region: COG4717 272621004723 AAA domain; Region: AAA_23; pfam13476 272621004724 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314; cl02193 272621004725 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 272621004726 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 272621004727 active site 272621004728 metal binding site [ion binding]; metal-binding site 272621004729 DNA binding site [nucleotide binding] 272621004730 hypothetical protein; Provisional; Region: PRK13676 272621004731 Transglycosylase; Region: Transgly; pfam00912 272621004732 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 272621004733 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272621004734 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272621004735 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272621004736 active site 272621004737 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 272621004738 amphipathic channel; other site 272621004739 Asn-Pro-Ala signature motifs; other site 272621004740 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 272621004741 active site 272621004742 substrate binding site [chemical binding]; other site 272621004743 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 272621004744 FMN binding site [chemical binding]; other site 272621004745 putative catalytic residues [active] 272621004746 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 272621004747 intersubunit interface [polypeptide binding]; other site 272621004748 active site 272621004749 zinc binding site [ion binding]; other site 272621004750 Na+ binding site [ion binding]; other site 272621004751 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 272621004752 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 272621004753 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 272621004754 active site 272621004755 HIGH motif; other site 272621004756 KMSK motif region; other site 272621004757 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 272621004758 tRNA binding surface [nucleotide binding]; other site 272621004759 anticodon binding site; other site 272621004760 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 272621004761 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272621004762 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 272621004763 putative substrate binding site [chemical binding]; other site 272621004764 putative ATP binding site [chemical binding]; other site 272621004765 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 272621004766 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 272621004767 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 272621004768 PspC domain; Region: PspC; pfam04024 272621004769 Beta-lactamase; Region: Beta-lactamase; pfam00144 272621004770 Tic20-like protein; Region: Tic20; pfam09685 272621004771 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 272621004772 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 272621004773 Enterocin A Immunity; Region: EntA_Immun; pfam08951 272621004774 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 272621004775 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 272621004776 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 272621004777 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 272621004778 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 272621004779 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 272621004780 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 272621004781 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 272621004782 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 272621004783 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 272621004784 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 272621004785 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 272621004786 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 272621004787 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 272621004788 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 272621004789 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 272621004790 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 272621004791 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272621004792 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 272621004793 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 272621004794 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 272621004795 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 272621004796 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 272621004797 active site 272621004798 HIGH motif; other site 272621004799 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272621004800 KMSKS motif; other site 272621004801 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 272621004802 tRNA binding surface [nucleotide binding]; other site 272621004803 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 272621004804 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272621004805 active site 272621004806 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 272621004807 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272621004808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272621004809 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272621004810 putative substrate translocation pore; other site 272621004811 S-adenosylmethionine synthetase; Validated; Region: PRK05250 272621004812 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 272621004813 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 272621004814 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 272621004815 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 272621004816 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 272621004817 intersubunit interface [polypeptide binding]; other site 272621004818 seryl-tRNA synthetase; Provisional; Region: PRK05431 272621004819 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 272621004820 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 272621004821 dimer interface [polypeptide binding]; other site 272621004822 active site 272621004823 motif 1; other site 272621004824 motif 2; other site 272621004825 motif 3; other site 272621004826 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272621004827 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272621004828 Uncharacterized conserved protein [Function unknown]; Region: COG0398 272621004829 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272621004830 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272621004831 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272621004832 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272621004833 non-specific DNA binding site [nucleotide binding]; other site 272621004834 salt bridge; other site 272621004835 sequence-specific DNA binding site [nucleotide binding]; other site 272621004836 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 272621004837 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 272621004838 NAD(P) binding site [chemical binding]; other site 272621004839 catalytic residues [active] 272621004840 Rib/alpha-like repeat; Region: Rib; cl07159 272621004841 Cadherin repeat-like domain; Region: CA_like; cl15786 272621004842 Rib/alpha-like repeat; Region: Rib; pfam08428 272621004843 Rib/alpha-like repeat; Region: Rib; cl07159 272621004844 Rib/alpha-like repeat; Region: Rib; pfam08428 272621004845 Rib/alpha-like repeat; Region: Rib; pfam08428 272621004846 Rib/alpha-like repeat; Region: Rib; pfam08428 272621004847 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 272621004848 Rib/alpha-like repeat; Region: Rib; pfam08428 272621004849 Rib/alpha-like repeat; Region: Rib; pfam08428 272621004850 Rib/alpha-like repeat; Region: Rib; pfam08428 272621004851 Rib/alpha-like repeat; Region: Rib; pfam08428 272621004852 Rib/alpha-like repeat; Region: Rib; pfam08428 272621004853 Double zinc ribbon; Region: DZR; pfam12773 272621004854 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 272621004855 