-- dump date 20140619_122648 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1071400000001 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1071400000002 Plasmid replication protein; Region: Rep_2; pfam01719 1071400000003 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 1071400000004 Replication protein; Region: Rep_1; pfam01446 1071400000005 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 1071400000006 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1071400000007 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1071400000008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1071400000009 Walker A motif; other site 1071400000010 ATP binding site [chemical binding]; other site 1071400000011 Walker B motif; other site 1071400000012 arginine finger; other site 1071400000013 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1071400000014 DnaA box-binding interface [nucleotide binding]; other site 1071400000015 DNA polymerase III subunit beta; Validated; Region: PRK05643 1071400000016 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1071400000017 putative DNA binding surface [nucleotide binding]; other site 1071400000018 dimer interface [polypeptide binding]; other site 1071400000019 beta-clamp/clamp loader binding surface; other site 1071400000020 beta-clamp/translesion DNA polymerase binding surface; other site 1071400000021 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1071400000022 recombination protein F; Reviewed; Region: recF; PRK00064 1071400000023 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1071400000024 Walker A/P-loop; other site 1071400000025 ATP binding site [chemical binding]; other site 1071400000026 Q-loop/lid; other site 1071400000027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1071400000028 ABC transporter signature motif; other site 1071400000029 Walker B; other site 1071400000030 D-loop; other site 1071400000031 H-loop/switch region; other site 1071400000032 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1071400000033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1071400000034 Mg2+ binding site [ion binding]; other site 1071400000035 G-X-G motif; other site 1071400000036 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1071400000037 anchoring element; other site 1071400000038 dimer interface [polypeptide binding]; other site 1071400000039 ATP binding site [chemical binding]; other site 1071400000040 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1071400000041 active site 1071400000042 putative metal-binding site [ion binding]; other site 1071400000043 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1071400000044 DNA gyrase subunit A; Validated; Region: PRK05560 1071400000045 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1071400000046 CAP-like domain; other site 1071400000047 active site 1071400000048 primary dimer interface [polypeptide binding]; other site 1071400000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1071400000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1071400000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1071400000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1071400000053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1071400000054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1071400000055 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 1071400000056 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 1071400000057 active site 1071400000058 teramer interface [polypeptide binding]; other site 1071400000059 FMN binding site [chemical binding]; other site 1071400000060 catalytic residues [active] 1071400000061 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1071400000062 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1071400000063 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1071400000064 dimer interface [polypeptide binding]; other site 1071400000065 ssDNA binding site [nucleotide binding]; other site 1071400000066 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1071400000067 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1071400000068 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1071400000069 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1071400000070 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1071400000071 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1071400000072 DHH family; Region: DHH; pfam01368 1071400000073 DHHA1 domain; Region: DHHA1; pfam02272 1071400000074 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1071400000075 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1071400000076 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1071400000077 replicative DNA helicase; Provisional; Region: PRK05748 1071400000078 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1071400000079 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1071400000080 Walker A motif; other site 1071400000081 ATP binding site [chemical binding]; other site 1071400000082 Walker B motif; other site 1071400000083 DNA binding loops [nucleotide binding] 1071400000084 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1071400000085 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1071400000086 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1071400000087 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1071400000088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1071400000089 active site 1071400000090 phosphorylation site [posttranslational modification] 1071400000091 intermolecular recognition site; other site 1071400000092 dimerization interface [polypeptide binding]; other site 1071400000093 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1071400000094 DNA binding site [nucleotide binding] 1071400000095 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1071400000096 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1071400000097 dimerization interface [polypeptide binding]; other site 1071400000098 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1071400000099 putative active site [active] 1071400000100 heme pocket [chemical binding]; other site 1071400000101 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1071400000102 dimer interface [polypeptide binding]; other site 1071400000103 phosphorylation site [posttranslational modification] 1071400000104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1071400000105 ATP binding site [chemical binding]; other site 1071400000106 Mg2+ binding site [ion binding]; other site 1071400000107 G-X-G motif; other site 1071400000108 YycH protein; Region: YycH; pfam07435 1071400000109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1071400000110 YycH protein; Region: YycI; pfam09648 1071400000111 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1071400000112 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1071400000113 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1071400000114 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1071400000115 protein binding site [polypeptide binding]; other site 1071400000116 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1071400000117 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1071400000118 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 1071400000119 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1071400000120 MarR family; Region: MarR_2; pfam12802 1071400000121 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 1071400000122 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1071400000123 putative ligand binding site [chemical binding]; other site 1071400000124 putative NAD binding site [chemical binding]; other site 1071400000125 catalytic site [active] 1071400000126 Predicted transcriptional regulators [Transcription]; Region: COG1733 1071400000127 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1071400000128 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1071400000129 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1071400000130 classical (c) SDRs; Region: SDR_c; cd05233 1071400000131 NAD(P) binding site [chemical binding]; other site 1071400000132 active site 1071400000133 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1071400000134 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1071400000135 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1071400000136 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1071400000137 peptide binding site [polypeptide binding]; other site 1071400000138 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1071400000139 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1071400000140 oligomer interface [polypeptide binding]; other site 1071400000141 active site 1071400000142 metal binding site [ion binding]; metal-binding site 1071400000143 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1071400000144 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1071400000145 catalytic triad [active] 1071400000146 putative alpha-glucosidase; Provisional; Region: PRK10658 1071400000147 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1071400000148 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 1071400000149 trimer interface [polypeptide binding]; other site 1071400000150 active site 1071400000151 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 1071400000152 catalytic site [active] 1071400000153 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 1071400000154 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1071400000155 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1071400000156 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1071400000157 active site 1071400000158 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1071400000159 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1071400000160 Amidohydrolase; Region: Amidohydro_4; pfam13147 1071400000161 active site 1071400000162 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1071400000163 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1071400000164 peptide binding site [polypeptide binding]; other site 1071400000165 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 1071400000166 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1071400000167 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1071400000168 formate dehydrogenase; Provisional; Region: PRK07574 1071400000169 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1071400000170 NAD binding site [chemical binding]; other site 1071400000171 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1071400000172 acetolactate synthase; Reviewed; Region: PRK08617 1071400000173 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1071400000174 PYR/PP interface [polypeptide binding]; other site 1071400000175 dimer interface [polypeptide binding]; other site 1071400000176 TPP binding site [chemical binding]; other site 1071400000177 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1071400000178 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1071400000179 TPP-binding site [chemical binding]; other site 1071400000180 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1071400000181 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1071400000182 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1071400000183 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1071400000184 DNA binding site [nucleotide binding] 1071400000185 domain linker motif; other site 1071400000186 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1071400000187 putative dimerization interface [polypeptide binding]; other site 1071400000188 putative ligand binding site [chemical binding]; other site 1071400000189 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1071400000190 Citrate transporter; Region: CitMHS; pfam03600 1071400000191 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1071400000192 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 1071400000193 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1071400000194 NADP binding site [chemical binding]; other site 1071400000195 homodimer interface [polypeptide binding]; other site 1071400000196 active site 1071400000197 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1071400000198 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 1071400000199 putative ligand binding site [chemical binding]; other site 1071400000200 putative NAD binding site [chemical binding]; other site 1071400000201 catalytic site [active] 1071400000202 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1071400000203 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1071400000204 active site 1071400000205 catalytic tetrad [active] 1071400000206 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1071400000207 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1071400000208 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1071400000209 dimerization interface [polypeptide binding]; other site 1071400000210 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1071400000211 Citrate transporter; Region: CitMHS; pfam03600 1071400000212 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1071400000213 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1071400000214 active site 1071400000215 tetramer interface [polypeptide binding]; other site 1071400000216 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1071400000217 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1071400000218 metal binding site [ion binding]; metal-binding site 1071400000219 substrate binding pocket [chemical binding]; other site 1071400000220 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1071400000221 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1071400000222 ligand binding site [chemical binding]; other site 1071400000223 NAD binding site [chemical binding]; other site 1071400000224 dimerization interface [polypeptide binding]; other site 1071400000225 catalytic site [active] 1071400000226 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1071400000227 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1071400000228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400000229 putative substrate translocation pore; other site 1071400000230 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400000231 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1071400000232 benzoate transport; Region: 2A0115; TIGR00895 1071400000233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400000234 putative substrate translocation pore; other site 1071400000235 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1071400000236 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1071400000237 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1071400000238 putative active site [active] 1071400000239 putative FMN binding site [chemical binding]; other site 1071400000240 putative substrate binding site [chemical binding]; other site 1071400000241 putative catalytic residue [active] 1071400000242 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1071400000243 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1071400000244 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1071400000245 substrate binding site [chemical binding]; other site 1071400000246 ATP binding site [chemical binding]; other site 1071400000247 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1071400000248 phosphate binding site [ion binding]; other site 1071400000249 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1071400000250 tetramer interface [polypeptide binding]; other site 1071400000251 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1071400000252 active site 1071400000253 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1071400000254 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1071400000255 active site 1071400000256 intersubunit interface [polypeptide binding]; other site 1071400000257 catalytic residue [active] 1071400000258 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1071400000259 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1071400000260 DNA binding site [nucleotide binding] 1071400000261 domain linker motif; other site 1071400000262 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1071400000263 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1071400000264 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1071400000265 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1071400000266 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1071400000267 peptide binding site [polypeptide binding]; other site 1071400000268 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1071400000269 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1071400000270 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1071400000271 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1071400000272 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1071400000273 active site 1071400000274 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1071400000275 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1071400000276 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1071400000277 active site 1071400000278 hypothetical protein; Provisional; Region: PRK06446 1071400000279 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 1071400000280 metal binding site [ion binding]; metal-binding site 1071400000281 dimer interface [polypeptide binding]; other site 1071400000282 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1071400000283 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1071400000284 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1071400000285 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1071400000286 Walker A/P-loop; other site 1071400000287 ATP binding site [chemical binding]; other site 1071400000288 Q-loop/lid; other site 1071400000289 ABC transporter signature motif; other site 1071400000290 Walker B; other site 1071400000291 D-loop; other site 1071400000292 H-loop/switch region; other site 1071400000293 NIL domain; Region: NIL; pfam09383 1071400000294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1071400000295 dimer interface [polypeptide binding]; other site 1071400000296 conserved gate region; other site 1071400000297 ABC-ATPase subunit interface; other site 1071400000298 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1071400000299 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1071400000300 metal binding site [ion binding]; metal-binding site 1071400000301 dimer interface [polypeptide binding]; other site 1071400000302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400000303 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400000304 putative substrate translocation pore; other site 1071400000305 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1071400000306 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1071400000307 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1071400000308 membrane protein FdrA; Validated; Region: PRK06091 1071400000309 CoA binding domain; Region: CoA_binding; pfam02629 1071400000310 CoA-ligase; Region: Ligase_CoA; pfam00549 1071400000311 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1071400000312 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 1071400000313 carbamate kinase; Reviewed; Region: PRK12686 1071400000314 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1071400000315 putative substrate binding site [chemical binding]; other site 1071400000316 nucleotide binding site [chemical binding]; other site 1071400000317 nucleotide binding site [chemical binding]; other site 1071400000318 homodimer interface [polypeptide binding]; other site 1071400000319 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1071400000320 cytosine deaminase; Provisional; Region: PRK05985 1071400000321 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1071400000322 active site 1071400000323 Helix-turn-helix domain; Region: HTH_38; pfam13936 1071400000324 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1071400000325 Homeodomain-like domain; Region: HTH_32; pfam13565 1071400000326 Integrase core domain; Region: rve; pfam00665 1071400000327 helicase Cas3; Provisional; Region: PRK09694 1071400000328 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1071400000329 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1071400000330 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 1071400000331 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 1071400000332 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 1071400000333 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1071400000334 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 1071400000335 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 1071400000336 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 1071400000337 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 1071400000338 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1071400000339 active site 1071400000340 catalytic site [active] 1071400000341 substrate binding site [chemical binding]; other site 1071400000342 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1071400000343 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1071400000344 amidase; Provisional; Region: PRK06529 1071400000345 Amidase; Region: Amidase; cl11426 1071400000346 Ion transport protein; Region: Ion_trans; pfam00520 1071400000347 Ion channel; Region: Ion_trans_2; pfam07885 1071400000348 Src homology 2 (SH2) domain; Region: SH2; cl15255 1071400000349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1071400000350 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional; Region: PRK11331 1071400000351 Walker A motif; other site 1071400000352 ATP binding site [chemical binding]; other site 1071400000353 Walker B motif; other site 1071400000354 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 1071400000355 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1071400000356 homodimer interface [polypeptide binding]; other site 1071400000357 chemical substrate binding site [chemical binding]; other site 1071400000358 oligomer interface [polypeptide binding]; other site 1071400000359 metal binding site [ion binding]; metal-binding site 1071400000360 GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439 1071400000361 GIY-YIG motif/motif A; other site 1071400000362 putative active site [active] 1071400000363 putative metal binding site [ion binding]; other site 1071400000364 AAA ATPase domain; Region: AAA_16; pfam13191 1071400000365 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1071400000366 Uncharacterized conserved protein [Function unknown]; Region: COG3410 1071400000367 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1071400000368 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1071400000369 active site 1071400000370 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1071400000371 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1071400000372 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1071400000373 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1071400000374 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1071400000375 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1071400000376 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1071400000377 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 1071400000378 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1071400000379 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1071400000380 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1071400000381 peptidase domain interface [polypeptide binding]; other site 1071400000382 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1071400000383 active site 1071400000384 catalytic residues [active] 