-- dump date 20140619_122542 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1001583000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1001583000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1001583000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001583000004 Walker A motif; other site 1001583000005 ATP binding site [chemical binding]; other site 1001583000006 Walker B motif; other site 1001583000007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1001583000008 arginine finger; other site 1001583000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1001583000010 DnaA box-binding interface [nucleotide binding]; other site 1001583000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 1001583000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1001583000013 putative DNA binding surface [nucleotide binding]; other site 1001583000014 dimer interface [polypeptide binding]; other site 1001583000015 beta-clamp/clamp loader binding surface; other site 1001583000016 beta-clamp/translesion DNA polymerase binding surface; other site 1001583000017 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1001583000018 recombination protein F; Reviewed; Region: recF; PRK00064 1001583000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1001583000020 Walker A/P-loop; other site 1001583000021 ATP binding site [chemical binding]; other site 1001583000022 Q-loop/lid; other site 1001583000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001583000024 ABC transporter signature motif; other site 1001583000025 Walker B; other site 1001583000026 D-loop; other site 1001583000027 H-loop/switch region; other site 1001583000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1001583000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001583000030 Mg2+ binding site [ion binding]; other site 1001583000031 G-X-G motif; other site 1001583000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1001583000033 anchoring element; other site 1001583000034 dimer interface [polypeptide binding]; other site 1001583000035 ATP binding site [chemical binding]; other site 1001583000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1001583000037 active site 1001583000038 putative metal-binding site [ion binding]; other site 1001583000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1001583000040 DNA gyrase subunit A; Validated; Region: PRK05560 1001583000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1001583000042 CAP-like domain; other site 1001583000043 active site 1001583000044 primary dimer interface [polypeptide binding]; other site 1001583000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1001583000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1001583000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1001583000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1001583000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1001583000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1001583000051 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1001583000052 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1001583000053 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1001583000054 dimer interface [polypeptide binding]; other site 1001583000055 ssDNA binding site [nucleotide binding]; other site 1001583000056 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1001583000057 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1001583000058 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1001583000059 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1001583000060 Amidohydrolase; Region: Amidohydro_4; pfam13147 1001583000061 active site 1001583000062 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1001583000063 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1001583000064 peptide binding site [polypeptide binding]; other site 1001583000065 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1001583000066 Amidohydrolase; Region: Amidohydro_4; pfam13147 1001583000067 active site 1001583000068 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1001583000069 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1001583000070 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1001583000071 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1001583000072 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001583000073 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001583000074 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1001583000075 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1001583000076 DHH family; Region: DHH; pfam01368 1001583000077 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1001583000078 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1001583000079 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1001583000080 replicative DNA helicase; Provisional; Region: PRK05748 1001583000081 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1001583000082 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1001583000083 Walker A motif; other site 1001583000084 ATP binding site [chemical binding]; other site 1001583000085 Walker B motif; other site 1001583000086 DNA binding loops [nucleotide binding] 1001583000087 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1001583000088 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1001583000089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583000090 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001583000091 putative substrate translocation pore; other site 1001583000092 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1001583000093 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1001583000094 peptide binding site [polypeptide binding]; other site 1001583000095 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1001583000096 active site 1001583000097 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1001583000098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001583000099 active site 1001583000100 phosphorylation site [posttranslational modification] 1001583000101 intermolecular recognition site; other site 1001583000102 dimerization interface [polypeptide binding]; other site 1001583000103 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1001583000104 DNA binding site [nucleotide binding] 1001583000105 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1001583000106 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1001583000107 dimerization interface [polypeptide binding]; other site 1001583000108 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1001583000109 putative active site [active] 1001583000110 heme pocket [chemical binding]; other site 1001583000111 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1001583000112 dimer interface [polypeptide binding]; other site 1001583000113 phosphorylation site [posttranslational modification] 1001583000114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001583000115 ATP binding site [chemical binding]; other site 1001583000116 Mg2+ binding site [ion binding]; other site 1001583000117 G-X-G motif; other site 1001583000118 YycH protein; Region: YycH; pfam07435 1001583000119 YycH protein; Region: YycI; pfam09648 1001583000120 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1001583000121 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1001583000122 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1001583000123 protein binding site [polypeptide binding]; other site 1001583000124 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1001583000125 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583000126 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583000127 Integrase core domain; Region: rve; pfam00665 1001583000128 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1001583000129 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1001583000130 substrate binding pocket [chemical binding]; other site 1001583000131 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1001583000132 maltose O-acetyltransferase; Provisional; Region: PRK10092 1001583000133 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1001583000134 active site 1001583000135 substrate binding site [chemical binding]; other site 1001583000136 trimer interface [polypeptide binding]; other site 1001583000137 CoA binding site [chemical binding]; other site 1001583000138 Cadmium resistance transporter; Region: Cad; pfam03596 1001583000139 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1001583000140 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1001583000141 Predicted membrane protein [Function unknown]; Region: COG2246 1001583000142 GtrA-like protein; Region: GtrA; pfam04138 1001583000143 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1001583000144 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1001583000145 peptide binding site [polypeptide binding]; other site 1001583000146 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001583000147 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001583000148 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1001583000149 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1001583000150 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1001583000151 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1001583000152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 1001583000153 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 1001583000154 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 1001583000155 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1001583000156 CoenzymeA binding site [chemical binding]; other site 1001583000157 subunit interaction site [polypeptide binding]; other site 1001583000158 PHB binding site; other site 1001583000159 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1001583000160 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1001583000161 substrate binding site [chemical binding]; other site 1001583000162 oxyanion hole (OAH) forming residues; other site 1001583000163 trimer interface [polypeptide binding]; other site 1001583000164 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1001583000165 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1001583000166 acyl-activating enzyme (AAE) consensus motif; other site 1001583000167 putative AMP binding site [chemical binding]; other site 1001583000168 putative active site [active] 1001583000169 putative CoA binding site [chemical binding]; other site 1001583000170 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1001583000171 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 1001583000172 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1001583000173 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1001583000174 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1001583000175 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1001583000176 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1001583000177 dimer interface [polypeptide binding]; other site 1001583000178 putative anticodon binding site; other site 1001583000179 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1001583000180 motif 1; other site 1001583000181 active site 1001583000182 motif 2; other site 1001583000183 motif 3; other site 1001583000184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583000185 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001583000186 putative substrate translocation pore; other site 1001583000187 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001583000188 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001583000189 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1001583000190 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1001583000191 putative NAD(P) binding site [chemical binding]; other site 1001583000192 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1001583000193 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 1001583000194 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1001583000195 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 1001583000196 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1001583000197 catalytic residue [active] 1001583000198 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1001583000199 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1001583000200 HIGH motif; other site 1001583000201 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1001583000202 active site 1001583000203 KMSKS motif; other site 1001583000204 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1001583000205 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1001583000206 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1001583000207 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1001583000208 peroxiredoxin; Region: AhpC; TIGR03137 1001583000209 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1001583000210 dimer interface [polypeptide binding]; other site 1001583000211 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1001583000212 catalytic triad [active] 1001583000213 peroxidatic and resolving cysteines [active] 1001583000214 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1001583000215 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1001583000216 NAD(P) binding site [chemical binding]; other site 1001583000217 putative active site [active] 1001583000218 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001583000219 non-specific DNA binding site [nucleotide binding]; other site 1001583000220 salt bridge; other site 1001583000221 sequence-specific DNA binding site [nucleotide binding]; other site 1001583000222 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1001583000223 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1001583000224 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1001583000225 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1001583000226 MarR family; Region: MarR_2; pfam12802 1001583000227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1001583000228 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1001583000229 Coenzyme A binding pocket [chemical binding]; other site 1001583000230 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1001583000231 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1001583000232 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1001583000233 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 1001583000234 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1001583000235 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1001583000236 active site 1001583000237 catalytic tetrad [active] 1001583000238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583000239 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001583000240 putative substrate translocation pore; other site 1001583000241 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1001583000242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583000243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583000244 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1001583000245 dimer interface [polypeptide binding]; other site 1001583000246 FMN binding site [chemical binding]; other site 1001583000247 NADPH bind site [chemical binding]; other site 1001583000248 flavoprotein NrdI; Provisional; Region: PRK02551 1001583000249 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1001583000250 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1001583000251 ABC transporter; Region: ABC_tran_2; pfam12848 1001583000252 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1001583000253 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1001583000254 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001583000255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583000256 putative substrate translocation pore; other site 1001583000257 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1001583000258 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1001583000259 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1001583000260 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1001583000261 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1001583000262 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1001583000263 Uncharacterized conserved protein [Function unknown]; Region: COG5604 1001583000264 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 1001583000265 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1001583000266 NADP binding site [chemical binding]; other site 1001583000267 homodimer interface [polypeptide binding]; other site 1001583000268 active site 1001583000269 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1001583000270 DNA binding site [nucleotide binding] 1001583000271 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 1001583000272 domain linker motif; other site 1001583000273 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1001583000274 putative dimerization interface [polypeptide binding]; other site 1001583000275 putative ligand binding site [chemical binding]; other site 1001583000276 Domain of unknown function DUF21; Region: DUF21; pfam01595 1001583000277 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1001583000278 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1001583000279 Transporter associated domain; Region: CorC_HlyC; smart01091 1001583000280 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1001583000281 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 1001583000282 putative dimer interface [polypeptide binding]; other site 1001583000283 inner membrane transporter YjeM; Provisional; Region: PRK15238 1001583000284 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1001583000285 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1001583000286 active site 1001583000287 catalytic tetrad [active] 1001583000288 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1001583000289 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1001583000290 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1001583000291 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1001583000292 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 1001583000293 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1001583000294 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1001583000295 putative active site [active] 1001583000296 catalytic site [active] 1001583000297 putative metal binding site [ion binding]; other site 1001583000298 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1001583000299 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1001583000300 putative catalytic cysteine [active] 1001583000301 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1001583000302 putative active site [active] 1001583000303 metal binding site [ion binding]; metal-binding site 1001583000304 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1001583000305 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001583000306 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1001583000307 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1001583000308 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1001583000309 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1001583000310 MucBP domain; Region: MucBP; pfam06458 1001583000311 MucBP domain; Region: MucBP; pfam06458 1001583000312 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1001583000313 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001583000314 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001583000315 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1001583000316 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1001583000317 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1001583000318 substrate binding site [chemical binding]; other site 1001583000319 ATP binding site [chemical binding]; other site 1001583000320 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1001583000321 propionate/acetate kinase; Provisional; Region: PRK12379 1001583000322 3D domain; Region: 3D; cl01439 1001583000323 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1001583000324 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1001583000325 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1001583000326 Walker A/P-loop; other site 1001583000327 ATP binding site [chemical binding]; other site 1001583000328 Q-loop/lid; other site 1001583000329 ABC transporter signature motif; other site 1001583000330 Walker B; other site 1001583000331 D-loop; other site 1001583000332 H-loop/switch region; other site 1001583000333 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1001583000334 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1001583000335 Zn2+ binding site [ion binding]; other site 1001583000336 Mg2+ binding site [ion binding]; other site 1001583000337 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1001583000338 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1001583000339 Glucuronate isomerase; Region: UxaC; pfam02614 1001583000340 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1001583000341 MFS/sugar transport protein; Region: MFS_2; pfam13347 1001583000342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583000343 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1001583000344 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1001583000345 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 1001583000346 putative active site [active] 1001583000347 putative catalytic site [active] 1001583000348 beta-D-glucuronidase; Provisional; Region: PRK10150 1001583000349 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1001583000350 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1001583000351 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1001583000352 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1001583000353 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1001583000354 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1001583000355 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1001583000356 active site 1001583000357 catalytic residues [active] 1001583000358 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1001583000359 catalytic core [active] 1001583000360 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_12; cd12177 1001583000361 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1001583000362 putative ligand binding site [chemical binding]; other site 1001583000363 putative NAD binding site [chemical binding]; other site 1001583000364 catalytic site [active] 1001583000365 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1001583000366 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1001583000367 N- and C-terminal domain interface [polypeptide binding]; other site 1001583000368 active site 1001583000369 catalytic site [active] 1001583000370 metal binding site [ion binding]; metal-binding site 1001583000371 carbohydrate binding site [chemical binding]; other site 1001583000372 ATP binding site [chemical binding]; other site 1001583000373 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1001583000374 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1001583000375 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1001583000376 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001583000377 DNA-binding site [nucleotide binding]; DNA binding site 1001583000378 FCD domain; Region: FCD; pfam07729 1001583000379 mannonate dehydratase; Provisional; Region: PRK03906 1001583000380 mannonate dehydratase; Region: uxuA; TIGR00695 1001583000381 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1001583000382 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1001583000383 DNA binding site [nucleotide binding] 1001583000384 domain linker motif; other site 1001583000385 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1001583000386 ligand binding site [chemical binding]; other site 1001583000387 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1001583000388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583000389 putative substrate translocation pore; other site 1001583000390 Glucuronate isomerase; Region: UxaC; pfam02614 1001583000391 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1001583000392 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 1001583000393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583000394 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001583000395 putative substrate translocation pore; other site 1001583000396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583000397 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 1001583000398 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1001583000399 putative deacylase active site [active] 1001583000400 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001583000401 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1001583000402 DNA-binding site [nucleotide binding]; DNA binding site 1001583000403 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1001583000404 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 1001583000405 active site 1001583000406 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1001583000407 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1001583000408 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1001583000409 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1001583000410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001583000411 active site 1001583000412 phosphorylation site [posttranslational modification] 1001583000413 intermolecular recognition site; other site 1001583000414 dimerization interface [polypeptide binding]; other site 1001583000415 LytTr DNA-binding domain; Region: LytTR; pfam04397 1001583000416 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1001583000417 ATP binding site [chemical binding]; other site 1001583000418 Mg2+ binding site [ion binding]; other site 1001583000419 G-X-G motif; other site 1001583000420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001583000421 short chain dehydrogenase; Validated; Region: PRK07069 1001583000422 NAD(P) binding site [chemical binding]; other site 1001583000423 active site 1001583000424 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1001583000425 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1001583000426 active site 1001583000427 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1001583000428 Ligand Binding Site [chemical binding]; other site 1001583000429 Cation efflux family; Region: Cation_efflux; pfam01545 1001583000430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583000431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583000432 putative substrate translocation pore; other site 1001583000433 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001583000434 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001583000435 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 1001583000436 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1001583000437 peptide binding site [polypeptide binding]; other site 1001583000438 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 1001583000439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001583000440 dimer interface [polypeptide binding]; other site 1001583000441 conserved gate region; other site 1001583000442 putative PBP binding loops; other site 1001583000443 ABC-ATPase subunit interface; other site 1001583000444 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1001583000445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001583000446 dimer interface [polypeptide binding]; other site 1001583000447 conserved gate region; other site 1001583000448 putative PBP binding loops; other site 1001583000449 ABC-ATPase subunit interface; other site 1001583000450 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1001583000451 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1001583000452 Walker A/P-loop; other site 1001583000453 ATP binding site [chemical binding]; other site 1001583000454 Q-loop/lid; other site 1001583000455 ABC transporter signature motif; other site 1001583000456 Walker B; other site 1001583000457 D-loop; other site 1001583000458 H-loop/switch region; other site 1001583000459 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1001583000460 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1001583000461 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1001583000462 Walker A/P-loop; other site 1001583000463 ATP binding site [chemical binding]; other site 1001583000464 Q-loop/lid; other site 1001583000465 ABC transporter signature motif; other site 1001583000466 Walker B; other site 1001583000467 D-loop; other site 1001583000468 H-loop/switch region; other site 1001583000469 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1001583000470 Predicted transcriptional regulator [Transcription]; Region: COG1959 1001583000471 Transcriptional regulator; Region: Rrf2; pfam02082 1001583000472 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1001583000473 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1001583000474 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1001583000475 xylose isomerase; Provisional; Region: PRK05474 1001583000476 xylose isomerase; Region: xylose_isom_A; TIGR02630 1001583000477 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1001583000478 N- and C-terminal domain interface [polypeptide binding]; other site 1001583000479 D-xylulose kinase; Region: XylB; TIGR01312 1001583000480 active site 1001583000481 MgATP binding site [chemical binding]; other site 1001583000482 catalytic site [active] 1001583000483 metal binding site [ion binding]; metal-binding site 1001583000484 xylulose binding site [chemical binding]; other site 1001583000485 homodimer interface [polypeptide binding]; other site 1001583000486 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1001583000487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583000488 putative substrate translocation pore; other site 1001583000489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583000490 acetoin reductase; Validated; Region: PRK08643 1001583000491 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1001583000492 NAD binding site [chemical binding]; other site 1001583000493 homotetramer interface [polypeptide binding]; other site 1001583000494 homodimer interface [polypeptide binding]; other site 1001583000495 active site 1001583000496 substrate binding site [chemical binding]; other site 1001583000497 Uncharacterized conserved protein [Function unknown]; Region: COG5646 1001583000498 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1001583000499 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1001583000500 Ligand Binding Site [chemical binding]; other site 1001583000501 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1001583000502 substrate binding site [chemical binding]; other site 1001583000503 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1001583000504 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1001583000505 metal binding site [ion binding]; metal-binding site 1001583000506 dimer interface [polypeptide binding]; other site 1001583000507 Ion transport protein; Region: Ion_trans; pfam00520 1001583000508 Ion channel; Region: Ion_trans_2; pfam07885 1001583000509 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1001583000510 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1001583000511 active site 1001583000512 catalytic tetrad [active] 1001583000513 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001583000514 Coenzyme A binding pocket [chemical binding]; other site 1001583000515 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1001583000516 Membrane transport protein; Region: Mem_trans; cl09117 1001583000517 (R)-2-Hydroxyglutarate Dehydrogenase and related dehydrogenases, NAD-binding and catalytic domains; Region: HGDH_like; cd12184 1001583000518 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1001583000519 putative homodimer interface [polypeptide binding]; other site 1001583000520 putative ligand binding site [chemical binding]; other site 1001583000521 putative NAD binding site [chemical binding]; other site 1001583000522 catalytic site [active] 1001583000523 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1001583000524 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1001583000525 PAS domain; Region: PAS; smart00091 1001583000526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001583000527 ATP binding site [chemical binding]; other site 1001583000528 Mg2+ binding site [ion binding]; other site 1001583000529 G-X-G motif; other site 1001583000530 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1001583000531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001583000532 active site 1001583000533 phosphorylation site [posttranslational modification] 1001583000534 intermolecular recognition site; other site 1001583000535 dimerization interface [polypeptide binding]; other site 1001583000536 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1001583000537 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1001583000538 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001583000539 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001583000540 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1001583000541 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1001583000542 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1001583000543 Double zinc ribbon; Region: DZR; pfam12773 1001583000544 Predicted membrane protein [Function unknown]; Region: COG4640 1001583000545 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1001583000546 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1001583000547 nudix motif; other site 1001583000548 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1001583000549 Predicted transcriptional regulators [Transcription]; Region: COG1695 1001583000550 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1001583000551 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1001583000552 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 1001583000553 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1001583000554 NADP binding site [chemical binding]; other site 1001583000555 putative substrate binding site [chemical binding]; other site 1001583000556 active site 1001583000557 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1001583000558 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001583000559 MarR family; Region: MarR; pfam01047 1001583000560 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 1001583000561 Cadmium resistance transporter; Region: Cad; pfam03596 1001583000562 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1001583000563 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1001583000564 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1001583000565 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1001583000566 Ligand Binding Site [chemical binding]; other site 1001583000567 manganese transport protein MntH; Reviewed; Region: PRK00701 1001583000568 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1001583000569 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1001583000570 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1001583000571 active site 1001583000572 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1001583000573 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1001583000574 GDP-binding site [chemical binding]; other site 1001583000575 ACT binding site; other site 1001583000576 IMP binding site; other site 1001583000577 adenylosuccinate lyase; Provisional; Region: PRK07492 1001583000578 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1001583000579 tetramer interface [polypeptide binding]; other site 1001583000580 active site 1001583000581 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001583000582 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001583000583 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1001583000584 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1001583000585 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1001583000586 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1001583000587 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1001583000588 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1001583000589 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1001583000590 peptidase domain interface [polypeptide binding]; other site 1001583000591 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 1001583000592 active site 1001583000593 catalytic triad [active] 1001583000594 calcium binding site [ion binding]; other site 1001583000595 Predicted membrane protein [Function unknown]; Region: COG2364 1001583000596 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1001583000597 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1001583000598 catalytic triad [active] 1001583000599 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1001583000600 endonuclease III; Region: ENDO3c; smart00478 1001583000601 minor groove reading motif; other site 1001583000602 helix-hairpin-helix signature motif; other site 1001583000603 substrate binding pocket [chemical binding]; other site 1001583000604 active site 1001583000605 glycerol kinase; Provisional; Region: glpK; PRK00047 1001583000606 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1001583000607 N- and C-terminal domain interface [polypeptide binding]; other site 1001583000608 active site 1001583000609 MgATP binding site [chemical binding]; other site 1001583000610 catalytic site [active] 1001583000611 metal binding site [ion binding]; metal-binding site 1001583000612 glycerol binding site [chemical binding]; other site 1001583000613 homotetramer interface [polypeptide binding]; other site 1001583000614 homodimer interface [polypeptide binding]; other site 1001583000615 FBP binding site [chemical binding]; other site 1001583000616 protein IIAGlc interface [polypeptide binding]; other site 1001583000617 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1001583000618 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1001583000619 NlpC/P60 family; Region: NLPC_P60; cl17555 1001583000620 SH3-like domain; Region: SH3_8; pfam13457 1001583000621 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 1001583000622 putative active site [active] 1001583000623 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1001583000624 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1001583000625 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1001583000626 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1001583000627 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1001583000628 Helix-turn-helix domain; Region: HTH_18; pfam12833 1001583000629 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1001583000630 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1001583000631 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1001583000632 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1001583000633 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1001583000634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583000635 MFS/sugar transport protein; Region: MFS_2; pfam13347 1001583000636 putative substrate translocation pore; other site 1001583000637 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1001583000638 Isochorismatase family; Region: Isochorismatase; pfam00857 1001583000639 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1001583000640 catalytic triad [active] 1001583000641 conserved cis-peptide bond; other site 1001583000642 Predicted transcriptional regulators [Transcription]; Region: COG1695 1001583000643 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1001583000644 Predicted membrane protein [Function unknown]; Region: COG4709 1001583000645 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1001583000646 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1001583000647 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1001583000648 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1001583000649 FMN binding site [chemical binding]; other site 1001583000650 active site 1001583000651 catalytic residues [active] 1001583000652 substrate binding site [chemical binding]; other site 1001583000653 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 1001583000654 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 1001583000655 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 1001583000656 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 1001583000657 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1001583000658 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1001583000659 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1001583000660 putative transport protein YifK; Provisional; Region: PRK10746 1001583000661 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1001583000662 legume lectins; Region: lectin_L-type; cl14058 1001583000663 homotetramer interaction site [polypeptide binding]; other site 1001583000664 carbohydrate binding site [chemical binding]; other site 1001583000665 metal binding site [ion binding]; metal-binding site 1001583000666 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1001583000667 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1001583000668 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1001583000669 metal binding site [ion binding]; metal-binding site 1001583000670 dimer interface [polypeptide binding]; other site 1001583000671 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1001583000672 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1001583000673 NAD binding site [chemical binding]; other site 1001583000674 substrate binding site [chemical binding]; other site 1001583000675 catalytic Zn binding site [ion binding]; other site 1001583000676 tetramer interface [polypeptide binding]; other site 1001583000677 structural Zn binding site [ion binding]; other site 1001583000678 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001583000679 putative DNA binding site [nucleotide binding]; other site 1001583000680 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1001583000681 putative Zn2+ binding site [ion binding]; other site 1001583000682 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1001583000683 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001583000684 Walker A/P-loop; other site 1001583000685 ATP binding site [chemical binding]; other site 1001583000686 Q-loop/lid; other site 1001583000687 ABC transporter signature motif; other site 1001583000688 Walker B; other site 1001583000689 D-loop; other site 1001583000690 H-loop/switch region; other site 1001583000691 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1001583000692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001583000693 ABC-ATPase subunit interface; other site 1001583000694 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1001583000695 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1001583000696 substrate binding site [chemical binding]; other site 1001583000697 THF binding site; other site 1001583000698 zinc-binding site [ion binding]; other site 1001583000699 Predicted flavoprotein [General function prediction only]; Region: COG0431 1001583000700 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1001583000701 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001583000702 MarR family; Region: MarR_2; pfam12802 1001583000703 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1001583000704 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1001583000705 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1001583000706 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1001583000707 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001583000708 motif II; other site 1001583000709 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1001583000710 Peptidase family C69; Region: Peptidase_C69; pfam03577 1001583000711 maltose O-acetyltransferase; Provisional; Region: PRK10092 1001583000712 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1001583000713 active site 1001583000714 substrate binding site [chemical binding]; other site 1001583000715 trimer interface [polypeptide binding]; other site 1001583000716 CoA binding site [chemical binding]; other site 1001583000717 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 1001583000718 EamA-like transporter family; Region: EamA; pfam00892 1001583000719 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1001583000720 EamA-like transporter family; Region: EamA; pfam00892 1001583000721 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1001583000722 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1001583000723 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1001583000724 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 1001583000725 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1001583000726 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1001583000727 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1001583000728 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1001583000729 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1001583000730 active site 1001583000731 catalytic tetrad [active] 1001583000732 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1001583000733 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1001583000734 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001583000735 motif II; other site 1001583000736 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1001583000737 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1001583000738 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1001583000739 putative active site [active] 1001583000740 putative metal binding site [ion binding]; other site 1001583000741 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1001583000742 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1001583000743 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1001583000744 active site 1001583000745 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1001583000746 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1001583000747 catalytic triad [active] 1001583000748 oxyanion hole [active] 1001583000749 catalytic triad [active] 1001583000750 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1001583000751 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1001583000752 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1001583000753 Catalytic site [active] 1001583000754 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1001583000755 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1001583000756 active site 1001583000757 catalytic motif [active] 1001583000758 Zn binding site [ion binding]; other site 1001583000759 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001583000760 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1001583000761 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1001583000762 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1001583000763 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 1001583000764 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001583000765 Walker A/P-loop; other site 1001583000766 ATP binding site [chemical binding]; other site 1001583000767 Q-loop/lid; other site 1001583000768 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001583000769 ABC transporter signature motif; other site 1001583000770 Walker B; other site 1001583000771 D-loop; other site 1001583000772 H-loop/switch region; other site 1001583000773 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001583000774 AAA domain; Region: AAA_21; pfam13304 1001583000775 Walker A/P-loop; other site 1001583000776 ATP binding site [chemical binding]; other site 1001583000777 Q-loop/lid; other site 1001583000778 ABC transporter signature motif; other site 1001583000779 Walker B; other site 1001583000780 D-loop; other site 1001583000781 H-loop/switch region; other site 1001583000782 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1001583000783 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001583000784 dimer interface [polypeptide binding]; other site 1001583000785 conserved gate region; other site 1001583000786 putative PBP binding loops; other site 1001583000787 ABC-ATPase subunit interface; other site 1001583000788 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1001583000789 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1001583000790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001583000791 dimer interface [polypeptide binding]; other site 1001583000792 conserved gate region; other site 1001583000793 putative PBP binding loops; other site 1001583000794 ABC-ATPase subunit interface; other site 1001583000795 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1001583000796 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1001583000797 Walker A/P-loop; other site 1001583000798 ATP binding site [chemical binding]; other site 1001583000799 Q-loop/lid; other site 1001583000800 ABC transporter signature motif; other site 1001583000801 Walker B; other site 1001583000802 D-loop; other site 1001583000803 H-loop/switch region; other site 1001583000804 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1001583000805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001583000806 NAD(P) binding site [chemical binding]; other site 1001583000807 active site 1001583000808 drug efflux system protein MdtG; Provisional; Region: PRK09874 1001583000809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583000810 putative substrate translocation pore; other site 1001583000811 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1001583000812 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1001583000813 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1001583000814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001583000815 homodimer interface [polypeptide binding]; other site 1001583000816 catalytic residue [active] 1001583000817 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 1001583000818 conserved hypothetical integral membrane protein; Region: TIGR03766 1001583000819 conserved hypothetical integral membrane protein; Region: TIGR03766 1001583000820 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1001583000821 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1001583000822 Ligand binding site; other site 1001583000823 Putative Catalytic site; other site 1001583000824 DXD motif; other site 1001583000825 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 1001583000826 active site 1001583000827 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1001583000828 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1001583000829 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1001583000830 FtsX-like permease family; Region: FtsX; pfam02687 1001583000831 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1001583000832 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1001583000833 Walker A/P-loop; other site 1001583000834 ATP binding site [chemical binding]; other site 1001583000835 Q-loop/lid; other site 1001583000836 ABC transporter signature motif; other site 1001583000837 Walker B; other site 1001583000838 D-loop; other site 1001583000839 H-loop/switch region; other site 1001583000840 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1001583000841 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1001583000842 Ca binding site [ion binding]; other site 1001583000843 active site 1001583000844 catalytic site [active] 1001583000845 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1001583000846 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1001583000847 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1001583000848 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1001583000849 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1001583000850 Cl binding site [ion binding]; other site 1001583000851 oligomer interface [polypeptide binding]; other site 1001583000852 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 1001583000853 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1001583000854 PYR/PP interface [polypeptide binding]; other site 1001583000855 tetramer interface [polypeptide binding]; other site 1001583000856 dimer interface [polypeptide binding]; other site 1001583000857 TPP binding site [chemical binding]; other site 1001583000858 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1001583000859 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1001583000860 TPP-binding site [chemical binding]; other site 1001583000861 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1001583000862 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1001583000863 dimer interface [polypeptide binding]; other site 1001583000864 phosphorylation site [posttranslational modification] 1001583000865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001583000866 ATP binding site [chemical binding]; other site 1001583000867 Mg2+ binding site [ion binding]; other site 1001583000868 G-X-G motif; other site 1001583000869 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1001583000870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001583000871 active site 1001583000872 phosphorylation site [posttranslational modification] 1001583000873 intermolecular recognition site; other site 1001583000874 dimerization interface [polypeptide binding]; other site 1001583000875 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1001583000876 DNA binding site [nucleotide binding] 1001583000877 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1001583000878 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1001583000879 NAD(P) binding site [chemical binding]; other site 1001583000880 putative active site [active] 1001583000881 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1001583000882 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1001583000883 