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 272621004856 MMPL family; Region: MMPL; cl14618 272621004857 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 272621004858 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 272621004859 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 272621004860 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 272621004861 MMPL family; Region: MMPL; cl14618 272621004862 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272621004863 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272621004864 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 272621004865 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 272621004866 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 272621004867 Cl binding site [ion binding]; other site 272621004868 oligomer interface [polypeptide binding]; other site 272621004869 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272621004870 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 272621004871 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272621004872 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 272621004873 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 272621004874 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272621004875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272621004876 dimer interface [polypeptide binding]; other site 272621004877 conserved gate region; other site 272621004878 putative PBP binding loops; other site 272621004879 ABC-ATPase subunit interface; other site 272621004880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272621004881 dimer interface [polypeptide binding]; other site 272621004882 conserved gate region; other site 272621004883 putative PBP binding loops; other site 272621004884 ABC-ATPase subunit interface; other site 272621004885 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 272621004886 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272621004887 Walker A/P-loop; other site 272621004888 ATP binding site [chemical binding]; other site 272621004889 Q-loop/lid; other site 272621004890 ABC transporter signature motif; other site 272621004891 Walker B; other site 272621004892 D-loop; other site 272621004893 H-loop/switch region; other site 272621004894 TOBE domain; Region: TOBE_2; pfam08402 272621004895 Peptidase family C69; Region: Peptidase_C69; pfam03577 272621004896 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 272621004897 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 272621004898 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272621004899 active site 272621004900 catalytic site [active] 272621004901 substrate binding site [chemical binding]; other site 272621004902 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 272621004903 Predicted membrane protein [Function unknown]; Region: COG2323 272621004904 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 272621004905 Glucan-binding protein C; Region: GbpC; pfam08363 272621004906 MucBP domain; Region: MucBP; pfam06458 272621004907 MucBP domain; Region: MucBP; pfam06458 272621004908 MucBP domain; Region: MucBP; pfam06458 272621004909 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 272621004910 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 272621004911 Procyclic acidic repetitive protein (PARP); Region: Trypan_PARP; pfam05887 272621004912 PAS domain; Region: PAS_10; pfam13596 272621004913 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272621004914 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272621004915 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 272621004916 Walker A/P-loop; other site 272621004917 ATP binding site [chemical binding]; other site 272621004918 Q-loop/lid; other site 272621004919 ABC transporter signature motif; other site 272621004920 Walker B; other site 272621004921 D-loop; other site 272621004922 H-loop/switch region; other site 272621004923 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 272621004924 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272621004925 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272621004926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272621004927 active site 272621004928 phosphorylation site [posttranslational modification] 272621004929 intermolecular recognition site; other site 272621004930 dimerization interface [polypeptide binding]; other site 272621004931 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272621004932 DNA binding site [nucleotide binding] 272621004933 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272621004934 HAMP domain; Region: HAMP; pfam00672 272621004935 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272621004936 dimer interface [polypeptide binding]; other site 272621004937 phosphorylation site [posttranslational modification] 272621004938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272621004939 ATP binding site [chemical binding]; other site 272621004940 Mg2+ binding site [ion binding]; other site 272621004941 G-X-G motif; other site 272621004942 Predicted membrane protein [Function unknown]; Region: COG3212 272621004943 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 272621004944 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 272621004945 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 272621004946 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 272621004947 Transcriptional regulators [Transcription]; Region: MarR; COG1846 272621004948 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 272621004949 putative DNA binding site [nucleotide binding]; other site 272621004950 putative Zn2+ binding site [ion binding]; other site 272621004951 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272621004952 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272621004953 Coenzyme A binding pocket [chemical binding]; other site 272621004954 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272621004955 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272621004956 peptide binding site [polypeptide binding]; other site 272621004957 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 272621004958 Predicted membrane protein [Function unknown]; Region: COG3212 272621004959 elongation factor P; Validated; Region: PRK00529 272621004960 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 272621004961 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 272621004962 RNA binding site [nucleotide binding]; other site 272621004963 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 272621004964 RNA binding site [nucleotide binding]; other site 272621004965 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 272621004966 ATP-binding site [chemical binding]; other site 272621004967 CoA-binding site [chemical binding]; other site 272621004968 Mg2+-binding site [ion binding]; other site 272621004969 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 272621004970 active site 272621004971 catalytic triad [active] 272621004972 oxyanion hole [active] 272621004973 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272621004974 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272621004975 Coenzyme A binding pocket [chemical binding]; other site 272621004976 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272621004977 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272621004978 substrate binding pocket [chemical binding]; other site 272621004979 membrane-bound complex binding site; other site 272621004980 hinge residues; other site 272621004981 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272621004982 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272621004983 Walker A/P-loop; other site 272621004984 ATP binding site [chemical binding]; other site 272621004985 Q-loop/lid; other site 272621004986 ABC transporter signature motif; other site 272621004987 Walker B; other site 272621004988 D-loop; other site 272621004989 H-loop/switch region; other site 272621004990 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 