-- dump date 20140619_122512 -- class Genbank::misc_feature -- table misc_feature_note -- id note 387344000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 387344000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 387344000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 387344000004 Walker A motif; other site 387344000005 ATP binding site [chemical binding]; other site 387344000006 Walker B motif; other site 387344000007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 387344000008 arginine finger; other site 387344000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 387344000010 DnaA box-binding interface [nucleotide binding]; other site 387344000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 387344000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 387344000013 putative DNA binding surface [nucleotide binding]; other site 387344000014 dimer interface [polypeptide binding]; other site 387344000015 beta-clamp/clamp loader binding surface; other site 387344000016 beta-clamp/translesion DNA polymerase binding surface; other site 387344000017 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 387344000018 recombination protein F; Reviewed; Region: recF; PRK00064 387344000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 387344000020 Walker A/P-loop; other site 387344000021 ATP binding site [chemical binding]; other site 387344000022 Q-loop/lid; other site 387344000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 387344000024 ABC transporter signature motif; other site 387344000025 Walker B; other site 387344000026 D-loop; other site 387344000027 H-loop/switch region; other site 387344000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 387344000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 387344000030 Mg2+ binding site [ion binding]; other site 387344000031 G-X-G motif; other site 387344000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 387344000033 anchoring element; other site 387344000034 dimer interface [polypeptide binding]; other site 387344000035 ATP binding site [chemical binding]; other site 387344000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 387344000037 active site 387344000038 putative metal-binding site [ion binding]; other site 387344000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 387344000040 DNA gyrase subunit A; Validated; Region: PRK05560 387344000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 387344000042 CAP-like domain; other site 387344000043 active site 387344000044 primary dimer interface [polypeptide binding]; other site 387344000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 387344000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 387344000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 387344000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 387344000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 387344000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 387344000051 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 387344000052 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 387344000053 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 387344000054 dimer interface [polypeptide binding]; other site 387344000055 ssDNA binding site [nucleotide binding]; other site 387344000056 tetramer (dimer of dimers) interface [polypeptide binding]; other site 387344000057 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 387344000058 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 387344000059 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 387344000060 Amidohydrolase; Region: Amidohydro_4; pfam13147 387344000061 active site 387344000062 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 387344000063 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 387344000064 peptide binding site [polypeptide binding]; other site 387344000065 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 387344000066 Amidohydrolase; Region: Amidohydro_4; pfam13147 387344000067 active site 387344000068 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 387344000069 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 387344000070 peptide binding site [polypeptide binding]; other site 387344000071 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 387344000072 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 387344000073 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 387344000074 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 387344000075 DHH family; Region: DHH; pfam01368 387344000076 DHHA1 domain; Region: DHHA1; pfam02272 387344000077 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 387344000078 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 387344000079 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 387344000080 replicative DNA helicase; Provisional; Region: PRK05748 387344000081 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 387344000082 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 387344000083 Walker A motif; other site 387344000084 ATP binding site [chemical binding]; other site 387344000085 Walker B motif; other site 387344000086 DNA binding loops [nucleotide binding] 387344000087 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 387344000088 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 387344000089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344000090 Major Facilitator Superfamily; Region: MFS_1; pfam07690 387344000091 putative substrate translocation pore; other site 387344000092 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 387344000093 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 387344000094 peptide binding site [polypeptide binding]; other site 387344000095 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 387344000096 active site 387344000097 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 387344000098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 387344000099 active site 387344000100 phosphorylation site [posttranslational modification] 387344000101 intermolecular recognition site; other site 387344000102 dimerization interface [polypeptide binding]; other site 387344000103 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 387344000104 DNA binding site [nucleotide binding] 387344000105 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 387344000106 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 387344000107 dimerization interface [polypeptide binding]; other site 387344000108 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 387344000109 putative active site [active] 387344000110 heme pocket [chemical binding]; other site 387344000111 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 387344000112 dimer interface [polypeptide binding]; other site 387344000113 phosphorylation site [posttranslational modification] 387344000114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 387344000115 ATP binding site [chemical binding]; other site 387344000116 Mg2+ binding site [ion binding]; other site 387344000117 G-X-G motif; other site 387344000118 YycH protein; Region: YycH; pfam07435 387344000119 YycH protein; Region: YycI; pfam09648 387344000120 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 387344000121 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 387344000122 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 387344000123 protein binding site [polypeptide binding]; other site 387344000124 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 387344000125 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 387344000126 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 387344000127 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 387344000128 active site 387344000129 metal binding site [ion binding]; metal-binding site 387344000130 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 387344000131 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 387344000132 Coenzyme A binding pocket [chemical binding]; other site 387344000133 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 387344000134 Helix-turn-helix domain; Region: HTH_38; pfam13936 387344000135 Integrase core domain; Region: rve; pfam00665 387344000136 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 387344000137 DNA adenine methylase (dam); Region: dam; TIGR00571 387344000138 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 387344000139 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 387344000140 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 387344000141 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 387344000142 Helix-turn-helix domain; Region: HTH_38; pfam13936 387344000143 Integrase core domain; Region: rve; pfam00665 387344000144 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 387344000145 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 387344000146 Helix-turn-helix domain; Region: HTH_38; pfam13936 387344000147 Integrase core domain; Region: rve; pfam00665 387344000148 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 387344000149 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 387344000150 substrate binding pocket [chemical binding]; other site 387344000151 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 387344000152 maltose O-acetyltransferase; Provisional; Region: PRK10092 387344000153 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 387344000154 active site 387344000155 substrate binding site [chemical binding]; other site 387344000156 trimer interface [polypeptide binding]; other site 387344000157 CoA binding site [chemical binding]; other site 387344000158 Cadmium resistance transporter; Region: Cad; pfam03596 387344000159 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 387344000160 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 387344000161 Predicted membrane protein [Function unknown]; Region: COG2246 387344000162 GtrA-like protein; Region: GtrA; pfam04138 387344000163 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 387344000164 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 387344000165 peptide binding site [polypeptide binding]; other site 387344000166 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 387344000167 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 387344000168 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 387344000169 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 387344000170 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 387344000171 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 387344000172 HicB family; Region: HicB; pfam05534 387344000173 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 387344000174 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 387344000175 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 387344000176 CoenzymeA binding site [chemical binding]; other site 387344000177 subunit interaction site [polypeptide binding]; other site 387344000178 PHB binding site; other site 387344000179 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 387344000180 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 387344000181 substrate binding site [chemical binding]; other site 387344000182 oxyanion hole (OAH) forming residues; other site 387344000183 trimer interface [polypeptide binding]; other site 387344000184 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 387344000185 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 387344000186 acyl-activating enzyme (AAE) consensus motif; other site 387344000187 putative AMP binding site [chemical binding]; other site 387344000188 putative active site [active] 387344000189 putative CoA binding site [chemical binding]; other site 387344000190 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 387344000191 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 387344000192 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 387344000193 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 387344000194 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 387344000195 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 387344000196 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 387344000197 dimer interface [polypeptide binding]; other site 387344000198 putative anticodon binding site; other site 387344000199 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 387344000200 motif 1; other site 387344000201 active site 387344000202 motif 2; other site 387344000203 motif 3; other site 387344000204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344000205 Major Facilitator Superfamily; Region: MFS_1; pfam07690 387344000206 putative substrate translocation pore; other site 387344000207 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 387344000208 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 387344000209 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 387344000210 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 387344000211 putative NAD(P) binding site [chemical binding]; other site 387344000212 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 387344000213 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 387344000214 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 387344000215 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 387344000216 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 387344000217 catalytic residue [active] 387344000218 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 387344000219 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 387344000220 HIGH motif; other site 387344000221 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 387344000222 active site 387344000223 KMSKS motif; other site 387344000224 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 387344000225 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 387344000226 peroxiredoxin; Region: AhpC; TIGR03137 387344000227 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 387344000228 dimer interface [polypeptide binding]; other site 387344000229 decamer (pentamer of dimers) interface [polypeptide binding]; other site 387344000230 catalytic triad [active] 387344000231 peroxidatic and resolving cysteines [active] 387344000232 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 387344000233 NADH(P)-binding; Region: NAD_binding_10; pfam13460 387344000234 NAD(P) binding site [chemical binding]; other site 387344000235 putative active site [active] 387344000236 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 387344000237 non-specific DNA binding site [nucleotide binding]; other site 387344000238 salt bridge; other site 387344000239 sequence-specific DNA binding site [nucleotide binding]; other site 387344000240 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 387344000241 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 387344000242 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 387344000243 Transcriptional regulators [Transcription]; Region: MarR; COG1846 387344000244 MarR family; Region: MarR_2; pfam12802 387344000245 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 387344000246 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 387344000247 Coenzyme A binding pocket [chemical binding]; other site 387344000248 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 387344000249 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 387344000250 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 387344000251 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 387344000252 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 387344000253 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 387344000254 active site 387344000255 catalytic tetrad [active] 387344000256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344000257 Major Facilitator Superfamily; Region: MFS_1; pfam07690 387344000258 putative substrate translocation pore; other site 387344000259 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 387344000260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344000261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344000262 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 387344000263 dimer interface [polypeptide binding]; other site 387344000264 FMN binding site [chemical binding]; other site 387344000265 NADPH bind site [chemical binding]; other site 387344000266 flavoprotein NrdI; Provisional; Region: PRK02551 387344000267 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 387344000268 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 387344000269 ABC transporter; Region: ABC_tran_2; pfam12848 387344000270 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 387344000271 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 387344000272 Major Facilitator Superfamily; Region: MFS_1; pfam07690 387344000273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344000274 putative substrate translocation pore; other site 387344000275 Uncharacterized conserved protein [Function unknown]; Region: COG5604 387344000276 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 387344000277 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 387344000278 NADP binding site [chemical binding]; other site 387344000279 homodimer interface [polypeptide binding]; other site 387344000280 active site 387344000281 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 387344000282 DNA binding site [nucleotide binding] 387344000283 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 387344000284 domain linker motif; other site 387344000285 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 387344000286 putative dimerization interface [polypeptide binding]; other site 387344000287 putative ligand binding site [chemical binding]; other site 387344000288 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 387344000289 Domain of unknown function DUF21; Region: DUF21; pfam01595 387344000290 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 387344000291 Transporter associated domain; Region: CorC_HlyC; smart01091 387344000292 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 387344000293 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 387344000294 putative dimer interface [polypeptide binding]; other site 387344000295 inner membrane transporter YjeM; Provisional; Region: PRK15238 387344000296 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 387344000297 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 387344000298 active site 387344000299 catalytic tetrad [active] 387344000300 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 387344000301 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 387344000302 Soluble P-type ATPase [General function prediction only]; Region: COG4087 387344000303 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 387344000304 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 387344000305 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 387344000306 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 387344000307 putative active site [active] 387344000308 catalytic site [active] 387344000309 putative metal binding site [ion binding]; other site 387344000310 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 387344000311 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 387344000312 putative catalytic cysteine [active] 387344000313 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 387344000314 putative active site [active] 387344000315 metal binding site [ion binding]; metal-binding site 387344000316 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 387344000317 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 387344000318 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 387344000319 Helix-turn-helix domain; Region: HTH_38; pfam13936 387344000320 Integrase core domain; Region: rve; pfam00665 387344000321 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 387344000322 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 387344000323 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 387344000324 MucBP domain; Region: MucBP; pfam06458 387344000325 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 387344000326 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 387344000327 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 387344000328 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 387344000329 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 387344000330 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 387344000331 substrate binding site [chemical binding]; other site 387344000332 ATP binding site [chemical binding]; other site 387344000333 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 387344000334 propionate/acetate kinase; Provisional; Region: PRK12379 387344000335 3D domain; Region: 3D; cl01439 387344000336 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 387344000337 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 387344000338 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 387344000339 Walker A/P-loop; other site 387344000340 ATP binding site [chemical binding]; other site 387344000341 Q-loop/lid; other site 387344000342 ABC transporter signature motif; other site 387344000343 Walker B; other site 387344000344 D-loop; other site 387344000345 H-loop/switch region; other site 387344000346 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 387344000347 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 387344000348 Zn2+ binding site [ion binding]; other site 387344000349 Mg2+ binding site [ion binding]; other site 387344000350 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 387344000351 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 387344000352 Glucuronate isomerase; Region: UxaC; pfam02614 387344000353 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 387344000354 MFS/sugar transport protein; Region: MFS_2; pfam13347 387344000355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344000356 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 387344000357 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 387344000358 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 387344000359 putative active site [active] 387344000360 putative catalytic site [active] 387344000361 beta-D-glucuronidase; Provisional; Region: PRK10150 387344000362 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 387344000363 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 387344000364 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 387344000365 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 387344000366 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 387344000367 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 387344000368 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 387344000369 active site 387344000370 catalytic residues [active] 387344000371 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 387344000372 catalytic core [active] 387344000373 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_12; cd12177 387344000374 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 387344000375 putative ligand binding site [chemical binding]; other site 387344000376 putative NAD binding site [chemical binding]; other site 387344000377 catalytic site [active] 387344000378 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 387344000379 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 387344000380 N- and C-terminal domain interface [polypeptide binding]; other site 387344000381 active site 387344000382 catalytic site [active] 387344000383 metal binding site [ion binding]; metal-binding site 387344000384 carbohydrate binding site [chemical binding]; other site 387344000385 ATP binding site [chemical binding]; other site 387344000386 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 387344000387 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 387344000388 Transcriptional regulators [Transcription]; Region: GntR; COG1802 387344000389 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 387344000390 DNA-binding site [nucleotide binding]; DNA binding site 387344000391 FCD domain; Region: FCD; pfam07729 387344000392 mannonate dehydratase; Provisional; Region: PRK03906 387344000393 mannonate dehydratase; Region: uxuA; TIGR00695 387344000394 Transcriptional regulators [Transcription]; Region: PurR; COG1609 387344000395 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 387344000396 DNA binding site [nucleotide binding] 387344000397 domain linker motif; other site 387344000398 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 387344000399 ligand binding site [chemical binding]; other site 387344000400 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 387344000401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344000402 putative substrate translocation pore; other site 387344000403 Glucuronate isomerase; Region: UxaC; pfam02614 387344000404 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 387344000405 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 387344000406 Helix-turn-helix domain; Region: HTH_38; pfam13936 387344000407 Integrase core domain; Region: rve; pfam00665 387344000408 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 387344000409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344000410 Major Facilitator Superfamily; Region: MFS_1; pfam07690 387344000411 putative substrate translocation pore; other site 387344000412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344000413 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 387344000414 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 387344000415 putative deacylase active site [active] 387344000416 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 387344000417 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 387344000418 DNA-binding site [nucleotide binding]; DNA binding site 387344000419 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 387344000420 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 387344000421 active site 387344000422 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 387344000423 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 387344000424 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 387344000425 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 387344000426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 387344000427 active site 387344000428 phosphorylation site [posttranslational modification] 387344000429 intermolecular recognition site; other site 387344000430 dimerization interface [polypeptide binding]; other site 387344000431 LytTr DNA-binding domain; Region: LytTR; pfam04397 387344000432 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 387344000433 ATP binding site [chemical binding]; other site 387344000434 Mg2+ binding site [ion binding]; other site 387344000435 G-X-G motif; other site 387344000436 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 387344000437 short chain dehydrogenase; Validated; Region: PRK07069 387344000438 NAD(P) binding site [chemical binding]; other site 387344000439 active site 387344000440 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 387344000441 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 387344000442 active site 387344000443 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 387344000444 Ligand Binding Site [chemical binding]; other site 387344000445 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 387344000446 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 387344000447 peptide binding site [polypeptide binding]; other site 387344000448 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 387344000449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 387344000450 dimer interface [polypeptide binding]; other site 387344000451 conserved gate region; other site 387344000452 putative PBP binding loops; other site 387344000453 ABC-ATPase subunit interface; other site 387344000454 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 387344000455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 387344000456 dimer interface [polypeptide binding]; other site 387344000457 conserved gate region; other site 387344000458 putative PBP binding loops; other site 387344000459 ABC-ATPase subunit interface; other site 387344000460 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 387344000461 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 387344000462 Walker A/P-loop; other site 387344000463 ATP binding site [chemical binding]; other site 387344000464 Q-loop/lid; other site 387344000465 ABC transporter signature motif; other site 387344000466 Walker B; other site 387344000467 D-loop; other site 387344000468 H-loop/switch region; other site 387344000469 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 387344000470 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 387344000471 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 387344000472 Walker A/P-loop; other site 387344000473 ATP binding site [chemical binding]; other site 387344000474 Q-loop/lid; other site 387344000475 ABC transporter signature motif; other site 387344000476 Walker B; other site 387344000477 D-loop; other site 387344000478 H-loop/switch region; other site 387344000479 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 387344000480 Predicted transcriptional regulator [Transcription]; Region: COG1959 387344000481 Transcriptional regulator; Region: Rrf2; pfam02082 387344000482 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 387344000483 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 387344000484 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 387344000485 xylose isomerase; Provisional; Region: PRK05474 387344000486 xylose isomerase; Region: xylose_isom_A; TIGR02630 387344000487 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 387344000488 N- and C-terminal domain interface [polypeptide binding]; other site 387344000489 D-xylulose kinase; Region: XylB; TIGR01312 387344000490 active site 387344000491 MgATP binding site [chemical binding]; other site 387344000492 catalytic site [active] 387344000493 metal binding site [ion binding]; metal-binding site 387344000494 xylulose binding site [chemical binding]; other site 387344000495 homodimer interface [polypeptide binding]; other site 387344000496 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 387344000497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344000498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344000499 acetoin reductase; Validated; Region: PRK08643 387344000500 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 387344000501 NAD binding site [chemical binding]; other site 387344000502 homotetramer interface [polypeptide binding]; other site 387344000503 homodimer interface [polypeptide binding]; other site 387344000504 active site 387344000505 substrate binding site [chemical binding]; other site 387344000506 Uncharacterized conserved protein [Function unknown]; Region: COG5646 387344000507 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 387344000508 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 387344000509 Ligand Binding Site [chemical binding]; other site 387344000510 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 387344000511 substrate binding site [chemical binding]; other site 387344000512 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 387344000513 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 387344000514 metal binding site [ion binding]; metal-binding site 387344000515 dimer interface [polypeptide binding]; other site 387344000516 Ion transport protein; Region: Ion_trans; pfam00520 387344000517 Ion channel; Region: Ion_trans_2; pfam07885 387344000518 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 387344000519 Transposase; Region: DDE_Tnp_ISL3; pfam01610 387344000520 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 387344000521 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 387344000522 active site 387344000523 catalytic tetrad [active] 387344000524 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 387344000525 Coenzyme A binding pocket [chemical binding]; other site 387344000526 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 387344000527 Membrane transport protein; Region: Mem_trans; cl09117 387344000528 (R)-2-Hydroxyglutarate Dehydrogenase and related dehydrogenases, NAD-binding and catalytic domains; Region: HGDH_like; cd12184 387344000529 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 387344000530 putative homodimer interface [polypeptide binding]; other site 387344000531 putative ligand binding site [chemical binding]; other site 387344000532 putative NAD binding site [chemical binding]; other site 387344000533 catalytic site [active] 387344000534 sensory histidine kinase DcuS; Provisional; Region: PRK11086 387344000535 PAS domain; Region: PAS; smart00091 387344000536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 387344000537 ATP binding site [chemical binding]; other site 387344000538 Mg2+ binding site [ion binding]; other site 387344000539 G-X-G motif; other site 387344000540 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 387344000541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 387344000542 active site 387344000543 phosphorylation site [posttranslational modification] 387344000544 intermolecular recognition site; other site 387344000545 dimerization interface [polypeptide binding]; other site 387344000546 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 387344000547 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 387344000548 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 387344000549 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 387344000550 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 387344000551 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 387344000552 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 387344000553 Double zinc ribbon; Region: DZR; pfam12773 387344000554 Predicted membrane protein [Function unknown]; Region: COG4640 387344000555 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 387344000556 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 387344000557 nudix motif; other site 387344000558 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 387344000559 Predicted transcriptional regulators [Transcription]; Region: COG1695 387344000560 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 387344000561 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 387344000562 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 387344000563 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 387344000564 NADP binding site [chemical binding]; other site 387344000565 putative substrate binding site [chemical binding]; other site 387344000566 active site 387344000567 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 387344000568 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 387344000569 MarR family; Region: MarR; pfam01047 387344000570 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 387344000571 Cadmium resistance transporter; Region: Cad; pfam03596 387344000572 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 387344000573 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 387344000574 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 387344000575 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 387344000576 Ligand Binding Site [chemical binding]; other site 387344000577 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 387344000578 Helix-turn-helix domain; Region: HTH_38; pfam13936 387344000579 Integrase core domain; Region: rve; pfam00665 387344000580 manganese transport protein MntH; Reviewed; Region: PRK00701 387344000581 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 387344000582 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 387344000583 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 387344000584 active site 387344000585 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 387344000586 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 387344000587 GDP-binding site [chemical binding]; other site 387344000588 ACT binding site; other site 387344000589 IMP binding site; other site 387344000590 adenylosuccinate lyase; Provisional; Region: PRK07492 387344000591 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 387344000592 tetramer interface [polypeptide binding]; other site 387344000593 active site 387344000594 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 387344000595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 387344000596 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 387344000597 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 387344000598 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 387344000599 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 387344000600 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 387344000601 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 387344000602 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 387344000603 peptidase domain interface [polypeptide binding]; other site 387344000604 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 387344000605 active site 387344000606 catalytic triad [active] 387344000607 calcium binding site [ion binding]; other site 387344000608 Predicted membrane protein [Function unknown]; Region: COG2364 387344000609 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 387344000610 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 387344000611 catalytic triad [active] 387344000612 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 387344000613 endonuclease III; Region: ENDO3c; smart00478 387344000614 minor groove reading motif; other site 387344000615 helix-hairpin-helix signature motif; other site 387344000616 substrate binding pocket [chemical binding]; other site 387344000617 active site 387344000618 glycerol kinase; Provisional; Region: glpK; PRK00047 387344000619 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 387344000620 N- and C-terminal domain interface [polypeptide binding]; other site 387344000621 active site 387344000622 MgATP binding site [chemical binding]; other site 387344000623 catalytic site [active] 387344000624 metal binding site [ion binding]; metal-binding site 387344000625 glycerol binding site [chemical binding]; other site 387344000626 homotetramer interface [polypeptide binding]; other site 387344000627 homodimer interface [polypeptide binding]; other site 387344000628 FBP binding site [chemical binding]; other site 387344000629 protein IIAGlc interface [polypeptide binding]; other site 387344000630 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 387344000631 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 387344000632 NlpC/P60 family; Region: NLPC_P60; cl17555 387344000633 SH3-like domain; Region: SH3_8; pfam13457 387344000634 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 387344000635 putative active site [active] 387344000636 Isochorismatase family; Region: Isochorismatase; pfam00857 387344000637 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 387344000638 catalytic triad [active] 387344000639 conserved cis-peptide bond; other site 387344000640 Predicted transcriptional regulators [Transcription]; Region: COG1695 387344000641 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 387344000642 Predicted membrane protein [Function unknown]; Region: COG4709 387344000643 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 387344000644 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 387344000645 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 387344000646 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 387344000647 FMN binding site [chemical binding]; other site 387344000648 active site 387344000649 catalytic residues [active] 387344000650 substrate binding site [chemical binding]; other site 387344000651 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 387344000652 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 387344000653 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 387344000654 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 387344000655 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 387344000656 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 387344000657 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 387344000658 putative transport protein YifK; Provisional; Region: PRK10746 387344000659 WxL domain surface cell wall-binding; Region: WxL; pfam13731 387344000660 legume lectins; Region: lectin_L-type; cl14058 387344000661 homotetramer interaction site [polypeptide binding]; other site 387344000662 carbohydrate binding site [chemical binding]; other site 387344000663 metal binding site [ion binding]; metal-binding site 387344000664 WxL domain surface cell wall-binding; Region: WxL; pfam13731 387344000665 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 387344000666 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 387344000667 metal binding site [ion binding]; metal-binding site 387344000668 dimer interface [polypeptide binding]; other site 387344000669 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 387344000670 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 387344000671 NAD binding site [chemical binding]; other site 387344000672 substrate binding site [chemical binding]; other site 387344000673 catalytic Zn binding site [ion binding]; other site 387344000674 tetramer interface [polypeptide binding]; other site 387344000675 structural Zn binding site [ion binding]; other site 387344000676 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 387344000677 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 387344000678 putative DNA binding site [nucleotide binding]; other site 387344000679 putative Zn2+ binding site [ion binding]; other site 387344000680 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 387344000681 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 387344000682 Walker A/P-loop; other site 387344000683 ATP binding site [chemical binding]; other site 387344000684 Q-loop/lid; other site 387344000685 ABC transporter signature motif; other site 387344000686 Walker B; other site 387344000687 D-loop; other site 387344000688 H-loop/switch region; other site 387344000689 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 387344000690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 387344000691 ABC-ATPase subunit interface; other site 387344000692 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 387344000693 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 387344000694 substrate binding site [chemical binding]; other site 387344000695 THF binding site; other site 387344000696 zinc-binding site [ion binding]; other site 387344000697 Predicted flavoprotein [General function prediction only]; Region: COG0431 387344000698 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 387344000699 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 387344000700 MarR family; Region: MarR_2; pfam12802 387344000701 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 387344000702 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 387344000703 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 387344000704 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 387344000705 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 387344000706 motif II; other site 387344000707 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 387344000708 Peptidase family C69; Region: Peptidase_C69; pfam03577 387344000709 maltose O-acetyltransferase; Provisional; Region: PRK10092 387344000710 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 387344000711 active site 387344000712 substrate binding site [chemical binding]; other site 387344000713 trimer interface [polypeptide binding]; other site 387344000714 CoA binding site [chemical binding]; other site 387344000715 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 387344000716 EamA-like transporter family; Region: EamA; pfam00892 387344000717 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 387344000718 EamA-like transporter family; Region: EamA; pfam00892 387344000719 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 387344000720 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 387344000721 Soluble P-type ATPase [General function prediction only]; Region: COG4087 387344000722 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 387344000723 Penicillinase repressor; Region: Pencillinase_R; pfam03965 387344000724 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 387344000725 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 387344000726 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 387344000727 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 387344000728 active site 387344000729 catalytic tetrad [active] 387344000730 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 387344000731 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 387344000732 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 387344000733 motif II; other site 387344000734 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 387344000735 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 387344000736 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 387344000737 putative active site [active] 387344000738 putative metal binding site [ion binding]; other site 387344000739 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 387344000740 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 387344000741 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 387344000742 active site 387344000743 Acyltransferase family; Region: Acyl_transf_3; pfam01757 387344000744 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 387344000745 catalytic triad [active] 387344000746 oxyanion hole [active] 387344000747 catalytic triad [active] 387344000748 myosin-cross-reactive antigen; Provisional; Region: PRK13977 387344000749 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 387344000750 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 387344000751 Catalytic site [active] 387344000752 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 387344000753 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 387344000754 active site 387344000755 catalytic motif [active] 387344000756 Zn binding site [ion binding]; other site 387344000757 putative internal virion protein; Provisional; Region: PHA03415 387344000758 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 387344000759 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 387344000760 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 387344000761 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 387344000762 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 387344000763 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 387344000764 Walker A/P-loop; other site 387344000765 ATP binding site [chemical binding]; other site 387344000766 Q-loop/lid; other site 387344000767 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 387344000768 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 387344000769 ABC transporter signature motif; other site 387344000770 Walker B; other site 387344000771 D-loop; other site 387344000772 H-loop/switch region; other site 387344000773 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 387344000774 Walker A/P-loop; other site 387344000775 ATP binding site [chemical binding]; other site 387344000776 Q-loop/lid; other site 387344000777 ABC transporter signature motif; other site 387344000778 Walker B; other site 387344000779 D-loop; other site 387344000780 H-loop/switch region; other site 387344000781 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 387344000782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 387344000783 dimer interface [polypeptide binding]; other site 387344000784 conserved gate region; other site 387344000785 putative PBP binding loops; other site 387344000786 ABC-ATPase subunit interface; other site 387344000787 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 387344000788 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 387344000789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 387344000790 dimer interface [polypeptide binding]; other site 387344000791 conserved gate region; other site 387344000792 putative PBP binding loops; other site 387344000793 ABC-ATPase