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001583000884 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1001583000885 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1001583000886 DNA binding site [nucleotide binding] 1001583000887 active site 1001583000888 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001583000889 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1001583000890 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1001583000891 NAD(P) binding site [chemical binding]; other site 1001583000892 catalytic residues [active] 1001583000893 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1001583000894 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1001583000895 Bacterial transcriptional regulator; Region: IclR; pfam01614 1001583000896 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1001583000897 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1001583000898 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 1001583000899 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1001583000900 NADP binding site [chemical binding]; other site 1001583000901 homodimer interface [polypeptide binding]; other site 1001583000902 active site 1001583000903 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 1001583000904 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1001583000905 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1001583000906 substrate binding site [chemical binding]; other site 1001583000907 ATP binding site [chemical binding]; other site 1001583000908 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1001583000909 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1001583000910 active site 1001583000911 intersubunit interface [polypeptide binding]; other site 1001583000912 catalytic residue [active] 1001583000913 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1001583000914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001583000915 NAD(P) binding site [chemical binding]; other site 1001583000916 active site 1001583000917 manganese transport protein MntH; Reviewed; Region: PRK00701 1001583000918 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1001583000919 EDD domain protein, DegV family; Region: DegV; TIGR00762 1001583000920 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1001583000921 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1001583000922 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1001583000923 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001583000924 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1001583000925 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1001583000926 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1001583000927 catalytic residues [active] 1001583000928 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1001583000929 putative homodimer interface [polypeptide binding]; other site 1001583000930 putative homotetramer interface [polypeptide binding]; other site 1001583000931 putative metal binding site [ion binding]; other site 1001583000932 putative homodimer-homodimer interface [polypeptide binding]; other site 1001583000933 putative allosteric switch controlling residues; other site 1001583000934 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1001583000935 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1001583000936 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 1001583000937 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1001583000938 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1001583000939 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1001583000940 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1001583000941 FAD binding pocket [chemical binding]; other site 1001583000942 conserved FAD binding motif [chemical binding]; other site 1001583000943 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1001583000944 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1001583000945 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1001583000946 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1001583000947 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001583000948 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1001583000949 dimerization interface [polypeptide binding]; other site 1001583000950 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1001583000951 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 1001583000952 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 1001583000953 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1001583000954 homotetramer interface [polypeptide binding]; other site 1001583000955 NAD binding site [chemical binding]; other site 1001583000956 homodimer interface [polypeptide binding]; other site 1001583000957 active site 1001583000958 drug efflux system protein MdtG; Provisional; Region: PRK09874 1001583000959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583000960 putative substrate translocation pore; other site 1001583000961 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1001583000962 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1001583000963 synthetase active site [active] 1001583000964 metal binding site [ion binding]; metal-binding site 1001583000965 NTP binding site [chemical binding]; other site 1001583000966 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1001583000967 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1001583000968 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1001583000969 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1001583000970 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1001583000971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001583000972 active site 1001583000973 phosphorylation site [posttranslational modification] 1001583000974 intermolecular recognition site; other site 1001583000975 dimerization interface [polypeptide binding]; other site 1001583000976 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1001583000977 DNA binding site [nucleotide binding] 1001583000978 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1001583000979 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1001583000980 dimer interface [polypeptide binding]; other site 1001583000981 phosphorylation site [posttranslational modification] 1001583000982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001583000983 ATP binding site [chemical binding]; other site 1001583000984 Mg2+ binding site [ion binding]; other site 1001583000985 G-X-G motif; other site 1001583000986 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1001583000987 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1001583000988 DNA binding site [nucleotide binding] 1001583000989 domain linker motif; other site 1001583000990 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1001583000991 putative dimerization interface [polypeptide binding]; other site 1001583000992 putative ligand binding site [chemical binding]; other site 1001583000993 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 1001583000994 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001583000995 maltose phosphorylase; Provisional; Region: PRK13807 1001583000996 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1001583000997 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1001583000998 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1001583000999 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1001583001000 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1001583001001 active site 1001583001002 catalytic residues [active] 1001583001003 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1001583001004 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1001583001005 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1001583001006 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1001583001007 MarR family; Region: MarR_2; pfam12802 1001583001008 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1001583001009 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1001583001010 putative catalytic residues [active] 1001583001011 thiol/disulfide switch; other site 1001583001012 ArsC family; Region: ArsC; pfam03960 1001583001013 NlpC/P60 family; Region: NLPC_P60; pfam00877 1001583001014 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1001583001015 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 1001583001016 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1001583001017 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001583001018 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001583001019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583001020 putative substrate translocation pore; other site 1001583001021 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1001583001022 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1001583001023 inhibitor binding site; inhibition site 1001583001024 active site 1001583001025 Cupin domain; Region: Cupin_2; pfam07883 1001583001026 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1001583001027 Helix-turn-helix domain; Region: HTH_18; pfam12833 1001583001028 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1001583001029 classical (c) SDRs; Region: SDR_c; cd05233 1001583001030 NAD(P) binding site [chemical binding]; other site 1001583001031 active site 1001583001032 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1001583001033 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001583001034 NAD(P) binding site [chemical binding]; other site 1001583001035 active site 1001583001036 Predicted transcriptional regulator [Transcription]; Region: COG1959 1001583001037 Transcriptional regulator; Region: Rrf2; pfam02082 1001583001038 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1001583001039 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1001583001040 Predicted transcriptional regulators [Transcription]; Region: COG1733 1001583001041 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001583001042 putative DNA binding site [nucleotide binding]; other site 1001583001043 putative Zn2+ binding site [ion binding]; other site 1001583001044 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1001583001045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583001046 putative substrate translocation pore; other site 1001583001047 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1001583001048 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1001583001049 active site 1001583001050 catalytic tetrad [active] 1001583001051 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1001583001052 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1001583001053 Walker A/P-loop; other site 1001583001054 ATP binding site [chemical binding]; other site 1001583001055 Q-loop/lid; other site 1001583001056 ABC transporter signature motif; other site 1001583001057 Walker B; other site 1001583001058 D-loop; other site 1001583001059 H-loop/switch region; other site 1001583001060 Predicted transcriptional regulators [Transcription]; Region: COG1725 1001583001061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001583001062 DNA-binding site [nucleotide binding]; DNA binding site 1001583001063 Collagen binding domain; Region: Collagen_bind; pfam05737 1001583001064 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1001583001065 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1001583001066 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1001583001067 multicopper oxidase; Provisional; Region: PRK10965 1001583001068 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1001583001069 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1001583001070 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001583001071 dimerization interface [polypeptide binding]; other site 1001583001072 putative DNA binding site [nucleotide binding]; other site 1001583001073 putative Zn2+ binding site [ion binding]; other site 1001583001074 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 1001583001075 Cadmium resistance transporter; Region: Cad; pfam03596 1001583001076 Predicted membrane protein [Function unknown]; Region: COG2855 1001583001077 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1001583001078 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001583001079 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1001583001080 dimerization interface [polypeptide binding]; other site 1001583001081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583001082 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001583001083 putative substrate translocation pore; other site 1001583001084 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1001583001085 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1001583001086 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1001583001087 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1001583001088 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1001583001089 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1001583001090 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1001583001091 ABC transporter; Region: ABC_tran_2; pfam12848 1001583001092 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1001583001093 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1001583001094 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1001583001095 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 1001583001096 active site 1001583001097 dimerization interface [polypeptide binding]; other site 1001583001098 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1001583001099 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1001583001100 B3/4 domain; Region: B3_4; pfam03483 1001583001101 Protein of unknown function (DUF975); Region: DUF975; cl10504 1001583001102 Predicted transcriptional regulators [Transcription]; Region: COG1725 1001583001103 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001583001104 DNA-binding site [nucleotide binding]; DNA binding site 1001583001105 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1001583001106 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1001583001107 Walker A/P-loop; other site 1001583001108 ATP binding site [chemical binding]; other site 1001583001109 Q-loop/lid; other site 1001583001110 ABC transporter signature motif; other site 1001583001111 Walker B; other site 1001583001112 D-loop; other site 1001583001113 H-loop/switch region; other site 1001583001114 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1001583001115 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1001583001116 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1001583001117 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1001583001118 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1001583001119 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1001583001120 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1001583001121 Predicted membrane protein [Function unknown]; Region: COG3428 1001583001122 Bacterial PH domain; Region: DUF304; pfam03703 1001583001123 Bacterial PH domain; Region: DUF304; pfam03703 1001583001124 Bacterial PH domain; Region: DUF304; pfam03703 1001583001125 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1001583001126 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1001583001127 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1001583001128 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1001583001129 Na binding site [ion binding]; other site 1001583001130 Mga helix-turn-helix domain; Region: Mga; pfam05043 1001583001131 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1001583001132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1001583001133 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1001583001134 MarR family; Region: MarR_2; pfam12802 1001583001135 manganese transport protein MntH; Reviewed; Region: PRK00701 1001583001136 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1001583001137 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1001583001138 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1001583001139 active site 1001583001140 HIGH motif; other site 1001583001141 dimer interface [polypeptide binding]; other site 1001583001142 KMSKS motif; other site 1001583001143 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1001583001144 RNA binding surface [nucleotide binding]; other site 1001583001145 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1001583001146 nudix motif; other site 1001583001147 Predicted membrane protein [Function unknown]; Region: COG2323 1001583001148 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 1001583001149 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1001583001150 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001583001151 non-specific DNA binding site [nucleotide binding]; other site 1001583001152 salt bridge; other site 1001583001153 sequence-specific DNA binding site [nucleotide binding]; other site 1001583001154 H+ Antiporter protein; Region: 2A0121; TIGR00900 1001583001155 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1001583001156 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001583001157 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1001583001158 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1001583001159 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1001583001160 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1001583001161 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1001583001162 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1001583001163 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1001583001164 substrate binding site [chemical binding]; other site 1001583001165 ATP binding site [chemical binding]; other site 1001583001166 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1001583001167 active site 1001583001168 dimer interface [polypeptide binding]; other site 1001583001169 magnesium binding site [ion binding]; other site 1001583001170 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1001583001171 tetramer interface [polypeptide binding]; other site 1001583001172 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1001583001173 active site 1001583001174 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1001583001175 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1001583001176 DNA binding site [nucleotide binding] 1001583001177 domain linker motif; other site 1001583001178 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1001583001179 putative dimerization interface [polypeptide binding]; other site 1001583001180 putative ligand binding site [chemical binding]; other site 1001583001181 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1001583001182 Part of AAA domain; Region: AAA_19; pfam13245 1001583001183 Family description; Region: UvrD_C_2; pfam13538 1001583001184 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1001583001185 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1001583001186 active site 1001583001187 HIGH motif; other site 1001583001188 dimer interface [polypeptide binding]; other site 1001583001189 KMSKS motif; other site 1001583001190 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1001583001191 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1001583001192 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1001583001193 homodimer interface [polypeptide binding]; other site 1001583001194 catalytic residues [active] 1001583001195 NAD binding site [chemical binding]; other site 1001583001196 substrate binding pocket [chemical binding]; other site 1001583001197 flexible flap; other site 1001583001198 NAD-dependent deacetylase; Provisional; Region: PRK00481 1001583001199 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 1001583001200 NAD+ binding site [chemical binding]; other site 1001583001201 substrate binding site [chemical binding]; other site 1001583001202 putative Zn binding site [ion binding]; other site 1001583001203 Protein of unknown function DUF72; Region: DUF72; pfam01904 1001583001204 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1001583001205 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1001583001206 active site 1001583001207 HIGH motif; other site 1001583001208 KMSKS motif; other site 1001583001209 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1001583001210 tRNA binding surface [nucleotide binding]; other site 1001583001211 anticodon binding site; other site 1001583001212 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1001583001213 dimer interface [polypeptide binding]; other site 1001583001214 putative tRNA-binding site [nucleotide binding]; other site 1001583001215 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1001583001216 active site 1001583001217 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1001583001218 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1001583001219 putative active site [active] 1001583001220 putative metal binding site [ion binding]; other site 1001583001221 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1001583001222 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1001583001223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001583001224 S-adenosylmethionine binding site [chemical binding]; other site 1001583001225 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1001583001226 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1001583001227 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1001583001228 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 1001583001229 putative uracil binding site [chemical binding]; other site 1001583001230 putative active site [active] 1001583001231 putative alpha-glucosidase; Provisional; Region: PRK10658 1001583001232 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1001583001233 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 1001583001234 active site 1001583001235 homotrimer interface [polypeptide binding]; other site 1001583001236 catalytic site [active] 1001583001237 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 1001583001238 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1001583001239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583001240 MarR family; Region: MarR_2; pfam12802 1001583001241 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1001583001242 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1001583001243 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1001583001244 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1001583001245 beta-galactosidase; Region: BGL; TIGR03356 1001583001246 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1001583001247 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1001583001248 nucleotide binding site [chemical binding]; other site 1001583001249 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1001583001250 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1001583001251 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1001583001252 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1001583001253 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1001583001254 intersubunit interface [polypeptide binding]; other site 1001583001255 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1001583001256 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1001583001257 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1001583001258 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1001583001259 putative PBP binding regions; other site 1001583001260 ABC-ATPase subunit interface; other site 1001583001261 pur operon repressor; Provisional; Region: PRK09213 1001583001262 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1001583001263 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001583001264 active site 1001583001265 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1001583001266 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1001583001267 Substrate binding site; other site 1001583001268 Mg++ binding site; other site 1001583001269 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1001583001270 active site 1001583001271 substrate binding site [chemical binding]; other site 1001583001272 CoA binding site [chemical binding]; other site 1001583001273 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1001583001274 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1001583001275 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001583001276 active site 1001583001277 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 1001583001278 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1001583001279 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1001583001280 DNA binding residues [nucleotide binding] 1001583001281 dimer interface [polypeptide binding]; other site 1001583001282 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001583001283 DNA-binding site [nucleotide binding]; DNA binding site 1001583001284 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1001583001285 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1001583001286 putative phosphoketolase; Provisional; Region: PRK05261 1001583001287 XFP N-terminal domain; Region: XFP_N; pfam09364 1001583001288 XFP C-terminal domain; Region: XFP_C; pfam09363 1001583001289 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1001583001290 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1001583001291 sugar phosphate phosphatase; Provisional; Region: PRK10513 1001583001292 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001583001293 active site 1001583001294 motif I; other site 1001583001295 motif II; other site 1001583001296 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1001583001297 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1001583001298 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1001583001299 Zn2+ binding site [ion binding]; other site 1001583001300 Mg2+ binding site [ion binding]; other site 1001583001301 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1001583001302 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1001583001303 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1001583001304 CTP synthetase; Validated; Region: pyrG; PRK05380 1001583001305 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1001583001306 Catalytic site [active] 1001583001307 active site 1001583001308 UTP binding site [chemical binding]; other site 1001583001309 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1001583001310 active site 1001583001311 putative oxyanion hole; other site 1001583001312 catalytic triad [active] 1001583001313 legume lectins; Region: lectin_L-type; cl14058 1001583001314 homotetramer interaction site [polypeptide binding]; other site 1001583001315 carbohydrate binding site [chemical binding]; other site 1001583001316 metal binding site [ion binding]; metal-binding site 1001583001317 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001583001318 MarR family; Region: MarR_2; pfam12802 1001583001319 acetolactate synthase; Reviewed; Region: PRK08617 1001583001320 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1001583001321 PYR/PP interface [polypeptide binding]; other site 1001583001322 dimer interface [polypeptide binding]; other site 1001583001323 TPP binding site [chemical binding]; other site 1001583001324 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1001583001325 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1001583001326 TPP-binding site [chemical binding]; other site 1001583001327 dimer interface [polypeptide binding]; other site 1001583001328 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1001583001329 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1001583001330 MucBP domain; Region: MucBP; pfam06458 1001583001331 MucBP domain; Region: MucBP; pfam06458 1001583001332 MucBP domain; Region: MucBP; pfam06458 1001583001333 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1001583001334 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1001583001335 hinge; other site 1001583001336 active site 1001583001337 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1001583001338 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1001583001339 active site 1001583001340 catalytic site [active] 1001583001341 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1001583001342 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1001583001343 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583001344 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583001345 Integrase core domain; Region: rve; pfam00665 1001583001346 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1001583001347 legume lectins; Region: lectin_L-type; cl14058 1001583001348 carbohydrate binding site [chemical binding]; other site 1001583001349 metal binding site [ion binding]; metal-binding site 1001583001350 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1001583001351 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1001583001352 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1001583001353 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1001583001354 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1001583001355 legume lectins; Region: lectin_L-type; cl14058 1001583001356 homotetramer interaction site [polypeptide binding]; other site 1001583001357 carbohydrate binding site [chemical binding]; other site 1001583001358 metal binding site [ion binding]; metal-binding site 1001583001359 legume lectins; Region: lectin_L-type; cl14058 1001583001360 homotetramer interaction site [polypeptide binding]; other site 1001583001361 carbohydrate binding site [chemical binding]; other site 1001583001362 metal binding site [ion binding]; metal-binding site 1001583001363 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1001583001364 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1001583001365 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1001583001366 active site 1001583001367 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1001583001368 heat shock protein HtpX; Provisional; Region: PRK04897 1001583001369 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1001583001370 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1001583001371 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1001583001372 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1001583001373 helicase 45; Provisional; Region: PTZ00424 1001583001374 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1001583001375 ATP binding site [chemical binding]; other site 1001583001376 Mg++ binding site [ion binding]; other site 1001583001377 motif III; other site 1001583001378 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001583001379 nucleotide binding region [chemical binding]; other site 1001583001380 ATP-binding site [chemical binding]; other site 1001583001381 Muconolactone delta-isomerase; Region: MIase; cl01992 1001583001382 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1001583001383 alanine racemase; Reviewed; Region: alr; PRK00053 1001583001384 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1001583001385 active site 1001583001386 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1001583001387 dimer interface [polypeptide binding]; other site 1001583001388 substrate binding site [chemical binding]; other site 1001583001389 catalytic residues [active] 1001583001390 PemK-like protein; Region: PemK; pfam02452 1001583001391 FOG: CBS domain [General function prediction only]; Region: COG0517 1001583001392 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1001583001393 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1001583001394 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1001583001395 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1001583001396 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1001583001397 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1001583001398 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1001583001399 NAD binding site [chemical binding]; other site 1001583001400 dimer interface [polypeptide binding]; other site 1001583001401 substrate binding site [chemical binding]; other site 1001583001402 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1001583001403 putative active site [active] 1001583001404 catalytic residue [active] 1001583001405 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1001583001406 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1001583001407 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1001583001408 ATP binding site [chemical binding]; other site 1001583001409 putative Mg++ binding site [ion binding]; other site 1001583001410 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001583001411 nucleotide binding region [chemical binding]; other site 1001583001412 ATP-binding site [chemical binding]; other site 1001583001413 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1001583001414 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1001583001415 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1001583001416 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1001583001417 RNA binding surface [nucleotide binding]; other site 1001583001418 Septum formation initiator; Region: DivIC; pfam04977 1001583001419 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1001583001420 hypothetical protein; Provisional; Region: PRK08582 1001583001421 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1001583001422 RNA binding site [nucleotide binding]; other site 1001583001423 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1001583001424 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1001583001425 Ligand Binding Site [chemical binding]; other site 1001583001426 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1001583001427 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001583001428 active site 1001583001429 FtsH Extracellular; Region: FtsH_ext; pfam06480 1001583001430 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1001583001431 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001583001432 Walker A motif; other site 1001583001433 ATP binding site [chemical binding]; other site 1001583001434 Walker B motif; other site 1001583001435 arginine finger; other site 1001583001436 Peptidase family M41; Region: Peptidase_M41; pfam01434 1001583001437 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1001583001438 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1001583001439 dimerization interface [polypeptide binding]; other site 1001583001440 domain crossover interface; other site 1001583001441 redox-dependent activation switch; other site 1001583001442 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1001583001443 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1001583001444 FMN binding site [chemical binding]; other site 1001583001445 active site 1001583001446 catalytic residues [active] 1001583001447 substrate binding site [chemical binding]; other site 1001583001448 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1001583001449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583001450 putative substrate translocation pore; other site 1001583001451 POT family; Region: PTR2; cl17359 1001583001452 putative phosphoesterase; Region: acc_ester; TIGR03729 1001583001453 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1001583001454 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1001583001455 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1001583001456 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1001583001457 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1001583001458 active site 1001583001459 dimer interface [polypeptide binding]; other site 1001583001460 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1001583001461 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001583001462 DNA-binding site [nucleotide binding]; DNA binding site 1001583001463 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1001583001464 putative acetyltransferase; Provisional; Region: PRK03624 1001583001465 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001583001466 Coenzyme A binding pocket [chemical binding]; other site 1001583001467 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1001583001468 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1001583001469 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1001583001470 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1001583001471 active site 1001583001472 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1001583001473 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1001583001474 homodimer interface [polypeptide binding]; other site 1001583001475 NAD binding pocket [chemical binding]; other site 1001583001476 ATP binding pocket [chemical binding]; other site 1001583001477 Mg binding site [ion binding]; other site 1001583001478 active-site loop [active] 1001583001479 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1001583001480 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1001583001481 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1001583001482 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1001583001483 RNA binding site [nucleotide binding]; other site 1001583001484 hypothetical protein; Provisional; Region: PRK04351 1001583001485 SprT homologues; Region: SprT; cl01182 1001583001486 homoserine kinase; Provisional; Region: PRK01212 1001583001487 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1001583001488 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1001583001489 Amidohydrolase; Region: Amidohydro_2; pfam04909 1001583001490 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1001583001491 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001583001492 Predicted membrane protein [Function unknown]; Region: COG2364 1001583001493 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001583001494 MarR family; Region: MarR_2; pfam12802 1001583001495 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1001583001496 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1001583001497 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1001583001498 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001583001499 active site 1001583001500 motif I; other site 1001583001501 motif II; other site 1001583001502 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1001583001503 active pocket/dimerization site; other site 1001583001504 active site 1001583001505 phosphorylation site [posttranslational modification] 1001583001506 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 1001583001507 active site 1001583001508 phosphorylation site [posttranslational modification] 1001583001509 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1001583001510 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1001583001511 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1001583001512 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1001583001513 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1001583001514 metal binding site [ion binding]; metal-binding site 1001583001515 active site 1001583001516 I-site; other site 1001583001517 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1001583001518 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001583001519 Predicted membrane protein [Function unknown]; Region: COG1511 1001583001520 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1001583001521 Predicted membrane protein [Function unknown]; Region: COG1511 1001583001522 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1001583001523 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1001583001524 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 1001583001525 metal binding site [ion binding]; metal-binding site 1001583001526 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1001583001527 Membrane transport protein; Region: Mem_trans; pfam03547 1001583001528 EamA-like transporter family; Region: EamA; pfam00892 1001583001529 EamA-like transporter family; Region: EamA; pfam00892 1001583001530 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1001583001531 catalytic core [active] 1001583001532 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1001583001533 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1001583001534 Beta-lactamase; Region: Beta-lactamase; pfam00144 1001583001535 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1001583001536 trimer interface [polypeptide binding]; other site 1001583001537 active site 1001583001538 G bulge; other site 1001583001539 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583001540 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583001541 Integrase core domain; Region: rve; pfam00665 1001583001542 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1001583001543 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1001583001544 active site 1001583001545 dimer interface [polypeptide binding]; other site 1001583001546 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1001583001547 trimer interface [polypeptide binding]; other site 1001583001548 active site 1001583001549 DNA repair protein RadA; Provisional; Region: PRK11823 1001583001550 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1001583001551 Walker A motif/ATP binding site; other site 1001583001552 ATP binding site [chemical binding]; other site 1001583001553 Walker B motif; other site 1001583001554 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1001583001555 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1001583001556 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1001583001557 putative active site [active] 1001583001558 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1001583001559 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1001583001560 active site 1001583001561 HIGH motif; other site 1001583001562 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1001583001563 active site 1001583001564 KMSKS motif; other site 1001583001565 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1001583001566 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1001583001567 active site 1001583001568 HIGH motif; other site 1001583001569 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1001583001570 KMSKS motif; other site 1001583001571 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1001583001572 tRNA binding surface [nucleotide binding]; other site 1001583001573 anticodon binding site; other site 1001583001574 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1001583001575 active site 1001583001576 metal binding site [ion binding]; metal-binding site 1001583001577 dimerization interface [polypeptide binding]; other site 1001583001578 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1001583001579 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1001583001580 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1001583001581 YacP-like NYN domain; Region: NYN_YacP; pfam05991 1001583001582 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1001583001583 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1001583001584 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1001583001585 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1001583001586 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1001583001587 putative homodimer interface [polypeptide binding]; other site 1001583001588 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1001583001589 heterodimer interface [polypeptide binding]; other site 1001583001590 homodimer interface [polypeptide binding]; other site 1001583001591 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1001583001592 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1001583001593 putative thiostrepton binding site; other site 1001583001594 23S rRNA interface [nucleotide binding]; other site 1001583001595 L7/L12 interface [polypeptide binding]; other site 1001583001596 L25 interface [polypeptide binding]; other site 1001583001597 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1001583001598 mRNA/rRNA interface [nucleotide binding]; other site 1001583001599 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1001583001600 23S rRNA interface [nucleotide binding]; other site 1001583001601 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1001583001602 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1001583001603 peripheral dimer interface [polypeptide binding]; other site 1001583001604 core dimer interface [polypeptide binding]; other site 1001583001605 L10 interface [polypeptide binding]; other site 1001583001606 L11 interface [polypeptide binding]; other site 1001583001607 putative EF-Tu interaction site [polypeptide binding]; other site 1001583001608 putative EF-G interaction site [polypeptide binding]; other site 1001583001609 Predicted integral membrane protein [Function unknown]; Region: COG0392 1001583001610 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1001583001611 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1001583001612 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1001583001613 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 1001583001614 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1001583001615 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1001583001616 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1001583001617 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1001583001618 dimer interface [polypeptide binding]; other site 1001583001619 putative radical transfer pathway; other site 1001583001620 diiron center [ion binding]; other site 1001583001621 tyrosyl radical; other site 1001583001622 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 1001583001623 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1001583001624 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1001583001625 active site 1001583001626 dimer interface [polypeptide binding]; other site 1001583001627 catalytic residues [active] 1001583001628 effector binding site; other site 1001583001629 R2 peptide binding site; other site 1001583001630 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1001583001631 catalytic residues [active] 1001583001632 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1001583001633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001583001634 S-adenosylmethionine binding site [chemical binding]; other site 1001583001635 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1001583001636 nucleoside/Zn binding site; other site 1001583001637 dimer interface [polypeptide binding]; other site 1001583001638 catalytic motif [active] 1001583001639 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1001583001640 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001583001641 Walker A motif; other site 1001583001642 ATP binding site [chemical binding]; other site 1001583001643 Walker B motif; other site 1001583001644 arginine finger; other site 1001583001645 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1001583001646 hypothetical protein; Validated; Region: PRK00153 1001583001647 recombination protein RecR; Reviewed; Region: recR; PRK00076 1001583001648 RecR protein; Region: RecR; pfam02132 1001583001649 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1001583001650 putative active site [active] 1001583001651 putative metal-binding site [ion binding]; other site 1001583001652 tetramer interface [polypeptide binding]; other site 1001583001653 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1001583001654 thymidylate kinase; Validated; Region: tmk; PRK00698 1001583001655 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1001583001656 TMP-binding site; other site 1001583001657 ATP-binding site [chemical binding]; other site 1001583001658 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1001583001659 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1001583001660 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1001583001661 Protein of unknown function (DUF972); Region: DUF972; pfam06156 1001583001662 Predicted methyltransferases [General function prediction only]; Region: COG0313 1001583001663 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1001583001664 putative SAM binding site [chemical binding]; other site 1001583001665 putative homodimer interface [polypeptide binding]; other site 1001583001666 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 1001583001667 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1001583001668 active site 1001583001669 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1001583001670 active site 2 [active] 1001583001671 active site 1 [active] 1001583001672 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1001583001673 Glycoprotease family; Region: Peptidase_M22; pfam00814 1001583001674 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1001583001675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001583001676 Coenzyme A binding pocket [chemical binding]; other site 1001583001677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1001583001678 UGMP family protein; Validated; Region: PRK09604 1001583001679 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1001583001680 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1001583001681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583001682 putative substrate translocation pore; other site 1001583001683 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001583001684 dimerization interface [polypeptide binding]; other site 1001583001685 putative DNA binding site [nucleotide binding]; other site 1001583001686 putative Zn2+ binding site [ion binding]; other site 1001583001687 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1001583001688 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1001583001689 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1001583001690 ABC transporter; Region: ABC_tran_2; pfam12848 1001583001691 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1001583001692 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1001583001693 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1001583001694 CoA binding domain; Region: CoA_binding; pfam02629 1001583001695 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1001583001696 oligomerisation interface [polypeptide binding]; other site 1001583001697 mobile loop; other site 1001583001698 roof hairpin; other site 1001583001699 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1001583001700 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1001583001701 ring oligomerisation interface [polypeptide binding]; other site 1001583001702 ATP/Mg binding site [chemical binding]; other site 1001583001703 stacking interactions; other site 1001583001704 hinge regions; other site 1001583001705 Amino acid permease; Region: AA_permease_2; pfam13520 1001583001706 LrgB-like family; Region: LrgB; cl00596 1001583001707 LrgA family; Region: LrgA; cl00608 1001583001708 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1001583001709 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1001583001710 Mg++ binding site [ion binding]; other site 1001583001711 putative catalytic motif [active] 1001583001712 substrate binding site [chemical binding]; other site 1001583001713 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1001583001714 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1001583001715 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1001583001716 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1001583001717 ATP binding site [chemical binding]; other site 1001583001718 putative Mg++ binding site [ion binding]; other site 1001583001719 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001583001720 nucleotide binding region [chemical binding]; other site 1001583001721 ATP-binding site [chemical binding]; other site 1001583001722 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1001583001723 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001583001724 active site 1001583001725 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1001583001726 30S subunit binding site; other site 1001583001727 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 1001583001728 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1001583001729 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1001583001730 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001583001731 nucleotide binding region [chemical binding]; other site 1001583001732 ATP-binding site [chemical binding]; other site 1001583001733 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1001583001734 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1001583001735 RF-1 domain; Region: RF-1; pfam00472 1001583001736 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1001583001737 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1001583001738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001583001739 active site 1001583001740 phosphorylation site [posttranslational modification] 1001583001741 intermolecular recognition site; other site 1001583001742 dimerization interface [polypeptide binding]; other site 1001583001743 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1001583001744 DNA binding site [nucleotide binding] 1001583001745 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1001583001746 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1001583001747 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1001583001748 dimer interface [polypeptide binding]; other site 1001583001749 phosphorylation site [posttranslational modification] 1001583001750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001583001751 ATP binding site [chemical binding]; other site 1001583001752 Mg2+ binding site [ion binding]; other site 1001583001753 G-X-G motif; other site 1001583001754 PBP superfamily domain; Region: PBP_like_2; cl17296 1001583001755 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1001583001756 