272621004991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272621004992 dimer interface [polypeptide binding]; other site 272621004993 conserved gate region; other site 272621004994 putative PBP binding loops; other site 272621004995 ABC-ATPase subunit interface; other site 272621004996 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 272621004997 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 272621004998 Part of AAA domain; Region: AAA_19; pfam13245 272621004999 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 272621005000 active site 272621005001 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272621005002 catalytic core [active] 272621005003 FtsX-like permease family; Region: FtsX; pfam02687 272621005004 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272621005005 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272621005006 Walker A/P-loop; other site 272621005007 ATP binding site [chemical binding]; other site 272621005008 Q-loop/lid; other site 272621005009 ABC transporter signature motif; other site 272621005010 Walker B; other site 272621005011 D-loop; other site 272621005012 H-loop/switch region; other site 272621005013 Predicted membrane protein [Function unknown]; Region: COG4640 272621005014 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 272621005015 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 272621005016 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272621005017 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272621005018 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272621005019 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272621005020 motif II; other site 272621005021 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272621005022 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 272621005023 active pocket/dimerization site; other site 272621005024 active site 272621005025 phosphorylation site [posttranslational modification] 272621005026 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 272621005027 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 272621005028 active site 272621005029 homodimer interface [polypeptide binding]; other site 272621005030 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272621005031 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272621005032 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272621005033 putative active site [active] 272621005034 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 272621005035 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 272621005036 NAD(P) binding site [chemical binding]; other site 272621005037 LDH/MDH dimer interface [polypeptide binding]; other site 272621005038 substrate binding site [chemical binding]; other site 272621005039 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 272621005040 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272621005041 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272621005042 Coenzyme A binding pocket [chemical binding]; other site 272621005043 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272621005044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272621005045 homodimer interface [polypeptide binding]; other site 272621005046 catalytic residue [active] 272621005047 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 272621005048 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 272621005049 TrkA-C domain; Region: TrkA_C; pfam02080 272621005050 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 272621005051 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 272621005052 active site 272621005053 putative catalytic site [active] 272621005054 DNA binding site [nucleotide binding] 272621005055 putative phosphate binding site [ion binding]; other site 272621005056 metal binding site A [ion binding]; metal-binding site 272621005057 AP binding site [nucleotide binding]; other site 272621005058 metal binding site B [ion binding]; metal-binding site 272621005059 Cupin domain; Region: Cupin_2; cl17218 272621005060 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272621005061 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272621005062 Cupin domain; Region: Cupin_2; cl17218 272621005063 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272621005064 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272621005065 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272621005066 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272621005067 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272621005068 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272621005069 putative active site [active] 272621005070 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 272621005071 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 272621005072 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 272621005073 putative active site [active] 272621005074 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 272621005075 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272621005076 active site turn [active] 272621005077 phosphorylation site [posttranslational modification] 272621005078 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272621005079 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272621005080 HPr interaction site; other site 272621005081 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272621005082 active site 272621005083 phosphorylation site [posttranslational modification] 272621005084 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 272621005085 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272621005086 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 272621005087 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272621005088 active site turn [active] 272621005089 phosphorylation site [posttranslational modification] 272621005090 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272621005091 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 272621005092 HPr interaction site; other site 272621005093 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272621005094 active site 272621005095 phosphorylation site [posttranslational modification] 272621005096 transcriptional antiterminator BglG; Provisional; Region: PRK09772 272621005097 CAT RNA binding domain; Region: CAT_RBD; smart01061 272621005098 PRD domain; Region: PRD; pfam00874 272621005099 PRD domain; Region: PRD; pfam00874 272621005100 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 272621005101 MucBP domain; Region: MucBP; pfam06458 272621005102 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 272621005103 carbohydrate binding site [chemical binding]; other site 272621005104 pullulanase, type I; Region: pulA_typeI; TIGR02104 272621005105 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 272621005106 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 272621005107 Ca binding site [ion binding]; other site 272621005108 active site 272621005109 catalytic site [active] 272621005110 Bacterial surface layer protein; Region: SLAP; pfam03217 272621005111 Predicted ATPase [General function prediction only]; Region: COG5293 272621005112 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 272621005113 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 272621005114 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 272621005115 active site 272621005116 tetramer interface; other site 272621005117 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 272621005118 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 272621005119 active site 272621005120 homodimer interface [polypeptide binding]; other site 272621005121 Integrase core domain; Region: rve; pfam00665 272621005122 Integrase core domain; Region: rve_2; pfam13333 272621005123 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272621005124 Helix-turn-helix domain; Region: HTH_28; pfam13518 272621005125 Transposase; Region: DEDD_Tnp_IS110; pfam01548 272621005126 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 272621005127 