1071400000385 SH3-like domain; Region: SH3_8; pfam13457 1071400000386 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1071400000387 Beta-lactamase; Region: Beta-lactamase; pfam00144 1071400000388 Beta-lactamase; Region: Beta-lactamase; pfam00144 1071400000389 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1071400000390 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1071400000391 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1071400000392 acyl-activating enzyme (AAE) consensus motif; other site 1071400000393 AMP binding site [chemical binding]; other site 1071400000394 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1071400000395 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1071400000396 DltD N-terminal region; Region: DltD_N; pfam04915 1071400000397 DltD central region; Region: DltD_M; pfam04918 1071400000398 DltD C-terminal region; Region: DltD_C; pfam04914 1071400000399 SH3-like domain; Region: SH3_8; pfam13457 1071400000400 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1071400000401 Beta-lactamase; Region: Beta-lactamase; pfam00144 1071400000402 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1071400000403 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1071400000404 Walker A/P-loop; other site 1071400000405 ATP binding site [chemical binding]; other site 1071400000406 Q-loop/lid; other site 1071400000407 ABC transporter signature motif; other site 1071400000408 Walker B; other site 1071400000409 D-loop; other site 1071400000410 H-loop/switch region; other site 1071400000411 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1071400000412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1071400000413 active site 1071400000414 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1071400000415 CrcB-like protein; Region: CRCB; cl09114 1071400000416 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1071400000417 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1071400000418 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1071400000419 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1071400000420 Predicted membrane protein [Function unknown]; Region: COG1288 1071400000421 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1071400000422 OsmC-like protein; Region: OsmC; pfam02566 1071400000423 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1071400000424 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1071400000425 peptide binding site [polypeptide binding]; other site 1071400000426 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1071400000427 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1071400000428 Ca binding site [ion binding]; other site 1071400000429 active site 1071400000430 catalytic site [active] 1071400000431 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1071400000432 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400000433 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 1071400000434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400000435 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1071400000436 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1071400000437 DNA binding site [nucleotide binding] 1071400000438 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1071400000439 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1071400000440 dimerization interface [polypeptide binding]; other site 1071400000441 ligand binding site [chemical binding]; other site 1071400000442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1071400000443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400000444 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 1071400000445 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 1071400000446 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1071400000447 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 1071400000448 catalytic Zn binding site [ion binding]; other site 1071400000449 NAD binding site [chemical binding]; other site 1071400000450 structural Zn binding site [ion binding]; other site 1071400000451 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 1071400000452 putative uracil binding site [chemical binding]; other site 1071400000453 putative active site [active] 1071400000454 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1071400000455 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1071400000456 active site 1071400000457 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1071400000458 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 1071400000459 active site 1071400000460 dimerization interface [polypeptide binding]; other site 1071400000461 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1071400000462 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1071400000463 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1071400000464 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1071400000465 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1071400000466 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1071400000467 active site 1071400000468 catalytic site [active] 1071400000469 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1071400000470 peptidase domain interface [polypeptide binding]; other site 1071400000471 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 1071400000472 active site 1071400000473 catalytic triad [active] 1071400000474 calcium binding site [ion binding]; other site 1071400000475 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1071400000476 sequence-specific DNA binding site [nucleotide binding]; other site 1071400000477 salt bridge; other site 1071400000478 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1071400000479 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1071400000480 Walker A/P-loop; other site 1071400000481 ATP binding site [chemical binding]; other site 1071400000482 Q-loop/lid; other site 1071400000483 ABC transporter signature motif; other site 1071400000484 Walker B; other site 1071400000485 D-loop; other site 1071400000486 H-loop/switch region; other site 1071400000487 TOBE domain; Region: TOBE_2; pfam08402 1071400000488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1071400000489 dimer interface [polypeptide binding]; other site 1071400000490 conserved gate region; other site 1071400000491 putative PBP binding loops; other site 1071400000492 ABC-ATPase subunit interface; other site 1071400000493 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1071400000494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1071400000495 dimer interface [polypeptide binding]; other site 1071400000496 conserved gate region; other site 1071400000497 putative PBP binding loops; other site 1071400000498 ABC-ATPase subunit interface; other site 1071400000499 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1071400000500 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1071400000501 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1071400000502 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1071400000503 active site 1071400000504 catalytic site [active] 1071400000505 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1071400000506 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1071400000507 peptide binding site [polypeptide binding]; other site 1071400000508 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1071400000509 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1071400000510 active site 1071400000511 catalytic tetrad [active] 1071400000512 Ferrochelatase; Region: Ferrochelatase; pfam00762 1071400000513 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1071400000514 C-terminal domain interface [polypeptide binding]; other site 1071400000515 active site 1071400000516 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1071400000517 active site 1071400000518 N-terminal domain interface [polypeptide binding]; other site 1071400000519 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1071400000520 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1071400000521 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1071400000522 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1071400000523 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1071400000524 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1071400000525 CAAX protease self-immunity; Region: Abi; pfam02517 1071400000526 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1071400000527 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1071400000528 DNA binding residues [nucleotide binding] 1071400000529 putative dimer interface [polypeptide binding]; other site 1071400000530 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1071400000531 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1071400000532 active site 1071400000533 catalytic tetrad [active] 1071400000534 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1071400000535 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1071400000536 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1071400000537 DNA binding residues [nucleotide binding] 1071400000538 DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874 1071400000539 Phosphotransferase enzyme family; Region: APH; pfam01636 1071400000540 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1071400000541 active site 1071400000542 ATP binding site [chemical binding]; other site 1071400000543 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1071400000544 substrate binding site [chemical binding]; other site 1071400000545 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 1071400000546 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1071400000547 putative active site [active] 1071400000548 putative FMN binding site [chemical binding]; other site 1071400000549 putative substrate binding site [chemical binding]; other site 1071400000550 putative catalytic residue [active] 1071400000551 L-aspartate oxidase; Provisional; Region: PRK06175 1071400000552 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 1071400000553 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1071400000554 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1071400000555 active site 1071400000556 catalytic tetrad [active] 1071400000557 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1071400000558 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1071400000559 dimerization interface [polypeptide binding]; other site 1071400000560 DPS ferroxidase diiron center [ion binding]; other site 1071400000561 ion pore; other site 1071400000562 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1071400000563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400000564 putative substrate translocation pore; other site 1071400000565 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1071400000566 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1071400000567 active site 1071400000568 motif I; other site 1071400000569 motif II; other site 1071400000570 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1071400000571 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1071400000572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400000573 putative substrate translocation pore; other site 1071400000574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400000575 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1071400000576 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1071400000577 potential catalytic triad [active] 1071400000578 conserved cys residue [active] 1071400000579 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1071400000580 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1071400000581 Walker A/P-loop; other site 1071400000582 ATP binding site [chemical binding]; other site 1071400000583 Q-loop/lid; other site 1071400000584 ABC transporter signature motif; other site 1071400000585 Walker B; other site 1071400000586 D-loop; other site 1071400000587 H-loop/switch region; other site 1071400000588 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1071400000589 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1071400000590 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1071400000591 active site 1071400000592 N-glycosyltransferase; Provisional; Region: PRK11204 1071400000593 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1071400000594 DXD motif; other site 1071400000595 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1071400000596 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 1071400000597 Predicted membrane protein [Function unknown]; Region: COG2323 1071400000598 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1071400000599 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1071400000600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1071400000601 homodimer interface [polypeptide binding]; other site 1071400000602 catalytic residue [active] 1071400000603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400000604 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400000605 putative substrate translocation pore; other site 1071400000606 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1071400000607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1071400000608 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1071400000609 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1071400000610 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1071400000611 glutamate dehydrogenase; Provisional; Region: PRK09414 1071400000612 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1071400000613 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1071400000614 NAD(P) binding site [chemical binding]; other site 1071400000615 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1071400000616 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1071400000617 substrate binding pocket [chemical binding]; other site 1071400000618 membrane-bound complex binding site; other site 1071400000619 hinge residues; other site 1071400000620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1071400000621 dimer interface [polypeptide binding]; other site 1071400000622 conserved gate region; other site 1071400000623 putative PBP binding loops; other site 1071400000624 ABC-ATPase subunit interface; other site 1071400000625 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1071400000626 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1071400000627 metal binding site [ion binding]; metal-binding site 1071400000628 dimer interface [polypeptide binding]; other site 1071400000629 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1071400000630 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1071400000631 metal binding site [ion binding]; metal-binding site 1071400000632 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1071400000633 Peptidase family M48; Region: Peptidase_M48; cl12018 1071400000634 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1071400000635 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1071400000636 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1071400000637 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1071400000638 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1071400000639 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1071400000640 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1071400000641 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1071400000642 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1071400000643 Prephenate dehydratase; Region: PDT; pfam00800 1071400000644 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1071400000645 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1071400000646 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1071400000647 pyruvate oxidase; Provisional; Region: PRK08611 1071400000648 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1071400000649 PYR/PP interface [polypeptide binding]; other site 1071400000650 dimer interface [polypeptide binding]; other site 1071400000651 tetramer interface [polypeptide binding]; other site 1071400000652 TPP binding site [chemical binding]; other site 1071400000653 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1071400000654 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1071400000655 TPP-binding site [chemical binding]; other site 1071400000656 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 1071400000657 short chain dehydrogenase; Provisional; Region: PRK06114 1071400000658 NADP binding site [chemical binding]; other site 1071400000659 substrate binding site [chemical binding]; other site 1071400000660 active site 1071400000661 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1071400000662 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1071400000663 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 1071400000664 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1071400000665 putative ligand binding site [chemical binding]; other site 1071400000666 putative NAD binding site [chemical binding]; other site 1071400000667 catalytic site [active] 1071400000668 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1071400000669 putative active site [active] 1071400000670 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1071400000671 Isochorismatase family; Region: Isochorismatase; pfam00857 1071400000672 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1071400000673 catalytic triad [active] 1071400000674 dimer interface [polypeptide binding]; other site 1071400000675 conserved cis-peptide bond; other site 1071400000676 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1071400000677 amidase catalytic site [active] 1071400000678 Zn binding residues [ion binding]; other site 1071400000679 substrate binding site [chemical binding]; other site 1071400000680 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 1071400000681 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1071400000682 metal binding site [ion binding]; metal-binding site 1071400000683 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1071400000684 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1071400000685 active site 1071400000686 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1071400000687 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1071400000688 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1071400000689 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1071400000690 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1071400000691 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1071400000692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1071400000693 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1071400000694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400000695 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400000696 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1071400000697 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1071400000698 DNA binding site [nucleotide binding] 1071400000699 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1071400000700 putative dimerization interface [polypeptide binding]; other site 1071400000701 putative ligand binding site [chemical binding]; other site 1071400000702 beta-D-glucuronidase; Provisional; Region: PRK10150 1071400000703 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1071400000704 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1071400000705 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1071400000706 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 1071400000707 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 1071400000708 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1071400000709 Coenzyme A binding pocket [chemical binding]; other site 1071400000710 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1071400000711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400000712 putative substrate translocation pore; other site 1071400000713 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1071400000714 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1071400000715 peptide binding site [polypeptide binding]; other site 1071400000716 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1071400000717 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1071400000718 catalytic triad [active] 1071400000719 EamA-like transporter family; Region: EamA; pfam00892 1071400000720 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1071400000721 EamA-like transporter family; Region: EamA; pfam00892 1071400000722 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1071400000723 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1071400000724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1071400000725 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1071400000726 NAD(P) binding site [chemical binding]; other site 1071400000727 active site 1071400000728 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1071400000729 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1071400000730 active site 1071400000731 catalytic tetrad [active] 1071400000732 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1071400000733 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1071400000734 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1071400000735 active site 1071400000736 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1071400000737 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1071400000738 catalytic triad [active] 1071400000739 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1071400000740 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1071400000741 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1071400000742 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1071400000743 Walker A/P-loop; other site 1071400000744 ATP binding site [chemical binding]; other site 1071400000745 Q-loop/lid; other site 1071400000746 ABC transporter signature motif; other site 1071400000747 Walker B; other site 1071400000748 D-loop; other site 1071400000749 H-loop/switch region; other site 1071400000750 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1071400000751 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1071400000752 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1071400000753 Walker A/P-loop; other site 1071400000754 ATP binding site [chemical binding]; other site 1071400000755 Q-loop/lid; other site 1071400000756 ABC transporter signature motif; other site 1071400000757 Walker B; other site 1071400000758 D-loop; other site 1071400000759 H-loop/switch region; other site 1071400000760 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1071400000761 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 1071400000762 putative dimer interface [polypeptide binding]; other site 1071400000763 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1071400000764 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 1071400000765 putative dimer interface [polypeptide binding]; other site 1071400000766 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1071400000767 active site 1071400000768 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1071400000769 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1071400000770 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1071400000771 dimer interface [polypeptide binding]; other site 1071400000772 FMN binding site [chemical binding]; other site 1071400000773 NADPH bind site [chemical binding]; other site 1071400000774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1071400000775 dimer interface [polypeptide binding]; other site 1071400000776 conserved gate region; other site 1071400000777 putative PBP binding loops; other site 