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1001583001757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001583001758 dimer interface [polypeptide binding]; other site 1001583001759 conserved gate region; other site 1001583001760 putative PBP binding loops; other site 1001583001761 ABC-ATPase subunit interface; other site 1001583001762 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1001583001763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001583001764 dimer interface [polypeptide binding]; other site 1001583001765 conserved gate region; other site 1001583001766 putative PBP binding loops; other site 1001583001767 ABC-ATPase subunit interface; other site 1001583001768 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 1001583001769 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1001583001770 Walker A/P-loop; other site 1001583001771 ATP binding site [chemical binding]; other site 1001583001772 Q-loop/lid; other site 1001583001773 ABC transporter signature motif; other site 1001583001774 Walker B; other site 1001583001775 D-loop; other site 1001583001776 H-loop/switch region; other site 1001583001777 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 1001583001778 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1001583001779 Walker A/P-loop; other site 1001583001780 ATP binding site [chemical binding]; other site 1001583001781 Q-loop/lid; other site 1001583001782 ABC transporter signature motif; other site 1001583001783 Walker B; other site 1001583001784 D-loop; other site 1001583001785 H-loop/switch region; other site 1001583001786 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1001583001787 PhoU domain; Region: PhoU; pfam01895 1001583001788 PhoU domain; Region: PhoU; pfam01895 1001583001789 PspC domain; Region: PspC; pfam04024 1001583001790 Membrane protein of unknown function; Region: DUF360; cl00850 1001583001791 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1001583001792 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1001583001793 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1001583001794 Hpr binding site; other site 1001583001795 active site 1001583001796 homohexamer subunit interaction site [polypeptide binding]; other site 1001583001797 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1001583001798 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1001583001799 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1001583001800 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1001583001801 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1001583001802 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1001583001803 active site 1001583001804 tetramer interface; other site 1001583001805 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1001583001806 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1001583001807 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001583001808 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1001583001809 Zn2+ binding site [ion binding]; other site 1001583001810 Mg2+ binding site [ion binding]; other site 1001583001811 excinuclease ABC subunit B; Provisional; Region: PRK05298 1001583001812 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1001583001813 ATP binding site [chemical binding]; other site 1001583001814 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001583001815 nucleotide binding region [chemical binding]; other site 1001583001816 ATP-binding site [chemical binding]; other site 1001583001817 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1001583001818 UvrB/uvrC motif; Region: UVR; pfam02151 1001583001819 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1001583001820 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1001583001821 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1001583001822 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1001583001823 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1001583001824 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1001583001825 shikimate kinase; Reviewed; Region: aroK; PRK00131 1001583001826 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1001583001827 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1001583001828 phosphate binding site [ion binding]; other site 1001583001829 putative substrate binding pocket [chemical binding]; other site 1001583001830 dimer interface [polypeptide binding]; other site 1001583001831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1001583001832 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1001583001833 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1001583001834 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1001583001835 oligomer interface [polypeptide binding]; other site 1001583001836 active site residues [active] 1001583001837 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1001583001838 LytTr DNA-binding domain; Region: LytTR; smart00850 1001583001839 Predicted membrane protein [Function unknown]; Region: COG4684 1001583001840 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1001583001841 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1001583001842 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1001583001843 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1001583001844 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1001583001845 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1001583001846 Phosphoglycerate kinase; Region: PGK; pfam00162 1001583001847 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1001583001848 substrate binding site [chemical binding]; other site 1001583001849 hinge regions; other site 1001583001850 ADP binding site [chemical binding]; other site 1001583001851 catalytic site [active] 1001583001852 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1001583001853 triosephosphate isomerase; Provisional; Region: PRK14567 1001583001854 substrate binding site [chemical binding]; other site 1001583001855 dimer interface [polypeptide binding]; other site 1001583001856 catalytic triad [active] 1001583001857 enolase; Provisional; Region: eno; PRK00077 1001583001858 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1001583001859 dimer interface [polypeptide binding]; other site 1001583001860 metal binding site [ion binding]; metal-binding site 1001583001861 substrate binding pocket [chemical binding]; other site 1001583001862 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1001583001863 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1001583001864 Cl- selectivity filter; other site 1001583001865 Cl- binding residues [ion binding]; other site 1001583001866 pore gating glutamate residue; other site 1001583001867 dimer interface [polypeptide binding]; other site 1001583001868 H+/Cl- coupling transport residue; other site 1001583001869 TrkA-C domain; Region: TrkA_C; pfam02080 1001583001870 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 1001583001871 Esterase/lipase [General function prediction only]; Region: COG1647 1001583001872 ribonuclease R; Region: RNase_R; TIGR02063 1001583001873 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1001583001874 RNB domain; Region: RNB; pfam00773 1001583001875 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1001583001876 RNA binding site [nucleotide binding]; other site 1001583001877 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1001583001878 SmpB-tmRNA interface; other site 1001583001879 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1001583001880 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1001583001881 Walker A/P-loop; other site 1001583001882 ATP binding site [chemical binding]; other site 1001583001883 Q-loop/lid; other site 1001583001884 ABC transporter signature motif; other site 1001583001885 Walker B; other site 1001583001886 D-loop; other site 1001583001887 H-loop/switch region; other site 1001583001888 Tubby C 2; Region: Tub_2; cl02043 1001583001889 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1001583001890 ligand binding site [chemical binding]; other site 1001583001891 active site 1001583001892 UGI interface [polypeptide binding]; other site 1001583001893 catalytic site [active] 1001583001894 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1001583001895 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1001583001896 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1001583001897 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001583001898 Coenzyme A binding pocket [chemical binding]; other site 1001583001899 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1001583001900 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1001583001901 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1001583001902 active site 1001583001903 catalytic tetrad [active] 1001583001904 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1001583001905 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1001583001906 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1001583001907 active site 1001583001908 catalytic site [active] 1001583001909 substrate binding site [chemical binding]; other site 1001583001910 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1001583001911 active site 1001583001912 putative catalytic site [active] 1001583001913 DNA binding site [nucleotide binding] 1001583001914 putative phosphate binding site [ion binding]; other site 1001583001915 metal binding site A [ion binding]; metal-binding site 1001583001916 AP binding site [nucleotide binding]; other site 1001583001917 metal binding site B [ion binding]; metal-binding site 1001583001918 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1001583001919 FAD binding domain; Region: FAD_binding_4; pfam01565 1001583001920 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1001583001921 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1001583001922 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1001583001923 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 1001583001924 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1001583001925 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1001583001926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1001583001927 YbbR-like protein; Region: YbbR; pfam07949 1001583001928 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1001583001929 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1001583001930 active site 1001583001931 substrate binding site [chemical binding]; other site 1001583001932 metal binding site [ion binding]; metal-binding site 1001583001933 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1001583001934 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1001583001935 glutaminase active site [active] 1001583001936 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1001583001937 dimer interface [polypeptide binding]; other site 1001583001938 active site 1001583001939 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1001583001940 dimer interface [polypeptide binding]; other site 1001583001941 active site 1001583001942 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1001583001943 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1001583001944 active site 1001583001945 trimer interface [polypeptide binding]; other site 1001583001946 allosteric site; other site 1001583001947 active site lid [active] 1001583001948 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1001583001949 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1001583001950 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1001583001951 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1001583001952 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1001583001953 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1001583001954 Ferritin-like domain; Region: Ferritin; pfam00210 1001583001955 dimerization interface [polypeptide binding]; other site 1001583001956 DPS ferroxidase diiron center [ion binding]; other site 1001583001957 ion pore; other site 1001583001958 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1001583001959 metal-binding site [ion binding] 1001583001960 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1001583001961 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1001583001962 Walker A/P-loop; other site 1001583001963 ATP binding site [chemical binding]; other site 1001583001964 Q-loop/lid; other site 1001583001965 ABC transporter signature motif; other site 1001583001966 Walker B; other site 1001583001967 D-loop; other site 1001583001968 H-loop/switch region; other site 1001583001969 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1001583001970 heme-binding site [chemical binding]; other site 1001583001971 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1001583001972 heme-binding site [chemical binding]; other site 1001583001973 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1001583001974 heme-binding site [chemical binding]; other site 1001583001975 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1001583001976 heme-binding site [chemical binding]; other site 1001583001977 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 1001583001978 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1001583001979 intersubunit interface [polypeptide binding]; other site 1001583001980 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1001583001981 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1001583001982 ABC-ATPase subunit interface; other site 1001583001983 dimer interface [polypeptide binding]; other site 1001583001984 putative PBP binding regions; other site 1001583001985 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1001583001986 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1001583001987 Walker A/P-loop; other site 1001583001988 ATP binding site [chemical binding]; other site 1001583001989 Q-loop/lid; other site 1001583001990 ABC transporter signature motif; other site 1001583001991 Walker B; other site 1001583001992 D-loop; other site 1001583001993 H-loop/switch region; other site 1001583001994 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1001583001995 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1001583001996 polyphosphate kinase; Provisional; Region: PRK05443 1001583001997 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1001583001998 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1001583001999 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1001583002000 putative domain interface [polypeptide binding]; other site 1001583002001 putative active site [active] 1001583002002 catalytic site [active] 1001583002003 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1001583002004 putative domain interface [polypeptide binding]; other site 1001583002005 putative active site [active] 1001583002006 catalytic site [active] 1001583002007 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1001583002008 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1001583002009 LicD family; Region: LicD; pfam04991 1001583002010 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1001583002011 MarR family; Region: MarR_2; pfam12802 1001583002012 OsmC-like protein; Region: OsmC; pfam02566 1001583002013 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1001583002014 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1001583002015 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1001583002016 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1001583002017 Class II fumarases; Region: Fumarase_classII; cd01362 1001583002018 active site 1001583002019 tetramer interface [polypeptide binding]; other site 1001583002020 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 1001583002021 hypothetical protein; Provisional; Region: PRK06446 1001583002022 metal binding site [ion binding]; metal-binding site 1001583002023 dimer interface [polypeptide binding]; other site 1001583002024 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1001583002025 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1001583002026 DNA binding site [nucleotide binding] 1001583002027 domain linker motif; other site 1001583002028 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1001583002029 dimerization interface [polypeptide binding]; other site 1001583002030 ligand binding site [chemical binding]; other site 1001583002031 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 1001583002032 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1001583002033 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1001583002034 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1001583002035 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1001583002036 active site 1001583002037 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583002038 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583002039 Integrase core domain; Region: rve; pfam00665 1001583002040 arginine deiminase; Provisional; Region: PRK01388 1001583002041 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1001583002042 Int/Topo IB signature motif; other site 1001583002043 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1001583002044 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001583002045 non-specific DNA binding site [nucleotide binding]; other site 1001583002046 salt bridge; other site 1001583002047 sequence-specific DNA binding site [nucleotide binding]; other site 1001583002048 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1001583002049 non-specific DNA binding site [nucleotide binding]; other site 1001583002050 salt bridge; other site 1001583002051 sequence-specific DNA binding site [nucleotide binding]; other site 1001583002052 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 1001583002053 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 1001583002054 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1001583002055 polymerase nucleotide-binding site; other site 1001583002056 DNA-binding residues [nucleotide binding]; DNA binding site 1001583002057 nucleotide binding site [chemical binding]; other site 1001583002058 primase nucleotide-binding site [nucleotide binding]; other site 1001583002059 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 1001583002060 Virulence-associated protein E; Region: VirE; pfam05272 1001583002061 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1001583002062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001583002063 active site 1001583002064 phosphorylation site [posttranslational modification] 1001583002065 intermolecular recognition site; other site 1001583002066 dimerization interface [polypeptide binding]; other site 1001583002067 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1001583002068 DNA binding site [nucleotide binding] 1001583002069 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1001583002070 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1001583002071 dimerization interface [polypeptide binding]; other site 1001583002072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1001583002073 dimer interface [polypeptide binding]; other site 1001583002074 phosphorylation site [posttranslational modification] 1001583002075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001583002076 ATP binding site [chemical binding]; other site 1001583002077 Mg2+ binding site [ion binding]; other site 1001583002078 G-X-G motif; other site 1001583002079 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1001583002080 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1001583002081 putative RNA binding site [nucleotide binding]; other site 1001583002082 Sugar transport protein; Region: Sugar_transport; pfam06800 1001583002083 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1001583002084 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1001583002085 active site 1001583002086 dimer interface [polypeptide binding]; other site 1001583002087 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1001583002088 dimer interface [polypeptide binding]; other site 1001583002089 active site 1001583002090 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1001583002091 TspO/MBR family; Region: TspO_MBR; pfam03073 1001583002092 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1001583002093 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 1001583002094 active site 1001583002095 conformational flexibility of ligand binding pocket; other site 1001583002096 ADP-ribosylating toxin turn-turn motif; other site 1001583002097 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1001583002098 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1001583002099 transmembrane helices; other site 1001583002100 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1001583002101 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583002102 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583002103 Integrase core domain; Region: rve; pfam00665 1001583002104 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1001583002105 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1001583002106 metal binding site [ion binding]; metal-binding site 1001583002107 active site 1001583002108 I-site; other site 1001583002109 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1001583002110 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1001583002111 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583002112 Integrase core domain; Region: rve; pfam00665 1001583002113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1001583002114 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1001583002115 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1001583002116 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583002117 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583002118 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1001583002119 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1001583002120 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001583002121 Walker A/P-loop; other site 1001583002122 ATP binding site [chemical binding]; other site 1001583002123 Q-loop/lid; other site 1001583002124 ABC transporter signature motif; other site 1001583002125 Walker B; other site 1001583002126 D-loop; other site 1001583002127 H-loop/switch region; other site 1001583002128 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1001583002129 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1001583002130 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1001583002131 Walker A/P-loop; other site 1001583002132 ATP binding site [chemical binding]; other site 1001583002133 Q-loop/lid; other site 1001583002134 ABC transporter signature motif; other site 1001583002135 Walker B; other site 1001583002136 D-loop; other site 1001583002137 H-loop/switch region; other site 1001583002138 Beta-lactamase; Region: Beta-lactamase; pfam00144 1001583002139 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1001583002140 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1001583002141 catalytic triad [active] 1001583002142 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1001583002143 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1001583002144 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1001583002145 thymidine kinase; Provisional; Region: PRK04296 1001583002146 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1001583002147 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1001583002148 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1001583002149 RF-1 domain; Region: RF-1; pfam00472 1001583002150 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1001583002151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001583002152 S-adenosylmethionine binding site [chemical binding]; other site 1001583002153 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1001583002154 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1001583002155 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1001583002156 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1001583002157 dimer interface [polypeptide binding]; other site 1001583002158 active site 1001583002159 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1001583002160 folate binding site [chemical binding]; other site 1001583002161 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001583002162 active site 1001583002163 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1001583002164 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1001583002165 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1001583002166 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1001583002167 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1001583002168 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1001583002169 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1001583002170 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1001583002171 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1001583002172 beta subunit interaction interface [polypeptide binding]; other site 1001583002173 Walker A motif; other site 1001583002174 ATP binding site [chemical binding]; other site 1001583002175 Walker B motif; other site 1001583002176 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1001583002177 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1001583002178 core domain interface [polypeptide binding]; other site 1001583002179 delta subunit interface [polypeptide binding]; other site 1001583002180 epsilon subunit interface [polypeptide binding]; other site 1001583002181 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1001583002182 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1001583002183 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1001583002184 alpha subunit interaction interface [polypeptide binding]; other site 1001583002185 Walker A motif; other site 1001583002186 ATP binding site [chemical binding]; other site 1001583002187 Walker B motif; other site 1001583002188 inhibitor binding site; inhibition site 1001583002189 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1001583002190 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1001583002191 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1001583002192 gamma subunit interface [polypeptide binding]; other site 1001583002193 epsilon subunit interface [polypeptide binding]; other site 1001583002194 LBP interface [polypeptide binding]; other site 1001583002195 Protein of unknown function (DUF1146); Region: DUF1146; pfam06612 1001583002196 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1001583002197 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1001583002198 hinge; other site 1001583002199 active site 1001583002200 rod shape-determining protein MreB; Provisional; Region: PRK13930 1001583002201 MreB and similar proteins; Region: MreB_like; cd10225 1001583002202 nucleotide binding site [chemical binding]; other site 1001583002203 Mg binding site [ion binding]; other site 1001583002204 putative protofilament interaction site [polypeptide binding]; other site 1001583002205 RodZ interaction site [polypeptide binding]; other site 1001583002206 Haemolytic domain; Region: Haemolytic; cl00506 1001583002207 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 1001583002208 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1001583002209 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1001583002210 lipoyl attachment site [posttranslational modification]; other site 1001583002211 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1001583002212 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1001583002213 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 1001583002214 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1001583002215 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1001583002216 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1001583002217 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1001583002218 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1001583002219 putative active site [active] 1001583002220 catalytic site [active] 1001583002221 putative metal binding site [ion binding]; other site 1001583002222 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1001583002223 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001583002224 non-specific DNA binding site [nucleotide binding]; other site 1001583002225 salt bridge; other site 1001583002226 sequence-specific DNA binding site [nucleotide binding]; other site 1001583002227 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1001583002228 Ligand Binding Site [chemical binding]; other site 1001583002229 recombination factor protein RarA; Reviewed; Region: PRK13342 1001583002230 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001583002231 Walker A motif; other site 1001583002232 ATP binding site [chemical binding]; other site 1001583002233 Walker B motif; other site 1001583002234 arginine finger; other site 1001583002235 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1001583002236 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1001583002237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1001583002238 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1001583002239 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1001583002240 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1001583002241 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1001583002242 RNA binding surface [nucleotide binding]; other site 1001583002243 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1001583002244 GAF domain; Region: GAF_2; pfam13185 1001583002245 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 1001583002246 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1001583002247 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1001583002248 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1001583002249 catalytic residue [active] 1001583002250 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1001583002251 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1001583002252 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1001583002253 Ligand Binding Site [chemical binding]; other site 1001583002254 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1001583002255 dimer interface [polypeptide binding]; other site 1001583002256 catalytic triad [active] 1001583002257 peroxidatic and resolving cysteines [active] 1001583002258 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1001583002259 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1001583002260 active site 1001583002261 HIGH motif; other site 1001583002262 nucleotide binding site [chemical binding]; other site 1001583002263 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1001583002264 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1001583002265 active site 1001583002266 KMSKS motif; other site 1001583002267 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1001583002268 tRNA binding surface [nucleotide binding]; other site 1001583002269 anticodon binding site; other site 1001583002270 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1001583002271 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1001583002272 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1001583002273 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1001583002274 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1001583002275 MPN+ (JAMM) motif; other site 1001583002276 Zinc-binding site [ion binding]; other site 1001583002277 rod shape-determining protein MreB; Provisional; Region: PRK13927 1001583002278 MreB and similar proteins; Region: MreB_like; cd10225 1001583002279 nucleotide binding site [chemical binding]; other site 1001583002280 Mg binding site [ion binding]; other site 1001583002281 putative protofilament interaction site [polypeptide binding]; other site 1001583002282 RodZ interaction site [polypeptide binding]; other site 1001583002283 rod shape-determining protein MreC; Provisional; Region: PRK13922 1001583002284 rod shape-determining protein MreC; Region: MreC; pfam04085 1001583002285 rod shape-determining protein MreD; Region: MreD; cl01087 1001583002286 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1001583002287 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1001583002288 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1001583002289 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1001583002290 Switch I; other site 1001583002291 Switch II; other site 1001583002292 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1001583002293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001583002294 dimer interface [polypeptide binding]; other site 1001583002295 conserved gate region; other site 1001583002296 putative PBP binding loops; other site 1001583002297 ABC-ATPase subunit interface; other site 1001583002298 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1001583002299 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001583002300 Walker A/P-loop; other site 1001583002301 ATP binding site [chemical binding]; other site 1001583002302 Q-loop/lid; other site 1001583002303 ABC transporter signature motif; other site 1001583002304 Walker B; other site 1001583002305 D-loop; other site 1001583002306 H-loop/switch region; other site 1001583002307 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1001583002308 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1001583002309 substrate binding pocket [chemical binding]; other site 1001583002310 membrane-bound complex binding site; other site 1001583002311 hinge residues; other site 1001583002312 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1001583002313 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1001583002314 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1001583002315 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1001583002316 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1001583002317 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1001583002318 Helix-turn-helix domain; Region: HTH_25; pfam13413 1001583002319 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1001583002320 competence damage-inducible protein A; Provisional; Region: PRK00549 1001583002321 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1001583002322 putative MPT binding site; other site 1001583002323 Competence-damaged protein; Region: CinA; pfam02464 1001583002324 recombinase A; Provisional; Region: recA; PRK09354 1001583002325 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1001583002326 hexamer interface [polypeptide binding]; other site 1001583002327 Walker A motif; other site 1001583002328 ATP binding site [chemical binding]; other site 1001583002329 Walker B motif; other site 1001583002330 phosphodiesterase; Provisional; Region: PRK12704 1001583002331 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1001583002332 Zn2+ binding site [ion binding]; other site 1001583002333 Mg2+ binding site [ion binding]; other site 1001583002334 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1001583002335 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1001583002336 putative active site [active] 1001583002337 metal binding site [ion binding]; metal-binding site 1001583002338 homodimer binding site [polypeptide binding]; other site 1001583002339 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1001583002340 MutS domain I; Region: MutS_I; pfam01624 1001583002341 MutS domain II; Region: MutS_II; pfam05188 1001583002342 MutS domain III; Region: MutS_III; pfam05192 1001583002343 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1001583002344 Walker A/P-loop; other site 1001583002345 ATP binding site [chemical binding]; other site 1001583002346 Q-loop/lid; other site 1001583002347 ABC transporter signature motif; other site 1001583002348 Walker B; other site 1001583002349 D-loop; other site 1001583002350 H-loop/switch region; other site 1001583002351 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1001583002352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001583002353 ATP binding site [chemical binding]; other site 1001583002354 Mg2+ binding site [ion binding]; other site 1001583002355 G-X-G motif; other site 1001583002356 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1001583002357 ATP binding site [chemical binding]; other site 1001583002358 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1001583002359 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1001583002360 RuvA N terminal domain; Region: RuvA_N; pfam01330 1001583002361 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1001583002362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001583002363 Walker A motif; other site 1001583002364 ATP binding site [chemical binding]; other site 1001583002365 Walker B motif; other site 1001583002366 arginine finger; other site 1001583002367 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1001583002368 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1001583002369 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1001583002370 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1001583002371 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1001583002372 Preprotein translocase subunit; Region: YajC; pfam02699 1001583002373 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1001583002374 active site 1001583002375 DNA polymerase IV; Validated; Region: PRK02406 1001583002376 DNA binding site [nucleotide binding] 1001583002377 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1001583002378 DHH family; Region: DHH; pfam01368 1001583002379 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1001583002380 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1001583002381 ATP binding site [chemical binding]; other site 1001583002382 Mg++ binding site [ion binding]; other site 1001583002383 motif III; other site 1001583002384 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001583002385 nucleotide binding region [chemical binding]; other site 1001583002386 ATP-binding site [chemical binding]; other site 1001583002387 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1001583002388 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1001583002389 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1001583002390 motif 1; other site 1001583002391 active site 1001583002392 motif 2; other site 1001583002393 motif 3; other site 1001583002394 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1001583002395 DHHA1 domain; Region: DHHA1; pfam02272 1001583002396 hypothetical protein; Provisional; Region: PRK05473 1001583002397 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1001583002398 hypothetical protein; Provisional; Region: PRK13678 1001583002399 Cell division protein ZapA; Region: ZapA; pfam05164 1001583002400 Colicin V production protein; Region: Colicin_V; pfam02674 1001583002401 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1001583002402 MutS domain III; Region: MutS_III; pfam05192 1001583002403 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001583002404 Walker A/P-loop; other site 1001583002405 ATP binding site [chemical binding]; other site 1001583002406 Q-loop/lid; other site 1001583002407 ABC transporter signature motif; other site 1001583002408 Walker B; other site 1001583002409 D-loop; other site 1001583002410 H-loop/switch region; other site 1001583002411 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1001583002412 Smr domain; Region: Smr; pfam01713 1001583002413 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1001583002414 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1001583002415 catalytic residues [active] 1001583002416 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1001583002417 glutamate racemase; Provisional; Region: PRK00865 1001583002418 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1001583002419 active site 1001583002420 dimerization interface [polypeptide binding]; other site 1001583002421 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1001583002422 active site 1001583002423 metal binding site [ion binding]; metal-binding site 1001583002424 homotetramer interface [polypeptide binding]; other site 1001583002425 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1001583002426 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001583002427 dimerization interface [polypeptide binding]; other site 1001583002428 putative DNA binding site [nucleotide binding]; other site 1001583002429 putative Zn2+ binding site [ion binding]; other site 1001583002430 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001583002431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583002432 putative substrate translocation pore; other site 1001583002433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583002434 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1001583002435 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1001583002436 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 1001583002437 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1001583002438 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1001583002439 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1001583002440 active site 1001583002441 catabolite control protein A; Region: ccpA; TIGR01481 1001583002442 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1001583002443 DNA binding site [nucleotide binding] 1001583002444 domain linker motif; other site 1001583002445 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1001583002446 dimerization interface [polypeptide binding]; other site 1001583002447 effector binding site; other site 1001583002448 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1001583002449 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1001583002450 Walker A/P-loop; other site 1001583002451 ATP binding site [chemical binding]; other site 1001583002452 Q-loop/lid; other site 1001583002453 ABC transporter signature motif; other site 1001583002454 Walker B; other site 1001583002455 D-loop; other site 1001583002456 H-loop/switch region; other site 1001583002457 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1001583002458 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1001583002459 substrate binding pocket [chemical binding]; other site 1001583002460 membrane-bound complex binding site; other site 1001583002461 hinge residues; other site 1001583002462 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1001583002463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001583002464 dimer interface [polypeptide binding]; other site 1001583002465 conserved gate region; other site 1001583002466 putative PBP binding loops; other site 1001583002467 ABC-ATPase subunit interface; other site 1001583002468 hypothetical protein; Validated; Region: PRK00110 1001583002469 Type II/IV secretion system protein; Region: T2SE; pfam00437 1001583002470 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1001583002471 Walker A motif; other site 1001583002472 ATP binding site [chemical binding]; other site 1001583002473 Walker B motif; other site 1001583002474 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1001583002475 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1001583002476 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1001583002477 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1001583002478 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001583002479 S-adenosylmethionine binding site [chemical binding]; other site 1001583002480 propionate/acetate kinase; Provisional; Region: PRK12379 1001583002481 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1001583002482 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1001583002483 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1001583002484 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1001583002485 active site 1001583002486 catalytic tetrad [active] 1001583002487 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 1001583002488 putative active site [active] 1001583002489 putative metal binding site [ion binding]; other site 1001583002490 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1001583002491 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1001583002492 active site 1001583002493 metal binding site [ion binding]; metal-binding site 1001583002494 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1001583002495 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1001583002496 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1001583002497 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001583002498 active site 1001583002499 motif I; other site 1001583002500 motif II; other site 1001583002501 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001583002502 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 1001583002503 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1001583002504 legume lectins; Region: lectin_L-type; cl14058 1001583002505 homotetramer interaction site [polypeptide binding]; other site 1001583002506 carbohydrate binding site [chemical binding]; other site 1001583002507 metal binding site [ion binding]; metal-binding site 1001583002508 Collagen binding domain; Region: Collagen_bind; pfam05737 1001583002509 Cna protein B-type domain; Region: Cna_B; pfam05738 1001583002510 amino acid transporter; Region: 2A0306; TIGR00909 1001583002511 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1001583002512 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1001583002513 classical (c) SDRs; Region: SDR_c; cd05233 1001583002514 NAD(P) binding site [chemical binding]; other site 1001583002515 active site 1001583002516 Aldo/keto reductases, related to diketogulonate reductase [General function prediction only]; Region: ARA1; COG0656 1001583002517 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1001583002518 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1001583002519 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1001583002520 tetramer interfaces [polypeptide binding]; other site 1001583002521 binuclear metal-binding site [ion binding]; other site 1001583002522 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1001583002523 active site 1001583002524 general stress protein 13; Validated; Region: PRK08059 1001583002525 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1001583002526 RNA binding site [nucleotide binding]; other site 1001583002527 AAA ATPase domain; Region: AAA_16; pfam13191 1001583002528 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1001583002529 Uncharacterized conserved protein [Function unknown]; Region: COG3410 1001583002530 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1001583002531 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1001583002532 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1001583002533 ArsC family; Region: ArsC; pfam03960 1001583002534 putative catalytic residues [active] 1001583002535 thiol/disulfide switch; other site 1001583002536 adaptor protein; Provisional; Region: PRK02315 1001583002537 EAL domain; Region: EAL; pfam00563 1001583002538 N-glycosyltransferase; Provisional; Region: PRK11204 1001583002539 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1001583002540 DXD motif; other site 1001583002541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1001583002542 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 1001583002543 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1001583002544 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1001583002545 active site 1001583002546 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1001583002547 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1001583002548 HIGH motif; other site 1001583002549 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1001583002550 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1001583002551 active site 1001583002552 KMSKS motif; other site 1001583002553 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1001583002554 tRNA binding surface [nucleotide binding]; other site 1001583002555 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1001583002556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1001583002557 Walker A/P-loop; other site 1001583002558 ATP binding site [chemical binding]; other site 1001583002559 Q-loop/lid; other site 1001583002560 ABC transporter signature motif; other site 1001583002561 Walker B; other site 1001583002562 D-loop; other site 1001583002563 H-loop/switch region; other site 1001583002564 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1001583002565 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1001583002566 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1001583002567 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1001583002568 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1001583002569 RNA binding surface [nucleotide binding]; other site 1001583002570 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1001583002571 putative substrate binding site [chemical binding]; other site 1001583002572 putative ATP binding site [chemical binding]; other site 1001583002573 dipeptidase PepV; Reviewed; Region: PRK07318 1001583002574 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1001583002575 active site 1001583002576 metal binding site [ion binding]; metal-binding site 1001583002577 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1001583002578 Ligand Binding Site [chemical binding]; other site 1001583002579 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1001583002580 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1001583002581 hexamer interface [polypeptide binding]; other site 1001583002582 ligand binding site [chemical binding]; other site 1001583002583 putative active site [active] 1001583002584 NAD(P) binding site [chemical binding]; other site 1001583002585 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1001583002586 Predicted small secreted protein [Function unknown]; Region: COG5584 1001583002587 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1001583002588 catalytic residues [active] 1001583002589 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1001583002590 putative tRNA-binding site [nucleotide binding]; other site 1001583002591 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1001583002592 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1001583002593 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1001583002594 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1001583002595 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1001583002596 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1001583002597 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1001583002598 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1001583002599 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1001583002600 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1001583002601 xanthine permease; Region: pbuX; TIGR03173 1001583002602 guanine deaminase; Region: guan_deamin; TIGR02967 1001583002603 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1001583002604 active site 1001583002605 DNA polymerase I; Provisional; Region: PRK05755 1001583002606 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1001583002607 active site 1001583002608 metal binding site 1 [ion binding]; metal-binding site 1001583002609 putative 5' ssDNA interaction site; other site 1001583002610 metal binding site 3; metal-binding site 1001583002611 metal binding site 2 [ion binding]; metal-binding site 1001583002612 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1001583002613 putative DNA binding site [nucleotide binding]; other site 1001583002614 putative metal binding site [ion binding]; other site 1001583002615 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1001583002616 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1001583002617 active site 1001583002618 DNA binding site [nucleotide binding] 1001583002619 catalytic site [active] 1001583002620 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1001583002621 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1001583002622 DNA binding site [nucleotide binding] 1001583002623 catalytic residue [active] 1001583002624 H2TH interface [polypeptide binding]; other site 1001583002625 putative catalytic residues [active] 1001583002626 turnover-facilitating residue; other site 1001583002627 intercalation triad [nucleotide binding]; other site 1001583002628 8OG recognition residue [nucleotide binding]; other site 1001583002629 putative reading head residues; other site 1001583002630 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1001583002631 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1001583002632 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1001583002633 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1001583002634 CoA-binding site [chemical binding]; other site 1001583002635 ATP-binding [chemical binding]; other site 1001583002636 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1001583002637 ATP cone domain; Region: ATP-cone; pfam03477 1001583002638 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1001583002639 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1001583002640 primosomal protein DnaI; Reviewed; Region: PRK08939 1001583002641 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1001583002642 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001583002643 Walker A motif; other site 1001583002644 ATP binding site [chemical binding]; other site 1001583002645 Walker B motif; other site 1001583002646 arginine finger; other site 1001583002647 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1001583002648 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1001583002649 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1001583002650 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1001583002651 active site 1001583002652 dimer interface [polypeptide binding]; other site 1001583002653 motif 1; other site 