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 272621005128 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 272621005129 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 272621005130 UDP-galactopyranose mutase; Region: GLF; pfam03275 272621005131 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272621005132 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272621005133 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272621005134 active site 272621005135 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272621005136 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272621005137 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272621005138 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 272621005139 Probable Catalytic site; other site 272621005140 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 272621005141 Bacterial sugar transferase; Region: Bac_transf; pfam02397 272621005142 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 272621005143 PHP domain; Region: PHP; pfam02811 272621005144 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 272621005145 AAA domain; Region: AAA_31; pfam13614 272621005146 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 272621005147 Chain length determinant protein; Region: Wzz; pfam02706 272621005148 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 272621005149 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 272621005150 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 272621005151 HflX GTPase family; Region: HflX; cd01878 272621005152 G1 box; other site 272621005153 GTP/Mg2+ binding site [chemical binding]; other site 272621005154 Switch I region; other site 272621005155 G2 box; other site 272621005156 G3 box; other site 272621005157 Switch II region; other site 272621005158 G4 box; other site 272621005159 G5 box; other site 272621005160 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 272621005161 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 272621005162 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 272621005163 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272621005164 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 272621005165 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 272621005166 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272621005167 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 272621005168 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 272621005169 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272621005170 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 272621005171 Matrix protein (MA), p15; Region: Gag_MA; pfam01140 272621005172 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 272621005173 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 272621005174 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272621005175 NlpC/P60 family; Region: NLPC_P60; pfam00877 272621005176 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272621005177 NlpC/P60 family; Region: NLPC_P60; pfam00877 272621005178 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272621005179 NlpC/P60 family; Region: NLPC_P60; pfam00877 272621005180 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 272621005181 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 272621005182 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 272621005183 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 272621005184 dimer interface [polypeptide binding]; other site 272621005185 putative radical transfer pathway; other site 272621005186 diiron center [ion binding]; other site 272621005187 tyrosyl radical; other site 272621005188 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 272621005189 putative active site [active] 272621005190 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 272621005191 Uncharacterized protein family (UPF0051); Region: UPF0051; cl19515 272621005192 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272621005193 Walker A/P-loop; other site 272621005194 ATP binding site [chemical binding]; other site 272621005195 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 272621005196 Uncharacterized conserved protein [Function unknown]; Region: COG2966 272621005197 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 272621005198 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272621005199 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272621005200 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272621005201 Walker A/P-loop; other site 272621005202 ATP binding site [chemical binding]; other site 272621005203 Q-loop/lid; other site 272621005204 ABC transporter signature motif; other site 272621005205 Walker B; other site 272621005206 ABC transporter; Region: ABC_tran_2; pfam12848 272621005207 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272621005208 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 272621005209 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 272621005210 oligoendopeptidase F; Region: pepF; TIGR00181 272621005211 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 272621005212 active site 272621005213 Zn binding site [ion binding]; other site 272621005214 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 272621005215 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 272621005216 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 272621005217 ABC-ATPase subunit interface; other site 272621005218 dimer interface [polypeptide binding]; other site 272621005219 putative PBP binding regions; other site 272621005220 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272621005221 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272621005222 Walker A/P-loop; other site 272621005223 ATP binding site [chemical binding]; other site 272621005224 Q-loop/lid; other site 272621005225 ABC transporter signature motif; other site 272621005226 Walker B; other site 272621005227 D-loop; other site 272621005228 H-loop/switch region; other site 272621005229 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 272621005230 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 272621005231 intersubunit interface [polypeptide binding]; other site 272621005232 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272621005233 dimerization interface [polypeptide binding]; other site 272621005234 putative DNA binding site [nucleotide binding]; other site 272621005235 putative Zn2+ binding site [ion binding]; other site 272621005236 LytTr DNA-binding domain; Region: LytTR; smart00850 272621005237 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 272621005238 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 272621005239 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272621005240 active site 272621005241 phosphorylation site [posttranslational modification] 272621005242 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 272621005243 active site 272621005244 P-loop; other site 272621005245 phosphorylation site [posttranslational modification] 272621005246 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 272621005247 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 272621005248 putative substrate binding site [chemical binding]; other site 272621005249 putative ATP binding site [chemical binding]; other site 272621005250 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272621005251 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 272621005252 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272621005253 Fic family protein [Function unknown]; Region: COG3177 272621005254 Fic/DOC family; Region: Fic; pfam02661 272621005255 Fic/DOC family; Region: Fic; cl00960 272621005256 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 272621005257 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 272621005258 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272621005259 Walker A/P-loop; other site 272621005260 ATP binding site [chemical binding]; other site 272621005261 Q-loop/lid; other site 272621005262 ABC