subunit interface; other site 387344000794 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 387344000795 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 387344000796 Walker A/P-loop; other site 387344000797 ATP binding site [chemical binding]; other site 387344000798 Q-loop/lid; other site 387344000799 ABC transporter signature motif; other site 387344000800 Walker B; other site 387344000801 D-loop; other site 387344000802 H-loop/switch region; other site 387344000803 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 387344000804 drug efflux system protein MdtG; Provisional; Region: PRK09874 387344000805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344000806 putative substrate translocation pore; other site 387344000807 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 387344000808 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 387344000809 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 387344000810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 387344000811 homodimer interface [polypeptide binding]; other site 387344000812 catalytic residue [active] 387344000813 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 387344000814 conserved hypothetical integral membrane protein; Region: TIGR03766 387344000815 conserved hypothetical integral membrane protein; Region: TIGR03766 387344000816 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 387344000817 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 387344000818 Ligand binding site; other site 387344000819 Putative Catalytic site; other site 387344000820 DXD motif; other site 387344000821 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 387344000822 active site 387344000823 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 387344000824 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 387344000825 Domain of unknown function DUF20; Region: UPF0118; pfam01594 387344000826 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 387344000827 FtsX-like permease family; Region: FtsX; pfam02687 387344000828 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 387344000829 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 387344000830 Walker A/P-loop; other site 387344000831 ATP binding site [chemical binding]; other site 387344000832 Q-loop/lid; other site 387344000833 ABC transporter signature motif; other site 387344000834 Walker B; other site 387344000835 D-loop; other site 387344000836 H-loop/switch region; other site 387344000837 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 387344000838 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 387344000839 Ca binding site [ion binding]; other site 387344000840 active site 387344000841 catalytic site [active] 387344000842 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 387344000843 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 387344000844 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 387344000845 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 387344000846 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 387344000847 Cl binding site [ion binding]; other site 387344000848 oligomer interface [polypeptide binding]; other site 387344000849 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 387344000850 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 387344000851 PYR/PP interface [polypeptide binding]; other site 387344000852 tetramer interface [polypeptide binding]; other site 387344000853 dimer interface [polypeptide binding]; other site 387344000854 TPP binding site [chemical binding]; other site 387344000855 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 387344000856 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 387344000857 TPP-binding site [chemical binding]; other site 387344000858 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 387344000859 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 387344000860 dimer interface [polypeptide binding]; other site 387344000861 phosphorylation site [posttranslational modification] 387344000862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 387344000863 ATP binding site [chemical binding]; other site 387344000864 Mg2+ binding site [ion binding]; other site 387344000865 G-X-G motif; other site 387344000866 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 387344000867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 387344000868 active site 387344000869 phosphorylation site [posttranslational modification] 387344000870 intermolecular recognition site; other site 387344000871 dimerization interface [polypeptide binding]; other site 387344000872 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 387344000873 DNA binding site [nucleotide binding] 387344000874 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 387344000875 NADH(P)-binding; Region: NAD_binding_10; pfam13460 387344000876 NAD(P) binding site [chemical binding]; other site 387344000877 putative active site [active] 387344000878 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 387344000879 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 387344000880 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 387344000881 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 387344000882 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 387344000883 DNA binding site [nucleotide binding] 387344000884 active site 387344000885 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 387344000886 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 387344000887 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 387344000888 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 387344000889 NAD(P) binding site [chemical binding]; other site 387344000890 catalytic residues [active] 387344000891 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 387344000892 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 387344000893 active site 387344000894 intersubunit interface [polypeptide binding]; other site 387344000895 catalytic residue [active] 387344000896 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 387344000897 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 387344000898 substrate binding site [chemical binding]; other site 387344000899 ATP binding site [chemical binding]; other site 387344000900 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 387344000901 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 387344000902 NADP binding site [chemical binding]; other site 387344000903 homodimer interface [polypeptide binding]; other site 387344000904 active site 387344000905 Transcriptional regulator [Transcription]; Region: IclR; COG1414 387344000906 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 387344000907 Bacterial transcriptional regulator; Region: IclR; pfam01614 387344000908 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 387344000909 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 387344000910 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 387344000911 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 387344000912 NAD(P) binding site [chemical binding]; other site 387344000913 active site 387344000914 manganese transport protein MntH; Reviewed; Region: PRK00701 387344000915 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 387344000916 EDD domain protein, DegV family; Region: DegV; TIGR00762 387344000917 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 387344000918 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 387344000919 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 387344000920 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 387344000921 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 387344000922 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 387344000923 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 387344000924 catalytic residues [active] 387344000925 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 387344000926 putative homodimer interface [polypeptide binding]; other site 387344000927 putative homotetramer interface [polypeptide binding]; other site 387344000928 putative metal binding site [ion binding]; other site 387344000929 putative homodimer-homodimer interface [polypeptide binding]; other site 387344000930 putative allosteric switch controlling residues; other site 387344000931 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 387344000932 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 387344000933 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 387344000934 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 387344000935 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 387344000936 S-ribosylhomocysteinase; Provisional; Region: PRK02260 387344000937 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 387344000938 FAD binding pocket [chemical binding]; other site 387344000939 conserved FAD binding motif [chemical binding]; other site 387344000940 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 387344000941 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 387344000942 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 387344000943 Transcriptional regulator [Transcription]; Region: LysR; COG0583 387344000944 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 387344000945 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 387344000946 dimerization interface [polypeptide binding]; other site 387344000947 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 387344000948 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 387344000949 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 387344000950 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 387344000951 homotetramer interface [polypeptide binding]; other site 387344000952 NAD binding site [chemical binding]; other site 387344000953 homodimer interface [polypeptide binding]; other site 387344000954 active site 387344000955 drug efflux system protein MdtG; Provisional; Region: PRK09874 387344000956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344000957 putative substrate translocation pore; other site 387344000958 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 387344000959 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 387344000960 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 387344000961 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 387344000962 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 387344000963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 387344000964 active site 387344000965 phosphorylation site [posttranslational modification] 387344000966 intermolecular recognition site; other site 387344000967 dimerization interface [polypeptide binding]; other site 387344000968 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 387344000969 DNA binding site [nucleotide binding] 387344000970 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 387344000971 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 387344000972 dimer interface [polypeptide binding]; other site 387344000973 phosphorylation site [posttranslational modification] 387344000974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 387344000975 ATP binding site [chemical binding]; other site 387344000976 Mg2+ binding site [ion binding]; other site 387344000977 G-X-G motif; other site 387344000978 Transcriptional regulators [Transcription]; Region: PurR; COG1609 387344000979 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 387344000980 DNA binding site [nucleotide binding] 387344000981 domain linker motif; other site 387344000982 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 387344000983 putative dimerization interface [polypeptide binding]; other site 387344000984 putative ligand binding site [chemical binding]; other site 387344000985 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 387344000986 Major Facilitator Superfamily; Region: MFS_1; pfam07690 387344000987 maltose phosphorylase; Provisional; Region: PRK13807 387344000988 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 387344000989 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 387344000990 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 387344000991 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 387344000992 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 387344000993 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 387344000994 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 387344000995 Transcriptional regulators [Transcription]; Region: MarR; COG1846 387344000996 MarR family; Region: MarR_2; pfam12802 387344000997 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 387344000998 putative catalytic residues [active] 387344000999 thiol/disulfide switch; other site 387344001000 ArsC family; Region: ArsC; pfam03960 387344001001 NlpC/P60 family; Region: NLPC_P60; pfam00877 387344001002 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 387344001003 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 387344001004 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 387344001005 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 387344001006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 387344001007 short chain dehydrogenase; Provisional; Region: PRK07041 387344001008 NAD(P) binding site [chemical binding]; other site 387344001009 active site 387344001010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344001011 putative substrate translocation pore; other site 387344001012 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 387344001013 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 387344001014 inhibitor binding site; inhibition site 387344001015 active site 387344001016 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 387344001017 Helix-turn-helix domain; Region: HTH_38; pfam13936 387344001018 Integrase core domain; Region: rve; pfam00665 387344001019 Cupin domain; Region: Cupin_2; pfam07883 387344001020 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 387344001021 Helix-turn-helix domain; Region: HTH_18; pfam12833 387344001022 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 387344001023 classical (c) SDRs; Region: SDR_c; cd05233 387344001024 NAD(P) binding site [chemical binding]; other site 387344001025 active site 387344001026 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 387344001027 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 387344001028 NAD(P) binding site [chemical binding]; other site 387344001029 active site 387344001030 Predicted transcriptional regulator [Transcription]; Region: COG1959 387344001031 Transcriptional regulator; Region: Rrf2; pfam02082 387344001032 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 387344001033 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 387344001034 Predicted transcriptional regulators [Transcription]; Region: COG1733 387344001035 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 387344001036 putative DNA binding site [nucleotide binding]; other site 387344001037 putative Zn2+ binding site [ion binding]; other site 387344001038 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 387344001039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344001040 putative substrate translocation pore; other site 387344001041 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 387344001042 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 387344001043 active site 387344001044 catalytic tetrad [active] 387344001045 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 387344001046 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 387344001047 Walker A/P-loop; other site 387344001048 ATP binding site [chemical binding]; other site 387344001049 Q-loop/lid; other site 387344001050 ABC transporter signature motif; other site 387344001051 Walker B; other site 387344001052 D-loop; other site 387344001053 H-loop/switch region; other site 387344001054 Predicted transcriptional regulators [Transcription]; Region: COG1725 387344001055 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 387344001056 DNA-binding site [nucleotide binding]; DNA binding site 387344001057 Collagen binding domain; Region: Collagen_bind; pfam05737 387344001058 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 387344001059 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 387344001060 Soluble P-type ATPase [General function prediction only]; Region: COG4087 387344001061 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 387344001062 multicopper oxidase; Provisional; Region: PRK10965 387344001063 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 387344001064 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 387344001065 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 387344001066 dimerization interface [polypeptide binding]; other site 387344001067 putative DNA binding site [nucleotide binding]; other site 387344001068 putative Zn2+ binding site [ion binding]; other site 387344001069 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 387344001070 Cadmium resistance transporter; Region: Cad; pfam03596 387344001071 Predicted membrane protein [Function unknown]; Region: COG2855 387344001072 Transcriptional regulator [Transcription]; Region: LysR; COG0583 387344001073 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 387344001074 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 387344001075 dimerization interface [polypeptide binding]; other site 387344001076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344001077 Major Facilitator Superfamily; Region: MFS_1; pfam07690 387344001078 putative substrate translocation pore; other site 387344001079 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 387344001080 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 387344001081 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 387344001082 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 387344001083 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 387344001084 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 387344001085 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 387344001086 ABC transporter; Region: ABC_tran_2; pfam12848 387344001087 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 387344001088 Protein of unknown function, DUF606; Region: DUF606; pfam04657 387344001089 Protein of unknown function, DUF606; Region: DUF606; pfam04657 387344001090 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 387344001091 active site 387344001092 dimerization interface [polypeptide binding]; other site 387344001093 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 387344001094 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 387344001095 B3/4 domain; Region: B3_4; pfam03483 387344001096 Protein of unknown function (DUF975); Region: DUF975; cl10504 387344001097 Predicted transcriptional regulators [Transcription]; Region: COG1725 387344001098 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 387344001099 DNA-binding site [nucleotide binding]; DNA binding site 387344001100 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 387344001101 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 387344001102 Walker A/P-loop; other site 387344001103 ATP binding site [chemical binding]; other site 387344001104 Q-loop/lid; other site 387344001105 ABC transporter signature motif; other site 387344001106 Walker B; other site 387344001107 D-loop; other site 387344001108 H-loop/switch region; other site 387344001109 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 387344001110 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 387344001111 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 387344001112 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 387344001113 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 387344001114 fructuronate transporter; Provisional; Region: PRK10034; cl15264 387344001115 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 387344001116 Predicted membrane protein [Function unknown]; Region: COG3428 387344001117 Bacterial PH domain; Region: DUF304; pfam03703 387344001118 Bacterial PH domain; Region: DUF304; pfam03703 387344001119 Bacterial PH domain; Region: DUF304; pfam03703 387344001120 Uncharacterized conserved protein [Function unknown]; Region: COG3402 387344001121 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 387344001122 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 387344001123 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 387344001124 Na binding site [ion binding]; other site 387344001125 Mga helix-turn-helix domain; Region: Mga; pfam05043 387344001126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 387344001127 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 387344001128 Transcriptional regulators [Transcription]; Region: MarR; COG1846 387344001129 MarR family; Region: MarR_2; pfam12802 387344001130 manganese transport protein MntH; Reviewed; Region: PRK00701 387344001131 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 387344001132 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 387344001133 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 387344001134 active site 387344001135 HIGH motif; other site 387344001136 dimer interface [polypeptide binding]; other site 387344001137 KMSKS motif; other site 387344001138 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 387344001139 RNA binding surface [nucleotide binding]; other site 387344001140 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 387344001141 nudix motif; other site 387344001142 Predicted membrane protein [Function unknown]; Region: COG2323 387344001143 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 387344001144 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 387344001145 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 387344001146 non-specific DNA binding site [nucleotide binding]; other site 387344001147 salt bridge; other site 387344001148 sequence-specific DNA binding site [nucleotide binding]; other site 387344001149 H+ Antiporter protein; Region: 2A0121; TIGR00900 387344001150 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 387344001151 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 387344001152 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 387344001153 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 387344001154 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 387344001155 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 387344001156 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 387344001157 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 387344001158 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 387344001159 substrate binding site [chemical binding]; other site 387344001160 ATP binding site [chemical binding]; other site 387344001161 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 387344001162 active site 387344001163 dimer interface [polypeptide binding]; other site 387344001164 magnesium binding site [ion binding]; other site 387344001165 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 387344001166 tetramer interface [polypeptide binding]; other site 387344001167 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 387344001168 active site 387344001169 Transcriptional regulators [Transcription]; Region: PurR; COG1609 387344001170 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 387344001171 DNA binding site [nucleotide binding] 387344001172 domain linker motif; other site 387344001173 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 387344001174 putative dimerization interface [polypeptide binding]; other site 387344001175 putative ligand binding site [chemical binding]; other site 387344001176 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 387344001177 Part of AAA domain; Region: AAA_19; pfam13245 387344001178 Family description; Region: UvrD_C_2; pfam13538 387344001179 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 387344001180 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 387344001181 active site 387344001182 HIGH motif; other site 387344001183 dimer interface [polypeptide binding]; other site 387344001184 KMSKS motif; other site 387344001185 exopolyphosphatase; Region: exo_poly_only; TIGR03706 387344001186 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 387344001187 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 387344001188 homodimer interface [polypeptide binding]; other site 387344001189 catalytic residues [active] 387344001190 NAD binding site [chemical binding]; other site 387344001191 substrate binding pocket [chemical binding]; other site 387344001192 flexible flap; other site 387344001193 NAD-dependent deacetylase; Provisional; Region: PRK00481 387344001194 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 387344001195 NAD+ binding site [chemical binding]; other site 387344001196 substrate binding site [chemical binding]; other site 387344001197 putative Zn binding site [ion binding]; other site 387344001198 Protein of unknown function DUF72; Region: DUF72; pfam01904 387344001199 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 387344001200 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 387344001201 active site 387344001202 HIGH motif; other site 387344001203 KMSKS motif; other site 387344001204 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 387344001205 tRNA binding surface [nucleotide binding]; other site 387344001206 anticodon binding site; other site 387344001207 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 387344001208 dimer interface [polypeptide binding]; other site 387344001209 putative tRNA-binding site [nucleotide binding]; other site 387344001210 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 387344001211 active site 387344001212 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 387344001213 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 387344001214 putative active site [active] 387344001215 putative metal binding site [ion binding]; other site 387344001216 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 387344001217 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 387344001218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 387344001219 S-adenosylmethionine binding site [chemical binding]; other site 387344001220 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 387344001221 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 387344001222 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 387344001223 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 387344001224 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 387344001225 putative uracil binding site [chemical binding]; other site 387344001226 putative active site [active] 387344001227 putative alpha-glucosidase; Provisional; Region: PRK10658 387344001228 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 387344001229 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 387344001230 active site 387344001231 homotrimer interface [polypeptide binding]; other site 387344001232 catalytic site [active] 387344001233 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 387344001234 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 387344001235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344001236 MarR family; Region: MarR_2; pfam12802 387344001237 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 387344001238 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 387344001239 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 387344001240 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 387344001241 beta-galactosidase; Region: BGL; TIGR03356 387344001242 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 387344001243 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 387344001244 nucleotide binding site [chemical binding]; other site 387344001245 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 387344001246 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 387344001247 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 387344001248 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 387344001249 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 387344001250 intersubunit interface [polypeptide binding]; other site 387344001251 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 387344001252 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 387344001253 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 387344001254 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 387344001255 putative PBP binding regions; other site 387344001256 ABC-ATPase subunit interface; other site 387344001257 pur operon repressor; Provisional; Region: PRK09213 387344001258 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 387344001259 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 387344001260 active site 387344001261 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 387344001262 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 387344001263 Substrate binding site; other site 387344001264 Mg++ binding site; other site 387344001265 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 387344001266 active site 387344001267 substrate binding site [chemical binding]; other site 387344001268 CoA binding site [chemical binding]; other site 387344001269 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 387344001270 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 387344001271 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 387344001272 active site 387344001273 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 387344001274 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 387344001275 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 387344001276 DNA binding residues [nucleotide binding] 387344001277 dimer interface [polypeptide binding]; other site 387344001278 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 387344001279 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 387344001280 DNA-binding site [nucleotide binding]; DNA binding site 387344001281 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 387344001282 putative phosphoketolase; Provisional; Region: PRK05261 387344001283 XFP N-terminal domain; Region: XFP_N; pfam09364 387344001284 XFP C-terminal domain; Region: XFP_C; pfam09363 387344001285 sugar phosphate phosphatase; Provisional; Region: PRK10513 387344001286 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 387344001287 active site 387344001288 motif I; other site 387344001289 motif II; other site 387344001290 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 387344001291 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 387344001292 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 387344001293 Zn2+ binding site [ion binding]; other site 387344001294 Mg2+ binding site [ion binding]; other site 387344001295 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 387344001296 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 387344001297 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 387344001298 CTP synthetase; Validated; Region: pyrG; PRK05380 387344001299 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 387344001300 Catalytic site [active] 387344001301 active site 387344001302 UTP binding site [chemical binding]; other site 387344001303 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 387344001304 active site 387344001305 putative oxyanion hole; other site 387344001306 catalytic triad [active] 387344001307 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 387344001308 MarR family; Region: MarR_2; pfam12802 387344001309 acetolactate synthase; Reviewed; Region: PRK08617 387344001310 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 387344001311 PYR/PP interface [polypeptide binding]; other site 387344001312 dimer interface [polypeptide binding]; other site 387344001313 TPP binding site [chemical binding]; other site 387344001314 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 387344001315 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 387344001316 TPP-binding site [chemical binding]; other site 387344001317 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 387344001318 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 387344001319 MucBP domain; Region: MucBP; pfam06458 387344001320 MucBP domain; Region: MucBP; pfam06458 387344001321 MucBP domain; Region: MucBP; pfam06458 387344001322 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 387344001323 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 387344001324 hinge; other site 387344001325 active site 387344001326 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 387344001327 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 387344001328 active site 387344001329 catalytic site [active] 387344001330 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 387344001331 Low molecular weight phosphatase family; Region: LMWPc; cd00115 387344001332 active site 387344001333 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 387344001334 heat shock protein HtpX; Provisional; Region: PRK04897 387344001335 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 387344001336 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 387344001337 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 387344001338 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 387344001339 helicase 45; Provisional; Region: PTZ00424 387344001340 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 387344001341 ATP binding site [chemical binding]; other site 387344001342 Mg++ binding site [ion binding]; other site 387344001343 motif III; other site 387344001344 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 387344001345 nucleotide binding region [chemical binding]; other site 387344001346 ATP-binding site [chemical binding]; other site 387344001347 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 387344001348 alanine racemase; Reviewed; Region: alr; PRK00053 387344001349 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 387344001350 active site 387344001351 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 387344001352 dimer interface [polypeptide binding]; other site 387344001353 substrate binding site [chemical binding]; other site 387344001354 catalytic residues [active] 387344001355 PemK-like protein; Region: PemK; pfam02452 387344001356 FOG: CBS domain [General function prediction only]; Region: COG0517 387344001357 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 387344001358 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 387344001359 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 387344001360 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 387344001361 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 387344001362 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 387344001363 tetramer (dimer of dimers) interface [polypeptide binding]; other site 387344001364 NAD binding site [chemical binding]; other site 387344001365 dimer interface [polypeptide binding]; other site 387344001366 substrate binding site [chemical binding]; other site 387344001367 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 387344001368 putative active site [active] 387344001369 catalytic residue [active] 387344001370 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 387344001371 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 387344001372 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 387344001373 ATP binding site [chemical binding]; other site 387344001374 putative Mg++ binding site [ion binding]; other site 387344001375 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 387344001376 nucleotide binding region [chemical binding]; other site 387344001377 ATP-binding site [chemical binding]; other site 387344001378 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 387344001379 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 387344001380 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 387344001381 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 387344001382 RNA binding surface [nucleotide binding]; other site 387344001383 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 387344001384 Septum formation initiator; Region: DivIC; pfam04977 387344001385 hypothetical protein; Provisional; Region: PRK08582 387344001386 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 387344001387 RNA binding site [nucleotide binding]; other site 387344001388 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 387344001389 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 387344001390 Ligand Binding Site [chemical binding]; other site 387344001391 TilS substrate C-terminal domain; Region: TilS_C; smart00977 387344001392 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 387344001393 active site 387344001394 FtsH Extracellular; Region: FtsH_ext; pfam06480 387344001395 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 387344001396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 387344001397 Walker A motif; other site 387344001398 ATP binding site [chemical binding]; other site 387344001399 Walker B motif; other site 387344001400 arginine finger; other site 387344001401 Peptidase family M41; Region: Peptidase_M41; pfam01434 387344001402 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 387344001403 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 387344001404 dimerization interface [polypeptide binding]; other site 387344001405 domain crossover interface; other site 387344001406 redox-dependent activation switch; other site 387344001407 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 387344001408 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 387344001409 FMN binding site [chemical binding]; other site 387344001410 active site 387344001411 catalytic residues [active] 387344001412 substrate binding site [chemical binding]; other site 387344001413 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 387344001414 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 387344001415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344001416 putative substrate translocation pore; other site 387344001417 POT family; Region: PTR2; pfam00854 387344001418 putative phosphoesterase; Region: acc_ester; TIGR03729 387344001419 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 387344001420 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 387344001421 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 387344001422 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 387344001423 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 387344001424 active site 387344001425 dimer interface [polypeptide binding]; other site 387344001426 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 387344001427 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 387344001428 DNA-binding site [nucleotide binding]; DNA binding site 387344001429 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 387344001430 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 387344001431 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 387344001432 Coenzyme A binding pocket [chemical binding]; other site 387344001433 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 387344001434 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 387344001435 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 387344001436 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 387344001437 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 387344001438 active site 387344001439 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 387344001440 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 387344001441 homodimer interface [polypeptide binding]; other site 387344001442 NAD binding pocket [chemical binding]; other site 387344001443 ATP binding pocket [chemical binding]; other site 387344001444 Mg binding site [ion binding]; other site 387344001445 active-site loop [active] 387344001446 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 387344001447 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 387344001448 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 387344001449 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 387344001450 RNA binding site [nucleotide binding]; other site 387344001451 hypothetical protein; Provisional; Region: PRK04351 387344001452 SprT homologues; Region: SprT; cl01182 387344001453 homoserine kinase; Provisional; Region: PRK01212 387344001454 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 387344001455 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 387344001456 Amidohydrolase; Region: Amidohydro_2; pfam04909 387344001457 Predicted membrane protein [Function unknown]; Region: COG2364 387344001458 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 387344001459 MarR family; Region: MarR_2; pfam12802 387344001460 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 387344001461 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 387344001462 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 387344001463 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 387344001464 active site 387344001465 motif I; other site 387344001466 motif II; other site 387344001467 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 387344001468 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 387344001469 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 387344001470 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 387344001471 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 387344001472 metal binding site [ion binding]; metal-binding site 387344001473 active site 387344001474 I-site; other site 387344001475 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 387344001476 Helix-turn-helix domain; Region: HTH_38; pfam13936 387344001477 Integrase core domain; Region: rve; pfam00665 387344001478 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 387344001479 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 387344001480 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 387344001481 Predicted membrane protein [Function unknown]; Region: COG1511 387344001482 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 387344001483 Predicted membrane protein [Function unknown]; Region: COG1511 387344001484 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 387344001485 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 387344001486 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 387344001487 metal binding site [ion binding]; metal-binding site 387344001488 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 387344001489 Membrane transport protein; Region: Mem_trans; pfam03547 387344001490 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 387344001491 EamA-like transporter family; Region: EamA; pfam00892 387344001492 EamA-like transporter family; Region: EamA; pfam00892 387344001493 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 387344001494 catalytic core [active] 387344001495 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 387344001496 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 387344001497 Beta-lactamase; Region: Beta-lactamase; pfam00144 387344001498 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 387344001499 trimer interface [polypeptide binding]; other site 387344001500 active site 387344001501 G bulge; other site 387344001502 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 387344001503 tetramer (dimer of dimers) interface [polypeptide binding]; other site 387344001504 active site 387344001505 dimer interface [polypeptide binding]; other site 387344001506 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 387344001507 trimer interface [polypeptide binding]; other site 387344001508 active site 387344001509 DNA repair protein RadA; Provisional; Region: PRK11823 387344001510 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 387344001511 Walker A motif/ATP binding site; other site 387344001512 ATP binding site [chemical binding]; other site 387344001513 Walker B motif; other site 387344001514 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 387344001515 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 387344001516 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 387344001517 putative active site [active] 387344001518 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 387344001519 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 387344001520 active site 387344001521 HIGH motif; other site 387344001522 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 387344001523 active site 387344001524 KMSKS motif; other site 387344001525 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 387344001526 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 387344001527 active site 387344001528 HIGH motif; other site 387344001529 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 387344001530 KMSKS motif; other site 387344001531 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 387344001532 tRNA binding surface [nucleotide binding]; other site 387344001533 anticodon binding site; other site 387344001534 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 387344001535 active site 387344001536 metal binding site [ion binding]; metal-binding site 387344001537 dimerization interface [polypeptide binding]; other site 387344001538 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 387344001539 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 387344001540 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 387344001541 RNA polymerase factor sigma-70; Validated; Region: PRK08295 387344001542 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 387344001543 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 387344001544 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 387344001545 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 387344001546 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 387344001547 putative homodimer interface [polypeptide binding]; other site 387344001548 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 387344001549 heterodimer interface [polypeptide binding]; other site 387344001550 homodimer interface [polypeptide binding]; other site 387344001551 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 387344001552 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 387344001553 23S rRNA interface [nucleotide binding]; other site 387344001554 L7/L12 interface [polypeptide binding]; other site 387344001555 putative thiostrepton binding site; other site 387344001556 L25 interface [polypeptide binding]; other site 387344001557 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 387344001558 mRNA/rRNA interface [nucleotide binding]; other site 387344001559 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 387344001560 23S rRNA interface [nucleotide binding]; other site 387344001561 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 387344001562 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 387344001563 peripheral dimer interface [polypeptide binding]; other site 387344001564 core dimer interface [polypeptide binding]; other site 387344001565 L10 interface [polypeptide binding]; other site 387344001566 L11 interface [polypeptide binding]; other site 387344001567 putative EF-Tu interaction site [polypeptide binding]; other site 387344001568 putative EF-G interaction site [polypeptide binding]; other site 387344001569 Predicted integral membrane protein [Function unknown]; Region: COG0392 387344001570 Uncharacterized conserved protein [Function unknown]; Region: COG2898 387344001571 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 387344001572 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 387344001573 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 387344001574 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 387344001575 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 387344001576 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 387344001577 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 387344001578 dimer interface [polypeptide binding]; other site 387344001579 putative radical transfer pathway; other site 387344001580 diiron center [ion binding]; other site 387344001581 tyrosyl radical; other site 387344001582 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 387344001583 