-- dump date 20140619_122418 -- class Genbank::misc_feature -- table misc_feature_note -- id note 695562000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 695562000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 695562000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 695562000004 Walker A motif; other site 695562000005 ATP binding site [chemical binding]; other site 695562000006 Walker B motif; other site 695562000007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 695562000008 arginine finger; other site 695562000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 695562000010 DnaA box-binding interface [nucleotide binding]; other site 695562000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 695562000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 695562000013 putative DNA binding surface [nucleotide binding]; other site 695562000014 dimer interface [polypeptide binding]; other site 695562000015 beta-clamp/clamp loader binding surface; other site 695562000016 beta-clamp/translesion DNA polymerase binding surface; other site 695562000017 S4 domain; Region: S4_2; pfam13275 695562000018 recombination protein F; Reviewed; Region: recF; PRK00064 695562000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 695562000020 Walker A/P-loop; other site 695562000021 ATP binding site [chemical binding]; other site 695562000022 Q-loop/lid; other site 695562000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 695562000024 ABC transporter signature motif; other site 695562000025 Walker B; other site 695562000026 D-loop; other site 695562000027 H-loop/switch region; other site 695562000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 695562000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 695562000030 Mg2+ binding site [ion binding]; other site 695562000031 G-X-G motif; other site 695562000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 695562000033 anchoring element; other site 695562000034 dimer interface [polypeptide binding]; other site 695562000035 ATP binding site [chemical binding]; other site 695562000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 695562000037 active site 695562000038 putative metal-binding site [ion binding]; other site 695562000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 695562000040 DNA gyrase subunit A; Validated; Region: PRK05560 695562000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 695562000042 CAP-like domain; other site 695562000043 active site 695562000044 primary dimer interface [polypeptide binding]; other site 695562000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 695562000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 695562000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 695562000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 695562000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 695562000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 695562000051 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 695562000052 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 695562000053 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 695562000054 dimer interface [polypeptide binding]; other site 695562000055 ssDNA binding site [nucleotide binding]; other site 695562000056 tetramer (dimer of dimers) interface [polypeptide binding]; other site 695562000057 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 695562000058 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 695562000059 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 695562000060 DHH family; Region: DHH; pfam01368 695562000061 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 695562000062 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 695562000063 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 695562000064 replicative DNA helicase; Region: DnaB; TIGR00665 695562000065 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 695562000066 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 695562000067 Walker A motif; other site 695562000068 ATP binding site [chemical binding]; other site 695562000069 Walker B motif; other site 695562000070 DNA binding loops [nucleotide binding] 695562000071 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 695562000072 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 695562000073 substrate binding pocket [chemical binding]; other site 695562000074 membrane-bound complex binding site; other site 695562000075 hinge residues; other site 695562000076 EDD domain protein, DegV family; Region: DegV; TIGR00762 695562000077 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 695562000078 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 695562000079 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 695562000080 nucleotide binding site [chemical binding]; other site 695562000081 Predicted membrane protein [Function unknown]; Region: COG2261 695562000082 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 695562000083 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 695562000084 MgtC family; Region: MgtC; pfam02308 695562000085 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 695562000086 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 695562000087 maltose O-acetyltransferase; Provisional; Region: PRK10092 695562000088 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 695562000089 active site 695562000090 substrate binding site [chemical binding]; other site 695562000091 trimer interface [polypeptide binding]; other site 695562000092 CoA binding site [chemical binding]; other site 695562000093 Restriction endonuclease; Region: Mrr_cat; pfam04471 695562000094 Peptidase family C69; Region: Peptidase_C69; pfam03577 695562000095 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 695562000096 Predicted membrane protein [Function unknown]; Region: COG4905 695562000097 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 695562000098 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 695562000099 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 695562000100 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 695562000101 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 695562000102 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 695562000103 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 695562000104 Domain of unknown function DUF20; Region: UPF0118; pfam01594 695562000105 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 695562000106 catalytic triad [active] 695562000107 oxyanion hole [active] 695562000108 active site 695562000109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 695562000110 putative substrate translocation pore; other site 695562000111 Major Facilitator Superfamily; Region: MFS_1; pfam07690 695562000112 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 695562000113 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 695562000114 Integrase core domain; Region: rve; pfam00665 695562000115 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 695562000116 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 695562000117 Walker A/P-loop; other site 695562000118 ATP binding site [chemical binding]; other site 695562000119 Q-loop/lid; other site 695562000120 ABC transporter signature motif; other site 695562000121 Walker B; other site 695562000122 D-loop; other site 695562000123 H-loop/switch region; other site 695562000124 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 695562000125 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 695562000126 TM-ABC transporter signature motif; other site 695562000127 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 695562000128 zinc binding site [ion binding]; other site 695562000129 putative ligand binding site [chemical binding]; other site 695562000130 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 695562000131 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 695562000132 motif II; other site 695562000133 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 695562000134 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 695562000135 G1 box; other site 695562000136 putative GEF interaction site [polypeptide binding]; other site 695562000137 GTP/Mg2+ binding site [chemical binding]; other site 695562000138 Switch I region; other site 695562000139 G2 box; other site 695562000140 G3 box; other site 695562000141 Switch II region; other site 695562000142 G4 box; other site 695562000143 G5 box; other site 695562000144 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 695562000145 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 695562000146 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 695562000147 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 695562000148 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 695562000149 active site 695562000150 motif I; other site 695562000151 motif II; other site 695562000152 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 695562000153 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 695562000154 putative catalytic site [active] 695562000155 putative metal binding site [ion binding]; other site 695562000156 putative phosphate binding site [ion binding]; other site 695562000157 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 695562000158 catalytic core [active] 695562000159 D-lactate dehydrogenase; Validated; Region: PRK08605 695562000160 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 695562000161 homodimer interface [polypeptide binding]; other site 695562000162 ligand binding site [chemical binding]; other site 695562000163 NAD binding site [chemical binding]; other site 695562000164 catalytic site [active] 695562000165 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 695562000166 active site 695562000167 putative catalytic site [active] 695562000168 DNA binding site [nucleotide binding] 695562000169 putative phosphate binding site [ion binding]; other site 695562000170 metal binding site A [ion binding]; metal-binding site 695562000171 AP binding site [nucleotide binding]; other site 695562000172 metal binding site B [ion binding]; metal-binding site 695562000173 potential frameshift: common BLAST hit: gi|295691917|ref|YP_003600527.1| glutamate/gamma-aminobutyrate antiporter 695562000174 potential frameshift: common BLAST hit: gi|58336407|ref|YP_192992.1| glutamategamma-aminobutyrate antiporter 695562000175 potential frameshift: common BLAST hit: gi|295691917|ref|YP_003600527.1| glutamate/gamma-aminobutyrate antiporter 695562000176 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 695562000177 PLD-like domain; Region: PLDc_2; pfam13091 695562000178 putative homodimer interface [polypeptide binding]; other site 695562000179 putative active site [active] 695562000180 catalytic site [active] 695562000181 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 695562000182 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 695562000183 ATP binding site [chemical binding]; other site 695562000184 putative Mg++ binding site [ion binding]; other site 695562000185 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 695562000186 nucleotide binding region [chemical binding]; other site 695562000187 ATP-binding site [chemical binding]; other site 695562000188 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 695562000189 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 695562000190 Beta-lactamase; Region: Beta-lactamase; pfam00144 695562000191 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 695562000192 AAA ATPase domain; Region: AAA_16; pfam13191 695562000193 Uncharacterized conserved protein [Function unknown]; Region: COG3410 695562000194 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 695562000195 active site 695562000196 catalytic residues [active] 695562000197 metal binding site [ion binding]; metal-binding site 695562000198 Transcriptional regulator [Transcription]; Region: LysR; COG0583 695562000199 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 695562000200 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 695562000201 dimerization interface [polypeptide binding]; other site 695562000202 FMN-binding domain; Region: FMN_bind; pfam04205 695562000203 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 695562000204 L-aspartate oxidase; Provisional; Region: PRK06175 695562000205 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 695562000206 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 695562000207 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 695562000208 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 695562000209 putative acyl-acceptor binding pocket; other site 695562000210 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 695562000211 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 695562000212 Ligand binding site; other site 695562000213 metal-binding site 695562000214 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 695562000215 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 695562000216 Ligand binding site; other site 695562000217 metal-binding site 695562000218 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 695562000219 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 695562000220 active site 695562000221 Helix-turn-helix domain; Region: HTH_19; pfam12844 695562000222 non-specific DNA binding site [nucleotide binding]; other site 695562000223 salt bridge; other site 695562000224 sequence-specific DNA binding site [nucleotide binding]; other site 695562000225 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 695562000226 Helix-turn-helix domain; Region: HTH_38; pfam13936 695562000227 Integrase core domain; Region: rve; pfam00665 695562000228 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 695562000229 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 695562000230 non-specific DNA binding site [nucleotide binding]; other site 695562000231 salt bridge; other site 695562000232 sequence-specific DNA binding site [nucleotide binding]; other site 695562000233 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 695562000234 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 695562000235 putative acyl-acceptor binding pocket; other site 695562000236 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 695562000237 Probable transposase; Region: OrfB_IS605; pfam01385 695562000238 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 695562000239 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 695562000240 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 695562000241 potential frameshift: common BLAST hit: gi|315037313|ref|YP_004030881.1| prophage repressor 695562000242 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 695562000243 non-specific DNA binding site [nucleotide binding]; other site 695562000244 salt bridge; other site 695562000245 sequence-specific DNA binding site [nucleotide binding]; other site 695562000246 Bacterial surface layer protein; Region: SLAP; pfam03217 695562000247 Peptidase family M48; Region: Peptidase_M48; cl12018 695562000248 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 695562000249 non-specific DNA binding site [nucleotide binding]; other site 695562000250 salt bridge; other site 695562000251 sequence-specific DNA binding site [nucleotide binding]; other site 695562000252 Bacterial surface layer protein; Region: SLAP; pfam03217 695562000253 Bacterial surface layer protein; Region: SLAP; pfam03217 695562000254 Bacterial surface layer protein; Region: SLAP; pfam03217 695562000255 potential protein location (hypothetical protein LAB52_00460 [Lactobacillus amylovorus GRL 1118]) that overlaps RNA (tRNA-K) 695562000256 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 695562000257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 695562000258 active site 695562000259 phosphorylation site [posttranslational modification] 695562000260 intermolecular recognition site; other site 695562000261 dimerization interface [polypeptide binding]; other site 695562000262 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 695562000263 DNA binding site [nucleotide binding] 695562000264 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 695562000265 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 695562000266 dimerization interface [polypeptide binding]; other site 695562000267 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 695562000268 putative active site [active] 695562000269 heme pocket [chemical binding]; other site 695562000270 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 695562000271 dimer interface [polypeptide binding]; other site 695562000272 phosphorylation site [posttranslational modification] 695562000273 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 695562000274 ATP binding site [chemical binding]; other site 695562000275 Mg2+ binding site [ion binding]; other site 695562000276 G-X-G motif; other site 695562000277 YycH protein; Region: YycH; pfam07435 695562000278 YycH protein; Region: YycI; pfam09648 695562000279 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 695562000280 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 695562000281 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 695562000282 protein binding site [polypeptide binding]; other site 695562000283 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 695562000284 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 695562000285 non-specific DNA binding site [nucleotide binding]; other site 695562000286 salt bridge; other site 695562000287 sequence-specific DNA binding site [nucleotide binding]; other site 695562000288 MyTH4 domain; Region: MyTH4; cl02480 695562000289 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 695562000290 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 695562000291 active site 695562000292 substrate binding site [chemical binding]; other site 695562000293 trimer interface [polypeptide binding]; other site 695562000294 CoA binding site [chemical binding]; other site 695562000295 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 695562000296 Cobalt transport protein; Region: CbiQ; cl00463 695562000297 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 695562000298 Walker A/P-loop; other site 695562000299 ATP binding site [chemical binding]; other site 695562000300 ABC transporter; Region: ABC_tran; pfam00005 695562000301 Q-loop/lid; other site 695562000302 ABC transporter signature motif; other site 695562000303 Walker B; other site 695562000304 D-loop; other site 695562000305 H-loop/switch region; other site 695562000306 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 695562000307 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 695562000308 Walker A/P-loop; other site 695562000309 ATP binding site [chemical binding]; other site 695562000310 Q-loop/lid; other site 695562000311 ABC transporter signature motif; other site 695562000312 Walker B; other site 695562000313 D-loop; other site 695562000314 H-loop/switch region; other site 695562000315 Helix-turn-helix domain; Region: HTH_18; pfam12833 695562000316 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 695562000317 heat shock protein HtpX; Provisional; Region: PRK04897 695562000318 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 695562000319 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 695562000320 transmembrane helices; other site 695562000321 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 695562000322 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 695562000323 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 695562000324 putative active site [active] 695562000325 catalytic site [active] 695562000326 putative metal binding site [ion binding]; other site 695562000327 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 695562000328 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 695562000329 DXD motif; other site 695562000330 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 695562000331 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 695562000332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 695562000333 putative substrate translocation pore; other site 695562000334 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 695562000335 Zn2+ binding site [ion binding]; other site 695562000336 Mg2+ binding site [ion binding]; other site 695562000337 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 695562000338 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 695562000339 active site 695562000340 Protein of unknown function (DUF805); Region: DUF805; pfam05656 695562000341 Protein of unknown function (DUF805); Region: DUF805; pfam05656 695562000342 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 695562000343 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 695562000344 Walker A/P-loop; other site 695562000345 ATP binding site [chemical binding]; other site 695562000346 Q-loop/lid; other site 695562000347 ABC transporter signature motif; other site 695562000348 Walker B; other site 695562000349 D-loop; other site 695562000350 H-loop/switch region; other site 695562000351 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 695562000352 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 695562000353 substrate binding pocket [chemical binding]; other site 695562000354 membrane-bound complex binding site; other site 695562000355 hinge residues; other site 695562000356 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 695562000357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 695562000358 dimer interface [polypeptide binding]; other site 695562000359 conserved gate region; other site 695562000360 putative PBP binding loops; other site 695562000361 ABC-ATPase subunit interface; other site 695562000362 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 695562000363 active site 695562000364 DNA binding site [nucleotide binding] 695562000365 Uncharacterized conserved protein [Function unknown]; Region: COG3189 695562000366 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 695562000367 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 695562000368 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 695562000369 DNA binding site [nucleotide binding] 695562000370 active site 695562000371 NAD-dependent deacetylase; Provisional; Region: PRK00481 695562000372 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 695562000373 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 695562000374 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 695562000375 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 695562000376 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 695562000377 putative active site [active] 695562000378 catalytic site [active] 695562000379 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 695562000380 putative active site [active] 695562000381 catalytic site [active] 695562000382 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 695562000383 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 695562000384 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 695562000385 RNA/DNA hybrid binding site [nucleotide binding]; other site 695562000386 active site 695562000387 Predicted secreted protein [Function unknown]; Region: COG4086 695562000388 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 695562000389 putative glycosyl transferase; Provisional; Region: PRK10073 695562000390 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 695562000391 active site 695562000392 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 695562000393 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 695562000394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 695562000395 NADH(P)-binding; Region: NAD_binding_10; pfam13460 695562000396 NAD(P) binding site [chemical binding]; other site 695562000397 active site 695562000398 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 695562000399 Divergent AAA domain; Region: AAA_4; pfam04326 695562000400 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 695562000401 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 695562000402 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 695562000403 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 695562000404 active site 695562000405 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 695562000406 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 695562000407 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 695562000408 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 695562000409 substrate binding pocket [chemical binding]; other site 695562000410 membrane-bound complex binding site; other site 695562000411 hinge residues; other site 695562000412 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 695562000413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 695562000414 dimer interface [polypeptide binding]; other site 695562000415 conserved gate region; other site 695562000416 putative PBP binding loops; other site 695562000417 ABC-ATPase subunit interface; other site 695562000418 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 695562000419 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 695562000420 Walker A/P-loop; other site 695562000421 ATP binding site [chemical binding]; other site 695562000422 Q-loop/lid; other site 695562000423 ABC transporter signature motif; other site 695562000424 Walker B; other site 695562000425 D-loop; other site 695562000426 H-loop/switch region; other site 695562000427 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 695562000428 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 695562000429 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 695562000430 ATP-grasp domain; Region: ATP-grasp_4; cl17255 695562000431 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 695562000432 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 695562000433 DNA binding residues [nucleotide binding] 695562000434 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 695562000435 YibE/F-like protein; Region: YibE_F; pfam07907 695562000436 YibE/F-like protein; Region: YibE_F; pfam07907 695562000437 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 695562000438 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 695562000439 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 695562000440 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 695562000441 active site 695562000442 catalytic site [active] 695562000443 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 695562000444 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 695562000445 Interdomain contacts; other site 695562000446 Cytokine receptor motif; other site 695562000447 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 695562000448 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 695562000449 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 695562000450 active site 695562000451 dimer interface [polypeptide binding]; other site 695562000452 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 695562000453 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 695562000454 active site 695562000455 phosphorylation site [posttranslational modification] 695562000456 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 695562000457 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 695562000458 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 695562000459 Ligand Binding Site [chemical binding]; other site 695562000460 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 695562000461 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 695562000462 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 695562000463 membrane-bound complex binding site; other site 695562000464 hinge residues; other site 695562000465 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 695562000466 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 695562000467 Walker A/P-loop; other site 695562000468 ATP binding site [chemical binding]; other site 695562000469 Q-loop/lid; other site 695562000470 ABC transporter signature motif; other site 695562000471 Walker B; other site 695562000472 D-loop; other site 695562000473 H-loop/switch region; other site 695562000474 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 695562000475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 695562000476 dimer interface [polypeptide binding]; other site 695562000477 conserved gate region; other site 695562000478 putative PBP binding loops; other site 695562000479 ABC-ATPase subunit interface; other site 695562000480 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 695562000481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 695562000482 dimer interface [polypeptide binding]; other site 695562000483 conserved gate region; other site 695562000484 putative PBP binding loops; other site 695562000485 ABC-ATPase subunit interface; other site 695562000486 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 695562000487 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 695562000488 active site 695562000489 metal binding site [ion binding]; metal-binding site 695562000490 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 695562000491 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 695562000492 active site 695562000493 dimer interface [polypeptide binding]; other site 695562000494 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 695562000495 Ligand Binding Site [chemical binding]; other site 695562000496 Molecular Tunnel; other site 695562000497 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 695562000498 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 695562000499 ATP-grasp domain; Region: ATP-grasp_4; cl17255 695562000500 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 695562000501 ATP cone domain; Region: ATP-cone; pfam03477 695562000502 Class III ribonucleotide reductase; Region: RNR_III; cd01675 695562000503 effector binding site; other site 695562000504 active site 695562000505 Zn binding site [ion binding]; other site 695562000506 glycine loop; other site 695562000507 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 695562000508 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 695562000509 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 695562000510 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 695562000511 Uncharacterized conserved protein [Function unknown]; Region: COG2461 695562000512 Family of unknown function (DUF438); Region: DUF438; pfam04282 695562000513 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 695562000514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 695562000515 Major Facilitator Superfamily; Region: MFS_1; pfam07690 695562000516 putative substrate translocation pore; other site 695562000517 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 695562000518 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 695562000519 active site 695562000520 Zn binding site [ion binding]; other site 695562000521 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 695562000522 K+ potassium transporter; Region: K_trans; pfam02705 695562000523 RelB antitoxin; Region: RelB; cl01171 695562000524 RloB-like protein; Region: RloB; pfam13707 695562000525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 695562000526 AAA domain; Region: AAA_21; pfam13304 695562000527 Walker A/P-loop; other site 695562000528 ATP binding site [chemical binding]; other site 695562000529 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 695562000530 Bacterial surface layer protein; Region: SLAP; pfam03217 695562000531 potential frameshift: common BLAST hit: gi|295693304|ref|YP_003601914.1| transposase 695562000532 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 695562000533 Bacterial surface layer protein; Region: SLAP; pfam03217 695562000534 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 695562000535 amidase catalytic site [active] 695562000536 Zn binding residues [ion binding]; other site 695562000537 substrate binding site [chemical binding]; other site 695562000538 Bacterial surface layer protein; Region: SLAP; pfam03217 695562000539 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 695562000540 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 695562000541 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 695562000542 TrkA-N domain; Region: TrkA_N; pfam02254 695562000543 TrkA-C domain; Region: TrkA_C; pfam02080 695562000544 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 695562000545 AAA domain; Region: AAA_14; pfam13173 695562000546 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 695562000547 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 695562000548 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 695562000549 catalytic core [active] 695562000550 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 695562000551 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 695562000552 putative substrate binding pocket [chemical binding]; other site 695562000553 AC domain interface; other site 695562000554 catalytic triad [active] 695562000555 AB domain interface; other site 695562000556 interchain disulfide; other site 695562000557 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 695562000558 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 695562000559 membrane protein; Provisional; Region: PRK14411 695562000560 Sulfatase; Region: Sulfatase; cl17466 695562000561 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 695562000562 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 695562000563 active site 695562000564 HIGH motif; other site 695562000565 dimer interface [polypeptide binding]; other site 695562000566 KMSKS motif; other site 695562000567 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 695562000568 RNA binding surface [nucleotide binding]; other site 695562000569 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 695562000570 trimer interface [polypeptide binding]; other site 695562000571 active site 695562000572 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 695562000573 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 695562000574 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 695562000575 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 695562000576 peptide binding site [polypeptide binding]; other site 695562000577 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 695562000578 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 695562000579 peptide binding site [polypeptide binding]; other site 695562000580 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 695562000581 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 695562000582 active site 695562000583 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 695562000584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 695562000585 dimer interface [polypeptide binding]; other site 695562000586 conserved gate region; other site 695562000587 putative PBP binding loops; other site 695562000588 ABC-ATPase subunit interface; other site 695562000589 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 695562000590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 695562000591 dimer interface [polypeptide binding]; other site 695562000592 conserved gate region; other site 695562000593 putative PBP binding loops; other site 695562000594 ABC-ATPase subunit interface; other site 695562000595 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 695562000596 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 695562000597 Walker A/P-loop; other site 695562000598 ATP binding site [chemical binding]; other site 695562000599 Q-loop/lid; other site 695562000600 ABC transporter signature motif; other site 695562000601 Walker B; other site 695562000602 D-loop; other site 695562000603 H-loop/switch region; other site 695562000604 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 695562000605 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 695562000606 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 695562000607 Walker A/P-loop; other site 695562000608 ATP binding site [chemical binding]; other site 695562000609 Q-loop/lid; other site 695562000610 ABC transporter signature motif; other site 695562000611 Walker B; other site 695562000612 D-loop; other site 695562000613 H-loop/switch region; other site 695562000614 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 695562000615 Transposase IS200 like; Region: Y1_Tnp; pfam01797 695562000616 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 695562000617 Probable transposase; Region: OrfB_IS605; pfam01385 695562000618 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 695562000619 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 695562000620 trimer interface [polypeptide binding]; other site 695562000621 active site 695562000622 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 695562000623 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 695562000624 putative dimer interface [polypeptide binding]; other site 695562000625 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 695562000626 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 695562000627 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 695562000628 CAAX protease self-immunity; Region: Abi; pfam02517 695562000629 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 695562000630 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 695562000631 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 695562000632 active site 695562000633 HIGH motif; other site 695562000634 dimer interface [polypeptide binding]; other site 695562000635 KMSKS motif; other site 695562000636 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 695562000637 catalytic motif [active] 695562000638 Zn binding site [ion binding]; other site 695562000639 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 695562000640 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 695562000641 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 695562000642 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 695562000643 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 695562000644 Soluble P-type ATPase [General function prediction only]; Region: COG4087 695562000645 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 695562000646 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 695562000647 active site 695562000648 HIGH motif; other site 695562000649 KMSKS motif; other site 695562000650 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 695562000651 tRNA binding surface [nucleotide binding]; other site 695562000652 anticodon binding site; other site 695562000653 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 695562000654 dimer interface [polypeptide binding]; other site 695562000655 putative tRNA-binding site [nucleotide binding]; other site 695562000656 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 695562000657 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 695562000658 active site 695562000659 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 695562000660 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 695562000661 putative active site [active] 695562000662 putative metal binding site [ion binding]; other site 695562000663 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 695562000664 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 695562000665 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 695562000666 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 695562000667 pur operon repressor; Provisional; Region: PRK09213 695562000668 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 695562000669 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 695562000670 active site 695562000671 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 695562000672 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 695562000673 Substrate binding site; other site 695562000674 Mg++ binding site; other site 695562000675 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 695562000676 active site 695562000677 substrate binding site [chemical binding]; other site 695562000678 CoA binding site [chemical binding]; other site 695562000679 Bacterial surface layer protein; Region: SLAP; pfam03217 695562000680 Bacterial surface layer protein; Region: SLAP; pfam03217 695562000681 Bacterial surface layer protein; Region: SLAP; pfam03217 695562000682 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 695562000683 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 695562000684 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 695562000685 active site 695562000686 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 695562000687 beta-galactosidase; Region: BGL; TIGR03356 695562000688 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 695562000689 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 695562000690 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 695562000691 putative active site [active] 695562000692 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 695562000693 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 695562000694 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 695562000695 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 695562000696 nucleotide binding site [chemical binding]; other site 695562000697 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 695562000698 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 695562000699 Zn2+ binding site [ion binding]; other site 695562000700 Mg2+ binding site [ion binding]; other site 695562000701 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 695562000702 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 695562000703 CTP synthetase; Validated; Region: pyrG; PRK05380 695562000704 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 695562000705 Catalytic site [active] 695562000706 active site 695562000707 UTP binding site [chemical binding]; other site 695562000708 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 695562000709 active site 695562000710 putative oxyanion hole; other site 695562000711 catalytic triad [active] 695562000712 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 695562000713 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 695562000714 hinge; other site 695562000715 active site 695562000716 Peptidase family C69; Region: Peptidase_C69; pfam03577 695562000717 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 695562000718 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 695562000719 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 695562000720 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 695562000721 xanthine permease; Region: pbuX; TIGR03173 695562000722 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 695562000723 active site 695562000724 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 695562000725 sequence-specific DNA binding site [nucleotide binding]; other site 695562000726 salt bridge; other site 695562000727 GMP