1071400000778 ABC-ATPase subunit interface; other site 1071400000779 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1071400000780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1071400000781 dimer interface [polypeptide binding]; other site 1071400000782 conserved gate region; other site 1071400000783 putative PBP binding loops; other site 1071400000784 ABC-ATPase subunit interface; other site 1071400000785 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1071400000786 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1071400000787 Walker A/P-loop; other site 1071400000788 ATP binding site [chemical binding]; other site 1071400000789 Q-loop/lid; other site 1071400000790 ABC transporter signature motif; other site 1071400000791 Walker B; other site 1071400000792 D-loop; other site 1071400000793 H-loop/switch region; other site 1071400000794 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1071400000795 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1071400000796 substrate binding pocket [chemical binding]; other site 1071400000797 membrane-bound complex binding site; other site 1071400000798 hinge residues; other site 1071400000799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400000800 putative substrate translocation pore; other site 1071400000801 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400000802 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1071400000803 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1071400000804 active site 1071400000805 catalytic residue [active] 1071400000806 dimer interface [polypeptide binding]; other site 1071400000807 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1071400000808 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1071400000809 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1071400000810 peptide binding site [polypeptide binding]; other site 1071400000811 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1071400000812 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1071400000813 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1071400000814 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1071400000815 active site 1071400000816 Chorismate mutase type II; Region: CM_2; pfam01817 1071400000817 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1071400000818 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1071400000819 Tetramer interface [polypeptide binding]; other site 1071400000820 active site 1071400000821 FMN-binding site [chemical binding]; other site 1071400000822 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1071400000823 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1071400000824 hinge; other site 1071400000825 active site 1071400000826 Prephenate dehydrogenase; Region: PDH; pfam02153 1071400000827 prephenate dehydrogenase; Validated; Region: PRK08507 1071400000828 shikimate kinase; Reviewed; Region: aroK; PRK00131 1071400000829 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1071400000830 ADP binding site [chemical binding]; other site 1071400000831 magnesium binding site [ion binding]; other site 1071400000832 putative shikimate binding site; other site 1071400000833 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1071400000834 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1071400000835 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1071400000836 shikimate binding site; other site 1071400000837 NAD(P) binding site [chemical binding]; other site 1071400000838 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1071400000839 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 1071400000840 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1071400000841 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1071400000842 DNA binding site [nucleotide binding] 1071400000843 domain linker motif; other site 1071400000844 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1071400000845 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1071400000846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400000847 putative substrate translocation pore; other site 1071400000848 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1071400000849 HPr interaction site; other site 1071400000850 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1071400000851 active site 1071400000852 phosphorylation site [posttranslational modification] 1071400000853 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1071400000854 Melibiase; Region: Melibiase; pfam02065 1071400000855 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 1071400000856 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1071400000857 active site 1071400000858 substrate binding site [chemical binding]; other site 1071400000859 trimer interface [polypeptide binding]; other site 1071400000860 CoA binding site [chemical binding]; other site 1071400000861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400000862 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400000863 putative substrate translocation pore; other site 1071400000864 EDD domain protein, DegV family; Region: DegV; TIGR00762 1071400000865 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1071400000866 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1071400000867 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1071400000868 PemK-like protein; Region: PemK; cl00995 1071400000869 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1071400000870 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1071400000871 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1071400000872 Catalytic site [active] 1071400000873 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1071400000874 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1071400000875 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1071400000876 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1071400000877 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1071400000878 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1071400000879 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1071400000880 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1071400000881 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1071400000882 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1071400000883 catalytic site [active] 1071400000884 subunit interface [polypeptide binding]; other site 1071400000885 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1071400000886 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1071400000887 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1071400000888 dihydroorotase; Validated; Region: pyrC; PRK09357 1071400000889 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1071400000890 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1071400000891 active site 1071400000892 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1071400000893 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1071400000894 dimer interface [polypeptide binding]; other site 1071400000895 active site 1071400000896 ADP-ribose binding site [chemical binding]; other site 1071400000897 nudix motif; other site 1071400000898 metal binding site [ion binding]; metal-binding site 1071400000899 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1071400000900 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 1071400000901 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 1071400000902 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 1071400000903 putative ligand binding site [chemical binding]; other site 1071400000904 putative NAD binding site [chemical binding]; other site 1071400000905 putative catalytic site [active] 1071400000906 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1071400000907 L-serine binding site [chemical binding]; other site 1071400000908 ACT domain interface; other site 1071400000909 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 1071400000910 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1071400000911 catalytic residue [active] 1071400000912 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1071400000913 catalytic core [active] 1071400000914 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1071400000915 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1071400000916 peptide binding site [polypeptide binding]; other site 1071400000917 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1071400000918 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1071400000919 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1071400000920 NAD binding site [chemical binding]; other site 1071400000921 dimer interface [polypeptide binding]; other site 1071400000922 substrate binding site [chemical binding]; other site 1071400000923 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1071400000924 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1071400000925 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1071400000926 NAD binding site [chemical binding]; other site 1071400000927 dimer interface [polypeptide binding]; other site 1071400000928 substrate binding site [chemical binding]; other site 1071400000929 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1071400000930 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1071400000931 UbiA prenyltransferase family; Region: UbiA; pfam01040 1071400000932 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1071400000933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1071400000934 S-adenosylmethionine binding site [chemical binding]; other site 1071400000935 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1071400000936 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1071400000937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1071400000938 homodimer interface [polypeptide binding]; other site 1071400000939 catalytic residue [active] 1071400000940 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1071400000941 D-lactate dehydrogenase; Validated; Region: PRK08605 1071400000942 homodimer interface [polypeptide binding]; other site 1071400000943 ligand binding site [chemical binding]; other site 1071400000944 NAD binding site [chemical binding]; other site 1071400000945 catalytic site [active] 1071400000946 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1071400000947 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1071400000948 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1071400000949 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1071400000950 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 1071400000951 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1071400000952 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1071400000953 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1071400000954 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1071400000955 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1071400000956 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1071400000957 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1071400000958 Walker A/P-loop; other site 1071400000959 ATP binding site [chemical binding]; other site 1071400000960 Q-loop/lid; other site 1071400000961 ABC transporter signature motif; other site 1071400000962 Walker B; other site 1071400000963 D-loop; other site 1071400000964 H-loop/switch region; other site 1071400000965 Abi-like protein; Region: Abi_2; pfam07751 1071400000966 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1071400000967 catalytic residues [active] 1071400000968 dimer interface [polypeptide binding]; other site 1071400000969 FtsX-like permease family; Region: FtsX; pfam02687 1071400000970 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1071400000971 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1071400000972 FtsX-like permease family; Region: FtsX; pfam02687 1071400000973 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1071400000974 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1071400000975 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1071400000976 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1071400000977 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1071400000978 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1071400000979 FtsX-like permease family; Region: FtsX; pfam02687 1071400000980 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1071400000981 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1071400000982 Walker A/P-loop; other site 1071400000983 ATP binding site [chemical binding]; other site 1071400000984 Q-loop/lid; other site 1071400000985 ABC transporter signature motif; other site 1071400000986 Walker B; other site 1071400000987 D-loop; other site 1071400000988 H-loop/switch region; other site 1071400000989 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1071400000990 CoenzymeA binding site [chemical binding]; other site 1071400000991 subunit interaction site [polypeptide binding]; other site 1071400000992 PHB binding site; other site 1071400000993 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1071400000994 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1071400000995 substrate binding site [chemical binding]; other site 1071400000996 oxyanion hole (OAH) forming residues; other site 1071400000997 trimer interface [polypeptide binding]; other site 1071400000998 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1071400000999 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1071400001000 acyl-activating enzyme (AAE) consensus motif; other site 1071400001001 putative AMP binding site [chemical binding]; other site 1071400001002 putative active site [active] 1071400001003 putative CoA binding site [chemical binding]; other site 1071400001004 putrescine carbamoyltransferase; Provisional; Region: PRK02255 1071400001005 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1071400001006 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1071400001007 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1071400001008 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1071400001009 agmatine deiminase; Provisional; Region: PRK13551 1071400001010 agmatine deiminase; Region: agmatine_aguA; TIGR03380 1071400001011 carbamate kinase; Reviewed; Region: PRK12686 1071400001012 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1071400001013 putative substrate binding site [chemical binding]; other site 1071400001014 nucleotide binding site [chemical binding]; other site 1071400001015 nucleotide binding site [chemical binding]; other site 1071400001016 homodimer interface [polypeptide binding]; other site 1071400001017 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1071400001018 agmatine deiminase; Region: agmatine_aguA; TIGR03380 1071400001019 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1071400001020 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1071400001021 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1071400001022 putative active site [active] 1071400001023 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1071400001024 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1071400001025 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1071400001026 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1071400001027 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1071400001028 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1071400001029 active site 1071400001030 catalytic tetrad [active] 1071400001031 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1071400001032 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1071400001033 HD domain; Region: HD; pfam01966 1071400001034 polyphosphate kinase; Provisional; Region: PRK05443 1071400001035 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1071400001036 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1071400001037 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1071400001038 putative domain interface [polypeptide binding]; other site 1071400001039 putative active site [active] 1071400001040 catalytic site [active] 1071400001041 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1071400001042 putative domain interface [polypeptide binding]; other site 1071400001043 putative active site [active] 1071400001044 catalytic site [active] 1071400001045 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1071400001046 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1071400001047 VanZ like family; Region: VanZ; pfam04892 1071400001048 RDD family; Region: RDD; pfam06271 1071400001049 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1071400001050 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1071400001051 putative active site [active] 1071400001052 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1071400001053 ArsC family; Region: ArsC; pfam03960 1071400001054 putative catalytic residues [active] 1071400001055 thiol/disulfide switch; other site 1071400001056 transaminase; Validated; Region: PRK07324 1071400001057 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1071400001058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1071400001059 homodimer interface [polypeptide binding]; other site 1071400001060 catalytic residue [active] 1071400001061 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1071400001062 FAD binding site [chemical binding]; other site 1071400001063 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1071400001064 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1071400001065 THF binding site; other site 1071400001066 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1071400001067 substrate binding site [chemical binding]; other site 1071400001068 THF binding site; other site 1071400001069 zinc-binding site [ion binding]; other site 1071400001070 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1071400001071 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1071400001072 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1071400001073 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1071400001074 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1071400001075 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1071400001076 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1071400001077 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1071400001078 Walker A/P-loop; other site 1071400001079 ATP binding site [chemical binding]; other site 1071400001080 Q-loop/lid; other site 1071400001081 ABC transporter signature motif; other site 1071400001082 Walker B; other site 1071400001083 D-loop; other site 1071400001084 H-loop/switch region; other site 1071400001085 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1071400001086 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1071400001087 Na binding site [ion binding]; other site 1071400001088 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1071400001089 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1071400001090 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1071400001091 Cobalt transport protein; Region: CbiQ; cl00463 1071400001092 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1071400001093 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1071400001094 Walker A/P-loop; other site 1071400001095 ATP binding site [chemical binding]; other site 1071400001096 Q-loop/lid; other site 1071400001097 ABC transporter signature motif; other site 1071400001098 Walker B; other site 1071400001099 D-loop; other site 1071400001100 H-loop/switch region; other site 1071400001101 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1071400001102 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1071400001103 Walker A/P-loop; other site 1071400001104 ATP binding site [chemical binding]; other site 1071400001105 Q-loop/lid; other site 1071400001106 ABC transporter signature motif; other site 1071400001107 Walker B; other site 1071400001108 D-loop; other site 1071400001109 H-loop/switch region; other site 1071400001110 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 1071400001111 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1071400001112 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1071400001113 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1071400001114 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1071400001115 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1071400001116 Ligand binding site [chemical binding]; other site 1071400001117 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1071400001118 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1071400001119 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1071400001120 active site 1071400001121 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1071400001122 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1071400001123 non-specific DNA binding site [nucleotide binding]; other site 1071400001124 salt bridge; other site 1071400001125 sequence-specific DNA binding site [nucleotide binding]; other site 1071400001126 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1071400001127 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1071400001128 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1071400001129 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1071400001130 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1071400001131 MarR family; Region: MarR; pfam01047 1071400001132 manganese transport protein MntH; Reviewed; Region: PRK00701 1071400001133 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1071400001134 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1071400001135 Ligand Binding Site [chemical binding]; other site 1071400001136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400001137 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400001138 putative substrate translocation pore; other site 1071400001139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400001140 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1071400001141 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1071400001142 NAD(P) binding site [chemical binding]; other site 1071400001143 catalytic residues [active] 1071400001144 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1071400001145 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1071400001146 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1071400001147 putative active site [active] 1071400001148 nucleotide binding site [chemical binding]; other site 1071400001149 nudix motif; other site 1071400001150 putative metal binding site [ion binding]; other site 1071400001151 Predicted transcriptional regulators [Transcription]; Region: COG1733 1071400001152 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1071400001153 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1071400001154 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1071400001155 proposed catalytic triad [active] 1071400001156 conserved cys residue [active] 1071400001157 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1071400001158 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1071400001159 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1071400001160 NAD(P) binding site [chemical binding]; other site 1071400001161 putative active site [active] 1071400001162 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1071400001163 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1071400001164 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1071400001165 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1071400001166 metal-binding site [ion binding] 1071400001167 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1071400001168 Ferritin-like domain; Region: Ferritin; pfam00210 1071400001169 dinuclear