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 387344001584 Class I ribonucleotide reductase; Region: RNR_I; cd01679 387344001585 active site 387344001586 dimer interface [polypeptide binding]; other site 387344001587 catalytic residues [active] 387344001588 effector binding site; other site 387344001589 R2 peptide binding site; other site 387344001590 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 387344001591 catalytic residues [active] 387344001592 Methyltransferase domain; Region: Methyltransf_31; pfam13847 387344001593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 387344001594 S-adenosylmethionine binding site [chemical binding]; other site 387344001595 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 387344001596 nucleoside/Zn binding site; other site 387344001597 dimer interface [polypeptide binding]; other site 387344001598 catalytic motif [active] 387344001599 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 387344001600 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 387344001601 Walker A motif; other site 387344001602 ATP binding site [chemical binding]; other site 387344001603 Walker B motif; other site 387344001604 arginine finger; other site 387344001605 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 387344001606 hypothetical protein; Validated; Region: PRK00153 387344001607 recombination protein RecR; Reviewed; Region: recR; PRK00076 387344001608 RecR protein; Region: RecR; pfam02132 387344001609 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 387344001610 putative active site [active] 387344001611 putative metal-binding site [ion binding]; other site 387344001612 tetramer interface [polypeptide binding]; other site 387344001613 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 387344001614 thymidylate kinase; Validated; Region: tmk; PRK00698 387344001615 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 387344001616 TMP-binding site; other site 387344001617 ATP-binding site [chemical binding]; other site 387344001618 Protein of unknown function (DUF970); Region: DUF970; pfam06153 387344001619 DNA polymerase III subunit delta'; Validated; Region: PRK08058 387344001620 DNA polymerase III subunit delta'; Validated; Region: PRK08485 387344001621 Protein of unknown function (DUF972); Region: DUF972; pfam06156 387344001622 Predicted methyltransferases [General function prediction only]; Region: COG0313 387344001623 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 387344001624 putative SAM binding site [chemical binding]; other site 387344001625 putative homodimer interface [polypeptide binding]; other site 387344001626 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 387344001627 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 387344001628 active site 387344001629 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 387344001630 active site 2 [active] 387344001631 active site 1 [active] 387344001632 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 387344001633 Glycoprotease family; Region: Peptidase_M22; pfam00814 387344001634 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 387344001635 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 387344001636 Coenzyme A binding pocket [chemical binding]; other site 387344001637 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 387344001638 UGMP family protein; Validated; Region: PRK09604 387344001639 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 387344001640 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 387344001641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344001642 putative substrate translocation pore; other site 387344001643 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 387344001644 dimerization interface [polypeptide binding]; other site 387344001645 putative DNA binding site [nucleotide binding]; other site 387344001646 putative Zn2+ binding site [ion binding]; other site 387344001647 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 387344001648 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 387344001649 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 387344001650 ABC transporter; Region: ABC_tran_2; pfam12848 387344001651 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 387344001652 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 387344001653 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 387344001654 CoA binding domain; Region: CoA_binding; pfam02629 387344001655 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 387344001656 oligomerisation interface [polypeptide binding]; other site 387344001657 mobile loop; other site 387344001658 roof hairpin; other site 387344001659 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 387344001660 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 387344001661 ring oligomerisation interface [polypeptide binding]; other site 387344001662 ATP/Mg binding site [chemical binding]; other site 387344001663 stacking interactions; other site 387344001664 hinge regions; other site 387344001665 Amino acid permease; Region: AA_permease_2; pfam13520 387344001666 LrgB-like family; Region: LrgB; cl00596 387344001667 LrgA family; Region: LrgA; cl00608 387344001668 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 387344001669 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 387344001670 Mg++ binding site [ion binding]; other site 387344001671 putative catalytic motif [active] 387344001672 substrate binding site [chemical binding]; other site 387344001673 Uncharacterized conserved protein [Function unknown]; Region: COG1739 387344001674 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 387344001675 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 387344001676 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 387344001677 ATP binding site [chemical binding]; other site 387344001678 putative Mg++ binding site [ion binding]; other site 387344001679 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 387344001680 nucleotide binding region [chemical binding]; other site 387344001681 ATP-binding site [chemical binding]; other site 387344001682 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 387344001683 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 387344001684 active site 387344001685 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 387344001686 30S subunit binding site; other site 387344001687 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 387344001688 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 387344001689 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 387344001690 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 387344001691 nucleotide binding region [chemical binding]; other site 387344001692 ATP-binding site [chemical binding]; other site 387344001693 peptide chain release factor 2; Validated; Region: prfB; PRK00578 387344001694 This domain is found in peptide chain release factors; Region: PCRF; smart00937 387344001695 RF-1 domain; Region: RF-1; pfam00472 387344001696 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 387344001697 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 387344001698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 387344001699 active site 387344001700 phosphorylation site [posttranslational modification] 387344001701 intermolecular recognition site; other site 387344001702 dimerization interface [polypeptide binding]; other site 387344001703 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 387344001704 DNA binding site [nucleotide binding] 387344001705 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 387344001706 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 387344001707 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 387344001708 dimer interface [polypeptide binding]; other site 387344001709 phosphorylation site [posttranslational modification] 387344001710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 387344001711 ATP binding site [chemical binding]; other site 387344001712 Mg2+ binding site [ion binding]; other site 387344001713 G-X-G motif; other site 387344001714 PBP superfamily domain; Region: PBP_like_2; cl17296 387344001715 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 387344001716 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 387344001717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 387344001718 dimer interface [polypeptide binding]; other site 387344001719 conserved gate region; other site 387344001720 putative PBP binding loops; other site 387344001721 ABC-ATPase subunit interface; other site 387344001722 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 387344001723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 387344001724 dimer interface [polypeptide binding]; other site 387344001725 conserved gate region; other site 387344001726 putative PBP binding loops; other site 387344001727 ABC-ATPase subunit interface; other site 387344001728 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 387344001729 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 387344001730 Walker A/P-loop; other site 387344001731 ATP binding site [chemical binding]; other site 387344001732 Q-loop/lid; other site 387344001733 ABC transporter signature motif; other site 387344001734 Walker B; other site 387344001735 D-loop; other site 387344001736 H-loop/switch region; other site 387344001737 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 387344001738 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 387344001739 Walker A/P-loop; other site 387344001740 ATP binding site [chemical binding]; other site 387344001741 Q-loop/lid; other site 387344001742 ABC transporter signature motif; other site 387344001743 Walker B; other site 387344001744 D-loop; other site 387344001745 H-loop/switch region; other site 387344001746 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 387344001747 PhoU domain; Region: PhoU; pfam01895 387344001748 PhoU domain; Region: PhoU; pfam01895 387344001749 PspC domain; Region: PspC; pfam04024 387344001750 Membrane protein of unknown function; Region: DUF360; cl00850 387344001751 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 387344001752 HPr kinase/phosphorylase; Provisional; Region: PRK05428 387344001753 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 387344001754 Hpr binding site; other site 387344001755 active site 387344001756 homohexamer subunit interaction site [polypeptide binding]; other site 387344001757 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 387344001758 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 387344001759 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 387344001760 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 387344001761 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 387344001762 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 387344001763 active site 387344001764 tetramer interface; other site 387344001765 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 387344001766 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 387344001767 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 387344001768 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 387344001769 Zn2+ binding site [ion binding]; other site 387344001770 Mg2+ binding site [ion binding]; other site 387344001771 excinuclease ABC subunit B; Provisional; Region: PRK05298 387344001772 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 387344001773 ATP binding site [chemical binding]; other site 387344001774 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 387344001775 nucleotide binding region [chemical binding]; other site 387344001776 ATP-binding site [chemical binding]; other site 387344001777 Ultra-violet resistance protein B; Region: UvrB; pfam12344 387344001778 UvrB/uvrC motif; Region: UVR; pfam02151 387344001779 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 387344001780 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 387344001781 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 387344001782 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 387344001783 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 387344001784 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 387344001785 shikimate kinase; Reviewed; Region: aroK; PRK00131 387344001786 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 387344001787 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 387344001788 phosphate binding site [ion binding]; other site 387344001789 putative substrate binding pocket [chemical binding]; other site 387344001790 dimer interface [polypeptide binding]; other site 387344001791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 387344001792 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 387344001793 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 387344001794 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 387344001795 oligomer interface [polypeptide binding]; other site 387344001796 active site residues [active] 387344001797 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 387344001798 LytTr DNA-binding domain; Region: LytTR; smart00850 387344001799 Predicted membrane protein [Function unknown]; Region: COG4684 387344001800 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 387344001801 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 387344001802 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 387344001803 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 387344001804 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 387344001805 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 387344001806 Phosphoglycerate kinase; Region: PGK; pfam00162 387344001807 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 387344001808 substrate binding site [chemical binding]; other site 387344001809 hinge regions; other site 387344001810 ADP binding site [chemical binding]; other site 387344001811 catalytic site [active] 387344001812 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 387344001813 triosephosphate isomerase; Provisional; Region: PRK14567 387344001814 substrate binding site [chemical binding]; other site 387344001815 dimer interface [polypeptide binding]; other site 387344001816 catalytic triad [active] 387344001817 enolase; Provisional; Region: eno; PRK00077 387344001818 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 387344001819 dimer interface [polypeptide binding]; other site 387344001820 metal binding site [ion binding]; metal-binding site 387344001821 substrate binding pocket [chemical binding]; other site 387344001822 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 387344001823 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 387344001824 Cl- selectivity filter; other site 387344001825 Cl- binding residues [ion binding]; other site 387344001826 pore gating glutamate residue; other site 387344001827 dimer interface [polypeptide binding]; other site 387344001828 H+/Cl- coupling transport residue; other site 387344001829 TrkA-C domain; Region: TrkA_C; pfam02080 387344001830 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 387344001831 Esterase/lipase [General function prediction only]; Region: COG1647 387344001832 ribonuclease R; Region: RNase_R; TIGR02063 387344001833 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 387344001834 RNB domain; Region: RNB; pfam00773 387344001835 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 387344001836 RNA binding site [nucleotide binding]; other site 387344001837 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 387344001838 SmpB-tmRNA interface; other site 387344001839 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 387344001840 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 387344001841 Walker A/P-loop; other site 387344001842 ATP binding site [chemical binding]; other site 387344001843 Q-loop/lid; other site 387344001844 ABC transporter signature motif; other site 387344001845 Walker B; other site 387344001846 D-loop; other site 387344001847 H-loop/switch region; other site 387344001848 Tubby C 2; Region: Tub_2; cl02043 387344001849 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 387344001850 ligand binding site [chemical binding]; other site 387344001851 active site 387344001852 UGI interface [polypeptide binding]; other site 387344001853 catalytic site [active] 387344001854 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 387344001855 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 387344001856 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 387344001857 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 387344001858 Coenzyme A binding pocket [chemical binding]; other site 387344001859 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 387344001860 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 387344001861 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 387344001862 active site 387344001863 catalytic tetrad [active] 387344001864 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 387344001865 active site 387344001866 catalytic site [active] 387344001867 substrate binding site [chemical binding]; other site 387344001868 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 387344001869 active site 387344001870 putative catalytic site [active] 387344001871 DNA binding site [nucleotide binding] 387344001872 putative phosphate binding site [ion binding]; other site 387344001873 metal binding site A [ion binding]; metal-binding site 387344001874 AP binding site [nucleotide binding]; other site 387344001875 metal binding site B [ion binding]; metal-binding site 387344001876 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 387344001877 FAD binding domain; Region: FAD_binding_4; pfam01565 387344001878 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 387344001879 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 387344001880 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 387344001881 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 387344001882 Uncharacterized conserved protein [Function unknown]; Region: COG1624 387344001883 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 387344001884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 387344001885 YbbR-like protein; Region: YbbR; pfam07949 387344001886 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 387344001887 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 387344001888 active site 387344001889 substrate binding site [chemical binding]; other site 387344001890 metal binding site [ion binding]; metal-binding site 387344001891 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 387344001892 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 387344001893 glutaminase active site [active] 387344001894 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 387344001895 dimer interface [polypeptide binding]; other site 387344001896 active site 387344001897 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 387344001898 dimer interface [polypeptide binding]; other site 387344001899 active site 387344001900 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 387344001901 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 387344001902 active site 387344001903 trimer interface [polypeptide binding]; other site 387344001904 allosteric site; other site 387344001905 active site lid [active] 387344001906 hexamer (dimer of trimers) interface [polypeptide binding]; other site 387344001907 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 387344001908 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 387344001909 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 387344001910 Soluble P-type ATPase [General function prediction only]; Region: COG4087 387344001911 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 387344001912 Ferritin-like domain; Region: Ferritin; pfam00210 387344001913 dimerization interface [polypeptide binding]; other site 387344001914 DPS ferroxidase diiron center [ion binding]; other site 387344001915 ion pore; other site 387344001916 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 387344001917 metal-binding site [ion binding] 387344001918 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 387344001919 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 387344001920 Walker A/P-loop; other site 387344001921 ATP binding site [chemical binding]; other site 387344001922 Q-loop/lid; other site 387344001923 ABC transporter signature motif; other site 387344001924 Walker B; other site 387344001925 D-loop; other site 387344001926 H-loop/switch region; other site 387344001927 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 387344001928 heme-binding site [chemical binding]; other site 387344001929 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 387344001930 heme-binding site [chemical binding]; other site 387344001931 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 387344001932 heme-binding site [chemical binding]; other site 387344001933 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 387344001934 heme-binding site [chemical binding]; other site 387344001935 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 387344001936 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 387344001937 intersubunit interface [polypeptide binding]; other site 387344001938 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 387344001939 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 387344001940 ABC-ATPase subunit interface; other site 387344001941 dimer interface [polypeptide binding]; other site 387344001942 putative PBP binding regions; other site 387344001943 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 387344001944 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 387344001945 Walker A/P-loop; other site 387344001946 ATP binding site [chemical binding]; other site 387344001947 Q-loop/lid; other site 387344001948 ABC transporter signature motif; other site 387344001949 Walker B; other site 387344001950 D-loop; other site 387344001951 H-loop/switch region; other site 387344001952 exopolyphosphatase; Region: exo_poly_only; TIGR03706 387344001953 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 387344001954 polyphosphate kinase; Provisional; Region: PRK05443 387344001955 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 387344001956 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 387344001957 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 387344001958 putative domain interface [polypeptide binding]; other site 387344001959 putative active site [active] 387344001960 catalytic site [active] 387344001961 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 387344001962 putative domain interface [polypeptide binding]; other site 387344001963 putative active site [active] 387344001964 catalytic site [active] 387344001965 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 387344001966 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 387344001967 LicD family; Region: LicD; pfam04991 387344001968 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 387344001969 MarR family; Region: MarR_2; pfam12802 387344001970 OsmC-like protein; Region: OsmC; pfam02566 387344001971 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 387344001972 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 387344001973 fumarate hydratase; Reviewed; Region: fumC; PRK00485 387344001974 Class II fumarases; Region: Fumarase_classII; cd01362 387344001975 active site 387344001976 tetramer interface [polypeptide binding]; other site 387344001977 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 387344001978 hypothetical protein; Provisional; Region: PRK06446 387344001979 metal binding site [ion binding]; metal-binding site 387344001980 dimer interface [polypeptide binding]; other site 387344001981 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 387344001982 Helix-turn-helix domain; Region: HTH_38; pfam13936 387344001983 Integrase core domain; Region: rve; pfam00665 387344001984 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 387344001985 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 387344001986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 387344001987 S-adenosylmethionine binding site [chemical binding]; other site 387344001988 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 387344001989 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 387344001990 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 387344001991 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 387344001992 S-adenosylmethionine binding site [chemical binding]; other site 387344001993 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 387344001994 RNA methyltransferase, RsmE family; Region: TIGR00046 387344001995 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 387344001996 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 387344001997 Zn2+ binding site [ion binding]; other site 387344001998 Mg2+ binding site [ion binding]; other site 387344001999 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 387344002000 synthetase active site [active] 387344002001 NTP binding site [chemical binding]; other site 387344002002 metal binding site [ion binding]; metal-binding site 387344002003 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 387344002004 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 387344002005 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 387344002006 putative active site [active] 387344002007 dimerization interface [polypeptide binding]; other site 387344002008 putative tRNAtyr binding site [nucleotide binding]; other site 387344002009 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 387344002010 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 387344002011 motif II; other site 387344002012 Phosphotransferase enzyme family; Region: APH; pfam01636 387344002013 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 387344002014 active site 387344002015 ATP binding site [chemical binding]; other site 387344002016 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 387344002017 substrate binding site [chemical binding]; other site 387344002018 Bacterial SH3 domain; Region: SH3_3; pfam08239 387344002019 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 387344002020 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 387344002021 active site 387344002022 metal binding site [ion binding]; metal-binding site 387344002023 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 387344002024 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 387344002025 dimer interface [polypeptide binding]; other site 387344002026 motif 1; other site 387344002027 active site 387344002028 motif 2; other site 387344002029 motif 3; other site 387344002030 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 387344002031 anticodon binding site; other site 387344002032 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 387344002033 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 387344002034 dimer interface [polypeptide binding]; other site 387344002035 anticodon binding site; other site 387344002036 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 387344002037 homodimer interface [polypeptide binding]; other site 387344002038 motif 1; other site 387344002039 active site 387344002040 motif 2; other site 387344002041 GAD domain; Region: GAD; pfam02938 387344002042 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 387344002043 active site 387344002044 motif 3; other site 387344002045 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 387344002046 Uncharacterized conserved protein [Function unknown]; Region: COG1284 387344002047 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 387344002048 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 387344002049 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 387344002050 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 387344002051 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 387344002052 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 387344002053 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 387344002054 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 387344002055 endonuclease IV; Provisional; Region: PRK01060 387344002056 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 387344002057 AP (apurinic/apyrimidinic) site pocket; other site 387344002058 DNA interaction; other site 387344002059 Metal-binding active site; metal-binding site 387344002060 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 387344002061 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 387344002062 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 387344002063 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 387344002064 putative NAD(P) binding site [chemical binding]; other site 387344002065 dimer interface [polypeptide binding]; other site 387344002066 Predicted transcriptional regulators [Transcription]; Region: COG1733 387344002067 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 387344002068 Yqey-like protein; Region: YqeY; pfam09424 387344002069 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 387344002070 PhoH-like protein; Region: PhoH; pfam02562 387344002071 metal-binding heat shock protein; Provisional; Region: PRK00016 387344002072 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 387344002073 GTPase Era; Reviewed; Region: era; PRK00089 387344002074 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 387344002075 G1 box; other site 387344002076 GTP/Mg2+ binding site [chemical binding]; other site 387344002077 Switch I region; other site 387344002078 G2 box; other site 387344002079 Switch II region; other site 387344002080 G3 box; other site 387344002081 G4 box; other site 387344002082 G5 box; other site 387344002083 KH domain; Region: KH_2; pfam07650 387344002084 DNA repair protein RecO; Region: reco; TIGR00613 387344002085 Recombination protein O N terminal; Region: RecO_N; pfam11967 387344002086 Recombination protein O C terminal; Region: RecO_C; pfam02565 387344002087 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 387344002088 dimer interface [polypeptide binding]; other site 387344002089 motif 1; other site 387344002090 active site 387344002091 motif 2; other site 387344002092 motif 3; other site 387344002093 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 387344002094 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 387344002095 DNA primase; Validated; Region: dnaG; PRK05667 387344002096 CHC2 zinc finger; Region: zf-CHC2; pfam01807 387344002097 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 387344002098 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 387344002099 active site 387344002100 metal binding site [ion binding]; metal-binding site 387344002101 interdomain interaction site; other site 387344002102 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 387344002103 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 387344002104 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 387344002105 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 387344002106 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 387344002107 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 387344002108 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 387344002109 Predicted transcriptional regulator [Transcription]; Region: COG1959 387344002110 Transcriptional regulator; Region: Rrf2; pfam02082 387344002111 MMPL family; Region: MMPL; pfam03176 387344002112 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 387344002113 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 387344002114 Family of unknown function (DUF633); Region: DUF633; pfam04816 387344002115 Uncharacterized conserved protein [Function unknown]; Region: COG0327 387344002116 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 387344002117 peptidase T; Region: peptidase-T; TIGR01882 387344002118 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 387344002119 metal binding site [ion binding]; metal-binding site 387344002120 dimer interface [polypeptide binding]; other site 387344002121 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 387344002122 Clp amino terminal domain; Region: Clp_N; pfam02861 387344002123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 387344002124 Walker A motif; other site 387344002125 ATP binding site [chemical binding]; other site 387344002126 Walker B motif; other site 387344002127 arginine finger; other site 387344002128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 387344002129 Walker A motif; other site 387344002130 ATP binding site [chemical binding]; other site 387344002131 Walker B motif; other site 387344002132 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 387344002133 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 387344002134 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 387344002135 active site 387344002136 PHP Thumb interface [polypeptide binding]; other site 387344002137 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 387344002138 generic binding surface II; other site 387344002139 generic binding surface I; other site 387344002140 putative translaldolase; Provisional; Region: PRK12376 387344002141 catalytic residue [active] 387344002142 pyruvate kinase; Provisional; Region: PRK06354 387344002143 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 387344002144 domain interfaces; other site 387344002145 active site 387344002146 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 387344002147 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 387344002148 S1 domain; Region: S1_2; pfam13509 387344002149 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 387344002150 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 387344002151 active site 387344002152 Int/Topo IB signature motif; other site 387344002153 ScpA/B protein; Region: ScpA_ScpB; cl00598 387344002154 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 387344002155 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 387344002156 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 387344002157 RNA binding surface [nucleotide binding]; other site 387344002158 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 387344002159 active site 387344002160 Predicted membrane protein [Function unknown]; Region: COG3601 387344002161 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 387344002162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 387344002163 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 387344002164 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 387344002165 ATP binding site [chemical binding]; other site 387344002166 putative Mg++ binding site [ion binding]; other site 387344002167 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 387344002168 nucleotide binding region [chemical binding]; other site 387344002169 ATP-binding site [chemical binding]; other site 387344002170 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 387344002171 cytidylate kinase; Provisional; Region: cmk; PRK00023 387344002172 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 387344002173 CMP-binding site; other site 387344002174 The sites determining sugar specificity; other site 387344002175 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 387344002176 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 387344002177 RNA binding site [nucleotide binding]; other site 387344002178 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 387344002179 RNA binding site [nucleotide binding]; other site 387344002180 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 387344002181 RNA binding site [nucleotide binding]; other site 387344002182 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 387344002183 RNA binding site [nucleotide binding]; other site 387344002184 GTP-binding protein Der; Reviewed; Region: PRK00093 387344002185 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 387344002186 G1 box; other site 387344002187 GTP/Mg2+ binding site [chemical binding]; other site 387344002188 Switch I region; other site 387344002189 G2 box; other site 387344002190 Switch II region; other site 387344002191 G3 box; other site 387344002192 G4 box; other site 387344002193 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 387344002194 G1 box; other site 387344002195 GTP/Mg2+ binding site [chemical binding]; other site 387344002196 Switch I region; other site 387344002197 G2 box; other site 387344002198 G3 box; other site 387344002199 Switch II region; other site 387344002200 G4 box; other site 387344002201 G5 box; other site 387344002202 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 387344002203 IHF dimer interface [polypeptide binding]; other site 387344002204 IHF - DNA interface [nucleotide binding]; other site 387344002205 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 387344002206 binding surface 387344002207 TPR motif; other site 387344002208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 387344002209 binding surface 387344002210 TPR motif; other site 387344002211 Uncharacterized conserved protein [Function unknown]; Region: COG1284 387344002212 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 387344002213 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 387344002214 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 387344002215 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 387344002216 active site 387344002217 NTP binding site [chemical binding]; other site 387344002218 metal binding triad [ion binding]; metal-binding site 387344002219 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 387344002220 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 387344002221 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 387344002222 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 387344002223 Walker A/P-loop; other site 387344002224 ATP binding site [chemical binding]; other site 387344002225 Q-loop/lid; other site 387344002226 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 387344002227 ABC transporter signature motif; other site 387344002228 Walker B; other site 387344002229 D-loop; other site 387344002230 ABC transporter; Region: ABC_tran_2; pfam12848 387344002231 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 387344002232 thymidylate synthase; Region: thym_sym; TIGR03284 387344002233 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 387344002234 dimerization interface [polypeptide binding]; other site 387344002235 active site 387344002236 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 387344002237 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 387344002238 folate binding site [chemical binding]; other site 387344002239 NADP+ binding site [chemical binding]; other site 387344002240 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 387344002241 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 387344002242 EDD domain protein, DegV family; Region: DegV; TIGR00762 387344002243 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 387344002244 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 387344002245 active site 387344002246 catalytic triad [active] 387344002247 oxyanion hole [active] 387344002248 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 387344002249 hypothetical protein; Provisional; Region: PRK13672 387344002250 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 387344002251 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 387344002252 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 387344002253 GTP/Mg2+ binding site [chemical binding]; other site 387344002254 G4 box; other site 387344002255 G5 box; other site 387344002256 G1 box; other site 387344002257 Switch I region; other site 387344002258 G2 box; other site 387344002259 G3 box; other site 387344002260 Switch II region; other site 387344002261 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 387344002262 RNA/DNA hybrid binding site [nucleotide binding]; other site 387344002263 active site 387344002264 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 387344002265 DNA protecting protein DprA; Region: dprA; TIGR00732 387344002266 DNA topoisomerase I; Validated; Region: PRK05582 387344002267 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 387344002268 active site 387344002269 interdomain interaction site; other site 387344002270 putative metal-binding site [ion binding]; other site 387344002271 nucleotide binding site [chemical binding]; other site 387344002272 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 387344002273 domain I; other site 387344002274 DNA binding groove [nucleotide binding] 387344002275 phosphate binding site [ion binding]; other site 387344002276 domain II; other site 387344002277 domain III; other site 387344002278 nucleotide binding site [chemical binding]; other site 387344002279 catalytic site [active] 387344002280 domain IV; other site 387344002281 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 387344002282 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 387344002283 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 387344002284 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 387344002285 active site 387344002286 DNA binding site [nucleotide binding] 387344002287 Int/Topo IB signature motif; other site 387344002288 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 387344002289 active site 387344002290 HslU subunit interaction site [polypeptide binding]; other site 387344002291 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 387344002292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 387344002293 Walker A motif; other site 387344002294 ATP binding site [chemical binding]; other site 387344002295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 387344002296 Walker B motif; other site 387344002297 arginine finger; other site 387344002298 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 387344002299 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 387344002300 active site 387344002301 catalytic residues [active] 387344002302 membrane protein; Provisional; Region: PRK14392 387344002303 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 387344002304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 387344002305 ATP binding site [chemical binding]; other site 387344002306 Mg2+ binding site [ion binding]; other site 387344002307 G-X-G motif; other site 387344002308 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 387344002309 anchoring element; other site 387344002310 dimer interface [polypeptide binding]; other site 387344002311 ATP binding site [chemical binding]; other site 387344002312 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 387344002313 active site 387344002314 putative metal-binding site [ion binding]; other site 387344002315 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 387344002316 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 387344002317 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 387344002318 CAP-like domain; other site 387344002319 active site 387344002320 primary dimer interface [polypeptide binding]; other site 387344002321 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 387344002322 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 387344002323 Transcriptional regulator [Transcription]; Region: LysR; COG0583 387344002324 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 387344002325 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 387344002326 dimerization interface [polypeptide binding]; other site 387344002327 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 387344002328 DHH family; Region: DHH; pfam01368 387344002329 DHHA2 domain; Region: DHHA2; pfam02833 387344002330 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 387344002331 active site 387344002332 methionine sulfoxide reductase B; Provisional; Region: PRK00222 387344002333 SelR domain; Region: SelR; pfam01641 387344002334 methionine sulfoxide reductase A; Provisional; Region: PRK14054 387344002335 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 387344002336 nudix motif; other site 387344002337 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 387344002338 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 387344002339 active site 387344002340 DNA binding site [nucleotide binding] 387344002341 Int/Topo IB signature motif; other site 387344002342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 387344002343 S-adenosylmethionine binding site [chemical binding]; other site 387344002344 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 387344002345 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 387344002346 active site 387344002347 metal binding site [ion binding]; metal-binding site 387344002348 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 387344002349 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 387344002350 putative NAD(P) binding site [chemical binding]; other site 387344002351 Helix-Turn-Helix DNA binding domain of BmrR-like transcription regulators; Region: HTH_BmrR-like; cd04768 387344002352 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 387344002353 DNA binding residues [nucleotide binding] 387344002354 drug binding residues [chemical binding]; other site 387344002355 dimer interface [polypeptide binding]; other site 387344002356 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 387344002357 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 387344002358 minor groove reading motif; other site 387344002359 helix-hairpin-helix signature motif; other site 387344002360 substrate binding pocket [chemical binding]; other site 387344002361 active site 387344002362 VanZ like family; Region: VanZ; cl01971 387344002363 Predicted membrane protein [Function unknown]; Region: COG2246 387344002364 GtrA-like protein; Region: GtrA; pfam04138 387344002365 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 387344002366 EDD domain protein, DegV family; Region: DegV; TIGR00762 387344002367 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 387344002368 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 387344002369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344002370 putative substrate translocation pore; other site 387344002371 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 387344002372 Transcriptional regulators [Transcription]; Region: MarR; COG1846 387344002373 MarR family; Region: MarR_2; pfam12802 387344002374 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 387344002375 Domain of unknown function (DUF814); Region: DUF814; pfam05670 387344002376 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 387344002377 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 387344002378 ATP-grasp domain; Region: ATP-grasp_4; cl17255 387344002379 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 387344002380 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 387344002381 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 387344002382 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 387344002383 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 387344002384 catalytic site [active] 387344002385 subunit interface [polypeptide binding]; other site 387344002386 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 387344002387 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 387344002388 active site 387344002389 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 387344002390 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 387344002391 RNA binding surface [nucleotide binding]; other site 387344002392 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 387344002393 active site 387344002394 lipoprotein signal peptidase; Provisional; Region: PRK14797 387344002395 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 387344002396 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 387344002397 Potassium binding sites [ion binding]; other site 387344002398 Cesium cation binding sites [ion binding]; other site 387344002399 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 387344002400 RNA/DNA hybrid binding site [nucleotide binding]; other site 387344002401 active site 387344002402 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 387344002403 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 387344002404 dimer interface [polypeptide binding]; other site 387344002405 FMN binding site [chemical binding]; other site 387344002406 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 387344002407 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 387344002408 CAAX protease self-immunity; Region: Abi; pfam02517 387344002409 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 387344002410 nudix motif; other site 387344002411 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 387344002412 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 387344002413 nucleotide binding site/active site [active] 387344002414 HIT family signature motif; other site 387344002415 catalytic residue [active] 387344002416 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 387344002417 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 387344002418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 387344002419 cell division protein GpsB; Provisional; Region: PRK14127 387344002420 DivIVA domain; Region: DivI1A_domain; TIGR03544 387344002421 hypothetical protein; Provisional; Region: PRK13660 387344002422 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 387344002423 Transglycosylase; Region: Transgly; pfam00912 387344002424 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 387344002425 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 387344002426 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 387344002427 active site residue [active] 387344002428 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 387344002429 MarR family; Region: MarR_2; cl17246 387344002430 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 387344002431 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 387344002432 aspartate aminotransferase; Provisional; Region: PRK05764 387344002433 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 387344002434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 387344002435 homodimer interface [polypeptide binding]; other site 387344002436 catalytic residue [active] 387344002437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 387344002438 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 387344002439 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 387344002440 active site 387344002441 catalytic site [active] 387344002442 substrate binding site [chemical binding]; other site 387344002443 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 387344002444 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 387344002445 mevalonate kinase; Region: mevalon_kin; TIGR00549 387344002446 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 387344002447 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 387344002448 diphosphomevalonate decarboxylase; Region: PLN02407 387344002449 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 387344002450 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 387344002451 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 387344002452 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 387344002453 homotetramer interface [polypeptide binding]; other site 387344002454 FMN binding site [chemical binding]; other site 387344002455 homodimer contacts [polypeptide binding]; other site 387344002456 putative active site [active] 387344002457 putative substrate binding site [chemical binding]; other site 387344002458 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 387344002459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 387344002460 S-adenosylmethionine binding site [chemical binding]; other site 387344002461 Uncharacterized conserved protein [Function unknown]; Region: COG3270 387344002462 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 387344002463 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 387344002464 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 387344002465 active site 387344002466 motif I; other site 387344002467 motif II; other site 387344002468 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 387344002469 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 387344002470 metal binding site [ion binding]; metal-binding site 387344002471 dimer interface [polypeptide binding]; other site 387344002472 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 387344002473 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 387344002474 active site 387344002475 catalytic tetrad [active] 387344002476 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 387344002477 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 387344002478 active site 387344002479 catalytic tetrad [active] 387344002480 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 387344002481 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 387344002482 catalytic Zn binding site [ion binding]; other site 387344002483 NAD(P) binding site [chemical binding]; other site 387344002484 structural Zn binding site [ion binding]; other site 387344002485 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078 387344002486 MarR family; Region: MarR_2; pfam12802 387344002487 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 387344002488 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 387344002489 DNA binding residues [nucleotide binding] 387344002490 putative dimer interface [polypeptide binding]; other site 387344002491 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 387344002492 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 387344002493 putative NAD(P) binding site [chemical binding]; other site 387344002494 K+ potassium transporter; Region: K_trans; pfam02705 387344002495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 387344002496 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 387344002497 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 387344002498 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 387344002499 ABC-2 type transporter; Region: ABC2_membrane; cl17235 387344002500 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 387344002501 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 387344002502 Walker A/P-loop; other site 387344002503 ATP binding site [chemical binding]; other site 387344002504 Q-loop/lid; other site 387344002505 ABC transporter signature motif; other site 387344002506 Walker B; other site 387344002507 D-loop; other site 387344002508 H-loop/switch region; other site 387344002509 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 387344002510 active site 387344002511 metal binding site [ion binding]; metal-binding site 387344002512 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 387344002513 Low molecular weight phosphatase family; Region: LMWPc; cd00115 387344002514 active site 387344002515 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 387344002516 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 387344002517 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 387344002518 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 387344002519 Walker A/P-loop; other site 387344002520 ATP binding site [chemical binding]; other site 387344002521 Q-loop/lid; other site 387344002522 ABC transporter signature motif; other site 387344002523 Walker B; other site 387344002524 D-loop; other site 387344002525 H-loop/switch region; other site 387344002526 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 387344002527 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 387344002528 FtsX-like permease family; Region: FtsX; pfam02687 387344002529 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 387344002530 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 387344002531 DXD motif; other site 387344002532 exosortase family protein XrtG; Region: exosort_Gpos; TIGR03110 387344002533 Firmicu-CTERM domain; Region: Firmicu_CTERM; TIGR04145 387344002534 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 387344002535 sequence-specific DNA binding site [nucleotide binding]; other site 387344002536 salt bridge; other site 387344002537 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 387344002538 Helix-turn-helix domain; Region: HTH_38; pfam13936 387344002539 Integrase core domain; Region: rve; pfam00665 387344002540 glycerol kinase; Provisional; Region: glpK; PRK00047 387344002541 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 387344002542 N- and C-terminal domain interface [polypeptide binding]; other site 387344002543 active site 387344002544 MgATP binding site [chemical binding]; other site 387344002545 catalytic site [active] 387344002546 metal binding site [ion binding]; metal-binding site 387344002547 glycerol binding site [chemical binding]; other site 387344002548 homotetramer interface [polypeptide binding]; other site 387344002549 homodimer interface [polypeptide binding]; other site 387344002550 FBP binding site [chemical binding]; other site 387344002551 protein IIAGlc interface [polypeptide binding]; other site 387344002552 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 387344002553 active site 1 [active] 387344002554 dimer interface [polypeptide binding]; other site 387344002555 hexamer interface [polypeptide binding]; other site 387344002556 active site 2 [active] 387344002557 Uncharacterized conserved protein [Function unknown]; Region: COG1284 387344002558 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 387344002559 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 387344002560 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 387344002561 Peptidase family C69; Region: Peptidase_C69; pfam03577 387344002562 inner membrane transporter YjeM; Provisional; Region: PRK15238 387344002563 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 387344002564 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 387344002565 non-specific DNA binding site [nucleotide binding]; other site 387344002566 salt bridge; other site 387344002567 sequence-specific DNA binding site [nucleotide binding]; other site 387344002568 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 387344002569 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 387344002570 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 387344002571 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 387344002572 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 387344002573 tetramer interface [polypeptide binding]; other site 387344002574 heme binding pocket [chemical binding]; other site 387344002575 NADPH binding site [chemical binding]; other site 387344002576 GTPase RsgA; Reviewed; Region: PRK01889 387344002577 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 387344002578 RNA binding site [nucleotide binding]; other site 387344002579 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 387344002580 GTPase/Zn-binding domain interface [polypeptide binding]; other site 387344002581 GTP/Mg2+ binding site [chemical binding]; other site 387344002582 G4 box; other site 387344002583 G5 box; other site 387344002584 G1 box; other site 387344002585 Switch I region; other site 387344002586 G2 box; other site 387344002587 G3 box; other site 387344002588 Switch II region; other site 387344002589 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 387344002590 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 387344002591 active site 387344002592 catalytic tetrad [active] 387344002593 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 387344002594 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 387344002595 DNA binding residues [nucleotide binding] 387344002596 putative dimer interface [polypeptide binding]; other site 387344002597 Transcriptional regulator [Transcription]; Region: LysR; COG0583 387344002598 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 387344002599 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 387344002600 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 387344002601 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 387344002602 catalytic Zn binding site [ion binding]; other site 387344002603 NAD binding site [chemical binding]; other site 387344002604 structural Zn binding site [ion binding]; other site 387344002605 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 387344002606 conserved cys residue [active] 387344002607 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 387344002608 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 387344002609 LytTr DNA-binding domain; Region: LytTR; smart00850 387344002610 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 387344002611 Isochorismatase family; Region: Isochorismatase; pfam00857 387344002612 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 387344002613 catalytic triad [active] 387344002614 conserved cis-peptide bond; other site 387344002615 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 387344002616 metal binding site [ion binding]; metal-binding site 387344002617 BioY family; Region: BioY; pfam02632 387344002618 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 387344002619 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 387344002620 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 387344002621 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 387344002622 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 387344002623 NAD binding site [chemical binding]; other site 387344002624 homotetramer interface [polypeptide binding]; other site 387344002625 homodimer interface [polypeptide binding]; other site 387344002626 substrate binding site [chemical binding]; other site 387344002627 active site 387344002628 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 387344002629 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 387344002630 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 387344002631 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 387344002632 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 387344002633 ATP-grasp domain; Region: ATP-grasp_4; cl17255 387344002634 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 387344002635 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 387344002636 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 387344002637 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 387344002638 carboxyltransferase (CT) interaction site; other site 387344002639 biotinylation site [posttranslational modification]; other site 387344002640 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 387344002641 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 387344002642 dimer interface [polypeptide binding]; other site 387344002643 active site 387344002644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 387344002645 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 387344002646 NAD(P) binding site [chemical binding]; other site 387344002647 active site 387344002648 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 387344002649 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 387344002650 acyl carrier protein; Provisional; Region: acpP; PRK00982 387344002651 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 387344002652 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 387344002653 dimer interface [polypeptide binding]; other site 387344002654 active site 387344002655 CoA binding pocket [chemical binding]; other site 387344002656 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 387344002657 MarR family; Region: MarR_2; pfam12802 387344002658 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 387344002659 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 387344002660 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 387344002661 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 387344002662 RimM N-terminal domain; Region: RimM; pfam01782 387344002663 PRC-barrel domain; Region: PRC; pfam05239 387344002664 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 387344002665 KH domain; Region: KH_4; pfam13083 387344002666 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 387344002667 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 387344002668 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 387344002669 metal ion-dependent adhesion site (MIDAS); other site 387344002670 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 387344002671 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 387344002672 Walker A motif; other site 387344002673 ATP binding site [chemical binding]; other site 387344002674 Walker B motif; other site 387344002675 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 387344002676 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 387344002677 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 387344002678 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 387344002679 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 387344002680 motif II; other site 387344002681 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 387344002682 putative DNA-binding protein; Validated; Region: PRK00118 387344002683 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 387344002684 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 387344002685 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 387344002686 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 387344002687 P loop; other site 387344002688 GTP binding site [chemical binding]; other site 387344002689 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 387344002690 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 387344002691 Walker A/P-loop; other site 387344002692 ATP binding site [chemical binding]; other site 387344002693 Q-loop/lid; other site 387344002694 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 387344002695 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 387344002696 ABC transporter signature motif; other site 387344002697 Walker B; other site 387344002698 D-loop; other site 387344002699 H-loop/switch region; other site 387344002700 ribonuclease III; Reviewed; Region: rnc; PRK00102 387344002701 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 387344002702 dimerization interface [polypeptide binding]; other site 387344002703 active site 387344002704 metal binding site [ion binding]; metal-binding site 387344002705 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 387344002706 dsRNA binding site [nucleotide binding]; other site 387344002707 acyl carrier protein; Provisional; Region: acpP; PRK00982 387344002708 putative phosphate acyltransferase; Provisional; Region: PRK05331 387344002709 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 387344002710 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 387344002711 generic binding surface II; other site 387344002712 ssDNA binding site; other site 387344002713 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 387344002714 ATP binding site [chemical binding]; other site 387344002715 putative Mg++ binding site [ion binding]; other site 387344002716 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 387344002717 nucleotide binding region [chemical binding]; other site 387344002718 ATP-binding site [chemical binding]; other site 387344002719 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 387344002720 DAK2 domain; Region: Dak2; pfam02734 387344002721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 387344002722 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 387344002723 Thiamine pyrophosphokinase; Region: TPK; cd07995 387344002724 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 387344002725 active site 387344002726 dimerization interface [polypeptide binding]; other site 387344002727 thiamine binding site [chemical binding]; other site 387344002728 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 387344002729 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 387344002730 substrate binding site [chemical binding]; other site 387344002731 hexamer interface [polypeptide binding]; other site 387344002732 metal binding site [ion binding]; metal-binding site 387344002733 GTPase RsgA; Reviewed; Region: PRK00098 387344002734 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 387344002735 RNA binding site [nucleotide binding]; other site 387344002736 homodimer interface [polypeptide binding]; other site 387344002737 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 387344002738 GTPase/Zn-binding domain interface [polypeptide binding]; other site 387344002739 GTP/Mg2+ binding site [chemical binding]; other site 387344002740 G4 box; other site 387344002741 G5 box; other site 387344002742 G1 box; other site 387344002743 Switch I region; other site 387344002744 G2 box; other site 387344002745 G3 box; other site 387344002746 Switch II region; other site 387344002747 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 387344002748 Catalytic domain of Protein Kinases; Region: PKc; cd00180 387344002749 active site 387344002750 ATP binding site [chemical binding]; other site 387344002751 substrate binding site [chemical binding]; other site 387344002752 activation loop (A-loop); other site 387344002753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 387344002754 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 387344002755 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 387344002756 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 387344002757 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 387344002758 active site 387344002759 16S rRNA methyltransferase B; Provisional; Region: PRK14902 387344002760 NusB family; Region: NusB; pfam01029 387344002761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 387344002762 S-adenosylmethionine binding site [chemical binding]; other site 387344002763 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 387344002764 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 387344002765 putative active site [active] 387344002766 substrate binding site [chemical binding]; other site 387344002767 putative cosubstrate binding site; other site 387344002768 catalytic site [active] 387344002769 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 387344002770 substrate binding site [chemical binding]; other site 387344002771 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 387344002772 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 387344002773 ATP binding site [chemical binding]; other site 387344002774 putative Mg++ binding site [ion binding]; other site 387344002775 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 387344002776 nucleotide binding region [chemical binding]; other site 387344002777 ATP-binding site [chemical binding]; other site 387344002778 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 387344002779 Flavoprotein; Region: Flavoprotein; pfam02441 387344002780 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 387344002781 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 387344002782 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 387344002783 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 387344002784 Walker A/P-loop; other site 387344002785 ATP binding site [chemical binding]; other site 387344002786 Q-loop/lid; other site 387344002787 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 387344002788 ABC transporter signature motif; other site 387344002789 Walker B; other site 387344002790 D-loop; other site 387344002791 H-loop/switch region; other site 387344002792 arginine repressor; Provisional; Region: PRK04280 387344002793 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 387344002794 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 387344002795 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 387344002796 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 387344002797 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 387344002798 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 387344002799 substrate binding pocket [chemical binding]; other site 387344002800 chain length determination region; other site 387344002801 substrate-Mg2+ binding site; other site 387344002802 catalytic residues [active] 387344002803 aspartate-rich region 1; other site 387344002804 active site lid residues [active] 387344002805 aspartate-rich region 2; other site 387344002806 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 387344002807 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 387344002808 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 387344002809 generic binding surface II; other site 387344002810 generic binding surface I; other site 387344002811 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 387344002812 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 387344002813 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 387344002814 homodimer interface [polypeptide binding]; other site 387344002815 NADP binding site [chemical binding]; other site 387344002816 substrate binding site [chemical binding]; other site 387344002817 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 387344002818 putative RNA binding site [nucleotide binding]; other site 387344002819 Asp23 family; Region: Asp23; pfam03780 387344002820 elongation factor P; Validated; Region: PRK00529 387344002821 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 387344002822 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 387344002823 RNA binding site [nucleotide binding]; other site 387344002824 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 387344002825 RNA binding site [nucleotide binding]; other site 387344002826 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 387344002827 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 387344002828 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 387344002829 active site 387344002830 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 387344002831 Protein of unknown function (DUF464); Region: DUF464; pfam04327 387344002832 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 387344002833 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 387344002834 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 387344002835 dUTPase; Region: dUTPase_2; pfam08761 387344002836 active site 387344002837 homodimer interface [polypeptide binding]; other site 387344002838 metal binding site [ion binding]; metal-binding site 387344002839 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 387344002840 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 387344002841 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 387344002842 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 387344002843 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 387344002844 DNA binding residues [nucleotide binding] 387344002845 putative dimer interface [polypeptide binding]; other site 387344002846 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 387344002847 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 387344002848 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 387344002849 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 387344002850 active site 387344002851 catalytic site [active] 387344002852 metal binding site [ion binding]; metal-binding site 387344002853 dimer interface [polypeptide binding]; other site 387344002854 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 387344002855 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 387344002856 active site residue [active] 387344002857 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 387344002858 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 387344002859 nucleotide binding site [chemical binding]; other site 387344002860 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 387344002861 Rhomboid family; Region: Rhomboid; pfam01694 387344002862 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 387344002863 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 387344002864 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 387344002865 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 387344002866 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 387344002867 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 387344002868 Domain of unknown function (DUF378); Region: DUF378; pfam04070 387344002869 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 387344002870 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 387344002871 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 387344002872 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 387344002873 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 387344002874 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 387344002875 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 387344002876 Sugar specificity; other site 387344002877 Pyrimidine base specificity; other site 387344002878 ATP-binding site [chemical binding]; other site 387344002879 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 387344002880 YceG-like family; Region: YceG; pfam02618 387344002881 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 387344002882 dimerization interface [polypeptide binding]; other site 387344002883 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 387344002884 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 387344002885 putative tRNA-binding site [nucleotide binding]; other site 387344002886 B3/4 domain; Region: B3_4; pfam03483 387344002887 tRNA synthetase B5 domain; Region: B5; smart00874 387344002888 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 387344002889 dimer interface [polypeptide binding]; other site 387344002890 motif 1; other site 387344002891 motif 3; other site 387344002892 motif 2; other site 387344002893 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 387344002894 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 387344002895 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 387344002896 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 387344002897 dimer interface [polypeptide binding]; other site 387344002898 motif 1; other site 387344002899 active site 387344002900 motif 2; other site 387344002901 motif 3; other site 387344002902 Predicted transcriptional regulators [Transcription]; Region: COG1733 387344002903 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 387344002904 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 387344002905 Zn2+ binding site [ion binding]; other site 387344002906 Mg2+ binding site [ion binding]; other site 387344002907 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 387344002908 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 387344002909 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 387344002910 Acylphosphatase; Region: Acylphosphatase; pfam00708 387344002911 OxaA-like protein precursor; Provisional; Region: PRK02463 387344002912 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 387344002913 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 387344002914 sensory histidine kinase CreC; Provisional; Region: PRK11100 387344002915 HAMP domain; Region: HAMP; pfam00672 387344002916 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 387344002917 dimer interface [polypeptide binding]; other site 387344002918 phosphorylation site [posttranslational modification] 387344002919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 387344002920 ATP binding site [chemical binding]; other site 387344002921 Mg2+ binding site [ion binding]; other site 387344002922 G-X-G motif; other site 387344002923 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 387344002924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 387344002925 active site 387344002926 phosphorylation site [posttranslational modification] 387344002927 intermolecular recognition site; other site 387344002928 dimerization interface [polypeptide binding]; other site 387344002929 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 387344002930 DNA binding site [nucleotide binding] 387344002931 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 387344002932 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 387344002933 NAD binding site [chemical binding]; other site 387344002934 substrate binding site [chemical binding]; other site 387344002935 catalytic Zn binding site [ion binding]; other site 387344002936 tetramer interface [polypeptide binding]; other site 387344002937 structural Zn binding site [ion binding]; other site 387344002938 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 387344002939 active site 387344002940 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 387344002941 dimerization interface [polypeptide binding]; other site 387344002942 putative DNA binding site [nucleotide binding]; other site 387344002943 putative Zn2+ binding site [ion binding]; other site 387344002944 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 387344002945 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 387344002946 active site 387344002947 motif I; other site 387344002948 motif II; other site 387344002949 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 387344002950 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 387344002951 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 387344002952 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 387344002953 hypothetical protein; Provisional; Region: PRK13670 387344002954 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 387344002955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 387344002956 S-adenosylmethionine binding site [chemical binding]; other site 387344002957 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 387344002958 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 387344002959 Zn2+ binding site [ion binding]; other site 387344002960 Mg2+ binding site [ion binding]; other site 387344002961 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 387344002962 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 387344002963 active site 387344002964 (T/H)XGH motif; other site 387344002965 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 387344002966 GTPase YqeH; Provisional; Region: PRK13796 387344002967 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 387344002968 GTP/Mg2+ binding site [chemical binding]; other site 387344002969 G4 box; other site 387344002970 G5 box; other site 387344002971 G1 box; other site 387344002972 Switch I region; other site 387344002973 G2 box; other site 387344002974 G3 box; other site 387344002975 Switch II region; other site 387344002976 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 387344002977 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 387344002978 active site 387344002979 motif I; other site 387344002980 motif II; other site 387344002981 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 387344002982 23S rRNA binding site [nucleotide binding]; other site 387344002983 L21 binding site [polypeptide binding]; other site 387344002984 L13 binding site [polypeptide binding]; other site 387344002985 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 387344002986 translation initiation factor IF-3; Region: infC; TIGR00168 387344002987 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 387344002988 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 387344002989 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 387344002990 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 387344002991 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 387344002992 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 387344002993 active site 387344002994 dimer interface [polypeptide binding]; other site 387344002995 motif 1; other site 387344002996 motif 2; other site 387344002997 motif 3; other site 387344002998 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 387344002999 anticodon binding site; other site 387344003000 primosomal protein DnaI; Reviewed; Region: PRK08939 387344003001 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 387344003002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 387344003003 Walker A motif; other site 387344003004 ATP binding site [chemical binding]; other site 387344003005 Walker B motif; other site 387344003006 arginine finger; other site 387344003007 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 387344003008 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 387344003009 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 387344003010 ATP cone domain; Region: ATP-cone; pfam03477 387344003011 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 387344003012 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 387344003013 CoA-binding site [chemical binding]; other site 387344003014 ATP-binding [chemical binding]; other site 387344003015 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 387344003016 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 387344003017 DNA binding site [nucleotide binding] 387344003018 catalytic residue [active] 387344003019 H2TH interface [polypeptide binding]; other site 387344003020 putative catalytic residues [active] 387344003021 turnover-facilitating residue; other site 387344003022 intercalation triad [nucleotide binding]; other site 387344003023 8OG recognition residue [nucleotide binding]; other site 387344003024 putative reading head residues; other site 387344003025 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 387344003026 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 387344003027 DNA polymerase I; Provisional; Region: PRK05755 387344003028 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 387344003029 active site 387344003030 metal binding site 1 [ion binding]; metal-binding site 387344003031 putative 5' ssDNA interaction site; other site 387344003032 metal binding site 3; metal-binding site 387344003033 metal binding site 2 [ion binding]; metal-binding site 387344003034 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 387344003035 putative DNA binding site [nucleotide binding]; other site 387344003036 putative metal binding site [ion binding]; other site 387344003037 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 387344003038 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 387344003039 active site 387344003040 DNA binding site [nucleotide binding] 387344003041 catalytic site [active] 387344003042 guanine deaminase; Region: guan_deamin; TIGR02967 387344003043 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 387344003044 active site 387344003045 xanthine permease; Region: pbuX; TIGR03173 387344003046 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 387344003047 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 387344003048 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 387344003049 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 387344003050 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 387344003051 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 387344003052 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 387344003053 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 387344003054 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 387344003055 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 387344003056 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 387344003057 putative tRNA-binding site [nucleotide binding]; other site 387344003058 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 387344003059 catalytic residues [active] 387344003060 Predicted small secreted protein [Function unknown]; Region: COG5584 387344003061 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 387344003062 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 387344003063 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 387344003064 hexamer interface [polypeptide binding]; other site 387344003065 ligand binding site [chemical binding]; other site 387344003066 putative active site [active] 387344003067 NAD(P) binding site [chemical binding]; other site 387344003068 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 387344003069 Ligand Binding Site [chemical binding]; other site 387344003070 dipeptidase PepV; Reviewed; Region: PRK07318 387344003071 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 387344003072 active site 387344003073 metal binding site [ion binding]; metal-binding site 387344003074 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 387344003075 putative substrate binding site [chemical binding]; other site 387344003076 putative ATP binding site [chemical binding]; other site 387344003077 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 387344003078 RNA binding surface [nucleotide binding]; other site 387344003079 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 387344003080 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 387344003081 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 387344003082 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 387344003083 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 387344003084 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 387344003085 Walker A/P-loop; other site 387344003086 ATP binding site [chemical binding]; other site 387344003087 Q-loop/lid; other site 387344003088 ABC transporter signature motif; other site 387344003089 Walker B; other site 387344003090 D-loop; other site 387344003091 H-loop/switch region; other site 387344003092 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 387344003093 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 387344003094 HIGH motif; other site 387344003095 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 387344003096 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 387344003097 active site 387344003098 KMSKS motif; other site 387344003099 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 387344003100 tRNA binding surface [nucleotide binding]; other site 387344003101 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 387344003102 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 387344003103 active site 387344003104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 387344003105 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 387344003106 N-glycosyltransferase; Provisional; Region: PRK11204 387344003107 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 387344003108 DXD motif; other site 387344003109 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 387344003110 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 387344003111 non-specific DNA binding site [nucleotide binding]; other site 387344003112 salt bridge; other site 387344003113 sequence-specific DNA binding site [nucleotide binding]; other site 387344003114 Domain of unknown function (DUF955); Region: DUF955; cl01076 387344003115 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 387344003116 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 387344003117 active site 387344003118 Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890 387344003119 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 387344003120 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 387344003121 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 387344003122 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 387344003123 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 387344003124 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 387344003125 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 387344003126 Peptidase family M23; Region: Peptidase_M23; pfam01551 387344003127 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 387344003128 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 387344003129 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 387344003130 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 387344003131 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 387344003132 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 387344003133 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 387344003134 Phage terminase large subunit; Region: Terminase_3; cl12054 387344003135 Terminase-like family; Region: Terminase_6; pfam03237 387344003136 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 387344003137 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 387344003138 active site 387344003139 DNA binding site [nucleotide binding] 387344003140 Int/Topo IB signature motif; other site 387344003141 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 387344003142 Terminase small subunit; Region: Terminase_2; pfam03592 387344003143 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 387344003144 2-isopropylmalate synthase/homocitrate synthase family protein; Region: LeuA_rel; TIGR00977 387344003145 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 387344003146 Protein of unknown function (DUF968); Region: DUF968; pfam06147 387344003147 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 387344003148 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 387344003149 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 387344003150 Walker A motif; other site 387344003151 ATP binding site [chemical binding]; other site 387344003152 Walker B motif; other site 387344003153 Helix-turn-helix domain; Region: HTH_36; pfam13730 387344003154 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 387344003155 Protein of unknown function (DUF669); Region: DUF669; pfam05037 387344003156 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 387344003157 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 387344003158 AAA domain; Region: AAA_24; pfam13479 387344003159 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 387344003160 ORF6N domain; Region: ORF6N; pfam10543 387344003161 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 387344003162 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 387344003163 non-specific DNA binding site [nucleotide binding]; other site 387344003164 salt bridge; other site 387344003165 sequence-specific DNA binding site [nucleotide binding]; other site 387344003166 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 387344003167 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 387344003168 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 387344003169 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 387344003170 DNA binding site [nucleotide binding] 387344003171 active site 387344003172 Int/Topo IB signature motif; other site 387344003173 catalytic residues [active] 387344003174 adaptor protein; Provisional; Region: PRK02315 387344003175 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 387344003176 ArsC family; Region: ArsC; pfam03960 387344003177 putative catalytic residues [active] 387344003178 thiol/disulfide switch; other site 387344003179 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 387344003180 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 387344003181 AAA ATPase domain; Region: AAA_16; pfam13191 387344003182 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 387344003183 Uncharacterized conserved protein [Function unknown]; Region: COG3410 387344003184 general stress protein 13; Validated; Region: PRK08059 387344003185 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 387344003186 RNA binding site [nucleotide binding]; other site 387344003187 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 387344003188 active site 387344003189 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 387344003190 tetramer interfaces [polypeptide binding]; other site 387344003191 binuclear metal-binding site [ion binding]; other site 387344003192 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 387344003193 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 387344003194 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 387344003195 classical (c) SDRs; Region: SDR_c; cd05233 387344003196 NAD(P) binding site [chemical binding]; other site 387344003197 active site 387344003198 amino acid transporter; Region: 2A0306; TIGR00909 387344003199 Collagen binding domain; Region: Collagen_bind; pfam05737 387344003200 Cna protein B-type domain; Region: Cna_B; pfam05738 387344003201 legume lectins; Region: lectin_L-type; cl14058 387344003202 homotetramer interaction site [polypeptide binding]; other site 387344003203 carbohydrate binding site [chemical binding]; other site 387344003204 metal binding site [ion binding]; metal-binding site 387344003205 WxL domain surface cell wall-binding; Region: WxL; pfam13731 387344003206 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 387344003207 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 387344003208 