synthase; Reviewed; Region: guaA; PRK00074 695562000728 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 695562000729 AMP/PPi binding site [chemical binding]; other site 695562000730 candidate oxyanion hole; other site 695562000731 catalytic triad [active] 695562000732 potential glutamine specificity residues [chemical binding]; other site 695562000733 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 695562000734 ATP Binding subdomain [chemical binding]; other site 695562000735 Ligand Binding sites [chemical binding]; other site 695562000736 Dimerization subdomain; other site 695562000737 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 695562000738 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 695562000739 DNA binding site [nucleotide binding] 695562000740 active site 695562000741 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 695562000742 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 695562000743 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 695562000744 Coenzyme A binding pocket [chemical binding]; other site 695562000745 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 695562000746 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 695562000747 dimer interface [polypeptide binding]; other site 695562000748 active site 695562000749 glycine-pyridoxal phosphate binding site [chemical binding]; other site 695562000750 folate binding site [chemical binding]; other site 695562000751 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 695562000752 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 695562000753 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 695562000754 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 695562000755 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 695562000756 Ca binding site [ion binding]; other site 695562000757 active site 695562000758 catalytic site [active] 695562000759 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 695562000760 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 695562000761 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 695562000762 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 695562000763 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 695562000764 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 695562000765 DEAD-like helicases superfamily; Region: DEXDc; smart00487 695562000766 ATP binding site [chemical binding]; other site 695562000767 Mg++ binding site [ion binding]; other site 695562000768 motif III; other site 695562000769 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 695562000770 nucleotide binding region [chemical binding]; other site 695562000771 ATP-binding site [chemical binding]; other site 695562000772 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 695562000773 alanine racemase; Reviewed; Region: alr; PRK00053 695562000774 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 695562000775 active site 695562000776 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 695562000777 dimer interface [polypeptide binding]; other site 695562000778 substrate binding site [chemical binding]; other site 695562000779 catalytic residues [active] 695562000780 FOG: CBS domain [General function prediction only]; Region: COG0517 695562000781 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 695562000782 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 695562000783 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 695562000784 tetramer (dimer of dimers) interface [polypeptide binding]; other site 695562000785 NAD binding site [chemical binding]; other site 695562000786 dimer interface [polypeptide binding]; other site 695562000787 substrate binding site [chemical binding]; other site 695562000788 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 695562000789 putative active site [active] 695562000790 catalytic residue [active] 695562000791 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 695562000792 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 695562000793 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 695562000794 ATP binding site [chemical binding]; other site 695562000795 putative Mg++ binding site [ion binding]; other site 695562000796 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 695562000797 nucleotide binding region [chemical binding]; other site 695562000798 ATP-binding site [chemical binding]; other site 695562000799 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 695562000800 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 695562000801 RNA binding surface [nucleotide binding]; other site 695562000802 Septum formation initiator; Region: DivIC; pfam04977 695562000803 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 695562000804 RNA binding site [nucleotide binding]; other site 695562000805 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 695562000806 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 695562000807 Ligand Binding Site [chemical binding]; other site 695562000808 FtsH Extracellular; Region: FtsH_ext; pfam06480 695562000809 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 695562000810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 695562000811 Walker A motif; other site 695562000812 ATP binding site [chemical binding]; other site 695562000813 Walker B motif; other site 695562000814 arginine finger; other site 695562000815 Peptidase family M41; Region: Peptidase_M41; pfam01434 695562000816 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 695562000817 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 695562000818 dimerization interface [polypeptide binding]; other site 695562000819 domain crossover interface; other site 695562000820 redox-dependent activation switch; other site 695562000821 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 695562000822 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 695562000823 FMN binding site [chemical binding]; other site 695562000824 active site 695562000825 catalytic residues [active] 695562000826 substrate binding site [chemical binding]; other site 695562000827 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 695562000828 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 695562000829 dimer interface [polypeptide binding]; other site 695562000830 putative anticodon binding site; other site 695562000831 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 695562000832 motif 1; other site 695562000833 active site 695562000834 motif 2; other site 695562000835 motif 3; other site 695562000836 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 695562000837 Coenzyme A binding pocket [chemical binding]; other site 695562000838 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 695562000839 GAF domain; Region: GAF_2; pfam13185 695562000840 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 695562000841 Clp amino terminal domain; Region: Clp_N; pfam02861 695562000842 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 695562000843 Walker A motif; other site 695562000844 ATP binding site [chemical binding]; other site 695562000845 Walker B motif; other site 695562000846 arginine finger; other site 695562000847 UvrB/uvrC motif; Region: UVR; pfam02151 695562000848 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 695562000849 Walker A motif; other site 695562000850 ATP binding site [chemical binding]; other site 695562000851 Walker B motif; other site 695562000852 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 695562000853 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 695562000854 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 695562000855 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 695562000856 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 695562000857 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 695562000858 RPB1 interaction site [polypeptide binding]; other site 695562000859 RPB10 interaction site [polypeptide binding]; other site 695562000860 RPB11 interaction site [polypeptide binding]; other site 695562000861 RPB3 interaction site [polypeptide binding]; other site 695562000862 RPB12 interaction site [polypeptide binding]; other site 695562000863 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 695562000864 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 695562000865 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 695562000866 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 695562000867 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 695562000868 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 695562000869 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 695562000870 G-loop; other site 695562000871 DNA binding site [nucleotide binding] 695562000872 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 695562000873 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 695562000874 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 695562000875 S17 interaction site [polypeptide binding]; other site 695562000876 S8 interaction site; other site 695562000877 16S rRNA interaction site [nucleotide binding]; other site 695562000878 streptomycin interaction site [chemical binding]; other site 695562000879 23S rRNA interaction site [nucleotide binding]; other site 695562000880 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 695562000881 30S ribosomal protein S7; Validated; Region: PRK05302 695562000882 elongation factor G; Reviewed; Region: PRK12739 695562000883 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 695562000884 G1 box; other site 695562000885 putative GEF interaction site [polypeptide binding]; other site 695562000886 GTP/Mg2+ binding site [chemical binding]; other site 695562000887 Switch I region; other site 695562000888 G2 box; other site 695562000889 G3 box; other site 695562000890 Switch II region; other site 695562000891 G4 box; other site 695562000892 G5 box; other site 695562000893 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 695562000894 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 695562000895 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 695562000896 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 695562000897 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 695562000898 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 695562000899 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 695562000900 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 695562000901 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 695562000902 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 695562000903 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 695562000904 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 695562000905 putative translocon binding site; other site 695562000906 protein-rRNA interface [nucleotide binding]; other site 695562000907 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 695562000908 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 695562000909 G-X-X-G motif; other site 695562000910 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 695562000911 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 695562000912 23S rRNA interface [nucleotide binding]; other site 695562000913 5S rRNA interface [nucleotide binding]; other site 695562000914 putative antibiotic binding site [chemical binding]; other site 695562000915 L25 interface [polypeptide binding]; other site 695562000916 L27 interface [polypeptide binding]; other site 695562000917 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 695562000918 23S rRNA interface [nucleotide binding]; other site 695562000919 putative translocon interaction site; other site 695562000920 signal recognition particle (SRP54) interaction site; other site 695562000921 L23 interface [polypeptide binding]; other site 695562000922 trigger factor interaction site; other site 695562000923 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 695562000924 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 695562000925 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 695562000926 RNA binding site [nucleotide binding]; other site 695562000927 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 695562000928 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 695562000929 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 695562000930 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 695562000931 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 695562000932 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 695562000933 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 695562000934 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 695562000935 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 695562000936 5S rRNA interface [nucleotide binding]; other site 695562000937 23S rRNA interface [nucleotide binding]; other site 695562000938 L5 interface [polypeptide binding]; other site 695562000939 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 695562000940 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 695562000941 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 695562000942 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 695562000943 23S rRNA binding site [nucleotide binding]; other site 695562000944 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 695562000945 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 695562000946 SecY translocase; Region: SecY; pfam00344 695562000947 adenylate kinase; Reviewed; Region: adk; PRK00279 695562000948 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 695562000949 AMP-binding site [chemical binding]; other site 695562000950 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 695562000951 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 695562000952 rRNA binding site [nucleotide binding]; other site 695562000953 predicted 30S ribosome binding site; other site 695562000954 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 695562000955 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 695562000956 30S ribosomal protein S13; Region: bact_S13; TIGR03631 695562000957 30S ribosomal protein S11; Validated; Region: PRK05309 695562000958 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 695562000959 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 695562000960 alphaNTD homodimer interface [polypeptide binding]; other site 695562000961 alphaNTD - beta interaction site [polypeptide binding]; other site 695562000962 alphaNTD - beta' interaction site [polypeptide binding]; other site 695562000963 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 695562000964 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 695562000965 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13640 695562000966 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 695562000967 Walker A/P-loop; other site 695562000968 ATP binding site [chemical binding]; other site 695562000969 Q-loop/lid; other site 695562000970 ABC transporter signature motif; other site 695562000971 Walker B; other site 695562000972 D-loop; other site 695562000973 H-loop/switch region; other site 695562000974 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13641 695562000975 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 695562000976 Walker A/P-loop; other site 695562000977 ATP binding site [chemical binding]; other site 695562000978 Q-loop/lid; other site 695562000979 ABC transporter signature motif; other site 695562000980 Walker B; other site 695562000981 D-loop; other site 695562000982 H-loop/switch region; other site 695562000983 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 695562000984 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 695562000985 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 695562000986 dimerization interface 3.5A [polypeptide binding]; other site 695562000987 active site 695562000988 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 695562000989 23S rRNA interface [nucleotide binding]; other site 695562000990 L3 interface [polypeptide binding]; other site 695562000991 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 695562000992 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 695562000993 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 695562000994 Walker A/P-loop; other site 695562000995 ATP binding site [chemical binding]; other site 695562000996 Q-loop/lid; other site 695562000997 ABC transporter signature motif; other site 695562000998 Walker B; other site 695562000999 D-loop; other site 695562001000 H-loop/switch region; other site 695562001001 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 695562001002 DJ-1 family protein; Region: not_thiJ; TIGR01383 695562001003 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 695562001004 conserved cys residue [active] 695562001005 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 695562001006 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 695562001007 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 695562001008 catalytic core [active] 695562001009 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 695562001010 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 695562001011 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 695562001012 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 695562001013 catalytic core [active] 695562001014 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 695562001015 AAA domain; Region: AAA_33; pfam13671 695562001016 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 695562001017 trimer interface [polypeptide binding]; other site 695562001018 active site 695562001019 G bulge; other site 695562001020 Predicted acetyltransferase [General function prediction only]; Region: COG2388 695562001021 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 695562001022 trimer interface [polypeptide binding]; other site 695562001023 active site 695562001024 DNA repair protein RadA; Provisional; Region: PRK11823 695562001025 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 695562001026 Walker A motif/ATP binding site; other site 695562001027 ATP binding site [chemical binding]; other site 695562001028 Walker B motif; other site 695562001029 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 695562001030 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 695562001031 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 695562001032 active site 695562001033 HIGH motif; other site 695562001034 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 695562001035 active site 695562001036 KMSKS motif; other site 695562001037 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 695562001038 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 695562001039 active site 695562001040 HIGH motif; other site 695562001041 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 695562001042 KMSKS motif; other site 695562001043 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 695562001044 tRNA binding surface [nucleotide binding]; other site 695562001045 anticodon binding site; other site 695562001046 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 695562001047 active site 695562001048 metal binding site [ion binding]; metal-binding site 695562001049 dimerization interface [polypeptide binding]; other site 695562001050 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 695562001051 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 695562001052 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 695562001053 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 695562001054 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 695562001055 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 695562001056 N- and C-terminal domain interface [polypeptide binding]; other site 695562001057 active site 695562001058 catalytic site [active] 695562001059 metal binding site [ion binding]; metal-binding site 695562001060 carbohydrate binding site [chemical binding]; other site 695562001061 ATP binding site [chemical binding]; other site 695562001062 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 695562001063 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 695562001064 TPP-binding site; other site 695562001065 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 695562001066 PYR/PP interface [polypeptide binding]; other site 695562001067 dimer interface [polypeptide binding]; other site 695562001068 TPP binding site [chemical binding]; other site 695562001069 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 695562001070 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 695562001071 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 695562001072 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 695562001073 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 695562001074 putative homodimer interface [polypeptide binding]; other site 695562001075 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 695562001076 heterodimer interface [polypeptide binding]; other site 695562001077 homodimer interface [polypeptide binding]; other site 695562001078 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 695562001079 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 695562001080 23S rRNA interface [nucleotide binding]; other site 695562001081 L7/L12 interface [polypeptide binding]; other site 695562001082 putative thiostrepton binding site; other site 695562001083 L25 interface [polypeptide binding]; other site 695562001084 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 695562001085 mRNA/rRNA interface [nucleotide binding]; other site 695562001086 potential frameshift: common BLAST hit: gi|58336714|ref|YP_193299.1| transposase 695562001087 PBP superfamily domain; Region: PBP_like_2; cl17296 695562001088 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 695562001089 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 695562001090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 695562001091 dimer interface [polypeptide binding]; other site 695562001092 conserved gate region; other site 695562001093 putative PBP binding loops; other site 695562001094 ABC-ATPase subunit interface; other site 695562001095 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 695562001096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 695562001097 dimer interface [polypeptide binding]; other site 695562001098 conserved gate region; other site 695562001099 putative PBP binding loops; other site 695562001100 ABC-ATPase subunit interface; other site 695562001101 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 695562001102 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 695562001103 Walker A/P-loop; other site 695562001104 ATP binding site [chemical binding]; other site 695562001105 Q-loop/lid; other site 695562001106 ABC transporter signature motif; other site 695562001107 Walker B; other site 695562001108 D-loop; other site 695562001109 H-loop/switch region; other site 695562001110 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14251 695562001111 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 695562001112 Walker A/P-loop; other site 695562001113 ATP binding site [chemical binding]; other site 695562001114 Q-loop/lid; other site 695562001115 ABC transporter signature motif; other site 695562001116 Walker B; other site 695562001117 D-loop; other site 695562001118 H-loop/switch region; other site 695562001119 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 695562001120 PhoU domain; Region: PhoU; pfam01895 695562001121 PhoU domain; Region: PhoU; pfam01895 695562001122 Membrane transport protein; Region: Mem_trans; cl09117 695562001123 Membrane transport protein; Region: Mem_trans; cl09117 695562001124 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 695562001125 23S rRNA interface [nucleotide binding]; other site 695562001126 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 695562001127 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 695562001128 core dimer interface [polypeptide binding]; other site 695562001129 peripheral dimer interface [polypeptide binding]; other site 695562001130 L10 interface [polypeptide binding]; other site 695562001131 L11 interface [polypeptide binding]; other site 695562001132 putative EF-Tu interaction site [polypeptide binding]; other site 695562001133 putative EF-G interaction site [polypeptide binding]; other site 695562001134 Ion channel; Region: Ion_trans_2; pfam07885 695562001135 Protein of unknown function (DUF904); Region: DUF904; pfam06005 695562001136 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 695562001137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 695562001138 S-adenosylmethionine binding site [chemical binding]; other site 695562001139 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 695562001140 nucleoside/Zn binding site; other site 695562001141 dimer interface [polypeptide binding]; other site 695562001142 catalytic motif [active] 695562001143 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 695562001144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 695562001145 Walker A motif; other site 695562001146 ATP binding site [chemical binding]; other site 695562001147 Walker B motif; other site 695562001148 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 695562001149 hypothetical protein; Validated; Region: PRK00153 695562001150 recombination protein RecR; Reviewed; Region: recR; PRK00076 695562001151 RecR protein; Region: RecR; pfam02132 695562001152 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 695562001153 putative active site [active] 695562001154 putative metal-binding site [ion binding]; other site 695562001155 tetramer interface [polypeptide binding]; other site 695562001156 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 695562001157 thymidylate kinase; Validated; Region: tmk; PRK00698 695562001158 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 695562001159 TMP-binding site; other site 695562001160 ATP-binding site [chemical binding]; other site 695562001161 Protein of unknown function (DUF970); Region: DUF970; cl17525 695562001162 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 695562001163 DNA polymerase III subunit delta'; Validated; Region: PRK08485 695562001164 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 695562001165 Predicted methyltransferases [General function prediction only]; Region: COG0313 695562001166 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 695562001167 putative SAM binding site [chemical binding]; other site 695562001168 putative homodimer interface [polypeptide binding]; other site 695562001169 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 695562001170 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 695562001171 active site 695562001172 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 695562001173 active site 2 [active] 695562001174 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 695562001175 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 695562001176 Glycoprotease family; Region: Peptidase_M22; pfam00814 695562001177 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 695562001178 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 695562001179 Coenzyme A binding pocket [chemical binding]; other site 695562001180 UGMP family protein; Validated; Region: PRK09604 695562001181 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 695562001182 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 695562001183 CoA-transferase family III; Region: CoA_transf_3; pfam02515 695562001184 formyl-coenzyme A transferase; Provisional; Region: PRK05398 695562001185 CoA-transferase family III; Region: CoA_transf_3; pfam02515 695562001186 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 695562001187 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 695562001188 PYR/PP interface [polypeptide binding]; other site 695562001189 dimer interface [polypeptide binding]; other site 695562001190 TPP binding site [chemical binding]; other site 695562001191 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 695562001192 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 695562001193 TPP-binding site; other site 695562001194 dimer interface [polypeptide binding]; other site 695562001195 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 695562001196 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 695562001197 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 695562001198 ABC transporter; Region: ABC_tran_2; pfam12848 695562001199 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 695562001200 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 695562001201 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 695562001202 CoA binding domain; Region: CoA_binding; pfam02629 695562001203 Transcriptional regulators [Transcription]; Region: PurR; COG1609 695562001204 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 695562001205 DNA binding site [nucleotide binding] 695562001206 domain linker motif; other site 695562001207 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 695562001208 dimerization interface [polypeptide binding]; other site 695562001209 ligand binding site [chemical binding]; other site 695562001210 sodium binding site [ion binding]; other site 695562001211 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 695562001212 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 695562001213 substrate binding [chemical binding]; other site 695562001214 active site 695562001215 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 695562001216 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 695562001217 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 695562001218 active site turn [active] 695562001219 phosphorylation site [posttranslational modification] 695562001220 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 695562001221 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 695562001222 HPr interaction site; other site 695562001223 glycerol kinase (GK) interaction site [polypeptide binding]; other site 695562001224 active site 695562001225 phosphorylation site [posttranslational modification] 695562001226 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 695562001227 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 695562001228 non-specific DNA binding site [nucleotide binding]; other site 695562001229 salt bridge; other site 695562001230 sequence-specific DNA binding site [nucleotide binding]; other site 695562001231 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 695562001232 LytTr DNA-binding domain; Region: LytTR; smart00850 695562001233 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 695562001234 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 695562001235 oligomerisation interface [polypeptide binding]; other site 695562001236 mobile loop; other site 695562001237 roof hairpin; other site 695562001238 chaperonin GroL; Region: GroEL; TIGR02348 695562001239 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 695562001240 ring oligomerisation interface [polypeptide binding]; other site 695562001241 ATP/Mg binding site [chemical binding]; other site 695562001242 stacking interactions; other site 695562001243 hinge regions; other site 695562001244 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 695562001245 MutS domain I; Region: MutS_I; pfam01624 695562001246 MutS domain II; Region: MutS_II; pfam05188 695562001247 MutS domain III; Region: MutS_III; pfam05192 695562001248 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 695562001249 Walker A/P-loop; other site 695562001250 ATP binding site [chemical binding]; other site 695562001251 Q-loop/lid; other site 695562001252 ABC transporter signature motif; other site 695562001253 Walker B; other site 695562001254 D-loop; other site 695562001255 H-loop/switch region; other site 695562001256 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 695562001257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 695562001258 ATP binding site [chemical binding]; other site 695562001259 Mg2+ binding site [ion binding]; other site 695562001260 G-X-G motif; other site 695562001261 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 695562001262 ATP binding site [chemical binding]; other site 695562001263 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 695562001264 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 695562001265 RuvA N terminal domain; Region: RuvA_N; pfam01330 695562001266 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 695562001267 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 695562001268 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 695562001269 Walker A motif; other site 695562001270 ATP binding site [chemical binding]; other site 695562001271 Walker B motif; other site 695562001272 arginine finger; other site 695562001273 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 695562001274 Preprotein translocase subunit; Region: YajC; pfam02699 695562001275 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 695562001276 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 695562001277 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 695562001278 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 695562001279 active site 695562001280 DNA polymerase IV; Validated; Region: PRK02406 695562001281 DNA binding site [nucleotide binding] 695562001282 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 695562001283 DHH family; Region: DHH; pfam01368 695562001284 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 695562001285 DEAD-like helicases superfamily; Region: DEXDc; smart00487 695562001286 ATP binding site [chemical binding]; other site 695562001287 putative Mg++ binding site [ion binding]; other site 695562001288 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 695562001289 nucleotide binding region [chemical binding]; other site 695562001290 ATP-binding site [chemical binding]; other site 695562001291 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 695562001292 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 695562001293 motif 1; other site 695562001294 active site 695562001295 motif 2; other site 695562001296 motif 3; other site 695562001297 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 695562001298 DHHA1 domain; Region: DHHA1; pfam02272 695562001299 hypothetical protein; Provisional; Region: PRK05473 695562001300 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 695562001301 hypothetical protein; Provisional; Region: PRK13678 695562001302 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 695562001303 MutS domain III; Region: MutS_III; pfam05192 695562001304 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 695562001305 Walker A/P-loop; other site 695562001306 ATP binding site [chemical binding]; other site 695562001307 Q-loop/lid; other site 695562001308 ABC transporter signature motif; other site 695562001309 Walker B; other site 695562001310 D-loop; other site 695562001311 H-loop/switch region; other site 695562001312 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 695562001313 Smr domain; Region: Smr; pfam01713 695562001314 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 695562001315 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 695562001316 catalytic residues [active] 695562001317 Transposase; Region: DEDD_Tnp_IS110; pfam01548 695562001318 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 695562001319 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 695562001320 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 695562001321 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 695562001322 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 695562001323 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 695562001324 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 695562001325 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 695562001326 active site 695562001327 dimerization interface [polypeptide binding]; other site 695562001328 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 695562001329 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 695562001330 Mechanosensitive ion channel; Region: MS_channel; pfam00924 695562001331 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 695562001332 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 695562001333 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 695562001334 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 695562001335 active site 695562001336 catabolite control protein A; Region: ccpA; TIGR01481 695562001337 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 695562001338 DNA binding site [nucleotide binding] 695562001339 domain linker motif; other site 695562001340 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 695562001341 dimerization interface [polypeptide binding]; other site 695562001342 effector binding site; other site 695562001343 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 695562001344 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 695562001345 active site 695562001346 catalytic site [active] 695562001347 metal binding site [ion binding]; metal-binding site 695562001348 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 695562001349 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 695562001350 active site 695562001351 metal binding site [ion binding]; metal-binding site 695562001352 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 695562001353 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 695562001354 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 695562001355 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 695562001356 active site 695562001357 motif I; other site 695562001358 motif II; other site 695562001359 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 695562001360 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 695562001361 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 695562001362 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 695562001363 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 695562001364 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 695562001365 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 695562001366 active site 695562001367 8-oxo-dGMP binding site [chemical binding]; other site 695562001368 nudix motif; other site 695562001369 metal binding site [ion binding]; metal-binding site 695562001370 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 695562001371 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 695562001372 putative ADP-binding pocket [chemical binding]; other site 695562001373 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 695562001374 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; pfam13579 695562001375 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 695562001376 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 695562001377 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 695562001378 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 695562001379 Sulfatase; Region: Sulfatase; pfam00884 695562001380 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 695562001381 ribonuclease R; Region: RNase_R; TIGR02063 695562001382 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 695562001383 RNB domain; Region: RNB; pfam00773 695562001384 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 695562001385 RNA binding site [nucleotide binding]; other site 695562001386 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 695562001387 SmpB-tmRNA interface; other site 695562001388 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 695562001389 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 695562001390 active pocket/dimerization site; other site 695562001391 active site 695562001392 phosphorylation site [posttranslational modification] 695562001393 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 695562001394 active site 695562001395 phosphorylation site [posttranslational modification] 695562001396 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 695562001397 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 695562001398 Domain of unknown function (DUF956); Region: DUF956; pfam06115 695562001399 Transcriptional regulator [Transcription]; Region: LysR; COG0583 695562001400 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 695562001401 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 695562001402 dimerization interface [polypeptide binding]; other site 695562001403 potential frameshift: common BLAST hit: gi|295692324|ref|YP_003600934.1| maltose o-acetyltransferase 695562001404 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 695562001405 Spore germination protein; Region: Spore_permease; cl17796 695562001406 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 695562001407 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 695562001408 putative catalytic cysteine [active] 695562001409 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 695562001410 putative active site [active] 695562001411 metal binding site [ion binding]; metal-binding site 695562001412 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 695562001413 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 695562001414 glutaminase active site [active] 695562001415 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 695562001416 dimer interface [polypeptide binding]; other site 695562001417 active site 695562001418 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 695562001419 dimer interface [polypeptide binding]; other site 695562001420 active site 695562001421 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 695562001422 propionate/acetate kinase; Provisional; Region: PRK12379 695562001423 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 695562001424 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 695562001425 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 695562001426 active site 695562001427 Ap4A binding cleft/pocket [chemical binding]; other site 695562001428 P4 phosphate binding site; other site 695562001429 nudix motif; other site 695562001430 putative P2/P3 phosphate binding site [ion binding]; other site 695562001431 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 695562001432 active site 695562001433 metal-binding site [ion binding] 695562001434 nucleotide-binding site [chemical binding]; other site 695562001435 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 695562001436 AAA ATPase domain; Region: AAA_16; pfam13191 695562001437 DEAD-like helicases superfamily; Region: DEXDc; smart00487 695562001438 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 695562001439 ATP binding site [chemical binding]; other site 695562001440 putative Mg++ binding site [ion binding]; other site 695562001441 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 695562001442 nucleotide binding region [chemical binding]; other site 695562001443 ATP-binding site [chemical binding]; other site 695562001444 