metal binding motif [ion binding]; other site 1071400001170 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1071400001171 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1071400001172 active site 1071400001173 catalytic tetrad [active] 1071400001174 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1071400001175 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1071400001176 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1071400001177 NAD binding site [chemical binding]; other site 1071400001178 ATP-grasp domain; Region: ATP-grasp; pfam02222 1071400001179 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1071400001180 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1071400001181 ATP binding site [chemical binding]; other site 1071400001182 active site 1071400001183 substrate binding site [chemical binding]; other site 1071400001184 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 1071400001185 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1071400001186 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1071400001187 putative active site [active] 1071400001188 catalytic triad [active] 1071400001189 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1071400001190 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1071400001191 dimerization interface [polypeptide binding]; other site 1071400001192 ATP binding site [chemical binding]; other site 1071400001193 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1071400001194 dimerization interface [polypeptide binding]; other site 1071400001195 ATP binding site [chemical binding]; other site 1071400001196 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1071400001197 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1071400001198 active site 1071400001199 tetramer interface [polypeptide binding]; other site 1071400001200 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1071400001201 active site 1071400001202 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1071400001203 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1071400001204 dimerization interface [polypeptide binding]; other site 1071400001205 putative ATP binding site [chemical binding]; other site 1071400001206 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1071400001207 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1071400001208 active site 1071400001209 substrate binding site [chemical binding]; other site 1071400001210 cosubstrate binding site; other site 1071400001211 catalytic site [active] 1071400001212 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1071400001213 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1071400001214 purine monophosphate binding site [chemical binding]; other site 1071400001215 dimer interface [polypeptide binding]; other site 1071400001216 putative catalytic residues [active] 1071400001217 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1071400001218 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1071400001219 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1071400001220 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1071400001221 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1071400001222 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1071400001223 hypothetical protein; Validated; Region: PRK02101 1071400001224 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1071400001225 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1071400001226 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1071400001227 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1071400001228 active site 1071400001229 motif I; other site 1071400001230 motif II; other site 1071400001231 benzoate transport; Region: 2A0115; TIGR00895 1071400001232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400001233 PemK-like protein; Region: PemK; pfam02452 1071400001234 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1071400001235 active site 1071400001236 dimer interface [polypeptide binding]; other site 1071400001237 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1071400001238 active site 1071400001239 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1071400001240 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 1071400001241 active site 1071400001242 FMN binding site [chemical binding]; other site 1071400001243 substrate binding site [chemical binding]; other site 1071400001244 catalytic residues [active] 1071400001245 homodimer interface [polypeptide binding]; other site 1071400001246 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1071400001247 Walker A/P-loop; other site 1071400001248 ATP binding site [chemical binding]; other site 1071400001249 Q-loop/lid; other site 1071400001250 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1071400001251 ABC transporter signature motif; other site 1071400001252 Walker B; other site 1071400001253 D-loop; other site 1071400001254 H-loop/switch region; other site 1071400001255 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1071400001256 AAA domain; Region: AAA_21; pfam13304 1071400001257 Walker A/P-loop; other site 1071400001258 ATP binding site [chemical binding]; other site 1071400001259 Q-loop/lid; other site 1071400001260 ABC transporter signature motif; other site 1071400001261 Walker B; other site 1071400001262 D-loop; other site 1071400001263 H-loop/switch region; other site 1071400001264 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1071400001265 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1071400001266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400001267 putative substrate translocation pore; other site 1071400001268 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1071400001269 xylose isomerase; Provisional; Region: PRK05474 1071400001270 xylose isomerase; Region: xylose_isom_A; TIGR02630 1071400001271 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1071400001272 N- and C-terminal domain interface [polypeptide binding]; other site 1071400001273 D-xylulose kinase; Region: XylB; TIGR01312 1071400001274 active site 1071400001275 MgATP binding site [chemical binding]; other site 1071400001276 catalytic site [active] 1071400001277 metal binding site [ion binding]; metal-binding site 1071400001278 xylulose binding site [chemical binding]; other site 1071400001279 homodimer interface [polypeptide binding]; other site 1071400001280 TIGR03987 family protein; Region: TIGR03987 1071400001281 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1071400001282 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1071400001283 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1071400001284 putative DNA binding site [nucleotide binding]; other site 1071400001285 putative Zn2+ binding site [ion binding]; other site 1071400001286 AsnC family; Region: AsnC_trans_reg; pfam01037 1071400001287 drug efflux system protein MdtG; Provisional; Region: PRK09874 1071400001288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400001289 putative substrate translocation pore; other site 1071400001290 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1071400001291 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1071400001292 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1071400001293 active site 1071400001294 catalytic tetrad [active] 1071400001295 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 1071400001296 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1071400001297 putative NAD(P) binding site [chemical binding]; other site 1071400001298 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1071400001299 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1071400001300 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1071400001301 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 1071400001302 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1071400001303 Walker A/P-loop; other site 1071400001304 ATP binding site [chemical binding]; other site 1071400001305 Q-loop/lid; other site 1071400001306 ABC transporter signature motif; other site 1071400001307 Walker B; other site 1071400001308 D-loop; other site 1071400001309 H-loop/switch region; other site 1071400001310 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1071400001311 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1071400001312 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1071400001313 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1071400001314 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1071400001315 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 1071400001316 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696 1071400001317 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1071400001318 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696 1071400001319 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1071400001320 Protein of unknown function (DUF1168); Region: DUF1168; pfam06658 1071400001321 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1071400001322 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1071400001323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1071400001324 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1071400001325 active site 1071400001326 Fe-S cluster binding site [ion binding]; other site 1071400001327 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 1071400001328 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1071400001329 lipoyl attachment site [posttranslational modification]; other site 1071400001330 Homeodomain-like domain; Region: HTH_23; cl17451 1071400001331 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1071400001332 Helix-turn-helix domain; Region: HTH_28; pfam13518 1071400001333 HTH-like domain; Region: HTH_21; pfam13276 1071400001334 Integrase core domain; Region: rve; pfam00665 1071400001335 Integrase core domain; Region: rve_3; cl15866 1071400001336 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1071400001337 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1071400001338 tetramer interface [polypeptide binding]; other site 1071400001339 active site 1071400001340 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1071400001341 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1071400001342 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1071400001343 lipoyl attachment site [posttranslational modification]; other site 1071400001344 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1071400001345 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1071400001346 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1071400001347 active site 1071400001348 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1071400001349 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1071400001350 catalytic tetrad [active] 1071400001351 Predicted membrane protein [Function unknown]; Region: COG3428 1071400001352 Bacterial PH domain; Region: DUF304; pfam03703 1071400001353 Bacterial PH domain; Region: DUF304; pfam03703 1071400001354 Bacterial PH domain; Region: DUF304; pfam03703 1071400001355 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1071400001356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400001357 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400001358 putative substrate translocation pore; other site 1071400001359 acetoin reductase; Validated; Region: PRK08643 1071400001360 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1071400001361 NAD binding site [chemical binding]; other site 1071400001362 homotetramer interface [polypeptide binding]; other site 1071400001363 homodimer interface [polypeptide binding]; other site 1071400001364 active site 1071400001365 substrate binding site [chemical binding]; other site 1071400001366 Integral membrane protein DUF95; Region: DUF95; cl00572 1071400001367 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1071400001368 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1071400001369 active site 1071400001370 catalytic tetrad [active] 1071400001371 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1071400001372 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1071400001373 Walker A/P-loop; other site 1071400001374 ATP binding site [chemical binding]; other site 1071400001375 Q-loop/lid; other site 1071400001376 ABC transporter signature motif; other site 1071400001377 Walker B; other site 1071400001378 D-loop; other site 1071400001379 H-loop/switch region; other site 1071400001380 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1071400001381 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1071400001382 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1071400001383 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1071400001384 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1071400001385 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1071400001386 3D domain; Region: 3D; cl01439 1071400001387 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1071400001388 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1071400001389 ligand binding site [chemical binding]; other site 1071400001390 flexible hinge region; other site 1071400001391 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1071400001392 non-specific DNA interactions [nucleotide binding]; other site 1071400001393 DNA binding site [nucleotide binding] 1071400001394 sequence specific DNA binding site [nucleotide binding]; other site 1071400001395 putative cAMP binding site [chemical binding]; other site 1071400001396 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 1071400001397 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1071400001398 putative N- and C-terminal domain interface [polypeptide binding]; other site 1071400001399 putative active site [active] 1071400001400 MgATP binding site [chemical binding]; other site 1071400001401 catalytic site [active] 1071400001402 metal binding site [ion binding]; metal-binding site 1071400001403 putative carbohydrate binding site [chemical binding]; other site 1071400001404 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1071400001405 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1071400001406 intersubunit interface [polypeptide binding]; other site 1071400001407 active site 1071400001408 Zn2+ binding site [ion binding]; other site 1071400001409 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1071400001410 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1071400001411 active site 1071400001412 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1071400001413 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1071400001414 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1071400001415 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1071400001416 active site 1071400001417 metal binding site [ion binding]; metal-binding site 1071400001418 hexamer interface [polypeptide binding]; other site 1071400001419 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1071400001420 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1071400001421 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1071400001422 Coenzyme A binding pocket [chemical binding]; other site 1071400001423 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 1071400001424 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1071400001425 active site 1071400001426 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1071400001427 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1071400001428 ABC transporter; Region: ABC_tran_2; pfam12848 1071400001429 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1071400001430 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1071400001431 catalytic triad [active] 1071400001432 catalytic triad [active] 1071400001433 oxyanion hole [active] 1071400001434 Serine hydrolase; Region: Ser_hydrolase; cl17834 1071400001435 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1071400001436 Putative transcription activator [Transcription]; Region: TenA; COG0819 1071400001437 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 1071400001438 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1071400001439 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1071400001440 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1071400001441 active site 1071400001442 catalytic tetrad [active] 1071400001443 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1071400001444 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1071400001445 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1071400001446 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1071400001447 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1071400001448 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1071400001449 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1071400001450 motif II; other site 1071400001451 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1071400001452 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1071400001453 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1071400001454 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1071400001455 xanthine permease; Region: pbuX; TIGR03173 1071400001456 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1071400001457 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1071400001458 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1071400001459 dimerization interface [polypeptide binding]; other site 1071400001460 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1071400001461 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1071400001462 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1071400001463 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1071400001464 Arginine repressor [Transcription]; Region: ArgR; COG1438 1071400001465 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1071400001466 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1071400001467 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1071400001468 arginine deiminase; Provisional; Region: PRK01388 1071400001469 ornithine carbamoyltransferase; Validated; Region: PRK02102 1071400001470 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1071400001471 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1071400001472 carbamate kinase; Reviewed; Region: PRK12686 1071400001473 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1071400001474 putative substrate binding site [chemical binding]; other site 1071400001475 nucleotide binding site [chemical binding]; other site 1071400001476 nucleotide binding site [chemical binding]; other site 1071400001477 homodimer interface [polypeptide binding]; other site 1071400001478 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1071400001479 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1071400001480 ligand binding site [chemical binding]; other site 1071400001481 flexible hinge region; other site 1071400001482 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1071400001483 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 1071400001484 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1071400001485 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1071400001486 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1071400001487 motif II; other site 1071400001488 DsrE/DsrF-like family; Region: DrsE; cl00672 1071400001489 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1071400001490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1071400001491 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1071400001492 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1071400001493 DNA binding site [nucleotide binding] 1071400001494 active site 1071400001495 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1071400001496 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1071400001497 non-specific DNA binding site [nucleotide binding]; other site 1071400001498 salt bridge; other site 1071400001499 sequence-specific DNA binding site [nucleotide binding]; other site 1071400001500 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1071400001501 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1071400001502 phosphodiesterase; Provisional; Region: PRK12704 1071400001503 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1071400001504 Zn2+ binding site [ion binding]; other site 1071400001505 Mg2+ binding site [ion binding]; other site 1071400001506 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1071400001507 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1071400001508 active site 1071400001509 metal binding site [ion binding]; metal-binding site 1071400001510 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1071400001511 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1071400001512 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1071400001513 putative catalytic residues [active] 1071400001514 thiol/disulfide switch; other site 1071400001515 ArsC family; Region: ArsC; pfam03960 1071400001516 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1071400001517 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1071400001518 active site 1071400001519 motif I; other site 1071400001520 motif II; other site 1071400001521 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1071400001522 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1071400001523 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349 1071400001524 active site 1071400001525 active site 1071400001526 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1071400001527 active site 1071400001528 Protease prsW family; Region: PrsW-protease; cl15823 1071400001529 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1071400001530 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1071400001531 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1071400001532 Walker A/P-loop; other site 1071400001533 ATP binding site [chemical binding]; other site 1071400001534 Q-loop/lid; other site 1071400001535 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1071400001536 ABC transporter signature motif; other site 1071400001537 Walker B; other site 1071400001538 D-loop; other site 1071400001539 H-loop/switch region; other site 1071400001540 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1071400001541 AAA domain; Region: AAA_21; pfam13304 1071400001542 Walker A/P-loop; other site 1071400001543 ATP binding site [chemical binding]; other site 1071400001544 Q-loop/lid; other site 1071400001545 ABC transporter signature motif; other site 1071400001546 Walker B; other site 1071400001547 D-loop; other site 1071400001548 H-loop/switch region; other site 1071400001549 Ion channel; Region: Ion_trans_2; pfam07885 1071400001550 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1071400001551 Sulfatase; Region: Sulfatase; pfam00884 1071400001552 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1071400001553 catalytic core [active] 1071400001554 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1071400001555 Coenzyme A binding pocket [chemical binding]; other site 1071400001556 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1071400001557 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1071400001558 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1071400001559 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1071400001560 NlpC/P60 family; Region: NLPC_P60; pfam00877 1071400001561 Transport protein; Region: actII; TIGR00833 1071400001562 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1071400001563 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1071400001564 active site 1071400001565 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1071400001566 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1071400001567 