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 387344003209 active site 387344003210 motif I; other site 387344003211 motif II; other site 387344003212 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 387344003213 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 387344003214 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 387344003215 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 387344003216 active site 387344003217 metal binding site [ion binding]; metal-binding site 387344003218 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 387344003219 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 387344003220 putative active site [active] 387344003221 putative metal binding site [ion binding]; other site 387344003222 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 387344003223 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 387344003224 active site 387344003225 catalytic tetrad [active] 387344003226 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 387344003227 propionate/acetate kinase; Provisional; Region: PRK12379 387344003228 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 387344003229 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 387344003230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 387344003231 S-adenosylmethionine binding site [chemical binding]; other site 387344003232 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 387344003233 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 387344003234 Type II/IV secretion system protein; Region: T2SE; pfam00437 387344003235 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 387344003236 Walker A motif; other site 387344003237 ATP binding site [chemical binding]; other site 387344003238 Walker B motif; other site 387344003239 hypothetical protein; Validated; Region: PRK00110 387344003240 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 387344003241 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 387344003242 substrate binding pocket [chemical binding]; other site 387344003243 membrane-bound complex binding site; other site 387344003244 hinge residues; other site 387344003245 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 387344003246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 387344003247 dimer interface [polypeptide binding]; other site 387344003248 conserved gate region; other site 387344003249 putative PBP binding loops; other site 387344003250 ABC-ATPase subunit interface; other site 387344003251 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 387344003252 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 387344003253 Walker A/P-loop; other site 387344003254 ATP binding site [chemical binding]; other site 387344003255 Q-loop/lid; other site 387344003256 ABC transporter signature motif; other site 387344003257 Walker B; other site 387344003258 D-loop; other site 387344003259 H-loop/switch region; other site 387344003260 catabolite control protein A; Region: ccpA; TIGR01481 387344003261 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 387344003262 DNA binding site [nucleotide binding] 387344003263 domain linker motif; other site 387344003264 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 387344003265 dimerization interface [polypeptide binding]; other site 387344003266 effector binding site; other site 387344003267 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 387344003268 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 387344003269 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 387344003270 active site 387344003271 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 387344003272 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 387344003273 Mechanosensitive ion channel; Region: MS_channel; pfam00924 387344003274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344003275 Major Facilitator Superfamily; Region: MFS_1; pfam07690 387344003276 putative substrate translocation pore; other site 387344003277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344003278 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 387344003279 dimerization interface [polypeptide binding]; other site 387344003280 putative DNA binding site [nucleotide binding]; other site 387344003281 putative Zn2+ binding site [ion binding]; other site 387344003282 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 387344003283 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 387344003284 active site 387344003285 metal binding site [ion binding]; metal-binding site 387344003286 homotetramer interface [polypeptide binding]; other site 387344003287 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 387344003288 active site 387344003289 dimerization interface [polypeptide binding]; other site 387344003290 glutamate racemase; Provisional; Region: PRK00865 387344003291 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 387344003292 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 387344003293 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 387344003294 catalytic residues [active] 387344003295 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 387344003296 MutS domain III; Region: MutS_III; pfam05192 387344003297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 387344003298 Walker A/P-loop; other site 387344003299 ATP binding site [chemical binding]; other site 387344003300 Q-loop/lid; other site 387344003301 ABC transporter signature motif; other site 387344003302 Walker B; other site 387344003303 D-loop; other site 387344003304 H-loop/switch region; other site 387344003305 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 387344003306 Smr domain; Region: Smr; pfam01713 387344003307 Colicin V production protein; Region: Colicin_V; pfam02674 387344003308 Cell division protein ZapA; Region: ZapA; pfam05164 387344003309 hypothetical protein; Provisional; Region: PRK13678 387344003310 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 387344003311 hypothetical protein; Provisional; Region: PRK05473 387344003312 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 387344003313 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 387344003314 motif 1; other site 387344003315 active site 387344003316 motif 2; other site 387344003317 motif 3; other site 387344003318 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 387344003319 DHHA1 domain; Region: DHHA1; pfam02272 387344003320 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 387344003321 DEAD-like helicases superfamily; Region: DEXDc; smart00487 387344003322 ATP binding site [chemical binding]; other site 387344003323 Mg++ binding site [ion binding]; other site 387344003324 motif III; other site 387344003325 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 387344003326 nucleotide binding region [chemical binding]; other site 387344003327 ATP-binding site [chemical binding]; other site 387344003328 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 387344003329 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 387344003330 DHH family; Region: DHH; pfam01368 387344003331 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 387344003332 active site 387344003333 DNA polymerase IV; Validated; Region: PRK02406 387344003334 DNA binding site [nucleotide binding] 387344003335 Preprotein translocase subunit; Region: YajC; pfam02699 387344003336 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 387344003337 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 387344003338 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 387344003339 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 387344003340 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 387344003341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 387344003342 Walker A motif; other site 387344003343 ATP binding site [chemical binding]; other site 387344003344 Walker B motif; other site 387344003345 arginine finger; other site 387344003346 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 387344003347 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 387344003348 RuvA N terminal domain; Region: RuvA_N; pfam01330 387344003349 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 387344003350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 387344003351 ATP binding site [chemical binding]; other site 387344003352 Mg2+ binding site [ion binding]; other site 387344003353 G-X-G motif; other site 387344003354 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 387344003355 ATP binding site [chemical binding]; other site 387344003356 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 387344003357 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 387344003358 MutS domain I; Region: MutS_I; pfam01624 387344003359 MutS domain II; Region: MutS_II; pfam05188 387344003360 MutS domain III; Region: MutS_III; pfam05192 387344003361 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 387344003362 Walker A/P-loop; other site 387344003363 ATP binding site [chemical binding]; other site 387344003364 Q-loop/lid; other site 387344003365 ABC transporter signature motif; other site 387344003366 Walker B; other site 387344003367 D-loop; other site 387344003368 H-loop/switch region; other site 387344003369 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 387344003370 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 387344003371 putative active site [active] 387344003372 metal binding site [ion binding]; metal-binding site 387344003373 homodimer binding site [polypeptide binding]; other site 387344003374 phosphodiesterase; Provisional; Region: PRK12704 387344003375 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 387344003376 Zn2+ binding site [ion binding]; other site 387344003377 Mg2+ binding site [ion binding]; other site 387344003378 recombinase A; Provisional; Region: recA; PRK09354 387344003379 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 387344003380 hexamer interface [polypeptide binding]; other site 387344003381 Walker A motif; other site 387344003382 ATP binding site [chemical binding]; other site 387344003383 Walker B motif; other site 387344003384 competence damage-inducible protein A; Provisional; Region: PRK00549 387344003385 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 387344003386 putative MPT binding site; other site 387344003387 Competence-damaged protein; Region: CinA; pfam02464 387344003388 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 387344003389 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 387344003390 Helix-turn-helix domain; Region: HTH_25; pfam13413 387344003391 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 387344003392 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 387344003393 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 387344003394 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 387344003395 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 387344003396 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 387344003397 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 387344003398 substrate binding pocket [chemical binding]; other site 387344003399 membrane-bound complex binding site; other site 387344003400 hinge residues; other site 387344003401 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 387344003402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 387344003403 dimer interface [polypeptide binding]; other site 387344003404 conserved gate region; other site 387344003405 putative PBP binding loops; other site 387344003406 ABC-ATPase subunit interface; other site 387344003407 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 387344003408 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 387344003409 Switch I; other site 387344003410 Switch II; other site 387344003411 septum formation inhibitor; Reviewed; Region: minC; PRK00513 387344003412 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 387344003413 rod shape-determining protein MreD; Region: MreD; cl01087 387344003414 rod shape-determining protein MreC; Provisional; Region: PRK13922 387344003415 rod shape-determining protein MreC; Region: MreC; pfam04085 387344003416 rod shape-determining protein MreB; Provisional; Region: PRK13927 387344003417 MreB and similar proteins; Region: MreB_like; cd10225 387344003418 nucleotide binding site [chemical binding]; other site 387344003419 Mg binding site [ion binding]; other site 387344003420 putative protofilament interaction site [polypeptide binding]; other site 387344003421 RodZ interaction site [polypeptide binding]; other site 387344003422 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 387344003423 MPN+ (JAMM) motif; other site 387344003424 Zinc-binding site [ion binding]; other site 387344003425 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 387344003426 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 387344003427 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 387344003428 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 387344003429 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 387344003430 active site 387344003431 HIGH motif; other site 387344003432 nucleotide binding site [chemical binding]; other site 387344003433 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 387344003434 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 387344003435 active site 387344003436 KMSKS motif; other site 387344003437 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 387344003438 tRNA binding surface [nucleotide binding]; other site 387344003439 anticodon binding site; other site 387344003440 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 387344003441 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 387344003442 dimer interface [polypeptide binding]; other site 387344003443 catalytic triad [active] 387344003444 peroxidatic and resolving cysteines [active] 387344003445 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 387344003446 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 387344003447 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 387344003448 Ligand Binding Site [chemical binding]; other site 387344003449 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 387344003450 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 387344003451 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 387344003452 catalytic residue [active] 387344003453 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 387344003454 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 387344003455 GAF domain; Region: GAF_2; pfam13185 387344003456 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 387344003457 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 387344003458 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 387344003459 RNA binding surface [nucleotide binding]; other site 387344003460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 387344003461 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 387344003462 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 387344003463 recombination factor protein RarA; Reviewed; Region: PRK13342 387344003464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 387344003465 Walker A motif; other site 387344003466 ATP binding site [chemical binding]; other site 387344003467 Walker B motif; other site 387344003468 arginine finger; other site 387344003469 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 387344003470 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 387344003471 Ligand Binding Site [chemical binding]; other site 387344003472 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 387344003473 non-specific DNA binding site [nucleotide binding]; other site 387344003474 salt bridge; other site 387344003475 sequence-specific DNA binding site [nucleotide binding]; other site 387344003476 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 387344003477 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 387344003478 putative active site [active] 387344003479 catalytic site [active] 387344003480 putative metal binding site [ion binding]; other site 387344003481 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 387344003482 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 387344003483 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 387344003484 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 387344003485 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 387344003486 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 387344003487 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 387344003488 lipoyl attachment site [posttranslational modification]; other site 387344003489 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 387344003490 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 387344003491 Haemolytic domain; Region: Haemolytic; cl00506 387344003492 rod shape-determining protein MreB; Provisional; Region: PRK13930 387344003493 MreB and similar proteins; Region: MreB_like; cd10225 387344003494 nucleotide binding site [chemical binding]; other site 387344003495 Mg binding site [ion binding]; other site 387344003496 putative protofilament interaction site [polypeptide binding]; other site 387344003497 RodZ interaction site [polypeptide binding]; other site 387344003498 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 387344003499 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 387344003500 hinge; other site 387344003501 active site 387344003502 Protein of unknown function (DUF1146); Region: DUF1146; pfam06612 387344003503 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 387344003504 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 387344003505 gamma subunit interface [polypeptide binding]; other site 387344003506 epsilon subunit interface [polypeptide binding]; other site 387344003507 LBP interface [polypeptide binding]; other site 387344003508 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 387344003509 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 387344003510 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 387344003511 alpha subunit interaction interface [polypeptide binding]; other site 387344003512 Walker A motif; other site 387344003513 ATP binding site [chemical binding]; other site 387344003514 Walker B motif; other site 387344003515 inhibitor binding site; inhibition site 387344003516 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 387344003517 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 387344003518 core domain interface [polypeptide binding]; other site 387344003519 delta subunit interface [polypeptide binding]; other site 387344003520 epsilon subunit interface [polypeptide binding]; other site 387344003521 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 387344003522 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 387344003523 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 387344003524 beta subunit interaction interface [polypeptide binding]; other site 387344003525 Walker A motif; other site 387344003526 ATP binding site [chemical binding]; other site 387344003527 Walker B motif; other site 387344003528 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 387344003529 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 387344003530 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 387344003531 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 387344003532 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 387344003533 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 387344003534 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 387344003535 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 387344003536 active site 387344003537 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 387344003538 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 387344003539 dimer interface [polypeptide binding]; other site 387344003540 active site 387344003541 glycine-pyridoxal phosphate binding site [chemical binding]; other site 387344003542 folate binding site [chemical binding]; other site 387344003543 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 387344003544 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 387344003545 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 387344003546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 387344003547 S-adenosylmethionine binding site [chemical binding]; other site 387344003548 peptide chain release factor 1; Validated; Region: prfA; PRK00591 387344003549 This domain is found in peptide chain release factors; Region: PCRF; smart00937 387344003550 RF-1 domain; Region: RF-1; pfam00472 387344003551 thymidine kinase; Provisional; Region: PRK04296 387344003552 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 387344003553 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 387344003554 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 387344003555 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 387344003556 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 387344003557 catalytic triad [active] 387344003558 Beta-lactamase; Region: Beta-lactamase; pfam00144 387344003559 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 387344003560 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 387344003561 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 387344003562 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 387344003563 Walker A/P-loop; other site 387344003564 ATP binding site [chemical binding]; other site 387344003565 Q-loop/lid; other site 387344003566 ABC transporter signature motif; other site 387344003567 Walker B; other site 387344003568 D-loop; other site 387344003569 H-loop/switch region; other site 387344003570 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 387344003571 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 387344003572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 387344003573 Walker A/P-loop; other site 387344003574 ATP binding site [chemical binding]; other site 387344003575 Q-loop/lid; other site 387344003576 ABC transporter signature motif; other site 387344003577 Walker B; other site 387344003578 D-loop; other site 387344003579 H-loop/switch region; other site 387344003580 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 387344003581 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 387344003582 metal binding site [ion binding]; metal-binding site 387344003583 active site 387344003584 I-site; other site 387344003585 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 387344003586 Helix-turn-helix domain; Region: HTH_38; pfam13936 387344003587 Integrase core domain; Region: rve; pfam00665 387344003588 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 387344003589 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 387344003590 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 387344003591 transmembrane helices; other site 387344003592 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 387344003593 active site 387344003594 conformational flexibility of ligand binding pocket; other site 387344003595 ADP-ribosylating toxin turn-turn motif; other site 387344003596 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 387344003597 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 387344003598 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 387344003599 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 387344003600 TspO/MBR family; Region: TspO_MBR; pfam03073 387344003601 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 387344003602 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 387344003603 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 387344003604 active site 387344003605 dimer interface [polypeptide binding]; other site 387344003606 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 387344003607 dimer interface [polypeptide binding]; other site 387344003608 active site 387344003609 Sugar transport protein; Region: Sugar_transport; pfam06800 387344003610 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 387344003611 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 387344003612 putative RNA binding site [nucleotide binding]; other site 387344003613 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 387344003614 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 387344003615 dimerization interface [polypeptide binding]; other site 387344003616 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 387344003617 dimer interface [polypeptide binding]; other site 387344003618 phosphorylation site [posttranslational modification] 387344003619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 387344003620 ATP binding site [chemical binding]; other site 387344003621 Mg2+ binding site [ion binding]; other site 387344003622 G-X-G motif; other site 387344003623 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 387344003624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 387344003625 active site 387344003626 phosphorylation site [posttranslational modification] 387344003627 intermolecular recognition site; other site 387344003628 dimerization interface [polypeptide binding]; other site 387344003629 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 387344003630 DNA binding site [nucleotide binding] 387344003631 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 387344003632 Helix-turn-helix domain; Region: HTH_38; pfam13936 387344003633 Integrase core domain; Region: rve; pfam00665 387344003634 GTP-binding protein LepA; Provisional; Region: PRK05433 387344003635 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 387344003636 G1 box; other site 387344003637 putative GEF interaction site [polypeptide binding]; other site 387344003638 GTP/Mg2+ binding site [chemical binding]; other site 387344003639 Switch I region; other site 387344003640 G2 box; other site 387344003641 G3 box; other site 387344003642 Switch II region; other site 387344003643 G4 box; other site 387344003644 G5 box; other site 387344003645 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 387344003646 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 387344003647 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 387344003648 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 387344003649 DltD N-terminal region; Region: DltD_N; pfam04915 387344003650 DltD central region; Region: DltD_M; pfam04918 387344003651 DltD C-terminal region; Region: DltD_C; pfam04914 387344003652 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 387344003653 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 387344003654 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 387344003655 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 387344003656 acyl-activating enzyme (AAE) consensus motif; other site 387344003657 AMP binding site [chemical binding]; other site 387344003658 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 387344003659 chaperone protein DnaJ; Provisional; Region: PRK14276 387344003660 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 387344003661 HSP70 interaction site [polypeptide binding]; other site 387344003662 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 387344003663 substrate binding site [polypeptide binding]; other site 387344003664 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 387344003665 Zn binding sites [ion binding]; other site 387344003666 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 387344003667 dimer interface [polypeptide binding]; other site 387344003668 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 387344003669 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 387344003670 nucleotide binding site [chemical binding]; other site 387344003671 GrpE; Region: GrpE; pfam01025 387344003672 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 387344003673 dimer interface [polypeptide binding]; other site 387344003674 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 387344003675 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 387344003676 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 387344003677 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 387344003678 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 387344003679 active site 387344003680 Riboflavin kinase; Region: Flavokinase; smart00904 387344003681 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 387344003682 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 387344003683 RNA binding site [nucleotide binding]; other site 387344003684 active site 387344003685 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 387344003686 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 387344003687 translation initiation factor IF-2; Region: IF-2; TIGR00487 387344003688 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 387344003689 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 387344003690 G1 box; other site 387344003691 putative GEF interaction site [polypeptide binding]; other site 387344003692 GTP/Mg2+ binding site [chemical binding]; other site 387344003693 Switch I region; other site 387344003694 G2 box; other site 387344003695 G3 box; other site 387344003696 Switch II region; other site 387344003697 G4 box; other site 387344003698 G5 box; other site 387344003699 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 387344003700 Translation-initiation factor 2; Region: IF-2; pfam11987 387344003701 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 387344003702 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 387344003703 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 387344003704 putative RNA binding cleft [nucleotide binding]; other site 387344003705 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 387344003706 NusA N-terminal domain; Region: NusA_N; pfam08529 387344003707 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 387344003708 RNA binding site [nucleotide binding]; other site 387344003709 homodimer interface [polypeptide binding]; other site 387344003710 NusA-like KH domain; Region: KH_5; pfam13184 387344003711 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 387344003712 G-X-X-G motif; other site 387344003713 ribosome maturation protein RimP; Reviewed; Region: PRK00092 387344003714 Sm and related proteins; Region: Sm_like; cl00259 387344003715 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 387344003716 putative oligomer interface [polypeptide binding]; other site 387344003717 putative RNA binding site [nucleotide binding]; other site 387344003718 DNA polymerase III PolC; Validated; Region: polC; PRK00448 387344003719 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 387344003720 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 387344003721 generic binding surface II; other site 387344003722 generic binding surface I; other site 387344003723 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 387344003724 active site 387344003725 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 387344003726 active site 387344003727 catalytic site [active] 387344003728 substrate binding site [chemical binding]; other site 387344003729 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 387344003730 prolyl-tRNA synthetase; Provisional; Region: PRK09194 387344003731 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 387344003732 dimer interface [polypeptide binding]; other site 387344003733 motif 1; other site 387344003734 active site 387344003735 motif 2; other site 387344003736 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 387344003737 putative deacylase active site [active] 387344003738 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 387344003739 active site 387344003740 motif 3; other site 387344003741 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 387344003742 anticodon binding site; other site 387344003743 RIP metalloprotease RseP; Region: TIGR00054 387344003744 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 387344003745 active site 387344003746 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 387344003747 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 387344003748 protein binding site [polypeptide binding]; other site 387344003749 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 387344003750 putative substrate binding region [chemical binding]; other site 387344003751 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 387344003752 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 387344003753 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 387344003754 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 387344003755 catalytic residue [active] 387344003756 putative FPP diphosphate binding site; other site 387344003757 putative FPP binding hydrophobic cleft; other site 387344003758 dimer interface [polypeptide binding]; other site 387344003759 putative IPP diphosphate binding site; other site 387344003760 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 387344003761 putative nucleotide binding site [chemical binding]; other site 387344003762 uridine monophosphate binding site [chemical binding]; other site 387344003763 homohexameric interface [polypeptide binding]; other site 387344003764 elongation factor Ts; Provisional; Region: tsf; PRK09377 387344003765 UBA/TS-N domain; Region: UBA; pfam00627 387344003766 Elongation factor TS; Region: EF_TS; pfam00889 387344003767 Elongation factor TS; Region: EF_TS; pfam00889 387344003768 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 387344003769 rRNA interaction site [nucleotide binding]; other site 387344003770 S8 interaction site; other site 387344003771 putative laminin-1 binding site; other site 387344003772 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 387344003773 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 387344003774 motif II; other site 387344003775 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 387344003776 D-lactate dehydrogenase; Validated; Region: PRK08605 387344003777 homodimer interface [polypeptide binding]; other site 387344003778 ligand binding site [chemical binding]; other site 387344003779 NAD binding site [chemical binding]; other site 387344003780 catalytic site [active] 387344003781 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 387344003782 GIY-YIG motif/motif A; other site 387344003783 putative active site [active] 387344003784 putative metal binding site [ion binding]; other site 387344003785 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 387344003786 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 387344003787 S-adenosylmethionine binding site [chemical binding]; other site 387344003788 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 387344003789 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 387344003790 putative acyl-acceptor binding pocket; other site 387344003791 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 387344003792 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 387344003793 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 387344003794 Walker A/P-loop; other site 387344003795 ATP binding site [chemical binding]; other site 387344003796 Q-loop/lid; other site 387344003797 ABC transporter signature motif; other site 387344003798 Walker B; other site 387344003799 D-loop; other site 387344003800 H-loop/switch region; other site 387344003801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 387344003802 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 387344003803 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 387344003804 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 387344003805 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 387344003806 dimer interface [polypeptide binding]; other site 387344003807 active site 387344003808 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 387344003809 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 387344003810 catalytic core [active] 387344003811 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 387344003812 PspC domain; Region: PspC; pfam04024 387344003813 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 387344003814 active site 387344003815 multimer interface [polypeptide binding]; other site 387344003816 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 387344003817 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 387344003818 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 387344003819 CsbD-like; Region: CsbD; pfam05532 387344003820 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 387344003821 Ligand Binding Site [chemical binding]; other site 387344003822 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 387344003823 active site 387344003824 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 387344003825 DHH family; Region: DHH; pfam01368 387344003826 DHHA1 domain; Region: DHHA1; pfam02272 387344003827 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 387344003828 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 387344003829 ribonuclease Z; Region: RNase_Z; TIGR02651 387344003830 GTPase CgtA; Reviewed; Region: obgE; PRK12297 387344003831 GTP1/OBG; Region: GTP1_OBG; pfam01018 387344003832 Obg GTPase; Region: Obg; cd01898 387344003833 G1 box; other site 387344003834 GTP/Mg2+ binding site [chemical binding]; other site 387344003835 Switch I region; other site 387344003836 G2 box; other site 387344003837 G3 box; other site 387344003838 Switch II region; other site 387344003839 G4 box; other site 387344003840 G5 box; other site 387344003841 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 387344003842 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 387344003843 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 387344003844 GIY-YIG motif/motif A; other site 387344003845 active site 387344003846 catalytic site [active] 387344003847 putative DNA binding site [nucleotide binding]; other site 387344003848 metal binding site [ion binding]; metal-binding site 387344003849 UvrB/uvrC motif; Region: UVR; pfam02151 387344003850 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 387344003851 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 387344003852 DNA binding site [nucleotide binding] 387344003853 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 387344003854 putative metal binding site [ion binding]; other site 387344003855 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 387344003856 G1 box; other site 387344003857 GTP/Mg2+ binding site [chemical binding]; other site 387344003858 Switch I region; other site 387344003859 G2 box; other site 387344003860 G3 box; other site 387344003861 Switch II region; other site 387344003862 G4 box; other site 387344003863 G5 box; other site 387344003864 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 387344003865 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 387344003866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 387344003867 Walker A motif; other site 387344003868 ATP binding site [chemical binding]; other site 387344003869 Walker B motif; other site 387344003870 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 387344003871 trigger factor; Provisional; Region: tig; PRK01490 387344003872 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 387344003873 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 387344003874 elongation factor Tu; Reviewed; Region: PRK12736 387344003875 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 387344003876 G1 box; other site 387344003877 GEF interaction site [polypeptide binding]; other site 387344003878 GTP/Mg2+ binding site [chemical binding]; other site 387344003879 Switch I region; other site 387344003880 G2 box; other site 387344003881 G3 box; other site 387344003882 Switch II region; other site 387344003883 G4 box; other site 387344003884 G5 box; other site 387344003885 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 387344003886 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 387344003887 Antibiotic Binding Site [chemical binding]; other site 387344003888 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 387344003889 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 387344003890 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 387344003891 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 387344003892 16S/18S rRNA binding site [nucleotide binding]; other site 387344003893 S13e-L30e interaction site [polypeptide binding]; other site 387344003894 25S rRNA binding site [nucleotide binding]; other site 387344003895 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 387344003896 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 387344003897 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 387344003898 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 387344003899 Competence protein; Region: Competence; pfam03772 387344003900 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 387344003901 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 387344003902 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 387344003903 catalytic motif [active] 387344003904 Zn binding site [ion binding]; other site 387344003905 SLBB domain; Region: SLBB; pfam10531 387344003906 comEA protein; Region: comE; TIGR01259 387344003907 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 387344003908 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 387344003909 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 387344003910 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 387344003911 active site 387344003912 (T/H)XGH motif; other site 387344003913 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 387344003914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 387344003915 S-adenosylmethionine binding site [chemical binding]; other site 387344003916 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 387344003917 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 387344003918 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 387344003919 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 387344003920 putative GEF interaction site [polypeptide binding]; other site 387344003921 G1 box; other site 387344003922 GTP/Mg2+ binding site [chemical binding]; other site 387344003923 Switch I region; other site 387344003924 G2 box; other site 387344003925 G3 box; other site 387344003926 Switch II region; other site 387344003927 G4 box; other site 387344003928 G5 box; other site 387344003929 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 387344003930 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 387344003931 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 387344003932 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 387344003933 active site 387344003934 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 387344003935 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 387344003936 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 387344003937 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 387344003938 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 387344003939 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 387344003940 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 387344003941 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 387344003942 E3 interaction surface; other site 387344003943 lipoyl attachment site [posttranslational modification]; other site 387344003944 e3 binding domain; Region: E3_binding; pfam02817 387344003945 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 387344003946 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 387344003947 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 387344003948 alpha subunit interface [polypeptide binding]; other site 387344003949 TPP binding site [chemical binding]; other site 387344003950 heterodimer interface [polypeptide binding]; other site 387344003951 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 387344003952 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 387344003953 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 387344003954 TPP-binding site [chemical binding]; other site 387344003955 tetramer interface [polypeptide binding]; other site 387344003956 heterodimer interface [polypeptide binding]; other site 387344003957 phosphorylation loop region [posttranslational modification] 387344003958 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 387344003959 active site 387344003960 catalytic residues [active] 387344003961 metal binding site [ion binding]; metal-binding site 387344003962 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 387344003963 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 387344003964 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 387344003965 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 387344003966 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 387344003967 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 387344003968 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 387344003969 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 387344003970 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 387344003971 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 387344003972 NlpC/P60 family; Region: NLPC_P60; pfam00877 387344003973 Predicted secreted protein [Function unknown]; Region: COG4086 387344003974 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 387344003975 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 387344003976 NlpC/P60 family; Region: NLPC_P60; pfam00877 387344003977 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 387344003978 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 387344003979 TPP-binding site [chemical binding]; other site 387344003980 dimer interface [polypeptide binding]; other site 387344003981 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 387344003982 PYR/PP interface [polypeptide binding]; other site 387344003983 dimer interface [polypeptide binding]; other site 387344003984 TPP binding site [chemical binding]; other site 387344003985 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 387344003986 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 387344003987 substrate binding site [chemical binding]; other site 387344003988 dimer interface [polypeptide binding]; other site 387344003989 ATP binding site [chemical binding]; other site 387344003990 Transcriptional regulators [Transcription]; Region: PurR; COG1609 387344003991 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 387344003992 DNA binding site [nucleotide binding] 387344003993 domain linker motif; other site 387344003994 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 387344003995 dimerization interface [polypeptide binding]; other site 387344003996 ligand binding site [chemical binding]; other site 387344003997 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 387344003998 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 387344003999 active site 387344004000 catalytic tetrad [active] 387344004001 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 387344004002 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 387344004003 putative active site [active] 387344004004 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 387344004005 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 387344004006 peptide binding site [polypeptide binding]; other site 387344004007 amidase; Provisional; Region: PRK06529 387344004008 Amidase; Region: Amidase; cl11426 387344004009 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 387344004010 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 387344004011 substrate binding pocket [chemical binding]; other site 387344004012 membrane-bound complex binding site; other site 387344004013 hinge residues; other site 387344004014 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 387344004015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 387344004016 dimer interface [polypeptide binding]; other site 387344004017 conserved gate region; other site 387344004018 putative PBP binding loops; other site 387344004019 ABC-ATPase subunit interface; other site 387344004020 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 387344004021 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 387344004022 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 387344004023 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 387344004024 active site 387344004025 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 