transporter signature motif; other site 272621005263 Walker B; other site 272621005264 D-loop; other site 272621005265 H-loop/switch region; other site 272621005266 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 272621005267 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272621005268 salt bridge; other site 272621005269 non-specific DNA binding site [nucleotide binding]; other site 272621005270 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272621005271 sequence-specific DNA binding site [nucleotide binding]; other site 272621005272 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272621005273 catalytic residues [active] 272621005274 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 272621005275 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 272621005276 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 272621005277 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 272621005278 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 272621005279 putative active site [active] 272621005280 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272621005281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272621005282 Walker A/P-loop; other site 272621005283 ATP binding site [chemical binding]; other site 272621005284 Q-loop/lid; other site 272621005285 ABC transporter signature motif; other site 272621005286 Walker B; other site 272621005287 D-loop; other site 272621005288 H-loop/switch region; other site 272621005289 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 272621005290 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 272621005291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272621005292 active site 272621005293 phosphorylation site [posttranslational modification] 272621005294 intermolecular recognition site; other site 272621005295 dimerization interface [polypeptide binding]; other site 272621005296 LytTr DNA-binding domain; Region: LytTR; smart00850 272621005297 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 272621005298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 272621005299 CAAX protease self-immunity; Region: Abi; pfam02517 272621005300 Enterocin A Immunity; Region: EntA_Immun; pfam08951 272621005301 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 272621005302 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 272621005303 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 272621005304 trimer interface [polypeptide binding]; other site 272621005305 active site 272621005306 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 272621005307 catalytic site [active] 272621005308 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 272621005309 Enterocin A Immunity; Region: EntA_Immun; pfam08951 272621005310 Enterocin A Immunity; Region: EntA_Immun; pfam08951 272621005311 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 272621005312 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 272621005313 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272621005314 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272621005315 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272621005316 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272621005317 HAMP domain; Region: HAMP; pfam00672 272621005318 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272621005319 dimer interface [polypeptide binding]; other site 272621005320 phosphorylation site [posttranslational modification] 272621005321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272621005322 ATP binding site [chemical binding]; other site 272621005323 Mg2+ binding site [ion binding]; other site 272621005324 G-X-G motif; other site 272621005325 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272621005326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272621005327 active site 272621005328 phosphorylation site [posttranslational modification] 272621005329 intermolecular recognition site; other site 272621005330 dimerization interface [polypeptide binding]; other site 272621005331 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272621005332 DNA binding site [nucleotide binding] 272621005333 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272621005334 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272621005335 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 272621005336 Walker A/P-loop; other site 272621005337 ATP binding site [chemical binding]; other site 272621005338 Q-loop/lid; other site 272621005339 ABC transporter signature motif; other site 272621005340 Walker B; other site 272621005341 D-loop; other site 272621005342 H-loop/switch region; other site 272621005343 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272621005344 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272621005345 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272621005346 Walker A/P-loop; other site 272621005347 ATP binding site [chemical binding]; other site 272621005348 Q-loop/lid; other site 272621005349 ABC transporter signature motif; other site 272621005350 Walker B; other site 272621005351 D-loop; other site 272621005352 H-loop/switch region; other site 272621005353 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 272621005354 GTP-binding protein YchF; Reviewed; Region: PRK09601 272621005355 YchF GTPase; Region: YchF; cd01900 272621005356 G1 box; other site 272621005357 GTP/Mg2+ binding site [chemical binding]; other site 272621005358 Switch I region; other site 272621005359 G2 box; other site 272621005360 Switch II region; other site 272621005361 G3 box; other site 272621005362 G4 box; other site 272621005363 G5 box; other site 272621005364 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 272621005365 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 272621005366 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 272621005367 ParB-like nuclease domain; Region: ParB; smart00470 272621005368 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 272621005369 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272621005370 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272621005371 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272621005372 P-loop; other site 272621005373 Magnesium ion binding site [ion binding]; other site 272621005374 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 272621005375 ParB-like nuclease domain; Region: ParB; smart00470 272621005376 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 272621005377 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272621005378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272621005379 S-adenosylmethionine binding site [chemical binding]; other site 272621005380 Colicin V production protein; Region: Colicin_V; pfam02674 272621005381 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 272621005382 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 272621005383 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 272621005384 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 272621005385 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272621005386 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272621005387 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272621005388 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 272621005389 WHG domain; Region: WHG; pfam13305 272621005390 Peptidase family C69; Region: Peptidase_C69; cl17793 272621005391 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 272621005392 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272621005393 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272621005394 Walker A/P-loop; other site 272621005395 ATP binding site [chemical binding]; other site 272621005396 Q-loop/lid; other site 272621005397 ABC transporter signature motif; other site 272621005398 Walker B; other site 272621005399 D-loop; other site 272621005400 H-loop/switch region; other site 272621005401 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272621005402 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272621005403 