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1071400001568 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1071400001569 catalytic residues [active] 1071400001570 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1071400001571 Coenzyme A binding pocket [chemical binding]; other site 1071400001572 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1071400001573 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1071400001574 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1071400001575 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1071400001576 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1071400001577 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1071400001578 active site 1071400001579 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1071400001580 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1071400001581 GDP-binding site [chemical binding]; other site 1071400001582 ACT binding site; other site 1071400001583 IMP binding site; other site 1071400001584 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1071400001585 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1071400001586 tetramer interface [polypeptide binding]; other site 1071400001587 active site 1071400001588 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1071400001589 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1071400001590 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1071400001591 putative NAD(P) binding site [chemical binding]; other site 1071400001592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 1071400001593 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1071400001594 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1071400001595 Predicted membrane protein [Function unknown]; Region: COG2364 1071400001596 glycerol kinase; Provisional; Region: glpK; PRK00047 1071400001597 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1071400001598 N- and C-terminal domain interface [polypeptide binding]; other site 1071400001599 active site 1071400001600 MgATP binding site [chemical binding]; other site 1071400001601 catalytic site [active] 1071400001602 metal binding site [ion binding]; metal-binding site 1071400001603 glycerol binding site [chemical binding]; other site 1071400001604 homotetramer interface [polypeptide binding]; other site 1071400001605 homodimer interface [polypeptide binding]; other site 1071400001606 FBP binding site [chemical binding]; other site 1071400001607 protein IIAGlc interface [polypeptide binding]; other site 1071400001608 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1071400001609 TRAM domain; Region: TRAM; pfam01938 1071400001610 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1071400001611 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1071400001612 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1071400001613 active site 1071400001614 catalytic tetrad [active] 1071400001615 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1071400001616 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1071400001617 Coenzyme A binding pocket [chemical binding]; other site 1071400001618 short chain dehydrogenase; Validated; Region: PRK06182 1071400001619 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1071400001620 NADP binding site [chemical binding]; other site 1071400001621 active site 1071400001622 steroid binding site; other site 1071400001623 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1071400001624 substrate binding site [chemical binding]; other site 1071400001625 multimerization interface [polypeptide binding]; other site 1071400001626 ATP binding site [chemical binding]; other site 1071400001627 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1071400001628 substrate binding site [chemical binding]; other site 1071400001629 dimer interface [polypeptide binding]; other site 1071400001630 ATP binding site [chemical binding]; other site 1071400001631 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1071400001632 thiamine phosphate binding site [chemical binding]; other site 1071400001633 active site 1071400001634 pyrophosphate binding site [ion binding]; other site 1071400001635 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1071400001636 active site 1071400001637 Protein of unknown function (DUF1516); Region: DUF1516; pfam07457 1071400001638 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 1071400001639 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1071400001640 active site 1071400001641 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 1071400001642 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1071400001643 non-specific DNA binding site [nucleotide binding]; other site 1071400001644 salt bridge; other site 1071400001645 sequence-specific DNA binding site [nucleotide binding]; other site 1071400001646 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1071400001647 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1071400001648 Walker A/P-loop; other site 1071400001649 ATP binding site [chemical binding]; other site 1071400001650 Q-loop/lid; other site 1071400001651 ABC transporter signature motif; other site 1071400001652 Walker B; other site 1071400001653 D-loop; other site 1071400001654 H-loop/switch region; other site 1071400001655 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1071400001656 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1071400001657 FtsX-like permease family; Region: FtsX; pfam02687 1071400001658 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1071400001659 EDD domain protein, DegV family; Region: DegV; TIGR00762 1071400001660 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1071400001661 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1071400001662 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1071400001663 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1071400001664 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1071400001665 RelB antitoxin; Region: RelB; cl01171 1071400001666 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 1071400001667 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1071400001668 NlpC/P60 family; Region: NLPC_P60; pfam00877 1071400001669 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1071400001670 dimerization domain swap beta strand [polypeptide binding]; other site 1071400001671 regulatory protein interface [polypeptide binding]; other site 1071400001672 active site 1071400001673 regulatory phosphorylation site [posttranslational modification]; other site 1071400001674 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1071400001675 peptidase domain interface [polypeptide binding]; other site 1071400001676 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 1071400001677 active site 1071400001678 catalytic triad [active] 1071400001679 calcium binding site [ion binding]; other site 1071400001680 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1071400001681 putative deacylase active site [active] 1071400001682 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1071400001683 Homeodomain-like domain; Region: HTH_23; pfam13384 1071400001684 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 1071400001685 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1071400001686 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1071400001687 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1071400001688 active site 1071400001689 catalytic triad [active] 1071400001690 oxyanion hole [active] 1071400001691 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 1071400001692 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 1071400001693 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1071400001694 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1071400001695 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1071400001696 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1071400001697 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1071400001698 active site 1071400001699 tetramer interface [polypeptide binding]; other site 1071400001700 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1071400001701 peptidase T; Region: peptidase-T; TIGR01882 1071400001702 metal binding site [ion binding]; metal-binding site 1071400001703 dimer interface [polypeptide binding]; other site 1071400001704 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1071400001705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1071400001706 S-adenosylmethionine binding site [chemical binding]; other site 1071400001707 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1071400001708 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1071400001709 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1071400001710 Magnesium ion binding site [ion binding]; other site 1071400001711 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1071400001712 ParB-like nuclease domain; Region: ParB; smart00470 1071400001713 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1071400001714 GTP-binding protein YchF; Reviewed; Region: PRK09601 1071400001715 YchF GTPase; Region: YchF; cd01900 1071400001716 G1 box; other site 1071400001717 GTP/Mg2+ binding site [chemical binding]; other site 1071400001718 Switch I region; other site 1071400001719 G2 box; other site 1071400001720 Switch II region; other site 1071400001721 G3 box; other site 1071400001722 G4 box; other site 1071400001723 G5 box; other site 1071400001724 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1071400001725 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 1071400001726 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1071400001727 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 1071400001728 active site 1071400001729 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1071400001730 nudix motif; other site 1071400001731 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1071400001732 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1071400001733 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1071400001734 active site 1071400001735 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1071400001736 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1071400001737 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1071400001738 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1071400001739 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1071400001740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1071400001741 active site 1071400001742 phosphorylation site [posttranslational modification] 1071400001743 intermolecular recognition site; other site 1071400001744 dimerization interface [polypeptide binding]; other site 1071400001745 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1071400001746 DNA binding site [nucleotide binding] 1071400001747 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1071400001748 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1071400001749 dimer interface [polypeptide binding]; other site 1071400001750 phosphorylation site [posttranslational modification] 1071400001751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1071400001752 ATP binding site [chemical binding]; other site 1071400001753 Mg2+ binding site [ion binding]; other site 1071400001754 G-X-G motif; other site 1071400001755 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1071400001756 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1071400001757 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1071400001758 AzlC protein; Region: AzlC; pfam03591 1071400001759 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1071400001760 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1071400001761 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1071400001762 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1071400001763 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1071400001764 catalytic core [active] 1071400001765 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1071400001766 inner membrane transporter YjeM; Provisional; Region: PRK15238 1071400001767 maltose O-acetyltransferase; Provisional; Region: PRK10092 1071400001768 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1071400001769 active site 1071400001770 substrate binding site [chemical binding]; other site 1071400001771 trimer interface [polypeptide binding]; other site 1071400001772 CoA binding site [chemical binding]; other site 1071400001773 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 1071400001774 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1071400001775 minor groove reading motif; other site 1071400001776 helix-hairpin-helix signature motif; other site 1071400001777 substrate binding pocket [chemical binding]; other site 1071400001778 active site 1071400001779 Sugar transport protein; Region: Sugar_transport; pfam06800 1071400001780 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1071400001781 DNA-binding site [nucleotide binding]; DNA binding site 1071400001782 RNA-binding motif; other site 1071400001783 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 1071400001784 xanthine permease; Region: pbuX; TIGR03173 1071400001785 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1071400001786 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1071400001787 manganese transport protein MntH; Reviewed; Region: PRK00701 1071400001788 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1071400001789 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1071400001790 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1071400001791 Cl binding site [ion binding]; other site 1071400001792 oligomer interface [polypeptide binding]; other site 1071400001793 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1071400001794 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1071400001795 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1071400001796 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1071400001797 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1071400001798 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400001799 putative substrate translocation pore; other site 1071400001800 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400001801 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1071400001802 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1071400001803 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1071400001804 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1071400001805 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 1071400001806 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1071400001807 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1071400001808 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1071400001809 CAAX protease self-immunity; Region: Abi; pfam02517 1071400001810 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1071400001811 active site 1071400001812 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1071400001813 Coenzyme A binding pocket [chemical binding]; other site 1071400001814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400001815 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400001816 putative substrate translocation pore; other site 1071400001817 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1071400001818 nudix motif; other site 1071400001819 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1071400001820 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 1071400001821 putative ligand binding site [chemical binding]; other site 1071400001822 putative NAD binding site [chemical binding]; other site 1071400001823 catalytic site [active] 1071400001824 Fic/DOC family; Region: Fic; pfam02661 1071400001825 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1071400001826 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1071400001827 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1071400001828 homodimer interface [polypeptide binding]; other site 1071400001829 catalytic residue [active] 1071400001830 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 1071400001831 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1071400001832 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 1071400001833 NAD(P) binding site [chemical binding]; other site 1071400001834 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1071400001835 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1071400001836 NAD(P) binding site [chemical binding]; other site 1071400001837 active site 1071400001838 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1071400001839 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1071400001840 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1071400001841 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1071400001842 DNA-binding site [nucleotide binding]; DNA binding site 1071400001843 FCD domain; Region: FCD; pfam07729 1071400001844 mannonate dehydratase; Provisional; Region: PRK03906 1071400001845 mannonate dehydratase; Region: uxuA; TIGR00695 1071400001846 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1071400001847 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1071400001848 substrate binding site [chemical binding]; other site 1071400001849 ATP binding site [chemical binding]; other site 1071400001850 Protein of unknown function (DUF975); Region: DUF975; cl10504 1071400001851 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1071400001852 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1071400001853 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1071400001854 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1071400001855 histidinol dehydrogenase; Region: hisD; TIGR00069 1071400001856 NAD binding site [chemical binding]; other site 1071400001857 dimerization interface [polypeptide binding]; other site 1071400001858 product binding site; other site 1071400001859 substrate binding site [chemical binding]; other site 1071400001860 zinc binding site [ion binding]; other site 1071400001861 catalytic residues [active] 1071400001862 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1071400001863 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1071400001864 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1071400001865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400001866 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400001867 putative substrate translocation pore; other site 1071400001868 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1071400001869 amphipathic channel; other site 1071400001870 Asn-Pro-Ala signature motifs; other site 1071400001871 Protein of unknown function (DUF975); Region: DUF975; cl10504 1071400001872 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1071400001873 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1071400001874 homodimer interface [polypeptide binding]; other site 1071400001875 substrate-cofactor binding pocket; other site 1071400001876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1071400001877 catalytic residue [active] 1071400001878 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1071400001879 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1071400001880 dimer interface [polypeptide binding]; other site 1071400001881 active site 1071400001882 metal binding site [ion binding]; metal-binding site 1071400001883 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1071400001884 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1071400001885 NAD binding site [chemical binding]; other site 1071400001886 substrate binding site [chemical binding]; other site 1071400001887 homodimer interface [polypeptide binding]; other site 1071400001888 active site 1071400001889 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1071400001890 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1071400001891 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1071400001892 DNA binding residues [nucleotide binding] 1071400001893 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1071400001894 putative dimer interface [polypeptide binding]; other site 1071400001895 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1071400001896 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1071400001897 active site 1071400001898 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1071400001899 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1071400001900 active site 1071400001901 HIGH motif; other site 1071400001902 dimer interface [polypeptide binding]; other site 1071400001903 KMSKS motif; other site 1071400001904 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1071400001905 RNA binding surface [nucleotide binding]; other site 1071400001906 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1071400001907 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1071400001908 ArsC family; Region: ArsC; pfam03960 1071400001909 putative catalytic residues [active] 1071400001910 thiol/disulfide switch; other site 1071400001911 adaptor protein; Provisional; Region: PRK02315 1071400001912 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1071400001913 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1071400001914 Ligand binding site; other site 1071400001915 Putative Catalytic site; other site 1071400001916 DXD motif; other site 1071400001917 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1071400001918 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1071400001919 GtrA-like protein; Region: GtrA; pfam04138 1071400001920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1071400001921 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1071400001922 active site 1071400001923 phosphorylation site [posttranslational modification] 1071400001924 intermolecular recognition site; other site 1071400001925 dimerization interface [polypeptide binding]; other site 1071400001926 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1071400001927 DNA binding site [nucleotide binding] 1071400001928 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1071400001929 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1071400001930 dimer interface [polypeptide binding]; other site 1071400001931 phosphorylation site [posttranslational modification] 1071400001932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1071400001933 ATP binding site [chemical binding]; other site 1071400001934 Mg2+ binding site [ion binding]; other site 1071400001935 G-X-G motif; other site 1071400001936 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1071400001937 Competence protein CoiA-like family; Region: CoiA; cl11541 1071400001938 oligoendopeptidase F; Region: pepF; TIGR00181 1071400001939 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1071400001940 active site 1071400001941 Zn binding site [ion binding]; other site 1071400001942 Thioredoxin; Region: Thioredoxin_5; pfam13743 1071400001943 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1071400001944 synthetase active site [active] 1071400001945 NTP binding site [chemical binding]; other site 1071400001946 metal binding site [ion binding]; metal-binding site 1071400001947 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1071400001948 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1071400001949 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1071400001950 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1071400001951 active site 1071400001952 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1071400001953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1071400001954 S-adenosylmethionine binding site [chemical binding]; other site 1071400001955 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1071400001956 