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 695562001445 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 695562001446 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 695562001447 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 695562001448 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 695562001449 amphipathic channel; other site 695562001450 Asn-Pro-Ala signature motifs; other site 695562001451 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 695562001452 dimer interface [polypeptide binding]; other site 695562001453 FMN binding site [chemical binding]; other site 695562001454 NADPH bind site [chemical binding]; other site 695562001455 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 695562001456 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 695562001457 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 695562001458 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 695562001459 active site 695562001460 RNA/DNA hybrid binding site [nucleotide binding]; other site 695562001461 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 695562001462 NlpC/P60 family; Region: NLPC_P60; pfam00877 695562001463 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 695562001464 Plasmid replication protein; Region: Rep_2; pfam01719 695562001465 RNA helicase; Region: RNA_helicase; pfam00910 695562001466 Helix-turn-helix domain; Region: HTH_17; cl17695 695562001467 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 695562001468 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 695562001469 active site 695562001470 DNA binding site [nucleotide binding] 695562001471 Int/Topo IB signature motif; other site 695562001472 HTH-like domain; Region: HTH_21; pfam13276 695562001473 Integrase core domain; Region: rve; pfam00665 695562001474 Integrase core domain; Region: rve_2; pfam13333 695562001475 Transposase; Region: HTH_Tnp_1; cl17663 695562001476 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 695562001477 carbohydrate binding site [chemical binding]; other site 695562001478 pullulanase, type I; Region: pulA_typeI; TIGR02104 695562001479 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 695562001480 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 695562001481 Ca binding site [ion binding]; other site 695562001482 active site 695562001483 catalytic site [active] 695562001484 Bacterial surface layer protein; Region: SLAP; pfam03217 695562001485 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 695562001486 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 695562001487 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 695562001488 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 695562001489 Ligand binding site; other site 695562001490 Putative Catalytic site; other site 695562001491 DXD motif; other site 695562001492 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 695562001493 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 695562001494 active site 695562001495 metal binding site [ion binding]; metal-binding site 695562001496 potential frameshift: common BLAST hit: gi|58336822|ref|YP_193407.1| cellobiose-specific PTS IIC 695562001497 potential frameshift: common BLAST hit: gi|58336822|ref|YP_193407.1| cellobiose-specific PTS IIC 695562001498 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 695562001499 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 695562001500 catalytic core [active] 695562001501 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 695562001502 catalytic core [active] 695562001503 Uncharacterized conserved protein [Function unknown]; Region: COG1359 695562001504 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 695562001505 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 695562001506 active site 695562001507 catalytic site [active] 695562001508 magnesium-transporting ATPase; Provisional; Region: PRK15122 695562001509 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 695562001510 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 695562001511 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 695562001512 Soluble P-type ATPase [General function prediction only]; Region: COG4087 695562001513 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 695562001514 aromatic amino acid aminotransferase; Validated; Region: PRK07309 695562001515 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 695562001516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 695562001517 homodimer interface [polypeptide binding]; other site 695562001518 catalytic residue [active] 695562001519 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 695562001520 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 695562001521 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 695562001522 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 695562001523 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 695562001524 Bacterial surface layer protein; Region: SLAP; pfam03217 695562001525 DNA polymerase IV; Reviewed; Region: PRK03103 695562001526 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 695562001527 active site 695562001528 DNA binding site [nucleotide binding] 695562001529 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 695562001530 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 695562001531 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 695562001532 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 695562001533 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 695562001534 DNA-binding site [nucleotide binding]; DNA binding site 695562001535 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 695562001536 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 695562001537 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 695562001538 active site 695562001539 nucleotide binding site [chemical binding]; other site 695562001540 HIGH motif; other site 695562001541 KMSKS motif; other site 695562001542 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 695562001543 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 695562001544 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 695562001545 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 695562001546 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 695562001547 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 695562001548 active site 695562001549 NAD synthetase; Reviewed; Region: nadE; PRK00768 695562001550 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 695562001551 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 695562001552 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 695562001553 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 695562001554 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 695562001555 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 695562001556 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 695562001557 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 695562001558 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 695562001559 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 695562001560 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 695562001561 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 695562001562 hypothetical protein; Provisional; Region: PRK04351 695562001563 SprT homologues; Region: SprT; cl01182 695562001564 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 695562001565 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 695562001566 Part of AAA domain; Region: AAA_19; pfam13245 695562001567 Family description; Region: UvrD_C_2; pfam13538 695562001568 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 695562001569 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 695562001570 nucleotide binding pocket [chemical binding]; other site 695562001571 K-X-D-G motif; other site 695562001572 catalytic site [active] 695562001573 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 695562001574 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 695562001575 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 695562001576 Dimer interface [polypeptide binding]; other site 695562001577 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 695562001578 putative dimer interface [polypeptide binding]; other site 695562001579 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 695562001580 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 695562001581 putative dimer interface [polypeptide binding]; other site 695562001582 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 695562001583 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 695562001584 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 695562001585 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 695562001586 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 695562001587 GatB domain; Region: GatB_Yqey; smart00845 695562001588 putative lipid kinase; Reviewed; Region: PRK13337 695562001589 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 695562001590 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 695562001591 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 695562001592 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 695562001593 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 695562001594 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 695562001595 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 695562001596 S-adenosylmethionine binding site [chemical binding]; other site 695562001597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 695562001598 Coenzyme A binding pocket [chemical binding]; other site 695562001599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 695562001600 Major Facilitator Superfamily; Region: MFS_1; pfam07690 695562001601 putative substrate translocation pore; other site 695562001602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 695562001603 potential frameshift: common BLAST hit: gi|295692419|ref|YP_003601029.1| transcriptional regulator 695562001604 myosin-cross-reactive antigen; Provisional; Region: PRK13977 695562001605 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 695562001606 Coenzyme A binding pocket [chemical binding]; other site 695562001607 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 695562001608 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 695562001609 non-specific DNA binding site [nucleotide binding]; other site 695562001610 salt bridge; other site 695562001611 sequence-specific DNA binding site [nucleotide binding]; other site 695562001612 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 695562001613 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 695562001614 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 695562001615 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 695562001616 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 695562001617 active pocket/dimerization site; other site 695562001618 active site 695562001619 phosphorylation site [posttranslational modification] 695562001620 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 695562001621 active site 695562001622 phosphorylation site [posttranslational modification] 695562001623 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 695562001624 Bacterial surface layer protein; Region: SLAP; pfam03217 695562001625 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 695562001626 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 695562001627 active site 695562001628 catalytic tetrad [active] 695562001629 uracil transporter; Provisional; Region: PRK10720 695562001630 Sulfate transporter family; Region: Sulfate_transp; pfam00916 695562001631 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 695562001632 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 695562001633 active site 695562001634 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 695562001635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 695562001636 Major Facilitator Superfamily; Region: MFS_1; pfam07690 695562001637 putative substrate translocation pore; other site 695562001638 drug efflux system protein MdtG; Provisional; Region: PRK09874 695562001639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 695562001640 putative substrate translocation pore; other site 695562001641 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 695562001642 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 695562001643 oligomer interface [polypeptide binding]; other site 695562001644 active site 695562001645 metal binding site [ion binding]; metal-binding site 695562001646 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 695562001647 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 695562001648 Walker A/P-loop; other site 695562001649 ATP binding site [chemical binding]; other site 695562001650 Q-loop/lid; other site 695562001651 ABC transporter signature motif; other site 695562001652 Walker B; other site 695562001653 D-loop; other site 695562001654 H-loop/switch region; other site 695562001655 ABC transporter; Region: ABC_tran_2; pfam12848 695562001656 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 695562001657 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 695562001658 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 695562001659 active site 695562001660 catalytic tetrad [active] 695562001661 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 695562001662 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 695562001663 substrate binding pocket [chemical binding]; other site 695562001664 membrane-bound complex binding site; other site 695562001665 hinge residues; other site 695562001666 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 695562001667 Transcriptional regulators [Transcription]; Region: MarR; COG1846 695562001668 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 695562001669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 695562001670 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 695562001671 Walker A/P-loop; other site 695562001672 ATP binding site [chemical binding]; other site 695562001673 Q-loop/lid; other site 695562001674 ABC transporter signature motif; other site 695562001675 Walker B; other site 695562001676 D-loop; other site 695562001677 H-loop/switch region; other site 695562001678 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 695562001679 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 695562001680 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 695562001681 Walker A/P-loop; other site 695562001682 ATP binding site [chemical binding]; other site 695562001683 Q-loop/lid; other site 695562001684 ABC transporter signature motif; other site 695562001685 Walker B; other site 695562001686 D-loop; other site 695562001687 H-loop/switch region; other site 695562001688 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 695562001689 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 695562001690 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 695562001691 Sugar specificity; other site 695562001692 Pyrimidine base specificity; other site 695562001693 ATP-binding site [chemical binding]; other site 695562001694 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 695562001695 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 695562001696 Walker A/P-loop; other site 695562001697 ATP binding site [chemical binding]; other site 695562001698 Q-loop/lid; other site 695562001699 ABC transporter signature motif; other site 695562001700 Walker B; other site 695562001701 D-loop; other site 695562001702 H-loop/switch region; other site 695562001703 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 695562001704 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 695562001705 substrate binding pocket [chemical binding]; other site 695562001706 membrane-bound complex binding site; other site 695562001707 hinge residues; other site 695562001708 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 695562001709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 695562001710 dimer interface [polypeptide binding]; other site 695562001711 conserved gate region; other site 695562001712 putative PBP binding loops; other site 695562001713 ABC-ATPase subunit interface; other site 695562001714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 695562001715 dimer interface [polypeptide binding]; other site 695562001716 conserved gate region; other site 695562001717 putative PBP binding loops; other site 695562001718 ABC-ATPase subunit interface; other site 695562001719 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 695562001720 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 695562001721 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 695562001722 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 695562001723 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 695562001724 nucleotide binding site/active site [active] 695562001725 HIT family signature motif; other site 695562001726 catalytic residue [active] 695562001727 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 695562001728 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 695562001729 substrate binding site [chemical binding]; other site 695562001730 dimer interface [polypeptide binding]; other site 695562001731 ATP binding site [chemical binding]; other site 695562001732 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 695562001733 tetramer (dimer of dimers) interface [polypeptide binding]; other site 695562001734 active site 695562001735 dimer interface [polypeptide binding]; other site 695562001736 K+ potassium transporter; Region: K_trans; pfam02705 695562001737 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 695562001738 active site 695562001739 tetramer interface [polypeptide binding]; other site 695562001740 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 695562001741 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 695562001742 DNA-binding site [nucleotide binding]; DNA binding site 695562001743 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 695562001744 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 695562001745 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 695562001746 Enterocin A Immunity; Region: EntA_Immun; pfam08951 695562001747 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 695562001748 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 695562001749 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 695562001750 putative phosphoketolase; Provisional; Region: PRK05261 695562001751 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 695562001752 TPP-binding site; other site 695562001753 XFP C-terminal domain; Region: XFP_C; pfam09363 695562001754 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 695562001755 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 695562001756 active site 695562001757 nucleophile elbow; other site 695562001758 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 695562001759 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 695562001760 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 695562001761 active site turn [active] 695562001762 phosphorylation site [posttranslational modification] 695562001763 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 695562001764 active site turn [active] 695562001765 phosphorylation site [posttranslational modification] 695562001766 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 695562001767 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 695562001768 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 695562001769 putative active site [active] 695562001770 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 695562001771 HPr interaction site; other site 695562001772 glycerol kinase (GK) interaction site [polypeptide binding]; other site 695562001773 active site 695562001774 phosphorylation site [posttranslational modification] 695562001775 IncA protein; Region: IncA; pfam04156 695562001776 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 695562001777 putative FMN binding site [chemical binding]; other site 695562001778 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 695562001779 Domain of unknown function DUF21; Region: DUF21; pfam01595 695562001780 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 695562001781 Transporter associated domain; Region: CorC_HlyC; smart01091 695562001782 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 695562001783 active site 695562001784 Amino acid permease; Region: AA_permease_2; pfam13520 695562001785 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 695562001786 active site 695562001787 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 695562001788 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 695562001789 DEAD-like helicases superfamily; Region: DEXDc; smart00487 695562001790 ATP binding site [chemical binding]; other site 695562001791 putative Mg++ binding site [ion binding]; other site 695562001792 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 695562001793 nucleotide binding region [chemical binding]; other site 695562001794 ATP-binding site [chemical binding]; other site 695562001795 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 695562001796 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 695562001797 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 695562001798 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 695562001799 active site 695562001800 homodimer interface [polypeptide binding]; other site 695562001801 Predicted membrane protein [Function unknown]; Region: COG2246 695562001802 GtrA-like protein; Region: GtrA; pfam04138 695562001803 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 695562001804 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 695562001805 methionine aminopeptidase; Provisional; Region: PRK08671 695562001806 active site 695562001807 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 695562001808 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 695562001809 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 695562001810 active site 695562001811 tetramer interface; other site 695562001812 putative acyltransferase; Provisional; Region: PRK05790 695562001813 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 695562001814 dimer interface [polypeptide binding]; other site 695562001815 active site 695562001816 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 695562001817 homodimer interface [polypeptide binding]; other site 695562001818 catalytic residues [active] 695562001819 NAD binding site [chemical binding]; other site 695562001820 substrate binding pocket [chemical binding]; other site 695562001821 flexible flap; other site 695562001822 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 695562001823 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 695562001824 dimer interface [polypeptide binding]; other site 695562001825 active site 695562001826 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 695562001827 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 695562001828 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 695562001829 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 695562001830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 695562001831 S-adenosylmethionine binding site [chemical binding]; other site 695562001832 recombination regulator RecX; Provisional; Region: recX; PRK14135 695562001833 Flavoprotein; Region: Flavoprotein; cl08021 695562001834 FOG: CBS domain [General function prediction only]; Region: COG0517 695562001835 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 695562001836 Transporter associated domain; Region: CorC_HlyC; pfam03471 695562001837 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 695562001838 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 695562001839 G1 box; other site 695562001840 putative GEF interaction site [polypeptide binding]; other site 695562001841 GTP/Mg2+ binding site [chemical binding]; other site 695562001842 Switch I region; other site 695562001843 G2 box; other site 695562001844 G3 box; other site 695562001845 Switch II region; other site 695562001846 G4 box; other site 695562001847 G5 box; other site 695562001848 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 695562001849 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 695562001850 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 695562001851 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 695562001852 Walker A motif; other site 695562001853 ATP binding site [chemical binding]; other site 695562001854 Walker B motif; other site 695562001855 arginine finger; other site 695562001856 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 695562001857 Walker A motif; other site 695562001858 ATP binding site [chemical binding]; other site 695562001859 Walker B motif; other site 695562001860 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 695562001861 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 695562001862 dimerization domain swap beta strand [polypeptide binding]; other site 695562001863 regulatory protein interface [polypeptide binding]; other site 695562001864 active site 695562001865 regulatory phosphorylation site [posttranslational modification]; other site 695562001866 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 695562001867 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 695562001868 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 695562001869 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 695562001870 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 695562001871 ArsC family; Region: ArsC; pfam03960 695562001872 putative catalytic residues [active] 695562001873 thiol/disulfide switch; other site 695562001874 adaptor protein; Provisional; Region: PRK02315 695562001875 Competence protein CoiA-like family; Region: CoiA; cl11541 695562001876 Thioredoxin; Region: Thioredoxin_5; pfam13743 695562001877 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 695562001878 putative active site [active] 695562001879 putative metal binding residues [ion binding]; other site 695562001880 signature motif; other site 695562001881 putative triphosphate binding site [ion binding]; other site 695562001882 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 695562001883 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 695562001884 synthetase active site [active] 695562001885 NTP binding site [chemical binding]; other site 695562001886 metal binding site [ion binding]; metal-binding site 695562001887 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 695562001888 ATP-NAD kinase; Region: NAD_kinase; pfam01513 695562001889 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 695562001890 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 695562001891 active site 695562001892 myosin-cross-reactive antigen; Provisional; Region: PRK13977 695562001893 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 695562001894 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 695562001895 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 695562001896 active site 695562001897 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 695562001898 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 695562001899 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 695562001900 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 695562001901 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 695562001902 active site 695562001903 motif I; other site 695562001904 motif II; other site 695562001905 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 695562001906 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 695562001907 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 695562001908 Domain of unknown function DUF20; Region: UPF0118; pfam01594 695562001909 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 695562001910 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 695562001911 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 695562001912 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 695562001913 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 695562001914 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 695562001915 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 695562001916 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 695562001917 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 695562001918 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 695562001919 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 695562001920 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 695562001921 classical (c) SDRs; Region: SDR_c; cd05233 695562001922 NAD(P) binding site [chemical binding]; other site 695562001923 active site 695562001924 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 695562001925 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 695562001926 non-specific DNA binding site [nucleotide binding]; other site 695562001927 salt bridge; other site 695562001928 sequence-specific DNA binding site [nucleotide binding]; other site 695562001929 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 695562001930 recombinase A; Provisional; Region: recA; PRK09354 695562001931 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 695562001932 hexamer interface [polypeptide binding]; other site 695562001933 Walker A motif; other site 695562001934 ATP binding site [chemical binding]; other site 695562001935 Walker B motif; other site 695562001936 phosphodiesterase; Provisional; Region: PRK12704 695562001937 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 695562001938 Zn2+ binding site [ion binding]; other site 695562001939 Mg2+ binding site [ion binding]; other site 695562001940 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 695562001941 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 695562001942 Mg++ binding site [ion binding]; other site 695562001943 putative catalytic motif [active] 695562001944 substrate binding site [chemical binding]; other site 695562001945 Uncharacterized conserved protein [Function unknown]; Region: COG1739 695562001946 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 695562001947 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 695562001948 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 695562001949 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 695562001950 ATP binding site [chemical binding]; other site 695562001951 putative Mg++ binding site [ion binding]; other site 695562001952 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 695562001953 nucleotide binding region [chemical binding]; other site 695562001954 ATP-binding site [chemical binding]; other site 695562001955 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 695562001956 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 695562001957 active site 695562001958 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 695562001959 30S subunit binding site; other site 695562001960 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 695562001961 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 695562001962 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 695562001963 nucleotide binding region [chemical binding]; other site 695562001964 ATP-binding site [chemical binding]; other site 695562001965 peptide chain release factor 2; Provisional; Region: PRK05589 695562001966 This domain is found in peptide chain release factors; Region: PCRF; smart00937 695562001967 RF-1 domain; Region: RF-1; pfam00472 695562001968 HPr kinase/phosphorylase; Provisional; Region: PRK05428 695562001969 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 695562001970 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 695562001971 Hpr binding site; other site 695562001972 active site 695562001973 homohexamer subunit interaction site [polypeptide binding]; other site 695562001974 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 695562001975 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 695562001976 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 695562001977 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 695562001978 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 695562001979 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 695562001980 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 695562001981 glycogen branching enzyme; Provisional; Region: PRK12313 695562001982 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 695562001983 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 695562001984 active site 695562001985 catalytic site [active] 695562001986 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 695562001987 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 695562001988 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 695562001989 ligand binding site; other site 695562001990 oligomer interface; other site 695562001991 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 695562001992 dimer interface [polypeptide binding]; other site 695562001993 N-terminal domain interface [polypeptide binding]; other site 695562001994 sulfate 1 binding site; other site 695562001995 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 695562001996 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 695562001997 active site 695562001998 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 695562001999 dimer interface [polypeptide binding]; other site 695562002000 N-terminal domain interface [polypeptide binding]; other site 695562002001 sulfate 1 binding site; other site 695562002002 glycogen synthase; Provisional; Region: glgA; PRK00654 695562002003 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 695562002004 ADP-binding pocket [chemical binding]; other site 695562002005 homodimer interface [polypeptide binding]; other site 695562002006 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 695562002007 homodimer interface [polypeptide binding]; other site 695562002008 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 695562002009 active site pocket [active] 695562002010 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 695562002011 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 695562002012 active site 695562002013 homodimer interface [polypeptide binding]; other site 695562002014 catalytic site [active] 695562002015 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 695562002016 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 695562002017 active site 695562002018 substrate binding site [chemical binding]; other site 695562002019 metal binding site [ion binding]; metal-binding site 695562002020 excinuclease ABC subunit B; Provisional; Region: PRK05298 695562002021 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 695562002022 ATP binding site [chemical binding]; other site 695562002023 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 695562002024 nucleotide binding region [chemical binding]; other site 695562002025 ATP-binding site [chemical binding]; other site 695562002026 Ultra-violet resistance protein B; Region: UvrB; pfam12344 695562002027 UvrB/uvrC motif; Region: UVR; pfam02151 695562002028 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 695562002029 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 695562002030 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 695562002031 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 695562002032 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 695562002033 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 695562002034 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 695562002035 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 695562002036 phosphate binding site [ion binding]; other site 695562002037 putative substrate binding pocket [chemical binding]; other site 695562002038 dimer interface [polypeptide binding]; other site 695562002039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 695562002040 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 695562002041 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 695562002042 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 695562002043 oligomer interface [polypeptide binding]; other site 695562002044 active site residues [active] 695562002045 SH3-like domain; Region: SH3_8; pfam13457 695562002046 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 695562002047 inner membrane transporter YjeM; Provisional; Region: PRK15238 695562002048 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 695562002049 Helix-turn-helix domain; Region: HTH_38; pfam13936 695562002050 Predicted transcriptional regulator [Transcription]; Region: COG3388 695562002051 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 695562002052 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 695562002053 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 695562002054 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 695562002055 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 695562002056 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 695562002057 Phosphoglycerate kinase; Region: PGK; pfam00162 695562002058 substrate binding site [chemical binding]; other site 695562002059 hinge regions; other site 695562002060 ADP binding site [chemical binding]; other site 695562002061 catalytic site [active] 695562002062 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 695562002063 triosephosphate isomerase; Provisional; Region: PRK14567 695562002064 substrate binding site [chemical binding]; other site 695562002065 dimer interface [polypeptide binding]; other site 695562002066 catalytic triad [active] 695562002067 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 695562002068 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 695562002069 active site 695562002070 motif I; other site 695562002071 motif II; other site 695562002072 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 695562002073 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 695562002074 ligand binding site [chemical binding]; other site 695562002075 active site 695562002076 UGI interface [polypeptide binding]; other site 695562002077 catalytic site [active] 695562002078 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 695562002079 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 695562002080 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 695562002081 acetyl esterase; Provisional; Region: PRK10162 695562002082 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 695562002083 active site 695562002084 catalytic site [active] 695562002085 substrate binding site [chemical binding]; other site 695562002086 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 695562002087 FAD binding domain; Region: FAD_binding_4; pfam01565 695562002088 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 695562002089 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 695562002090 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 695562002091 Walker A/P-loop; other site 695562002092 ATP binding site [chemical binding]; other site 695562002093 Q-loop/lid; other site 695562002094 ABC transporter signature motif; other site 695562002095 Walker B; other site 695562002096 D-loop; other site 695562002097 H-loop/switch region; other site 695562002098 TOBE domain; Region: TOBE_2; pfam08402 695562002099 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 695562002100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 695562002101 putative PBP binding loops; other site 695562002102 ABC-ATPase subunit interface; other site 695562002103 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 695562002104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 695562002105 dimer interface [polypeptide binding]; other site 695562002106 conserved gate region; other site 695562002107 putative PBP binding loops; other site 695562002108 ABC-ATPase subunit interface; other site 695562002109 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 695562002110 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 695562002111 Uncharacterized conserved protein [Function unknown]; Region: COG1624 695562002112 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 695562002113 YbbR-like protein; Region: YbbR; pfam07949 695562002114 YbbR-like protein; Region: YbbR; pfam07949 695562002115 YbbR-like protein; Region: YbbR; pfam07949 695562002116 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 695562002117 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 695562002118 active site 695562002119 substrate binding site [chemical binding]; other site 695562002120 metal binding site [ion binding]; metal-binding site 695562002121 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 695562002122 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 695562002123 active site 695562002124 motif I; other site 695562002125 motif II; other site 695562002126 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 695562002127 sugar phosphate phosphatase; Provisional; Region: PRK10513 695562002128 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 695562002129 active site 695562002130 motif I; other site 695562002131 motif II; other site 695562002132 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 695562002133 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 695562002134 Low molecular weight phosphatase family; Region: LMWPc; cd00115 695562002135 active site 695562002136 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 695562002137 CAT RNA binding domain; Region: CAT_RBD; cl03904 695562002138 PRD domain; Region: PRD; pfam00874 695562002139 PRD domain; Region: PRD; pfam00874 695562002140 potential frameshift: common BLAST hit: gi|58337042|ref|YP_193627.1| phosphotransferase system enzyme II 695562002141 potential frameshift: common BLAST hit: gi|58337042|ref|YP_193627.1| phosphotransferase system enzyme II 695562002142 potential frameshift: common BLAST hit: gi|58337042|ref|YP_193627.1| phosphotransferase system enzyme II 695562002143 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 695562002144 beta-galactosidase; Region: BGL; TIGR03356 695562002145 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 695562002146 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 695562002147 Amino acid permease; Region: AA_permease_2; pfam13520 695562002148 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 695562002149 VanZ like family; Region: VanZ; cl01971 695562002150 hypothetical protein; Validated; Region: PRK00110 695562002151 Type II/IV secretion system protein; Region: T2SE; pfam00437 695562002152 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 695562002153 Walker A motif; other site 695562002154 ATP binding site [chemical binding]; other site 695562002155 Walker B motif; other site 695562002156 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 695562002157 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 695562002158 