387344004026 AAA domain; Region: AAA_30; pfam13604 387344004027 Family description; Region: UvrD_C_2; pfam13538 387344004028 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 387344004029 binding surface 387344004030 TPR motif; other site 387344004031 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 387344004032 binding surface 387344004033 TPR motif; other site 387344004034 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 387344004035 catalytic core [active] 387344004036 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 387344004037 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 387344004038 Putative amino acid metabolism; Region: DUF1831; pfam08866 387344004039 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 387344004040 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 387344004041 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 387344004042 catalytic residue [active] 387344004043 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 387344004044 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 387344004045 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 387344004046 dimer interface [polypeptide binding]; other site 387344004047 ADP-ribose binding site [chemical binding]; other site 387344004048 active site 387344004049 nudix motif; other site 387344004050 metal binding site [ion binding]; metal-binding site 387344004051 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 387344004052 DNA-binding site [nucleotide binding]; DNA binding site 387344004053 RNA-binding motif; other site 387344004054 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 387344004055 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 387344004056 active site 387344004057 HIGH motif; other site 387344004058 nucleotide binding site [chemical binding]; other site 387344004059 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 387344004060 active site 387344004061 KMSKS motif; other site 387344004062 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 387344004063 tRNA binding surface [nucleotide binding]; other site 387344004064 anticodon binding site; other site 387344004065 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 387344004066 DivIVA protein; Region: DivIVA; pfam05103 387344004067 DivIVA domain; Region: DivI1A_domain; TIGR03544 387344004068 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 387344004069 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 387344004070 RNA binding surface [nucleotide binding]; other site 387344004071 YGGT family; Region: YGGT; pfam02325 387344004072 Protein of unknown function (DUF552); Region: DUF552; pfam04472 387344004073 cell division protein FtsZ; Validated; Region: PRK09330 387344004074 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 387344004075 nucleotide binding site [chemical binding]; other site 387344004076 SulA interaction site; other site 387344004077 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 387344004078 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 387344004079 nucleotide binding site [chemical binding]; other site 387344004080 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 387344004081 Cell division protein FtsA; Region: FtsA; pfam14450 387344004082 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 387344004083 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 387344004084 Cell division protein FtsQ; Region: FtsQ; pfam03799 387344004085 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 387344004086 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 387344004087 active site 387344004088 homodimer interface [polypeptide binding]; other site 387344004089 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 387344004090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 387344004091 S-adenosylmethionine binding site [chemical binding]; other site 387344004092 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 387344004093 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 387344004094 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 387344004095 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 387344004096 Mg++ binding site [ion binding]; other site 387344004097 putative catalytic motif [active] 387344004098 putative substrate binding site [chemical binding]; other site 387344004099 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 387344004100 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 387344004101 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 387344004102 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 387344004103 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 387344004104 Cell division protein FtsL; Region: FtsL; cl11433 387344004105 MraW methylase family; Region: Methyltransf_5; pfam01795 387344004106 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 387344004107 cell division protein MraZ; Reviewed; Region: PRK00326 387344004108 MraZ protein; Region: MraZ; pfam02381 387344004109 MraZ protein; Region: MraZ; pfam02381 387344004110 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 387344004111 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 387344004112 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 387344004113 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 387344004114 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 387344004115 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 387344004116 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 387344004117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 387344004118 S-adenosylmethionine binding site [chemical binding]; other site 387344004119 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 387344004120 Domain of unknown function DUF20; Region: UPF0118; pfam01594 387344004121 CutC family; Region: CutC; cl01218 387344004122 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 387344004123 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 387344004124 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 387344004125 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 387344004126 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 387344004127 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 387344004128 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 387344004129 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 387344004130 active site 387344004131 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 387344004132 ATP-NAD kinase; Region: NAD_kinase; pfam01513 387344004133 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 387344004134 synthetase active site [active] 387344004135 NTP binding site [chemical binding]; other site 387344004136 metal binding site [ion binding]; metal-binding site 387344004137 Thioredoxin; Region: Thioredoxin_5; pfam13743 387344004138 EDD domain protein, DegV family; Region: DegV; TIGR00762 387344004139 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 387344004140 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 387344004141 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 387344004142 active site 387344004143 Zn binding site [ion binding]; other site 387344004144 Competence protein CoiA-like family; Region: CoiA; cl11541 387344004145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 387344004146 S-adenosylmethionine binding site [chemical binding]; other site 387344004147 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 387344004148 Phosphotransferase enzyme family; Region: APH; pfam01636 387344004149 active site 387344004150 substrate binding site [chemical binding]; other site 387344004151 ATP binding site [chemical binding]; other site 387344004152 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 387344004153 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 387344004154 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 387344004155 Walker A/P-loop; other site 387344004156 ATP binding site [chemical binding]; other site 387344004157 Q-loop/lid; other site 387344004158 ABC transporter signature motif; other site 387344004159 Walker B; other site 387344004160 D-loop; other site 387344004161 H-loop/switch region; other site 387344004162 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 387344004163 HIT family signature motif; other site 387344004164 catalytic residue [active] 387344004165 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 387344004166 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 387344004167 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 387344004168 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 387344004169 generic binding surface II; other site 387344004170 generic binding surface I; other site 387344004171 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 387344004172 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 387344004173 Zn2+ binding site [ion binding]; other site 387344004174 Mg2+ binding site [ion binding]; other site 387344004175 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 387344004176 Walker A/P-loop; other site 387344004177 ATP binding site [chemical binding]; other site 387344004178 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 387344004179 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 387344004180 active site 387344004181 metal binding site [ion binding]; metal-binding site 387344004182 DNA binding site [nucleotide binding] 387344004183 Protein of unknown function (DUF964); Region: DUF964; cl01483 387344004184 Transglycosylase; Region: Transgly; pfam00912 387344004185 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 387344004186 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 387344004187 Arginine repressor [Transcription]; Region: ArgR; COG1438 387344004188 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 387344004189 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 387344004190 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 387344004191 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 387344004192 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 387344004193 active site 387344004194 HIGH motif; other site 387344004195 KMSK motif region; other site 387344004196 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 387344004197 tRNA binding surface [nucleotide binding]; other site 387344004198 anticodon binding site; other site 387344004199 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 387344004200 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 387344004201 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 387344004202 DNA helicase, putative; Region: TIGR00376 387344004203 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 387344004204 amidase catalytic site [active] 387344004205 Zn binding residues [ion binding]; other site 387344004206 substrate binding site [chemical binding]; other site 387344004207 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 387344004208 RibD C-terminal domain; Region: RibD_C; cl17279 387344004209 Protein of unknown function (DUF1516); Region: DUF1516; pfam07457 387344004210 aspartate racemase; Region: asp_race; TIGR00035 387344004211 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 387344004212 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 387344004213 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 387344004214 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 387344004215 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 387344004216 active site 387344004217 dimer interface [polypeptide binding]; other site 387344004218 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 387344004219 Ligand Binding Site [chemical binding]; other site 387344004220 Molecular Tunnel; other site 387344004221 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 387344004222 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 387344004223 ligand binding site [chemical binding]; other site 387344004224 flexible hinge region; other site 387344004225 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 387344004226 putative switch regulator; other site 387344004227 non-specific DNA interactions [nucleotide binding]; other site 387344004228 DNA binding site [nucleotide binding] 387344004229 sequence specific DNA binding site [nucleotide binding]; other site 387344004230 putative cAMP binding site [chemical binding]; other site 387344004231 Peptidase family C69; Region: Peptidase_C69; pfam03577 387344004232 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 387344004233 Walker A/P-loop; other site 387344004234 ATP binding site [chemical binding]; other site 387344004235 Q-loop/lid; other site 387344004236 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 387344004237 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 387344004238 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 387344004239 ABC transporter signature motif; other site 387344004240 Walker B; other site 387344004241 D-loop; other site 387344004242 H-loop/switch region; other site 387344004243 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 387344004244 Walker A/P-loop; other site 387344004245 ATP binding site [chemical binding]; other site 387344004246 Q-loop/lid; other site 387344004247 ABC transporter signature motif; other site 387344004248 Walker B; other site 387344004249 D-loop; other site 387344004250 H-loop/switch region; other site 387344004251 Helix-turn-helix domain; Region: HTH_28; pfam13518 387344004252 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 387344004253 Transposase; Region: HTH_Tnp_1; cl17663 387344004254 Integrase core domain; Region: rve; pfam00665 387344004255 Integrase core domain; Region: rve_2; pfam13333 387344004256 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 387344004257 VanZ like family; Region: VanZ; cl01971 387344004258 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 387344004259 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 387344004260 putative DNA binding site [nucleotide binding]; other site 387344004261 putative Zn2+ binding site [ion binding]; other site 387344004262 MarR family; Region: MarR_2; cl17246 387344004263 CAAX protease self-immunity; Region: Abi; pfam02517 387344004264 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 387344004265 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 387344004266 putative ligand binding site [chemical binding]; other site 387344004267 putative NAD binding site [chemical binding]; other site 387344004268 catalytic site [active] 387344004269 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 387344004270 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 387344004271 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 387344004272 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 387344004273 beta-phosphoglucomutase; Region: bPGM; TIGR01990 387344004274 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 387344004275 motif II; other site 387344004276 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 387344004277 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 387344004278 active site 387344004279 motif I; other site 387344004280 motif II; other site 387344004281 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 387344004282 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 387344004283 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 387344004284 Substrate-binding site [chemical binding]; other site 387344004285 Substrate specificity [chemical binding]; other site 387344004286 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 387344004287 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 387344004288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344004289 putative substrate translocation pore; other site 387344004290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344004291 S-adenosylmethionine synthetase; Validated; Region: PRK05250 387344004292 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 387344004293 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 387344004294 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 387344004295 hypothetical protein; Provisional; Region: PRK00967 387344004296 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 387344004297 active site 387344004298 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 387344004299 Ligand Binding Site [chemical binding]; other site 387344004300 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 387344004301 Sulfatase; Region: Sulfatase; pfam00884 387344004302 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 387344004303 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 387344004304 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 387344004305 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 387344004306 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 387344004307 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 387344004308 putative ADP-binding pocket [chemical binding]; other site 387344004309 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 387344004310 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 387344004311 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 387344004312 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 387344004313 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 387344004314 dimerization domain swap beta strand [polypeptide binding]; other site 387344004315 regulatory protein interface [polypeptide binding]; other site 387344004316 active site 387344004317 regulatory phosphorylation site [posttranslational modification]; other site 387344004318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 387344004319 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 387344004320 Walker A motif; other site 387344004321 ATP binding site [chemical binding]; other site 387344004322 Walker B motif; other site 387344004323 arginine finger; other site 387344004324 endopeptidase Clp ATP-binding regulatory subunit (clpX); Region: clpX; TIGR00382 387344004325 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 387344004326 Walker A motif; other site 387344004327 ATP binding site [chemical binding]; other site 387344004328 Walker B motif; other site 387344004329 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 387344004330 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 387344004331 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 387344004332 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 387344004333 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 387344004334 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 387344004335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 387344004336 motif II; other site 387344004337 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 387344004338 Peptidase family C69; Region: Peptidase_C69; pfam03577 387344004339 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 387344004340 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 387344004341 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 387344004342 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 387344004343 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 387344004344 legume lectins; Region: lectin_L-type; cd01951 387344004345 homotetramer interaction site [polypeptide binding]; other site 387344004346 carbohydrate binding site [chemical binding]; other site 387344004347 metal binding site [ion binding]; metal-binding site 387344004348 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 387344004349 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 387344004350 G1 box; other site 387344004351 putative GEF interaction site [polypeptide binding]; other site 387344004352 GTP/Mg2+ binding site [chemical binding]; other site 387344004353 Switch I region; other site 387344004354 G2 box; other site 387344004355 G3 box; other site 387344004356 Switch II region; other site 387344004357 G4 box; other site 387344004358 G5 box; other site 387344004359 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 387344004360 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 387344004361 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 387344004362 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 387344004363 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 387344004364 active site 387344004365 nucleotide binding site [chemical binding]; other site 387344004366 HIGH motif; other site 387344004367 KMSKS motif; other site 387344004368 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 387344004369 Domain of unknown function DUF20; Region: UPF0118; pfam01594 387344004370 hypothetical protein; Provisional; Region: PRK13662 387344004371 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 387344004372 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 387344004373 Beta-lactamase; Region: Beta-lactamase; pfam00144 387344004374 recombination regulator RecX; Provisional; Region: recX; PRK14135 387344004375 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 387344004376 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 387344004377 Nuclease-related domain; Region: NERD; pfam08378 387344004378 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 387344004379 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 387344004380 active site 387344004381 homodimer interface [polypeptide binding]; other site 387344004382 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 387344004383 Putative Catalytic site; other site 387344004384 DXD motif; other site 387344004385 GntP family permease; Region: GntP_permease; pfam02447 387344004386 fructuronate transporter; Provisional; Region: PRK10034; cl15264 387344004387 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 387344004388 Ligand Binding Site [chemical binding]; other site 387344004389 DEAD-like helicases superfamily; Region: DEXDc; smart00487 387344004390 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 387344004391 ATP binding site [chemical binding]; other site 387344004392 putative Mg++ binding site [ion binding]; other site 387344004393 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 387344004394 nucleotide binding region [chemical binding]; other site 387344004395 ATP-binding site [chemical binding]; other site 387344004396 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 387344004397 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 387344004398 EIAV coat protein, gp90; Region: EIAV_GP90; pfam00971 387344004399 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419 387344004400 active site 387344004401 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 387344004402 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 387344004403 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 387344004404 putative active site [active] 387344004405 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 387344004406 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 387344004407 N- and C-terminal domain interface [polypeptide binding]; other site 387344004408 active site 387344004409 catalytic site [active] 387344004410 metal binding site [ion binding]; metal-binding site 387344004411 carbohydrate binding site [chemical binding]; other site 387344004412 ATP binding site [chemical binding]; other site 387344004413 GntP family permease; Region: GntP_permease; pfam02447 387344004414 fructuronate transporter; Provisional; Region: PRK10034; cl15264 387344004415 Amino acid permease; Region: AA_permease_2; pfam13520 387344004416 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 387344004417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344004418 putative substrate translocation pore; other site 387344004419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344004420 D-ribose pyranase; Provisional; Region: PRK11797 387344004421 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 387344004422 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 387344004423 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 387344004424 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 387344004425 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 387344004426 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 387344004427 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 387344004428 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 387344004429 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 387344004430 phosphopentomutase; Provisional; Region: PRK05362 387344004431 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 387344004432 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 387344004433 intersubunit interface [polypeptide binding]; other site 387344004434 active site 387344004435 catalytic residue [active] 387344004436 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 387344004437 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 387344004438 non-specific DNA binding site [nucleotide binding]; other site 387344004439 salt bridge; other site 387344004440 sequence-specific DNA binding site [nucleotide binding]; other site 387344004441 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 387344004442 sequence-specific DNA binding site [nucleotide binding]; other site 387344004443 salt bridge; other site 387344004444 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 387344004445 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 387344004446 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 387344004447 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 387344004448 putative active site [active] 387344004449 putative FMN binding site [chemical binding]; other site 387344004450 putative substrate binding site [chemical binding]; other site 387344004451 putative catalytic residue [active] 387344004452 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 387344004453 putative hexamer interface [polypeptide binding]; other site 387344004454 putative hexagonal pore; other site 387344004455 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 387344004456 propionate/acetate kinase; Provisional; Region: PRK12379 387344004457 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 387344004458 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 387344004459 putative active site [active] 387344004460 metal binding site [ion binding]; metal-binding site 387344004461 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 387344004462 putative catalytic cysteine [active] 387344004463 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 387344004464 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 387344004465 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 387344004466 Hexamer/Pentamer interface [polypeptide binding]; other site 387344004467 central pore; other site 387344004468 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 387344004469 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 387344004470 Propanediol utilisation protein PduL; Region: PduL; pfam06130 387344004471 Propanediol utilisation protein PduL; Region: PduL; pfam06130 387344004472 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 387344004473 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 387344004474 Hexamer interface [polypeptide binding]; other site 387344004475 Hexagonal pore residue; other site 387344004476 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 387344004477 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 387344004478 putative hexamer interface [polypeptide binding]; other site 387344004479 putative hexagonal pore; other site 387344004480 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 387344004481 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 387344004482 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 387344004483 Dehydratase small subunit; Region: Dehydratase_SU; pfam02287 387344004484 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 387344004485 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 387344004486 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 387344004487 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 387344004488 alpha-beta subunit interface [polypeptide binding]; other site 387344004489 alpha-gamma subunit interface [polypeptide binding]; other site 387344004490 active site 387344004491 substrate and K+ binding site; other site 387344004492 K+ binding site [ion binding]; other site 387344004493 cobalamin binding site [chemical binding]; other site 387344004494 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 387344004495 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutL; COG4816 387344004496 putative hexamer interface [polypeptide binding]; other site 387344004497 putative hexagonal pore; other site 387344004498 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 387344004499 putative hexamer interface [polypeptide binding]; other site 387344004500 putative hexagonal pore; other site 387344004501 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 387344004502 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 387344004503 Hexamer interface [polypeptide binding]; other site 387344004504 Putative hexagonal pore residue; other site 387344004505 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 387344004506 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 387344004507 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 387344004508 amphipathic channel; other site 387344004509 Asn-Pro-Ala signature motifs; other site 387344004510 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 387344004511 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 387344004512 DNA methylase; Region: N6_N4_Mtase; cl17433 387344004513 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 387344004514 Helix-turn-helix domain; Region: HTH_38; pfam13936 387344004515 Integrase core domain; Region: rve; pfam00665 387344004516 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 387344004517 DNA methylase; Region: N6_N4_Mtase; cl17433 387344004518 DNA methylase; Region: N6_N4_Mtase; pfam01555 387344004519 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 387344004520 TRAM domain; Region: TRAM; pfam01938 387344004521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 387344004522 S-adenosylmethionine binding site [chemical binding]; other site 387344004523 putative lipid kinase; Reviewed; Region: PRK13055 387344004524 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 387344004525 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 387344004526 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 387344004527 GatB domain; Region: GatB_Yqey; smart00845 387344004528 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 387344004529 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 387344004530 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 387344004531 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 387344004532 putative dimer interface [polypeptide binding]; other site 387344004533 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 387344004534 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 387344004535 putative dimer interface [polypeptide binding]; other site 387344004536 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 387344004537 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 387344004538 nucleotide binding pocket [chemical binding]; other site 387344004539 K-X-D-G motif; other site 387344004540 catalytic site [active] 387344004541 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 387344004542 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 387344004543 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 387344004544 Dimer interface [polypeptide binding]; other site 387344004545 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 387344004546 Part of AAA domain; Region: AAA_19; pfam13245 387344004547 Family description; Region: UvrD_C_2; pfam13538 387344004548 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 387344004549 ATP-grasp domain; Region: ATP-grasp_4; cl17255 387344004550 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 387344004551 active site 387344004552 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 387344004553 UbiA prenyltransferase family; Region: UbiA; pfam01040 387344004554 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 387344004555 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 387344004556 substrate binding pocket [chemical binding]; other site 387344004557 chain length determination region; other site 387344004558 substrate-Mg2+ binding site; other site 387344004559 catalytic residues [active] 387344004560 aspartate-rich region 1; other site 387344004561 active site lid residues [active] 387344004562 aspartate-rich region 2; other site 387344004563 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 387344004564 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 387344004565 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 387344004566 Walker A/P-loop; other site 387344004567 ATP binding site [chemical binding]; other site 387344004568 Q-loop/lid; other site 387344004569 ABC transporter signature motif; other site 387344004570 Walker B; other site 387344004571 D-loop; other site 387344004572 H-loop/switch region; other site 387344004573 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 387344004574 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 387344004575 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 387344004576 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 387344004577 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 387344004578 putative ligand binding site [chemical binding]; other site 387344004579 NAD binding site [chemical binding]; other site 387344004580 catalytic site [active] 387344004581 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 387344004582 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 387344004583 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 387344004584 Helix-turn-helix domain; Region: HTH_38; pfam13936 387344004585 Integrase core domain; Region: rve; pfam00665 387344004586 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 387344004587 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 387344004588 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 387344004589 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 387344004590 amino acid transporter; Region: 2A0306; TIGR00909 387344004591 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 387344004592 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 387344004593 dimer interface [polypeptide binding]; other site 387344004594 active site 387344004595 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 387344004596 homopentamer interface [polypeptide binding]; other site 387344004597 active site 387344004598 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 387344004599 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 387344004600 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 387344004601 dimerization interface [polypeptide binding]; other site 387344004602 active site 387344004603 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 387344004604 Lumazine binding domain; Region: Lum_binding; pfam00677 387344004605 Lumazine binding domain; Region: Lum_binding; pfam00677 387344004606 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 387344004607 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 387344004608 catalytic motif [active] 387344004609 Zn binding site [ion binding]; other site 387344004610 RibD C-terminal domain; Region: RibD_C; cl17279 387344004611 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 387344004612 TrkA-N domain; Region: TrkA_N; pfam02254 387344004613 TrkA-C domain; Region: TrkA_C; pfam02080 387344004614 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 387344004615 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 387344004616 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 387344004617 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 387344004618 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 387344004619 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 387344004620 23S rRNA interface [nucleotide binding]; other site 387344004621 L3 interface [polypeptide binding]; other site 387344004622 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 387344004623 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 387344004624 dimerization interface 3.5A [polypeptide binding]; other site 387344004625 active site 387344004626 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 387344004627 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 387344004628 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 387344004629 Walker A/P-loop; other site 387344004630 ATP binding site [chemical binding]; other site 387344004631 Q-loop/lid; other site 387344004632 ABC transporter signature motif; other site 387344004633 Walker B; other site 387344004634 D-loop; other site 387344004635 H-loop/switch region; other site 387344004636 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 387344004637 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 387344004638 Walker A/P-loop; other site 387344004639 ATP binding site [chemical binding]; other site 387344004640 Q-loop/lid; other site 387344004641 ABC transporter signature motif; other site 387344004642 Walker B; other site 387344004643 D-loop; other site 387344004644 H-loop/switch region; other site 387344004645 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 387344004646 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 387344004647 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 387344004648 alphaNTD homodimer interface [polypeptide binding]; other site 387344004649 alphaNTD - beta interaction site [polypeptide binding]; other site 387344004650 alphaNTD - beta' interaction site [polypeptide binding]; other site 387344004651 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 387344004652 30S ribosomal protein S11; Validated; Region: PRK05309 387344004653 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 387344004654 30S ribosomal protein S13; Region: bact_S13; TIGR03631 387344004655 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 387344004656 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 387344004657 rRNA binding site [nucleotide binding]; other site 387344004658 predicted 30S ribosome binding site; other site 387344004659 adenylate kinase; Reviewed; Region: adk; PRK00279 387344004660 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 387344004661 AMP-binding site [chemical binding]; other site 387344004662 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 387344004663 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 387344004664 SecY translocase; Region: SecY; pfam00344 387344004665 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 387344004666 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 387344004667 23S rRNA binding site [nucleotide binding]; other site 387344004668 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 387344004669 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 387344004670 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 387344004671 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 387344004672 5S rRNA interface [nucleotide binding]; other site 387344004673 L27 interface [polypeptide binding]; other site 387344004674 23S rRNA interface [nucleotide binding]; other site 387344004675 L5 interface [polypeptide binding]; other site 387344004676 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 387344004677 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 387344004678 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 387344004679 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 387344004680 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 387344004681 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 387344004682 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 387344004683 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 387344004684 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 387344004685 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 387344004686 RNA binding site [nucleotide binding]; other site 387344004687 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 387344004688 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 387344004689 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 387344004690 23S rRNA interface [nucleotide binding]; other site 387344004691 putative translocon interaction site; other site 387344004692 signal recognition particle (SRP54) interaction site; other site 387344004693 L23 interface [polypeptide binding]; other site 387344004694 trigger factor interaction site; other site 387344004695 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 387344004696 23S rRNA interface [nucleotide binding]; other site 387344004697 5S rRNA interface [nucleotide binding]; other site 387344004698 putative antibiotic binding site [chemical binding]; other site 387344004699 L25 interface [polypeptide binding]; other site 387344004700 L27 interface [polypeptide binding]; other site 387344004701 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 387344004702 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 387344004703 G-X-X-G motif; other site 387344004704 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 387344004705 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 387344004706 putative translocon binding site; other site 387344004707 protein-rRNA interface [nucleotide binding]; other site 387344004708 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 387344004709 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 387344004710 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 387344004711 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 387344004712 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 387344004713 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 387344004714 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 387344004715 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 387344004716 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 387344004717 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 387344004718 elongation factor G; Reviewed; Region: PRK12739 387344004719 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 387344004720 G1 box; other site 387344004721 putative GEF interaction site [polypeptide binding]; other site 387344004722 GTP/Mg2+ binding site [chemical binding]; other site 387344004723 Switch I region; other site 387344004724 G2 box; other site 387344004725 G3 box; other site 387344004726 Switch II region; other site 387344004727 G4 box; other site 387344004728 G5 box; other site 387344004729 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 387344004730 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 387344004731 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 387344004732 30S ribosomal protein S7; Validated; Region: PRK05302 387344004733 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 387344004734 S17 interaction site [polypeptide binding]; other site 387344004735 S8 interaction site; other site 387344004736 16S rRNA interaction site [nucleotide binding]; other site 387344004737 streptomycin interaction site [chemical binding]; other site 387344004738 23S rRNA interaction site [nucleotide binding]; other site 387344004739 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 387344004740 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 387344004741 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 387344004742 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 387344004743 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 387344004744 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 387344004745 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 387344004746 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 387344004747 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 387344004748 cleft; other site 387344004749 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 387344004750 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 387344004751 DNA binding site [nucleotide binding] 387344004752 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 387344004753 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 387344004754 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 387344004755 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 387344004756 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 387344004757 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 387344004758 RPB1 interaction site [polypeptide binding]; other site 387344004759 RPB10 interaction site [polypeptide binding]; other site 387344004760 RPB11 interaction site [polypeptide binding]; other site 387344004761 RPB3 interaction site [polypeptide binding]; other site 387344004762 RPB12 interaction site [polypeptide binding]; other site 387344004763 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 387344004764 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 387344004765 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 387344004766 Clp amino terminal domain; Region: Clp_N; pfam02861 387344004767 Clp amino terminal domain; Region: Clp_N; pfam02861 387344004768 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 387344004769 Walker A motif; other site 387344004770 ATP binding site [chemical binding]; other site 387344004771 Walker B motif; other site 387344004772 arginine finger; other site 387344004773 UvrB/uvrC motif; Region: UVR; pfam02151 387344004774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 387344004775 Walker A motif; other site 387344004776 ATP binding site [chemical binding]; other site 387344004777 Walker B motif; other site 387344004778 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 387344004779 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 387344004780 seryl-tRNA synthetase; Provisional; Region: PRK05431 387344004781 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 387344004782 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 387344004783 dimer interface [polypeptide binding]; other site 387344004784 active site 387344004785 motif 1; other site 387344004786 motif 2; other site 387344004787 motif 3; other site 387344004788 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 387344004789 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 387344004790 Substrate-binding site [chemical binding]; other site 387344004791 Substrate specificity [chemical binding]; other site 387344004792 lysine transporter; Provisional; Region: PRK10836 387344004793 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 387344004794 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 387344004795 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 387344004796 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 387344004797 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 387344004798 active site 387344004799 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 387344004800 Uncharacterized conserved protein [Function unknown]; Region: COG2966 387344004801 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 387344004802 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 387344004803 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 387344004804 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 387344004805 FeoA domain; Region: FeoA; pfam04023 387344004806 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 387344004807 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 387344004808 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 387344004809 Coenzyme A binding pocket [chemical binding]; other site 387344004810 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 387344004811 Helix-turn-helix domain; Region: HTH_38; pfam13936 387344004812 Homeodomain-like domain; Region: HTH_32; pfam13565 387344004813 Integrase core domain; Region: rve; pfam00665 387344004814 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 387344004815 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 387344004816 DNA binding residues [nucleotide binding] 387344004817 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 