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1071400001957 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1071400001958 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1071400001959 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 1071400001960 cell division protein MraZ; Reviewed; Region: PRK00326 1071400001961 MraZ protein; Region: MraZ; pfam02381 1071400001962 MraZ protein; Region: MraZ; pfam02381 1071400001963 MraW methylase family; Region: Methyltransf_5; pfam01795 1071400001964 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1071400001965 Cell division protein FtsL; Region: FtsL; cl11433 1071400001966 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1071400001967 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1071400001968 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1071400001969 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1071400001970 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1071400001971 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1071400001972 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1071400001973 Mg++ binding site [ion binding]; other site 1071400001974 putative catalytic motif [active] 1071400001975 putative substrate binding site [chemical binding]; other site 1071400001976 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1071400001977 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1071400001978 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1071400001979 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1071400001980 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1071400001981 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1071400001982 active site 1071400001983 homodimer interface [polypeptide binding]; other site 1071400001984 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1071400001985 Cell division protein FtsQ; Region: FtsQ; pfam03799 1071400001986 cell division protein FtsA; Region: ftsA; TIGR01174 1071400001987 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1071400001988 nucleotide binding site [chemical binding]; other site 1071400001989 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 1071400001990 Cell division protein FtsA; Region: FtsA; pfam14450 1071400001991 cell division protein FtsZ; Validated; Region: PRK09330 1071400001992 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1071400001993 nucleotide binding site [chemical binding]; other site 1071400001994 SulA interaction site; other site 1071400001995 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1071400001996 YGGT family; Region: YGGT; pfam02325 1071400001997 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1071400001998 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1071400001999 RNA binding surface [nucleotide binding]; other site 1071400002000 DivIVA protein; Region: DivIVA; pfam05103 1071400002001 DivIVA domain; Region: DivI1A_domain; TIGR03544 1071400002002 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1071400002003 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1071400002004 active site 1071400002005 HIGH motif; other site 1071400002006 nucleotide binding site [chemical binding]; other site 1071400002007 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1071400002008 active site 1071400002009 KMSKS motif; other site 1071400002010 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1071400002011 tRNA binding surface [nucleotide binding]; other site 1071400002012 anticodon binding site; other site 1071400002013 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1071400002014 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1071400002015 DNA-binding site [nucleotide binding]; DNA binding site 1071400002016 RNA-binding motif; other site 1071400002017 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1071400002018 dimer interface [polypeptide binding]; other site 1071400002019 ADP-ribose binding site [chemical binding]; other site 1071400002020 active site 1071400002021 nudix motif; other site 1071400002022 metal binding site [ion binding]; metal-binding site 1071400002023 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1071400002024 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1071400002025 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1071400002026 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1071400002027 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1071400002028 catalytic residue [active] 1071400002029 Putative amino acid metabolism; Region: DUF1831; pfam08866 1071400002030 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1071400002031 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1071400002032 homodimer interface [polypeptide binding]; other site 1071400002033 substrate-cofactor binding pocket; other site 1071400002034 catalytic residue [active] 1071400002035 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1071400002036 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1071400002037 homodimer interface [polypeptide binding]; other site 1071400002038 substrate-cofactor binding pocket; other site 1071400002039 catalytic residue [active] 1071400002040 histidinol-phosphatase; Reviewed; Region: PRK08123 1071400002041 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1071400002042 active site 1071400002043 dimer interface [polypeptide binding]; other site 1071400002044 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 1071400002045 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1071400002046 dimer interface [polypeptide binding]; other site 1071400002047 motif 1; other site 1071400002048 active site 1071400002049 motif 2; other site 1071400002050 motif 3; other site 1071400002051 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1071400002052 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1071400002053 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1071400002054 putative active site pocket [active] 1071400002055 4-fold oligomerization interface [polypeptide binding]; other site 1071400002056 metal binding residues [ion binding]; metal-binding site 1071400002057 3-fold/trimer interface [polypeptide binding]; other site 1071400002058 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1071400002059 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1071400002060 putative active site [active] 1071400002061 oxyanion strand; other site 1071400002062 catalytic triad [active] 1071400002063 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1071400002064 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1071400002065 catalytic residues [active] 1071400002066 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1071400002067 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1071400002068 substrate binding site [chemical binding]; other site 1071400002069 glutamase interaction surface [polypeptide binding]; other site 1071400002070 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1071400002071 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1071400002072 metal binding site [ion binding]; metal-binding site 1071400002073 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1071400002074 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1071400002075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1071400002076 homodimer interface [polypeptide binding]; other site 1071400002077 catalytic residue [active] 1071400002078 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1071400002079 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1071400002080 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1071400002081 catalytic core [active] 1071400002082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1071400002083 binding surface 1071400002084 TPR motif; other site 1071400002085 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1071400002086 binding surface 1071400002087 TPR motif; other site 1071400002088 TPR repeat; Region: TPR_11; pfam13414 1071400002089 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1071400002090 AAA domain; Region: AAA_30; pfam13604 1071400002091 Family description; Region: UvrD_C_2; pfam13538 1071400002092 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1071400002093 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1071400002094 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1071400002095 active site 1071400002096 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1071400002097 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1071400002098 active site 1071400002099 catalytic tetrad [active] 1071400002100 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1071400002101 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1071400002102 DNA binding site [nucleotide binding] 1071400002103 domain linker motif; other site 1071400002104 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1071400002105 dimerization interface [polypeptide binding]; other site 1071400002106 ligand binding site [chemical binding]; other site 1071400002107 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1071400002108 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1071400002109 substrate binding site [chemical binding]; other site 1071400002110 dimer interface [polypeptide binding]; other site 1071400002111 ATP binding site [chemical binding]; other site 1071400002112 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1071400002113 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1071400002114 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1071400002115 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1071400002116 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1071400002117 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1071400002118 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 1071400002119 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1071400002120 non-specific DNA binding site [nucleotide binding]; other site 1071400002121 salt bridge; other site 1071400002122 sequence-specific DNA binding site [nucleotide binding]; other site 1071400002123 H+ Antiporter protein; Region: 2A0121; TIGR00900 1071400002124 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1071400002125 active site 1071400002126 catalytic residues [active] 1071400002127 metal binding site [ion binding]; metal-binding site 1071400002128 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1071400002129 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1071400002130 TPP-binding site [chemical binding]; other site 1071400002131 heterodimer interface [polypeptide binding]; other site 1071400002132 tetramer interface [polypeptide binding]; other site 1071400002133 phosphorylation loop region [posttranslational modification] 1071400002134 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1071400002135 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1071400002136 alpha subunit interface [polypeptide binding]; other site 1071400002137 TPP binding site [chemical binding]; other site 1071400002138 heterodimer interface [polypeptide binding]; other site 1071400002139 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1071400002140 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1071400002141 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1071400002142 E3 interaction surface; other site 1071400002143 lipoyl attachment site [posttranslational modification]; other site 1071400002144 e3 binding domain; Region: E3_binding; pfam02817 1071400002145 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1071400002146 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1071400002147 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1071400002148 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1071400002149 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1071400002150 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 1071400002151 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1071400002152 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1071400002153 active site 1071400002154 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1071400002155 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1071400002156 G1 box; other site 1071400002157 putative GEF interaction site [polypeptide binding]; other site 1071400002158 GTP/Mg2+ binding site [chemical binding]; other site 1071400002159 Switch I region; other site 1071400002160 G2 box; other site 1071400002161 G3 box; other site 1071400002162 Switch II region; other site 1071400002163 G4 box; other site 1071400002164 G5 box; other site 1071400002165 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1071400002166 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1071400002167 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1071400002168 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 1071400002169 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1071400002170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1071400002171 S-adenosylmethionine binding site [chemical binding]; other site 1071400002172 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1071400002173 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1071400002174 active site 1071400002175 (T/H)XGH motif; other site 1071400002176 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1071400002177 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1071400002178 protein binding site [polypeptide binding]; other site 1071400002179 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1071400002180 SLBB domain; Region: SLBB; pfam10531 1071400002181 comEA protein; Region: comE; TIGR01259 1071400002182 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1071400002183 catalytic motif [active] 1071400002184 Zn binding site [ion binding]; other site 1071400002185 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1071400002186 Competence protein; Region: Competence; pfam03772 1071400002187 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1071400002188 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1071400002189 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1071400002190 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1071400002191 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1071400002192 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1071400002193 16S/18S rRNA binding site [nucleotide binding]; other site 1071400002194 S13e-L30e interaction site [polypeptide binding]; other site 1071400002195 25S rRNA binding site [nucleotide binding]; other site 1071400002196 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1071400002197 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1071400002198 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1071400002199 elongation factor Tu; Reviewed; Region: PRK00049 1071400002200 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1071400002201 G1 box; other site 1071400002202 GEF interaction site [polypeptide binding]; other site 1071400002203 GTP/Mg2+ binding site [chemical binding]; other site 1071400002204 Switch I region; other site 1071400002205 G2 box; other site 1071400002206 G3 box; other site 1071400002207 Switch II region; other site 1071400002208 G4 box; other site 1071400002209 G5 box; other site 1071400002210 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1071400002211 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1071400002212 Antibiotic Binding Site [chemical binding]; other site 1071400002213 trigger factor; Provisional; Region: tig; PRK01490 1071400002214 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1071400002215 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1071400002216 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1071400002217 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1071400002218 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1071400002219 Walker A motif; other site 1071400002220 ATP binding site [chemical binding]; other site 1071400002221 Walker B motif; other site 1071400002222 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1071400002223 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1071400002224 G1 box; other site 1071400002225 GTP/Mg2+ binding site [chemical binding]; other site 1071400002226 Switch I region; other site 1071400002227 G2 box; other site 1071400002228 G3 box; other site 1071400002229 Switch II region; other site 1071400002230 G4 box; other site 1071400002231 G5 box; other site 1071400002232 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 1071400002233 putative metal binding site [ion binding]; other site 1071400002234 argininosuccinate synthase; Provisional; Region: PRK13820 1071400002235 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1071400002236 ANP binding site [chemical binding]; other site 1071400002237 Substrate Binding Site II [chemical binding]; other site 1071400002238 Substrate Binding Site I [chemical binding]; other site 1071400002239 argininosuccinate lyase; Provisional; Region: PRK00855 1071400002240 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1071400002241 active sites [active] 1071400002242 tetramer interface [polypeptide binding]; other site 1071400002243 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1071400002244 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1071400002245 substrate binding pocket [chemical binding]; other site 1071400002246 membrane-bound complex binding site; other site 1071400002247 hinge residues; other site 1071400002248 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1071400002249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1071400002250 dimer interface [polypeptide binding]; other site 1071400002251 conserved gate region; other site 1071400002252 putative PBP binding loops; other site 1071400002253 ABC-ATPase subunit interface; other site 1071400002254 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1071400002255 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1071400002256 Walker A/P-loop; other site 1071400002257 ATP binding site [chemical binding]; other site 1071400002258 Q-loop/lid; other site 1071400002259 ABC transporter signature motif; other site 1071400002260 Walker B; other site 1071400002261 D-loop; other site 1071400002262 H-loop/switch region; other site 1071400002263 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1071400002264 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1071400002265 GIY-YIG motif/motif A; other site 1071400002266 active site 1071400002267 catalytic site [active] 1071400002268 putative DNA binding site [nucleotide binding]; other site 1071400002269 metal binding site [ion binding]; metal-binding site 1071400002270 UvrB/uvrC motif; Region: UVR; pfam02151 1071400002271 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1071400002272 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1071400002273 DNA binding site [nucleotide binding] 1071400002274 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1071400002275 GTP1/OBG; Region: GTP1_OBG; pfam01018 1071400002276 Obg GTPase; Region: Obg; cd01898 1071400002277 G1 box; other site 1071400002278 GTP/Mg2+ binding site [chemical binding]; other site 1071400002279 Switch I region; other site 1071400002280 G2 box; other site 1071400002281 G3 box; other site 1071400002282 Switch II region; other site 1071400002283 G4 box; other site 1071400002284 G5 box; other site 1071400002285 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1071400002286 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1071400002287 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1071400002288 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1071400002289 catalytic triad [active] 1071400002290 catalytic triad [active] 1071400002291 oxyanion hole [active] 1071400002292 ribonuclease Z; Region: RNase_Z; TIGR02651 1071400002293 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1071400002294 DHH family; Region: DHH; pfam01368 1071400002295 DHHA1 domain; Region: DHHA1; pfam02272 1071400002296 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 1071400002297 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1071400002298 active site 1071400002299 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1071400002300 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1071400002301 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 1071400002302 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1071400002303 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1071400002304 Walker A/P-loop; other site 1071400002305 ATP binding site [chemical binding]; other site 1071400002306 Q-loop/lid; other site 1071400002307 ABC transporter signature motif; other site 1071400002308 Walker B; other site 1071400002309 D-loop; other site 1071400002310 H-loop/switch region; other site 1071400002311 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1071400002312 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1071400002313 substrate binding pocket [chemical binding]; other site 1071400002314 membrane-bound complex binding site; other site 1071400002315 hinge residues; other site 1071400002316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1071400002317 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1071400002318 dimer interface [polypeptide binding]; other site 1071400002319 conserved gate region; other site 1071400002320 putative PBP binding loops; other site 1071400002321 ABC-ATPase subunit interface; other site 1071400002322 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1071400002323 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1071400002324 substrate binding pocket [chemical binding]; other site 1071400002325 membrane-bound complex binding site; other site 1071400002326 hinge residues; other site 1071400002327 transaminase; Reviewed; Region: PRK08068 1071400002328 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1071400002329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1071400002330 homodimer interface [polypeptide binding]; other site 1071400002331 catalytic residue [active] 1071400002332 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1071400002333 active site 1071400002334 active site 1071400002335 DNA polymerase IV; Reviewed; Region: PRK03103 1071400002336 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1071400002337 active site 1071400002338 DNA binding site [nucleotide binding] 1071400002339 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1071400002340 maltose O-acetyltransferase; Provisional; Region: PRK10092 1071400002341 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1071400002342 active site 1071400002343 substrate binding site [chemical binding]; other site 1071400002344 trimer interface [polypeptide binding]; other site 1071400002345 CoA binding site [chemical binding]; other site 1071400002346 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1071400002347 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1071400002348 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1071400002349 Coenzyme A binding pocket [chemical binding]; other site 1071400002350 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1071400002351 putative deacylase active site [active] 1071400002352 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1071400002353 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1071400002354 MMPL family; Region: MMPL; pfam03176 1071400002355 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1071400002356 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1071400002357 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1071400002358 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 1071400002359 