FtsX-like permease family; Region: FtsX; pfam02687 272621005404 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272621005405 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 272621005406 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272621005407 catalytic core [active] 272621005408 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272621005409 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272621005410 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272621005411 hypothetical protein; Validated; Region: PRK02101 272621005412 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 272621005413 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 272621005414 nucleotide binding site/active site [active] 272621005415 HIT family signature motif; other site 272621005416 catalytic residue [active] 272621005417 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 272621005418 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272621005419 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 272621005420 POT family; Region: PTR2; cl17359 272621005421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272621005422 putative substrate translocation pore; other site 272621005423 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 272621005424 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 272621005425 Zn binding site [ion binding]; other site 272621005426 ERAP1-like C-terminal domain; Region: ERAP1_C; pfam11838 272621005427 Acyltransferase family; Region: Acyl_transf_3; cl19154 272621005428 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 272621005429 putative ADP-ribose binding site [chemical binding]; other site 272621005430 putative active site [active] 272621005431 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272621005432 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 272621005433 Walker A/P-loop; other site 272621005434 ATP binding site [chemical binding]; other site 272621005435 Q-loop/lid; other site 272621005436 ABC transporter signature motif; other site 272621005437 Walker B; other site 272621005438 D-loop; other site 272621005439 H-loop/switch region; other site 272621005440 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272621005441 non-specific DNA binding site [nucleotide binding]; other site 272621005442 salt bridge; other site 272621005443 sequence-specific DNA binding site [nucleotide binding]; other site 272621005444 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272621005445 non-specific DNA binding site [nucleotide binding]; other site 272621005446 salt bridge; other site 272621005447 sequence-specific DNA binding site [nucleotide binding]; other site 272621005448 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272621005449 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272621005450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272621005451 dimer interface [polypeptide binding]; other site 272621005452 conserved gate region; other site 272621005453 putative PBP binding loops; other site 272621005454 ABC-ATPase subunit interface; other site 272621005455 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 272621005456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272621005457 dimer interface [polypeptide binding]; other site 272621005458 conserved gate region; other site 272621005459 putative PBP binding loops; other site 272621005460 ABC-ATPase subunit interface; other site 272621005461 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 272621005462 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 272621005463 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 272621005464 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 272621005465 Walker A/P-loop; other site 272621005466 ATP binding site [chemical binding]; other site 272621005467 Q-loop/lid; other site 272621005468 ABC transporter signature motif; other site 272621005469 Walker B; other site 272621005470 D-loop; other site 272621005471 H-loop/switch region; other site 272621005472 TOBE domain; Region: TOBE_2; pfam08402 272621005473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272621005474 Transposase; Region: HTH_Tnp_1; cl17663 272621005475 HTH-like domain; Region: HTH_21; pfam13276 272621005476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272621005477 Integrase core domain; Region: rve; pfam00665 272621005478 Integrase core domain; Region: rve_2; pfam13333 272621005479 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272621005480 beta-phosphoglucomutase; Region: bPGM; TIGR01990 272621005481 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272621005482 motif II; other site 272621005483 maltose phosphorylase; Provisional; Region: PRK13807 272621005484 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 272621005485 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 272621005486 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 272621005487 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 272621005488 homodimer interface [polypeptide binding]; other site 272621005489 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 272621005490 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 272621005491 active site 272621005492 homodimer interface [polypeptide binding]; other site 272621005493 catalytic site [active] 272621005494 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 272621005495 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 272621005496 Ca binding site [ion binding]; other site 272621005497 active site 272621005498 catalytic site [active] 272621005499 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 272621005500 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272621005501 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272621005502 DNA binding site [nucleotide binding] 272621005503 domain linker motif; other site 272621005504 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272621005505 ligand binding site [chemical binding]; other site 272621005506 dimerization interface [polypeptide binding]; other site 272621005507 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 272621005508 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 272621005509 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 272621005510 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272621005511 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272621005512 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 272621005513 Walker A/P-loop; other site 272621005514 ATP binding site [chemical binding]; other site 272621005515 Q-loop/lid; other site 272621005516 ABC transporter signature motif; other site 272621005517 Walker B; other site 272621005518 D-loop; other site 272621005519 H-loop/switch region; other site 272621005520 glycerol kinase; Provisional; Region: glpK; PRK00047 272621005521 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 272621005522 N- and C-terminal domain interface [polypeptide binding]; other site 272621005523 active site 272621005524 MgATP binding site [chemical binding]; other site 272621005525 catalytic site [active] 272621005526 metal binding site [ion binding]; metal-binding site 272621005527 glycerol binding site [chemical binding]; other site 272621005528 homotetramer interface [polypeptide binding]; other site 272621005529 homodimer interface [polypeptide binding]; other site 272621005530 FBP binding site [chemical binding]; other site 272621005531 protein IIAGlc interface [polypeptide binding]; other site 272621005532 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 272621005533 dimer interface [polypeptide binding]; other site 272621005534 substrate binding site [chemical binding]; other site 272621005535 ATP binding site [chemical binding]; other site 272621005536 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 272621005537 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 272621005538 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 272621005539 Probable transposase; Region: OrfB_IS605; pfam01385 