387344004818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344004819 putative substrate translocation pore; other site 387344004820 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 387344004821 DNA binding residues [nucleotide binding] 387344004822 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 387344004823 putative dimer interface [polypeptide binding]; other site 387344004824 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 387344004825 Helix-turn-helix domain; Region: HTH_38; pfam13936 387344004826 Homeodomain-like domain; Region: HTH_32; pfam13565 387344004827 Integrase core domain; Region: rve; pfam00665 387344004828 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 387344004829 Predicted membrane protein [Function unknown]; Region: COG4392 387344004830 uracil transporter; Provisional; Region: PRK10720 387344004831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344004832 H+ Antiporter protein; Region: 2A0121; TIGR00900 387344004833 putative substrate translocation pore; other site 387344004834 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 387344004835 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 387344004836 Coenzyme A binding pocket [chemical binding]; other site 387344004837 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 387344004838 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 387344004839 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 387344004840 Coenzyme A binding pocket [chemical binding]; other site 387344004841 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 387344004842 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 387344004843 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 387344004844 active site 387344004845 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 387344004846 lipoyl-biotinyl attachment site [posttranslational modification]; other site 387344004847 maltose O-acetyltransferase; Provisional; Region: PRK10092 387344004848 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 387344004849 active site 387344004850 substrate binding site [chemical binding]; other site 387344004851 trimer interface [polypeptide binding]; other site 387344004852 CoA binding site [chemical binding]; other site 387344004853 L-arabinose isomerase; Provisional; Region: PRK02929 387344004854 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 387344004855 hexamer (dimer of trimers) interface [polypeptide binding]; other site 387344004856 substrate binding site [chemical binding]; other site 387344004857 trimer interface [polypeptide binding]; other site 387344004858 Mn binding site [ion binding]; other site 387344004859 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 387344004860 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 387344004861 intersubunit interface [polypeptide binding]; other site 387344004862 active site 387344004863 Zn2+ binding site [ion binding]; other site 387344004864 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 387344004865 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 387344004866 putative N- and C-terminal domain interface [polypeptide binding]; other site 387344004867 putative active site [active] 387344004868 MgATP binding site [chemical binding]; other site 387344004869 catalytic site [active] 387344004870 metal binding site [ion binding]; metal-binding site 387344004871 putative carbohydrate binding site [chemical binding]; other site 387344004872 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 387344004873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344004874 putative substrate translocation pore; other site 387344004875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344004876 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 387344004877 DNA-binding site [nucleotide binding]; DNA binding site 387344004878 Transcriptional regulators [Transcription]; Region: PurR; COG1609 387344004879 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 387344004880 putative dimerization interface [polypeptide binding]; other site 387344004881 putative ligand binding site [chemical binding]; other site 387344004882 maltose O-acetyltransferase; Provisional; Region: PRK10092 387344004883 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 387344004884 active site 387344004885 substrate binding site [chemical binding]; other site 387344004886 trimer interface [polypeptide binding]; other site 387344004887 CoA binding site [chemical binding]; other site 387344004888 Predicted transcriptional regulator [Transcription]; Region: COG4189 387344004889 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 387344004890 putative DNA binding site [nucleotide binding]; other site 387344004891 dimerization interface [polypeptide binding]; other site 387344004892 putative Zn2+ binding site [ion binding]; other site 387344004893 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 387344004894 Helix-turn-helix domain; Region: HTH_38; pfam13936 387344004895 Integrase core domain; Region: rve; pfam00665 387344004896 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 387344004897 active site 387344004898 galactoside permease; Reviewed; Region: lacY; PRK09528 387344004899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344004900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344004901 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 387344004902 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 387344004903 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 387344004904 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 387344004905 ATP binding site [chemical binding]; other site 387344004906 putative Mg++ binding site [ion binding]; other site 387344004907 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 387344004908 nucleotide binding region [chemical binding]; other site 387344004909 ATP-binding site [chemical binding]; other site 387344004910 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 387344004911 HRDC domain; Region: HRDC; pfam00570 387344004912 Transcriptional regulator; Region: Rrf2; pfam02082 387344004913 Rrf2 family protein; Region: rrf2_super; TIGR00738 387344004914 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 387344004915 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 387344004916 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 387344004917 Peptidase family C69; Region: Peptidase_C69; pfam03577 387344004918 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 387344004919 Peptidase family M1; Region: Peptidase_M1; pfam01433 387344004920 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 387344004921 Zn binding site [ion binding]; other site 387344004922 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 387344004923 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 387344004924 Melibiase; Region: Melibiase; pfam02065 387344004925 GMP synthase; Reviewed; Region: guaA; PRK00074 387344004926 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 387344004927 AMP/PPi binding site [chemical binding]; other site 387344004928 candidate oxyanion hole; other site 387344004929 catalytic triad [active] 387344004930 potential glutamine specificity residues [chemical binding]; other site 387344004931 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 387344004932 ATP Binding subdomain [chemical binding]; other site 387344004933 Dimerization subdomain; other site 387344004934 pantothenate kinase; Provisional; Region: PRK05439 387344004935 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 387344004936 ATP-binding site [chemical binding]; other site 387344004937 CoA-binding site [chemical binding]; other site 387344004938 Mg2+-binding site [ion binding]; other site 387344004939 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 387344004940 Part of AAA domain; Region: AAA_19; pfam13245 387344004941 Family description; Region: UvrD_C_2; pfam13538 387344004942 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 387344004943 catalytic core [active] 387344004944 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 387344004945 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 387344004946 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 387344004947 Walker A/P-loop; other site 387344004948 ATP binding site [chemical binding]; other site 387344004949 Q-loop/lid; other site 387344004950 ABC transporter signature motif; other site 387344004951 Walker B; other site 387344004952 D-loop; other site 387344004953 H-loop/switch region; other site 387344004954 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 387344004955 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 387344004956 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 387344004957 Walker A/P-loop; other site 387344004958 ATP binding site [chemical binding]; other site 387344004959 Q-loop/lid; other site 387344004960 ABC transporter signature motif; other site 387344004961 Walker B; other site 387344004962 D-loop; other site 387344004963 H-loop/switch region; other site 387344004964 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 387344004965 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 387344004966 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 387344004967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 387344004968 dimer interface [polypeptide binding]; other site 387344004969 conserved gate region; other site 387344004970 putative PBP binding loops; other site 387344004971 ABC-ATPase subunit interface; other site 387344004972 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 387344004973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 387344004974 dimer interface [polypeptide binding]; other site 387344004975 conserved gate region; other site 387344004976 putative PBP binding loops; other site 387344004977 ABC-ATPase subunit interface; other site 387344004978 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 387344004979 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 387344004980 peptide binding site [polypeptide binding]; other site 387344004981 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 387344004982 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 387344004983 peptide binding site [polypeptide binding]; other site 387344004984 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 387344004985 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 387344004986 HflX GTPase family; Region: HflX; cd01878 387344004987 G1 box; other site 387344004988 GTP/Mg2+ binding site [chemical binding]; other site 387344004989 Switch I region; other site 387344004990 G2 box; other site 387344004991 G3 box; other site 387344004992 Switch II region; other site 387344004993 G4 box; other site 387344004994 G5 box; other site 387344004995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 387344004996 dimer interface [polypeptide binding]; other site 387344004997 conserved gate region; other site 387344004998 putative PBP binding loops; other site 387344004999 ABC-ATPase subunit interface; other site 387344005000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 387344005001 dimer interface [polypeptide binding]; other site 387344005002 conserved gate region; other site 387344005003 putative PBP binding loops; other site 387344005004 ABC-ATPase subunit interface; other site 387344005005 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 387344005006 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 387344005007 substrate binding pocket [chemical binding]; other site 387344005008 membrane-bound complex binding site; other site 387344005009 hinge residues; other site 387344005010 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 387344005011 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 387344005012 Walker A/P-loop; other site 387344005013 ATP binding site [chemical binding]; other site 387344005014 Q-loop/lid; other site 387344005015 ABC transporter signature motif; other site 387344005016 Walker B; other site 387344005017 D-loop; other site 387344005018 H-loop/switch region; other site 387344005019 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 387344005020 metal binding site 2 [ion binding]; metal-binding site 387344005021 putative DNA binding helix; other site 387344005022 metal binding site 1 [ion binding]; metal-binding site 387344005023 dimer interface [polypeptide binding]; other site 387344005024 structural Zn2+ binding site [ion binding]; other site 387344005025 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 387344005026 active site 387344005027 Ap4A binding cleft/pocket [chemical binding]; other site 387344005028 P4 phosphate binding site; other site 387344005029 nudix motif; other site 387344005030 putative P2/P3 phosphate binding site [ion binding]; other site 387344005031 amino acid transporter; Region: 2A0306; TIGR00909 387344005032 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 387344005033 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 387344005034 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 387344005035 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 387344005036 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 387344005037 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 387344005038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 387344005039 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 387344005040 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 387344005041 Walker A/P-loop; other site 387344005042 ATP binding site [chemical binding]; other site 387344005043 Q-loop/lid; other site 387344005044 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 387344005045 ABC transporter signature motif; other site 387344005046 Walker B; other site 387344005047 D-loop; other site 387344005048 ABC transporter; Region: ABC_tran_2; pfam12848 387344005049 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 387344005050 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 387344005051 dimer interface [polypeptide binding]; other site 387344005052 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 387344005053 metal binding site [ion binding]; metal-binding site 387344005054 CAAX protease self-immunity; Region: Abi; pfam02517 387344005055 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 387344005056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 387344005057 Walker A/P-loop; other site 387344005058 ATP binding site [chemical binding]; other site 387344005059 Q-loop/lid; other site 387344005060 ABC transporter signature motif; other site 387344005061 Walker B; other site 387344005062 D-loop; other site 387344005063 H-loop/switch region; other site 387344005064 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 387344005065 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 387344005066 TM-ABC transporter signature motif; other site 387344005067 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 387344005068 zinc binding site [ion binding]; other site 387344005069 putative ligand binding site [chemical binding]; other site 387344005070 EDD domain protein, DegV family; Region: DegV; TIGR00762 387344005071 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 387344005072 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 387344005073 zinc binding site [ion binding]; other site 387344005074 putative ligand binding site [chemical binding]; other site 387344005075 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 387344005076 TM-ABC transporter signature motif; other site 387344005077 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 387344005078 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 387344005079 Walker A/P-loop; other site 387344005080 ATP binding site [chemical binding]; other site 387344005081 Q-loop/lid; other site 387344005082 ABC transporter signature motif; other site 387344005083 Walker B; other site 387344005084 D-loop; other site 387344005085 H-loop/switch region; other site 387344005086 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 387344005087 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 387344005088 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 387344005089 SH3-like domain; Region: SH3_8; pfam13457 387344005090 Beta-lactamase; Region: Beta-lactamase; pfam00144 387344005091 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 387344005092 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 387344005093 Uncharacterized conserved protein [Function unknown]; Region: COG1434 387344005094 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 387344005095 putative active site [active] 387344005096 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 387344005097 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 387344005098 active site 387344005099 acetoin reductases; Region: 23BDH; TIGR02415 387344005100 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 387344005101 NAD(P) binding site [chemical binding]; other site 387344005102 active site 387344005103 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 387344005104 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 387344005105 Helix-turn-helix domain; Region: HTH_38; pfam13936 387344005106 Homeodomain-like domain; Region: HTH_32; pfam13565 387344005107 Integrase core domain; Region: rve; pfam00665 387344005108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344005109 Major Facilitator Superfamily; Region: MFS_1; pfam07690 387344005110 putative substrate translocation pore; other site 387344005111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344005112 Predicted transcriptional regulators [Transcription]; Region: COG1695 387344005113 Transcriptional regulator PadR-like family; Region: PadR; cl17335 387344005114 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 387344005115 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 387344005116 DNA binding residues [nucleotide binding] 387344005117 putative dimer interface [polypeptide binding]; other site 387344005118 NlpC/P60 family; Region: NLPC_P60; pfam00877 387344005119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 387344005120 Coenzyme A binding pocket [chemical binding]; other site 387344005121 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 387344005122 catalytic core [active] 387344005123 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 387344005124 Sulfatase; Region: Sulfatase; pfam00884 387344005125 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 387344005126 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 387344005127 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 387344005128 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 387344005129 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 387344005130 active site 387344005131 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 387344005132 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 387344005133 active site 387344005134 motif I; other site 387344005135 motif II; other site 387344005136 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 387344005137 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 387344005138 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 387344005139 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 387344005140 DNA binding residues [nucleotide binding] 387344005141 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 387344005142 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 387344005143 GIY-YIG motif/motif A; other site 387344005144 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 387344005145 Chloramphenicol acetyltransferase; Region: CAT; smart01059 387344005146 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 387344005147 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 387344005148 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 387344005149 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 387344005150 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 387344005151 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 387344005152 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 387344005153 Walker A/P-loop; other site 387344005154 ATP binding site [chemical binding]; other site 387344005155 Q-loop/lid; other site 387344005156 ABC transporter signature motif; other site 387344005157 Walker B; other site 387344005158 D-loop; other site 387344005159 H-loop/switch region; other site 387344005160 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 387344005161 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 387344005162 Walker A/P-loop; other site 387344005163 ATP binding site [chemical binding]; other site 387344005164 Q-loop/lid; other site 387344005165 ABC transporter signature motif; other site 387344005166 Walker B; other site 387344005167 D-loop; other site 387344005168 H-loop/switch region; other site 387344005169 Cobalt transport protein; Region: CbiQ; cl00463 387344005170 Putative transcription activator [Transcription]; Region: TenA; COG0819 387344005171 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 387344005172 active site 387344005173 homotetramer interface [polypeptide binding]; other site 387344005174 homodimer interface [polypeptide binding]; other site 387344005175 xanthine permease; Region: pbuX; TIGR03173 387344005176 Sulfate transporter family; Region: Sulfate_transp; pfam00916 387344005177 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 387344005178 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 387344005179 Walker A/P-loop; other site 387344005180 ATP binding site [chemical binding]; other site 387344005181 Q-loop/lid; other site 387344005182 ABC transporter signature motif; other site 387344005183 Walker B; other site 387344005184 D-loop; other site 387344005185 H-loop/switch region; other site 387344005186 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 387344005187 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 387344005188 Uncharacterized conserved protein [Function unknown]; Region: COG2966 387344005189 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 387344005190 EDD domain protein, DegV family; Region: DegV; TIGR00762 387344005191 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 387344005192 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 387344005193 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 387344005194 active site 387344005195 catalytic tetrad [active] 387344005196 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 387344005197 conserved hypothetical protein; Region: TIGR02328 387344005198 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 387344005199 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 387344005200 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 387344005201 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 387344005202 catalytic residue [active] 387344005203 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 387344005204 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 387344005205 putative switch regulator; other site 387344005206 non-specific DNA interactions [nucleotide binding]; other site 387344005207 DNA binding site [nucleotide binding] 387344005208 sequence specific DNA binding site [nucleotide binding]; other site 387344005209 putative cAMP binding site [chemical binding]; other site 387344005210 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 387344005211 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 387344005212 AIR carboxylase; Region: AIRC; smart01001 387344005213 Protein of unknown function DUF111; Region: DUF111; pfam01969 387344005214 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 387344005215 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 387344005216 Ligand Binding Site [chemical binding]; other site 387344005217 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 387344005218 amphipathic channel; other site 387344005219 Asn-Pro-Ala signature motifs; other site 387344005220 High-affinity nickel-transport protein; Region: NicO; cl00964 387344005221 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 387344005222 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 387344005223 Walker A/P-loop; other site 387344005224 ATP binding site [chemical binding]; other site 387344005225 Q-loop/lid; other site 387344005226 ABC transporter signature motif; other site 387344005227 Walker B; other site 387344005228 D-loop; other site 387344005229 H-loop/switch region; other site 387344005230 TOBE domain; Region: TOBE_2; pfam08402 387344005231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 387344005232 dimer interface [polypeptide binding]; other site 387344005233 conserved gate region; other site 387344005234 putative PBP binding loops; other site 387344005235 ABC-ATPase subunit interface; other site 387344005236 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 387344005237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 387344005238 dimer interface [polypeptide binding]; other site 387344005239 conserved gate region; other site 387344005240 putative PBP binding loops; other site 387344005241 ABC-ATPase subunit interface; other site 387344005242 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 387344005243 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 387344005244 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 387344005245 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 387344005246 Walker A/P-loop; other site 387344005247 ATP binding site [chemical binding]; other site 387344005248 Q-loop/lid; other site 387344005249 ABC transporter signature motif; other site 387344005250 Walker B; other site 387344005251 D-loop; other site 387344005252 H-loop/switch region; other site 387344005253 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 387344005254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 387344005255 dimer interface [polypeptide binding]; other site 387344005256 conserved gate region; other site 387344005257 putative PBP binding loops; other site 387344005258 ABC-ATPase subunit interface; other site 387344005259 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 387344005260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 387344005261 dimer interface [polypeptide binding]; other site 387344005262 conserved gate region; other site 387344005263 putative PBP binding loops; other site 387344005264 ABC-ATPase subunit interface; other site 387344005265 PBP superfamily domain; Region: PBP_like_2; cl17296 387344005266 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 387344005267 regulatory protein interface [polypeptide binding]; other site 387344005268 regulatory phosphorylation site [posttranslational modification]; other site 387344005269 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 387344005270 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 387344005271 DEAD_2; Region: DEAD_2; pfam06733 387344005272 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 387344005273 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 387344005274 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 387344005275 Walker A/P-loop; other site 387344005276 ATP binding site [chemical binding]; other site 387344005277 Q-loop/lid; other site 387344005278 ABC transporter signature motif; other site 387344005279 Walker B; other site 387344005280 D-loop; other site 387344005281 H-loop/switch region; other site 387344005282 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 387344005283 Helix-turn-helix domain; Region: HTH_38; pfam13936 387344005284 Integrase core domain; Region: rve; pfam00665 387344005285 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 387344005286 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 387344005287 active site 387344005288 ATP binding site [chemical binding]; other site 387344005289 substrate binding site [chemical binding]; other site 387344005290 activation loop (A-loop); other site 387344005291 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 387344005292 active site 387344005293 zinc binding site [ion binding]; other site 387344005294 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 387344005295 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 387344005296 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 387344005297 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 387344005298 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 387344005299 metal binding site 2 [ion binding]; metal-binding site 387344005300 putative DNA binding helix; other site 387344005301 metal binding site 1 [ion binding]; metal-binding site 387344005302 dimer interface [polypeptide binding]; other site 387344005303 structural Zn2+ binding site [ion binding]; other site 387344005304 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 387344005305 amidase catalytic site [active] 387344005306 Zn binding residues [ion binding]; other site 387344005307 substrate binding site [chemical binding]; other site 387344005308 YibE/F-like protein; Region: YibE_F; pfam07907 387344005309 YibE/F-like protein; Region: YibE_F; pfam07907 387344005310 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 387344005311 Ligand Binding Site [chemical binding]; other site 387344005312 Transcriptional regulators [Transcription]; Region: MarR; COG1846 387344005313 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 387344005314 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 387344005315 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 387344005316 active site 387344005317 Zn binding site [ion binding]; other site 387344005318 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 387344005319 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 387344005320 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 387344005321 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 387344005322 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 387344005323 DNA binding site [nucleotide binding] 387344005324 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 387344005325 putative dimerization interface [polypeptide binding]; other site 387344005326 putative ligand binding site [chemical binding]; other site 387344005327 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 387344005328 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 387344005329 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 387344005330 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 387344005331 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 387344005332 NAD binding site [chemical binding]; other site 387344005333 homodimer interface [polypeptide binding]; other site 387344005334 active site 387344005335 substrate binding site [chemical binding]; other site 387344005336 galactokinase; Provisional; Region: PRK05322 387344005337 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 387344005338 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 387344005339 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 387344005340 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 387344005341 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 387344005342 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 387344005343 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 387344005344 active site 387344005345 substrate binding site [chemical binding]; other site 387344005346 metal binding site [ion binding]; metal-binding site 387344005347 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 387344005348 active site 387344005349 catalytic residues [active] 387344005350 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 387344005351 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 387344005352 active site 387344005353 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 387344005354 Ligand binding site [chemical binding]; other site 387344005355 Electron transfer flavoprotein domain; Region: ETF; pfam01012 387344005356 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 387344005357 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 387344005358 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 387344005359 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 387344005360 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 387344005361 putative NAD(P) binding site [chemical binding]; other site 387344005362 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 387344005363 putative DNA binding site [nucleotide binding]; other site 387344005364 putative Zn2+ binding site [ion binding]; other site 387344005365 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 387344005366 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 387344005367 potential catalytic triad [active] 387344005368 conserved cys residue [active] 387344005369 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 387344005370 active site 387344005371 metal-binding site [ion binding] 387344005372 nucleotide-binding site [chemical binding]; other site 387344005373 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 387344005374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344005375 Major Facilitator Superfamily; Region: MFS_1; pfam07690 387344005376 putative substrate translocation pore; other site 387344005377 methionine aminopeptidase; Provisional; Region: PRK08671 387344005378 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 387344005379 active site 387344005380 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 387344005381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 387344005382 S-adenosylmethionine binding site [chemical binding]; other site 387344005383 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 387344005384 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 387344005385 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 387344005386 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 387344005387 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 387344005388 non-specific DNA binding site [nucleotide binding]; other site 387344005389 salt bridge; other site 387344005390 sequence-specific DNA binding site [nucleotide binding]; other site 387344005391 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 387344005392 active site 387344005393 DNA binding site [nucleotide binding] 387344005394 Uncharacterized conserved protein [Function unknown]; Region: COG3189 387344005395 beta-phosphoglucomutase; Region: bPGM; TIGR01990 387344005396 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 387344005397 motif II; other site 387344005398 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 387344005399 Ligand Binding Site [chemical binding]; other site 387344005400 BCCT family transporter; Region: BCCT; pfam02028 387344005401 maltose O-acetyltransferase; Provisional; Region: PRK10092 387344005402 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 387344005403 active site 387344005404 substrate binding site [chemical binding]; other site 387344005405 trimer interface [polypeptide binding]; other site 387344005406 CoA binding site [chemical binding]; other site 387344005407 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 387344005408 dimer interface [polypeptide binding]; other site 387344005409 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 387344005410 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 387344005411 RNA/DNA hybrid binding site [nucleotide binding]; other site 387344005412 active site 387344005413 cytosine deaminase; Provisional; Region: PRK09230 387344005414 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 387344005415 active site 387344005416 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 387344005417 dimer interface [polypeptide binding]; other site 387344005418 substrate binding site [chemical binding]; other site 387344005419 ATP binding site [chemical binding]; other site 387344005420 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 387344005421 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 387344005422 Helix-turn-helix domain; Region: HTH_38; pfam13936 387344005423 Homeodomain-like domain; Region: HTH_32; pfam13565 387344005424 Integrase core domain; Region: rve; pfam00665 387344005425 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 387344005426 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 387344005427 DNA-binding site [nucleotide binding]; DNA binding site 387344005428 RNA-binding motif; other site 387344005429 Predicted esterase [General function prediction only]; Region: COG0400 387344005430 putative hydrolase; Provisional; Region: PRK11460 387344005431 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 387344005432 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 387344005433 minor groove reading motif; other site 387344005434 helix-hairpin-helix signature motif; other site 387344005435 substrate binding pocket [chemical binding]; other site 387344005436 active site 387344005437 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 387344005438 DNA binding and oxoG recognition site [nucleotide binding] 387344005439 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 387344005440 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 387344005441 peptide binding site [polypeptide binding]; other site 387344005442 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 387344005443 MucBP domain; Region: MucBP; pfam06458 387344005444 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 387344005445 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 387344005446 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 387344005447 lipoyl attachment site [posttranslational modification]; other site 387344005448 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 387344005449 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 387344005450 active site 387344005451 catalytic tetrad [active] 387344005452 EamA-like transporter family; Region: EamA; pfam00892 387344005453 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 387344005454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 387344005455 dimer interface [polypeptide binding]; other site 387344005456 conserved gate region; other site 387344005457 ABC-ATPase subunit interface; other site 387344005458 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 387344005459 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 387344005460 Walker A/P-loop; other site 387344005461 ATP binding site [chemical binding]; other site 387344005462 Q-loop/lid; other site 387344005463 ABC transporter signature motif; other site 387344005464 Walker B; other site 387344005465 D-loop; other site 387344005466 H-loop/switch region; other site 387344005467 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 387344005468 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 387344005469 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 387344005470 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 387344005471 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 387344005472 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 387344005473 peptide binding site [polypeptide binding]; other site 387344005474 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 387344005475 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 387344005476 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 387344005477 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 387344005478 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 387344005479 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 387344005480 active site 387344005481 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 387344005482 AAA domain; Region: AAA_23; pfam13476 387344005483 Walker A/P-loop; other site 387344005484 ATP binding site [chemical binding]; other site 387344005485 Q-loop/lid; other site 387344005486 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 387344005487 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 387344005488 ABC transporter signature motif; other site 387344005489 Walker B; other site 387344005490 D-loop; other site 387344005491 H-loop/switch region; other site 387344005492 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 387344005493 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 387344005494 active site 387344005495 metal binding site [ion binding]; metal-binding site 387344005496 DNA binding site [nucleotide binding] 387344005497 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 387344005498 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 387344005499 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 387344005500 active site 387344005501 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 387344005502 active site 387344005503 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 387344005504 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 387344005505 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 387344005506 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 387344005507 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 387344005508 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 387344005509 DNA binding residues [nucleotide binding] 387344005510 putative dimer interface [polypeptide binding]; other site 387344005511 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 387344005512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 387344005513 Transcriptional regulators [Transcription]; Region: MarR; COG1846 387344005514 MarR family; Region: MarR_2; pfam12802 387344005515 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 387344005516 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 387344005517 active site 387344005518 catalytic tetrad [active] 387344005519 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 387344005520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344005521 putative substrate translocation pore; other site 387344005522 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 387344005523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344005524 putative substrate translocation pore; other site 387344005525 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 387344005526 phosphate binding site [ion binding]; other site 387344005527 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 387344005528 Hexamer/Pentamer interface [polypeptide binding]; other site 387344005529 central pore; other site 387344005530 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 387344005531 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 387344005532 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 387344005533 Walker A/P-loop; other site 387344005534 ATP binding site [chemical binding]; other site 387344005535 Q-loop/lid; other site 387344005536 ABC transporter signature motif; other site 387344005537 Walker B; other site 387344005538 D-loop; other site 387344005539 H-loop/switch region; other site 387344005540 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 387344005541 Walker A/P-loop; other site 387344005542 ATP binding site [chemical binding]; other site 387344005543 Q-loop/lid; other site 387344005544 ABC transporter signature motif; other site 387344005545 Walker B; other site 387344005546 D-loop; other site 387344005547 H-loop/switch region; other site 387344005548 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 387344005549 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 387344005550 Flavoprotein; Region: Flavoprotein; pfam02441 387344005551 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 387344005552 Transcriptional regulator [Transcription]; Region: LysR; COG0583 387344005553 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 387344005554 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 387344005555 dimerization interface [polypeptide binding]; other site 387344005556 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 387344005557 active site 387344005558 catalytic residues [active] 387344005559 metal binding site [ion binding]; metal-binding site 387344005560 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 387344005561 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 387344005562 active site 387344005563 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 387344005564 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 387344005565 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 387344005566 amphipathic channel; other site 387344005567 Asn-Pro-Ala signature motifs; other site 387344005568 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 387344005569 putative substrate binding pocket [chemical binding]; other site 387344005570 AC domain interface; other site 387344005571 catalytic triad [active] 387344005572 AB domain interface; other site 387344005573 interchain disulfide; other site 387344005574 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 387344005575 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 387344005576 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 387344005577 Walker A/P-loop; other site 387344005578 ATP binding site [chemical binding]; other site 387344005579 Q-loop/lid; other site 387344005580 ABC transporter signature motif; other site 387344005581 Walker B; other site 387344005582 D-loop; other site 387344005583 H-loop/switch region; other site 387344005584 MarR family; Region: MarR_2; cl17246 387344005585 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 387344005586 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 387344005587 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 387344005588 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 387344005589 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 387344005590 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 387344005591 Walker A/P-loop; other site 387344005592 ATP binding site [chemical binding]; other site 387344005593 Q-loop/lid; other site 387344005594 ABC transporter signature motif; other site 387344005595 Walker B; other site 387344005596 D-loop; other site 387344005597 H-loop/switch region; other site 387344005598 Predicted transcriptional regulators [Transcription]; Region: COG1725 387344005599 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 387344005600 DNA-binding site [nucleotide binding]; DNA binding site 387344005601 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 387344005602 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 387344005603 catalytic residues [active] 387344005604 dimer interface [polypeptide binding]; other site 387344005605 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 387344005606 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 387344005607 active site 387344005608 motif I; other site 387344005609 motif II; other site 387344005610 Major Facilitator Superfamily; Region: MFS_1; pfam07690 387344005611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344005612 putative substrate translocation pore; other site 387344005613 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 387344005614 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 387344005615 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 387344005616 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 387344005617 active site 387344005618 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 387344005619 classical (c) SDRs; Region: SDR_c; cd05233 387344005620 NAD(P) binding site [chemical binding]; other site 387344005621 active site 387344005622 Predicted transcriptional regulators [Transcription]; Region: COG1733 387344005623 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 387344005624 Asp23 family; Region: Asp23; pfam03780 387344005625 Asp23 family; Region: Asp23; pfam03780 387344005626 Predicted membrane protein [Function unknown]; Region: COG2261 387344005627 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 387344005628 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 387344005629 putative dimer interface [polypeptide binding]; other site 387344005630 putative anticodon binding site; other site 387344005631 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 387344005632 homodimer interface [polypeptide binding]; other site 387344005633 motif 1; other site 387344005634 motif 2; other site 387344005635 active site 387344005636 motif 3; other site 387344005637 Predicted transcriptional regulators [Transcription]; Region: COG1695 387344005638 Transcriptional regulator PadR-like