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 695562002159 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 695562002160 Methyltransferase domain; Region: Methyltransf_26; pfam13659 695562002161 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 695562002162 propionate/acetate kinase; Provisional; Region: PRK12379 695562002163 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 695562002164 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; cl09752 695562002165 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 695562002166 Helix-turn-helix domain; Region: HTH_17; pfam12728 695562002167 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 695562002168 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 695562002169 non-specific DNA binding site [nucleotide binding]; other site 695562002170 salt bridge; other site 695562002171 sequence-specific DNA binding site [nucleotide binding]; other site 695562002172 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 695562002173 Int/Topo IB signature motif; other site 695562002174 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 695562002175 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 695562002176 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 695562002177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 695562002178 homodimer interface [polypeptide binding]; other site 695562002179 catalytic residue [active] 695562002180 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 695562002181 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 695562002182 SdpI/YhfL protein family; Region: SdpI; pfam13630 695562002183 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 695562002184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 695562002185 active site 695562002186 phosphorylation site [posttranslational modification] 695562002187 intermolecular recognition site; other site 695562002188 dimerization interface [polypeptide binding]; other site 695562002189 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 695562002190 DNA binding site [nucleotide binding] 695562002191 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 695562002192 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 695562002193 dimerization interface [polypeptide binding]; other site 695562002194 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 695562002195 dimer interface [polypeptide binding]; other site 695562002196 phosphorylation site [posttranslational modification] 695562002197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 695562002198 ATP binding site [chemical binding]; other site 695562002199 Mg2+ binding site [ion binding]; other site 695562002200 G-X-G motif; other site 695562002201 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 695562002202 Sulfatase; Region: Sulfatase; pfam00884 695562002203 VanZ like family; Region: VanZ; pfam04892 695562002204 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 695562002205 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 695562002206 active site 695562002207 dimer interface [polypeptide binding]; other site 695562002208 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 695562002209 dimer interface [polypeptide binding]; other site 695562002210 active site 695562002211 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 695562002212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 695562002213 putative substrate translocation pore; other site 695562002214 Beta-lactamase; Region: Beta-lactamase; pfam00144 695562002215 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 695562002216 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 695562002217 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 695562002218 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 695562002219 thymidine kinase; Provisional; Region: PRK04296 695562002220 peptide chain release factor 1; Validated; Region: prfA; PRK00591 695562002221 This domain is found in peptide chain release factors; Region: PCRF; smart00937 695562002222 RF-1 domain; Region: RF-1; pfam00472 695562002223 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 695562002224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 695562002225 S-adenosylmethionine binding site [chemical binding]; other site 695562002226 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 695562002227 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 695562002228 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 695562002229 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 695562002230 active site 695562002231 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 695562002232 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 695562002233 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 695562002234 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 695562002235 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 695562002236 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 695562002237 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 695562002238 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 695562002239 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 695562002240 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 695562002241 beta subunit interaction interface [polypeptide binding]; other site 695562002242 Walker A motif; other site 695562002243 ATP binding site [chemical binding]; other site 695562002244 Walker B motif; other site 695562002245 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 695562002246 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 695562002247 core domain interface [polypeptide binding]; other site 695562002248 delta subunit interface [polypeptide binding]; other site 695562002249 epsilon subunit interface [polypeptide binding]; other site 695562002250 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 695562002251 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 695562002252 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 695562002253 alpha subunit interaction interface [polypeptide binding]; other site 695562002254 Walker A motif; other site 695562002255 ATP binding site [chemical binding]; other site 695562002256 Walker B motif; other site 695562002257 inhibitor binding site; inhibition site 695562002258 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 695562002259 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 695562002260 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 695562002261 gamma subunit interface [polypeptide binding]; other site 695562002262 epsilon subunit interface [polypeptide binding]; other site 695562002263 LBP interface [polypeptide binding]; other site 695562002264 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 695562002265 rod shape-determining protein MreB; Provisional; Region: PRK13930 695562002266 MreB and similar proteins; Region: MreB_like; cd10225 695562002267 nucleotide binding site [chemical binding]; other site 695562002268 Mg binding site [ion binding]; other site 695562002269 putative protofilament interaction site [polypeptide binding]; other site 695562002270 RodZ interaction site [polypeptide binding]; other site 695562002271 hypothetical protein; Provisional; Region: PRK14379 695562002272 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 695562002273 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 695562002274 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 695562002275 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 695562002276 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 695562002277 Ligand Binding Site [chemical binding]; other site 695562002278 recombination factor protein RarA; Reviewed; Region: PRK13342 695562002279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 695562002280 Walker A motif; other site 695562002281 ATP binding site [chemical binding]; other site 695562002282 Walker B motif; other site 695562002283 arginine finger; other site 695562002284 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 695562002285 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 695562002286 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 695562002287 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 695562002288 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 695562002289 RNA binding surface [nucleotide binding]; other site 695562002290 septation ring formation regulator EzrA; Provisional; Region: PRK04778 695562002291 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 695562002292 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 695562002293 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 695562002294 catalytic residue [active] 695562002295 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 695562002296 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 695562002297 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 695562002298 Ligand Binding Site [chemical binding]; other site 695562002299 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 695562002300 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 695562002301 non-specific DNA binding site [nucleotide binding]; other site 695562002302 salt bridge; other site 695562002303 sequence-specific DNA binding site [nucleotide binding]; other site 695562002304 Transposase, Mutator family; Region: Transposase_mut; pfam00872 695562002305 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 695562002306 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 695562002307 RNA binding surface [nucleotide binding]; other site 695562002308 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 695562002309 active site 695562002310 uracil binding [chemical binding]; other site 695562002311 Predicted membrane protein [Function unknown]; Region: COG2246 695562002312 GtrA-like protein; Region: GtrA; pfam04138 695562002313 FMN-binding domain; Region: FMN_bind; pfam04205 695562002314 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 695562002315 L-aspartate oxidase; Provisional; Region: PRK06175 695562002316 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 695562002317 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 695562002318 active site 695562002319 HIGH motif; other site 695562002320 nucleotide binding site [chemical binding]; other site 695562002321 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 695562002322 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 695562002323 active site 695562002324 KMSKS motif; other site 695562002325 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 695562002326 tRNA binding surface [nucleotide binding]; other site 695562002327 anticodon binding site; other site 695562002328 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 695562002329 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 695562002330 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 695562002331 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 695562002332 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 695562002333 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 695562002334 motif II; other site 695562002335 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 695562002336 MPN+ (JAMM) motif; other site 695562002337 Zinc-binding site [ion binding]; other site 695562002338 rod shape-determining protein MreB; Provisional; Region: PRK13927 695562002339 MreB and similar proteins; Region: MreB_like; cd10225 695562002340 nucleotide binding site [chemical binding]; other site 695562002341 Mg binding site [ion binding]; other site 695562002342 putative protofilament interaction site [polypeptide binding]; other site 695562002343 RodZ interaction site [polypeptide binding]; other site 695562002344 rod shape-determining protein MreC; Provisional; Region: PRK13922 695562002345 rod shape-determining protein MreC; Region: MreC; pfam04085 695562002346 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 695562002347 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 695562002348 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 695562002349 cell division protein MraZ; Reviewed; Region: PRK00326 695562002350 MraZ protein; Region: MraZ; pfam02381 695562002351 MraZ protein; Region: MraZ; pfam02381 695562002352 MraW methylase family; Region: Methyltransf_5; pfam01795 695562002353 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 695562002354 Cell division protein FtsL; Region: FtsL; cl11433 695562002355 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 695562002356 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 695562002357 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 695562002358 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 695562002359 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 695562002360 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 695562002361 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 695562002362 Mg++ binding site [ion binding]; other site 695562002363 putative catalytic motif [active] 695562002364 putative substrate binding site [chemical binding]; other site 695562002365 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 695562002366 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 695562002367 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 695562002368 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 695562002369 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 695562002370 active site 695562002371 homodimer interface [polypeptide binding]; other site 695562002372 Cell division protein FtsQ; Region: FtsQ; pfam03799 695562002373 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 695562002374 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 695562002375 nucleotide binding site [chemical binding]; other site 695562002376 Cell division protein FtsA; Region: FtsA; cl17206 695562002377 Cell division protein FtsA; Region: FtsA; pfam14450 695562002378 cell division protein FtsZ; Validated; Region: PRK09330 695562002379 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 695562002380 nucleotide binding site [chemical binding]; other site 695562002381 SulA interaction site; other site 695562002382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 695562002383 YGGT family; Region: YGGT; pfam02325 695562002384 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 695562002385 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 695562002386 RNA binding surface [nucleotide binding]; other site 695562002387 DivIVA protein; Region: DivIVA; pfam05103 695562002388 DivIVA domain; Region: DivI1A_domain; TIGR03544 695562002389 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 695562002390 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 695562002391 active site 695562002392 HIGH motif; other site 695562002393 nucleotide binding site [chemical binding]; other site 695562002394 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 695562002395 active site 695562002396 KMSKS motif; other site 695562002397 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 695562002398 tRNA binding surface [nucleotide binding]; other site 695562002399 anticodon binding site; other site 695562002400 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 695562002401 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 695562002402 DNA-binding site [nucleotide binding]; DNA binding site 695562002403 RNA-binding motif; other site 695562002404 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 695562002405 dimer interface [polypeptide binding]; other site 695562002406 ADP-ribose binding site [chemical binding]; other site 695562002407 active site 695562002408 nudix motif; other site 695562002409 metal binding site [ion binding]; metal-binding site 695562002410 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 695562002411 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 695562002412 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 695562002413 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 695562002414 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 695562002415 catalytic residue [active] 695562002416 Putative amino acid metabolism; Region: DUF1831; pfam08866 695562002417 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 695562002418 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 695562002419 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 695562002420 catalytic core [active] 695562002421 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 695562002422 binding surface 695562002423 TPR motif; other site 695562002424 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 695562002425 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 695562002426 AAA domain; Region: AAA_30; pfam13604 695562002427 Family description; Region: UvrD_C_2; pfam13538 695562002428 Nuclease-related domain; Region: NERD; pfam08378 695562002429 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 695562002430 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 695562002431 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 695562002432 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 695562002433 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 695562002434 hypothetical protein; Provisional; Region: PRK13667 695562002435 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 695562002436 active site 695562002437 catalytic residues [active] 695562002438 metal binding site [ion binding]; metal-binding site 695562002439 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 695562002440 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 695562002441 G1 box; other site 695562002442 putative GEF interaction site [polypeptide binding]; other site 695562002443 GTP/Mg2+ binding site [chemical binding]; other site 695562002444 Switch I region; other site 695562002445 G2 box; other site 695562002446 G3 box; other site 695562002447 Switch II region; other site 695562002448 G4 box; other site 695562002449 G5 box; other site 695562002450 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 695562002451 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 695562002452 cell division protein FtsW; Region: ftsW; TIGR02614 695562002453 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 695562002454 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 695562002455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 695562002456 S-adenosylmethionine binding site [chemical binding]; other site 695562002457 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 695562002458 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 695562002459 active site 695562002460 (T/H)XGH motif; other site 695562002461 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 695562002462 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 695562002463 SLBB domain; Region: SLBB; pfam10531 695562002464 comEA protein; Region: comE; TIGR01259 695562002465 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 695562002466 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 695562002467 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 695562002468 Competence protein; Region: Competence; pfam03772 695562002469 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 695562002470 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 695562002471 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 695562002472 DNA polymerase III, delta subunit; Region: holA; TIGR01128 695562002473 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 695562002474 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 695562002475 16S/18S rRNA binding site [nucleotide binding]; other site 695562002476 S13e-L30e interaction site [polypeptide binding]; other site 695562002477 25S rRNA binding site [nucleotide binding]; other site 695562002478 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 695562002479 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 695562002480 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 695562002481 elongation factor Tu; Reviewed; Region: PRK00049 695562002482 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 695562002483 G1 box; other site 695562002484 GEF interaction site [polypeptide binding]; other site 695562002485 GTP/Mg2+ binding site [chemical binding]; other site 695562002486 Switch I region; other site 695562002487 G2 box; other site 695562002488 G3 box; other site 695562002489 Switch II region; other site 695562002490 G4 box; other site 695562002491 G5 box; other site 695562002492 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 695562002493 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 695562002494 Antibiotic Binding Site [chemical binding]; other site 695562002495 trigger factor; Provisional; Region: tig; PRK01490 695562002496 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 695562002497 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 695562002498 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 695562002499 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 695562002500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 695562002501 Walker A motif; other site 695562002502 ATP binding site [chemical binding]; other site 695562002503 Walker B motif; other site 695562002504 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 695562002505 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 695562002506 G1 box; other site 695562002507 GTP/Mg2+ binding site [chemical binding]; other site 695562002508 Switch I region; other site 695562002509 G2 box; other site 695562002510 G3 box; other site 695562002511 Switch II region; other site 695562002512 G4 box; other site 695562002513 G5 box; other site 695562002514 potential frameshift: common BLAST hit: gi|325956544|ref|YP_004291956.1| inner membrane transporter YjeM 695562002515 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 695562002516 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 695562002517 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 695562002518 aspartate kinase; Reviewed; Region: PRK09034 695562002519 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 695562002520 putative catalytic residues [active] 695562002521 putative nucleotide binding site [chemical binding]; other site 695562002522 putative aspartate binding site [chemical binding]; other site 695562002523 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 695562002524 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 695562002525 diaminopimelate decarboxylase; Region: lysA; TIGR01048 695562002526 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 695562002527 active site 695562002528 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 695562002529 substrate binding site [chemical binding]; other site 695562002530 catalytic residues [active] 695562002531 dimer interface [polypeptide binding]; other site 695562002532 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 695562002533 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 695562002534 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 695562002535 active site 695562002536 trimer interface [polypeptide binding]; other site 695562002537 substrate binding site [chemical binding]; other site 695562002538 CoA binding site [chemical binding]; other site 695562002539 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 695562002540 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 695562002541 metal binding site [ion binding]; metal-binding site 695562002542 putative dimer interface [polypeptide binding]; other site 695562002543 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 695562002544 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 695562002545 dimer interface [polypeptide binding]; other site 695562002546 active site 695562002547 catalytic residue [active] 695562002548 dihydrodipicolinate reductase; Provisional; Region: PRK00048 695562002549 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 695562002550 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 695562002551 aromatic amino acid aminotransferase; Validated; Region: PRK07309 695562002552 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 695562002553 pyridoxal 5'-phosphate binding site [chemical binding]; other site 695562002554 homodimer interface [polypeptide binding]; other site 695562002555 catalytic residue [active] 695562002556 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 695562002557 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 695562002558 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 695562002559 Beta-lactamase; Region: Beta-lactamase; pfam00144 695562002560 potential frameshift: common BLAST hit: gi|58336922|ref|YP_193507.1| multidrug resistance ABC transporter ATP binding protein 695562002561 potential frameshift: common BLAST hit: gi|42519083|ref|NP_965013.1| ABC transporter ATPase and permease components 695562002562 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 695562002563 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 695562002564 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 695562002565 FMN-binding domain; Region: FMN_bind; cl01081 695562002566 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 695562002567 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 695562002568 nudix motif; other site 695562002569 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 695562002570 active site 695562002571 dimerization interface [polypeptide binding]; other site 695562002572 potential frameshift: common BLAST hit: gi|336054292|ref|YP_004562579.1| AraC family transcriptional regulator 695562002573 Helix-turn-helix domain; Region: HTH_18; pfam12833 695562002574 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 695562002575 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 695562002576 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 695562002577 beta-galactosidase; Region: BGL; TIGR03356 695562002578 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 695562002579 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 695562002580 DNA-binding site [nucleotide binding]; DNA binding site 695562002581 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 695562002582 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 695562002583 active site 695562002584 P-loop; other site 695562002585 phosphorylation site [posttranslational modification] 695562002586 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 695562002587 active site 695562002588 methionine cluster; other site 695562002589 phosphorylation site [posttranslational modification] 695562002590 metal binding site [ion binding]; metal-binding site 695562002591 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 695562002592 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 695562002593 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 695562002594 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 695562002595 potential frameshift: common BLAST hit: gi|161508229|ref|YP_001576727.1| transposase ORF_C 695562002596 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 695562002597 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 695562002598 beta-galactosidase; Region: BGL; TIGR03356 695562002599 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 695562002600 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 695562002601 DNA-binding site [nucleotide binding]; DNA binding site 695562002602 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 695562002603 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 695562002604 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 695562002605 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 695562002606 beta-galactosidase; Region: BGL; TIGR03356 695562002607 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 695562002608 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 695562002609 nucleotide binding site [chemical binding]; other site 695562002610 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 695562002611 FMN binding site [chemical binding]; other site 695562002612 dimer interface [polypeptide binding]; other site 695562002613 enolase; Provisional; Region: eno; PRK00077 695562002614 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 695562002615 dimer interface [polypeptide binding]; other site 695562002616 metal binding site [ion binding]; metal-binding site 695562002617 substrate binding pocket [chemical binding]; other site 695562002618 EDD domain protein, DegV family; Region: DegV; TIGR00762 695562002619 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 695562002620 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 695562002621 active site 695562002622 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 695562002623 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 695562002624 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 695562002625 active site 695562002626 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 695562002627 thymidylate synthase; Region: thym_sym; TIGR03284 695562002628 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 695562002629 dimerization interface [polypeptide binding]; other site 695562002630 active site 695562002631 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 695562002632 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 695562002633 folate binding site [chemical binding]; other site 695562002634 NADP+ binding site [chemical binding]; other site 695562002635 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 695562002636 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 695562002637 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 695562002638 motif I; other site 695562002639 motif II; other site 695562002640 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 695562002641 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 695562002642 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 695562002643 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 695562002644 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 695562002645 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 695562002646 Walker A/P-loop; other site 695562002647 ATP binding site [chemical binding]; other site 695562002648 Q-loop/lid; other site 695562002649 ABC transporter signature motif; other site 695562002650 Walker B; other site 695562002651 D-loop; other site 695562002652 H-loop/switch region; other site 695562002653 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 695562002654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 695562002655 dimer interface [polypeptide binding]; other site 695562002656 conserved gate region; other site 695562002657 ABC-ATPase subunit interface; other site 695562002658 fumarate hydratase; Reviewed; Region: fumC; PRK00485 695562002659 Class II fumarases; Region: Fumarase_classII; cd01362 695562002660 active site 695562002661 tetramer interface [polypeptide binding]; other site 695562002662 L-aspartate oxidase; Provisional; Region: PRK06175 695562002663 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 695562002664 Predicted oxidoreductase [General function prediction only]; Region: COG3573 695562002665 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 695562002666 Glucan-binding protein C; Region: GbpC; pfam08363 695562002667 MucBP domain; Region: MucBP; pfam06458 695562002668 MucBP domain; Region: MucBP; pfam06458 695562002669 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 695562002670 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 695562002671 tetramer (dimer of dimers) interface [polypeptide binding]; other site 695562002672 NAD binding site [chemical binding]; other site 695562002673 dimer interface [polypeptide binding]; other site 695562002674 substrate binding site [chemical binding]; other site 695562002675 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 695562002676 trimer interface [polypeptide binding]; other site 695562002677 active site 695562002678 G bulge; other site 695562002679 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 695562002680 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 695562002681 Integrase core domain; Region: rve; pfam00665 695562002682 potential frameshift: common BLAST hit: gi|161507403|ref|YP_001577357.1| 2-oxoglutarate-malate translocator 695562002683 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 695562002684 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 695562002685 active site 695562002686 HIGH motif; other site 695562002687 nucleotide binding site [chemical binding]; other site 695562002688 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 695562002689 Protein of unknown function (DUF441); Region: DUF441; pfam04284 695562002690 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 695562002691 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 695562002692 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 695562002693 Walker A/P-loop; other site 695562002694 ATP binding site [chemical binding]; other site 695562002695 Q-loop/lid; other site 695562002696 ABC transporter signature motif; other site 695562002697 Walker B; other site 695562002698 D-loop; other site 695562002699 H-loop/switch region; other site 695562002700 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 695562002701 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 695562002702 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 695562002703 Walker A/P-loop; other site 695562002704 ATP binding site [chemical binding]; other site 695562002705 Q-loop/lid; other site 695562002706 ABC transporter signature motif; other site 695562002707 Walker B; other site 695562002708 D-loop; other site 695562002709 H-loop/switch region; other site 695562002710 hypothetical protein; Provisional; Region: PRK13661 695562002711 potential frameshift: common BLAST hit: gi|315038157|ref|YP_004031725.1| thiamine biosynthesis lipoprotein 695562002712 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 695562002713 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 695562002714 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 695562002715 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 695562002716 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 695562002717 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 695562002718 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 695562002719 putative deacylase active site [active] 695562002720 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 695562002721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 695562002722 S-adenosylmethionine binding site [chemical binding]; other site 695562002723 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 695562002724 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 695562002725 Zn2+ binding site [ion binding]; other site 695562002726 Mg2+ binding site [ion binding]; other site 695562002727 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 695562002728 synthetase active site [active] 695562002729 NTP binding site [chemical binding]; other site 695562002730 metal binding site [ion binding]; metal-binding site 695562002731 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 695562002732 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 695562002733 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 695562002734 putative active site [active] 695562002735 dimerization interface [polypeptide binding]; other site 695562002736 putative tRNAtyr binding site [nucleotide binding]; other site 695562002737 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 695562002738 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 695562002739 dimer interface [polypeptide binding]; other site 695562002740 motif 1; other site 695562002741 active site 695562002742 motif 2; other site 695562002743 motif 3; other site 695562002744 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 695562002745 anticodon binding site; other site 695562002746 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 695562002747 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 695562002748 dimer interface [polypeptide binding]; other site 695562002749 anticodon binding site; other site 695562002750 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 695562002751 homodimer interface [polypeptide binding]; other site 695562002752 motif 1; other site 695562002753 active site 695562002754 motif 2; other site 695562002755 GAD domain; Region: GAD; pfam02938 695562002756 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 695562002757 active site 695562002758 motif 3; other site 695562002759 aromatic amino acid aminotransferase; Validated; Region: PRK07309 695562002760 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 695562002761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 695562002762 homodimer interface [polypeptide binding]; other site 695562002763 catalytic residue [active] 695562002764 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 695562002765 Flavoprotein; Region: Flavoprotein; pfam02441 695562002766 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 695562002767 potential frameshift: common BLAST hit: gi|295692853|ref|YP_003601463.1| oxidoreductase, aldo/keto reductase family protein 695562002768 potential frameshift: common BLAST hit: gi|295692853|ref|YP_003601463.1| oxidoreductase, aldo/keto reductase family protein 695562002769 sugar phosphate phosphatase; Provisional; Region: PRK10513 695562002770 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 695562002771 active site 695562002772 motif I; other site 695562002773 motif II; other site 695562002774 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 695562002775 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 695562002776 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 695562002777 putative ligand binding site [chemical binding]; other site 695562002778 putative NAD binding site [chemical binding]; other site 695562002779 catalytic site [active] 695562002780 amino acid transporter; Region: 2A0306; TIGR00909 695562002781 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 695562002782 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 695562002783 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 695562002784 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 695562002785 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 695562002786 GIY-YIG motif/motif A; other site 695562002787 active site 695562002788 catalytic site [active] 695562002789 putative DNA binding site [nucleotide binding]; other site 695562002790 metal binding site [ion binding]; metal-binding site 695562002791 UvrB/uvrC motif; Region: UVR; pfam02151 695562002792 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 695562002793 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 695562002794 DNA binding site [nucleotide binding] 695562002795 GTPase CgtA; Reviewed; Region: obgE; PRK12297 695562002796 GTP1/OBG; Region: GTP1_OBG; pfam01018 695562002797 Obg GTPase; Region: Obg; cd01898 695562002798 G1 box; other site 695562002799 GTP/Mg2+ binding site [chemical binding]; other site 695562002800 Switch I region; other site 695562002801 G2 box; other site 695562002802 G3 box; other site 695562002803 Switch II region; other site 695562002804 G4 box; other site 695562002805 G5 box; other site 695562002806 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 695562002807 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 695562002808 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 695562002809 catalytic triad [active] 695562002810 catalytic triad [active] 695562002811 oxyanion hole [active] 695562002812 ribonuclease Z; Region: RNase_Z; TIGR02651 695562002813 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 695562002814 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 695562002815 NAD(P) binding site [chemical binding]; other site 695562002816 active site 695562002817 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 695562002818 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 695562002819 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 695562002820 active site 695562002821 metal binding site [ion binding]; metal-binding site 695562002822 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 695562002823 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 695562002824 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 695562002825 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 695562002826 active site 695562002827 PHP Thumb interface [polypeptide binding]; other site 695562002828 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 695562002829 generic binding surface I; other site 695562002830 generic binding surface II; other site 695562002831 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 695562002832 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 695562002833 active site 695562002834 ADP/pyrophosphate binding site [chemical binding]; other site 695562002835 dimerization interface [polypeptide binding]; other site 695562002836 allosteric effector site; other site 695562002837 fructose-1,6-bisphosphate binding site; other site 695562002838 pyruvate kinase; Provisional; Region: PRK06354 695562002839 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 695562002840 domain interfaces; other site 695562002841 active site 695562002842 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 695562002843 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 695562002844 S1 domain; Region: S1_2; pfam13509 695562002845 MarR family; Region: MarR_2; pfam12802 695562002846 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 695562002847 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 695562002848 active site 695562002849 Int/Topo IB signature motif; other site 695562002850 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 695562002851 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 695562002852 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 695562002853 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 695562002854 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 695562002855 RNA binding surface [nucleotide binding]; other site 695562002856 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 695562002857 active site 695562002858 Predicted membrane protein [Function unknown]; Region: COG3601 695562002859 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 695562002860 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 695562002861 cytidylate kinase; Provisional; Region: cmk; PRK00023 695562002862 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 695562002863 CMP-binding site; other site 695562002864 The sites determining sugar specificity; other site 695562002865 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 695562002866 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 695562002867 RNA binding site [nucleotide binding]; other site 695562002868 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 695562002869 RNA binding site [nucleotide