272621005540 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 272621005541 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 272621005542 catalytic triad [active] 272621005543 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272621005544 NlpC/P60 family; Region: NLPC_P60; pfam00877 272621005545 EamA-like transporter family; Region: EamA; pfam00892 272621005546 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 272621005547 EamA-like transporter family; Region: EamA; pfam00892 272621005548 EamA-like transporter family; Region: EamA; pfam00892 272621005549 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 272621005550 EamA-like transporter family; Region: EamA; pfam00892 272621005551 EamA-like transporter family; Region: EamA; pfam00892 272621005552 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 272621005553 EamA-like transporter family; Region: EamA; pfam00892 272621005554 adenylosuccinate lyase; Provisional; Region: PRK07492 272621005555 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 272621005556 tetramer interface [polypeptide binding]; other site 272621005557 active site 272621005558 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 272621005559 GDP-binding site [chemical binding]; other site 272621005560 ACT binding site; other site 272621005561 IMP binding site; other site 272621005562 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 272621005563 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 272621005564 active site 272621005565 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 272621005566 asparagine synthetase A; Reviewed; Region: PRK06462 272621005567 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 272621005568 dimer interface [polypeptide binding]; other site 272621005569 active site 272621005570 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 272621005571 catalytic residues [active] 272621005572 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 272621005573 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272621005574 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272621005575 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272621005576 dimerization interface [polypeptide binding]; other site 272621005577 putative DNA binding site [nucleotide binding]; other site 272621005578 putative Zn2+ binding site [ion binding]; other site 272621005579 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272621005580 active site residue [active] 272621005581 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272621005582 catalytic residues [active] 272621005583 Amino acid permease; Region: AA_permease_2; pfam13520 272621005584 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 272621005585 Peptidase C26; Region: Peptidase_C26; pfam07722 272621005586 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 272621005587 catalytic triad [active] 272621005588 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 272621005589 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 272621005590 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 272621005591 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 272621005592 Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269 272621005593 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 272621005594 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272621005595 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272621005596 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 272621005597 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272621005598 Catalytic site [active] 272621005599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272621005600 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272621005601 Walker A motif; other site 272621005602 ATP binding site [chemical binding]; other site 272621005603 Walker B motif; other site 272621005604 arginine finger; other site 272621005605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272621005606 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272621005607 Walker A motif; other site 272621005608 ATP binding site [chemical binding]; other site 272621005609 Walker B motif; other site 272621005610 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272621005611 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272621005612 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272621005613 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272621005614 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272621005615 Walker A/P-loop; other site 272621005616 ATP binding site [chemical binding]; other site 272621005617 Q-loop/lid; other site 272621005618 ABC transporter signature motif; other site 272621005619 Walker B; other site 272621005620 D-loop; other site 272621005621 H-loop/switch region; other site 272621005622 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272621005623 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272621005624 FtsX-like permease family; Region: FtsX; pfam02687 272621005625 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 272621005626 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272621005627 FtsX-like permease family; Region: FtsX; pfam02687 272621005628 stage V sporulation protein B; Region: spore_V_B; TIGR02900 272621005629 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 272621005630 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 272621005631 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 272621005632 active site 272621005633 Bacterial surface layer protein; Region: SLAP; pfam03217 272621005634 Protein of unknown function (DUF975); Region: DUF975; cl10504 272621005635 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 272621005636 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 272621005637 DltD N-terminal region; Region: DltD_N; pfam04915 272621005638 DltD central region; Region: DltD_M; pfam04918 272621005639 DltD C-terminal region; Region: DltD_C; pfam04914 272621005640 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 272621005641 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 272621005642 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 272621005643 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 272621005644 acyl-activating enzyme (AAE) consensus motif; other site 272621005645 AMP binding site [chemical binding]; other site 272621005646 Uncharacterized conserved protein [Function unknown]; Region: COG3391 272621005647 FOG: CBS domain [General function prediction only]; Region: COG0517 272621005648 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 272621005649 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 272621005650 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272621005651 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272621005652 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 272621005653 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 272621005654 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 272621005655 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272621005656 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272621005657 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272621005658 Walker A/P-loop; other site 272621005659 ATP binding site [chemical binding]; other site 272621005660 Q-loop/lid; other site 272621005661 ABC transporter signature motif; other site 272621005662 Walker B; other site 272621005663 D-loop; other site 272621005664 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272621005665 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272621005666 non-specific DNA binding site [nucleotide binding]; other site 272621005667 salt bridge; other site 272621005668 sequence-specific DNA binding site [nucleotide binding]; other site 272621005669 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 272621005670 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272621005671 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 272621005672 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272621005673 