1001583002654 motif 2; other site 1001583002655 motif 3; other site 1001583002656 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1001583002657 anticodon binding site; other site 1001583002658 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1001583002659 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1001583002660 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1001583002661 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1001583002662 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1001583002663 23S rRNA binding site [nucleotide binding]; other site 1001583002664 L21 binding site [polypeptide binding]; other site 1001583002665 L13 binding site [polypeptide binding]; other site 1001583002666 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1001583002667 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001583002668 active site 1001583002669 motif I; other site 1001583002670 motif II; other site 1001583002671 GTPase YqeH; Provisional; Region: PRK13796 1001583002672 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1001583002673 GTP/Mg2+ binding site [chemical binding]; other site 1001583002674 G4 box; other site 1001583002675 G5 box; other site 1001583002676 G1 box; other site 1001583002677 Switch I region; other site 1001583002678 G2 box; other site 1001583002679 G3 box; other site 1001583002680 Switch II region; other site 1001583002681 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 1001583002682 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1001583002683 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1001583002684 active site 1001583002685 (T/H)XGH motif; other site 1001583002686 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1001583002687 Zn2+ binding site [ion binding]; other site 1001583002688 Mg2+ binding site [ion binding]; other site 1001583002689 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1001583002690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001583002691 S-adenosylmethionine binding site [chemical binding]; other site 1001583002692 hypothetical protein; Provisional; Region: PRK13670 1001583002693 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1001583002694 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1001583002695 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1001583002696 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001583002697 active site 1001583002698 motif I; other site 1001583002699 motif II; other site 1001583002700 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1001583002701 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001583002702 dimerization interface [polypeptide binding]; other site 1001583002703 putative DNA binding site [nucleotide binding]; other site 1001583002704 putative Zn2+ binding site [ion binding]; other site 1001583002705 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 1001583002706 active site 1001583002707 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1001583002708 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1001583002709 NAD binding site [chemical binding]; other site 1001583002710 substrate binding site [chemical binding]; other site 1001583002711 catalytic Zn binding site [ion binding]; other site 1001583002712 tetramer interface [polypeptide binding]; other site 1001583002713 structural Zn binding site [ion binding]; other site 1001583002714 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1001583002715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001583002716 active site 1001583002717 phosphorylation site [posttranslational modification] 1001583002718 intermolecular recognition site; other site 1001583002719 dimerization interface [polypeptide binding]; other site 1001583002720 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1001583002721 DNA binding site [nucleotide binding] 1001583002722 sensory histidine kinase CreC; Provisional; Region: PRK11100 1001583002723 HAMP domain; Region: HAMP; pfam00672 1001583002724 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1001583002725 dimer interface [polypeptide binding]; other site 1001583002726 phosphorylation site [posttranslational modification] 1001583002727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001583002728 ATP binding site [chemical binding]; other site 1001583002729 Mg2+ binding site [ion binding]; other site 1001583002730 G-X-G motif; other site 1001583002731 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1001583002732 OxaA-like protein precursor; Provisional; Region: PRK02463 1001583002733 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1001583002734 Acylphosphatase; Region: Acylphosphatase; pfam00708 1001583002735 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1001583002736 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1001583002737 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1001583002738 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1001583002739 Zn2+ binding site [ion binding]; other site 1001583002740 Mg2+ binding site [ion binding]; other site 1001583002741 Predicted transcriptional regulators [Transcription]; Region: COG1733 1001583002742 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1001583002743 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1001583002744 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1001583002745 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1001583002746 dimer interface [polypeptide binding]; other site 1001583002747 motif 1; other site 1001583002748 active site 1001583002749 motif 2; other site 1001583002750 motif 3; other site 1001583002751 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1001583002752 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1001583002753 putative tRNA-binding site [nucleotide binding]; other site 1001583002754 B3/4 domain; Region: B3_4; pfam03483 1001583002755 tRNA synthetase B5 domain; Region: B5; smart00874 1001583002756 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1001583002757 dimer interface [polypeptide binding]; other site 1001583002758 motif 1; other site 1001583002759 motif 3; other site 1001583002760 motif 2; other site 1001583002761 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1001583002762 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1001583002763 YceG-like family; Region: YceG; pfam02618 1001583002764 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1001583002765 dimerization interface [polypeptide binding]; other site 1001583002766 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1001583002767 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1001583002768 Sugar specificity; other site 1001583002769 Pyrimidine base specificity; other site 1001583002770 ATP-binding site [chemical binding]; other site 1001583002771 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1001583002772 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1001583002773 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1001583002774 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1001583002775 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1001583002776 Domain of unknown function (DUF378); Region: DUF378; pfam04070 1001583002777 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1001583002778 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1001583002779 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1001583002780 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1001583002781 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1001583002782 Rhomboid family; Region: Rhomboid; pfam01694 1001583002783 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1001583002784 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1001583002785 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1001583002786 nucleotide binding site [chemical binding]; other site 1001583002787 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1001583002788 active site residue [active] 1001583002789 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 1001583002790 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1001583002791 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1001583002792 active site 1001583002793 catalytic site [active] 1001583002794 metal binding site [ion binding]; metal-binding site 1001583002795 dimer interface [polypeptide binding]; other site 1001583002796 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1001583002797 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1001583002798 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1001583002799 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1001583002800 DNA binding residues [nucleotide binding] 1001583002801 putative dimer interface [polypeptide binding]; other site 1001583002802 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1001583002803 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1001583002804 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1001583002805 dUTPase; Region: dUTPase_2; pfam08761 1001583002806 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1001583002807 active site 1001583002808 homodimer interface [polypeptide binding]; other site 1001583002809 metal binding site [ion binding]; metal-binding site 1001583002810 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001583002811 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1001583002812 Protein of unknown function (DUF464); Region: DUF464; pfam04327 1001583002813 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1001583002814 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1001583002815 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1001583002816 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1001583002817 active site 1001583002818 elongation factor P; Validated; Region: PRK00529 1001583002819 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1001583002820 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1001583002821 RNA binding site [nucleotide binding]; other site 1001583002822 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1001583002823 RNA binding site [nucleotide binding]; other site 1001583002824 Asp23 family; Region: Asp23; pfam03780 1001583002825 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1001583002826 putative RNA binding site [nucleotide binding]; other site 1001583002827 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1001583002828 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1001583002829 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1001583002830 homodimer interface [polypeptide binding]; other site 1001583002831 NADP binding site [chemical binding]; other site 1001583002832 substrate binding site [chemical binding]; other site 1001583002833 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1001583002834 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1001583002835 generic binding surface II; other site 1001583002836 generic binding surface I; other site 1001583002837 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1001583002838 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1001583002839 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1001583002840 substrate binding pocket [chemical binding]; other site 1001583002841 chain length determination region; other site 1001583002842 substrate-Mg2+ binding site; other site 1001583002843 catalytic residues [active] 1001583002844 aspartate-rich region 1; other site 1001583002845 active site lid residues [active] 1001583002846 aspartate-rich region 2; other site 1001583002847 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1001583002848 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1001583002849 arginine repressor; Provisional; Region: PRK04280 1001583002850 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1001583002851 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1001583002852 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1001583002853 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1001583002854 Walker A/P-loop; other site 1001583002855 ATP binding site [chemical binding]; other site 1001583002856 Q-loop/lid; other site 1001583002857 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1001583002858 ABC transporter signature motif; other site 1001583002859 Walker B; other site 1001583002860 D-loop; other site 1001583002861 H-loop/switch region; other site 1001583002862 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1001583002863 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1001583002864 catalytic site [active] 1001583002865 G-X2-G-X-G-K; other site 1001583002866 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1001583002867 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1001583002868 Flavoprotein; Region: Flavoprotein; pfam02441 1001583002869 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1001583002870 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1001583002871 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1001583002872 ATP binding site [chemical binding]; other site 1001583002873 putative Mg++ binding site [ion binding]; other site 1001583002874 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001583002875 nucleotide binding region [chemical binding]; other site 1001583002876 ATP-binding site [chemical binding]; other site 1001583002877 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1001583002878 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1001583002879 putative active site [active] 1001583002880 substrate binding site [chemical binding]; other site 1001583002881 putative cosubstrate binding site; other site 1001583002882 catalytic site [active] 1001583002883 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1001583002884 substrate binding site [chemical binding]; other site 1001583002885 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1001583002886 NusB family; Region: NusB; pfam01029 1001583002887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001583002888 S-adenosylmethionine binding site [chemical binding]; other site 1001583002889 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1001583002890 active site 1001583002891 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1001583002892 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1001583002893 active site 1001583002894 ATP binding site [chemical binding]; other site 1001583002895 substrate binding site [chemical binding]; other site 1001583002896 activation loop (A-loop); other site 1001583002897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1001583002898 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1001583002899 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1001583002900 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1001583002901 GTPase RsgA; Reviewed; Region: PRK00098 1001583002902 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1001583002903 RNA binding site [nucleotide binding]; other site 1001583002904 homodimer interface [polypeptide binding]; other site 1001583002905 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1001583002906 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1001583002907 GTP/Mg2+ binding site [chemical binding]; other site 1001583002908 G4 box; other site 1001583002909 G5 box; other site 1001583002910 G1 box; other site 1001583002911 Switch I region; other site 1001583002912 G2 box; other site 1001583002913 G3 box; other site 1001583002914 Switch II region; other site 1001583002915 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1001583002916 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1001583002917 substrate binding site [chemical binding]; other site 1001583002918 hexamer interface [polypeptide binding]; other site 1001583002919 metal binding site [ion binding]; metal-binding site 1001583002920 Thiamine pyrophosphokinase; Region: TPK; cd07995 1001583002921 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1001583002922 active site 1001583002923 dimerization interface [polypeptide binding]; other site 1001583002924 thiamine binding site [chemical binding]; other site 1001583002925 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1001583002926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1001583002927 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1001583002928 DAK2 domain; Region: Dak2; pfam02734 1001583002929 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1001583002930 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1001583002931 generic binding surface II; other site 1001583002932 ssDNA binding site; other site 1001583002933 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1001583002934 ATP binding site [chemical binding]; other site 1001583002935 putative Mg++ binding site [ion binding]; other site 1001583002936 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001583002937 nucleotide binding region [chemical binding]; other site 1001583002938 ATP-binding site [chemical binding]; other site 1001583002939 putative phosphate acyltransferase; Provisional; Region: PRK05331 1001583002940 acyl carrier protein; Provisional; Region: acpP; PRK00982 1001583002941 ribonuclease III; Reviewed; Region: rnc; PRK00102 1001583002942 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1001583002943 dimerization interface [polypeptide binding]; other site 1001583002944 active site 1001583002945 metal binding site [ion binding]; metal-binding site 1001583002946 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1001583002947 dsRNA binding site [nucleotide binding]; other site 1001583002948 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1001583002949 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1001583002950 Walker A/P-loop; other site 1001583002951 ATP binding site [chemical binding]; other site 1001583002952 Q-loop/lid; other site 1001583002953 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1001583002954 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1001583002955 ABC transporter signature motif; other site 1001583002956 Walker B; other site 1001583002957 D-loop; other site 1001583002958 H-loop/switch region; other site 1001583002959 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1001583002960 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1001583002961 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1001583002962 P loop; other site 1001583002963 GTP binding site [chemical binding]; other site 1001583002964 putative DNA-binding protein; Validated; Region: PRK00118 1001583002965 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1001583002966 signal recognition particle protein; Provisional; Region: PRK10867 1001583002967 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1001583002968 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1001583002969 P loop; other site 1001583002970 GTP binding site [chemical binding]; other site 1001583002971 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1001583002972 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1001583002973 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1001583002974 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1001583002975 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1001583002976 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001583002977 motif II; other site 1001583002978 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1001583002979 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1001583002980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1001583002981 Walker A motif; other site 1001583002982 ATP binding site [chemical binding]; other site 1001583002983 Walker B motif; other site 1001583002984 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 1001583002985 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1001583002986 metal ion-dependent adhesion site (MIDAS); other site 1001583002987 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1001583002988 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1001583002989 KH domain; Region: KH_4; pfam13083 1001583002990 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1001583002991 RimM N-terminal domain; Region: RimM; pfam01782 1001583002992 PRC-barrel domain; Region: PRC; pfam05239 1001583002993 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1001583002994 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1001583002995 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1001583002996 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001583002997 MarR family; Region: MarR_2; pfam12802 1001583002998 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1001583002999 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1001583003000 dimer interface [polypeptide binding]; other site 1001583003001 active site 1001583003002 CoA binding pocket [chemical binding]; other site 1001583003003 acyl carrier protein; Provisional; Region: acpP; PRK00982 1001583003004 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1001583003005 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1001583003006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001583003007 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1001583003008 NAD(P) binding site [chemical binding]; other site 1001583003009 active site 1001583003010 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1001583003011 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1001583003012 dimer interface [polypeptide binding]; other site 1001583003013 active site 1001583003014 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1001583003015 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1001583003016 carboxyltransferase (CT) interaction site; other site 1001583003017 biotinylation site [posttranslational modification]; other site 1001583003018 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1001583003019 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1001583003020 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1001583003021 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1001583003022 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1001583003023 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1001583003024 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1001583003025 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1001583003026 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 1001583003027 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1001583003028 NAD binding site [chemical binding]; other site 1001583003029 homotetramer interface [polypeptide binding]; other site 1001583003030 homodimer interface [polypeptide binding]; other site 1001583003031 substrate binding site [chemical binding]; other site 1001583003032 active site 1001583003033 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1001583003034 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1001583003035 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1001583003036 BioY family; Region: BioY; pfam02632 1001583003037 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 1001583003038 metal binding site [ion binding]; metal-binding site 1001583003039 Isochorismatase family; Region: Isochorismatase; pfam00857 1001583003040 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1001583003041 catalytic triad [active] 1001583003042 conserved cis-peptide bond; other site 1001583003043 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1001583003044 LytTr DNA-binding domain; Region: LytTR; smart00850 1001583003045 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1001583003046 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1001583003047 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1001583003048 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1001583003049 conserved cys residue [active] 1001583003050 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1001583003051 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 1001583003052 catalytic Zn binding site [ion binding]; other site 1001583003053 NAD binding site [chemical binding]; other site 1001583003054 structural Zn binding site [ion binding]; other site 1001583003055 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1001583003056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001583003057 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1001583003058 dimerization interface [polypeptide binding]; other site 1001583003059 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1001583003060 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1001583003061 DNA binding residues [nucleotide binding] 1001583003062 putative dimer interface [polypeptide binding]; other site 1001583003063 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1001583003064 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1001583003065 active site 1001583003066 catalytic tetrad [active] 1001583003067 GTPase RsgA; Reviewed; Region: PRK01889 1001583003068 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1001583003069 RNA binding site [nucleotide binding]; other site 1001583003070 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1001583003071 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1001583003072 GTP/Mg2+ binding site [chemical binding]; other site 1001583003073 G4 box; other site 1001583003074 G5 box; other site 1001583003075 G1 box; other site 1001583003076 Switch I region; other site 1001583003077 G2 box; other site 1001583003078 G3 box; other site 1001583003079 Switch II region; other site 1001583003080 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1001583003081 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1001583003082 tetramer interface [polypeptide binding]; other site 1001583003083 heme binding pocket [chemical binding]; other site 1001583003084 NADPH binding site [chemical binding]; other site 1001583003085 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1001583003086 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1001583003087 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1001583003088 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1001583003089 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1001583003090 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001583003091 non-specific DNA binding site [nucleotide binding]; other site 1001583003092 salt bridge; other site 1001583003093 sequence-specific DNA binding site [nucleotide binding]; other site 1001583003094 inner membrane transporter YjeM; Provisional; Region: PRK15238 1001583003095 Peptidase family C69; Region: Peptidase_C69; pfam03577 1001583003096 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1001583003097 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1001583003098 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1001583003099 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1001583003100 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 1001583003101 active site 1 [active] 1001583003102 dimer interface [polypeptide binding]; other site 1001583003103 hexamer interface [polypeptide binding]; other site 1001583003104 active site 2 [active] 1001583003105 glycerol kinase; Provisional; Region: glpK; PRK00047 1001583003106 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1001583003107 N- and C-terminal domain interface [polypeptide binding]; other site 1001583003108 active site 1001583003109 MgATP binding site [chemical binding]; other site 1001583003110 catalytic site [active] 1001583003111 metal binding site [ion binding]; metal-binding site 1001583003112 glycerol binding site [chemical binding]; other site 1001583003113 homotetramer interface [polypeptide binding]; other site 1001583003114 homodimer interface [polypeptide binding]; other site 1001583003115 FBP binding site [chemical binding]; other site 1001583003116 protein IIAGlc interface [polypeptide binding]; other site 1001583003117 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001583003118 sequence-specific DNA binding site [nucleotide binding]; other site 1001583003119 salt bridge; other site 1001583003120 Firmicu-CTERM domain; Region: Firmicu_CTERM; TIGR04145 1001583003121 exosortase family protein XrtG; Region: exosort_Gpos; TIGR03110 1001583003122 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1001583003123 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1001583003124 DXD motif; other site 1001583003125 conserved hypothetical integral membrane protein; Region: TIGR03766 1001583003126 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1001583003127 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1001583003128 Walker A/P-loop; other site 1001583003129 ATP binding site [chemical binding]; other site 1001583003130 Q-loop/lid; other site 1001583003131 ABC transporter signature motif; other site 1001583003132 Walker B; other site 1001583003133 D-loop; other site 1001583003134 H-loop/switch region; other site 1001583003135 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1001583003136 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1001583003137 FtsX-like permease family; Region: FtsX; pfam02687 1001583003138 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001583003139 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001583003140 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1001583003141 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1001583003142 active site 1001583003143 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1001583003144 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1001583003145 active site 1001583003146 metal binding site [ion binding]; metal-binding site 1001583003147 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1001583003148 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1001583003149 Walker A/P-loop; other site 1001583003150 ATP binding site [chemical binding]; other site 1001583003151 Q-loop/lid; other site 1001583003152 ABC transporter signature motif; other site 1001583003153 Walker B; other site 1001583003154 D-loop; other site 1001583003155 H-loop/switch region; other site 1001583003156 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1001583003157 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1001583003158 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001583003159 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001583003160 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1001583003161 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1001583003162 phosphate binding site [ion binding]; other site 1001583003163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1001583003164 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1001583003165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1001583003166 K+ potassium transporter; Region: K_trans; pfam02705 1001583003167 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1001583003168 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 1001583003169 putative NAD(P) binding site [chemical binding]; other site 1001583003170 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001583003171 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001583003172 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1001583003173 NAD(P) binding site [chemical binding]; other site 1001583003174 active site 1001583003175 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1001583003176 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1001583003177 DNA binding residues [nucleotide binding] 1001583003178 putative dimer interface [polypeptide binding]; other site 1001583003179 MarR family; Region: MarR_2; pfam12802 1001583003180 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078 1001583003181 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1001583003182 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1001583003183 catalytic Zn binding site [ion binding]; other site 1001583003184 NAD(P) binding site [chemical binding]; other site 1001583003185 structural Zn binding site [ion binding]; other site 1001583003186 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1001583003187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001583003188 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1001583003189 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1001583003190 active site 1001583003191 catalytic tetrad [active] 1001583003192 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1001583003193 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1001583003194 active site 1001583003195 catalytic tetrad [active] 1001583003196 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1001583003197 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1001583003198 metal binding site [ion binding]; metal-binding site 1001583003199 dimer interface [polypeptide binding]; other site 1001583003200 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001583003201 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1001583003202 active site 1001583003203 motif I; other site 1001583003204 motif II; other site 1001583003205 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1001583003206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001583003207 S-adenosylmethionine binding site [chemical binding]; other site 1001583003208 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1001583003209 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1001583003210 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1001583003211 homotetramer interface [polypeptide binding]; other site 1001583003212 FMN binding site [chemical binding]; other site 1001583003213 homodimer contacts [polypeptide binding]; other site 1001583003214 putative active site [active] 1001583003215 putative substrate binding site [chemical binding]; other site 1001583003216 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1001583003217 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1001583003218 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 1001583003219 diphosphomevalonate decarboxylase; Region: PLN02407 1001583003220 mevalonate kinase; Region: mevalon_kin; TIGR00549 1001583003221 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1001583003222 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1001583003223 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1001583003224 active site 1001583003225 catalytic site [active] 1001583003226 substrate binding site [chemical binding]; other site 1001583003227 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1001583003228 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1001583003229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1001583003230 aspartate aminotransferase; Provisional; Region: PRK05764 1001583003231 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1001583003232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001583003233 homodimer interface [polypeptide binding]; other site 1001583003234 catalytic residue [active] 1001583003235 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1001583003236 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1001583003237 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001583003238 MarR family; Region: MarR_2; cl17246 1001583003239 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1001583003240 active site residue [active] 1001583003241 Transglycosylase; Region: Transgly; pfam00912 1001583003242 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1001583003243 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1001583003244 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1001583003245 hypothetical protein; Provisional; Region: PRK13660 1001583003246 cell division protein GpsB; Provisional; Region: PRK14127 1001583003247 DivIVA domain; Region: DivI1A_domain; TIGR03544 1001583003248 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1001583003249 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1001583003250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1001583003251 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1001583003252 nucleotide binding site/active site [active] 1001583003253 HIT family signature motif; other site 1001583003254 catalytic residue [active] 1001583003255 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1001583003256 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1001583003257 nudix motif; other site 1001583003258 CAAX protease self-immunity; Region: Abi; pfam02517 1001583003259 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001583003260 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001583003261 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1001583003262 dimer interface [polypeptide binding]; other site 1001583003263 FMN binding site [chemical binding]; other site 1001583003264 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1001583003265 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1001583003266 RNA/DNA hybrid binding site [nucleotide binding]; other site 1001583003267 active site 1001583003268 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1001583003269 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1001583003270 Potassium binding sites [ion binding]; other site 1001583003271 Cesium cation binding sites [ion binding]; other site 1001583003272 lipoprotein signal peptidase; Provisional; Region: PRK14797 1001583003273 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1001583003274 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1001583003275 RNA binding surface [nucleotide binding]; other site 1001583003276 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1001583003277 active site 1001583003278 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1001583003279 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001583003280 active site 1001583003281 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1001583003282 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1001583003283 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1001583003284 catalytic site [active] 1001583003285 subunit interface [polypeptide binding]; other site 1001583003286 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1001583003287 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 1001583003288 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1001583003289 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1001583003290 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 1001583003291 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1001583003292 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1001583003293 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1001583003294 MarR family; Region: MarR_2; pfam12802 1001583003295 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1001583003296 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1001583003297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583003298 putative substrate translocation pore; other site 1001583003299 EDD domain protein, DegV family; Region: DegV; TIGR00762 1001583003300 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1001583003301 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1001583003302 Predicted membrane protein [Function unknown]; Region: COG2246 1001583003303 GtrA-like protein; Region: GtrA; pfam04138 1001583003304 VanZ like family; Region: VanZ; cl01971 1001583003305 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1001583003306 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1001583003307 minor groove reading motif; other site 1001583003308 helix-hairpin-helix signature motif; other site 1001583003309 substrate binding pocket [chemical binding]; other site 1001583003310 active site 1001583003311 Helix-Turn-Helix DNA binding domain of BmrR-like transcription regulators; Region: HTH_BmrR-like; cd04768 1001583003312 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1001583003313 DNA binding residues [nucleotide binding] 1001583003314 drug binding residues [chemical binding]; other site 1001583003315 dimer interface [polypeptide binding]; other site 1001583003316 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1001583003317 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 1001583003318 putative NAD(P) binding site [chemical binding]; other site 1001583003319 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1001583003320 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1001583003321 active site 1001583003322 metal binding site [ion binding]; metal-binding site 1001583003323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001583003324 S-adenosylmethionine binding site [chemical binding]; other site 1001583003325 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 1001583003326 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1001583003327 active site 1001583003328 DNA binding site [nucleotide binding] 1001583003329 Int/Topo IB signature motif; other site 1001583003330 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1001583003331 nudix motif; other site 1001583003332 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1001583003333 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1001583003334 SelR domain; Region: SelR; pfam01641 1001583003335 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1001583003336 DHH family; Region: DHH; pfam01368 1001583003337 DHHA2 domain; Region: DHHA2; pfam02833 1001583003338 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1001583003339 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001583003340 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1001583003341 dimerization interface [polypeptide binding]; other site 1001583003342 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1001583003343 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1001583003344 CAP-like domain; other site 1001583003345 active site 1001583003346 primary dimer interface [polypeptide binding]; other site 1001583003347 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1001583003348 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1001583003349 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1001583003350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001583003351 ATP binding site [chemical binding]; other site 1001583003352 Mg2+ binding site [ion binding]; other site 1001583003353 G-X-G motif; other site 1001583003354 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1001583003355 anchoring element; other site 1001583003356 dimer interface [polypeptide binding]; other site 1001583003357 ATP binding site [chemical binding]; other site 1001583003358 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1001583003359 active site 1001583003360 putative metal-binding site [ion binding]; other site 1001583003361 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1001583003362 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1001583003363 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1001583003364 active site 1001583003365 catalytic residues [active] 1001583003366 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1001583003367 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001583003368 Walker A motif; other site 1001583003369 ATP binding site [chemical binding]; other site 1001583003370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001583003371 Walker B motif; other site 1001583003372 arginine finger; other site 1001583003373 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1001583003374 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1001583003375 active site 1001583003376 HslU subunit interaction site [polypeptide binding]; other site 1001583003377 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1001583003378 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1001583003379 active site 1001583003380 DNA binding site [nucleotide binding] 1001583003381 Int/Topo IB signature motif; other site 1001583003382 DNA topoisomerase I; Validated; Region: PRK05582 1001583003383 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1001583003384 active site 1001583003385 interdomain interaction site; other site 1001583003386 putative metal-binding site [ion binding]; other site 1001583003387 nucleotide binding site [chemical binding]; other site 1001583003388 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1001583003389 domain I; other site 1001583003390 DNA binding groove [nucleotide binding] 1001583003391 phosphate binding site [ion binding]; other site 1001583003392 domain II; other site 1001583003393 domain III; other site 1001583003394 nucleotide binding site [chemical binding]; other site 1001583003395 catalytic site [active] 1001583003396 domain IV; other site 1001583003397 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1001583003398 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1001583003399 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1001583003400 DNA protecting protein DprA; Region: dprA; TIGR00732 1001583003401 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1001583003402 RNA/DNA hybrid binding site [nucleotide binding]; other site 1001583003403 active site 1001583003404 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 1001583003405 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1001583003406 GTP/Mg2+ binding site [chemical binding]; other site 1001583003407 G4 box; other site 1001583003408 G5 box; other site 1001583003409 G1 box; other site 1001583003410 Switch I region; other site 1001583003411 G2 box; other site 1001583003412 G3 box; other site 1001583003413 Switch II region; other site 1001583003414 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1001583003415 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583003416 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583003417 Integrase core domain; Region: rve; pfam00665 1001583003418 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 1001583003419 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1001583003420 active site 1001583003421 catalytic triad [active] 1001583003422 oxyanion hole [active] 1001583003423 EDD domain protein, DegV family; Region: DegV; TIGR00762 1001583003424 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1001583003425 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1001583003426 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1001583003427 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1001583003428 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1001583003429 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583003430 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583003431 Integrase core domain; Region: rve; pfam00665 1001583003432 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1001583003433 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1001583003434 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1001583003435 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1001583003436 folate binding site [chemical binding]; other site 1001583003437 NADP+ binding site [chemical binding]; other site 1001583003438 thymidylate synthase; Region: thym_sym; TIGR03284 1001583003439 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1001583003440 dimerization interface [polypeptide binding]; other site 1001583003441 active site 1001583003442 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1001583003443 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001583003444 Walker A/P-loop; other site 1001583003445 ATP binding site [chemical binding]; other site 1001583003446 Q-loop/lid; other site 1001583003447 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1001583003448 ABC transporter signature motif; other site 1001583003449 Walker B; other site 1001583003450 D-loop; other site 1001583003451 ABC transporter; Region: ABC_tran_2; pfam12848 1001583003452 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1001583003453 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1001583003454 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1001583003455 active site 1001583003456 NTP binding site [chemical binding]; other site 1001583003457 metal binding triad [ion binding]; metal-binding site 1001583003458 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1001583003459 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1001583003460 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1001583003461 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1001583003462 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1001583003463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1001583003464 binding surface 1001583003465 TPR motif; other site 1001583003466 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1001583003467 binding surface 1001583003468 TPR motif; other site 1001583003469 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1001583003470 IHF dimer interface [polypeptide binding]; other site 1001583003471 IHF - DNA interface [nucleotide binding]; other site 1001583003472 GTP-binding protein Der; Reviewed; Region: PRK00093 1001583003473 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1001583003474 G1 box; other site 1001583003475 GTP/Mg2+ binding site [chemical binding]; other site 1001583003476 Switch I region; other site 1001583003477 G2 box; other site 1001583003478 Switch II region; other site 1001583003479 G3 box; other site 1001583003480 G4 box; other site 1001583003481 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1001583003482 G1 box; other site 1001583003483 GTP/Mg2+ binding site [chemical binding]; other site 1001583003484 Switch I region; other site 1001583003485 G2 box; other site 1001583003486 G3 box; other site 1001583003487 Switch II region; other site 1001583003488 G4 box; other site 1001583003489 G5 box; other site 1001583003490 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1001583003491 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1001583003492 RNA binding site [nucleotide binding]; other site 1001583003493 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1001583003494 RNA binding site [nucleotide binding]; other site 1001583003495 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1001583003496 RNA binding site [nucleotide binding]; other site 1001583003497 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1001583003498 RNA binding site [nucleotide binding]; other site 1001583003499 cytidylate kinase; Provisional; Region: cmk; PRK00023 1001583003500 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1001583003501 CMP-binding site; other site 1001583003502 The sites determining sugar specificity; other site 1001583003503 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001583003504 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1001583003505 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1001583003506 ATP binding site [chemical binding]; other site 1001583003507 putative Mg++ binding site [ion binding]; other site 1001583003508 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001583003509 nucleotide binding region [chemical binding]; other site 1001583003510 ATP-binding site [chemical binding]; other site 1001583003511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1001583003512 Predicted membrane protein [Function unknown]; Region: COG3601 1001583003513 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1001583003514 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1001583003515 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1001583003516 RNA binding surface [nucleotide binding]; other site 1001583003517 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1001583003518 active site 1001583003519 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 1001583003520 ScpA/B protein; Region: ScpA_ScpB; cl00598 1001583003521 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1001583003522 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1001583003523 active site 1001583003524 Int/Topo IB signature motif; other site 1001583003525 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1001583003526 S1 domain; Region: S1_2; pfam13509 1001583003527 pyruvate kinase; Provisional; Region: PRK06354 1001583003528 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1001583003529 domain interfaces; other site 1001583003530 active site 1001583003531 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1001583003532 putative translaldolase; Provisional; Region: PRK12376 1001583003533 catalytic residue [active] 1001583003534 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1001583003535 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1001583003536 active site 1001583003537 PHP Thumb interface [polypeptide binding]; other site 1001583003538 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1001583003539 generic binding surface II; other site 1001583003540 generic binding surface I; other site 1001583003541 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1001583003542 Clp amino terminal domain; Region: Clp_N; pfam02861 1001583003543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001583003544 Walker A motif; other site 1001583003545 ATP binding site [chemical binding]; other site 1001583003546 Walker B motif; other site 1001583003547 arginine finger; other site 1001583003548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001583003549 Walker A motif; other site 1001583003550 ATP binding site [chemical binding]; other site 1001583003551 Walker B motif; other site 1001583003552 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1001583003553 peptidase T; Region: peptidase-T; TIGR01882 1001583003554 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1001583003555 metal binding site [ion binding]; metal-binding site 1001583003556 dimer interface [polypeptide binding]; other site 1001583003557 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1001583003558 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1001583003559 