binding]; other site 695562002870 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 695562002871 RNA binding site [nucleotide binding]; other site 695562002872 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 695562002873 RNA binding site [nucleotide binding]; other site 695562002874 GTP-binding protein Der; Reviewed; Region: PRK00093 695562002875 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 695562002876 G1 box; other site 695562002877 GTP/Mg2+ binding site [chemical binding]; other site 695562002878 Switch I region; other site 695562002879 G2 box; other site 695562002880 Switch II region; other site 695562002881 G3 box; other site 695562002882 G4 box; other site 695562002883 G5 box; other site 695562002884 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 695562002885 G1 box; other site 695562002886 GTP/Mg2+ binding site [chemical binding]; other site 695562002887 Switch I region; other site 695562002888 G2 box; other site 695562002889 G3 box; other site 695562002890 Switch II region; other site 695562002891 G4 box; other site 695562002892 G5 box; other site 695562002893 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 695562002894 IHF dimer interface [polypeptide binding]; other site 695562002895 IHF - DNA interface [nucleotide binding]; other site 695562002896 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 695562002897 TPR motif; other site 695562002898 binding surface 695562002899 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 695562002900 binding surface 695562002901 TPR motif; other site 695562002902 Uncharacterized conserved protein [Function unknown]; Region: COG1284 695562002903 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 695562002904 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 695562002905 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 695562002906 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 695562002907 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 695562002908 active site 695562002909 NTP binding site [chemical binding]; other site 695562002910 metal binding triad [ion binding]; metal-binding site 695562002911 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 695562002912 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 695562002913 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 695562002914 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 695562002915 EDD domain protein, DegV family; Region: DegV; TIGR00762 695562002916 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 695562002917 hypothetical protein; Provisional; Region: PRK13672 695562002918 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 695562002919 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 695562002920 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 695562002921 GTP/Mg2+ binding site [chemical binding]; other site 695562002922 G4 box; other site 695562002923 G5 box; other site 695562002924 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 695562002925 G1 box; other site 695562002926 G1 box; other site 695562002927 GTP/Mg2+ binding site [chemical binding]; other site 695562002928 Switch I region; other site 695562002929 G2 box; other site 695562002930 G2 box; other site 695562002931 G3 box; other site 695562002932 G3 box; other site 695562002933 Switch II region; other site 695562002934 Switch II region; other site 695562002935 G4 box; other site 695562002936 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 695562002937 RNA/DNA hybrid binding site [nucleotide binding]; other site 695562002938 active site 695562002939 DNA protecting protein DprA; Region: dprA; TIGR00732 695562002940 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 695562002941 DNA topoisomerase I; Validated; Region: PRK05582 695562002942 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 695562002943 active site 695562002944 interdomain interaction site; other site 695562002945 putative metal-binding site [ion binding]; other site 695562002946 nucleotide binding site [chemical binding]; other site 695562002947 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 695562002948 domain I; other site 695562002949 DNA binding groove [nucleotide binding] 695562002950 phosphate binding site [ion binding]; other site 695562002951 domain II; other site 695562002952 domain III; other site 695562002953 nucleotide binding site [chemical binding]; other site 695562002954 catalytic site [active] 695562002955 domain IV; other site 695562002956 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 695562002957 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 695562002958 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 695562002959 Glucose inhibited division protein A; Region: GIDA; pfam01134 695562002960 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 695562002961 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 695562002962 active site 695562002963 DNA binding site [nucleotide binding] 695562002964 Int/Topo IB signature motif; other site 695562002965 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 695562002966 active site 695562002967 HslU subunit interaction site [polypeptide binding]; other site 695562002968 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 695562002969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 695562002970 Walker A motif; other site 695562002971 ATP binding site [chemical binding]; other site 695562002972 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 695562002973 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 695562002974 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 695562002975 active site 695562002976 catalytic residues [active] 695562002977 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 695562002978 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 695562002979 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 695562002980 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 695562002981 camphor resistance protein CrcB; Provisional; Region: PRK14220 695562002982 dipeptidase PepV; Reviewed; Region: PRK07318 695562002983 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 695562002984 active site 695562002985 metal binding site [ion binding]; metal-binding site 695562002986 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 695562002987 Amino acid permease; Region: AA_permease_2; pfam13520 695562002988 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 695562002989 putative ornithine decarboxylase; Region: lacto_ODC_hypo; TIGR04318 695562002990 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 695562002991 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 695562002992 catalytic residue [active] 695562002993 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 695562002994 Aluminium resistance protein; Region: Alum_res; pfam06838 695562002995 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 695562002996 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 695562002997 TrkA-N domain; Region: TrkA_N; pfam02254 695562002998 TrkA-C domain; Region: TrkA_C; pfam02080 695562002999 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 695562003000 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 695562003001 potential frameshift: common BLAST hit: gi|325956686|ref|YP_004292098.1| ATP-dependent DNA helicase RecQ 695562003002 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 695562003003 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 695562003004 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 695562003005 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 695562003006 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 695562003007 active site 695562003008 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 695562003009 Beta-lactamase; Region: Beta-lactamase; pfam00144 695562003010 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 695562003011 pyridoxal binding site [chemical binding]; other site 695562003012 dimer interface [polypeptide binding]; other site 695562003013 ATP binding site [chemical binding]; other site 695562003014 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 695562003015 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 695562003016 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 695562003017 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 695562003018 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 695562003019 inner membrane transporter YjeM; Provisional; Region: PRK15238 695562003020 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 695562003021 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 695562003022 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 695562003023 Walker A motif; other site 695562003024 ATP binding site [chemical binding]; other site 695562003025 Walker B motif; other site 695562003026 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 695562003027 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 695562003028 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 695562003029 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 695562003030 putative acyl-acceptor binding pocket; other site 695562003031 helicase Cas3; Provisional; Region: PRK09694 695562003032 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 695562003033 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 695562003034 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 695562003035 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 695562003036 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 695562003037 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 695562003038 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 695562003039 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 695562003040 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 695562003041 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 695562003042 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 695562003043 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 695562003044 active site 695562003045 catalytic site [active] 695562003046 substrate binding site [chemical binding]; other site 695562003047 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 695562003048 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 695562003049 S-methylmethionine transporter; Provisional; Region: PRK11387 695562003050 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 695562003051 potential frameshift: common BLAST hit: gi|295692566|ref|YP_003601176.1| amino acid permease 695562003052 potential frameshift: common BLAST hit: gi|116629939|ref|YP_815111.1| amino acid transporter 695562003053 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 695562003054 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 695562003055 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 695562003056 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 695562003057 dimer interface [polypeptide binding]; other site 695562003058 FMN binding site [chemical binding]; other site 695562003059 AAA domain; Region: AAA_33; pfam13671 695562003060 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 695562003061 Walker A/P-loop; other site 695562003062 ATP binding site [chemical binding]; other site 695562003063 Q-loop/lid; other site 695562003064 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 695562003065 Interdomain contacts; other site 695562003066 Cytokine receptor motif; other site 695562003067 potential frameshift: common BLAST hit: gi|257125194|ref|YP_003163308.1| protein of unknown function DUF262 695562003068 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 695562003069 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 695562003070 Transcriptional regulator [Transcription]; Region: LysR; COG0583 695562003071 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 695562003072 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 695562003073 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 695562003074 dimer interface [polypeptide binding]; other site 695562003075 FMN binding site [chemical binding]; other site 695562003076 hypothetical protein; Provisional; Region: PRK06194 695562003077 classical (c) SDRs; Region: SDR_c; cd05233 695562003078 NAD(P) binding site [chemical binding]; other site 695562003079 active site 695562003080 TIGR02687 family protein; Region: TIGR02687 695562003081 PglZ domain; Region: PglZ; pfam08665 695562003082 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 695562003083 Integrase core domain; Region: rve; pfam00665 695562003084 Integrase core domain; Region: rve_2; pfam13333 695562003085 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 695562003086 putative active site [active] 695562003087 potential frameshift: common BLAST hit: gi|116332909|ref|YP_794436.1| periplasmic protease 695562003088 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 695562003089 substrate binding site [chemical binding]; other site 695562003090 THF binding site; other site 695562003091 zinc-binding site [ion binding]; other site 695562003092 S-ribosylhomocysteinase; Provisional; Region: PRK02260 695562003093 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 695562003094 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 695562003095 active site 695562003096 motif I; other site 695562003097 motif II; other site 695562003098 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 695562003099 benzoate transport; Region: 2A0115; TIGR00895 695562003100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 695562003101 putative substrate translocation pore; other site 695562003102 Predicted membrane protein [Function unknown]; Region: COG1288 695562003103 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 695562003104 Uncharacterized conserved protein [Function unknown]; Region: COG1359 695562003105 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 695562003106 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 695562003107 Coenzyme A binding pocket [chemical binding]; other site 695562003108 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 695562003109 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 695562003110 active site 695562003111 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 695562003112 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 695562003113 polyphosphate kinase; Provisional; Region: PRK05443 695562003114 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 695562003115 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 695562003116 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 695562003117 putative domain interface [polypeptide binding]; other site 695562003118 putative active site [active] 695562003119 catalytic site [active] 695562003120 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 695562003121 putative domain interface [polypeptide binding]; other site 695562003122 putative active site [active] 695562003123 catalytic site [active] 695562003124 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 695562003125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 695562003126 exopolyphosphatase; Region: exo_poly_only; TIGR03706 695562003127 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 695562003128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 695562003129 NADH(P)-binding; Region: NAD_binding_10; pfam13460 695562003130 NAD(P) binding site [chemical binding]; other site 695562003131 active site 695562003132 potential frameshift: common BLAST hit: gi|58337318|ref|YP_193903.1| oxidoreductase 695562003133 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 695562003134 homopentamer interface [polypeptide binding]; other site 695562003135 active site 695562003136 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 695562003137 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 695562003138 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 695562003139 dimerization interface [polypeptide binding]; other site 695562003140 DPS ferroxidase diiron center [ion binding]; other site 695562003141 ion pore; other site 695562003142 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 695562003143 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 695562003144 active site 695562003145 catalytic tetrad [active] 695562003146 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 695562003147 Abi-like protein; Region: Abi_2; cl01988 695562003148 multicopper oxidase; Provisional; Region: PRK10965 695562003149 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 695562003150 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 695562003151 RelB antitoxin; Region: RelB; cl01171 695562003152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 695562003153 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 695562003154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 695562003155 ABC transporter signature motif; other site 695562003156 Walker B; other site 695562003157 D-loop; other site 695562003158 H-loop/switch region; other site 695562003159 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 695562003160 membrane-bound complex binding site; other site 695562003161 hinge residues; other site 695562003162 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 695562003163 catalytic core [active] 695562003164 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 695562003165 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 695562003166 catalytic triad [active] 695562003167 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 695562003168 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 695562003169 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 695562003170 nudix motif; other site 695562003171 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 695562003172 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 695562003173 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 695562003174 putative CoA binding site [chemical binding]; other site 695562003175 putative trimer interface [polypeptide binding]; other site 695562003176 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 695562003177 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 695562003178 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 695562003179 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 695562003180 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 695562003181 active site 695562003182 metal binding site [ion binding]; metal-binding site 695562003183 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 695562003184 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 695562003185 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 695562003186 putative active site [active] 695562003187 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 695562003188 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 695562003189 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 695562003190 catalytic core [active] 695562003191 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 695562003192 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 695562003193 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 695562003194 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 695562003195 active site 695562003196 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 695562003197 MarR family; Region: MarR_2; pfam12802 695562003198 potential frameshift: common BLAST hit: gi|116630050|ref|YP_815222.1| major facilitator superfamily permease 695562003199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 695562003200 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 695562003201 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 695562003202 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 695562003203 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 695562003204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 695562003205 Walker A/P-loop; other site 695562003206 ATP binding site [chemical binding]; other site 695562003207 Q-loop/lid; other site 695562003208 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 695562003209 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 695562003210 ABC transporter signature motif; other site 695562003211 Walker B; other site 695562003212 D-loop; other site 695562003213 H-loop/switch region; other site 695562003214 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 695562003215 AAA domain; Region: AAA_21; pfam13304 695562003216 Walker A/P-loop; other site 695562003217 ATP binding site [chemical binding]; other site 695562003218 Q-loop/lid; other site 695562003219 ABC transporter signature motif; other site 695562003220 Walker B; other site 695562003221 D-loop; other site 695562003222 H-loop/switch region; other site 695562003223 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 695562003224 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 695562003225 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 695562003226 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 695562003227 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 695562003228 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 695562003229 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 695562003230 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 695562003231 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 695562003232 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 695562003233 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 695562003234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 695562003235 Amino acid permease; Region: AA_permease_2; pfam13520 695562003236 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 695562003237 minor groove reading motif; other site 695562003238 helix-hairpin-helix signature motif; other site 695562003239 active site 695562003240 Predicted membrane protein [Function unknown]; Region: COG2855 695562003241 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 695562003242 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 695562003243 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 695562003244 ATP binding site [chemical binding]; other site 695562003245 putative Mg++ binding site [ion binding]; other site 695562003246 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 695562003247 nucleotide binding region [chemical binding]; other site 695562003248 ATP-binding site [chemical binding]; other site 695562003249 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 695562003250 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 695562003251 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 695562003252 Mg2+ binding site [ion binding]; other site 695562003253 G-X-G motif; other site 695562003254 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 695562003255 anchoring element; other site 695562003256 dimer interface [polypeptide binding]; other site 695562003257 ATP binding site [chemical binding]; other site 695562003258 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 695562003259 active site 695562003260 putative metal-binding site [ion binding]; other site 695562003261 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 695562003262 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 695562003263 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 695562003264 CAP-like domain; other site 695562003265 active site 695562003266 primary dimer interface [polypeptide binding]; other site 695562003267 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 695562003268 Transcriptional regulator [Transcription]; Region: LysR; COG0583 695562003269 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 695562003270 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 695562003271 dimerization interface [polypeptide binding]; other site 695562003272 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 695562003273 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 695562003274 DHHA2 domain; Region: DHHA2; pfam02833 695562003275 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 695562003276 active site 695562003277 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 695562003278 non-specific DNA binding site [nucleotide binding]; other site 695562003279 salt bridge; other site 695562003280 sequence-specific DNA binding site [nucleotide binding]; other site 695562003281 potential frameshift: common BLAST hit: gi|161508078|ref|YP_001578045.1| transposase 695562003282 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 695562003283 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 695562003284 SnoaL-like domain; Region: SnoaL_2; pfam12680 695562003285 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 695562003286 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 695562003287 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 695562003288 Fic/DOC family; Region: Fic; pfam02661 695562003289 Fic/DOC family; Region: Fic; cl00960 695562003290 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 695562003291 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 695562003292 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 695562003293 Walker A/P-loop; other site 695562003294 ATP binding site [chemical binding]; other site 695562003295 Q-loop/lid; other site 695562003296 ABC transporter signature motif; other site 695562003297 Walker B; other site 695562003298 D-loop; other site 695562003299 H-loop/switch region; other site 695562003300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 695562003301 Walker A/P-loop; other site 695562003302 ATP binding site [chemical binding]; other site 695562003303 ABC transporter; Region: ABC_tran; pfam00005 695562003304 Q-loop/lid; other site 695562003305 ABC transporter signature motif; other site 695562003306 Walker B; other site 695562003307 D-loop; other site 695562003308 H+ Antiporter protein; Region: 2A0121; TIGR00900 695562003309 LytTr DNA-binding domain; Region: LytTR; smart00850 695562003310 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 695562003311 potential frameshift: common BLAST hit: gi|295693382|ref|YP_003601992.1| ABC transporter, ATP-binding protein 695562003312 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 695562003313 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 695562003314 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 695562003315 active site 695562003316 Bacterial surface layer protein; Region: SLAP; pfam03217 695562003317 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 695562003318 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 695562003319 active site 695562003320 DNA binding site [nucleotide binding] 695562003321 Int/Topo IB signature motif; other site 695562003322 EDD domain protein, DegV family; Region: DegV; TIGR00762 695562003323 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 695562003324 Transcriptional regulators [Transcription]; Region: MarR; COG1846 695562003325 MarR family; Region: MarR_2; pfam12802 695562003326 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 695562003327 Domain of unknown function (DUF814); Region: DUF814; pfam05670 695562003328 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 695562003329 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 695562003330 ATP-grasp domain; Region: ATP-grasp_4; cl17255 695562003331 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 695562003332 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 695562003333 ATP-grasp domain; Region: ATP-grasp_4; cl17255 695562003334 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 695562003335 IMP binding site; other site 695562003336 dimer interface [polypeptide binding]; other site 695562003337 interdomain contacts; other site 695562003338 partial ornithine binding site; other site 695562003339 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 695562003340 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 695562003341 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 695562003342 catalytic site [active] 695562003343 subunit interface [polypeptide binding]; other site 695562003344 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 695562003345 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 695562003346 RNA binding surface [nucleotide binding]; other site 695562003347 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 695562003348 active site 695562003349 lipoprotein signal peptidase; Provisional; Region: PRK14797 695562003350 lipoprotein signal peptidase; Provisional; Region: PRK14787 695562003351 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 695562003352 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 695562003353 Potassium binding sites [ion binding]; other site 695562003354 Cesium cation binding sites [ion binding]; other site 695562003355 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 695562003356 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 695562003357 active site 695562003358 metal binding site [ion binding]; metal-binding site 695562003359 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 695562003360 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 695562003361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 695562003362 DivIVA protein; Region: DivIVA; pfam05103 695562003363 DivIVA domain; Region: DivI1A_domain; TIGR03544 695562003364 hypothetical protein; Provisional; Region: PRK13660 695562003365 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 695562003366 Transglycosylase; Region: Transgly; pfam00912 695562003367 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 695562003368 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 695562003369 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 695562003370 endonuclease III; Region: ENDO3c; smart00478 695562003371 minor groove reading motif; other site 695562003372 helix-hairpin-helix signature motif; other site 695562003373 substrate binding pocket [chemical binding]; other site 695562003374 active site 695562003375 Helix-turn-helix domain; Region: HTH_36; pfam13730 695562003376 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 695562003377 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 695562003378 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 695562003379 putative dimer interface [polypeptide binding]; other site 695562003380 putative anticodon binding site; other site 695562003381 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 695562003382 homodimer interface [polypeptide binding]; other site 695562003383 motif 1; other site 695562003384 motif 2; other site 695562003385 active site 695562003386 motif 3; other site 695562003387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 695562003388 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 695562003389 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 695562003390 active site 695562003391 catalytic site [active] 695562003392 substrate binding site [chemical binding]; other site 695562003393 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 695562003394 ATP binding site [chemical binding]; other site 695562003395 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 695562003396 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 695562003397 Part of AAA domain; Region: AAA_19; pfam13245 695562003398 Family description; Region: UvrD_C_2; pfam13538 695562003399 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 695562003400 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 695562003401 mevalonate kinase; Region: mevalon_kin; TIGR00549 695562003402 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 695562003403 diphosphomevalonate decarboxylase; Region: PLN02407 695562003404 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 695562003405 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 695562003406 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 695562003407 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 695562003408 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 695562003409 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 695562003410 homotetramer interface [polypeptide binding]; other site 695562003411 FMN binding site [chemical binding]; other site 695562003412 homodimer contacts [polypeptide binding]; other site 695562003413 putative active site [active] 695562003414 putative substrate binding site [chemical binding]; other site 695562003415 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 695562003416 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 695562003417 active site 695562003418 motif I; other site 695562003419 motif II; other site 695562003420 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 695562003421 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 695562003422 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 695562003423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 695562003424 S-adenosylmethionine binding site [chemical binding]; other site 695562003425 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 695562003426 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 695562003427 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 695562003428 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 695562003429 Catalytic site [active] 695562003430 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 695562003431 Walker B motif; other site 695562003432 recombination factor protein RarA; Provisional; Region: PRK14700 695562003433 arginine finger; other site 695562003434 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 695562003435 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 695562003436 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 695562003437 Walker A/P-loop; other site 695562003438 ATP binding site [chemical binding]; other site 695562003439 Q-loop/lid; other site 695562003440 ABC transporter signature motif; other site 695562003441 Walker B; other site 695562003442 D-loop; other site 695562003443 H-loop/switch region; other site 695562003444 Predicted transcriptional regulators [Transcription]; Region: COG1725 695562003445 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 695562003446 DNA-binding site [nucleotide binding]; DNA binding site 695562003447 peptidase T; Region: peptidase-T; TIGR01882 695562003448 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 695562003449 metal binding site [ion binding]; metal-binding site 695562003450 dimer interface [polypeptide binding]; other site 695562003451 Uncharacterized conserved protein [Function unknown]; Region: COG0327 695562003452 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 695562003453 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 695562003454 Family of unknown function (DUF633); Region: DUF633; pfam04816 695562003455 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 695562003456 putative active site [active] 695562003457 nucleotide binding site [chemical binding]; other site 695562003458 nudix motif; other site 695562003459 putative metal binding site [ion binding]; other site 695562003460 Peptidase family M23; Region: Peptidase_M23; pfam01551 695562003461 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 695562003462 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 695562003463 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 695562003464 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 695562003465 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 695562003466 DNA binding residues [nucleotide binding] 695562003467 DNA primase; Validated; Region: dnaG; PRK05667 695562003468 CHC2 zinc finger; Region: zf-CHC2; cl17510 695562003469 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 695562003470 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 695562003471 active site 695562003472 metal binding site [ion binding]; metal-binding site 695562003473 interdomain interaction site; other site 695562003474 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 695562003475 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 695562003476 DALR anticodon binding domain; Region: DALR_1; pfam05746 695562003477 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 695562003478 motif 1; other site 695562003479 dimer interface [polypeptide binding]; other site 695562003480 active site 695562003481 motif 2; other site 695562003482 motif 3; other site 695562003483 Recombination protein O N terminal; Region: RecO_N; pfam11967 695562003484 DNA repair protein RecO; Region: reco; TIGR00613 695562003485 Recombination protein O C terminal; Region: RecO_C; pfam02565 695562003486 GTPase Era; Reviewed; Region: era; PRK00089 695562003487 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 695562003488 G1 box; other site 695562003489 GTP/Mg2+ binding site [chemical binding]; other site 695562003490 Switch I region; other site 695562003491 G2 box; other site 695562003492 Switch II region; other site 695562003493 G3 box; other site 695562003494 G4 box; other site 695562003495 G5 box; other site 695562003496 metal-binding heat shock protein; Provisional; Region: PRK00016 695562003497 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 695562003498 PhoH-like protein; Region: PhoH; pfam02562 695562003499 Yqey-like protein; Region: YqeY; pfam09424 695562003500 potential frameshift: common BLAST hit: gi|42519070|ref|NP_965000.1| manganese transport protein MntH2 695562003501 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 695562003502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 695562003503 Walker A/P-loop; other site 695562003504 ATP binding site [chemical binding]; other site 695562003505 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 695562003506 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 695562003507 Peptidase family M23; Region: Peptidase_M23; pfam01551 695562003508 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 695562003509 Uncharacterized conserved protein [Function unknown]; Region: COG1284 695562003510 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 695562003511 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 695562003512 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 695562003513 homoserine kinase; Provisional; Region: PRK01212 695562003514 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 695562003515 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 695562003516 potential frameshift: common BLAST hit: gi|58337494|ref|YP_194079.1| homoserine dehydrogenase Hdh 695562003517 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 695562003518 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 695562003519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 695562003520 catalytic residue [active] 695562003521 potential frameshift: common BLAST hit: gi|295693096|ref|YP_003601706.1| aspartokinase 695562003522 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 695562003523 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 695562003524 ligand binding site [chemical binding]; other site 695562003525 flexible hinge region; other site 695562003526 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 695562003527 putative switch regulator; other site 695562003528 non-specific DNA interactions [nucleotide binding]; other site 695562003529 DNA binding site [nucleotide binding] 695562003530 sequence specific DNA binding site [nucleotide binding]; other site 695562003531 putative cAMP binding site [chemical binding]; other site 695562003532 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 695562003533 metal-binding site [ion binding] 695562003534 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 695562003535 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 695562003536 Soluble P-type ATPase [General function prediction only]; Region: COG4087 695562003537 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 695562003538 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 695562003539 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 695562003540 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 695562003541 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 695562003542 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 695562003543 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 695562003544 dimerization interface [polypeptide binding]; other site 695562003545 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 695562003546 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 695562003547 Coenzyme A binding pocket [chemical binding]; other site 695562003548 potential frameshift: common BLAST hit: gi|295693108|ref|YP_003601718.1| apo-citrate lyase 695562003549 carbamate kinase; Reviewed; Region: PRK12686 695562003550 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 695562003551 putative substrate binding site [chemical binding]; other site 695562003552 nucleotide binding site [chemical binding]; other site 695562003553 nucleotide binding site [chemical binding]; other site 695562003554 homodimer interface [polypeptide binding]; other site 695562003555 ornithine carbamoyltransferase; Validated; Region: PRK02102 695562003556 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 695562003557 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 695562003558 arginine deiminase; Provisional; Region: PRK01388 695562003559 Transcriptional regulator [Transcription]; Region: LysR; COG0583 695562003560 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 695562003561 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 695562003562 dimerization interface [polypeptide binding]; other site 695562003563 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 695562003564 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 695562003565 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 695562003566 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 695562003567 Bacterial surface layer protein; Region: SLAP; pfam03217 695562003568 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 695562003569 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 695562003570 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 695562003571 putative active site [active] 695562003572 catalytic site [active] 695562003573 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 695562003574 putative active site [active] 695562003575 catalytic site [active] 695562003576 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 695562003577 conserved cys residue [active] 695562003578 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 695562003579 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 695562003580 dimer interface [polypeptide binding]; other site 695562003581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 695562003582 catalytic residue [active] 695562003583 Uncharacterized conserved protein [Function unknown]; Region: COG3589 695562003584 Uncharacterized conserved protein [Function unknown]; Region: COG3589 695562003585 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 695562003586 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 