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272621005674 non-specific DNA binding site [nucleotide binding]; other site 272621005675 salt bridge; other site 272621005676 sequence-specific DNA binding site [nucleotide binding]; other site 272621005677 CAAX protease self-immunity; Region: Abi; pfam02517 272621005678 Nucleoporin protein Ndc1-Nup; Region: Ndc1_Nup; pfam09531 272621005679 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272621005680 putative active site [active] 272621005681 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272621005682 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272621005683 Walker A/P-loop; other site 272621005684 ATP binding site [chemical binding]; other site 272621005685 Q-loop/lid; other site 272621005686 ABC transporter signature motif; other site 272621005687 Walker B; other site 272621005688 D-loop; other site 272621005689 H-loop/switch region; other site 272621005690 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272621005691 FtsX-like permease family; Region: FtsX; pfam02687 272621005692 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 272621005693 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 272621005694 ligand binding site [chemical binding]; other site 272621005695 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 272621005696 ligand binding site [chemical binding]; other site 272621005697 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 272621005698 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272621005699 Walker A/P-loop; other site 272621005700 ATP binding site [chemical binding]; other site 272621005701 Q-loop/lid; other site 272621005702 ABC transporter signature motif; other site 272621005703 Walker B; other site 272621005704 D-loop; other site 272621005705 H-loop/switch region; other site 272621005706 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272621005707 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272621005708 TM-ABC transporter signature motif; other site 272621005709 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272621005710 TM-ABC transporter signature motif; other site 272621005711 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272621005712 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 272621005713 active site 272621005714 catalytic tetrad [active] 272621005715 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 272621005716 active site 272621005717 trimer interface [polypeptide binding]; other site 272621005718 allosteric site; other site 272621005719 active site lid [active] 272621005720 hexamer (dimer of trimers) interface [polypeptide binding]; other site 272621005721 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 272621005722 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 272621005723 Substrate-binding site [chemical binding]; other site 272621005724 Substrate specificity [chemical binding]; other site 272621005725 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 272621005726 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 272621005727 Substrate-binding site [chemical binding]; other site 272621005728 Substrate specificity [chemical binding]; other site 272621005729 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272621005730 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272621005731 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 272621005732 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272621005733 Transposase; Region: HTH_Tnp_1; cl17663 272621005734 HTH-like domain; Region: HTH_21; pfam13276 272621005735 Integrase core domain; Region: rve; pfam00665 272621005736 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272621005737 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 272621005738 DNA binding residues [nucleotide binding] 272621005739 dimer interface [polypeptide binding]; other site 272621005740 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 272621005741 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 272621005742 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 272621005743 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272621005744 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272621005745 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272621005746 peptide binding site [polypeptide binding]; other site 272621005747 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272621005748 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272621005749 peptide binding site [polypeptide binding]; other site 272621005750 Penicillinase repressor; Region: Penicillinase_R; cl17580 272621005751 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 272621005752 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 272621005753 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 272621005754 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272621005755 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 272621005756 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 272621005757 Mg++ binding site [ion binding]; other site 272621005758 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272621005759 putative active site [active] 272621005760 Uncharacterized conserved protein [Function unknown]; Region: COG2013 272621005761 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 272621005762 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272621005763 ligand binding site [chemical binding]; other site 272621005764 flexible hinge region; other site 272621005765 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272621005766 putative switch regulator; other site 272621005767 non-specific DNA interactions [nucleotide binding]; other site 272621005768 DNA binding site [nucleotide binding] 272621005769 sequence specific DNA binding site [nucleotide binding]; other site 272621005770 putative cAMP binding site [chemical binding]; other site 272621005771 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 272621005772 Cl- selectivity filter; other site 272621005773 Cl- binding residues [ion binding]; other site 272621005774 pore gating glutamate residue; other site 272621005775 dimer interface [polypeptide binding]; other site 272621005776 H+/Cl- coupling transport residue; other site 272621005777 TrkA-C domain; Region: TrkA_C; pfam02080 272621005778 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 272621005779 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 272621005780 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 272621005781 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 272621005782 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 272621005783 PYR/PP interface [polypeptide binding]; other site 272621005784 dimer interface [polypeptide binding]; other site 272621005785 TPP binding site [chemical binding]; other site 272621005786 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272621005787 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 272621005788 TPP-binding site [chemical binding]; other site 272621005789 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 272621005790 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 272621005791 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 272621005792 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 272621005793 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 272621005794 trmE is a tRNA modification GTPase; Region: trmE; cd04164 272621005795 G1 box; other site 272621005796 GTP/Mg2+ binding site [chemical binding]; other site 272621005797 Switch I region; other site 272621005798 G2 box; other site 272621005799 Switch II region; other site 272621005800 G3 box; other site 272621005801 G4 box; other site 272621005802 G5 box; other site 272621005803 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 272621005804 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 272621005805 ribonuclease P; Reviewed; Region: rnpA; PRK00499 272621005806 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399