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1001583003560 Family of unknown function (DUF633); Region: DUF633; pfam04816 1001583003561 MMPL family; Region: MMPL; pfam03176 1001583003562 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1001583003563 Predicted transcriptional regulator [Transcription]; Region: COG1959 1001583003564 Transcriptional regulator; Region: Rrf2; pfam02082 1001583003565 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1001583003566 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1001583003567 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1001583003568 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1001583003569 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1001583003570 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1001583003571 DNA binding residues [nucleotide binding] 1001583003572 DNA primase; Validated; Region: dnaG; PRK05667 1001583003573 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1001583003574 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1001583003575 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1001583003576 active site 1001583003577 metal binding site [ion binding]; metal-binding site 1001583003578 interdomain interaction site; other site 1001583003579 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1001583003580 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1001583003581 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1001583003582 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1001583003583 dimer interface [polypeptide binding]; other site 1001583003584 motif 1; other site 1001583003585 active site 1001583003586 motif 2; other site 1001583003587 motif 3; other site 1001583003588 DNA repair protein RecO; Region: reco; TIGR00613 1001583003589 Recombination protein O N terminal; Region: RecO_N; pfam11967 1001583003590 Recombination protein O C terminal; Region: RecO_C; pfam02565 1001583003591 GTPase Era; Reviewed; Region: era; PRK00089 1001583003592 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1001583003593 G1 box; other site 1001583003594 GTP/Mg2+ binding site [chemical binding]; other site 1001583003595 Switch I region; other site 1001583003596 G2 box; other site 1001583003597 Switch II region; other site 1001583003598 G3 box; other site 1001583003599 G4 box; other site 1001583003600 G5 box; other site 1001583003601 KH domain; Region: KH_2; pfam07650 1001583003602 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 1001583003603 metal-binding heat shock protein; Provisional; Region: PRK00016 1001583003604 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1001583003605 PhoH-like protein; Region: PhoH; pfam02562 1001583003606 Yqey-like protein; Region: YqeY; pfam09424 1001583003607 Predicted transcriptional regulators [Transcription]; Region: COG1733 1001583003608 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1001583003609 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1001583003610 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1001583003611 putative NAD(P) binding site [chemical binding]; other site 1001583003612 dimer interface [polypeptide binding]; other site 1001583003613 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 1001583003614 endonuclease IV; Provisional; Region: PRK01060 1001583003615 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1001583003616 AP (apurinic/apyrimidinic) site pocket; other site 1001583003617 DNA interaction; other site 1001583003618 Metal-binding active site; metal-binding site 1001583003619 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1001583003620 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1001583003621 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1001583003622 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1001583003623 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1001583003624 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1001583003625 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1001583003626 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1001583003627 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1001583003628 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 1001583003629 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1001583003630 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1001583003631 dimer interface [polypeptide binding]; other site 1001583003632 anticodon binding site; other site 1001583003633 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1001583003634 homodimer interface [polypeptide binding]; other site 1001583003635 motif 1; other site 1001583003636 active site 1001583003637 motif 2; other site 1001583003638 GAD domain; Region: GAD; pfam02938 1001583003639 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1001583003640 active site 1001583003641 motif 3; other site 1001583003642 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1001583003643 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1001583003644 dimer interface [polypeptide binding]; other site 1001583003645 motif 1; other site 1001583003646 active site 1001583003647 motif 2; other site 1001583003648 motif 3; other site 1001583003649 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1001583003650 anticodon binding site; other site 1001583003651 Bacterial SH3 domain; Region: SH3_3; pfam08239 1001583003652 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1001583003653 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1001583003654 active site 1001583003655 metal binding site [ion binding]; metal-binding site 1001583003656 Phosphotransferase enzyme family; Region: APH; pfam01636 1001583003657 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1001583003658 active site 1001583003659 ATP binding site [chemical binding]; other site 1001583003660 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1001583003661 substrate binding site [chemical binding]; other site 1001583003662 putative transposase OrfB; Reviewed; Region: PHA02517 1001583003663 HTH-like domain; Region: HTH_21; pfam13276 1001583003664 Integrase core domain; Region: rve; pfam00665 1001583003665 Integrase core domain; Region: rve_2; pfam13333 1001583003666 Helix-turn-helix domain; Region: HTH_28; pfam13518 1001583003667 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1001583003668 Transposase; Region: HTH_Tnp_1; cl17663 1001583003669 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1001583003670 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001583003671 motif II; other site 1001583003672 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1001583003673 putative active site [active] 1001583003674 dimerization interface [polypeptide binding]; other site 1001583003675 putative tRNAtyr binding site [nucleotide binding]; other site 1001583003676 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1001583003677 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1001583003678 Zn2+ binding site [ion binding]; other site 1001583003679 Mg2+ binding site [ion binding]; other site 1001583003680 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1001583003681 synthetase active site [active] 1001583003682 NTP binding site [chemical binding]; other site 1001583003683 metal binding site [ion binding]; metal-binding site 1001583003684 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1001583003685 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1001583003686 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1001583003687 RNA methyltransferase, RsmE family; Region: TIGR00046 1001583003688 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1001583003689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001583003690 S-adenosylmethionine binding site [chemical binding]; other site 1001583003691 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1001583003692 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1001583003693 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1001583003694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001583003695 S-adenosylmethionine binding site [chemical binding]; other site 1001583003696 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583003697 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583003698 Integrase core domain; Region: rve; pfam00665 1001583003699 GTP-binding protein LepA; Provisional; Region: PRK05433 1001583003700 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1001583003701 G1 box; other site 1001583003702 putative GEF interaction site [polypeptide binding]; other site 1001583003703 GTP/Mg2+ binding site [chemical binding]; other site 1001583003704 Switch I region; other site 1001583003705 G2 box; other site 1001583003706 G3 box; other site 1001583003707 Switch II region; other site 1001583003708 G4 box; other site 1001583003709 G5 box; other site 1001583003710 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1001583003711 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1001583003712 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1001583003713 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1001583003714 DltD N-terminal region; Region: DltD_N; pfam04915 1001583003715 DltD central region; Region: DltD_M; pfam04918 1001583003716 DltD C-terminal region; Region: DltD_C; pfam04914 1001583003717 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1001583003718 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1001583003719 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1001583003720 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1001583003721 acyl-activating enzyme (AAE) consensus motif; other site 1001583003722 AMP binding site [chemical binding]; other site 1001583003723 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1001583003724 chaperone protein DnaJ; Provisional; Region: PRK14276 1001583003725 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1001583003726 HSP70 interaction site [polypeptide binding]; other site 1001583003727 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1001583003728 substrate binding site [polypeptide binding]; other site 1001583003729 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1001583003730 Zn binding sites [ion binding]; other site 1001583003731 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1001583003732 dimer interface [polypeptide binding]; other site 1001583003733 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1001583003734 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1001583003735 nucleotide binding site [chemical binding]; other site 1001583003736 GrpE; Region: GrpE; pfam01025 1001583003737 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1001583003738 dimer interface [polypeptide binding]; other site 1001583003739 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1001583003740 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1001583003741 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1001583003742 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1001583003743 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1001583003744 active site 1001583003745 Riboflavin kinase; Region: Flavokinase; smart00904 1001583003746 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1001583003747 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1001583003748 RNA binding site [nucleotide binding]; other site 1001583003749 active site 1001583003750 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1001583003751 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1001583003752 translation initiation factor IF-2; Region: IF-2; TIGR00487 1001583003753 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1001583003754 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1001583003755 G1 box; other site 1001583003756 putative GEF interaction site [polypeptide binding]; other site 1001583003757 GTP/Mg2+ binding site [chemical binding]; other site 1001583003758 Switch I region; other site 1001583003759 G2 box; other site 1001583003760 G3 box; other site 1001583003761 Switch II region; other site 1001583003762 G4 box; other site 1001583003763 G5 box; other site 1001583003764 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1001583003765 Translation-initiation factor 2; Region: IF-2; pfam11987 1001583003766 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1001583003767 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1001583003768 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1001583003769 putative RNA binding cleft [nucleotide binding]; other site 1001583003770 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1001583003771 NusA N-terminal domain; Region: NusA_N; pfam08529 1001583003772 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1001583003773 RNA binding site [nucleotide binding]; other site 1001583003774 homodimer interface [polypeptide binding]; other site 1001583003775 NusA-like KH domain; Region: KH_5; pfam13184 1001583003776 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1001583003777 G-X-X-G motif; other site 1001583003778 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1001583003779 Sm and related proteins; Region: Sm_like; cl00259 1001583003780 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1001583003781 putative oligomer interface [polypeptide binding]; other site 1001583003782 putative RNA binding site [nucleotide binding]; other site 1001583003783 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1001583003784 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1001583003785 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1001583003786 generic binding surface II; other site 1001583003787 generic binding surface I; other site 1001583003788 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1001583003789 active site 1001583003790 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1001583003791 active site 1001583003792 catalytic site [active] 1001583003793 substrate binding site [chemical binding]; other site 1001583003794 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1001583003795 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1001583003796 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1001583003797 dimer interface [polypeptide binding]; other site 1001583003798 motif 1; other site 1001583003799 active site 1001583003800 motif 2; other site 1001583003801 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1001583003802 putative deacylase active site [active] 1001583003803 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1001583003804 active site 1001583003805 motif 3; other site 1001583003806 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1001583003807 anticodon binding site; other site 1001583003808 RIP metalloprotease RseP; Region: TIGR00054 1001583003809 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1001583003810 active site 1001583003811 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1001583003812 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1001583003813 protein binding site [polypeptide binding]; other site 1001583003814 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1001583003815 putative substrate binding region [chemical binding]; other site 1001583003816 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1001583003817 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1001583003818 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 1001583003819 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1001583003820 catalytic residue [active] 1001583003821 putative FPP diphosphate binding site; other site 1001583003822 putative FPP binding hydrophobic cleft; other site 1001583003823 dimer interface [polypeptide binding]; other site 1001583003824 putative IPP diphosphate binding site; other site 1001583003825 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1001583003826 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1001583003827 hinge region; other site 1001583003828 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1001583003829 putative nucleotide binding site [chemical binding]; other site 1001583003830 uridine monophosphate binding site [chemical binding]; other site 1001583003831 homohexameric interface [polypeptide binding]; other site 1001583003832 elongation factor Ts; Provisional; Region: tsf; PRK09377 1001583003833 UBA/TS-N domain; Region: UBA; pfam00627 1001583003834 Elongation factor TS; Region: EF_TS; pfam00889 1001583003835 Elongation factor TS; Region: EF_TS; pfam00889 1001583003836 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1001583003837 rRNA interaction site [nucleotide binding]; other site 1001583003838 S8 interaction site; other site 1001583003839 putative laminin-1 binding site; other site 1001583003840 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1001583003841 Integrase core domain; Region: rve; pfam00665 1001583003842 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1001583003843 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1001583003844 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001583003845 motif II; other site 1001583003846 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1001583003847 D-lactate dehydrogenase; Validated; Region: PRK08605 1001583003848 homodimer interface [polypeptide binding]; other site 1001583003849 ligand binding site [chemical binding]; other site 1001583003850 NAD binding site [chemical binding]; other site 1001583003851 catalytic site [active] 1001583003852 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1001583003853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001583003854 S-adenosylmethionine binding site [chemical binding]; other site 1001583003855 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1001583003856 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1001583003857 putative acyl-acceptor binding pocket; other site 1001583003858 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1001583003859 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1001583003860 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1001583003861 Walker A/P-loop; other site 1001583003862 ATP binding site [chemical binding]; other site 1001583003863 Q-loop/lid; other site 1001583003864 ABC transporter signature motif; other site 1001583003865 Walker B; other site 1001583003866 D-loop; other site 1001583003867 H-loop/switch region; other site 1001583003868 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1001583003869 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001583003870 Q-loop/lid; other site 1001583003871 ABC transporter signature motif; other site 1001583003872 Walker B; other site 1001583003873 D-loop; other site 1001583003874 H-loop/switch region; other site 1001583003875 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1001583003876 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1001583003877 Walker A/P-loop; other site 1001583003878 ATP binding site [chemical binding]; other site 1001583003879 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1001583003880 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1001583003881 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001583003882 putative DNA binding site [nucleotide binding]; other site 1001583003883 LexA repressor; Validated; Region: PRK00215 1001583003884 putative Zn2+ binding site [ion binding]; other site 1001583003885 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1001583003886 Catalytic site [active] 1001583003887 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1001583003888 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1001583003889 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1001583003890 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1001583003891 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1001583003892 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1001583003893 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1001583003894 dimer interface [polypeptide binding]; other site 1001583003895 active site 1001583003896 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1001583003897 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1001583003898 catalytic core [active] 1001583003899 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1001583003900 PspC domain; Region: PspC; pfam04024 1001583003901 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1001583003902 active site 1001583003903 multimer interface [polypeptide binding]; other site 1001583003904 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 1001583003905 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1001583003906 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1001583003907 CsbD-like; Region: CsbD; pfam05532 1001583003908 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1001583003909 Ligand Binding Site [chemical binding]; other site 1001583003910 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001583003911 active site 1001583003912 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1001583003913 DHH family; Region: DHH; pfam01368 1001583003914 DHHA1 domain; Region: DHHA1; pfam02272 1001583003915 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 1001583003916 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 1001583003917 ribonuclease Z; Region: RNase_Z; TIGR02651 1001583003918 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1001583003919 GTP1/OBG; Region: GTP1_OBG; pfam01018 1001583003920 Obg GTPase; Region: Obg; cd01898 1001583003921 G1 box; other site 1001583003922 GTP/Mg2+ binding site [chemical binding]; other site 1001583003923 Switch I region; other site 1001583003924 G2 box; other site 1001583003925 G3 box; other site 1001583003926 Switch II region; other site 1001583003927 G4 box; other site 1001583003928 G5 box; other site 1001583003929 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1001583003930 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1001583003931 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1001583003932 GIY-YIG motif/motif A; other site 1001583003933 active site 1001583003934 catalytic site [active] 1001583003935 putative DNA binding site [nucleotide binding]; other site 1001583003936 metal binding site [ion binding]; metal-binding site 1001583003937 UvrB/uvrC motif; Region: UVR; pfam02151 1001583003938 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1001583003939 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1001583003940 DNA binding site [nucleotide binding] 1001583003941 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 1001583003942 putative metal binding site [ion binding]; other site 1001583003943 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1001583003944 G1 box; other site 1001583003945 GTP/Mg2+ binding site [chemical binding]; other site 1001583003946 Switch I region; other site 1001583003947 G2 box; other site 1001583003948 G3 box; other site 1001583003949 Switch II region; other site 1001583003950 G4 box; other site 1001583003951 G5 box; other site 1001583003952 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1001583003953 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1001583003954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001583003955 Walker A motif; other site 1001583003956 ATP binding site [chemical binding]; other site 1001583003957 Walker B motif; other site 1001583003958 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1001583003959 trigger factor; Provisional; Region: tig; PRK01490 1001583003960 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1001583003961 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1001583003962 elongation factor Tu; Reviewed; Region: PRK12736 1001583003963 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1001583003964 G1 box; other site 1001583003965 GEF interaction site [polypeptide binding]; other site 1001583003966 GTP/Mg2+ binding site [chemical binding]; other site 1001583003967 Switch I region; other site 1001583003968 G2 box; other site 1001583003969 G3 box; other site 1001583003970 Switch II region; other site 1001583003971 G4 box; other site 1001583003972 G5 box; other site 1001583003973 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1001583003974 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1001583003975 Antibiotic Binding Site [chemical binding]; other site 1001583003976 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1001583003977 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1001583003978 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1001583003979 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1001583003980 16S/18S rRNA binding site [nucleotide binding]; other site 1001583003981 S13e-L30e interaction site [polypeptide binding]; other site 1001583003982 25S rRNA binding site [nucleotide binding]; other site 1001583003983 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1001583003984 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1001583003985 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1001583003986 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1001583003987 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1001583003988 Competence protein; Region: Competence; pfam03772 1001583003989 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1001583003990 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1001583003991 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1001583003992 catalytic motif [active] 1001583003993 Zn binding site [ion binding]; other site 1001583003994 SLBB domain; Region: SLBB; pfam10531 1001583003995 comEA protein; Region: comE; TIGR01259 1001583003996 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1001583003997 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1001583003998 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1001583003999 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1001583004000 active site 1001583004001 (T/H)XGH motif; other site 1001583004002 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1001583004003 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001583004004 S-adenosylmethionine binding site [chemical binding]; other site 1001583004005 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 1001583004006 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1001583004007 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1001583004008 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1001583004009 putative GEF interaction site [polypeptide binding]; other site 1001583004010 G1 box; other site 1001583004011 GTP/Mg2+ binding site [chemical binding]; other site 1001583004012 Switch I region; other site 1001583004013 G2 box; other site 1001583004014 G3 box; other site 1001583004015 Switch II region; other site 1001583004016 G4 box; other site 1001583004017 G5 box; other site 1001583004018 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1001583004019 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1001583004020 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1001583004021 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1001583004022 active site 1001583004023 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 1001583004024 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1001583004025 substrate binding site [chemical binding]; other site 1001583004026 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1001583004027 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1001583004028 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001583004029 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1001583004030 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1001583004031 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1001583004032 E3 interaction surface; other site 1001583004033 lipoyl attachment site [posttranslational modification]; other site 1001583004034 e3 binding domain; Region: E3_binding; pfam02817 1001583004035 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1001583004036 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1001583004037 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1001583004038 alpha subunit interface [polypeptide binding]; other site 1001583004039 TPP binding site [chemical binding]; other site 1001583004040 heterodimer interface [polypeptide binding]; other site 1001583004041 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1001583004042 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1001583004043 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1001583004044 TPP-binding site [chemical binding]; other site 1001583004045 tetramer interface [polypeptide binding]; other site 1001583004046 heterodimer interface [polypeptide binding]; other site 1001583004047 phosphorylation loop region [posttranslational modification] 1001583004048 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1001583004049 active site 1001583004050 catalytic residues [active] 1001583004051 metal binding site [ion binding]; metal-binding site 1001583004052 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 1001583004053 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1001583004054 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1001583004055 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1001583004056 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1001583004057 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1001583004058 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001583004059 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1001583004060 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001583004061 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1001583004062 NlpC/P60 family; Region: NLPC_P60; pfam00877 1001583004063 Predicted secreted protein [Function unknown]; Region: COG4086 1001583004064 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1001583004065 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1001583004066 NlpC/P60 family; Region: NLPC_P60; pfam00877 1001583004067 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1001583004068 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1001583004069 TPP-binding site [chemical binding]; other site 1001583004070 dimer interface [polypeptide binding]; other site 1001583004071 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1001583004072 PYR/PP interface [polypeptide binding]; other site 1001583004073 dimer interface [polypeptide binding]; other site 1001583004074 TPP binding site [chemical binding]; other site 1001583004075 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1001583004076 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1001583004077 substrate binding site [chemical binding]; other site 1001583004078 dimer interface [polypeptide binding]; other site 1001583004079 ATP binding site [chemical binding]; other site 1001583004080 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1001583004081 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1001583004082 DNA binding site [nucleotide binding] 1001583004083 domain linker motif; other site 1001583004084 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1001583004085 dimerization interface [polypeptide binding]; other site 1001583004086 ligand binding site [chemical binding]; other site 1001583004087 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1001583004088 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1001583004089 active site 1001583004090 catalytic tetrad [active] 1001583004091 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1001583004092 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1001583004093 putative active site [active] 1001583004094 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1001583004095 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1001583004096 peptide binding site [polypeptide binding]; other site 1001583004097 Amidase; Region: Amidase; cl11426 1001583004098 Amidase; Region: Amidase; cl11426 1001583004099 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1001583004100 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1001583004101 substrate binding pocket [chemical binding]; other site 1001583004102 membrane-bound complex binding site; other site 1001583004103 hinge residues; other site 1001583004104 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1001583004105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001583004106 dimer interface [polypeptide binding]; other site 1001583004107 conserved gate region; other site 1001583004108 putative PBP binding loops; other site 1001583004109 ABC-ATPase subunit interface; other site 1001583004110 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1001583004111 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1001583004112 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1001583004113 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001583004114 active site 1001583004115 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1001583004116 AAA domain; Region: AAA_30; pfam13604 1001583004117 Family description; Region: UvrD_C_2; pfam13538 1001583004118 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1001583004119 binding surface 1001583004120 TPR motif; other site 1001583004121 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1001583004122 binding surface 1001583004123 TPR motif; other site 1001583004124 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1001583004125 catalytic core [active] 1001583004126 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1001583004127 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1001583004128 Putative amino acid metabolism; Region: DUF1831; pfam08866 1001583004129 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1001583004130 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1001583004131 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1001583004132 catalytic residue [active] 1001583004133 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1001583004134 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1001583004135 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1001583004136 dimer interface [polypeptide binding]; other site 1001583004137 ADP-ribose binding site [chemical binding]; other site 1001583004138 active site 1001583004139 nudix motif; other site 1001583004140 metal binding site [ion binding]; metal-binding site 1001583004141 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1001583004142 DNA-binding site [nucleotide binding]; DNA binding site 1001583004143 RNA-binding motif; other site 1001583004144 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1001583004145 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1001583004146 active site 1001583004147 HIGH motif; other site 1001583004148 nucleotide binding site [chemical binding]; other site 1001583004149 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1001583004150 active site 1001583004151 KMSKS motif; other site 1001583004152 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1001583004153 tRNA binding surface [nucleotide binding]; other site 1001583004154 anticodon binding site; other site 1001583004155 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1001583004156 DivIVA protein; Region: DivIVA; pfam05103 1001583004157 DivIVA domain; Region: DivI1A_domain; TIGR03544 1001583004158 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1001583004159 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1001583004160 RNA binding surface [nucleotide binding]; other site 1001583004161 YGGT family; Region: YGGT; pfam02325 1001583004162 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1001583004163 cell division protein FtsZ; Validated; Region: PRK09330 1001583004164 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1001583004165 nucleotide binding site [chemical binding]; other site 1001583004166 SulA interaction site; other site 1001583004167 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1001583004168 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1001583004169 nucleotide binding site [chemical binding]; other site 1001583004170 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 1001583004171 Cell division protein FtsA; Region: FtsA; pfam14450 1001583004172 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 1001583004173 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1001583004174 Cell division protein FtsQ; Region: FtsQ; pfam03799 1001583004175 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1001583004176 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1001583004177 active site 1001583004178 homodimer interface [polypeptide binding]; other site 1001583004179 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1001583004180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001583004181 S-adenosylmethionine binding site [chemical binding]; other site 1001583004182 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1001583004183 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1001583004184 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1001583004185 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1001583004186 Mg++ binding site [ion binding]; other site 1001583004187 putative catalytic motif [active] 1001583004188 putative substrate binding site [chemical binding]; other site 1001583004189 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1001583004190 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1001583004191 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1001583004192 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1001583004193 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1001583004194 Cell division protein FtsL; Region: FtsL; cl11433 1001583004195 MraW methylase family; Region: Methyltransf_5; pfam01795 1001583004196 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1001583004197 cell division protein MraZ; Reviewed; Region: PRK00326 1001583004198 MraZ protein; Region: MraZ; pfam02381 1001583004199 MraZ protein; Region: MraZ; pfam02381 1001583004200 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 1001583004201 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 1001583004202 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1001583004203 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1001583004204 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1001583004205 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1001583004206 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1001583004207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001583004208 S-adenosylmethionine binding site [chemical binding]; other site 1001583004209 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1001583004210 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1001583004211 CutC family; Region: CutC; cl01218 1001583004212 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1001583004213 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1001583004214 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1001583004215 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1001583004216 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1001583004217 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1001583004218 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583004219 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583004220 Integrase core domain; Region: rve; pfam00665 1001583004221 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1001583004222 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1001583004223 active site 1001583004224 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1001583004225 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1001583004226 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1001583004227 synthetase active site [active] 1001583004228 NTP binding site [chemical binding]; other site 1001583004229 metal binding site [ion binding]; metal-binding site 1001583004230 Thioredoxin; Region: Thioredoxin_5; pfam13743 1001583004231 EDD domain protein, DegV family; Region: DegV; TIGR00762 1001583004232 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1001583004233 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 1001583004234 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1001583004235 active site 1001583004236 Zn binding site [ion binding]; other site 1001583004237 Competence protein CoiA-like family; Region: CoiA; cl11541 1001583004238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001583004239 S-adenosylmethionine binding site [chemical binding]; other site 1001583004240 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 1001583004241 Phosphotransferase enzyme family; Region: APH; pfam01636 1001583004242 substrate binding site [chemical binding]; other site 1001583004243 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1001583004244 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1001583004245 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1001583004246 Walker A/P-loop; other site 1001583004247 ATP binding site [chemical binding]; other site 1001583004248 Q-loop/lid; other site 1001583004249 ABC transporter signature motif; other site 1001583004250 Walker B; other site 1001583004251 D-loop; other site 1001583004252 H-loop/switch region; other site 1001583004253 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1001583004254 HIT family signature motif; other site 1001583004255 catalytic residue [active] 1001583004256 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1001583004257 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1001583004258 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1001583004259 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1001583004260 generic binding surface II; other site 1001583004261 generic binding surface I; other site 1001583004262 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 1001583004263 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1001583004264 Zn2+ binding site [ion binding]; other site 1001583004265 Mg2+ binding site [ion binding]; other site 1001583004266 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001583004267 Walker A/P-loop; other site 1001583004268 ATP binding site [chemical binding]; other site 1001583004269 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1001583004270 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1001583004271 active site 1001583004272 metal binding site [ion binding]; metal-binding site 1001583004273 DNA binding site [nucleotide binding] 1001583004274 Protein of unknown function (DUF964); Region: DUF964; cl01483 1001583004275 Transglycosylase; Region: Transgly; pfam00912 1001583004276 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1001583004277 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1001583004278 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1001583004279 Arginine repressor [Transcription]; Region: ArgR; COG1438 1001583004280 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1001583004281 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1001583004282 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1001583004283 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1001583004284 active site 1001583004285 HIGH motif; other site 1001583004286 KMSK motif region; other site 1001583004287 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1001583004288 tRNA binding surface [nucleotide binding]; other site 1001583004289 anticodon binding site; other site 1001583004290 DNA helicase, putative; Region: TIGR00376 1001583004291 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1001583004292 amidase catalytic site [active] 1001583004293 Zn binding residues [ion binding]; other site 1001583004294 substrate binding site [chemical binding]; other site 1001583004295 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1001583004296 RibD C-terminal domain; Region: RibD_C; cl17279 1001583004297 Protein of unknown function (DUF1516); Region: DUF1516; pfam07457 1001583004298 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583004299 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583004300 Integrase core domain; Region: rve; pfam00665 1001583004301 aspartate racemase; Region: asp_race; TIGR00035 1001583004302 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1001583004303 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 1001583004304 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1001583004305 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1001583004306 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1001583004307 active site 1001583004308 dimer interface [polypeptide binding]; other site 1001583004309 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1001583004310 Ligand Binding Site [chemical binding]; other site 1001583004311 Molecular Tunnel; other site 1001583004312 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1001583004313 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1001583004314 ligand binding site [chemical binding]; other site 1001583004315 flexible hinge region; other site 1001583004316 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1001583004317 putative switch regulator; other site 1001583004318 non-specific DNA interactions [nucleotide binding]; other site 1001583004319 DNA binding site [nucleotide binding] 1001583004320 sequence specific DNA binding site [nucleotide binding]; other site 1001583004321 putative cAMP binding site [chemical binding]; other site 1001583004322 Peptidase family C69; Region: Peptidase_C69; pfam03577 1001583004323 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001583004324 Walker A/P-loop; other site 1001583004325 ATP binding site [chemical binding]; other site 1001583004326 Q-loop/lid; other site 1001583004327 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1001583004328 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1001583004329 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001583004330 ABC transporter signature motif; other site 1001583004331 Walker B; other site 1001583004332 D-loop; other site 1001583004333 H-loop/switch region; other site 1001583004334 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001583004335 Walker A/P-loop; other site 1001583004336 ATP binding site [chemical binding]; other site 1001583004337 Q-loop/lid; other site 1001583004338 ABC transporter signature motif; other site 1001583004339 Walker B; other site 1001583004340 D-loop; other site 1001583004341 H-loop/switch region; other site 1001583004342 putative transposase OrfB; Reviewed; Region: PHA02517 1001583004343 HTH-like domain; Region: HTH_21; pfam13276 1001583004344 Integrase core domain; Region: rve; pfam00665 1001583004345 Integrase core domain; Region: rve_2; pfam13333 1001583004346 Helix-turn-helix domain; Region: HTH_28; pfam13518 1001583004347 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1001583004348 Transposase; Region: HTH_Tnp_1; cl17663 1001583004349 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 1001583004350 VanZ like family; Region: VanZ; cl01971 1001583004351 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001583004352 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001583004353 putative DNA binding site [nucleotide binding]; other site 1001583004354 putative Zn2+ binding site [ion binding]; other site 1001583004355 MarR family; Region: MarR_2; cl17246 1001583004356 CAAX protease self-immunity; Region: Abi; pfam02517 1001583004357 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 1001583004358 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1001583004359 putative ligand binding site [chemical binding]; other site 1001583004360 putative NAD binding site [chemical binding]; other site 1001583004361 catalytic site [active] 1001583004362 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1001583004363 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1001583004364 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1001583004365 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1001583004366 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1001583004367 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001583004368 motif II; other site 1001583004369 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1001583004370 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001583004371 active site 1001583004372 motif I; other site 1001583004373 motif II; other site 1001583004374 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1001583004375 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1001583004376 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1001583004377 Substrate-binding site [chemical binding]; other site 1001583004378 Substrate specificity [chemical binding]; other site 1001583004379 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 1001583004380 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1001583004381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583004382 putative substrate translocation pore; other site 1001583004383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583004384 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1001583004385 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1001583004386 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1001583004387 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1001583004388 hypothetical protein; Provisional; Region: PRK00967 1001583004389 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1001583004390 active site 1001583004391 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1001583004392 Ligand Binding Site [chemical binding]; other site 1001583004393 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1001583004394 Sulfatase; Region: Sulfatase; pfam00884 1001583004395 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 1001583004396 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1001583004397 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1001583004398 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1001583004399 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1001583004400 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1001583004401 putative ADP-binding pocket [chemical binding]; other site 1001583004402 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1001583004403 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1001583004404 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1001583004405 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1001583004406 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1001583004407 dimerization domain swap beta strand [polypeptide binding]; other site 1001583004408 regulatory protein interface [polypeptide binding]; other site 1001583004409 active site 1001583004410 regulatory phosphorylation site [posttranslational modification]; other site 1001583004411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001583004412 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1001583004413 Walker A motif; other site 1001583004414 ATP binding site [chemical binding]; other site 1001583004415 Walker B motif; other site 1001583004416 arginine finger; other site 1001583004417 endopeptidase Clp ATP-binding regulatory subunit (clpX); Region: clpX; TIGR00382 1001583004418 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001583004419 Walker A motif; other site 1001583004420 ATP binding site [chemical binding]; other site 1001583004421 Walker B motif; other site 1001583004422 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1001583004423 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1001583004424 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1001583004425 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1001583004426 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1001583004427 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1001583004428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001583004429 motif II; other site 1001583004430 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1001583004431 Peptidase family C69; Region: Peptidase_C69; pfam03577 1001583004432 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 1001583004433 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1001583004434 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1001583004435 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001583004436 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1001583004437 legume lectins; Region: lectin_L-type; cd01951 1001583004438 homotetramer interaction site [polypeptide binding]; other site 1001583004439 carbohydrate binding site [chemical binding]; other site 1001583004440 metal binding site [ion binding]; metal-binding site 1001583004441 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1001583004442 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1001583004443 G1 box; other site 1001583004444 putative GEF interaction site [polypeptide binding]; other site 1001583004445 GTP/Mg2+ binding site [chemical binding]; other site 1001583004446 Switch I region; other site 1001583004447 G2 box; other site 1001583004448 G3 box; other site 1001583004449 Switch II region; other site 1001583004450 G4 box; other site 1001583004451 G5 box; other site 1001583004452 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1001583004453 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1001583004454 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1001583004455 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1001583004456 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1001583004457 active site 1001583004458 nucleotide binding site [chemical binding]; other site 1001583004459 HIGH motif; other site 1001583004460 KMSKS motif; other site 1001583004461 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1001583004462 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1001583004463 