695562003587 Coenzyme A binding pocket [chemical binding]; other site 695562003588 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 695562003589 active site 695562003590 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 695562003591 DHH family; Region: DHH; pfam01368 695562003592 DHHA1 domain; Region: DHHA1; pfam02272 695562003593 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 695562003594 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 695562003595 active site 695562003596 catalytic site [active] 695562003597 GTP-binding protein LepA; Provisional; Region: PRK05433 695562003598 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 695562003599 G1 box; other site 695562003600 putative GEF interaction site [polypeptide binding]; other site 695562003601 GTP/Mg2+ binding site [chemical binding]; other site 695562003602 Switch I region; other site 695562003603 G2 box; other site 695562003604 G3 box; other site 695562003605 Switch II region; other site 695562003606 G4 box; other site 695562003607 G5 box; other site 695562003608 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 695562003609 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 695562003610 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 695562003611 chaperone protein DnaJ; Provisional; Region: PRK14276 695562003612 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 695562003613 HSP70 interaction site [polypeptide binding]; other site 695562003614 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 695562003615 substrate binding site [polypeptide binding]; other site 695562003616 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 695562003617 Zn binding sites [ion binding]; other site 695562003618 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 695562003619 dimer interface [polypeptide binding]; other site 695562003620 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 695562003621 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 695562003622 nucleotide binding site [chemical binding]; other site 695562003623 NEF interaction site [polypeptide binding]; other site 695562003624 SBD interface [polypeptide binding]; other site 695562003625 GrpE; Region: GrpE; pfam01025 695562003626 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 695562003627 dimer interface [polypeptide binding]; other site 695562003628 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 695562003629 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 695562003630 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 695562003631 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 695562003632 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 695562003633 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 695562003634 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 695562003635 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 695562003636 active site 695562003637 Riboflavin kinase; Region: Flavokinase; pfam01687 695562003638 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 695562003639 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 695562003640 RNA binding site [nucleotide binding]; other site 695562003641 active site 695562003642 Ribosome-binding factor A; Region: RBFA; cl00542 695562003643 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 695562003644 translation initiation factor IF-2; Validated; Region: infB; PRK05306 695562003645 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 695562003646 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 695562003647 G1 box; other site 695562003648 putative GEF interaction site [polypeptide binding]; other site 695562003649 GTP/Mg2+ binding site [chemical binding]; other site 695562003650 Switch I region; other site 695562003651 G2 box; other site 695562003652 G3 box; other site 695562003653 Switch II region; other site 695562003654 G4 box; other site 695562003655 G5 box; other site 695562003656 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 695562003657 Translation-initiation factor 2; Region: IF-2; pfam11987 695562003658 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 695562003659 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 695562003660 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 695562003661 putative RNA binding cleft [nucleotide binding]; other site 695562003662 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 695562003663 NusA N-terminal domain; Region: NusA_N; pfam08529 695562003664 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 695562003665 RNA binding site [nucleotide binding]; other site 695562003666 homodimer interface [polypeptide binding]; other site 695562003667 NusA-like KH domain; Region: KH_5; pfam13184 695562003668 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 695562003669 G-X-X-G motif; other site 695562003670 ribosome maturation protein RimP; Reviewed; Region: PRK00092 695562003671 Sm and related proteins; Region: Sm_like; cl00259 695562003672 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 695562003673 putative oligomer interface [polypeptide binding]; other site 695562003674 putative RNA binding site [nucleotide binding]; other site 695562003675 DNA polymerase III PolC; Validated; Region: polC; PRK00448 695562003676 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 695562003677 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 695562003678 generic binding surface II; other site 695562003679 generic binding surface I; other site 695562003680 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 695562003681 active site 695562003682 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 695562003683 active site 695562003684 catalytic site [active] 695562003685 substrate binding site [chemical binding]; other site 695562003686 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 695562003687 prolyl-tRNA synthetase; Provisional; Region: PRK09194 695562003688 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 695562003689 dimer interface [polypeptide binding]; other site 695562003690 motif 1; other site 695562003691 active site 695562003692 motif 2; other site 695562003693 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 695562003694 putative deacylase active site [active] 695562003695 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 695562003696 active site 695562003697 motif 3; other site 695562003698 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 695562003699 anticodon binding site; other site 695562003700 RIP metalloprotease RseP; Region: TIGR00054 695562003701 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 695562003702 active site 695562003703 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 695562003704 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 695562003705 protein binding site [polypeptide binding]; other site 695562003706 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 695562003707 putative substrate binding region [chemical binding]; other site 695562003708 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 695562003709 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 695562003710 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 695562003711 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 695562003712 catalytic residue [active] 695562003713 putative FPP diphosphate binding site; other site 695562003714 putative FPP binding hydrophobic cleft; other site 695562003715 dimer interface [polypeptide binding]; other site 695562003716 putative IPP diphosphate binding site; other site 695562003717 ribosome recycling factor; Reviewed; Region: frr; PRK00083 695562003718 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 695562003719 hinge region; other site 695562003720 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 695562003721 putative nucleotide binding site [chemical binding]; other site 695562003722 uridine monophosphate binding site [chemical binding]; other site 695562003723 homohexameric interface [polypeptide binding]; other site 695562003724 elongation factor Ts; Provisional; Region: tsf; PRK09377 695562003725 UBA/TS-N domain; Region: UBA; pfam00627 695562003726 Elongation factor TS; Region: EF_TS; pfam00889 695562003727 Elongation factor TS; Region: EF_TS; pfam00889 695562003728 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 695562003729 rRNA interaction site [nucleotide binding]; other site 695562003730 S8 interaction site; other site 695562003731 putative laminin-1 binding site; other site 695562003732 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 695562003733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 695562003734 S-adenosylmethionine binding site [chemical binding]; other site 695562003735 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 695562003736 GIY-YIG motif/motif A; other site 695562003737 putative active site [active] 695562003738 putative metal binding site [ion binding]; other site 695562003739 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 695562003740 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 695562003741 putative acyl-acceptor binding pocket; other site 695562003742 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 695562003743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 695562003744 S-adenosylmethionine binding site [chemical binding]; other site 695562003745 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 695562003746 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 695562003747 potential frameshift: common BLAST hit: gi|325957560|ref|YP_004292972.1| transposase ORF_C 695562003748 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 695562003749 Glucan-binding protein C; Region: GbpC; pfam08363 695562003750 MucBP domain; Region: MucBP; pfam06458 695562003751 MucBP domain; Region: MucBP; pfam06458 695562003752 MucBP domain; Region: MucBP; pfam06458 695562003753 MucBP domain; Region: MucBP; pfam06458 695562003754 MucBP domain; Region: MucBP; pfam06458 695562003755 MucBP domain; Region: MucBP; pfam06458 695562003756 MucBP domain; Region: MucBP; pfam06458 695562003757 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 695562003758 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 695562003759 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 695562003760 potential frameshift: common BLAST hit: gi|315038560|ref|YP_004032128.1| transposase ORF_C 695562003761 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 695562003762 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 695562003763 active site 695562003764 Zn binding site [ion binding]; other site 695562003765 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 695562003766 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 695562003767 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 695562003768 Walker A/P-loop; other site 695562003769 ATP binding site [chemical binding]; other site 695562003770 Q-loop/lid; other site 695562003771 ABC transporter signature motif; other site 695562003772 Walker B; other site 695562003773 D-loop; other site 695562003774 H-loop/switch region; other site 695562003775 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 695562003776 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 695562003777 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 695562003778 Walker A/P-loop; other site 695562003779 ATP binding site [chemical binding]; other site 695562003780 Q-loop/lid; other site 695562003781 ABC transporter signature motif; other site 695562003782 Walker B; other site 695562003783 D-loop; other site 695562003784 H-loop/switch region; other site 695562003785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 695562003786 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 695562003787 LexA repressor; Validated; Region: PRK00215 695562003788 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 695562003789 putative DNA binding site [nucleotide binding]; other site 695562003790 putative Zn2+ binding site [ion binding]; other site 695562003791 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 695562003792 Catalytic site [active] 695562003793 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 695562003794 active site 695562003795 catalytic triad [active] 695562003796 oxyanion hole [active] 695562003797 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 695562003798 active site 695562003799 Fe-S cluster binding site [ion binding]; other site 695562003800 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 695562003801 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 695562003802 Transposase IS200 like; Region: Y1_Tnp; pfam01797 695562003803 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 695562003804 Probable transposase; Region: OrfB_IS605; pfam01385 695562003805 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 695562003806 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 695562003807 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 695562003808 RimM N-terminal domain; Region: RimM; pfam01782 695562003809 PRC-barrel domain; Region: PRC; pfam05239 695562003810 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 695562003811 signal recognition particle protein; Provisional; Region: PRK10867 695562003812 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 695562003813 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 695562003814 P loop; other site 695562003815 GTP binding site [chemical binding]; other site 695562003816 Signal peptide binding domain; Region: SRP_SPB; pfam02978 695562003817 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 695562003818 putative DNA-binding protein; Validated; Region: PRK00118 695562003819 Sugar transport protein; Region: Sugar_transport; pfam06800 695562003820 amino acid transporter; Region: 2A0306; TIGR00909 695562003821 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 695562003822 Peptidase family C69; Region: Peptidase_C69; pfam03577 695562003823 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 695562003824 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 695562003825 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 695562003826 P loop; other site 695562003827 GTP binding site [chemical binding]; other site 695562003828 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 695562003829 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 695562003830 Walker A/P-loop; other site 695562003831 ATP binding site [chemical binding]; other site 695562003832 Q-loop/lid; other site 695562003833 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 695562003834 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 695562003835 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 695562003836 ABC transporter signature motif; other site 695562003837 Walker B; other site 695562003838 D-loop; other site 695562003839 H-loop/switch region; other site 695562003840 ribonuclease III; Reviewed; Region: rnc; PRK00102 695562003841 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 695562003842 dimerization interface [polypeptide binding]; other site 695562003843 active site 695562003844 metal binding site [ion binding]; metal-binding site 695562003845 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 695562003846 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 695562003847 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 695562003848 peptide binding site [polypeptide binding]; other site 695562003849 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 695562003850 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 695562003851 peptide binding site [polypeptide binding]; other site 695562003852 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 695562003853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 695562003854 dimer interface [polypeptide binding]; other site 695562003855 conserved gate region; other site 695562003856 putative PBP binding loops; other site 695562003857 ABC-ATPase subunit interface; other site 695562003858 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 695562003859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 695562003860 dimer interface [polypeptide binding]; other site 695562003861 conserved gate region; other site 695562003862 putative PBP binding loops; other site 695562003863 ABC-ATPase subunit interface; other site 695562003864 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 695562003865 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 695562003866 Walker A/P-loop; other site 695562003867 ATP binding site [chemical binding]; other site 695562003868 Q-loop/lid; other site 695562003869 ABC transporter signature motif; other site 695562003870 Walker B; other site 695562003871 D-loop; other site 695562003872 H-loop/switch region; other site 695562003873 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 695562003874 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 695562003875 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 695562003876 Walker A/P-loop; other site 695562003877 ATP binding site [chemical binding]; other site 695562003878 Q-loop/lid; other site 695562003879 ABC transporter signature motif; other site 695562003880 Walker B; other site 695562003881 D-loop; other site 695562003882 H-loop/switch region; other site 695562003883 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 695562003884 acyl carrier protein; Provisional; Region: acpP; PRK00982 695562003885 putative phosphate acyltransferase; Provisional; Region: PRK05331 695562003886 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 695562003887 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 695562003888 ssDNA binding site; other site 695562003889 generic binding surface II; other site 695562003890 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 695562003891 ATP binding site [chemical binding]; other site 695562003892 putative Mg++ binding site [ion binding]; other site 695562003893 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 695562003894 nucleotide binding region [chemical binding]; other site 695562003895 ATP-binding site [chemical binding]; other site 695562003896 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 695562003897 DAK2 domain; Region: Dak2; pfam02734 695562003898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 695562003899 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 695562003900 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 695562003901 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 695562003902 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 695562003903 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 695562003904 SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins...; Region: SOCS; cl02533 695562003905 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 695562003906 Thiamine pyrophosphokinase; Region: TPK; cd07995 695562003907 active site 695562003908 dimerization interface [polypeptide binding]; other site 695562003909 thiamine binding site [chemical binding]; other site 695562003910 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 695562003911 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 695562003912 substrate binding site [chemical binding]; other site 695562003913 hexamer interface [polypeptide binding]; other site 695562003914 metal binding site [ion binding]; metal-binding site 695562003915 GTPase RsgA; Reviewed; Region: PRK00098 695562003916 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 695562003917 RNA binding site [nucleotide binding]; other site 695562003918 homodimer interface [polypeptide binding]; other site 695562003919 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 695562003920 GTPase/Zn-binding domain interface [polypeptide binding]; other site 695562003921 GTP/Mg2+ binding site [chemical binding]; other site 695562003922 G4 box; other site 695562003923 G5 box; other site 695562003924 G1 box; other site 695562003925 Switch I region; other site 695562003926 G2 box; other site 695562003927 G3 box; other site 695562003928 Switch II region; other site 695562003929 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 695562003930 Catalytic domain of Protein Kinases; Region: PKc; cd00180 695562003931 active site 695562003932 ATP binding site [chemical binding]; other site 695562003933 substrate binding site [chemical binding]; other site 695562003934 activation loop (A-loop); other site 695562003935 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 695562003936 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 695562003937 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 695562003938 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 695562003939 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 695562003940 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 695562003941 active site 695562003942 16S rRNA methyltransferase B; Provisional; Region: PRK14902 695562003943 NusB family; Region: NusB; pfam01029 695562003944 putative RNA binding site [nucleotide binding]; other site 695562003945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 695562003946 S-adenosylmethionine binding site [chemical binding]; other site 695562003947 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 695562003948 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 695562003949 putative active site [active] 695562003950 substrate binding site [chemical binding]; other site 695562003951 putative cosubstrate binding site; other site 695562003952 catalytic site [active] 695562003953 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 695562003954 substrate binding site [chemical binding]; other site 695562003955 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 695562003956 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 695562003957 ATP binding site [chemical binding]; other site 695562003958 putative Mg++ binding site [ion binding]; other site 695562003959 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 695562003960 nucleotide binding region [chemical binding]; other site 695562003961 ATP-binding site [chemical binding]; other site 695562003962 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 695562003963 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 695562003964 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 695562003965 catalytic site [active] 695562003966 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 695562003967 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 695562003968 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 695562003969 Walker A/P-loop; other site 695562003970 ATP binding site [chemical binding]; other site 695562003971 Q-loop/lid; other site 695562003972 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 695562003973 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 695562003974 ABC transporter signature motif; other site 695562003975 Walker B; other site 695562003976 D-loop; other site 695562003977 H-loop/switch region; other site 695562003978 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 695562003979 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 695562003980 RNA binding surface [nucleotide binding]; other site 695562003981 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 695562003982 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 695562003983 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 695562003984 substrate binding pocket [chemical binding]; other site 695562003985 chain length determination region; other site 695562003986 substrate-Mg2+ binding site; other site 695562003987 catalytic residues [active] 695562003988 aspartate-rich region 1; other site 695562003989 active site lid residues [active] 695562003990 aspartate-rich region 2; other site 695562003991 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 695562003992 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 695562003993 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 695562003994 generic binding surface II; other site 695562003995 generic binding surface I; other site 695562003996 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 695562003997 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 695562003998 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 695562003999 homodimer interface [polypeptide binding]; other site 695562004000 NADP binding site [chemical binding]; other site 695562004001 substrate binding site [chemical binding]; other site 695562004002 transcription antitermination factor NusB; Region: nusB; TIGR01951 695562004003 putative RNA binding site [nucleotide binding]; other site 695562004004 Asp23 family; Region: Asp23; pfam03780 695562004005 elongation factor P; Validated; Region: PRK00529 695562004006 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 695562004007 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 695562004008 RNA binding site [nucleotide binding]; other site 695562004009 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 695562004010 RNA binding site [nucleotide binding]; other site 695562004011 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 695562004012 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 695562004013 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 695562004014 active site 695562004015 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 695562004016 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 695562004017 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 695562004018 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 695562004019 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 695562004020 homodimer interface [polypeptide binding]; other site 695562004021 substrate-cofactor binding pocket; other site 695562004022 catalytic residue [active] 695562004023 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 695562004024 active site 1 [active] 695562004025 dimer interface [polypeptide binding]; other site 695562004026 hexamer interface [polypeptide binding]; other site 695562004027 active site 2 [active] 695562004028 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 695562004029 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 695562004030 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 695562004031 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 695562004032 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 695562004033 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 695562004034 active site 695562004035 Bacterial surface layer protein; Region: SLAP; pfam03217 695562004036 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 695562004037 ArsC family; Region: ArsC; pfam03960 695562004038 putative ArsC-like catalytic residues; other site 695562004039 putative TRX-like catalytic residues [active] 695562004040 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 695562004041 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 695562004042 substrate binding pocket [chemical binding]; other site 695562004043 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 695562004044 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 695562004045 Walker A/P-loop; other site 695562004046 ATP binding site [chemical binding]; other site 695562004047 ABC transporter; Region: ABC_tran; pfam00005 695562004048 Q-loop/lid; other site 695562004049 ABC transporter signature motif; other site 695562004050 Walker B; other site 695562004051 D-loop; other site 695562004052 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 695562004053 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 695562004054 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 695562004055 Walker A/P-loop; other site 695562004056 ATP binding site [chemical binding]; other site 695562004057 Q-loop/lid; other site 695562004058 ABC transporter signature motif; other site 695562004059 Walker B; other site 695562004060 D-loop; other site 695562004061 H-loop/switch region; other site 695562004062 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 695562004063 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 695562004064 active site 695562004065 motif I; other site 695562004066 motif II; other site 695562004067 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 695562004068 Short C-terminal domain; Region: SHOCT; pfam09851 695562004069 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 695562004070 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 695562004071 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 695562004072 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 695562004073 methionine sulfoxide reductase B; Provisional; Region: PRK00222 695562004074 methionine sulfoxide reductase B; Provisional; Region: PRK05508 695562004075 Sugar transport protein; Region: Sugar_transport; pfam06800 695562004076 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 695562004077 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 695562004078 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 695562004079 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 695562004080 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 695562004081 ATP-grasp domain; Region: ATP-grasp_4; cl17255 695562004082 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 695562004083 IMP binding site; other site 695562004084 dimer interface [polypeptide binding]; other site 695562004085 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 695562004086 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 695562004087 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 695562004088 catalytic site [active] 695562004089 subunit interface [polypeptide binding]; other site 695562004090 dihydroorotase; Validated; Region: pyrC; PRK09357 695562004091 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 695562004092 active site 695562004093 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 695562004094 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 695562004095 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 695562004096 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 695562004097 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 695562004098 active site 695562004099 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 695562004100 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 695562004101 heterodimer interface [polypeptide binding]; other site 695562004102 active site 695562004103 FMN binding site [chemical binding]; other site 695562004104 homodimer interface [polypeptide binding]; other site 695562004105 substrate binding site [chemical binding]; other site 695562004106 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 695562004107 active site 695562004108 dimer interface [polypeptide binding]; other site 695562004109 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 695562004110 active site 695562004111 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 695562004112 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 695562004113 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 695562004114 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 695562004115 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 695562004116 motif II; other site 695562004117 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 695562004118 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 695562004119 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 695562004120 Cl- selectivity filter; other site 695562004121 Cl- binding residues [ion binding]; other site 695562004122 pore gating glutamate residue; other site 695562004123 dimer interface [polypeptide binding]; other site 695562004124 H+/Cl- coupling transport residue; other site 695562004125 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 695562004126 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 695562004127 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 695562004128 Coenzyme A binding pocket [chemical binding]; other site 695562004129 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 695562004130 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 695562004131 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 695562004132 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 695562004133 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 695562004134 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 695562004135 Uncharacterized conserved protein [Function unknown]; Region: COG1479 695562004136 Protein of unknown function DUF262; Region: DUF262; pfam03235 695562004137 Protein of unknown function DUF262; Region: DUF262; pfam03235 695562004138 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 695562004139 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 695562004140 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 695562004141 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 695562004142 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 695562004143 ATP binding site [chemical binding]; other site 695562004144 putative Mg++ binding site [ion binding]; other site 695562004145 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 695562004146 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 695562004147 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 695562004148 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 695562004149 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 695562004150 active site 695562004151 DNA binding site [nucleotide binding] 695562004152 Int/Topo IB signature motif; other site 695562004153 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 695562004154 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 695562004155 HsdM N-terminal domain; Region: HsdM_N; pfam12161 695562004156 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 695562004157 Methyltransferase domain; Region: Methyltransf_26; pfam13659 695562004158 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 695562004159 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 695562004160 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 695562004161 metal binding site [ion binding]; metal-binding site 695562004162 active site 695562004163 I-site; other site 695562004164 EAL domain; Region: EAL; pfam00563 695562004165 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 695562004166 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 695562004167 DXD motif; other site 695562004168 Helix-turn-helix domain; Region: HTH_38; pfam13936 695562004169 Bacteriophage T4-like capsid assembly protein (Gp20); Region: Phage_T4_Gp20; pfam07230 695562004170 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 695562004171 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 695562004172 substrate binding pocket [chemical binding]; other site 695562004173 membrane-bound complex binding site; other site 695562004174 hinge residues; other site 695562004175 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 695562004176 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 695562004177 Walker A/P-loop; other site 695562004178 ATP binding site [chemical binding]; other site 695562004179 Q-loop/lid; other site 695562004180 ABC transporter signature motif; other site 695562004181 Walker B; other site 695562004182 D-loop; other site 695562004183 H-loop/switch region; other site 695562004184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 695562004185 dimer interface [polypeptide binding]; other site 695562004186 conserved gate region; other site 695562004187 putative PBP binding loops; other site 695562004188 ABC-ATPase subunit interface; other site 695562004189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 695562004190 dimer interface [polypeptide binding]; other site 695562004191 conserved gate region; other site 695562004192 putative PBP binding loops; other site 695562004193 ABC-ATPase subunit interface; other site 695562004194 Integrase core domain; Region: rve_2; pfam13333 695562004195 potential frameshift: common BLAST hit: gi|336053597|ref|YP_004561884.1| surface layer protein 695562004196 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 695562004197 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 695562004198 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 695562004199 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 695562004200 ligand binding site [chemical binding]; other site 695562004201 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 695562004202 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 695562004203 Walker A/P-loop; other site 695562004204 ATP binding site [chemical binding]; other site 695562004205 Q-loop/lid; other site 695562004206 ABC transporter signature motif; other site 695562004207 Walker B; other site 695562004208 D-loop; other site 695562004209 H-loop/switch region; other site 695562004210 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 695562004211 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 695562004212 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 695562004213 TM-ABC transporter signature motif; other site 695562004214 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 695562004215 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 695562004216 TM-ABC transporter signature motif; other site 695562004217 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 695562004218 potential frameshift: common BLAST hit: gi|325957216|ref|YP_004292628.1| inner membrane transporter YjeM 695562004219 potential frameshift: common BLAST hit: gi|58337693|ref|YP_194278.1| pyrazinamidase-nicotinamidase 695562004220 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 695562004221 Probable transposase; Region: OrfB_IS605; pfam01385 695562004222 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 695562004223 Transposase IS200 like; Region: Y1_Tnp; pfam01797 695562004224 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 695562004225 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 695562004226 catalytic tetrad [active] 695562004227 OsmC-like protein; Region: OsmC; pfam02566 695562004228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 695562004229 putative substrate translocation pore; other site 695562004230 Major Facilitator Superfamily; Region: MFS_1; pfam07690 695562004231 potential frameshift: common BLAST hit: gi|58337702|ref|YP_194287.1| two-component response regulator 695562004232 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 695562004233 synthetase active site [active] 695562004234 NTP binding site [chemical binding]; other site 695562004235 metal binding site [ion binding]; metal-binding site 695562004236 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 695562004237 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 695562004238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 695562004239 Major Facilitator Superfamily; Region: MFS_1; pfam07690 695562004240 putative substrate translocation pore; other site 695562004241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 695562004242 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 695562004243 Beta-lactamase; Region: Beta-lactamase; pfam00144 695562004244 Major Facilitator Superfamily; Region: MFS_1; pfam07690 695562004245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 695562004246 putative substrate translocation pore; other site 695562004247 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 695562004248 Transposase; Region: DDE_Tnp_ISL3; pfam01610 695562004249 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 695562004250 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 695562004251 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 695562004252 active site 695562004253 homodimer interface [polypeptide binding]; other site 695562004254 catalytic site [active] 695562004255 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 695562004256 Melibiase; Region: Melibiase; pfam02065 695562004257 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 695562004258 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 695562004259 Walker A/P-loop; other site 695562004260 ATP binding site [chemical binding]; other site 695562004261 Q-loop/lid; other site 695562004262 ABC transporter signature motif; other site 695562004263 Walker B; other site 695562004264 D-loop; other site 695562004265 H-loop/switch region; other site 695562004266 TOBE domain; Region: TOBE; pfam03459 695562004267 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 695562004268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 695562004269 dimer interface [polypeptide binding]; other site 695562004270 conserved gate region; other site 695562004271 putative PBP binding loops; other site 695562004272 ABC-ATPase subunit interface; other site 695562004273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 695562004274 dimer interface [polypeptide binding]; other site 695562004275 conserved gate region; other site 695562004276 putative PBP binding loops; other site 695562004277 ABC-ATPase subunit interface; other site 695562004278 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 695562004279 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 695562004280 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 695562004281 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 695562004282 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 695562004283 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 695562004284 active site 695562004285 catalytic residues [active] 695562004286 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 695562004287 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 695562004288 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 695562004289 galactokinase; Provisional; Region: PRK05322 695562004290 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 695562004291 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 695562004292 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 695562004293 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 695562004294 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 695562004295 DNA-binding site [nucleotide binding]; DNA binding site 695562004296 UTRA domain; Region: UTRA; pfam07702 695562004297 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 695562004298 dimer interface [polypeptide binding]; other site 695562004299 FMN binding site [chemical binding]; other site 695562004300 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 695562004301 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 695562004302 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 695562004303 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 695562004304 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 695562004305 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 695562004306 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 695562004307 HPr interaction site; other site 695562004308 glycerol kinase (GK) interaction site [polypeptide binding]; other site 695562004309 active site 695562004310 phosphorylation site [posttranslational modification] 695562004311 Transcriptional regulators [Transcription]; Region: PurR; COG1609 695562004312 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 695562004313 DNA binding site [nucleotide binding] 695562004314 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 695562004315 putative dimerization interface [polypeptide binding]; other site 695562004316 putative ligand binding site [chemical binding]; other site 695562004317 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 695562004318 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 695562004319 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 695562004320 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 695562004321 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 695562004322 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 695562004323 NAD binding site [chemical binding]; other site 695562004324 homodimer interface [polypeptide binding]; other site 695562004325 active site 695562004326 substrate binding site [chemical binding]; other site 695562004327 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 695562004328 DNA binding site [nucleotide binding] 695562004329 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 695562004330 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 695562004331 Probable transposase; Region: OrfB_IS605; pfam01385 695562004332 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 695562004333 Transposase IS200 like; Region: Y1_Tnp; pfam01797 695562004334 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 695562004335 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 695562004336 Transcriptional regulators [Transcription]; Region: PurR; COG1609 695562004337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 695562004338 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 695562004339 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 695562004340 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 695562004341 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 695562004342 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 695562004343 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 695562004344 catalytic residues [active] 695562004345 catalytic nucleophile [active] 695562004346 Presynaptic Site I dimer interface [polypeptide binding]; other site 695562004347 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 695562004348 Synaptic Flat tetramer interface [polypeptide binding]; other site 695562004349 Synaptic Site I dimer interface [polypeptide binding]; other site 695562004350 DNA binding site [nucleotide binding] 695562004351 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 695562004352 DNA-binding interface [nucleotide binding]; DNA binding site 695562004353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 695562004354 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 695562004355 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 695562004356 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 695562004357 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 695562004358 Aluminium resistance protein; Region: Alum_res; pfam06838 695562004359 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 695562004360 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 695562004361 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 695562004362 active site residue [active] 695562004363 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 695562004364 Rhomboid family; Region: Rhomboid; pfam01694 695562004365 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 695562004366 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 695562004367 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 695562004368 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 695562004369 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 695562004370 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 695562004371 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 695562004372 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 695562004373 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 695562004374 nucleotide binding site [chemical binding]; other site 695562004375 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786 695562004376 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 695562004377 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 695562004378 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 695562004379 peptidase T; Region: peptidase-T; TIGR01882 695562004380 metal binding site [ion binding]; metal-binding site 695562004381 dimer interface [polypeptide binding]; other site 695562004382 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 695562004383 tetramer (dimer of dimers) interface [polypeptide binding]; other site 695562004384 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 695562004385 NAD binding site [chemical binding]; other site 695562004386 dimer interface [polypeptide binding]; other site 695562004387 substrate binding site [chemical binding]; other site 695562004388 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 695562004389 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 695562004390 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 695562004391 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 695562004392 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 695562004393 putative tRNA-binding site [nucleotide binding]; other site 695562004394 B3/4 domain; Region: B3_4; pfam03483 695562004395 tRNA synthetase B5 domain; Region: B5; smart00874 695562004396 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 695562004397 dimer interface [polypeptide binding]; other site 695562004398 motif 1; other site 695562004399 motif 3; other site 695562004400 motif 2; other site 695562004401 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 695562004402 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 695562004403 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 695562004404 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 695562004405 dimer interface [polypeptide binding]; other site 695562004406 motif 1; other site 695562004407 active site 695562004408 motif 2; other site 695562004409 motif 3; other site 695562004410 Predicted transcriptional regulators [Transcription]; Region: COG1733 695562004411 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 695562004412 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 695562004413 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 695562004414 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 695562004415 Acylphosphatase; Region: Acylphosphatase; pfam00708 695562004416 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 695562004417 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 695562004418 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 695562004419 dimerization interface [polypeptide binding]; other site 695562004420 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 695562004421 dimer interface [polypeptide binding]; other site 695562004422 phosphorylation site [posttranslational modification] 695562004423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 695562004424 ATP binding site [chemical binding]; other site 695562004425 Mg2+ binding site [ion binding]; other site 695562004426 G-X-G motif; other site 695562004427 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 695562004428 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 695562004429 active site 695562004430 phosphorylation site [posttranslational modification] 695562004431 intermolecular recognition site; other site 695562004432 dimerization interface [polypeptide binding]; other site 695562004433 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 695562004434 DNA binding site [nucleotide binding] 695562004435 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 695562004436 hypothetical protein; Provisional; Region: PRK13670 695562004437 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 695562004438 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 695562004439 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 695562004440 Zn2+ binding site [ion binding]; other site 695562004441 Mg2+ binding site [ion binding]; other site 695562004442 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 695562004443 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 695562004444 active site 695562004445 (T/H)XGH motif; other site 695562004446 GTPase YqeH; Provisional; Region: PRK13796 695562004447 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 695562004448 GTP/Mg2+ binding site [chemical binding]; other site 695562004449 G4 box; other site 695562004450 G5 box; other site 695562004451 G1 box; other site 695562004452 Switch I region; other site 695562004453 G2 box; other site 695562004454 G3 box; other site 695562004455 Switch II region; other site 695562004456 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase 695562004457 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 695562004458 active site 695562004459 motif I; other site 695562004460 motif II; other site 695562004461 adenosine deaminase; Provisional; Region: PRK09358 695562004462 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 695562004463 active site 695562004464 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 695562004465 23S rRNA binding site [nucleotide binding]; other site 695562004466 L21 binding site [polypeptide binding]; other site 695562004467 L13 binding site [polypeptide binding]; other site 695562004468 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 695562004469 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 695562004470 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 695562004471 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 695562004472 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 695562004473 Domain of unknown function (DUF389); Region: DUF389; pfam04087 695562004474 Family description; Region: ACT_7; pfam13840 695562004475 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 695562004476 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 695562004477 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 695562004478 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 695562004479 active site 695562004480 dimer interface [polypeptide binding]; other site 695562004481 motif 1; other site 695562004482 motif 2; other site 695562004483 motif 3; other site 695562004484 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 695562004485 anticodon binding site; other site 695562004486 primosomal protein DnaI; Reviewed; Region: PRK08939 695562004487 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 695562004488 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 695562004489 Walker A motif; other site 695562004490 ATP binding site [chemical binding]; other site 695562004491 Walker B motif; other site 695562004492 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 695562004493 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 695562004494 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 695562004495 ATP cone domain; Region: ATP-cone; pfam03477 695562004496 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 695562004497 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 695562004498 CoA-binding site [chemical binding]; other site 695562004499 ATP-binding [chemical binding]; other site 695562004500 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 695562004501 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 695562004502 DNA binding site [nucleotide binding] 695562004503 catalytic residue [active] 695562004504 H2TH interface [polypeptide binding]; other site 695562004505 putative catalytic residues [active] 695562004506 turnover-facilitating residue; other site 695562004507 intercalation triad [nucleotide binding]; other site 695562004508 8OG recognition residue [nucleotide binding]; other site 695562004509 putative reading head residues; other site 695562004510 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 695562004511 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 695562004512 DNA polymerase I; Provisional; Region: PRK05755 695562004513 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 695562004514 active site 695562004515 metal binding site 1 [ion binding]; metal-binding site 695562004516 putative 5' ssDNA interaction site; other site 695562004517 metal binding site 3; metal-binding site 695562004518 metal binding site 2 [ion binding]; metal-binding site 695562004519 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 695562004520 putative DNA binding site [nucleotide binding]; other site 695562004521 putative metal binding site [ion binding]; other site 695562004522 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 695562004523 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 695562004524 active site 695562004525 DNA binding site [nucleotide binding] 695562004526 catalytic site [active] 695562004527 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 695562004528 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 695562004529 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 695562004530 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 695562004531 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 695562004532 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 695562004533 purine monophosphate binding site [chemical binding]; other site 695562004534 dimer interface [polypeptide binding]; other site 695562004535 putative catalytic residues [active] 695562004536 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 695562004537 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 695562004538 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 695562004539 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 695562004540 active site 695562004541 substrate binding site [chemical binding]; other site 695562004542 cosubstrate binding site; other site 695562004543 catalytic site [active] 695562004544 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 695562004545 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 695562004546 dimerization interface [polypeptide binding]; other site 695562004547 putative ATP binding site [chemical binding]; other site 695562004548 amidophosphoribosyltransferase; Provisional; Region: PRK07272 695562004549 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 695562004550 active site 695562004551 tetramer interface [polypeptide binding]; other site 695562004552 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 695562004553 active site 695562004554 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 695562004555 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 695562004556 dimerization interface [polypeptide binding]; other site 695562004557 ATP binding site [chemical binding]; other site 695562004558 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 695562004559 dimerization interface [polypeptide binding]; other site 695562004560 ATP binding site [chemical binding]; other site 695562004561 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 695562004562 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 695562004563 putative active site [active] 695562004564 catalytic triad [active] 695562004565 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 695562004566 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 695562004567 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 695562004568 ATP binding site [chemical binding]; other site 695562004569 active site 695562004570 substrate binding site [chemical binding]; other site 695562004571 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 695562004572 ATP-grasp domain; Region: ATP-grasp; pfam02222 695562004573 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 695562004574 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 695562004575 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 695562004576 Potassium binding sites [ion binding]; other site 695562004577 Cesium cation binding sites [ion binding]; other site 695562004578 HflC protein; Region: hflC; TIGR01932 695562004579 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 695562004580 RelB antitoxin; Region: RelB; cl01171 695562004581 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 695562004582 Zn binding site [ion binding]; other site 695562004583 amino-acid N-acetyltransferase; Region: PLN02825 695562004584 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 695562004585 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 695562004586 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 695562004587 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 695562004588 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 695562004589 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 695562004590 Bacterial surface layer protein; Region: SLAP; pfam03217 695562004591 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 695562004592 putative tRNA-binding site [nucleotide binding]; other site 695562004593 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 695562004594 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 695562004595 catalytic residues [active] 695562004596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 695562004597 S-adenosylmethionine binding site [chemical binding]; other site 695562004598 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 695562004599 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 695562004600 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 695562004601 Walker A/P-loop; other site 695562004602 ATP binding site [chemical binding]; other site 695562004603 Q-loop/lid; other site 695562004604 ABC transporter signature motif; other site 695562004605 Walker B; other site 695562004606 D-loop; other site 695562004607 H-loop/switch region; other site 695562004608 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 695562004609 HIT family signature motif; other site 695562004610 catalytic residue [active] 695562004611 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 695562004612 SurA N-terminal domain; Region: SurA_N_3; cl07813 695562004613 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 695562004614 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 695562004615 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 695562004616 generic binding surface I; other site 695562004617 generic binding surface II; other site 695562004618 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 695562004619 Zn2+ binding site [ion binding]; other site 695562004620 Mg2+ binding site [ion binding]; other site 695562004621 P-loop containing region of AAA domain; Region: AAA_29; cl17516 695562004622 AAA domain; Region: AAA_23; pfam13476 695562004623 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 695562004624 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 695562004625 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 695562004626 active site 695562004627 metal binding site [ion binding]; metal-binding site 695562004628 DNA binding site [nucleotide binding] 695562004629 hypothetical protein; Provisional; Region: PRK13676 695562004630 Transglycosylase; Region: Transgly; pfam00912 695562004631 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 695562004632 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 695562004633 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 695562004634 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 695562004635 active site 695562004636 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 695562004637 active site 695562004638 substrate binding site [chemical binding]; other site 695562004639 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 695562004640 FMN binding site [chemical binding]; other site 695562004641 putative catalytic residues [active] 695562004642 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 695562004643 amphipathic channel; other site 695562004644 Asn-Pro-Ala signature motifs; other site 695562004645 Integrase core domain; Region: rve; pfam00665 695562004646 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 695562004647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 695562004648 Major Facilitator Superfamily; Region: MFS_1; pfam07690 695562004649 putative substrate translocation pore; other site 695562004650 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 695562004651 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 695562004652 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 695562004653 ligand binding site [chemical binding]; other site 695562004654 flexible hinge region; other site 695562004655 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 695562004656 putative switch regulator; other site 695562004657 non-specific DNA interactions [nucleotide binding]; other site 695562004658 DNA binding site [nucleotide binding] 695562004659 sequence specific DNA binding site [nucleotide binding]; other site 695562004660 putative cAMP binding site [chemical binding]; other site 695562004661 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 695562004662 intersubunit interface [polypeptide binding]; other site 695562004663 active site 695562004664 zinc binding site [ion binding]; other site 695562004665 Na+ binding site [ion binding]; other site 695562004666 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 695562004667 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 695562004668 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 695562004669 active site 695562004670 HIGH motif; other site 695562004671 KMSK motif region; other site 695562004672 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 695562004673 tRNA binding surface [nucleotide binding]; other site 695562004674 anticodon binding site; other site 695562004675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 695562004676 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 695562004677 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 695562004678 putative substrate binding site [chemical binding]; other site 695562004679 putative ATP binding site [chemical binding]; other site 695562004680 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 695562004681 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 695562004682 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 695562004683 PspC domain; Region: PspC; pfam04024 695562004684 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 695562004685 nudix motif; other site 695562004686 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 695562004687 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 695562004688 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 695562004689 active site 695562004690 Isochorismatase family; Region: Isochorismatase; pfam00857 695562004691 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 695562004692 catalytic triad [active] 695562004693 conserved cis-peptide bond; other site 695562004694 potential frameshift: common BLAST hit: gi|295693767|ref|YP_003602377.1| transposase 695562004695 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 695562004696 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 695562004697 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 695562004698 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 695562004699 HIGH motif; other site 695562004700 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 695562004701 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 695562004702 active site 695562004703 KMSKS motif; other site 695562004704 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 695562004705 tRNA binding surface [nucleotide binding]; other site 695562004706 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 695562004707 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 695562004708 active site 695562004709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 695562004710 Major Facilitator Superfamily; Region: MFS_1; pfam07690 695562004711 putative substrate translocation pore; other site 695562004712 S-adenosylmethionine synthetase; Validated; Region: PRK05250 695562004713 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 695562004714 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 695562004715 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 695562004716 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 695562004717 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 695562004718 intersubunit interface [polypeptide binding]; other site 695562004719 seryl-tRNA synthetase; Provisional; Region: PRK05431 695562004720 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 695562004721 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 695562004722 dimer interface [polypeptide binding]; other site 695562004723 active site 695562004724 motif 1; other site 695562004725 motif 2; other site 695562004726 motif 3; other site 695562004727 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 695562004728 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 695562004729 Uncharacterized conserved protein [Function unknown]; Region: COG0398 695562004730 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 695562004731 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 695562004732 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 695562004733 non-specific DNA binding site [nucleotide binding]; other site 695562004734 salt bridge; other site 695562004735 sequence-specific DNA binding site [nucleotide binding]; other site 695562004736 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 695562004737 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 695562004738 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 695562004739 NAD(P) binding site [chemical binding]; other site 695562004740 catalytic residues [active] 695562004741 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 695562004742 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 695562004743 tetramer interface [polypeptide binding]; other site 695562004744 active site 695562004745 Transcriptional regulator [Transcription]; Region: LysR; COG0583 695562004746 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 695562004747 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 695562004748 Transcriptional regulator [Transcription]; Region: LysR; COG0583 695562004749 dimerization interface [polypeptide binding]; other site 695562004750 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 695562004751 Double zinc ribbon; Region: DZR; pfam12773 695562004752 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 695562004753 MMPL family; Region: MMPL; pfam03176 695562004754 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 695562004755 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 695562004756 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 695562004757 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 695562004758 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 695562004759 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 695562004760 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 695562004761 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 695562004762 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 695562004763 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 695562004764 Cl binding site [ion binding]; other site 695562004765 oligomer interface [polypeptide binding]; other site 695562004766 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 695562004767 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 695562004768 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 695562004769 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 695562004770 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 695562004771 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 695562004772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 695562004773 dimer interface [polypeptide binding]; other site 695562004774 conserved gate region; other site 695562004775 ABC-ATPase subunit interface; other site 695562004776 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 695562004777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 695562004778 dimer interface [polypeptide binding]; other site 695562004779 conserved gate region; other site 695562004780 putative PBP binding loops; other site 695562004781 ABC-ATPase subunit interface; other site 695562004782 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 695562004783 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 695562004784 Walker A/P-loop; other site 695562004785 ATP binding site [chemical binding]; other site 695562004786 Q-loop/lid; other site 695562004787 ABC transporter signature motif; other site 695562004788 Walker B; other site 695562004789 D-loop; other site 695562004790 H-loop/switch region; other site 695562004791 TOBE domain; Region: TOBE_2; pfam08402 695562004792 Peptidase family C69; Region: Peptidase_C69; pfam03577 695562004793 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 695562004794 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 695562004795 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 695562004796 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 695562004797 active site 695562004798 catalytic site [active] 695562004799 substrate binding site [chemical binding]; other site 695562004800 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 695562004801 Predicted membrane protein [Function unknown]; Region: COG2323 695562004802 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 695562004803 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 695562004804 Vesicle transport v-SNARE protein N-terminus; Region: V-SNARE; pfam05008 695562004805 Glucan-binding protein C; Region: GbpC; pfam08363 695562004806 MucBP domain; Region: MucBP; pfam06458 695562004807 MucBP domain; Region: MucBP; pfam06458 695562004808 MucBP domain; Region: MucBP; pfam06458 695562004809 MucBP domain; Region: MucBP; pfam06458 695562004810 MucBP domain; Region: MucBP; pfam06458 695562004811 MucBP domain; Region: MucBP; pfam06458 695562004812 MucBP domain; Region: MucBP; pfam06458 695562004813 MucBP domain; Region: MucBP; pfam06458 695562004814 MucBP domain; Region: MucBP; pfam06458 695562004815 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 695562004816 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 695562004817 PAS domain; Region: PAS_10; pfam13596 695562004818 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 695562004819 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 695562004820 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 695562004821 Walker A/P-loop; other site 695562004822 ATP binding site [chemical binding]; other site 695562004823 Q-loop/lid; other site 695562004824 ABC transporter signature motif; other site 695562004825 Walker B; other site 695562004826 D-loop; other site 695562004827 H-loop/switch region; other site 695562004828 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 695562004829 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 695562004830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 695562004831 active site 695562004832 phosphorylation site [posttranslational modification] 695562004833 intermolecular recognition site; other site 695562004834 dimerization interface [polypeptide binding]; other site 695562004835 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 695562004836 DNA binding site [nucleotide binding] 695562004837 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 695562004838 HAMP domain; Region: HAMP; pfam00672 695562004839 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 695562004840 dimer interface [polypeptide binding]; other site 695562004841 phosphorylation site [posttranslational modification] 695562004842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 695562004843 ATP binding site [chemical binding]; other site 695562004844 Mg2+ binding site [ion binding]; other site 695562004845 G-X-G motif; other site 695562004846 Predicted membrane protein [Function unknown]; Region: COG3212 695562004847 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 695562004848 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 695562004849 Predicted membrane protein [Function unknown]; Region: COG3212 695562004850 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 695562004851 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 695562004852 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 695562004853 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 695562004854 Coenzyme A binding pocket [chemical binding]; other site 695562004855 Transcriptional regulators [Transcription]; Region: MarR; COG1846 695562004856 MarR family; Region: MarR; pfam01047 695562004857 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 695562004858 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 695562004859 peptide binding site [polypeptide binding]; other site 695562004860 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 695562004861 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 695562004862 elongation factor P; Validated; Region: PRK00529 695562004863 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 695562004864 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 695562004865 RNA binding site [nucleotide binding]; other site 695562004866 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 695562004867 RNA binding site [nucleotide binding]; other site 695562004868 pantothenate kinase; Provisional; Region: PRK05439 695562004869 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 695562004870 ATP-binding site [chemical binding]; other site 695562004871 CoA-binding site [chemical binding]; other site 695562004872 Mg2+-binding site [ion binding]; other site 695562004873 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 695562004874 active site 695562004875 catalytic triad [active] 695562004876 oxyanion hole [active] 695562004877 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 695562004878 Coenzyme A binding pocket [chemical binding]; other site 695562004879 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 695562004880 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 695562004881 substrate binding pocket [chemical binding]; other site 695562004882 membrane-bound complex binding site; other site 695562004883 hinge residues; other site 695562004884 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 695562004885 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 695562004886 Walker A/P-loop; other site 695562004887 ATP binding site [chemical binding]; other site 695562004888 Q-loop/lid; other site 695562004889 ABC transporter signature motif; other site 695562004890 Walker B; other site 695562004891 D-loop; other site 695562004892 H-loop/switch region; other site 695562004893 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 695562004894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 695562004895 dimer interface [polypeptide binding]; other site 695562004896 conserved gate region; other site 695562004897 putative PBP binding loops; other site 695562004898 ABC-ATPase subunit interface; other site 695562004899 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 695562004900 Part of AAA domain; Region: AAA_19; pfam13245 695562004901 Family description; Region: UvrD_C_2; pfam13538 695562004902 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 695562004903 active site 695562004904 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 695562004905 catalytic core [active] 695562004906 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 695562004907 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 695562004908 Probable transposase; Region: OrfB_IS605; pfam01385 695562004909 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 695562004910 Transposase IS200 like; Region: Y1_Tnp; pfam01797 695562004911 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 695562004912 Walker A/P-loop; other site 695562004913 ATP binding site [chemical binding]; other site 695562004914 Predicted membrane protein [Function unknown]; Region: COG4640 695562004915 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 695562004916 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 695562004917 active pocket/dimerization site; other site 695562004918 active site 695562004919 phosphorylation site [posttranslational modification] 695562004920 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 695562004921 active site 695562004922 homodimer interface [polypeptide binding]; other site 695562004923 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 695562004924 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 695562004925 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 695562004926 putative active site [active] 695562004927 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 695562004928 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 695562004929 NAD binding site [chemical binding]; other site 695562004930 sugar binding site [chemical binding]; other site 695562004931 divalent metal binding site [ion binding]; other site 695562004932 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 695562004933 dimer interface [polypeptide binding]; other site 695562004934 Helix-turn-helix domain; Region: HTH_38; pfam13936 695562004935 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 695562004936 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 695562004937 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 695562004938 Coenzyme A binding pocket [chemical binding]; other site 695562004939 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 695562004940 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 695562004941 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 695562004942 active site 695562004943 tetramer interface; other site 695562004944 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 695562004945 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 695562004946 NADP binding site [chemical binding]; other site 695562004947 active site 695562004948 putative substrate binding site [chemical binding]; other site 695562004949 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 695562004950 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 695562004951 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 695562004952 substrate binding site; other site 695562004953 tetramer interface; other site 695562004954 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 695562004955 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 695562004956 NAD binding site [chemical binding]; other site 695562004957 substrate binding site [chemical binding]; other site 695562004958 homodimer interface [polypeptide binding]; other site 695562004959 active site 695562004960 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 695562004961 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 695562004962 DNA binding residues [nucleotide binding] 695562004963 dimer interface [polypeptide binding]; other site 695562004964 Methyltransferase domain; Region: Methyltransf_31; pfam13847 695562004965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 695562004966 S-adenosylmethionine binding site [chemical binding]; other site 695562004967 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 695562004968 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 695562004969 HPr interaction site; other site 695562004970 glycerol kinase (GK) interaction site [polypeptide binding]; other site 695562004971 active site 695562004972 phosphorylation site [posttranslational modification] 695562004973 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 695562004974 BCCT family transporter; Region: BCCT; pfam02028 695562004975 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 695562004976 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 695562004977 active site 695562004978 metal-binding site 695562004979 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 695562004980 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes [Cell envelope biogenesis, outer membrane]; Region: LicC; COG4750 695562004981 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 695562004982 Phosphotransferase enzyme family; Region: APH; pfam01636 695562004983 active site 695562004984 ATP binding site [chemical binding]; other site 695562004985 substrate binding site [chemical binding]; other site 695562004986 dimer interface [polypeptide binding]; other site 695562004987 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 695562004988 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 695562004989 potential frameshift: common BLAST hit: gi|161508229|ref|YP_001576727.1| transposase ORF_C 695562004990 potential frameshift: common BLAST hit: gi|161508229|ref|YP_001576727.1| transposase ORF_C 695562004991 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 695562004992 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 695562004993 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 695562004994 potential frameshift: common BLAST hit: gi|325957560|ref|YP_004292972.1| transposase ORF_C 695562004995 Transposase; Region: DEDD_Tnp_IS110; pfam01548 695562004996 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 695562004997 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 695562004998 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 695562004999 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 695562005000 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 695562005001 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 695562005002 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 695562005003 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 695562005004 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 695562005005 UDP-galactopyranose mutase; Region: GLF; pfam03275 695562005006 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 695562005007 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 695562005008 active site 695562005009 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 695562005010 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 695562005011 Ligand binding site; other site 695562005012 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 695562005013 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 695562005014 Probable Catalytic site; other site 695562005015 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 695562005016 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 695562005017 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 695562005018 active site 695562005019 Bacterial sugar transferase; Region: Bac_transf; pfam02397 695562005020 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 695562005021 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 695562005022 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 