family; Region: PadR; cl17335 387344005639 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 387344005640 B3/4 domain; Region: B3_4; pfam03483 387344005641 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 387344005642 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 387344005643 ligand binding site [chemical binding]; other site 387344005644 flexible hinge region; other site 387344005645 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 387344005646 carbamate kinase; Reviewed; Region: PRK12686 387344005647 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 387344005648 putative substrate binding site [chemical binding]; other site 387344005649 nucleotide binding site [chemical binding]; other site 387344005650 nucleotide binding site [chemical binding]; other site 387344005651 homodimer interface [polypeptide binding]; other site 387344005652 transaminase; Validated; Region: PRK07324 387344005653 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 387344005654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 387344005655 homodimer interface [polypeptide binding]; other site 387344005656 catalytic residue [active] 387344005657 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 387344005658 ornithine carbamoyltransferase; Validated; Region: PRK02102 387344005659 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 387344005660 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 387344005661 arginine deiminase; Provisional; Region: PRK01388 387344005662 Predicted membrane protein [Function unknown]; Region: COG1288 387344005663 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 387344005664 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 387344005665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 387344005666 ATP binding site [chemical binding]; other site 387344005667 Mg2+ binding site [ion binding]; other site 387344005668 G-X-G motif; other site 387344005669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 387344005670 Response regulator receiver domain; Region: Response_reg; pfam00072 387344005671 active site 387344005672 phosphorylation site [posttranslational modification] 387344005673 intermolecular recognition site; other site 387344005674 dimerization interface [polypeptide binding]; other site 387344005675 YcbB domain; Region: YcbB; pfam08664 387344005676 Predicted membrane protein [Function unknown]; Region: COG1288 387344005677 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 387344005678 hypothetical protein; Provisional; Region: PRK07205 387344005679 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 387344005680 active site 387344005681 metal binding site [ion binding]; metal-binding site 387344005682 Predicted membrane protein [Function unknown]; Region: COG3371 387344005683 Protein of unknown function (DUF998); Region: DUF998; pfam06197 387344005684 DJ-1 family protein; Region: not_thiJ; TIGR01383 387344005685 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 387344005686 conserved cys residue [active] 387344005687 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 387344005688 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 387344005689 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 387344005690 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 387344005691 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 387344005692 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 387344005693 Major Facilitator Superfamily; Region: MFS_1; pfam07690 387344005694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344005695 Protein of unknown function (DUF3781); Region: DUF3781; pfam12636 387344005696 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 387344005697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 387344005698 Coenzyme A binding pocket [chemical binding]; other site 387344005699 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 387344005700 catalytic core [active] 387344005701 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 387344005702 Collagen binding domain; Region: Collagen_bind; pfam05737 387344005703 Cna protein B-type domain; Region: Cna_B; pfam05738 387344005704 Cna protein B-type domain; Region: Cna_B; pfam05738 387344005705 Domain of unknown function DUF20; Region: UPF0118; pfam01594 387344005706 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 387344005707 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 387344005708 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 387344005709 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 387344005710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 387344005711 S-adenosylmethionine binding site [chemical binding]; other site 387344005712 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 387344005713 AzlC protein; Region: AzlC; cl00570 387344005714 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 387344005715 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 387344005716 Coenzyme A binding pocket [chemical binding]; other site 387344005717 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 387344005718 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 387344005719 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 387344005720 Predicted membrane protein [Function unknown]; Region: COG1511 387344005721 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 387344005722 Predicted membrane protein [Function unknown]; Region: COG1511 387344005723 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 387344005724 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 387344005725 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 387344005726 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 387344005727 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 387344005728 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 387344005729 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 387344005730 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 387344005731 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 387344005732 dimer interface [polypeptide binding]; other site 387344005733 phosphorylation site [posttranslational modification] 387344005734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 387344005735 ATP binding site [chemical binding]; other site 387344005736 Mg2+ binding site [ion binding]; other site 387344005737 G-X-G motif; other site 387344005738 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 387344005739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 387344005740 active site 387344005741 phosphorylation site [posttranslational modification] 387344005742 intermolecular recognition site; other site 387344005743 dimerization interface [polypeptide binding]; other site 387344005744 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 387344005745 DNA binding site [nucleotide binding] 387344005746 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 387344005747 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 387344005748 active site 387344005749 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 387344005750 GTP-binding protein YchF; Reviewed; Region: PRK09601 387344005751 YchF GTPase; Region: YchF; cd01900 387344005752 G1 box; other site 387344005753 GTP/Mg2+ binding site [chemical binding]; other site 387344005754 Switch I region; other site 387344005755 G2 box; other site 387344005756 Switch II region; other site 387344005757 G3 box; other site 387344005758 G4 box; other site 387344005759 G5 box; other site 387344005760 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 387344005761 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 387344005762 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 387344005763 ParB-like nuclease domain; Region: ParBc; pfam02195 387344005764 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 387344005765 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 387344005766 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 387344005767 Magnesium ion binding site [ion binding]; other site 387344005768 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 387344005769 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 387344005770 ParB-like nuclease domain; Region: ParBc; pfam02195 387344005771 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 387344005772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 387344005773 S-adenosylmethionine binding site [chemical binding]; other site 387344005774 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 387344005775 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 387344005776 active site 387344005777 metal binding site [ion binding]; metal-binding site 387344005778 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 387344005779 active site 387344005780 tetramer interface [polypeptide binding]; other site 387344005781 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 387344005782 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 387344005783 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 387344005784 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 387344005785 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 387344005786 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 387344005787 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 387344005788 Transposase; Region: DDE_Tnp_ISL3; pfam01610 387344005789 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 387344005790 NADH(P)-binding; Region: NAD_binding_10; pfam13460 387344005791 putative NAD(P) binding site [chemical binding]; other site 387344005792 MarR family; Region: MarR_2; pfam12802 387344005793 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 387344005794 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 387344005795 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 387344005796 pyridoxal 5'-phosphate binding site [chemical binding]; other site 387344005797 homodimer interface [polypeptide binding]; other site 387344005798 catalytic residue [active] 387344005799 Transcriptional regulator [Transcription]; Region: LysR; COG0583 387344005800 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 387344005801 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 387344005802 dimerization interface [polypeptide binding]; other site 387344005803 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 387344005804 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 387344005805 thiamine phosphate binding site [chemical binding]; other site 387344005806 active site 387344005807 pyrophosphate binding site [ion binding]; other site 387344005808 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 387344005809 substrate binding site [chemical binding]; other site 387344005810 dimer interface [polypeptide binding]; other site 387344005811 ATP binding site [chemical binding]; other site 387344005812 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 387344005813 substrate binding site [chemical binding]; other site 387344005814 multimerization interface [polypeptide binding]; other site 387344005815 ATP binding site [chemical binding]; other site 387344005816 short chain dehydrogenase; Validated; Region: PRK06182 387344005817 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 387344005818 NADP binding site [chemical binding]; other site 387344005819 active site 387344005820 steroid binding site; other site 387344005821 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 387344005822 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 387344005823 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 387344005824 Walker A/P-loop; other site 387344005825 ATP binding site [chemical binding]; other site 387344005826 Q-loop/lid; other site 387344005827 ABC transporter signature motif; other site 387344005828 Walker B; other site 387344005829 D-loop; other site 387344005830 H-loop/switch region; other site 387344005831 TRAM domain; Region: TRAM; cl01282 387344005832 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 387344005833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 387344005834 S-adenosylmethionine binding site [chemical binding]; other site 387344005835 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 387344005836 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 387344005837 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 387344005838 DNA binding residues [nucleotide binding] 387344005839 putative dimer interface [polypeptide binding]; other site 387344005840 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 387344005841 hydrophobic ligand binding site; other site 387344005842 Domain of unknown function (DUF368); Region: DUF368; cl00893 387344005843 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 387344005844 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 387344005845 DNA binding residues [nucleotide binding] 387344005846 dimer interface [polypeptide binding]; other site 387344005847 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 387344005848 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 387344005849 nucleotide binding site [chemical binding]; other site 387344005850 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 387344005851 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 387344005852 active site 387344005853 catalytic tetrad [active] 387344005854 recombination factor protein RarA; Reviewed; Region: PRK13342 387344005855 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 387344005856 Walker A motif; other site 387344005857 ATP binding site [chemical binding]; other site 387344005858 Walker B motif; other site 387344005859 arginine finger; other site 387344005860 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 387344005861 phosphodiesterase; Provisional; Region: PRK12704 387344005862 KH domain; Region: KH_1; pfam00013 387344005863 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 387344005864 Zn2+ binding site [ion binding]; other site 387344005865 Mg2+ binding site [ion binding]; other site 387344005866 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 387344005867 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 387344005868 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 387344005869 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 387344005870 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 387344005871 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 387344005872 active site 387344005873 Zn binding site [ion binding]; other site 387344005874 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 387344005875 non-specific DNA binding site [nucleotide binding]; other site 387344005876 salt bridge; other site 387344005877 sequence-specific DNA binding site [nucleotide binding]; other site 387344005878 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 387344005879 Uncharacterized conserved protein [Function unknown]; Region: COG1434 387344005880 putative active site [active] 387344005881 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 387344005882 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 387344005883 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 387344005884 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 387344005885 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 387344005886 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 387344005887 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 387344005888 MarR family; Region: MarR_2; cl17246 387344005889 MarR family; Region: MarR_2; cl17246 387344005890 Uncharacterized conserved protein [Function unknown]; Region: COG0062 387344005891 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 387344005892 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 387344005893 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 387344005894 active site 387344005895 NlpC/P60 family; Region: NLPC_P60; pfam00877 387344005896 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 387344005897 Transposase; Region: DDE_Tnp_ISL3; pfam01610 387344005898 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 387344005899 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 387344005900 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 387344005901 non-specific DNA binding site [nucleotide binding]; other site 387344005902 salt bridge; other site 387344005903 sequence-specific DNA binding site [nucleotide binding]; other site 387344005904 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 387344005905 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 387344005906 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 387344005907 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 387344005908 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 387344005909 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 387344005910 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 387344005911 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 387344005912 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 387344005913 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 387344005914 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 387344005915 active site 387344005916 metal binding site [ion binding]; metal-binding site 387344005917 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 387344005918 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 387344005919 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 387344005920 Transcriptional regulators [Transcription]; Region: PurR; COG1609 387344005921 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 387344005922 DNA binding site [nucleotide binding] 387344005923 domain linker motif; other site 387344005924 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 387344005925 dimerization interface [polypeptide binding]; other site 387344005926 ligand binding site [chemical binding]; other site 387344005927 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 387344005928 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 387344005929 hypothetical protein; Provisional; Region: PRK13690 387344005930 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 387344005931 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 387344005932 dimer interface [polypeptide binding]; other site 387344005933 substrate binding site [chemical binding]; other site 387344005934 ATP binding site [chemical binding]; other site 387344005935 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 387344005936 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 387344005937 DNA-binding site [nucleotide binding]; DNA binding site 387344005938 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 387344005939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 387344005940 homodimer interface [polypeptide binding]; other site 387344005941 catalytic residue [active] 387344005942 Transcriptional regulator [Transcription]; Region: LytR; COG1316 387344005943 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 387344005944 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 387344005945 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 387344005946 Walker A/P-loop; other site 387344005947 ATP binding site [chemical binding]; other site 387344005948 Q-loop/lid; other site 387344005949 ABC transporter signature motif; other site 387344005950 Walker B; other site 387344005951 D-loop; other site 387344005952 H-loop/switch region; other site 387344005953 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 387344005954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 387344005955 dimer interface [polypeptide binding]; other site 387344005956 conserved gate region; other site 387344005957 ABC-ATPase subunit interface; other site 387344005958 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 387344005959 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 387344005960 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 387344005961 active site 387344005962 metal binding site [ion binding]; metal-binding site 387344005963 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 387344005964 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 387344005965 putative NAD(P) binding site [chemical binding]; other site 387344005966 catalytic Zn binding site [ion binding]; other site 387344005967 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 387344005968 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 387344005969 nucleotide binding site [chemical binding]; other site 387344005970 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 387344005971 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 387344005972 dimer interface [polypeptide binding]; other site 387344005973 active site 387344005974 metal binding site [ion binding]; metal-binding site 387344005975 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 387344005976 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 387344005977 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 387344005978 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 387344005979 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 387344005980 catalytic core [active] 387344005981 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 387344005982 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 387344005983 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 387344005984 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 387344005985 Helix-turn-helix domain; Region: HTH_38; pfam13936 387344005986 Integrase core domain; Region: rve; pfam00665 387344005987 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 387344005988 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 387344005989 peptide binding site [polypeptide binding]; other site 387344005990 Transcriptional regulators [Transcription]; Region: PurR; COG1609 387344005991 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 387344005992 DNA binding site [nucleotide binding] 387344005993 domain linker motif; other site 387344005994 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 387344005995 dimerization interface [polypeptide binding]; other site 387344005996 ligand binding site [chemical binding]; other site 387344005997 Major Facilitator Superfamily; Region: MFS_1; pfam07690 387344005998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344005999 putative substrate translocation pore; other site 387344006000 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 387344006001 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 387344006002 Ca binding site [ion binding]; other site 387344006003 active site 387344006004 catalytic site [active] 387344006005 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 387344006006 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 387344006007 DNA binding residues [nucleotide binding] 387344006008 putative dimer interface [polypeptide binding]; other site 387344006009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 387344006010 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 387344006011 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 387344006012 putative active site [active] 387344006013 putative FMN binding site [chemical binding]; other site 387344006014 putative substrate binding site [chemical binding]; other site 387344006015 putative catalytic residue [active] 387344006016 Predicted transcriptional regulators [Transcription]; Region: COG1733 387344006017 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 387344006018 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 387344006019 putative dimer interface [polypeptide binding]; other site 387344006020 catalytic triad [active] 387344006021 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 387344006022 active site 387344006023 tetramer interface [polypeptide binding]; other site 387344006024 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 387344006025 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 387344006026 ligand binding site [chemical binding]; other site 387344006027 flexible hinge region; other site 387344006028 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 387344006029 Cation efflux family; Region: Cation_efflux; pfam01545 387344006030 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 387344006031 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 387344006032 dimer interface [polypeptide binding]; other site 387344006033 active site 387344006034 metal binding site [ion binding]; metal-binding site 387344006035 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 387344006036 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 387344006037 motif II; other site 387344006038 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 387344006039 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 387344006040 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 387344006041 substrate binding site [chemical binding]; other site 387344006042 D-galactonate transporter; Region: 2A0114; TIGR00893 387344006043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344006044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344006045 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 387344006046 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 387344006047 Walker A/P-loop; other site 387344006048 ATP binding site [chemical binding]; other site 387344006049 Q-loop/lid; other site 387344006050 ABC transporter signature motif; other site 387344006051 Walker B; other site 387344006052 D-loop; other site 387344006053 H-loop/switch region; other site 387344006054 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 387344006055 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 387344006056 FtsX-like permease family; Region: FtsX; pfam02687 387344006057 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 387344006058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 387344006059 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 387344006060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344006061 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 387344006062 Membrane transport protein; Region: Mem_trans; cl09117 387344006063 malate dehydrogenase; Provisional; Region: PRK13529 387344006064 Malic enzyme, N-terminal domain; Region: malic; pfam00390 387344006065 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 387344006066 NAD(P) binding site [chemical binding]; other site 387344006067 Transcriptional regulator [Transcription]; Region: LysR; COG0583 387344006068 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 387344006069 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 387344006070 dimerization interface [polypeptide binding]; other site 387344006071 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 387344006072 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 387344006073 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 387344006074 putative active site [active] 387344006075 agmatine deiminase; Region: agmatine_aguA; TIGR03380 387344006076 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 387344006077 carbamate kinase; Reviewed; Region: PRK12686 387344006078 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 387344006079 putative substrate binding site [chemical binding]; other site 387344006080 nucleotide binding site [chemical binding]; other site 387344006081 nucleotide binding site [chemical binding]; other site 387344006082 homodimer interface [polypeptide binding]; other site 387344006083 agmatine deiminase; Provisional; Region: PRK13551 387344006084 agmatine deiminase; Region: agmatine_aguA; TIGR03380 387344006085 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 387344006086 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 387344006087 putrescine carbamoyltransferase; Provisional; Region: PRK02255 387344006088 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 387344006089 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 387344006090 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 387344006091 Chromate transporter; Region: Chromate_transp; cl17781 387344006092 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 387344006093 tyrosine decarboxylase, Enterococcus type; Region: tyr_de_CO2_Ent; TIGR03811 387344006094 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 387344006095 catalytic residue [active] 387344006096 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 387344006097 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 387344006098 active site 387344006099 HIGH motif; other site 387344006100 dimer interface [polypeptide binding]; other site 387344006101 KMSKS motif; other site 387344006102 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 387344006103 RNA binding surface [nucleotide binding]; other site 387344006104 putative acyltransferase; Provisional; Region: PRK05790 387344006105 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 387344006106 dimer interface [polypeptide binding]; other site 387344006107 active site 387344006108 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 387344006109 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 387344006110 CsbD-like; Region: CsbD; cl17424 387344006111 Predicted membrane protein [Function unknown]; Region: COG2261 387344006112 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 387344006113 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 387344006114 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 387344006115 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 387344006116 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 387344006117 Protein of unknown function (DUF328); Region: DUF328; pfam03883 387344006118 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 387344006119 active site 387344006120 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 387344006121 active site 387344006122 dimer interface [polypeptide binding]; other site 387344006123 benzoate transport; Region: 2A0115; TIGR00895 387344006124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344006125 putative substrate translocation pore; other site 387344006126 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 387344006127 Protein of unknown function; Region: DUF3658; pfam12395 387344006128 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 387344006129 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 387344006130 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 387344006131 substrate binding site [chemical binding]; other site 387344006132 ATP binding site [chemical binding]; other site 387344006133 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 387344006134 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 387344006135 Na binding site [ion binding]; other site 387344006136 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 387344006137 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 387344006138 DNA-binding site [nucleotide binding]; DNA binding site 387344006139 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 387344006140 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 387344006141 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 387344006142 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 387344006143 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 387344006144 catalytic triad [active] 387344006145 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 387344006146 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 387344006147 G1 box; other site 387344006148 putative GEF interaction site [polypeptide binding]; other site 387344006149 GTP/Mg2+ binding site [chemical binding]; other site 387344006150 Switch I region; other site 387344006151 G2 box; other site 387344006152 G3 box; other site 387344006153 Switch II region; other site 387344006154 G4 box; other site 387344006155 G5 box; other site 387344006156 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 387344006157 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 387344006158 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 387344006159 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 387344006160 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 387344006161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 387344006162 homodimer interface [polypeptide binding]; other site 387344006163 catalytic residue [active] 387344006164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 387344006165 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 387344006166 NAD(P) binding site [chemical binding]; other site 387344006167 active site 387344006168 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 387344006169 Major Facilitator Superfamily; Region: MFS_1; pfam07690 387344006170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344006171 putative substrate translocation pore; other site 387344006172 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 387344006173 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 387344006174 active site 387344006175 substrate binding site [chemical binding]; other site 387344006176 trimer interface [polypeptide binding]; other site 387344006177 CoA binding site [chemical binding]; other site 387344006178 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 387344006179 active site 387344006180 zinc binding site [ion binding]; other site 387344006181 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 387344006182 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 387344006183 Walker A motif; other site 387344006184 ATP binding site [chemical binding]; other site 387344006185 Walker B motif; other site 387344006186 Uncharacterized conserved protein [Function unknown]; Region: COG3410 387344006187 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 387344006188 non-specific DNA binding site [nucleotide binding]; other site 387344006189 salt bridge; other site 387344006190 sequence-specific DNA binding site [nucleotide binding]; other site 387344006191 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 387344006192 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 387344006193 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 387344006194 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 387344006195 Predicted flavoprotein [General function prediction only]; Region: COG0431 387344006196 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 387344006197 Helix-turn-helix domain; Region: HTH_38; pfam13936 387344006198 Integrase core domain; Region: rve; pfam00665 387344006199 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 387344006200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 387344006201 dimer interface [polypeptide binding]; other site 387344006202 conserved gate region; other site 387344006203 putative PBP binding loops; other site 387344006204 ABC-ATPase subunit interface; other site 387344006205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 387344006206 dimer interface [polypeptide binding]; other site 387344006207 conserved gate region; other site 387344006208 putative PBP binding loops; other site 387344006209 ABC-ATPase subunit interface; other site 387344006210 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 387344006211 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 387344006212 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 387344006213 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 387344006214 Walker A/P-loop; other site 387344006215 ATP binding site [chemical binding]; other site 387344006216 Q-loop/lid; other site 387344006217 ABC transporter signature motif; other site 387344006218 Walker B; other site 387344006219 D-loop; other site 387344006220 H-loop/switch region; other site 387344006221 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 387344006222 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 387344006223 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 387344006224 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 387344006225 Predicted transcriptional regulator [Transcription]; Region: COG1959 387344006226 Transcriptional regulator; Region: Rrf2; pfam02082 387344006227 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 387344006228 legume lectins; Region: lectin_L-type; cl14058 387344006229 carbohydrate binding site [chemical binding]; other site 387344006230 metal binding site [ion binding]; metal-binding site 387344006231 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 387344006232 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 387344006233 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 387344006234 Part of AAA domain; Region: AAA_19; pfam13245 387344006235 Family description; Region: UvrD_C_2; pfam13538 387344006236 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 387344006237 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 387344006238 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 387344006239 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 387344006240 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 387344006241 metal binding site [ion binding]; metal-binding site 387344006242 dimer interface [polypeptide binding]; other site 387344006243 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 387344006244 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 387344006245 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 387344006246 NADH(P)-binding; Region: NAD_binding_10; pfam13460 387344006247 NAD(P) binding site [chemical binding]; other site 387344006248 active site 387344006249 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 387344006250 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 387344006251 active site 387344006252 catalytic tetrad [active] 387344006253 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 387344006254 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 387344006255 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 387344006256 putative Zn2+ binding site [ion binding]; other site 387344006257 putative DNA binding site [nucleotide binding]; other site 387344006258 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 387344006259 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 387344006260 Walker A/P-loop; other site 387344006261 ATP binding site [chemical binding]; other site 387344006262 Q-loop/lid; other site 387344006263 ABC transporter signature motif; other site 387344006264 Walker B; other site 387344006265 D-loop; other site 387344006266 H-loop/switch region; other site 387344006267 ABC-2 type transporter; Region: ABC2_membrane; cl17235 387344006268 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 387344006269 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 387344006270 UbiA prenyltransferase family; Region: UbiA; pfam01040 387344006271 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 387344006272 QueT transporter; Region: QueT; pfam06177 387344006273 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 387344006274 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 387344006275 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 387344006276 inhibitor binding site; inhibition site 387344006277 active site 387344006278 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 387344006279 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 387344006280 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 387344006281 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 387344006282 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 387344006283 Helix-turn-helix domain; Region: HTH_18; pfam12833 387344006284 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 387344006285 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 387344006286 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 387344006287 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 387344006288 putative active site [active] 387344006289 catalytic site [active] 387344006290 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 387344006291 putative active site [active] 387344006292 catalytic site [active] 387344006293 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 387344006294 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 387344006295 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 387344006296 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 387344006297 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 387344006298 motif II; other site 387344006299 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 387344006300 trimer interface [polypeptide binding]; other site 387344006301 active site 387344006302 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 387344006303 MarR family; Region: MarR_2; pfam12802 387344006304 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 387344006305 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 387344006306 Catalytic site [active] 387344006307 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 387344006308 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 387344006309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 387344006310 putative substrate translocation pore; other site 387344006311 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 387344006312 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 387344006313 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 387344006314 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 387344006315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 387344006316 NADH(P)-binding; Region: NAD_binding_10; pfam13460 387344006317 NAD(P) binding site [chemical binding]; other site 387344006318 active site 387344006319 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 387344006320 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 387344006321 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 387344006322 motif II; other site 387344006323 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 387344006324 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 387344006325 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 387344006326 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 387344006327 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 387344006328 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 387344006329 trmE is a tRNA modification GTPase; Region: trmE; cd04164 387344006330 G1 box; other site 387344006331 GTP/Mg2+ binding site [chemical binding]; other site 387344006332 Switch I region; other site 387344006333 G2 box; other site 387344006334 Switch II region; other site 387344006335 G3 box; other site 387344006336 G4 box; other site 387344006337 G5 box; other site 387344006338 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 387344006339 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 387344006340 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 387344006341 G-X-X-G motif; other site 387344006342 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 387344006343 RxxxH motif; other site 387344006344 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 387344006345 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 387344006346 ribonuclease P; Reviewed; Region: rnpA; PRK00499 387344006347 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 387344006348 RelB antitoxin; Region: RelB; cl01171 387344006349 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 387344006350 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 387344006351 Walker A motif; other site 387344006352 ATP binding site [chemical binding]; other site 387344006353 Walker B motif; other site 387344006354 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 387344006355 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 387344006356 non-specific DNA binding site [nucleotide binding]; other site 387344006357 salt bridge; other site 387344006358 sequence-specific DNA binding site [nucleotide binding]; other site 387344006359 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 387344006360 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 387344006361 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 387344006362 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 387344006363 non-specific DNA binding site [nucleotide binding]; other site 387344006364 salt bridge; other site 387344006365 sequence-specific DNA binding site [nucleotide binding]; other site 387344006366 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 387344006367 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 387344006368 non-specific DNA binding site [nucleotide binding]; other site 387344006369 salt bridge; other site 387344006370 sequence-specific DNA binding site [nucleotide binding]; other site 387344006371 MobA/MobL family; Region: MobA_MobL; pfam03389 387344006372 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 387344006373 multiple promoter invertase; Provisional; Region: mpi; PRK13413 387344006374 catalytic residues [active] 387344006375 catalytic nucleophile [active] 387344006376 Presynaptic Site I dimer interface [polypeptide binding]; other site 387344006377 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 387344006378 Synaptic Flat tetramer interface [polypeptide binding]; other site 387344006379 Synaptic Site I dimer interface [polypeptide binding]; other site 387344006380 DNA binding site [nucleotide binding] 387344006381 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 387344006382 DNA-binding interface [nucleotide binding]; DNA binding site 387344006383 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 387344006384 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 387344006385 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 387344006386 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 387344006387 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 387344006388 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 387344006389 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 387344006390 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 387344006391 Integrase core domain; Region: rve; pfam00665 387344006392 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 387344006393 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 387344006394 P loop; other site 387344006395 Nucleotide binding site [chemical binding]; other site 387344006396 DTAP/Switch II; other site 387344006397 Switch I; other site 387344006398 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 387344006399 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 387344006400 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 387344006401 catalytic residues [active] 387344006402 catalytic nucleophile [active] 387344006403 Presynaptic Site I dimer interface [polypeptide binding]; other site 387344006404 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 387344006405 Synaptic Flat tetramer interface [polypeptide binding]; other site 387344006406 Synaptic Site I dimer interface [polypeptide binding]; other site 387344006407 DNA binding site [nucleotide binding] 387344006408 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 387344006409 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 387344006410 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 387344006411 Magnesium ion binding site [ion binding]; other site 387344006412 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 387344006413 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 387344006414 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 387344006415 active site 387344006416 DNA binding site [nucleotide binding] 387344006417 Int/Topo IB signature motif; other site 387344006418 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 387344006419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 387344006420 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 387344006421 DEAD-like helicases superfamily; Region: DEXDc; smart00487 387344006422 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 387344006423 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 387344006424 ATP binding site [chemical binding]; other site 387344006425 putative Mg++ binding site [ion binding]; other site 387344006426 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 387344006427 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 387344006428 Initiator Replication protein; Region: Rep_3; pfam01051