hypothetical protein; Provisional; Region: PRK13662 1001583004464 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1001583004465 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1001583004466 Beta-lactamase; Region: Beta-lactamase; pfam00144 1001583004467 recombination regulator RecX; Provisional; Region: recX; PRK14135 1001583004468 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1001583004469 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1001583004470 Nuclease-related domain; Region: NERD; pfam08378 1001583004471 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1001583004472 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1001583004473 active site 1001583004474 homodimer interface [polypeptide binding]; other site 1001583004475 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1001583004476 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1001583004477 Ligand binding site; other site 1001583004478 Putative Catalytic site; other site 1001583004479 DXD motif; other site 1001583004480 GntP family permease; Region: GntP_permease; pfam02447 1001583004481 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1001583004482 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1001583004483 Ligand Binding Site [chemical binding]; other site 1001583004484 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1001583004485 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1001583004486 ATP binding site [chemical binding]; other site 1001583004487 putative Mg++ binding site [ion binding]; other site 1001583004488 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001583004489 nucleotide binding region [chemical binding]; other site 1001583004490 ATP-binding site [chemical binding]; other site 1001583004491 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1001583004492 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1001583004493 EIAV coat protein, gp90; Region: EIAV_GP90; pfam00971 1001583004494 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419 1001583004495 active site 1001583004496 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1001583004497 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1001583004498 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1001583004499 putative active site [active] 1001583004500 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1001583004501 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1001583004502 N- and C-terminal domain interface [polypeptide binding]; other site 1001583004503 active site 1001583004504 catalytic site [active] 1001583004505 metal binding site [ion binding]; metal-binding site 1001583004506 carbohydrate binding site [chemical binding]; other site 1001583004507 ATP binding site [chemical binding]; other site 1001583004508 GntP family permease; Region: GntP_permease; pfam02447 1001583004509 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1001583004510 Amino acid permease; Region: AA_permease_2; pfam13520 1001583004511 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1001583004512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583004513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583004514 D-ribose pyranase; Provisional; Region: PRK11797 1001583004515 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1001583004516 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1001583004517 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1001583004518 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1001583004519 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1001583004520 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1001583004521 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1001583004522 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1001583004523 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1001583004524 phosphopentomutase; Provisional; Region: PRK05362 1001583004525 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1001583004526 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1001583004527 intersubunit interface [polypeptide binding]; other site 1001583004528 active site 1001583004529 catalytic residue [active] 1001583004530 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1001583004531 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001583004532 non-specific DNA binding site [nucleotide binding]; other site 1001583004533 salt bridge; other site 1001583004534 sequence-specific DNA binding site [nucleotide binding]; other site 1001583004535 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001583004536 sequence-specific DNA binding site [nucleotide binding]; other site 1001583004537 salt bridge; other site 1001583004538 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1001583004539 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1001583004540 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1001583004541 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1001583004542 phosphate binding site [ion binding]; other site 1001583004543 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 1001583004544 putative hexamer interface [polypeptide binding]; other site 1001583004545 putative hexagonal pore; other site 1001583004546 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1001583004547 propionate/acetate kinase; Provisional; Region: PRK12379 1001583004548 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1001583004549 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 1001583004550 putative active site [active] 1001583004551 metal binding site [ion binding]; metal-binding site 1001583004552 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1001583004553 putative catalytic cysteine [active] 1001583004554 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 1001583004555 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1001583004556 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1001583004557 Hexamer/Pentamer interface [polypeptide binding]; other site 1001583004558 central pore; other site 1001583004559 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 1001583004560 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 1001583004561 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1001583004562 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1001583004563 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1001583004564 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1001583004565 Hexamer interface [polypeptide binding]; other site 1001583004566 Hexagonal pore residue; other site 1001583004567 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1001583004568 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 1001583004569 putative hexamer interface [polypeptide binding]; other site 1001583004570 putative hexagonal pore; other site 1001583004571 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 1001583004572 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1001583004573 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 1001583004574 Dehydratase small subunit; Region: Dehydratase_SU; pfam02287 1001583004575 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 1001583004576 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 1001583004577 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 1001583004578 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 1001583004579 alpha-beta subunit interface [polypeptide binding]; other site 1001583004580 alpha-gamma subunit interface [polypeptide binding]; other site 1001583004581 active site 1001583004582 substrate and K+ binding site; other site 1001583004583 K+ binding site [ion binding]; other site 1001583004584 cobalamin binding site [chemical binding]; other site 1001583004585 propanediol utilization protein PduB; Provisional; Region: PRK15415 1001583004586 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 1001583004587 putative hexamer interface [polypeptide binding]; other site 1001583004588 putative hexagonal pore; other site 1001583004589 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 1001583004590 putative hexamer interface [polypeptide binding]; other site 1001583004591 putative hexagonal pore; other site 1001583004592 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1001583004593 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1001583004594 Hexamer interface [polypeptide binding]; other site 1001583004595 Putative hexagonal pore residue; other site 1001583004596 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1001583004597 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1001583004598 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1001583004599 amphipathic channel; other site 1001583004600 Asn-Pro-Ala signature motifs; other site 1001583004601 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1001583004602 G1 box; other site 1001583004603 GTP/Mg2+ binding site [chemical binding]; other site 1001583004604 G3 box; other site 1001583004605 Switch II region; other site 1001583004606 G4 box; other site 1001583004607 G5 box; other site 1001583004608 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1001583004609 TRAM domain; Region: TRAM; pfam01938 1001583004610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001583004611 S-adenosylmethionine binding site [chemical binding]; other site 1001583004612 putative lipid kinase; Reviewed; Region: PRK13055 1001583004613 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1001583004614 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1001583004615 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1001583004616 GatB domain; Region: GatB_Yqey; smart00845 1001583004617 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1001583004618 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1001583004619 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1001583004620 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1001583004621 putative dimer interface [polypeptide binding]; other site 1001583004622 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 1001583004623 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1001583004624 putative dimer interface [polypeptide binding]; other site 1001583004625 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1001583004626 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1001583004627 nucleotide binding pocket [chemical binding]; other site 1001583004628 K-X-D-G motif; other site 1001583004629 catalytic site [active] 1001583004630 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1001583004631 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1001583004632 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1001583004633 Dimer interface [polypeptide binding]; other site 1001583004634 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1001583004635 Part of AAA domain; Region: AAA_19; pfam13245 1001583004636 Family description; Region: UvrD_C_2; pfam13538 1001583004637 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1001583004638 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1001583004639 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001583004640 active site 1001583004641 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1001583004642 UbiA prenyltransferase family; Region: UbiA; pfam01040 1001583004643 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1001583004644 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1001583004645 substrate binding pocket [chemical binding]; other site 1001583004646 chain length determination region; other site 1001583004647 substrate-Mg2+ binding site; other site 1001583004648 catalytic residues [active] 1001583004649 aspartate-rich region 1; other site 1001583004650 active site lid residues [active] 1001583004651 aspartate-rich region 2; other site 1001583004652 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1001583004653 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1001583004654 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1001583004655 Walker A/P-loop; other site 1001583004656 ATP binding site [chemical binding]; other site 1001583004657 Q-loop/lid; other site 1001583004658 ABC transporter signature motif; other site 1001583004659 Walker B; other site 1001583004660 D-loop; other site 1001583004661 H-loop/switch region; other site 1001583004662 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1001583004663 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1001583004664 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001583004665 Walker A/P-loop; other site 1001583004666 ATP binding site [chemical binding]; other site 1001583004667 Q-loop/lid; other site 1001583004668 ABC transporter signature motif; other site 1001583004669 Walker B; other site 1001583004670 D-loop; other site 1001583004671 H-loop/switch region; other site 1001583004672 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1001583004673 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1001583004674 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1001583004675 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583004676 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583004677 Homeodomain-like domain; Region: HTH_32; pfam13565 1001583004678 Integrase core domain; Region: rve; pfam00665 1001583004679 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 1001583004680 putative ligand binding site [chemical binding]; other site 1001583004681 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1001583004682 NAD binding site [chemical binding]; other site 1001583004683 catalytic site [active] 1001583004684 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1001583004685 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1001583004686 NAD binding site [chemical binding]; other site 1001583004687 substrate binding site [chemical binding]; other site 1001583004688 homodimer interface [polypeptide binding]; other site 1001583004689 active site 1001583004690 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1001583004691 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1001583004692 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1001583004693 NADP binding site [chemical binding]; other site 1001583004694 active site 1001583004695 putative substrate binding site [chemical binding]; other site 1001583004696 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1001583004697 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1001583004698 NAD binding site [chemical binding]; other site 1001583004699 substrate binding site [chemical binding]; other site 1001583004700 homodimer interface [polypeptide binding]; other site 1001583004701 active site 1001583004702 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1001583004703 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1001583004704 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1001583004705 substrate binding site; other site 1001583004706 tetramer interface; other site 1001583004707 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1001583004708 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1001583004709 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 1001583004710 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1001583004711 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1001583004712 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1001583004713 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 1001583004714 Probable Catalytic site; other site 1001583004715 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1001583004716 active site 1001583004717 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1001583004718 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1001583004719 Probable Catalytic site; other site 1001583004720 metal-binding site 1001583004721 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1001583004722 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1001583004723 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1001583004724 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1001583004725 active site 1001583004726 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1001583004727 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1001583004728 Chain length determinant protein; Region: Wzz; cl15801 1001583004729 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1001583004730 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1001583004731 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1001583004732 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1001583004733 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1001583004734 amino acid transporter; Region: 2A0306; TIGR00909 1001583004735 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1001583004736 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1001583004737 dimer interface [polypeptide binding]; other site 1001583004738 active site 1001583004739 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1001583004740 homopentamer interface [polypeptide binding]; other site 1001583004741 active site 1001583004742 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1001583004743 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1001583004744 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1001583004745 dimerization interface [polypeptide binding]; other site 1001583004746 active site 1001583004747 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1001583004748 Lumazine binding domain; Region: Lum_binding; pfam00677 1001583004749 Lumazine binding domain; Region: Lum_binding; pfam00677 1001583004750 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1001583004751 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1001583004752 catalytic motif [active] 1001583004753 Zn binding site [ion binding]; other site 1001583004754 RibD C-terminal domain; Region: RibD_C; cl17279 1001583004755 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1001583004756 TrkA-N domain; Region: TrkA_N; pfam02254 1001583004757 TrkA-C domain; Region: TrkA_C; pfam02080 1001583004758 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1001583004759 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1001583004760 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1001583004761 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1001583004762 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1001583004763 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1001583004764 23S rRNA interface [nucleotide binding]; other site 1001583004765 L3 interface [polypeptide binding]; other site 1001583004766 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1001583004767 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1001583004768 dimerization interface 3.5A [polypeptide binding]; other site 1001583004769 active site 1001583004770 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1001583004771 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1001583004772 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1001583004773 Walker A/P-loop; other site 1001583004774 ATP binding site [chemical binding]; other site 1001583004775 Q-loop/lid; other site 1001583004776 ABC transporter signature motif; other site 1001583004777 Walker B; other site 1001583004778 D-loop; other site 1001583004779 H-loop/switch region; other site 1001583004780 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1001583004781 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1001583004782 Walker A/P-loop; other site 1001583004783 ATP binding site [chemical binding]; other site 1001583004784 Q-loop/lid; other site 1001583004785 ABC transporter signature motif; other site 1001583004786 Walker B; other site 1001583004787 D-loop; other site 1001583004788 H-loop/switch region; other site 1001583004789 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1001583004790 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1001583004791 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1001583004792 alphaNTD homodimer interface [polypeptide binding]; other site 1001583004793 alphaNTD - beta interaction site [polypeptide binding]; other site 1001583004794 alphaNTD - beta' interaction site [polypeptide binding]; other site 1001583004795 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1001583004796 30S ribosomal protein S11; Validated; Region: PRK05309 1001583004797 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1001583004798 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1001583004799 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1001583004800 rRNA binding site [nucleotide binding]; other site 1001583004801 predicted 30S ribosome binding site; other site 1001583004802 adenylate kinase; Reviewed; Region: adk; PRK00279 1001583004803 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1001583004804 AMP-binding site [chemical binding]; other site 1001583004805 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1001583004806 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1001583004807 SecY translocase; Region: SecY; pfam00344 1001583004808 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1001583004809 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1001583004810 23S rRNA binding site [nucleotide binding]; other site 1001583004811 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1001583004812 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1001583004813 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1001583004814 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1001583004815 5S rRNA interface [nucleotide binding]; other site 1001583004816 L27 interface [polypeptide binding]; other site 1001583004817 23S rRNA interface [nucleotide binding]; other site 1001583004818 L5 interface [polypeptide binding]; other site 1001583004819 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1001583004820 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1001583004821 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1001583004822 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1001583004823 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1001583004824 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1001583004825 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1001583004826 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1001583004827 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1001583004828 RNA binding site [nucleotide binding]; other site 1001583004829 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1001583004830 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1001583004831 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1001583004832 23S rRNA interface [nucleotide binding]; other site 1001583004833 putative translocon interaction site; other site 1001583004834 signal recognition particle (SRP54) interaction site; other site 1001583004835 L23 interface [polypeptide binding]; other site 1001583004836 trigger factor interaction site; other site 1001583004837 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1001583004838 23S rRNA interface [nucleotide binding]; other site 1001583004839 5S rRNA interface [nucleotide binding]; other site 1001583004840 putative antibiotic binding site [chemical binding]; other site 1001583004841 L25 interface [polypeptide binding]; other site 1001583004842 L27 interface [polypeptide binding]; other site 1001583004843 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1001583004844 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1001583004845 G-X-X-G motif; other site 1001583004846 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1001583004847 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1001583004848 putative translocon binding site; other site 1001583004849 protein-rRNA interface [nucleotide binding]; other site 1001583004850 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1001583004851 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1001583004852 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1001583004853 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1001583004854 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1001583004855 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1001583004856 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1001583004857 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1001583004858 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1001583004859 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1001583004860 elongation factor G; Reviewed; Region: PRK12739 1001583004861 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1001583004862 G1 box; other site 1001583004863 putative GEF interaction site [polypeptide binding]; other site 1001583004864 GTP/Mg2+ binding site [chemical binding]; other site 1001583004865 Switch I region; other site 1001583004866 G2 box; other site 1001583004867 G3 box; other site 1001583004868 Switch II region; other site 1001583004869 G4 box; other site 1001583004870 G5 box; other site 1001583004871 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1001583004872 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1001583004873 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1001583004874 30S ribosomal protein S7; Validated; Region: PRK05302 1001583004875 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1001583004876 S17 interaction site [polypeptide binding]; other site 1001583004877 S8 interaction site; other site 1001583004878 16S rRNA interaction site [nucleotide binding]; other site 1001583004879 streptomycin interaction site [chemical binding]; other site 1001583004880 23S rRNA interaction site [nucleotide binding]; other site 1001583004881 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1001583004882 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1001583004883 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1001583004884 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1001583004885 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1001583004886 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1001583004887 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1001583004888 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1001583004889 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1001583004890 cleft; other site 1001583004891 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 1001583004892 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1001583004893 DNA binding site [nucleotide binding] 1001583004894 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1001583004895 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1001583004896 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1001583004897 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1001583004898 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1001583004899 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1001583004900 RPB1 interaction site [polypeptide binding]; other site 1001583004901 RPB10 interaction site [polypeptide binding]; other site 1001583004902 RPB11 interaction site [polypeptide binding]; other site 1001583004903 RPB3 interaction site [polypeptide binding]; other site 1001583004904 RPB12 interaction site [polypeptide binding]; other site 1001583004905 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001583004906 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001583004907 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1001583004908 Clp amino terminal domain; Region: Clp_N; pfam02861 1001583004909 Clp amino terminal domain; Region: Clp_N; pfam02861 1001583004910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001583004911 Walker A motif; other site 1001583004912 ATP binding site [chemical binding]; other site 1001583004913 Walker B motif; other site 1001583004914 arginine finger; other site 1001583004915 UvrB/uvrC motif; Region: UVR; pfam02151 1001583004916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001583004917 Walker A motif; other site 1001583004918 ATP binding site [chemical binding]; other site 1001583004919 Walker B motif; other site 1001583004920 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1001583004921 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1001583004922 seryl-tRNA synthetase; Provisional; Region: PRK05431 1001583004923 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1001583004924 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1001583004925 dimer interface [polypeptide binding]; other site 1001583004926 active site 1001583004927 motif 1; other site 1001583004928 motif 2; other site 1001583004929 motif 3; other site 1001583004930 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1001583004931 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1001583004932 Substrate-binding site [chemical binding]; other site 1001583004933 Substrate specificity [chemical binding]; other site 1001583004934 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1001583004935 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1001583004936 lysine transporter; Provisional; Region: PRK10836 1001583004937 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1001583004938 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1001583004939 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1001583004940 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1001583004941 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1001583004942 active site 1001583004943 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1001583004944 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1001583004945 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1001583004946 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1001583004947 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1001583004948 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1001583004949 FeoA domain; Region: FeoA; pfam04023 1001583004950 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1001583004951 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1001583004952 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001583004953 Coenzyme A binding pocket [chemical binding]; other site 1001583004954 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1001583004955 DNA binding residues [nucleotide binding] 1001583004956 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1001583004957 putative dimer interface [polypeptide binding]; other site 1001583004958 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1001583004959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583004960 putative substrate translocation pore; other site 1001583004961 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1001583004962 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1001583004963 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1001583004964 Predicted membrane protein [Function unknown]; Region: COG4392 1001583004965 uracil transporter; Provisional; Region: PRK10720 1001583004966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583004967 H+ Antiporter protein; Region: 2A0121; TIGR00900 1001583004968 putative substrate translocation pore; other site 1001583004969 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1001583004970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001583004971 Coenzyme A binding pocket [chemical binding]; other site 1001583004972 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1001583004973 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1001583004974 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001583004975 Coenzyme A binding pocket [chemical binding]; other site 1001583004976 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1001583004977 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1001583004978 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1001583004979 active site 1001583004980 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1001583004981 lipoyl-biotinyl attachment site [posttranslational modification]; other site 1001583004982 putative transposase OrfB; Reviewed; Region: PHA02517 1001583004983 HTH-like domain; Region: HTH_21; pfam13276 1001583004984 Integrase core domain; Region: rve; pfam00665 1001583004985 Integrase core domain; Region: rve_2; pfam13333 1001583004986 Helix-turn-helix domain; Region: HTH_28; pfam13518 1001583004987 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1001583004988 Transposase; Region: HTH_Tnp_1; cl17663 1001583004989 maltose O-acetyltransferase; Provisional; Region: PRK10092 1001583004990 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1001583004991 active site 1001583004992 substrate binding site [chemical binding]; other site 1001583004993 trimer interface [polypeptide binding]; other site 1001583004994 CoA binding site [chemical binding]; other site 1001583004995 L-arabinose isomerase; Provisional; Region: PRK02929 1001583004996 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1001583004997 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1001583004998 substrate binding site [chemical binding]; other site 1001583004999 trimer interface [polypeptide binding]; other site 1001583005000 Mn binding site [ion binding]; other site 1001583005001 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1001583005002 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1001583005003 intersubunit interface [polypeptide binding]; other site 1001583005004 active site 1001583005005 Zn2+ binding site [ion binding]; other site 1001583005006 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 1001583005007 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1001583005008 putative N- and C-terminal domain interface [polypeptide binding]; other site 1001583005009 putative active site [active] 1001583005010 MgATP binding site [chemical binding]; other site 1001583005011 catalytic site [active] 1001583005012 metal binding site [ion binding]; metal-binding site 1001583005013 putative carbohydrate binding site [chemical binding]; other site 1001583005014 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1001583005015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583005016 putative substrate translocation pore; other site 1001583005017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583005018 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1001583005019 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1001583005020 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1001583005021 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001583005022 DNA-binding site [nucleotide binding]; DNA binding site 1001583005023 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1001583005024 putative dimerization interface [polypeptide binding]; other site 1001583005025 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1001583005026 putative ligand binding site [chemical binding]; other site 1001583005027 maltose O-acetyltransferase; Provisional; Region: PRK10092 1001583005028 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1001583005029 active site 1001583005030 substrate binding site [chemical binding]; other site 1001583005031 trimer interface [polypeptide binding]; other site 1001583005032 CoA binding site [chemical binding]; other site 1001583005033 Predicted transcriptional regulator [Transcription]; Region: COG4189 1001583005034 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001583005035 putative DNA binding site [nucleotide binding]; other site 1001583005036 dimerization interface [polypeptide binding]; other site 1001583005037 putative Zn2+ binding site [ion binding]; other site 1001583005038 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1001583005039 active site 1001583005040 galactoside permease; Reviewed; Region: lacY; PRK09528 1001583005041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583005042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583005043 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1001583005044 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1001583005045 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1001583005046 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1001583005047 ATP binding site [chemical binding]; other site 1001583005048 putative Mg++ binding site [ion binding]; other site 1001583005049 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001583005050 nucleotide binding region [chemical binding]; other site 1001583005051 ATP-binding site [chemical binding]; other site 1001583005052 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1001583005053 HRDC domain; Region: HRDC; pfam00570 1001583005054 Transcriptional regulator; Region: Rrf2; pfam02082 1001583005055 Rrf2 family protein; Region: rrf2_super; TIGR00738 1001583005056 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1001583005057 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1001583005058 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1001583005059 Peptidase family C69; Region: Peptidase_C69; pfam03577 1001583005060 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1001583005061 Peptidase family M1; Region: Peptidase_M1; pfam01433 1001583005062 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1001583005063 Zn binding site [ion binding]; other site 1001583005064 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 1001583005065 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1001583005066 Melibiase; Region: Melibiase; pfam02065 1001583005067 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 1001583005068 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1001583005069 active site 1001583005070 Holin family; Region: Phage_holin_4; pfam05105 1001583005071 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 1001583005072 Baseplate J-like protein; Region: Baseplate_J; cl01294 1001583005073 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1001583005074 LysM domain; Region: LysM; pfam01476 1001583005075 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1001583005076 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1001583005077 Peptidase family M23; Region: Peptidase_M23; pfam01551 1001583005078 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1001583005079 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1001583005080 catalytic residue [active] 1001583005081 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 1001583005082 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 1001583005083 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 1001583005084 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 1001583005085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 1001583005086 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 1001583005087 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3566 1001583005088 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 1001583005089 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001583005090 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1001583005091 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 1001583005092 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 1001583005093 Phage terminase large subunit; Region: Terminase_3; cl12054 1001583005094 Terminase-like family; Region: Terminase_6; pfam03237 1001583005095 Uncharacterized conserved protein [Function unknown]; Region: COG5484 1001583005096 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1001583005097 Beta protein; Region: Beta_protein; pfam14350 1001583005098 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1001583005099 YopX protein; Region: YopX; pfam09643 1001583005100 AntA/AntB antirepressor; Region: AntA; pfam08346 1001583005101 ORF6C domain; Region: ORF6C; pfam10552 1001583005102 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 1001583005103 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 1001583005104 RecT family; Region: RecT; pfam03837 1001583005105 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1001583005106 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001583005107 non-specific DNA binding site [nucleotide binding]; other site 1001583005108 salt bridge; other site 1001583005109 sequence-specific DNA binding site [nucleotide binding]; other site 1001583005110 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1001583005111 Double zinc ribbon; Region: DZR; pfam12773 1001583005112 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1001583005113 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1001583005114 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1001583005115 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1001583005116 active site 1001583005117 catalytic residues [active] 1001583005118 DNA binding site [nucleotide binding] 1001583005119 Int/Topo IB signature motif; other site 1001583005120 GMP synthase; Reviewed; Region: guaA; PRK00074 1001583005121 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1001583005122 AMP/PPi binding site [chemical binding]; other site 1001583005123 candidate oxyanion hole; other site 1001583005124 catalytic triad [active] 1001583005125 potential glutamine specificity residues [chemical binding]; other site 1001583005126 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1001583005127 ATP Binding subdomain [chemical binding]; other site 1001583005128 Dimerization subdomain; other site 1001583005129 pantothenate kinase; Provisional; Region: PRK05439 1001583005130 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1001583005131 ATP-binding site [chemical binding]; other site 1001583005132 CoA-binding site [chemical binding]; other site 1001583005133 Mg2+-binding site [ion binding]; other site 1001583005134 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1001583005135 Part of AAA domain; Region: AAA_19; pfam13245 1001583005136 Family description; Region: UvrD_C_2; pfam13538 1001583005137 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1001583005138 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1001583005139 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1001583005140 TrkA-C domain; Region: TrkA_C; pfam02080 1001583005141 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1001583005142 catalytic core [active] 1001583005143 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1001583005144 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1001583005145 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1001583005146 Walker A/P-loop; other site 1001583005147 ATP binding site [chemical binding]; other site 1001583005148 Q-loop/lid; other site 1001583005149 ABC transporter signature motif; other site 1001583005150 Walker B; other site 1001583005151 D-loop; other site 1001583005152 H-loop/switch region; other site 1001583005153 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1001583005154 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1001583005155 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1001583005156 Walker A/P-loop; other site 1001583005157 ATP binding site [chemical binding]; other site 1001583005158 Q-loop/lid; other site 1001583005159 ABC transporter signature motif; other site 1001583005160 Walker B; other site 1001583005161 D-loop; other site 1001583005162 H-loop/switch region; other site 1001583005163 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1001583005164 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1001583005165 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1001583005166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001583005167 dimer interface [polypeptide binding]; other site 1001583005168 conserved gate region; other site 1001583005169 putative PBP binding loops; other site 1001583005170 ABC-ATPase subunit interface; other site 1001583005171 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1001583005172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001583005173 dimer interface [polypeptide binding]; other site 1001583005174 conserved gate region; other site 1001583005175 putative PBP binding loops; other site 1001583005176 ABC-ATPase subunit interface; other site 1001583005177 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1001583005178 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1001583005179 peptide binding site [polypeptide binding]; other site 1001583005180 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1001583005181 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1001583005182 peptide binding site [polypeptide binding]; other site 1001583005183 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1001583005184 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1001583005185 HflX GTPase family; Region: HflX; cd01878 1001583005186 G1 box; other site 1001583005187 GTP/Mg2+ binding site [chemical binding]; other site 1001583005188 Switch I region; other site 1001583005189 G2 box; other site 1001583005190 G3 box; other site 1001583005191 Switch II region; other site 1001583005192 G4 box; other site 1001583005193 G5 box; other site 1001583005194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001583005195 dimer interface [polypeptide binding]; other site 1001583005196 conserved gate region; other site 1001583005197 putative PBP binding loops; other site 1001583005198 ABC-ATPase subunit interface; other site 1001583005199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001583005200 dimer interface [polypeptide binding]; other site 1001583005201 conserved gate region; other site 1001583005202 putative PBP binding loops; other site 1001583005203 ABC-ATPase subunit interface; other site 1001583005204 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1001583005205 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1001583005206 substrate binding pocket [chemical binding]; other site 1001583005207 membrane-bound complex binding site; other site 1001583005208 hinge residues; other site 1001583005209 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1001583005210 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1001583005211 Walker A/P-loop; other site 1001583005212 ATP binding site [chemical binding]; other site 1001583005213 Q-loop/lid; other site 1001583005214 ABC transporter signature motif; other site 1001583005215 Walker B; other site 1001583005216 D-loop; other site 1001583005217 H-loop/switch region; other site 1001583005218 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1001583005219 metal binding site 2 [ion binding]; metal-binding site 1001583005220 putative DNA binding helix; other site 1001583005221 metal binding site 1 [ion binding]; metal-binding site 1001583005222 dimer interface [polypeptide binding]; other site 1001583005223 structural Zn2+ binding site [ion binding]; other site 1001583005224 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1001583005225 catalytic site [active] 1001583005226 G-X2-G-X-G-K; other site 1001583005227 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 1001583005228 active site 1001583005229 Ap4A binding cleft/pocket [chemical binding]; other site 1001583005230 P4 phosphate binding site; other site 1001583005231 nudix motif; other site 1001583005232 putative P2/P3 phosphate binding site [ion binding]; other site 1001583005233 amino acid transporter; Region: 2A0306; TIGR00909 1001583005234 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1001583005235 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 1001583005236 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 1001583005237 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1001583005238 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1001583005239 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1001583005240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1001583005241 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1001583005242 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001583005243 Walker A/P-loop; other site 1001583005244 ATP binding site [chemical binding]; other site 1001583005245 Q-loop/lid; other site 1001583005246 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1001583005247 ABC transporter signature motif; other site 1001583005248 Walker B; other site 1001583005249 D-loop; other site 1001583005250 ABC transporter; Region: ABC_tran_2; pfam12848 1001583005251 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1001583005252 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1001583005253 dimer interface [polypeptide binding]; other site 1001583005254 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1001583005255 metal binding site [ion binding]; metal-binding site 1001583005256 CAAX protease self-immunity; Region: Abi; pfam02517 1001583005257 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1001583005258 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001583005259 Walker A/P-loop; other site 1001583005260 ATP binding site [chemical binding]; other site 1001583005261 Q-loop/lid; other site 1001583005262 ABC transporter signature motif; other site 1001583005263 Walker B; other site 1001583005264 D-loop; other site 1001583005265 H-loop/switch region; other site 1001583005266 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1001583005267 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1001583005268 TM-ABC transporter signature motif; other site 1001583005269 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1001583005270 zinc binding site [ion binding]; other site 1001583005271 putative ligand binding site [chemical binding]; other site 1001583005272 EDD domain protein, DegV family; Region: DegV; TIGR00762 1001583005273 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1001583005274 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1001583005275 zinc binding site [ion binding]; other site 1001583005276 putative ligand binding site [chemical binding]; other site 1001583005277 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1001583005278 TM-ABC transporter signature motif; other site 1001583005279 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1001583005280 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001583005281 Walker A/P-loop; other site 1001583005282 ATP binding site [chemical binding]; other site 1001583005283 Q-loop/lid; other site 1001583005284 ABC transporter signature motif; other site 1001583005285 Walker B; other site 1001583005286 D-loop; other site 1001583005287 H-loop/switch region; other site 1001583005288 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1001583005289 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1001583005290 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1001583005291 SH3-like domain; Region: SH3_8; pfam13457 1001583005292 Beta-lactamase; Region: Beta-lactamase; pfam00144 1001583005293 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1001583005294 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1001583005295 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1001583005296 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1001583005297 putative active site [active] 1001583005298 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1001583005299 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1001583005300 active site 1001583005301 acetoin reductases; Region: 23BDH; TIGR02415 1001583005302 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001583005303 NAD(P) binding site [chemical binding]; other site 1001583005304 active site 1001583005305 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1001583005306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583005307 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001583005308 putative substrate translocation pore; other site 1001583005309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583005310 Predicted transcriptional regulators [Transcription]; Region: COG1695 1001583005311 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1001583005312 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1001583005313 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1001583005314 DNA binding residues [nucleotide binding] 1001583005315 putative dimer interface [polypeptide binding]; other site 1001583005316 NlpC/P60 family; Region: NLPC_P60; pfam00877 1001583005317 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1001583005318 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1001583005319 catalytic core [active] 1001583005320 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1001583005321 Sulfatase; Region: Sulfatase; pfam00884 1001583005322 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1001583005323 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1001583005324 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1001583005325 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1001583005326 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1001583005327 active site 1001583005328 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1001583005329 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001583005330 active site 1001583005331 motif I; other site 1001583005332 motif II; other site 1001583005333 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1001583005334 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1001583005335 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1001583005336 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1001583005337 DNA binding residues [nucleotide binding] 1001583005338 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 1001583005339 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 1001583005340 GIY-YIG motif/motif A; other site 1001583005341 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 1001583005342 Chloramphenicol acetyltransferase; Region: CAT; smart01059 1001583005343 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1001583005344 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1001583005345 