695562005023 Nucleotide binding site [chemical binding]; other site 695562005024 DTAP/Switch II; other site 695562005025 Switch I; other site 695562005026 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 695562005027 Chain length determinant protein; Region: Wzz; cl15801 695562005028 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 695562005029 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 695562005030 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 695562005031 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 695562005032 HflX GTPase family; Region: HflX; cd01878 695562005033 G1 box; other site 695562005034 GTP/Mg2+ binding site [chemical binding]; other site 695562005035 Switch I region; other site 695562005036 G2 box; other site 695562005037 G3 box; other site 695562005038 Switch II region; other site 695562005039 G4 box; other site 695562005040 G5 box; other site 695562005041 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 695562005042 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 695562005043 NlpC/P60 family; Region: NLPC_P60; pfam00877 695562005044 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 695562005045 NlpC/P60 family; Region: NLPC_P60; pfam00877 695562005046 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 695562005047 NlpC/P60 family; Region: NLPC_P60; pfam00877 695562005048 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 695562005049 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 695562005050 catalytic site [active] 695562005051 G-X2-G-X-G-K; other site 695562005052 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 695562005053 putative active site [active] 695562005054 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 695562005055 Uncharacterized conserved protein [Function unknown]; Region: COG2966 695562005056 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 695562005057 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 695562005058 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 695562005059 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 695562005060 Walker A/P-loop; other site 695562005061 ATP binding site [chemical binding]; other site 695562005062 Q-loop/lid; other site 695562005063 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 695562005064 ABC transporter signature motif; other site 695562005065 Walker B; other site 695562005066 D-loop; other site 695562005067 ABC transporter; Region: ABC_tran_2; pfam12848 695562005068 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 695562005069 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 695562005070 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 695562005071 Protein of unknown function (DUF554); Region: DUF554; pfam04474 695562005072 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 695562005073 oligoendopeptidase F; Region: pepF; TIGR00181 695562005074 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 695562005075 active site 695562005076 Zn binding site [ion binding]; other site 695562005077 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 695562005078 CAAX protease self-immunity; Region: Abi; pfam02517 695562005079 L-lactate permease; Region: Lactate_perm; cl00701 695562005080 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 695562005081 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 695562005082 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 695562005083 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 695562005084 dimer interface [polypeptide binding]; other site 695562005085 putative PBP binding regions; other site 695562005086 ABC-ATPase subunit interface; other site 695562005087 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 695562005088 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 695562005089 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 695562005090 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 695562005091 intersubunit interface [polypeptide binding]; other site 695562005092 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 695562005093 dimerization interface [polypeptide binding]; other site 695562005094 putative DNA binding site [nucleotide binding]; other site 695562005095 putative Zn2+ binding site [ion binding]; other site 695562005096 LytTr DNA-binding domain; Region: LytTR; smart00850 695562005097 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 695562005098 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 695562005099 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 695562005100 active site 695562005101 phosphorylation site [posttranslational modification] 695562005102 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 695562005103 active site 695562005104 P-loop; other site 695562005105 phosphorylation site [posttranslational modification] 695562005106 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 695562005107 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 695562005108 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 695562005109 putative substrate binding site [chemical binding]; other site 695562005110 putative ATP binding site [chemical binding]; other site 695562005111 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 695562005112 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 695562005113 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 695562005114 potential frameshift: common BLAST hit: gi|213693252|ref|YP_002323838.1| filamentation induced by cAMP protein Fic 695562005115 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 695562005116 salt bridge; other site 695562005117 non-specific DNA binding site [nucleotide binding]; other site 695562005118 sequence-specific DNA binding site [nucleotide binding]; other site 695562005119 putative alpha-glucosidase; Provisional; Region: PRK10658 695562005120 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 695562005121 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 695562005122 trimer interface [polypeptide binding]; other site 695562005123 active site 695562005124 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 695562005125 catalytic site [active] 695562005126 Enterocin A Immunity; Region: EntA_Immun; pfam08951 695562005127 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 695562005128 teramer interface [polypeptide binding]; other site 695562005129 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 695562005130 active site 695562005131 FMN binding site [chemical binding]; other site 695562005132 catalytic residues [active] 695562005133 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 695562005134 aspartate racemase; Region: asp_race; TIGR00035 695562005135 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 695562005136 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 695562005137 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 695562005138 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 695562005139 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 695562005140 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 695562005141 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 695562005142 dimer interface [polypeptide binding]; other site 695562005143 phosphorylation site [posttranslational modification] 695562005144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 695562005145 ATP binding site [chemical binding]; other site 695562005146 Mg2+ binding site [ion binding]; other site 695562005147 G-X-G motif; other site 695562005148 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 695562005149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 695562005150 active site 695562005151 phosphorylation site [posttranslational modification] 695562005152 intermolecular recognition site; other site 695562005153 dimerization interface [polypeptide binding]; other site 695562005154 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 695562005155 DNA binding site [nucleotide binding] 695562005156 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 695562005157 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 695562005158 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 695562005159 Walker A/P-loop; other site 695562005160 ATP binding site [chemical binding]; other site 695562005161 Q-loop/lid; other site 695562005162 ABC transporter signature motif; other site 695562005163 Walker B; other site 695562005164 D-loop; other site 695562005165 H-loop/switch region; other site 695562005166 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 695562005167 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 695562005168 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 695562005169 Walker A/P-loop; other site 695562005170 ATP binding site [chemical binding]; other site 695562005171 Q-loop/lid; other site 695562005172 ABC transporter signature motif; other site 695562005173 Walker B; other site 695562005174 D-loop; other site 695562005175 H-loop/switch region; other site 695562005176 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 695562005177 GTP-binding protein YchF; Reviewed; Region: PRK09601 695562005178 YchF GTPase; Region: YchF; cd01900 695562005179 G1 box; other site 695562005180 GTP/Mg2+ binding site [chemical binding]; other site 695562005181 Switch I region; other site 695562005182 G2 box; other site 695562005183 Switch II region; other site 695562005184 G3 box; other site 695562005185 G4 box; other site 695562005186 G5 box; other site 695562005187 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 695562005188 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 695562005189 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 695562005190 ParB-like nuclease domain; Region: ParB; smart00470 695562005191 Helix-turn-helix; Region: HTH_3; pfam01381 695562005192 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 695562005193 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 695562005194 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 695562005195 ParB-like nuclease domain; Region: ParBc; pfam02195 695562005196 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 695562005197 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 695562005198 S-adenosylmethionine binding site [chemical binding]; other site 695562005199 Colicin V production protein; Region: Colicin_V; pfam02674 695562005200 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 695562005201 ApbE family; Region: ApbE; pfam02424 695562005202 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 695562005203 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 695562005204 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 695562005205 Predicted flavoprotein [General function prediction only]; Region: COG0431 695562005206 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 695562005207 Predicted flavoprotein [General function prediction only]; Region: COG0431 695562005208 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 695562005209 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 695562005210 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 695562005211 WHG domain; Region: WHG; pfam13305 695562005212 Peptidase family C69; Region: Peptidase_C69; pfam03577 695562005213 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 695562005214 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 695562005215 Walker A/P-loop; other site 695562005216 ATP binding site [chemical binding]; other site 695562005217 Q-loop/lid; other site 695562005218 ABC transporter signature motif; other site 695562005219 Walker B; other site 695562005220 D-loop; other site 695562005221 H-loop/switch region; other site 695562005222 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 695562005223 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 695562005224 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 695562005225 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 695562005226 catalytic core [active] 695562005227 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 695562005228 Putative serine esterase (DUF676); Region: DUF676; pfam05057 695562005229 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 695562005230 hypothetical protein; Validated; Region: PRK02101 695562005231 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 695562005232 nucleotide binding site/active site [active] 695562005233 HIT family signature motif; other site 695562005234 catalytic residue [active] 695562005235 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 695562005236 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 695562005237 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 695562005238 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 695562005239 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 695562005240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 695562005241 putative substrate translocation pore; other site 695562005242 POT family; Region: PTR2; cl17359 695562005243 Peptidase family M1; Region: Peptidase_M1; pfam01433 695562005244 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 695562005245 Zn binding site [ion binding]; other site 695562005246 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 695562005247 potential frameshift: common BLAST hit: gi|42519172|ref|NP_965102.1| ABC transporter ATPase and permease components 695562005248 drug efflux system protein MdtG; Provisional; Region: PRK09874 695562005249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 695562005250 putative substrate translocation pore; other site 695562005251 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 695562005252 putative ADP-ribose binding site [chemical binding]; other site 695562005253 putative active site [active] 695562005254 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 695562005255 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 695562005256 Probable transposase; Region: OrfB_IS605; pfam01385 695562005257 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 695562005258 Transposase IS200 like; Region: Y1_Tnp; pfam01797 695562005259 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 695562005260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 695562005261 dimer interface [polypeptide binding]; other site 695562005262 conserved gate region; other site 695562005263 putative PBP binding loops; other site 695562005264 ABC-ATPase subunit interface; other site 695562005265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 695562005266 dimer interface [polypeptide binding]; other site 695562005267 conserved gate region; other site 695562005268 ABC-ATPase subunit interface; other site 695562005269 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 695562005270 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 695562005271 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 695562005272 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 695562005273 Walker A/P-loop; other site 695562005274 ATP binding site [chemical binding]; other site 695562005275 Q-loop/lid; other site 695562005276 ABC transporter signature motif; other site 695562005277 Walker B; other site 695562005278 D-loop; other site 695562005279 H-loop/switch region; other site 695562005280 TOBE domain; Region: TOBE_2; pfam08402 695562005281 beta-phosphoglucomutase; Region: bPGM; TIGR01990 695562005282 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 695562005283 motif II; other site 695562005284 maltose phosphorylase; Provisional; Region: PRK13807 695562005285 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 695562005286 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 695562005287 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 695562005288 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 695562005289 homodimer interface [polypeptide binding]; other site 695562005290 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 695562005291 active site 695562005292 homodimer interface [polypeptide binding]; other site 695562005293 catalytic site [active] 695562005294 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 695562005295 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 695562005296 Ca binding site [ion binding]; other site 695562005297 active site 695562005298 catalytic site [active] 695562005299 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 695562005300 propionate/acetate kinase; Provisional; Region: PRK12379 695562005301 Transcriptional regulators [Transcription]; Region: PurR; COG1609 695562005302 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 695562005303 DNA binding site [nucleotide binding] 695562005304 domain linker motif; other site 695562005305 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 695562005306 ligand binding site [chemical binding]; other site 695562005307 dimerization interface [polypeptide binding]; other site 695562005308 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 695562005309 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 695562005310 potential frameshift: common BLAST hit: gi|325957660|ref|YP_004293072.1| ABC transporter ATP-binding and membrane spanning protein 695562005311 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 695562005312 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 695562005313 non-specific DNA binding site [nucleotide binding]; other site 695562005314 salt bridge; other site 695562005315 sequence-specific DNA binding site [nucleotide binding]; other site 695562005316 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 695562005317 glycerol kinase; Provisional; Region: glpK; PRK00047 695562005318 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 695562005319 N- and C-terminal domain interface [polypeptide binding]; other site 695562005320 active site 695562005321 MgATP binding site [chemical binding]; other site 695562005322 catalytic site [active] 695562005323 metal binding site [ion binding]; metal-binding site 695562005324 glycerol binding site [chemical binding]; other site 695562005325 homotetramer interface [polypeptide binding]; other site 695562005326 homodimer interface [polypeptide binding]; other site 695562005327 FBP binding site [chemical binding]; other site 695562005328 protein IIAGlc interface [polypeptide binding]; other site 695562005329 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 695562005330 dimer interface [polypeptide binding]; other site 695562005331 substrate binding site [chemical binding]; other site 695562005332 ATP binding site [chemical binding]; other site 695562005333 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 695562005334 non-specific DNA binding site [nucleotide binding]; other site 695562005335 salt bridge; other site 695562005336 sequence-specific DNA binding site [nucleotide binding]; other site 695562005337 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 695562005338 AAA domain; Region: AAA_14; pfam13173 695562005339 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 695562005340 catalytic triad [active] 695562005341 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 695562005342 NlpC/P60 family; Region: NLPC_P60; pfam00877 695562005343 EamA-like transporter family; Region: EamA; pfam00892 695562005344 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 695562005345 EamA-like transporter family; Region: EamA; pfam00892 695562005346 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 695562005347 EamA-like transporter family; Region: EamA; pfam00892 695562005348 EamA-like transporter family; Region: EamA; pfam00892 695562005349 adenylosuccinate lyase; Provisional; Region: PRK07492 695562005350 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 695562005351 tetramer interface [polypeptide binding]; other site 695562005352 active site 695562005353 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 695562005354 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 695562005355 GDP-binding site [chemical binding]; other site 695562005356 ACT binding site; other site 695562005357 IMP binding site; other site 695562005358 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 695562005359 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 695562005360 active site 695562005361 Uncharacterized conserved protein [Function unknown]; Region: COG3589 695562005362 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 695562005363 asparagine synthetase A; Reviewed; Region: PRK06462 695562005364 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 695562005365 dimer interface [polypeptide binding]; other site 695562005366 active site 695562005367 Amino acid permease; Region: AA_permease_2; pfam13520 695562005368 Peptidase C26; Region: Peptidase_C26; pfam07722 695562005369 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 695562005370 catalytic triad [active] 695562005371 putative transport protein YifK; Provisional; Region: PRK10746 695562005372 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 695562005373 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 695562005374 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 695562005375 Catalytic site [active] 695562005376 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 695562005377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 695562005378 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 695562005379 Walker A motif; other site 695562005380 ATP binding site [chemical binding]; other site 695562005381 Walker B motif; other site 695562005382 arginine finger; other site 695562005383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 695562005384 Walker A motif; other site 695562005385 ATP binding site [chemical binding]; other site 695562005386 Walker B motif; other site 695562005387 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 695562005388 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 695562005389 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 695562005390 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 695562005391 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 695562005392 Walker A/P-loop; other site 695562005393 ATP binding site [chemical binding]; other site 695562005394 Q-loop/lid; other site 695562005395 ABC transporter signature motif; other site 695562005396 Walker B; other site 695562005397 D-loop; other site 695562005398 H-loop/switch region; other site 695562005399 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 695562005400 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 695562005401 FtsX-like permease family; Region: FtsX; pfam02687 695562005402 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 695562005403 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 695562005404 FtsX-like permease family; Region: FtsX; pfam02687 695562005405 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 695562005406 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 695562005407 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 695562005408 active site 695562005409 Bacterial surface layer protein; Region: SLAP; pfam03217 695562005410 Protein of unknown function (DUF975); Region: DUF975; pfam06161 695562005411 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 695562005412 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 695562005413 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 695562005414 Walker A/P-loop; other site 695562005415 ATP binding site [chemical binding]; other site 695562005416 Q-loop/lid; other site 695562005417 ABC transporter signature motif; other site 695562005418 Walker B; other site 695562005419 D-loop; other site 695562005420 H-loop/switch region; other site 695562005421 potential frameshift: common BLAST hit: gi|315039223|ref|YP_004032791.1| Lactococcin A ABC transporter, ATP binding protein 695562005422 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 695562005423 active site 695562005424 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 695562005425 Beta-lactamase; Region: Beta-lactamase; pfam00144 695562005426 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 695562005427 DltD N-terminal region; Region: DltD_N; pfam04915 695562005428 DltD central region; Region: DltD_M; pfam04918 695562005429 DltD C-terminal region; Region: DltD_C; pfam04914 695562005430 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 695562005431 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 695562005432 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 695562005433 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 695562005434 acyl-activating enzyme (AAE) consensus motif; other site 695562005435 AMP binding site [chemical binding]; other site 695562005436 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 695562005437 FOG: CBS domain [General function prediction only]; Region: COG0517 695562005438 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 695562005439 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 695562005440 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 695562005441 Soluble P-type ATPase [General function prediction only]; Region: COG4087 695562005442 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 695562005443 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 695562005444 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 695562005445 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 695562005446 Probable transposase; Region: OrfB_IS605; pfam01385 695562005447 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 695562005448 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 695562005449 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 695562005450 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 695562005451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 695562005452 Walker A/P-loop; other site 695562005453 ATP binding site [chemical binding]; other site 695562005454 Q-loop/lid; other site 695562005455 ABC transporter signature motif; other site 695562005456 Walker B; other site 695562005457 D-loop; other site 695562005458 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 695562005459 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 695562005460 non-specific DNA binding site [nucleotide binding]; other site 695562005461 salt bridge; other site 695562005462 sequence-specific DNA binding site [nucleotide binding]; other site 695562005463 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 695562005464 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 695562005465 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 695562005466 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 695562005467 non-specific DNA binding site [nucleotide binding]; other site 695562005468 salt bridge; other site 695562005469 sequence-specific DNA binding site [nucleotide binding]; other site 695562005470 CAAX protease self-immunity; Region: Abi; pfam02517 695562005471 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 695562005472 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 695562005473 putative active site [active] 695562005474 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 695562005475 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 695562005476 Walker A/P-loop; other site 695562005477 ATP binding site [chemical binding]; other site 695562005478 Q-loop/lid; other site 695562005479 ABC transporter signature motif; other site 695562005480 Walker B; other site 695562005481 D-loop; other site 695562005482 H-loop/switch region; other site 695562005483 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 695562005484 FtsX-like permease family; Region: FtsX; pfam02687 695562005485 Predicted membrane protein [Function unknown]; Region: COG4684 695562005486 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 695562005487 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 695562005488 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 695562005489 ligand binding site [chemical binding]; other site 695562005490 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 695562005491 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 695562005492 active site 695562005493 catalytic tetrad [active] 695562005494 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 695562005495 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 695562005496 active site 695562005497 trimer interface [polypeptide binding]; other site 695562005498 allosteric site; other site 695562005499 active site lid [active] 695562005500 hexamer (dimer of trimers) interface [polypeptide binding]; other site 695562005501 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 695562005502 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 695562005503 Substrate-binding site [chemical binding]; other site 695562005504 Substrate specificity [chemical binding]; other site 695562005505 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 695562005506 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 695562005507 Substrate-binding site [chemical binding]; other site 695562005508 Substrate specificity [chemical binding]; other site 695562005509 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 695562005510 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 695562005511 active site 695562005512 motif I; other site 695562005513 motif II; other site 695562005514 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 695562005515 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 695562005516 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 695562005517 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 695562005518 DNA binding residues [nucleotide binding] 695562005519 dimer interface [polypeptide binding]; other site 695562005520 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 695562005521 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 695562005522 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 695562005523 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 695562005524 peptide binding site [polypeptide binding]; other site 695562005525 CAAX protease self-immunity; Region: Abi; pfam02517 695562005526 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 695562005527 Penicillinase repressor; Region: Pencillinase_R; pfam03965 695562005528 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 695562005529 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 695562005530 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 695562005531 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 695562005532 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 695562005533 Uncharacterized conserved protein [Function unknown]; Region: COG1434 695562005534 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 695562005535 putative active site [active] 695562005536 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 695562005537 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 695562005538 ligand binding site [chemical binding]; other site 695562005539 flexible hinge region; other site 695562005540 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 695562005541 putative switch regulator; other site 695562005542 non-specific DNA interactions [nucleotide binding]; other site 695562005543 DNA binding site [nucleotide binding] 695562005544 sequence specific DNA binding site [nucleotide binding]; other site 695562005545 putative cAMP binding site [chemical binding]; other site 695562005546 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 695562005547 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 695562005548 Cl- selectivity filter; other site 695562005549 Cl- binding residues [ion binding]; other site 695562005550 pore gating glutamate residue; other site 695562005551 dimer interface [polypeptide binding]; other site 695562005552 H+/Cl- coupling transport residue; other site 695562005553 TrkA-C domain; Region: TrkA_C; pfam02080 695562005554 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 695562005555 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 695562005556 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 695562005557 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 695562005558 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 695562005559 PYR/PP interface [polypeptide binding]; other site 695562005560 dimer interface [polypeptide binding]; other site 695562005561 tetramer interface [polypeptide binding]; other site 695562005562 TPP binding site [chemical binding]; other site 695562005563 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 695562005564 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 695562005565 TPP-binding site [chemical binding]; other site 695562005566 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 695562005567 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 695562005568 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 695562005569 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 695562005570 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 695562005571 trmE is a tRNA modification GTPase; Region: trmE; cd04164 695562005572 G1 box; other site 695562005573 GTP/Mg2+ binding site [chemical binding]; other site 695562005574 Switch I region; other site 695562005575 G2 box; other site 695562005576 Switch II region; other site 695562005577 G3 box; other site 695562005578 G4 box; other site 695562005579 G5 box; other site 695562005580 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 695562005581 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 695562005582 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 695562005583 ribonuclease P; Reviewed; Region: rnpA; PRK00499 695562005584 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 695562005585 Transposase, Mutator family; Region: Transposase_mut; pfam00872 695562005586 MULE transposase domain; Region: MULE; pfam10551 695562005587 CAAX protease self-immunity; Region: Abi; pfam02517 695562005588 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 695562005589 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 695562005590 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 695562005591 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 695562005592 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 695562005593 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 695562005594 Bacterial surface layer protein; Region: SLAP; pfam03217 695562005595 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 695562005596 potential frameshift: common BLAST hit: gi|325956743|ref|YP_004292155.1| transposase 695562005597 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 695562005598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 695562005599 S-adenosylmethionine binding site [chemical binding]; other site 695562005600 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 695562005601 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 695562005602 HsdM N-terminal domain; Region: HsdM_N; pfam12161 695562005603 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 695562005604 Methyltransferase domain; Region: Methyltransf_26; pfam13659 695562005605 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 695562005606 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 695562005607 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 695562005608 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 695562005609 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 695562005610 ATP binding site [chemical binding]; other site 695562005611 putative Mg++ binding site [ion binding]; other site 695562005612 Helix-turn-helix domain; Region: HTH_38; pfam13936 695562005613 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 695562005614 DNA-binding interface [nucleotide binding]; DNA binding site 695562005615 Integrase core domain; Region: rve; pfam00665 695562005616 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 695562005617 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 695562005618 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 695562005619 P-loop; other site 695562005620 Magnesium ion binding site [ion binding]; other site 695562005621 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 695562005622 Magnesium ion binding site [ion binding]; other site 695562005623 PIF1-like helicase; Region: PIF1; pfam05970 695562005624 AAA domain; Region: AAA_30; pfam13604 695562005625 Family description; Region: UvrD_C_2; pfam13538 695562005626 Initiator Replication protein; Region: Rep_3; pfam01051 695562005627 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 695562005628 Mrr N-terminal domain; Region: Mrr_N; pfam14338 695562005629 Restriction endonuclease; Region: Mrr_cat; pfam04471 695562005630 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 695562005631 dimer interface [polypeptide binding]; other site 695562005632 FMN binding site [chemical binding]; other site 695562005633 hypothetical protein; Provisional; Region: PRK06194 695562005634 classical (c) SDRs; Region: SDR_c; cd05233 695562005635 NAD(P) binding site [chemical binding]; other site 695562005636 active site 695562005637 hypothetical protein; Provisional; Region: PRK06194 695562005638 classical (c) SDRs; Region: SDR_c; cd05233 695562005639 NAD(P) binding site [chemical binding]; other site 695562005640 active site 695562005641 potential frameshift: common BLAST hit: gi|315038921|ref|YP_004032489.1| IS4 family transposase 695562005642 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 695562005643 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 695562005644 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 695562005645 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 695562005646 Walker A/P-loop; other site 695562005647 Walker A/P-loop; other site 695562005648 ATP binding site [chemical binding]; other site 695562005649 ATP binding site [chemical binding]; other site 695562005650 Q-loop/lid; other site 695562005651 ABC transporter signature motif; other site 695562005652 Walker B; other site 695562005653 D-loop; other site 695562005654 H-loop/switch region; other site 695562005655 Integrase core domain; Region: rve; pfam00665 695562005656 Transcriptional regulator [Transcription]; Region: LysR; COG0583 695562005657 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 695562005658 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 695562005659 dimerization interface [polypeptide binding]; other site 695562005660 FAD binding domain; Region: FAD_binding_2; pfam00890 695562005661 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 695562005662 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 695562005663 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 695562005664 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 695562005665 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 695562005666 catalytic residues [active] 695562005667 catalytic nucleophile [active] 695562005668 Presynaptic Site I dimer interface [polypeptide binding]; other site 695562005669 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 695562005670 Synaptic Flat tetramer interface [polypeptide binding]; other site 695562005671 Synaptic Site I dimer interface [polypeptide binding]; other site 695562005672 DNA binding site [nucleotide binding] 695562005673 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 695562005674 potential frameshift: common BLAST hit: gi|325956749|ref|YP_004292161.1| cytidine deaminase 695562005675 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 695562005676 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 695562005677 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 695562005678 nudix motif; other site 695562005679 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 695562005680 hypothetical protein; Provisional; Region: PRK06762 695562005681 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Sulfolobus solfataricus (Ss) and its homologs from archaea and bacteria; Region: NTP-PPase_SsMazG; cd11535 695562005682 metal binding site [ion binding]; metal-binding site 695562005683 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 695562005684 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 695562005685 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 695562005686 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 695562005687 Transposase, Mutator family; Region: Transposase_mut; pfam00872 695562005688 MULE transposase domain; Region: MULE; pfam10551 695562005689 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 695562005690 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 695562005691 G1 box; other site 695562005692 putative GEF interaction site [polypeptide binding]; other site 695562005693 GTP/Mg2+ binding site [chemical binding]; other site 695562005694 Switch I region; other site 695562005695 G2 box; other site 695562005696 G3 box; other site 695562005697 Switch II region; other site 695562005698 G4 box; other site 695562005699 G5 box; other site 695562005700 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 695562005701 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 695562005702 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 695562005703 Bacterial surface layer protein; Region: SLAP; pfam03217 695562005704 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 695562005705 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 695562005706 active site 695562005707 DNA binding site [nucleotide binding] 695562005708 Int/Topo IB signature motif; other site 695562005709 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 695562005710 Penicillinase repressor; Region: Pencillinase_R; pfam03965 695562005711 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 695562005712 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 695562005713 Soluble P-type ATPase [General function prediction only]; Region: COG4087 695562005714 potential frameshift: common BLAST hit: gi|295692042|ref|YP_003600652.1| cadmium resistance transporter 695562005715 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 695562005716 PemK-like protein; Region: PemK; pfam02452 695562005717 Integrase core domain; Region: rve; pfam00665 695562005718 Integrase core domain; Region: rve_2; pfam13333 695562005719 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 695562005720 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 695562005721 NAD(P) binding site [chemical binding]; other site 695562005722 Transposase, Mutator family; Region: Transposase_mut; pfam00872 695562005723 MULE transposase domain; Region: MULE; pfam10551 695562005724 Transcriptional regulator [Transcription]; Region: LysR; COG0583 695562005725 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 695562005726 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 695562005727 dimerization interface [polypeptide binding]; other site 695562005728 hypothetical protein; Validated; Region: PRK07121 695562005729 Predicted oxidoreductase [General function prediction only]; Region: COG3573 695562005730 FMN-binding domain; Region: FMN_bind; pfam04205