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1001583005346 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1001583005347 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1001583005348 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1001583005349 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1001583005350 Walker A/P-loop; other site 1001583005351 ATP binding site [chemical binding]; other site 1001583005352 Q-loop/lid; other site 1001583005353 ABC transporter signature motif; other site 1001583005354 Walker B; other site 1001583005355 D-loop; other site 1001583005356 H-loop/switch region; other site 1001583005357 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1001583005358 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 1001583005359 Walker A/P-loop; other site 1001583005360 ATP binding site [chemical binding]; other site 1001583005361 Q-loop/lid; other site 1001583005362 ABC transporter signature motif; other site 1001583005363 Walker B; other site 1001583005364 D-loop; other site 1001583005365 H-loop/switch region; other site 1001583005366 Cobalt transport protein; Region: CbiQ; cl00463 1001583005367 Putative transcription activator [Transcription]; Region: TenA; COG0819 1001583005368 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1001583005369 active site 1001583005370 homotetramer interface [polypeptide binding]; other site 1001583005371 homodimer interface [polypeptide binding]; other site 1001583005372 xanthine permease; Region: pbuX; TIGR03173 1001583005373 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1001583005374 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1001583005375 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001583005376 Walker A/P-loop; other site 1001583005377 ATP binding site [chemical binding]; other site 1001583005378 Q-loop/lid; other site 1001583005379 ABC transporter signature motif; other site 1001583005380 Walker B; other site 1001583005381 D-loop; other site 1001583005382 H-loop/switch region; other site 1001583005383 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1001583005384 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1001583005385 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1001583005386 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1001583005387 EDD domain protein, DegV family; Region: DegV; TIGR00762 1001583005388 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1001583005389 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1001583005390 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1001583005391 active site 1001583005392 catalytic tetrad [active] 1001583005393 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 1001583005394 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1001583005395 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 1001583005396 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1001583005397 catalytic residue [active] 1001583005398 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1001583005399 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1001583005400 ligand binding site [chemical binding]; other site 1001583005401 flexible hinge region; other site 1001583005402 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1001583005403 putative switch regulator; other site 1001583005404 non-specific DNA interactions [nucleotide binding]; other site 1001583005405 DNA binding site [nucleotide binding] 1001583005406 sequence specific DNA binding site [nucleotide binding]; other site 1001583005407 putative cAMP binding site [chemical binding]; other site 1001583005408 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 1001583005409 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 1001583005410 AIR carboxylase; Region: AIRC; smart01001 1001583005411 Protein of unknown function DUF111; Region: DUF111; pfam01969 1001583005412 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 1001583005413 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 1001583005414 Ligand Binding Site [chemical binding]; other site 1001583005415 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1001583005416 amphipathic channel; other site 1001583005417 Asn-Pro-Ala signature motifs; other site 1001583005418 High-affinity nickel-transport protein; Region: NicO; cl00964 1001583005419 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1001583005420 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583005421 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583005422 Integrase core domain; Region: rve; pfam00665 1001583005423 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1001583005424 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1001583005425 Walker A/P-loop; other site 1001583005426 ATP binding site [chemical binding]; other site 1001583005427 Q-loop/lid; other site 1001583005428 ABC transporter signature motif; other site 1001583005429 Walker B; other site 1001583005430 D-loop; other site 1001583005431 H-loop/switch region; other site 1001583005432 TOBE domain; Region: TOBE_2; pfam08402 1001583005433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001583005434 dimer interface [polypeptide binding]; other site 1001583005435 conserved gate region; other site 1001583005436 putative PBP binding loops; other site 1001583005437 ABC-ATPase subunit interface; other site 1001583005438 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1001583005439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001583005440 dimer interface [polypeptide binding]; other site 1001583005441 conserved gate region; other site 1001583005442 putative PBP binding loops; other site 1001583005443 ABC-ATPase subunit interface; other site 1001583005444 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1001583005445 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1001583005446 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 1001583005447 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1001583005448 Walker A/P-loop; other site 1001583005449 ATP binding site [chemical binding]; other site 1001583005450 Q-loop/lid; other site 1001583005451 ABC transporter signature motif; other site 1001583005452 Walker B; other site 1001583005453 D-loop; other site 1001583005454 H-loop/switch region; other site 1001583005455 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1001583005456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001583005457 dimer interface [polypeptide binding]; other site 1001583005458 conserved gate region; other site 1001583005459 putative PBP binding loops; other site 1001583005460 ABC-ATPase subunit interface; other site 1001583005461 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1001583005462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001583005463 dimer interface [polypeptide binding]; other site 1001583005464 conserved gate region; other site 1001583005465 putative PBP binding loops; other site 1001583005466 ABC-ATPase subunit interface; other site 1001583005467 PBP superfamily domain; Region: PBP_like_2; cl17296 1001583005468 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1001583005469 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 1001583005470 regulatory protein interface [polypeptide binding]; other site 1001583005471 regulatory phosphorylation site [posttranslational modification]; other site 1001583005472 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1001583005473 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1001583005474 DEAD_2; Region: DEAD_2; pfam06733 1001583005475 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1001583005476 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1001583005477 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1001583005478 Walker A/P-loop; other site 1001583005479 ATP binding site [chemical binding]; other site 1001583005480 Q-loop/lid; other site 1001583005481 ABC transporter signature motif; other site 1001583005482 Walker B; other site 1001583005483 D-loop; other site 1001583005484 H-loop/switch region; other site 1001583005485 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1001583005486 active site 1001583005487 zinc binding site [ion binding]; other site 1001583005488 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1001583005489 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1001583005490 active site 1001583005491 ATP binding site [chemical binding]; other site 1001583005492 substrate binding site [chemical binding]; other site 1001583005493 activation loop (A-loop); other site 1001583005494 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1001583005495 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1001583005496 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1001583005497 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1001583005498 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1001583005499 metal binding site 2 [ion binding]; metal-binding site 1001583005500 putative DNA binding helix; other site 1001583005501 metal binding site 1 [ion binding]; metal-binding site 1001583005502 dimer interface [polypeptide binding]; other site 1001583005503 structural Zn2+ binding site [ion binding]; other site 1001583005504 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1001583005505 amidase catalytic site [active] 1001583005506 Zn binding residues [ion binding]; other site 1001583005507 substrate binding site [chemical binding]; other site 1001583005508 YibE/F-like protein; Region: YibE_F; pfam07907 1001583005509 YibE/F-like protein; Region: YibE_F; pfam07907 1001583005510 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1001583005511 Ligand Binding Site [chemical binding]; other site 1001583005512 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1001583005513 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1001583005514 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1001583005515 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1001583005516 active site 1001583005517 Zn binding site [ion binding]; other site 1001583005518 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583005519 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583005520 Integrase core domain; Region: rve; pfam00665 1001583005521 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1001583005522 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1001583005523 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 1001583005524 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1001583005525 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 1001583005526 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1001583005527 DNA binding site [nucleotide binding] 1001583005528 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1001583005529 putative dimerization interface [polypeptide binding]; other site 1001583005530 putative ligand binding site [chemical binding]; other site 1001583005531 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1001583005532 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1001583005533 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1001583005534 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1001583005535 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1001583005536 NAD binding site [chemical binding]; other site 1001583005537 homodimer interface [polypeptide binding]; other site 1001583005538 active site 1001583005539 substrate binding site [chemical binding]; other site 1001583005540 galactokinase; Provisional; Region: PRK05322 1001583005541 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1001583005542 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1001583005543 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1001583005544 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1001583005545 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1001583005546 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1001583005547 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1001583005548 active site 1001583005549 substrate binding site [chemical binding]; other site 1001583005550 metal binding site [ion binding]; metal-binding site 1001583005551 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1001583005552 active site 1001583005553 catalytic residues [active] 1001583005554 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1001583005555 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1001583005556 active site 1001583005557 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1001583005558 Ligand binding site [chemical binding]; other site 1001583005559 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1001583005560 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1001583005561 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1001583005562 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1001583005563 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1001583005564 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1001583005565 putative NAD(P) binding site [chemical binding]; other site 1001583005566 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001583005567 putative DNA binding site [nucleotide binding]; other site 1001583005568 putative Zn2+ binding site [ion binding]; other site 1001583005569 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1001583005570 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1001583005571 potential catalytic triad [active] 1001583005572 conserved cys residue [active] 1001583005573 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1001583005574 active site 1001583005575 metal-binding site [ion binding] 1001583005576 nucleotide-binding site [chemical binding]; other site 1001583005577 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1001583005578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583005579 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001583005580 putative substrate translocation pore; other site 1001583005581 methionine aminopeptidase; Provisional; Region: PRK08671 1001583005582 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1001583005583 active site 1001583005584 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1001583005585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001583005586 S-adenosylmethionine binding site [chemical binding]; other site 1001583005587 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1001583005588 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001583005589 non-specific DNA binding site [nucleotide binding]; other site 1001583005590 salt bridge; other site 1001583005591 sequence-specific DNA binding site [nucleotide binding]; other site 1001583005592 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1001583005593 active site 1001583005594 DNA binding site [nucleotide binding] 1001583005595 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1001583005596 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1001583005597 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001583005598 motif II; other site 1001583005599 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1001583005600 Ligand Binding Site [chemical binding]; other site 1001583005601 BCCT family transporter; Region: BCCT; pfam02028 1001583005602 maltose O-acetyltransferase; Provisional; Region: PRK10092 1001583005603 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1001583005604 active site 1001583005605 substrate binding site [chemical binding]; other site 1001583005606 trimer interface [polypeptide binding]; other site 1001583005607 CoA binding site [chemical binding]; other site 1001583005608 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583005609 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583005610 Homeodomain-like domain; Region: HTH_32; pfam13565 1001583005611 Integrase core domain; Region: rve; pfam00665 1001583005612 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1001583005613 dimer interface [polypeptide binding]; other site 1001583005614 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 1001583005615 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1001583005616 RNA/DNA hybrid binding site [nucleotide binding]; other site 1001583005617 active site 1001583005618 cytosine deaminase; Provisional; Region: PRK09230 1001583005619 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1001583005620 active site 1001583005621 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1001583005622 dimer interface [polypeptide binding]; other site 1001583005623 substrate binding site [chemical binding]; other site 1001583005624 ATP binding site [chemical binding]; other site 1001583005625 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1001583005626 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 1001583005627 Predicted esterase [General function prediction only]; Region: COG0400 1001583005628 putative hydrolase; Provisional; Region: PRK11460 1001583005629 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1001583005630 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1001583005631 minor groove reading motif; other site 1001583005632 helix-hairpin-helix signature motif; other site 1001583005633 substrate binding pocket [chemical binding]; other site 1001583005634 active site 1001583005635 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1001583005636 DNA binding and oxoG recognition site [nucleotide binding] 1001583005637 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1001583005638 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1001583005639 peptide binding site [polypeptide binding]; other site 1001583005640 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1001583005641 MucBP domain; Region: MucBP; pfam06458 1001583005642 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1001583005643 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1001583005644 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1001583005645 lipoyl attachment site [posttranslational modification]; other site 1001583005646 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1001583005647 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1001583005648 active site 1001583005649 catalytic tetrad [active] 1001583005650 EamA-like transporter family; Region: EamA; pfam00892 1001583005651 EamA-like transporter family; Region: EamA; pfam00892 1001583005652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001583005653 dimer interface [polypeptide binding]; other site 1001583005654 conserved gate region; other site 1001583005655 ABC-ATPase subunit interface; other site 1001583005656 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1001583005657 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1001583005658 Walker A/P-loop; other site 1001583005659 ATP binding site [chemical binding]; other site 1001583005660 Q-loop/lid; other site 1001583005661 ABC transporter signature motif; other site 1001583005662 Walker B; other site 1001583005663 D-loop; other site 1001583005664 H-loop/switch region; other site 1001583005665 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1001583005666 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1001583005667 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1001583005668 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1001583005669 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1001583005670 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1001583005671 peptide binding site [polypeptide binding]; other site 1001583005672 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1001583005673 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1001583005674 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1001583005675 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1001583005676 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1001583005677 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1001583005678 active site 1001583005679 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1001583005680 AAA domain; Region: AAA_23; pfam13476 1001583005681 Walker A/P-loop; other site 1001583005682 ATP binding site [chemical binding]; other site 1001583005683 Q-loop/lid; other site 1001583005684 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1001583005685 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001583005686 ABC transporter signature motif; other site 1001583005687 Walker B; other site 1001583005688 D-loop; other site 1001583005689 H-loop/switch region; other site 1001583005690 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1001583005691 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1001583005692 active site 1001583005693 metal binding site [ion binding]; metal-binding site 1001583005694 DNA binding site [nucleotide binding] 1001583005695 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1001583005696 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1001583005697 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1001583005698 active site 1001583005699 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 1001583005700 active site 1001583005701 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1001583005702 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1001583005703 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1001583005704 Cupin domain; Region: Cupin_2; cl17218 1001583005705 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 1001583005706 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1001583005707 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1001583005708 DNA binding residues [nucleotide binding] 1001583005709 putative dimer interface [polypeptide binding]; other site 1001583005710 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001583005711 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001583005712 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1001583005713 MarR family; Region: MarR_2; pfam12802 1001583005714 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1001583005715 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1001583005716 active site 1001583005717 catalytic tetrad [active] 1001583005718 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1001583005719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583005720 putative substrate translocation pore; other site 1001583005721 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1001583005722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583005723 putative substrate translocation pore; other site 1001583005724 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1001583005725 phosphate binding site [ion binding]; other site 1001583005726 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1001583005727 Hexamer/Pentamer interface [polypeptide binding]; other site 1001583005728 central pore; other site 1001583005729 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1001583005730 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1001583005731 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1001583005732 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 1001583005733 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1001583005734 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1001583005735 Walker A/P-loop; other site 1001583005736 ATP binding site [chemical binding]; other site 1001583005737 Q-loop/lid; other site 1001583005738 ABC transporter signature motif; other site 1001583005739 Walker B; other site 1001583005740 D-loop; other site 1001583005741 H-loop/switch region; other site 1001583005742 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1001583005743 Walker A/P-loop; other site 1001583005744 ATP binding site [chemical binding]; other site 1001583005745 Q-loop/lid; other site 1001583005746 ABC transporter signature motif; other site 1001583005747 Walker B; other site 1001583005748 D-loop; other site 1001583005749 H-loop/switch region; other site 1001583005750 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1001583005751 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1001583005752 Flavoprotein; Region: Flavoprotein; pfam02441 1001583005753 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 1001583005754 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1001583005755 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001583005756 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1001583005757 dimerization interface [polypeptide binding]; other site 1001583005758 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1001583005759 active site 1001583005760 catalytic residues [active] 1001583005761 metal binding site [ion binding]; metal-binding site 1001583005762 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1001583005763 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1001583005764 active site 1001583005765 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1001583005766 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1001583005767 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1001583005768 amphipathic channel; other site 1001583005769 Asn-Pro-Ala signature motifs; other site 1001583005770 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1001583005771 putative substrate binding pocket [chemical binding]; other site 1001583005772 AC domain interface; other site 1001583005773 catalytic triad [active] 1001583005774 AB domain interface; other site 1001583005775 interchain disulfide; other site 1001583005776 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1001583005777 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1001583005778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001583005779 Walker A/P-loop; other site 1001583005780 ATP binding site [chemical binding]; other site 1001583005781 Q-loop/lid; other site 1001583005782 ABC transporter signature motif; other site 1001583005783 Walker B; other site 1001583005784 D-loop; other site 1001583005785 H-loop/switch region; other site 1001583005786 MarR family; Region: MarR_2; cl17246 1001583005787 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001583005788 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1001583005789 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1001583005790 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1001583005791 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1001583005792 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001583005793 Walker A/P-loop; other site 1001583005794 ATP binding site [chemical binding]; other site 1001583005795 Q-loop/lid; other site 1001583005796 ABC transporter signature motif; other site 1001583005797 Walker B; other site 1001583005798 D-loop; other site 1001583005799 H-loop/switch region; other site 1001583005800 Predicted transcriptional regulators [Transcription]; Region: COG1725 1001583005801 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001583005802 DNA-binding site [nucleotide binding]; DNA binding site 1001583005803 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1001583005804 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1001583005805 catalytic residues [active] 1001583005806 dimer interface [polypeptide binding]; other site 1001583005807 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1001583005808 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001583005809 active site 1001583005810 motif I; other site 1001583005811 motif II; other site 1001583005812 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001583005813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583005814 putative substrate translocation pore; other site 1001583005815 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1001583005816 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001583005817 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1001583005818 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1001583005819 active site 1001583005820 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1001583005821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001583005822 NAD(P) binding site [chemical binding]; other site 1001583005823 active site 1001583005824 Predicted transcriptional regulators [Transcription]; Region: COG1733 1001583005825 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1001583005826 Asp23 family; Region: Asp23; pfam03780 1001583005827 Asp23 family; Region: Asp23; pfam03780 1001583005828 Predicted membrane protein [Function unknown]; Region: COG2261 1001583005829 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1001583005830 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1001583005831 putative dimer interface [polypeptide binding]; other site 1001583005832 putative anticodon binding site; other site 1001583005833 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1001583005834 homodimer interface [polypeptide binding]; other site 1001583005835 motif 1; other site 1001583005836 motif 2; other site 1001583005837 active site 1001583005838 motif 3; other site 1001583005839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583005840 putative substrate translocation pore; other site 1001583005841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583005842 Predicted transcriptional regulators [Transcription]; Region: COG1695 1001583005843 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1001583005844 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1001583005845 B3/4 domain; Region: B3_4; pfam03483 1001583005846 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1001583005847 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1001583005848 ligand binding site [chemical binding]; other site 1001583005849 flexible hinge region; other site 1001583005850 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1001583005851 carbamate kinase; Reviewed; Region: PRK12686 1001583005852 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1001583005853 putative substrate binding site [chemical binding]; other site 1001583005854 nucleotide binding site [chemical binding]; other site 1001583005855 nucleotide binding site [chemical binding]; other site 1001583005856 homodimer interface [polypeptide binding]; other site 1001583005857 transaminase; Validated; Region: PRK07324 1001583005858 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1001583005859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001583005860 homodimer interface [polypeptide binding]; other site 1001583005861 catalytic residue [active] 1001583005862 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1001583005863 ornithine carbamoyltransferase; Validated; Region: PRK02102 1001583005864 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1001583005865 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1001583005866 arginine deiminase; Provisional; Region: PRK01388 1001583005867 Predicted membrane protein [Function unknown]; Region: COG1288 1001583005868 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1001583005869 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1001583005870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001583005871 ATP binding site [chemical binding]; other site 1001583005872 Mg2+ binding site [ion binding]; other site 1001583005873 G-X-G motif; other site 1001583005874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001583005875 Response regulator receiver domain; Region: Response_reg; pfam00072 1001583005876 active site 1001583005877 phosphorylation site [posttranslational modification] 1001583005878 intermolecular recognition site; other site 1001583005879 dimerization interface [polypeptide binding]; other site 1001583005880 YcbB domain; Region: YcbB; pfam08664 1001583005881 Predicted membrane protein [Function unknown]; Region: COG1288 1001583005882 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1001583005883 hypothetical protein; Provisional; Region: PRK07205 1001583005884 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1001583005885 active site 1001583005886 metal binding site [ion binding]; metal-binding site 1001583005887 Predicted membrane protein [Function unknown]; Region: COG3371 1001583005888 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1001583005889 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1001583005890 conserved cys residue [active] 1001583005891 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1001583005892 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1001583005893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583005894 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001583005895 putative substrate translocation pore; other site 1001583005896 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1001583005897 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001583005898 Coenzyme A binding pocket [chemical binding]; other site 1001583005899 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1001583005900 catalytic core [active] 1001583005901 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1001583005902 Collagen binding domain; Region: Collagen_bind; pfam05737 1001583005903 Cna protein B-type domain; Region: Cna_B; pfam05738 1001583005904 Cna protein B-type domain; Region: Cna_B; pfam05738 1001583005905 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1001583005906 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1001583005907 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1001583005908 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1001583005909 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1001583005910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001583005911 S-adenosylmethionine binding site [chemical binding]; other site 1001583005912 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1001583005913 AzlC protein; Region: AzlC; cl00570 1001583005914 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1001583005915 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001583005916 Coenzyme A binding pocket [chemical binding]; other site 1001583005917 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1001583005918 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001583005919 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1001583005920 Predicted membrane protein [Function unknown]; Region: COG1511 1001583005921 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1001583005922 Predicted membrane protein [Function unknown]; Region: COG1511 1001583005923 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1001583005924 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1001583005925 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1001583005926 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1001583005927 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1001583005928 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1001583005929 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1001583005930 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1001583005931 dimer interface [polypeptide binding]; other site 1001583005932 phosphorylation site [posttranslational modification] 1001583005933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001583005934 ATP binding site [chemical binding]; other site 1001583005935 Mg2+ binding site [ion binding]; other site 1001583005936 G-X-G motif; other site 1001583005937 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1001583005938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001583005939 active site 1001583005940 phosphorylation site [posttranslational modification] 1001583005941 intermolecular recognition site; other site 1001583005942 dimerization interface [polypeptide binding]; other site 1001583005943 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1001583005944 DNA binding site [nucleotide binding] 1001583005945 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 1001583005946 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1001583005947 active site 1001583005948 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 1001583005949 GTP-binding protein YchF; Reviewed; Region: PRK09601 1001583005950 YchF GTPase; Region: YchF; cd01900 1001583005951 G1 box; other site 1001583005952 GTP/Mg2+ binding site [chemical binding]; other site 1001583005953 Switch I region; other site 1001583005954 G2 box; other site 1001583005955 Switch II region; other site 1001583005956 G3 box; other site 1001583005957 G4 box; other site 1001583005958 G5 box; other site 1001583005959 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1001583005960 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1001583005961 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1001583005962 ParB-like nuclease domain; Region: ParBc; pfam02195 1001583005963 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1001583005964 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1001583005965 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1001583005966 Magnesium ion binding site [ion binding]; other site 1001583005967 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1001583005968 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1001583005969 ParB-like nuclease domain; Region: ParBc; pfam02195 1001583005970 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1001583005971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001583005972 S-adenosylmethionine binding site [chemical binding]; other site 1001583005973 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1001583005974 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1001583005975 active site 1001583005976 metal binding site [ion binding]; metal-binding site 1001583005977 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1001583005978 active site 1001583005979 tetramer interface [polypeptide binding]; other site 1001583005980 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1001583005981 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1001583005982 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1001583005983 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1001583005984 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 1001583005985 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 1001583005986 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 1001583005987 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1001583005988 putative NAD(P) binding site [chemical binding]; other site 1001583005989 MarR family; Region: MarR_2; pfam12802 1001583005990 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583005991 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583005992 Homeodomain-like domain; Region: HTH_32; pfam13565 1001583005993 Integrase core domain; Region: rve; pfam00665 1001583005994 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1001583005995 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1001583005996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001583005997 homodimer interface [polypeptide binding]; other site 1001583005998 catalytic residue [active] 1001583005999 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1001583006000 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001583006001 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1001583006002 dimerization interface [polypeptide binding]; other site 1001583006003 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 1001583006004 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1001583006005 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1001583006006 Y-family of DNA polymerases; Region: PolY; cl12025 1001583006007 DNA binding site [nucleotide binding] 1001583006008 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1001583006009 Y-family of DNA polymerases; Region: PolY; cl12025 1001583006010 active site 1001583006011 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1001583006012 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1001583006013 Walker A/P-loop; other site 1001583006014 ATP binding site [chemical binding]; other site 1001583006015 Q-loop/lid; other site 1001583006016 ABC transporter signature motif; other site 1001583006017 Walker B; other site 1001583006018 D-loop; other site 1001583006019 H-loop/switch region; other site 1001583006020 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1001583006021 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1001583006022 FtsX-like permease family; Region: FtsX; pfam02687 1001583006023 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1001583006024 thiamine phosphate binding site [chemical binding]; other site 1001583006025 active site 1001583006026 pyrophosphate binding site [ion binding]; other site 1001583006027 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1001583006028 substrate binding site [chemical binding]; other site 1001583006029 dimer interface [polypeptide binding]; other site 1001583006030 ATP binding site [chemical binding]; other site 1001583006031 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1001583006032 substrate binding site [chemical binding]; other site 1001583006033 multimerization interface [polypeptide binding]; other site 1001583006034 ATP binding site [chemical binding]; other site 1001583006035 short chain dehydrogenase; Validated; Region: PRK06182 1001583006036 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1001583006037 NADP binding site [chemical binding]; other site 1001583006038 active site 1001583006039 steroid binding site; other site 1001583006040 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1001583006041 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 1001583006042 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1001583006043 Walker A/P-loop; other site 1001583006044 ATP binding site [chemical binding]; other site 1001583006045 Q-loop/lid; other site 1001583006046 ABC transporter signature motif; other site 1001583006047 Walker B; other site 1001583006048 D-loop; other site 1001583006049 H-loop/switch region; other site 1001583006050 TRAM domain; Region: TRAM; cl01282 1001583006051 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1001583006052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001583006053 S-adenosylmethionine binding site [chemical binding]; other site 1001583006054 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1001583006055 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1001583006056 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1001583006057 DNA binding residues [nucleotide binding] 1001583006058 putative dimer interface [polypeptide binding]; other site 1001583006059 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1001583006060 hydrophobic ligand binding site; other site 1001583006061 Domain of unknown function (DUF368); Region: DUF368; cl00893 1001583006062 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1001583006063 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1001583006064 DNA binding residues [nucleotide binding] 1001583006065 dimer interface [polypeptide binding]; other site 1001583006066 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1001583006067 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1001583006068 nucleotide binding site [chemical binding]; other site 1001583006069 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1001583006070 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1001583006071 active site 1001583006072 catalytic tetrad [active] 1001583006073 recombination factor protein RarA; Reviewed; Region: PRK13342 1001583006074 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001583006075 Walker A motif; other site 1001583006076 ATP binding site [chemical binding]; other site 1001583006077 Walker B motif; other site 1001583006078 arginine finger; other site 1001583006079 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1001583006080 phosphodiesterase; Provisional; Region: PRK12704 1001583006081 KH domain; Region: KH_1; pfam00013 1001583006082 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1001583006083 Zn2+ binding site [ion binding]; other site 1001583006084 Mg2+ binding site [ion binding]; other site 1001583006085 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1001583006086 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1001583006087 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1001583006088 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1001583006089 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1001583006090 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 1001583006091 active site 1001583006092 Zn binding site [ion binding]; other site 1001583006093 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001583006094 non-specific DNA binding site [nucleotide binding]; other site 1001583006095 salt bridge; other site 1001583006096 sequence-specific DNA binding site [nucleotide binding]; other site 1001583006097 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1001583006098 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1001583006099 putative active site [active] 1001583006100 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1001583006101 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1001583006102 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1001583006103 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1001583006104 amino acid transporter; Region: 2A0306; TIGR00909 1001583006105 L-type amino acid transporter; Region: 2A0308; TIGR00911 1001583006106 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1001583006107 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 1001583006108 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1001583006109 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1001583006110 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 1001583006111 Helix-turn-helix domain; Region: HTH_17; pfam12728 1001583006112 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 1001583006113 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1001583006114 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1001583006115 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001583006116 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1001583006117 non-specific DNA binding site [nucleotide binding]; other site 1001583006118 salt bridge; other site 1001583006119 sequence-specific DNA binding site [nucleotide binding]; other site 1001583006120 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1001583006121 Int/Topo IB signature motif; other site 1001583006122 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1001583006123 amidase catalytic site [active] 1001583006124 Zn binding residues [ion binding]; other site 1001583006125 substrate binding site [chemical binding]; other site 1001583006126 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1001583006127 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 1001583006128 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1001583006129 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1001583006130 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 1001583006131 tape measure domain; Region: tape_meas_nterm; TIGR02675 1001583006132 Phage XkdN-like protein; Region: XkdN; pfam08890 1001583006133 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1001583006134 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1001583006135 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 1001583006136 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 1001583006137 HeH/LEM domain; Region: HeH; pfam12949 1001583006138 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 1001583006139 YjcQ protein; Region: YjcQ; pfam09639 1001583006140 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1001583006141 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1001583006142 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 1001583006143 Phage terminase large subunit; Region: Terminase_3; cl12054 1001583006144 Terminase-like family; Region: Terminase_6; pfam03237 1001583006145 Terminase small subunit; Region: Terminase_2; pfam03592 1001583006146 YopX protein; Region: YopX; pfam09643 1001583006147 Uncharacterized conserved protein [Function unknown]; Region: COG4983 1001583006148 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1001583006149 nucleotide binding site [chemical binding]; other site 1001583006150 D5 N terminal like; Region: D5_N; pfam08706 1001583006151 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1001583006152 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 1001583006153 Protein of unknown function (DUF669); Region: DUF669; pfam05037 1001583006154 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1001583006155 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1001583006156 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1001583006157 ATP binding site [chemical binding]; other site 1001583006158 putative Mg++ binding site [ion binding]; other site 1001583006159 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001583006160 nucleotide binding region [chemical binding]; other site 1001583006161 ATP-binding site [chemical binding]; other site 1001583006162 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 1001583006163 AAA domain; Region: AAA_24; pfam13479 1001583006164 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 1001583006165 Prophage antirepressor [Transcription]; Region: COG3617 1001583006166 BRO family, N-terminal domain; Region: Bro-N; smart01040 1001583006167 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1001583006168 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1001583006169 non-specific DNA binding site [nucleotide binding]; other site 1001583006170 salt bridge; other site 1001583006171 sequence-specific DNA binding site [nucleotide binding]; other site 1001583006172 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1001583006173 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001583006174 non-specific DNA binding site [nucleotide binding]; other site 1001583006175 salt bridge; other site 1001583006176 sequence-specific DNA binding site [nucleotide binding]; other site 1001583006177 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1001583006178 Predicted membrane protein (DUF2335); Region: DUF2335; pfam10097 1001583006179 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1001583006180 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1001583006181 Int/Topo IB signature motif; other site 1001583006182 MarR family; Region: MarR_2; cl17246 1001583006183 MarR family; Region: MarR_2; cl17246 1001583006184 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1001583006185 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001583006186 dimerization interface [polypeptide binding]; other site 1001583006187 putative DNA binding site [nucleotide binding]; other site 1001583006188 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1001583006189 putative Zn2+ binding site [ion binding]; other site 1001583006190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583006191 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001583006192 putative substrate translocation pore; other site 1001583006193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583006194 putative substrate translocation pore; other site 1001583006195 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1001583006196 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1001583006197 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1001583006198 active site 1001583006199 NlpC/P60 family; Region: NLPC_P60; pfam00877 1001583006200 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1001583006201 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1001583006202 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583006203 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583006204 Integrase core domain; Region: rve; pfam00665 1001583006205 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1001583006206 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1001583006207 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1001583006208 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001583006209 non-specific DNA binding site [nucleotide binding]; other site 1001583006210 salt bridge; other site 1001583006211 sequence-specific DNA binding site [nucleotide binding]; other site 1001583006212 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1001583006213 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1001583006214 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1001583006215 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1001583006216 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1001583006217 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1001583006218 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1001583006219 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1001583006220 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1001583006221 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1001583006222 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1001583006223 active site 1001583006224 metal binding site [ion binding]; metal-binding site 1001583006225 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1001583006226 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1001583006227 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1001583006228 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1001583006229 active site 1001583006230 tetramer interface [polypeptide binding]; other site 1001583006231 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1001583006232 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1001583006233 DNA binding site [nucleotide binding] 1001583006234 domain linker motif; other site 1001583006235 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1001583006236 dimerization interface [polypeptide binding]; other site 1001583006237 ligand binding site [chemical binding]; other site 1001583006238 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1001583006239 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1001583006240 hypothetical protein; Provisional; Region: PRK13690 1001583006241 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 1001583006242 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1001583006243 dimer interface [polypeptide binding]; other site 1001583006244 substrate binding site [chemical binding]; other site 1001583006245 ATP binding site [chemical binding]; other site 1001583006246 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1001583006247 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001583006248 DNA-binding site [nucleotide binding]; DNA binding site 1001583006249 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1001583006250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001583006251 homodimer interface [polypeptide binding]; other site 1001583006252 catalytic residue [active] 1001583006253 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1001583006254 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1001583006255 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1001583006256 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1001583006257 Walker A/P-loop; other site 1001583006258 ATP binding site [chemical binding]; other site 1001583006259 Q-loop/lid; other site 1001583006260 ABC transporter signature motif; other site 1001583006261 Walker B; other site 1001583006262 D-loop; other site 1001583006263 H-loop/switch region; other site 1001583006264 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 1001583006265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001583006266 dimer interface [polypeptide binding]; other site 1001583006267 conserved gate region; other site 1001583006268 ABC-ATPase subunit interface; other site 1001583006269 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1001583006270 Predicted transcriptional regulators [Transcription]; Region: COG1733 1001583006271 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1001583006272 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1001583006273 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1001583006274 active site 1001583006275 metal binding site [ion binding]; metal-binding site 1001583006276 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 1001583006277 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1001583006278 putative NAD(P) binding site [chemical binding]; other site 1001583006279 catalytic Zn binding site [ion binding]; other site 1001583006280 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1001583006281 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1001583006282 nucleotide binding site [chemical binding]; other site 1001583006283 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1001583006284 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1001583006285 dimer interface [polypeptide binding]; other site 1001583006286 active site 1001583006287 metal binding site [ion binding]; metal-binding site 1001583006288 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1001583006289 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1001583006290 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1001583006291 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1001583006292 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1001583006293 catalytic core [active] 1001583006294 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1001583006295 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1001583006296 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1001583006297 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1001583006298 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1001583006299 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1001583006300 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1001583006301 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1001583006302 peptide binding site [polypeptide binding]; other site 1001583006303 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1001583006304 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1001583006305 DNA binding site [nucleotide binding] 1001583006306 domain linker motif; other site 1001583006307 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1001583006308 dimerization interface [polypeptide binding]; other site 1001583006309 ligand binding site [chemical binding]; other site 1001583006310 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001583006311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583006312 putative substrate translocation pore; other site 1001583006313 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1001583006314 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1001583006315 Ca binding site [ion binding]; other site 1001583006316 active site 1001583006317 catalytic site [active] 1001583006318 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1001583006319 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1001583006320 DNA binding residues [nucleotide binding] 1001583006321 putative dimer interface [polypeptide binding]; other site 1001583006322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1001583006323 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1001583006324 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1001583006325 putative active site [active] 1001583006326 putative FMN binding site [chemical binding]; other site 1001583006327 putative substrate binding site [chemical binding]; other site 1001583006328 putative catalytic residue [active] 1001583006329 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 1001583006330 Predicted transcriptional regulators [Transcription]; Region: COG1733 1001583006331 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1001583006332 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1001583006333 putative dimer interface [polypeptide binding]; other site 1001583006334 catalytic triad [active] 1001583006335 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1001583006336 active site 1001583006337 tetramer interface [polypeptide binding]; other site 1001583006338 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 1001583006339 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1001583006340 ligand binding site [chemical binding]; other site 1001583006341 flexible hinge region; other site 1001583006342 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1001583006343 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1001583006344 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583006345 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583006346 Integrase core domain; Region: rve; pfam00665 1001583006347 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1001583006348 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1001583006349 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1001583006350 Cation efflux family; Region: Cation_efflux; pfam01545 1001583006351 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1001583006352 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1001583006353 dimer interface [polypeptide binding]; other site 1001583006354 active site 1001583006355 metal binding site [ion binding]; metal-binding site 1001583006356 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1001583006357 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001583006358 motif II; other site 1001583006359 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1001583006360 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 1001583006361 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1001583006362 substrate binding site [chemical binding]; other site 1001583006363 D-galactonate transporter; Region: 2A0114; TIGR00893 1001583006364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583006365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583006366 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1001583006367 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1001583006368 Walker A/P-loop; other site 1001583006369 ATP binding site [chemical binding]; other site 1001583006370 Q-loop/lid; other site 1001583006371 ABC transporter signature motif; other site 1001583006372 Walker B; other site 1001583006373 D-loop; other site 1001583006374 H-loop/switch region; other site 1001583006375 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1001583006376 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1001583006377 FtsX-like permease family; Region: FtsX; pfam02687 1001583006378 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001583006379 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001583006380 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1001583006381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583006382 Domain of unknown function (DUF386); Region: DUF386; cl01047 1001583006383 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1001583006384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583006385 putative substrate translocation pore; other site 1001583006386 Domain of unknown function (DUF386); Region: DUF386; cl01047 1001583006387 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1001583006388 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1001583006389 intersubunit interface [polypeptide binding]; other site 1001583006390 active site 1001583006391 Zn2+ binding site [ion binding]; other site 1001583006392 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 1001583006393 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1001583006394 AP (apurinic/apyrimidinic) site pocket; other site 1001583006395 DNA interaction; other site 1001583006396 Metal-binding active site; metal-binding site 1001583006397 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1001583006398 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1001583006399 putative N- and C-terminal domain interface [polypeptide binding]; other site 1001583006400 putative active site [active] 1001583006401 MgATP binding site [chemical binding]; other site 1001583006402 catalytic site [active] 1001583006403 metal binding site [ion binding]; metal-binding site 1001583006404 putative xylulose binding site [chemical binding]; other site 1001583006405 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1001583006406 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1001583006407 NAD binding site [chemical binding]; other site 1001583006408 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1001583006409 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1001583006410 DNA binding site [nucleotide binding] 1001583006411 domain linker motif; other site 1001583006412 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1001583006413 putative dimerization interface [polypeptide binding]; other site 1001583006414 putative ligand binding site [chemical binding]; other site 1001583006415 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 1001583006416 Membrane transport protein; Region: Mem_trans; cl09117 1001583006417 malate dehydrogenase; Provisional; Region: PRK13529 1001583006418 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1001583006419 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1001583006420 NAD(P) binding site [chemical binding]; other site 1001583006421 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1001583006422 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001583006423 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1001583006424 dimerization interface [polypeptide binding]; other site 1001583006425 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1001583006426 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1001583006427 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1001583006428 putative active site [active] 1001583006429 agmatine deiminase; Region: agmatine_aguA; TIGR03380 1001583006430 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1001583006431 carbamate kinase; Reviewed; Region: PRK12686 1001583006432 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1001583006433 putative substrate binding site [chemical binding]; other site 1001583006434 nucleotide binding site [chemical binding]; other site 1001583006435 nucleotide binding site [chemical binding]; other site 1001583006436 homodimer interface [polypeptide binding]; other site 1001583006437 agmatine deiminase; Provisional; Region: PRK13551 1001583006438 agmatine deiminase; Region: agmatine_aguA; TIGR03380 1001583006439 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1001583006440 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1001583006441 putrescine carbamoyltransferase; Provisional; Region: PRK02255 1001583006442 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1001583006443 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1001583006444 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1001583006445 Chromate transporter; Region: Chromate_transp; cl17781 1001583006446 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 1001583006447 tyrosine decarboxylase, Enterococcus type; Region: tyr_de_CO2_Ent; TIGR03811 1001583006448 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1001583006449 catalytic residue [active] 1001583006450 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1001583006451 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1001583006452 active site 1001583006453 HIGH motif; other site 1001583006454 dimer interface [polypeptide binding]; other site 1001583006455 KMSKS motif; other site 1001583006456 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1001583006457 RNA binding surface [nucleotide binding]; other site 1001583006458 putative acyltransferase; Provisional; Region: PRK05790 1001583006459 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1001583006460 dimer interface [polypeptide binding]; other site 1001583006461 active site 1001583006462 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1001583006463 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1001583006464 CsbD-like; Region: CsbD; cl17424 1001583006465 Predicted membrane protein [Function unknown]; Region: COG2261 1001583006466 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1001583006467 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1001583006468 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1001583006469 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1001583006470 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1001583006471 Protein of unknown function (DUF328); Region: DUF328; pfam03883 1001583006472 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001583006473 active site 1001583006474 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1001583006475 active site 1001583006476 dimer interface [polypeptide binding]; other site 1001583006477 benzoate transport; Region: 2A0115; TIGR00895 1001583006478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583006479 putative substrate translocation pore; other site 1001583006480 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 1001583006481 Protein of unknown function; Region: DUF3658; pfam12395 1001583006482 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1001583006483 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1001583006484 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1001583006485 substrate binding site [chemical binding]; other site 1001583006486 ATP binding site [chemical binding]; other site 1001583006487 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1001583006488 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1001583006489 Na binding site [ion binding]; other site 1001583006490 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1001583006491 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001583006492 DNA-binding site [nucleotide binding]; DNA binding site 1001583006493 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1001583006494 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1001583006495 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1001583006496 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1001583006497 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1001583006498 catalytic triad [active] 1001583006499 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1001583006500 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1001583006501 G1 box; other site 1001583006502 putative GEF interaction site [polypeptide binding]; other site 1001583006503 GTP/Mg2+ binding site [chemical binding]; other site 1001583006504 Switch I region; other site 1001583006505 G2 box; other site 1001583006506 G3 box; other site 1001583006507 Switch II region; other site 1001583006508 G4 box; other site 1001583006509 G5 box; other site 1001583006510 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 1001583006511 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 1001583006512 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1001583006513 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1001583006514 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1001583006515 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001583006516 homodimer interface [polypeptide binding]; other site 1001583006517 catalytic residue [active] 1001583006518 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001583006519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583006520 putative substrate translocation pore; other site 1001583006521 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1001583006522 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1001583006523 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 1001583006524 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1001583006525 active site 1001583006526 substrate binding site [chemical binding]; other site 1001583006527 trimer interface [polypeptide binding]; other site 1001583006528 CoA binding site [chemical binding]; other site 1001583006529 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1001583006530 active site 1001583006531 zinc binding site [ion binding]; other site 1001583006532 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1001583006533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1001583006534 Walker A motif; other site 1001583006535 ATP binding site [chemical binding]; other site 1001583006536 Walker B motif; other site 1001583006537 Uncharacterized conserved protein [Function unknown]; Region: COG3410 1001583006538 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001583006539 non-specific DNA binding site [nucleotide binding]; other site 1001583006540 salt bridge; other site 1001583006541 sequence-specific DNA binding site [nucleotide binding]; other site 1001583006542 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1001583006543 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1001583006544 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1001583006545 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1001583006546 Predicted flavoprotein [General function prediction only]; Region: COG0431 1001583006547 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583006548 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583006549 Integrase core domain; Region: rve; pfam00665 1001583006550 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583006551 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583006552 Homeodomain-like domain; Region: HTH_32; pfam13565 1001583006553 Integrase core domain; Region: rve; pfam00665 1001583006554 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1001583006555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001583006556 dimer interface [polypeptide binding]; other site 1001583006557 conserved gate region; other site 1001583006558 putative PBP binding loops; other site 1001583006559 ABC-ATPase subunit interface; other site 1001583006560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001583006561 dimer interface [polypeptide binding]; other site 1001583006562 conserved gate region; other site 1001583006563 putative PBP binding loops; other site 1001583006564 ABC-ATPase subunit interface; other site 1001583006565 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1001583006566 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1001583006567 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1001583006568 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1001583006569 Walker A/P-loop; other site 1001583006570 ATP binding site [chemical binding]; other site 1001583006571 Q-loop/lid; other site 1001583006572 ABC transporter signature motif; other site 1001583006573 Walker B; other site 1001583006574 D-loop; other site 1001583006575 H-loop/switch region; other site 1001583006576 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583006577 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583006578 Integrase core domain; Region: rve; pfam00665 1001583006579 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 1001583006580 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1001583006581 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1001583006582 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1001583006583 Predicted transcriptional regulator [Transcription]; Region: COG1959 1001583006584 Transcriptional regulator; Region: Rrf2; pfam02082 1001583006585 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1001583006586 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1001583006587 NADP binding site [chemical binding]; other site 1001583006588 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1001583006589 legume lectins; Region: lectin_L-type; cl14058 1001583006590 carbohydrate binding site [chemical binding]; other site 1001583006591 metal binding site [ion binding]; metal-binding site 1001583006592 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1001583006593 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1001583006594 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1001583006595 Part of AAA domain; Region: AAA_19; pfam13245 1001583006596 Family description; Region: UvrD_C_2; pfam13538 1001583006597 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1001583006598 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1001583006599 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1001583006600 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1001583006601 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1001583006602 metal binding site [ion binding]; metal-binding site 1001583006603 dimer interface [polypeptide binding]; other site 1001583006604 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1001583006605 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1001583006606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001583006607 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1001583006608 NAD(P) binding site [chemical binding]; other site 1001583006609 active site 1001583006610 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1001583006611 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1001583006612 active site 1001583006613 catalytic tetrad [active] 1001583006614 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1001583006615 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001583006616 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001583006617 putative Zn2+ binding site [ion binding]; other site 1001583006618 putative DNA binding site [nucleotide binding]; other site 1001583006619 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001583006620 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1001583006621 Walker A/P-loop; other site 1001583006622 ATP binding site [chemical binding]; other site 1001583006623 Q-loop/lid; other site 1001583006624 ABC transporter signature motif; other site 1001583006625 Walker B; other site 1001583006626 D-loop; other site 1001583006627 H-loop/switch region; other site 1001583006628 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1001583006629 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1001583006630 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1001583006631 UbiA prenyltransferase family; Region: UbiA; pfam01040 1001583006632 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1001583006633 QueT transporter; Region: QueT; pfam06177 1001583006634 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1001583006635 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1001583006636 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1001583006637 inhibitor binding site; inhibition site 1001583006638 active site 1001583006639 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 1001583006640 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1001583006641 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1001583006642 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1001583006643 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1001583006644 Helix-turn-helix domain; Region: HTH_18; pfam12833 1001583006645 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1001583006646 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1001583006647 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1001583006648 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1001583006649 putative active site [active] 1001583006650 catalytic site [active] 1001583006651 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1001583006652 putative active site [active] 1001583006653 catalytic site [active] 1001583006654 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 1001583006655 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1001583006656 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1001583006657 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1001583006658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001583006659 motif II; other site 1001583006660 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1001583006661 trimer interface [polypeptide binding]; other site 1001583006662 active site 1001583006663 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001583006664 MarR family; Region: MarR_2; pfam12802 1001583006665 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 1001583006666 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1001583006667 Catalytic site [active] 1001583006668 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1001583006669 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1001583006670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583006671 putative substrate translocation pore; other site 1001583006672 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 1001583006673 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1001583006674 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1001583006675 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1001583006676 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001583006677 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1001583006678 NAD(P) binding site [chemical binding]; other site 1001583006679 active site 1001583006680 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1001583006681 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1001583006682 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001583006683 motif II; other site 1001583006684 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1001583006685 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1001583006686 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1001583006687 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1001583006688 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1001583006689 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1001583006690 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1001583006691 G1 box; other site 1001583006692 GTP/Mg2+ binding site [chemical binding]; other site 1001583006693 Switch I region; other site 1001583006694 G2 box; other site 1001583006695 Switch II region; other site 1001583006696 G3 box; other site 1001583006697 G4 box; other site 1001583006698 G5 box; other site 1001583006699 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1001583006700 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1001583006701 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1001583006702 G-X-X-G motif; other site 1001583006703 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1001583006704 RxxxH motif; other site 1001583006705 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1001583006706 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1001583006707 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1001583006708 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1001583006709 DNA topoisomerase III; Provisional; Region: PRK07726 1001583006710 active site 1001583006711 putative interdomain interaction site [polypeptide binding]; other site 1001583006712 putative metal-binding site [ion binding]; other site 1001583006713 putative nucleotide binding site [chemical binding]; other site 1001583006714 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1001583006715 domain I; other site 1001583006716 DNA binding groove [nucleotide binding] 1001583006717 phosphate binding site [ion binding]; other site 1001583006718 domain II; other site 1001583006719 domain III; other site 1001583006720 nucleotide binding site [chemical binding]; other site 1001583006721 catalytic site [active] 1001583006722 domain IV; other site 1001583006723 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1001583006724 Integrase core domain; Region: rve; pfam00665 1001583006725 DDE domain; Region: DDE_Tnp_IS240; pfam13610 1001583006726 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 1001583006727 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1001583006728 Walker A motif; other site 1001583006729 ATP binding site [chemical binding]; other site 1001583006730 Walker B motif; other site 1001583006731 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1001583006732 catalytic residues [active] 1001583006733 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1001583006734 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1001583006735 catalytic residue [active] 1001583006736 NlpC/P60 family; Region: NLPC_P60; cl17555 1001583006737 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 1001583006738 AAA-like domain; Region: AAA_10; pfam12846 1001583006739 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1001583006740 G1 box; other site 1001583006741 GTP/Mg2+ binding site [chemical binding]; other site 1001583006742 Switch I region; other site 1001583006743 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 1001583006744 MobA/MobL family; Region: MobA_MobL; pfam03389 1001583006745 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 1001583006746 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1001583006747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1001583006748 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 1001583006749 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1001583006750 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1001583006751 P-loop; other site 1001583006752 Magnesium ion binding site [ion binding]; other site 1001583006753 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1001583006754 Magnesium ion binding site [ion binding]; other site 1001583006755 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583006756 Integrase core domain; Region: rve; pfam00665 1001583006757 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1001583006758 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1001583006759 catalytic residues [active] 1001583006760 catalytic nucleophile [active] 1001583006761 Presynaptic Site I dimer interface [polypeptide binding]; other site 1001583006762 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1001583006763 Synaptic Flat tetramer interface [polypeptide binding]; other site 1001583006764 Synaptic Site I dimer interface [polypeptide binding]; other site 1001583006765 DNA binding site [nucleotide binding] 1001583006766 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1001583006767 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1001583006768 Putative Catalytic site; other site 1001583006769 DXD motif; other site 1001583006770 Predicted membrane protein [Function unknown]; Region: COG2246 1001583006771 GtrA-like protein; Region: GtrA; pfam04138 1001583006772 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1001583006773 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1001583006774 DXD motif; other site 1001583006775 PilZ domain; Region: PilZ; pfam07238 1001583006776 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1001583006777 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1001583006778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001583006779 Walker A/P-loop; other site 1001583006780 ATP binding site [chemical binding]; other site 1001583006781 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1001583006782 putative active site [active] 1001583006783 putative metal-binding site [ion binding]; other site 1001583006784 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1001583006785 Part of AAA domain; Region: AAA_19; pfam13245 1001583006786 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1001583006787 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1001583006788 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1001583006789 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1001583006790 Domain of unknown function (DUF955); Region: DUF955; cl01076 1001583006791 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1001583006792 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1001583006793 P-loop; other site 1001583006794 Magnesium ion binding site [ion binding]; other site 1001583006795 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1001583006796 Magnesium ion binding site [ion binding]; other site 1001583006797 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583006798 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1001583006799 Integrase core domain; Region: rve; pfam00665 1001583006800 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583006801 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583006802 Integrase core domain; Region: rve; pfam00665 1001583006803 K+ potassium transporter; Region: K_trans; pfam02705 1001583006804 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1001583006805 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1001583006806 catalytic residues [active] 1001583006807 catalytic nucleophile [active] 1001583006808 Presynaptic Site I dimer interface [polypeptide binding]; other site 1001583006809 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1001583006810 Synaptic Flat tetramer interface [polypeptide binding]; other site 1001583006811 Synaptic Site I dimer interface [polypeptide binding]; other site 1001583006812 DNA binding site [nucleotide binding] 1001583006813 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583006814 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1001583006815 MgtC family; Region: MgtC; pfam02308 1001583006816 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1001583006817 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1001583006818 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001583006819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583006820 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1001583006821 putative substrate translocation pore; other site 1001583006822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583006823 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583006824 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583006825 Integrase core domain; Region: rve; pfam00665 1001583006826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001583006827 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1001583006828 Walker A motif; other site 1001583006829 ATP binding site [chemical binding]; other site 1001583006830 Walker B motif; other site 1001583006831 arginine finger; other site 1001583006832 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001583006833 Walker A motif; other site 1001583006834 ATP binding site [chemical binding]; other site 1001583006835 Walker B motif; other site 1001583006836 arginine finger; other site 1001583006837 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1001583006838 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583006839 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583006840 Integrase core domain; Region: rve; pfam00665 1001583006841 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1001583006842 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1001583006843 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1001583006844 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1001583006845 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1001583006846 Cl- selectivity filter; other site 1001583006847 Cl- binding residues [ion binding]; other site 1001583006848 pore gating glutamate residue; other site 1001583006849 dimer interface [polypeptide binding]; other site 1001583006850 H+/Cl- coupling transport residue; other site 1001583006851 TrkA-C domain; Region: TrkA_C; pfam02080 1001583006852 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583006853 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583006854 Integrase core domain; Region: rve; pfam00665 1001583006855 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1001583006856 DNA topoisomerase III; Provisional; Region: PRK07726 1001583006857 active site 1001583006858 putative interdomain interaction site [polypeptide binding]; other site 1001583006859 putative metal-binding site [ion binding]; other site 1001583006860 putative nucleotide binding site [chemical binding]; other site 1001583006861 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1001583006862 domain I; other site 1001583006863 DNA binding groove [nucleotide binding] 1001583006864 phosphate binding site [ion binding]; other site 1001583006865 domain II; other site 1001583006866 domain III; other site 1001583006867 nucleotide binding site [chemical binding]; other site 1001583006868 catalytic site [active] 1001583006869 domain IV; other site 1001583006870 MobA/MobL family; Region: MobA_MobL; pfam03389 1001583006871 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 1001583006872 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1001583006873 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1001583006874 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1001583006875 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1001583006876 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1001583006877 Cl binding site [ion binding]; other site 1001583006878 oligomer interface [polypeptide binding]; other site 1001583006879 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583006880 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583006881 Integrase core domain; Region: rve; pfam00665 1001583006882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001583006883 Coenzyme A binding pocket [chemical binding]; other site 1001583006884 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1001583006885 active site 1001583006886 Helix-turn-helix domain; Region: HTH_28; pfam13518 1001583006887 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1001583006888 Transposase; Region: HTH_Tnp_1; cl17663 1001583006889 putative transposase OrfB; Reviewed; Region: PHA02517 1001583006890 HTH-like domain; Region: HTH_21; pfam13276 1001583006891 Integrase core domain; Region: rve; pfam00665 1001583006892 Integrase core domain; Region: rve_2; pfam13333 1001583006893 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1001583006894 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1001583006895 catalytic residues [active] 1001583006896 catalytic nucleophile [active] 1001583006897 Presynaptic Site I dimer interface [polypeptide binding]; other site 1001583006898 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1001583006899 Synaptic Flat tetramer interface [polypeptide binding]; other site 1001583006900 Synaptic Site I dimer interface [polypeptide binding]; other site 1001583006901 DNA binding site [nucleotide binding] 1001583006902 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1001583006903 DNA-binding interface [nucleotide binding]; DNA binding site 1001583006904 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583006905 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583006906 Integrase core domain; Region: rve; pfam00665 1001583006907 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1001583006908 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1001583006909 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583006910 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1001583006911 Integrase core domain; Region: rve; pfam00665 1001583006912 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1001583006913 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1001583006914 Magnesium ion binding site [ion binding]; other site 1001583006915 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 1001583006916 Dimer interface [polypeptide binding]; other site 1001583006917 BRCT sequence motif; other site 1001583006918 RelB antitoxin; Region: RelB; cl01171 1001583006919 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 1001583006920 MobA/MobL family; Region: MobA_MobL; pfam03389 1001583006921 Domain of unknown function (DUF955); Region: DUF955; cl01076 1001583006922 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1001583006923 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1001583006924 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1001583006925 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1001583006926 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1001583006927 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1001583006928 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1001583006929 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1001583006930 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1001583006931 ATP binding site [chemical binding]; other site 1001583006932 putative Mg++ binding site [ion binding]; other site 1001583006933 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1001583006934 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001583006935 non-specific DNA binding site [nucleotide binding]; other site 1001583006936 salt bridge; other site 1001583006937 sequence-specific DNA binding site [nucleotide binding]; other site 1001583006938 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 1001583006939 DNA polymerase IV; Reviewed; Region: PRK03103 1001583006940 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1001583006941 active site 1001583006942 DNA binding site [nucleotide binding] 1001583006943 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1001583006944 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1001583006945 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1001583006946 P-loop; other site 1001583006947 Magnesium ion binding site [ion binding]; other site 1001583006948 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1001583006949 Magnesium ion binding site [ion binding]; other site 1001583006950 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 1001583006951 Dimer interface [polypeptide binding]; other site 1001583006952 BRCT sequence motif; other site 1001583006953 RelB antitoxin; Region: RelB; cl01171 1001583006954 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 1001583006955 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1001583006956 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1001583006957 active site 1001583006958 DNA binding site [nucleotide binding] 1001583006959 Int/Topo IB signature motif; other site 1001583006960 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1001583006961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 1001583006962 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1001583006963 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1001583006964 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001583006965 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1001583006966 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1001583006967 catalytic residues [active] 1001583006968 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1001583006969 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1001583006970 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001583006971 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1001583006972 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1001583006973 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1001583006974 catalytic residues [active] 1001583006975 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1001583006976 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1001583006977 catalytic residues [active] 1001583006978 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1001583006979 catalytic residues [active] 1001583006980 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001583006981 dimerization interface [polypeptide binding]; other site 1001583006982 putative DNA binding site [nucleotide binding]; other site 1001583006983 putative Zn2+ binding site [ion binding]; other site 1001583006984 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1001583006985 active site residue [active] 1001583006986 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1001583006987 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1001583006988 dimerization interface [polypeptide binding]; other site 1001583006989 DPS ferroxidase diiron center [ion binding]; other site 1001583006990 ion pore; other site 1001583006991 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1001583006992 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1001583006993 Walker A/P-loop; other site 1001583006994 ATP binding site [chemical binding]; other site 1001583006995 Q-loop/lid; other site 1001583006996 ABC transporter signature motif; other site 1001583006997 Walker B; other site 1001583006998 D-loop; other site 1001583006999 H-loop/switch region; other site 1001583007000 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1001583007001 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1001583007002 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001583007003 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001583007004 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 1001583007005 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1001583007006 Integrase core domain; Region: rve; pfam00665 1001583007007 Integrase core domain; Region: rve; pfam00665 1001583007008 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1001583007009 DNA binding site [nucleotide binding] 1001583007010 Int/Topo IB signature motif; other site 1001583007011 active site 1001583007012 Initiator Replication protein; Region: Rep_3; pfam01051 1001583007013 HTH domain; Region: HTH_11; cl17392 1001583007014 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1001583007015 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1001583007016 dimerization interface [polypeptide binding]; other site 1001583007017 DPS ferroxidase diiron center [ion binding]; other site 1001583007018 ion pore; other site 1001583007019 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1001583007020 active site 1001583007021 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 1001583007022 RelB antitoxin; Region: RelB; cl01171 1001583007023 MobA/MobL family; Region: MobA_MobL; pfam03389 1001583007024 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1001583007025 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001583007026 non-specific DNA binding site [nucleotide binding]; other site 1001583007027 salt bridge; other site 1001583007028 sequence-specific DNA binding site [nucleotide binding]; other site 1001583007029 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1001583007030 Helix-turn-helix domain; Region: HTH_38; pfam13936 1001583007031 Integrase core domain; Region: rve; pfam00665 1001583007032 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1001583007033 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1001583007034 catalytic residues [active] 1001583007035 catalytic nucleophile [active] 1001583007036 Presynaptic Site I dimer interface [polypeptide binding]; other site 1001583007037 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1001583007038 Synaptic Flat tetramer interface [polypeptide binding]; other site 1001583007039 Synaptic Site I dimer interface [polypeptide binding]; other site 1001583007040 DNA binding site [nucleotide binding] 1001583007041 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1001583007042 DNA-binding interface [nucleotide binding]; DNA binding site 1001583007043 AAA domain; Region: AAA_13; pfam13166 1001583007044 MarR family; Region: MarR_2; pfam12802 1001583007045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583007046 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1001583007047 putative substrate translocation pore; other site 1001583007048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001583007049 Cation efflux family; Region: Cation_efflux; pfam01545 1001583007050 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1001583007051 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1001583007052 Resolvase, N terminal domain; Region: Resolvase; pfam00239 1001583007053 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1001583007054 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1001583007055 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1001583007056 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1001583007057 acyl-activating enzyme (AAE) consensus motif; other site 1001583007058 AMP binding site [chemical binding]; other site 1001583007059 active site 1001583007060 CoA binding site [chemical binding]; other site 1001583007061 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1001583007062 Condensation domain; Region: Condensation; pfam00668 1001583007063 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1001583007064 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1001583007065 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1001583007066 acyl-activating enzyme (AAE) consensus motif; other site 1001583007067 AMP binding site [chemical binding]; other site 1001583007068 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001583007069 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1001583007070 putative FMN binding site [chemical binding]; other site 1001583007071 NADPH bind site [chemical binding]; other site 1001583007072 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1001583007073 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1001583007074 Domain of unknown function (DUF955); Region: DUF955; cl01076 1001583007075 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 1001583007076 domain III; other site 1001583007077 nucleotide binding site [chemical binding]; other site 1001583007078 DNA binding groove [nucleotide binding] 1001583007079 catalytic site [active] 1001583007080 domain II; other site 1001583007081 domain IV; other site 1001583007082 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1001583007083 active site 1001583007084 putative interdomain interaction site [polypeptide binding]; other site 1001583007085 putative metal-binding site [ion binding]; other site 1001583007086 putative nucleotide binding site [chemical binding]; other site 1001583007087 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1001583007088 domain I; other site 1001583007089 phosphate binding site [ion binding]; other site 1001583007090 MobA/MobL family; Region: MobA_MobL; pfam03389 1001583007091 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 1001583007092 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 1001583007093 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1001583007094 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1001583007095 P-loop; other site 1001583007096 Magnesium ion binding site [ion binding]; other site 1001583007097 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1001583007098 Magnesium ion binding site [ion binding]; other site 1001583007099 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001583007100 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001583007101 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1001583007102 Helix-turn-helix domain; Region: HTH_17; pfam12728 1001583007103 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 1001583007104 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 1001583007105 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 1001583007106 putative active site [active] 1001583007107 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1001583007108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001583007109 Walker A/P-loop; other site 1001583007110 ATP binding site [chemical binding]; other site 1001583007111 Q-loop/lid; other site 1001583007112 ABC transporter signature motif; other site 1001583007113 Walker B; other site 1001583007114 D-loop; other site 1001583007115 H-loop/switch region; other site 1001583007116 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 1001583007117 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1001583007118 catalytic residues [active] 1001583007119 MobA/MobL family; Region: MobA_MobL; pfam03389 1001583007120 Initiator Replication protein; Region: Rep_3; pfam01051 1001583007121 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167