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1071400002360 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1071400002361 amidase catalytic site [active] 1071400002362 Zn binding residues [ion binding]; other site 1071400002363 substrate binding site [chemical binding]; other site 1071400002364 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1071400002365 Aspartase; Region: Aspartase; cd01357 1071400002366 active sites [active] 1071400002367 tetramer interface [polypeptide binding]; other site 1071400002368 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1071400002369 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1071400002370 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1071400002371 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1071400002372 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1071400002373 motif II; other site 1071400002374 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1071400002375 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1071400002376 MarR family; Region: MarR; pfam01047 1071400002377 MarR family; Region: MarR_2; cl17246 1071400002378 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1071400002379 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1071400002380 Coenzyme A binding pocket [chemical binding]; other site 1071400002381 B3/4 domain; Region: B3_4; smart00873 1071400002382 B3/4 domain; Region: B3_4; pfam03483 1071400002383 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1071400002384 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 1071400002385 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1071400002386 trimer interface [polypeptide binding]; other site 1071400002387 active site 1071400002388 substrate binding site [chemical binding]; other site 1071400002389 CoA binding site [chemical binding]; other site 1071400002390 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1071400002391 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1071400002392 NAD binding site [chemical binding]; other site 1071400002393 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1071400002394 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 1071400002395 catalytic Zn binding site [ion binding]; other site 1071400002396 NAD binding site [chemical binding]; other site 1071400002397 structural Zn binding site [ion binding]; other site 1071400002398 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 1071400002399 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1071400002400 NAD binding site [chemical binding]; other site 1071400002401 catalytic residues [active] 1071400002402 substrate binding site [chemical binding]; other site 1071400002403 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1071400002404 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1071400002405 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1071400002406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400002407 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400002408 putative substrate translocation pore; other site 1071400002409 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1071400002410 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1071400002411 putative active site [active] 1071400002412 putative FMN binding site [chemical binding]; other site 1071400002413 putative substrate binding site [chemical binding]; other site 1071400002414 putative catalytic residue [active] 1071400002415 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1071400002416 FMN binding site [chemical binding]; other site 1071400002417 dimer interface [polypeptide binding]; other site 1071400002418 Peptidase family C69; Region: Peptidase_C69; pfam03577 1071400002419 phosphoenolpyruvate carboxylase; Provisional; Region: PRK13655 1071400002420 phosphoenolpyruvate carboxylase, archaeal type; Region: PEPCase_arch; TIGR02751 1071400002421 OsmC-like protein; Region: OsmC; cl00767 1071400002422 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1071400002423 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 1071400002424 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1071400002425 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1071400002426 nucleotide binding site/active site [active] 1071400002427 HIT family signature motif; other site 1071400002428 catalytic residue [active] 1071400002429 VanZ like family; Region: VanZ; pfam04892 1071400002430 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1071400002431 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1071400002432 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 1071400002433 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1071400002434 PYR/PP interface [polypeptide binding]; other site 1071400002435 dimer interface [polypeptide binding]; other site 1071400002436 tetramer interface [polypeptide binding]; other site 1071400002437 TPP binding site [chemical binding]; other site 1071400002438 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1071400002439 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1071400002440 TPP-binding site [chemical binding]; other site 1071400002441 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1071400002442 peptidase domain interface [polypeptide binding]; other site 1071400002443 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 1071400002444 active site 1071400002445 catalytic triad [active] 1071400002446 calcium binding site [ion binding]; other site 1071400002447 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1071400002448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400002449 putative substrate translocation pore; other site 1071400002450 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1071400002451 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1071400002452 active site 1071400002453 motif I; other site 1071400002454 motif II; other site 1071400002455 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1071400002456 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1071400002457 putative active site [active] 1071400002458 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1071400002459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1071400002460 active site 1071400002461 phosphorylation site [posttranslational modification] 1071400002462 intermolecular recognition site; other site 1071400002463 dimerization interface [polypeptide binding]; other site 1071400002464 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1071400002465 DNA binding site [nucleotide binding] 1071400002466 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1071400002467 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1071400002468 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1071400002469 dimerization interface [polypeptide binding]; other site 1071400002470 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1071400002471 dimer interface [polypeptide binding]; other site 1071400002472 phosphorylation site [posttranslational modification] 1071400002473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1071400002474 ATP binding site [chemical binding]; other site 1071400002475 Mg2+ binding site [ion binding]; other site 1071400002476 G-X-G motif; other site 1071400002477 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1071400002478 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1071400002479 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1071400002480 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1071400002481 integrase; Provisional; Region: int; PHA02601 1071400002482 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1071400002483 Int/Topo IB signature motif; other site 1071400002484 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1071400002485 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1071400002486 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1071400002487 non-specific DNA binding site [nucleotide binding]; other site 1071400002488 salt bridge; other site 1071400002489 sequence-specific DNA binding site [nucleotide binding]; other site 1071400002490 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1071400002491 Catalytic site [active] 1071400002492 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1071400002493 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1071400002494 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825 1071400002495 ERF superfamily; Region: ERF; pfam04404 1071400002496 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 1071400002497 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1071400002498 Walker A motif; other site 1071400002499 ATP binding site [chemical binding]; other site 1071400002500 Walker B motif; other site 1071400002501 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1071400002502 dimer interface [polypeptide binding]; other site 1071400002503 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1071400002504 ssDNA binding site [nucleotide binding]; other site 1071400002505 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1071400002506 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1071400002507 YopX protein; Region: YopX; pfam09643 1071400002508 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1071400002509 Terminase small subunit; Region: Terminase_2; cl01513 1071400002510 Phage terminase large subunit; Region: Terminase_3; cl12054 1071400002511 Terminase-like family; Region: Terminase_6; pfam03237 1071400002512 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1071400002513 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 1071400002514 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1071400002515 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 1071400002516 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 1071400002517 Phage-related tail protein [Function unknown]; Region: COG5283 1071400002518 tape measure domain; Region: tape_meas_nterm; TIGR02675 1071400002519 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1071400002520 NlpC/P60 family; Region: NLPC_P60; pfam00877 1071400002521 Chaperone for protein-folding within the ER, fungal; Region: Rot1; pfam10681 1071400002522 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 1071400002523 Baseplate J-like protein; Region: Baseplate_J; cl01294 1071400002524 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1071400002525 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1071400002526 active site 1071400002527 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 1071400002528 putative deacylase active site [active] 1071400002529 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1071400002530 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1071400002531 Beta-lactamase; Region: Beta-lactamase; pfam00144 1071400002532 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1071400002533 catalytic triad [active] 1071400002534 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1071400002535 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1071400002536 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1071400002537 thymidine kinase; Provisional; Region: PRK04296 1071400002538 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1071400002539 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1071400002540 RF-1 domain; Region: RF-1; pfam00472 1071400002541 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1071400002542 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1071400002543 S-adenosylmethionine binding site [chemical binding]; other site 1071400002544 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1071400002545 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1071400002546 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1071400002547 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1071400002548 dimer interface [polypeptide binding]; other site 1071400002549 active site 1071400002550 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1071400002551 folate binding site [chemical binding]; other site 1071400002552 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1071400002553 active site 1071400002554 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1071400002555 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1071400002556 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1071400002557 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1071400002558 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1071400002559 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1071400002560 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1071400002561 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1071400002562 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1071400002563 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1071400002564 beta subunit interaction interface [polypeptide binding]; other site 1071400002565 Walker A motif; other site 1071400002566 ATP binding site [chemical binding]; other site 1071400002567 Walker B motif; other site 1071400002568 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1071400002569 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1071400002570 core domain interface [polypeptide binding]; other site 1071400002571 delta subunit interface [polypeptide binding]; other site 1071400002572 epsilon subunit interface [polypeptide binding]; other site 1071400002573 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1071400002574 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1071400002575 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1071400002576 alpha subunit interaction interface [polypeptide binding]; other site 1071400002577 Walker A motif; other site 1071400002578 ATP binding site [chemical binding]; other site 1071400002579 Walker B motif; other site 1071400002580 inhibitor binding site; inhibition site 1071400002581 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1071400002582 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1071400002583 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1071400002584 gamma subunit interface [polypeptide binding]; other site 1071400002585 epsilon subunit interface [polypeptide binding]; other site 1071400002586 LBP interface [polypeptide binding]; other site 1071400002587 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1071400002588 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1071400002589 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1071400002590 hinge; other site 1071400002591 active site 1071400002592 rod shape-determining protein MreB; Provisional; Region: PRK13930 1071400002593 MreB and similar proteins; Region: MreB_like; cd10225 1071400002594 nucleotide binding site [chemical binding]; other site 1071400002595 Mg binding site [ion binding]; other site 1071400002596 putative protofilament interaction site [polypeptide binding]; other site 1071400002597 RodZ interaction site [polypeptide binding]; other site 1071400002598 Haemolytic domain; Region: Haemolytic; pfam01809 1071400002599 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 1071400002600 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1071400002601 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1071400002602 lipoyl attachment site [posttranslational modification]; other site 1071400002603 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1071400002604 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1071400002605 Walker A/P-loop; other site 1071400002606 ATP binding site [chemical binding]; other site 1071400002607 Q-loop/lid; other site 1071400002608 ABC transporter signature motif; other site 1071400002609 Walker B; other site 1071400002610 D-loop; other site 1071400002611 H-loop/switch region; other site 1071400002612 NIL domain; Region: NIL; pfam09383 1071400002613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1071400002614 dimer interface [polypeptide binding]; other site 1071400002615 conserved gate region; other site 1071400002616 ABC-ATPase subunit interface; other site 1071400002617 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1071400002618 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1071400002619 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1071400002620 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1071400002621 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1071400002622 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1071400002623 Walker A/P-loop; other site 1071400002624 ATP binding site [chemical binding]; other site 1071400002625 Q-loop/lid; other site 1071400002626 ABC transporter signature motif; other site 1071400002627 Walker B; other site 1071400002628 D-loop; other site 1071400002629 H-loop/switch region; other site 1071400002630 Predicted transcriptional regulators [Transcription]; Region: COG1725 1071400002631 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1071400002632 DNA-binding site [nucleotide binding]; DNA binding site 1071400002633 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1071400002634 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1071400002635 Walker A/P-loop; other site 1071400002636 ATP binding site [chemical binding]; other site 1071400002637 Q-loop/lid; other site 1071400002638 ABC transporter signature motif; other site 1071400002639 Walker B; other site 1071400002640 D-loop; other site 1071400002641 H-loop/switch region; other site 1071400002642 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1071400002643 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1071400002644 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1071400002645 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1071400002646 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1071400002647 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1071400002648 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1071400002649 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1071400002650 active site 1071400002651 catalytic site [active] 1071400002652 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1071400002653 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1071400002654 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1071400002655 non-specific DNA binding site [nucleotide binding]; other site 1071400002656 salt bridge; other site 1071400002657 sequence-specific DNA binding site [nucleotide binding]; other site 1071400002658 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1071400002659 Ligand Binding Site [chemical binding]; other site 1071400002660 recombination factor protein RarA; Reviewed; Region: PRK13342 1071400002661 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1071400002662 Walker A motif; other site 1071400002663 ATP binding site [chemical binding]; other site 1071400002664 Walker B motif; other site 1071400002665 arginine finger; other site 1071400002666 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1071400002667 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1071400002668 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1071400002669 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1071400002670 RNA binding surface [nucleotide binding]; other site 1071400002671 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1071400002672 GAF domain; Region: GAF_2; pfam13185 1071400002673 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 1071400002674 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1071400002675 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1071400002676 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1071400002677 catalytic residue [active] 1071400002678 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1071400002679 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1071400002680 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1071400002681 Ligand Binding Site [chemical binding]; other site 1071400002682 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1071400002683 dimer interface [polypeptide binding]; other site 1071400002684 catalytic triad [active] 1071400002685 peroxidatic and resolving cysteines [active] 1071400002686 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1071400002687 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1071400002688 active site 1071400002689 HIGH motif; other site 1071400002690 nucleotide binding site [chemical binding]; other site 1071400002691 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1071400002692 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1071400002693 active site 1071400002694 KMSKS motif; other site 1071400002695 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1071400002696 tRNA binding surface [nucleotide binding]; other site 1071400002697 anticodon binding site; other site 1071400002698 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1071400002699 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1071400002700 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1071400002701 rod shape-determining protein MreB; Provisional; Region: PRK13927 1071400002702 MreB and similar proteins; Region: MreB_like; cd10225 1071400002703 nucleotide binding site [chemical binding]; other site 1071400002704 Mg binding site [ion binding]; other site 1071400002705 putative protofilament interaction site [polypeptide binding]; other site 1071400002706 RodZ interaction site [polypeptide binding]; other site 1071400002707 rod shape-determining protein MreC; Provisional; Region: PRK13922 1071400002708 rod shape-determining protein MreC; Region: MreC; pfam04085 1071400002709 rod shape-determining protein MreD; Region: MreD; cl01087 1071400002710 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1071400002711 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1071400002712 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1071400002713 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1071400002714 Switch I; other site 1071400002715 Switch II; other site 1071400002716 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1071400002717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1071400002718 dimer interface [polypeptide binding]; other site 1071400002719 conserved gate region; other site 1071400002720 putative PBP binding loops; other site 1071400002721 ABC-ATPase subunit interface; other site 1071400002722 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1071400002723 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1071400002724 Walker A/P-loop; other site 1071400002725 ATP binding site [chemical binding]; other site 1071400002726 Q-loop/lid; other site 1071400002727 ABC transporter signature motif; other site 1071400002728 Walker B; other site 1071400002729 D-loop; other site 1071400002730 H-loop/switch region; other site 1071400002731 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1071400002732 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1071400002733 substrate binding pocket [chemical binding]; other site 1071400002734 membrane-bound complex binding site; other site 1071400002735 hinge residues; other site 1071400002736 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1071400002737 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1071400002738 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1071400002739 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1071400002740 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1071400002741 Helix-turn-helix domain; Region: HTH_25; pfam13413 1071400002742 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1071400002743 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1071400002744 Competence-damaged protein; Region: CinA; pfam02464 1071400002745 recombinase A; Provisional; Region: recA; PRK09354 1071400002746 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1071400002747 hexamer interface [polypeptide binding]; other site 1071400002748 Walker A motif; other site 1071400002749 ATP binding site [chemical binding]; other site 1071400002750 Walker B motif; other site 1071400002751 phosphodiesterase; Provisional; Region: PRK12704 1071400002752 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1071400002753 Zn2+ binding site [ion binding]; other site 1071400002754 Mg2+ binding site [ion binding]; other site 1071400002755 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1071400002756 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1071400002757 putative active site [active] 1071400002758 metal binding site [ion binding]; metal-binding site 1071400002759 homodimer binding site [polypeptide binding]; other site 1071400002760 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1071400002761 MutS domain I; Region: MutS_I; pfam01624 1071400002762 MutS domain II; Region: MutS_II; pfam05188 1071400002763 MutS domain III; Region: MutS_III; pfam05192 1071400002764 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1071400002765 Walker A/P-loop; other site 1071400002766 ATP binding site [chemical binding]; other site 1071400002767 Q-loop/lid; other site 1071400002768 ABC transporter signature motif; other site 1071400002769 Walker B; other site 1071400002770 D-loop; other site 1071400002771 H-loop/switch region; other site 1071400002772 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1071400002773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1071400002774 ATP binding site [chemical binding]; other site 1071400002775 Mg2+ binding site [ion binding]; other site 1071400002776 G-X-G motif; other site 1071400002777 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1071400002778 ATP binding site [chemical binding]; other site 1071400002779 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1071400002780 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1071400002781 RuvA N terminal domain; Region: RuvA_N; pfam01330 1071400002782 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1071400002783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1071400002784 Walker A motif; other site 1071400002785 ATP binding site [chemical binding]; other site 1071400002786 Walker B motif; other site 1071400002787 arginine finger; other site 1071400002788 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1071400002789 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1071400002790 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1071400002791 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1071400002792 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1071400002793 Preprotein translocase subunit; Region: YajC; pfam02699 1071400002794 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1071400002795 active site 1071400002796 DNA polymerase IV; Validated; Region: PRK02406 1071400002797 DNA binding site [nucleotide binding] 1071400002798 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1071400002799 DHH family; Region: DHH; pfam01368 1071400002800 DHHA1 domain; Region: DHHA1; pfam02272 1071400002801 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1071400002802 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1071400002803 ATP binding site [chemical binding]; other site 1071400002804 Mg++ binding site [ion binding]; other site 1071400002805 motif III; other site 1071400002806 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1071400002807 nucleotide binding region [chemical binding]; other site 1071400002808 ATP-binding site [chemical binding]; other site 1071400002809 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1071400002810 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1071400002811 motif 1; other site 1071400002812 active site 1071400002813 motif 2; other site 1071400002814 motif 3; other site 1071400002815 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1071400002816 DHHA1 domain; Region: DHHA1; pfam02272 1071400002817 hypothetical protein; Provisional; Region: PRK05473 1071400002818 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1071400002819 hypothetical protein; Provisional; Region: PRK13678 1071400002820 Cell division protein ZapA; Region: ZapA; pfam05164 1071400002821 Colicin V production protein; Region: Colicin_V; pfam02674 1071400002822 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1071400002823 MutS domain III; Region: MutS_III; pfam05192 1071400002824 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1071400002825 Walker A/P-loop; other site 1071400002826 ATP binding site [chemical binding]; other site 1071400002827 Q-loop/lid; other site 1071400002828 ABC transporter signature motif; other site 1071400002829 Walker B; other site 1071400002830 D-loop; other site 1071400002831 H-loop/switch region; other site 1071400002832 Domain of unknown function DUF148; Region: DUF148; pfam02520 1071400002833 Smr domain; Region: Smr; pfam01713 1071400002834 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1071400002835 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1071400002836 catalytic residues [active] 1071400002837 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1071400002838 glutamate racemase; Provisional; Region: PRK00865 1071400002839 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1071400002840 active site 1071400002841 dimerization interface [polypeptide binding]; other site 1071400002842 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1071400002843 active site 1071400002844 metal binding site [ion binding]; metal-binding site 1071400002845 homotetramer interface [polypeptide binding]; other site 1071400002846 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1071400002847 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1071400002848 FOG: CBS domain [General function prediction only]; Region: COG0517 1071400002849 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1071400002850 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1071400002851 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 1071400002852 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1071400002853 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1071400002854 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1071400002855 active site 1071400002856 catabolite control protein A; Region: ccpA; TIGR01481 1071400002857 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1071400002858 DNA binding site [nucleotide binding] 1071400002859 domain linker motif; other site 1071400002860 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1071400002861 dimerization interface [polypeptide binding]; other site 1071400002862 effector binding site; other site 1071400002863 hypothetical protein; Validated; Region: PRK00110 1071400002864 Type II/IV secretion system protein; Region: T2SE; pfam00437 1071400002865 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1071400002866 Walker A motif; other site 1071400002867 ATP binding site [chemical binding]; other site 1071400002868 Walker B motif; other site 1071400002869 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1071400002870 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1071400002871 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1071400002872 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1071400002873 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1071400002874 propionate/acetate kinase; Provisional; Region: PRK12379 1071400002875 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1071400002876 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 1071400002877 putative active site [active] 1071400002878 putative metal binding site [ion binding]; other site 1071400002879 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1071400002880 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1071400002881 active site 1071400002882 metal binding site [ion binding]; metal-binding site 1071400002883 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1071400002884 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 1071400002885 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1071400002886 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1071400002887 active site 1071400002888 motif I; other site 1071400002889 motif II; other site 1071400002890 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1071400002891 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 1071400002892 PspC domain; Region: PspC; pfam04024 1071400002893 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1071400002894 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1071400002895 dimer interface [polypeptide binding]; other site 1071400002896 active site 1071400002897 LexA repressor; Validated; Region: PRK00215 1071400002898 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1071400002899 putative DNA binding site [nucleotide binding]; other site 1071400002900 putative Zn2+ binding site [ion binding]; other site 1071400002901 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1071400002902 Catalytic site [active] 1071400002903 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1071400002904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1071400002905 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1071400002906 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1071400002907 putative acyl-acceptor binding pocket; other site 1071400002908 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1071400002909 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1071400002910 S-adenosylmethionine binding site [chemical binding]; other site 1071400002911 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1071400002912 GIY-YIG motif/motif A; other site 1071400002913 putative active site [active] 1071400002914 putative metal binding site [ion binding]; other site 1071400002915 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1071400002916 D-lactate dehydrogenase; Validated; Region: PRK08605 1071400002917 homodimer interface [polypeptide binding]; other site 1071400002918 ligand binding site [chemical binding]; other site 1071400002919 NAD binding site [chemical binding]; other site 1071400002920 catalytic site [active] 1071400002921 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1071400002922 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1071400002923 motif II; other site 1071400002924 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1071400002925 rRNA interaction site [nucleotide binding]; other site 1071400002926 S8 interaction site; other site 1071400002927 putative laminin-1 binding site; other site 1071400002928 elongation factor Ts; Provisional; Region: tsf; PRK09377 1071400002929 UBA/TS-N domain; Region: UBA; pfam00627 1071400002930 Elongation factor TS; Region: EF_TS; pfam00889 1071400002931 Elongation factor TS; Region: EF_TS; pfam00889 1071400002932 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1071400002933 putative nucleotide binding site [chemical binding]; other site 1071400002934 uridine monophosphate binding site [chemical binding]; other site 1071400002935 homohexameric interface [polypeptide binding]; other site 1071400002936 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1071400002937 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1071400002938 hinge region; other site 1071400002939 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1071400002940 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1071400002941 catalytic residue [active] 1071400002942 putative FPP diphosphate binding site; other site 1071400002943 putative FPP binding hydrophobic cleft; other site 1071400002944 dimer interface [polypeptide binding]; other site 1071400002945 putative IPP diphosphate binding site; other site 1071400002946 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1071400002947 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1071400002948 RIP metalloprotease RseP; Region: TIGR00054 1071400002949 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1071400002950 active site 1071400002951 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1071400002952 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1071400002953 protein binding site [polypeptide binding]; other site 1071400002954 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1071400002955 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1071400002956 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1071400002957 dimer interface [polypeptide binding]; other site 1071400002958 motif 1; other site 1071400002959 active site 1071400002960 motif 2; other site 1071400002961 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1071400002962 putative deacylase active site [active] 1071400002963 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1071400002964 active site 1071400002965 motif 3; other site 1071400002966 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1071400002967 anticodon binding site; other site 1071400002968 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1071400002969 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1071400002970 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1071400002971 generic binding surface I; other site 1071400002972 generic binding surface II; other site 1071400002973 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1071400002974 active site 1071400002975 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1071400002976 active site 1071400002977 catalytic site [active] 1071400002978 substrate binding site [chemical binding]; other site 1071400002979 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1071400002980 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1071400002981 Sm and related proteins; Region: Sm_like; cl00259 1071400002982 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1071400002983 putative oligomer interface [polypeptide binding]; other site 1071400002984 putative RNA binding site [nucleotide binding]; other site 1071400002985 transcription termination factor NusA; Region: NusA; TIGR01953 1071400002986 NusA N-terminal domain; Region: NusA_N; pfam08529 1071400002987 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1071400002988 RNA binding site [nucleotide binding]; other site 1071400002989 homodimer interface [polypeptide binding]; other site 1071400002990 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1071400002991 G-X-X-G motif; other site 1071400002992 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1071400002993 G-X-X-G motif; other site 1071400002994 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1071400002995 putative RNA binding cleft [nucleotide binding]; other site 1071400002996 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1071400002997 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1071400002998 translation initiation factor IF-2; Region: IF-2; TIGR00487 1071400002999 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1071400003000 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1071400003001 G1 box; other site 1071400003002 putative GEF interaction site [polypeptide binding]; other site 1071400003003 GTP/Mg2+ binding site [chemical binding]; other site 1071400003004 Switch I region; other site 1071400003005 G2 box; other site 1071400003006 G3 box; other site 1071400003007 Switch II region; other site 1071400003008 G4 box; other site 1071400003009 G5 box; other site 1071400003010 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1071400003011 Translation-initiation factor 2; Region: IF-2; pfam11987 1071400003012 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1071400003013 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1071400003014 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1071400003015 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1071400003016 RNA binding site [nucleotide binding]; other site 1071400003017 active site 1071400003018 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1071400003019 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1071400003020 active site 1071400003021 Riboflavin kinase; Region: Flavokinase; smart00904 1071400003022 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1071400003023 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1071400003024 GrpE; Region: GrpE; pfam01025 1071400003025 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1071400003026 dimer interface [polypeptide binding]; other site 1071400003027 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1071400003028 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1071400003029 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1071400003030 nucleotide binding site [chemical binding]; other site 1071400003031 chaperone protein DnaJ; Provisional; Region: PRK14276 1071400003032 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1071400003033 HSP70 interaction site [polypeptide binding]; other site 1071400003034 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1071400003035 substrate binding site [polypeptide binding]; other site 1071400003036 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1071400003037 Zn binding sites [ion binding]; other site 1071400003038 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1071400003039 dimer interface [polypeptide binding]; other site 1071400003040 GTP-binding protein LepA; Provisional; Region: PRK05433 1071400003041 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1071400003042 G1 box; other site 1071400003043 putative GEF interaction site [polypeptide binding]; other site 1071400003044 GTP/Mg2+ binding site [chemical binding]; other site 1071400003045 Switch I region; other site 1071400003046 G2 box; other site 1071400003047 G3 box; other site 1071400003048 Switch II region; other site 1071400003049 G4 box; other site 1071400003050 G5 box; other site 1071400003051 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1071400003052 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1071400003053 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1071400003054 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1071400003055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1071400003056 S-adenosylmethionine binding site [chemical binding]; other site 1071400003057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1071400003058 RNA methyltransferase, RsmE family; Region: TIGR00046 1071400003059 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1071400003060 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1071400003061 Zn2+ binding site [ion binding]; other site 1071400003062 Mg2+ binding site [ion binding]; other site 1071400003063 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1071400003064 synthetase active site [active] 1071400003065 NTP binding site [chemical binding]; other site 1071400003066 metal binding site [ion binding]; metal-binding site 1071400003067 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1071400003068 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1071400003069 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1071400003070 putative active site [active] 1071400003071 dimerization interface [polypeptide binding]; other site 1071400003072 putative tRNAtyr binding site [nucleotide binding]; other site 1071400003073 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1071400003074 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1071400003075 motif II; other site 1071400003076 Bacterial SH3 domain; Region: SH3_3; pfam08239 1071400003077 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1071400003078 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1071400003079 active site 1071400003080 metal binding site [ion binding]; metal-binding site 1071400003081 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1071400003082 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1071400003083 dimer interface [polypeptide binding]; other site 1071400003084 motif 1; other site 1071400003085 active site 1071400003086 motif 2; other site 1071400003087 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1071400003088 anticodon binding site; other site 1071400003089 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1071400003090 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1071400003091 dimer interface [polypeptide binding]; other site 1071400003092 anticodon binding site; other site 1071400003093 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1071400003094 homodimer interface [polypeptide binding]; other site 1071400003095 motif 1; other site 1071400003096 active site 1071400003097 motif 2; other site 1071400003098 GAD domain; Region: GAD; pfam02938 1071400003099 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1071400003100 active site 1071400003101 motif 3; other site 1071400003102 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1071400003103 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1071400003104 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1071400003105 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1071400003106 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1071400003107 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1071400003108 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1071400003109 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1071400003110 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1071400003111 endonuclease IV; Provisional; Region: PRK01060 1071400003112 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1071400003113 AP (apurinic/apyrimidinic) site pocket; other site 1071400003114 DNA interaction; other site 1071400003115 Metal-binding active site; metal-binding site 1071400003116 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1071400003117 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1071400003118 Yqey-like protein; Region: YqeY; pfam09424 1071400003119 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1071400003120 PhoH-like protein; Region: PhoH; pfam02562 1071400003121 metal-binding heat shock protein; Provisional; Region: PRK00016 1071400003122 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1071400003123 GTPase Era; Reviewed; Region: era; PRK00089 1071400003124 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1071400003125 G1 box; other site 1071400003126 GTP/Mg2+ binding site [chemical binding]; other site 1071400003127 Switch I region; other site 1071400003128 G2 box; other site 1071400003129 Switch II region; other site 1071400003130 G3 box; other site 1071400003131 G4 box; other site 1071400003132 G5 box; other site 1071400003133 KH domain; Region: KH_2; pfam07650 1071400003134 DNA repair protein RecO; Region: reco; TIGR00613 1071400003135 Recombination protein O N terminal; Region: RecO_N; pfam11967 1071400003136 Recombination protein O C terminal; Region: RecO_C; pfam02565 1071400003137 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1071400003138 dimer interface [polypeptide binding]; other site 1071400003139 motif 1; other site 1071400003140 active site 1071400003141 motif 2; other site 1071400003142 motif 3; other site 1071400003143 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1071400003144 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1071400003145 DNA primase; Validated; Region: dnaG; PRK05667 1071400003146 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1071400003147 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1071400003148 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1071400003149 active site 1071400003150 metal binding site [ion binding]; metal-binding site 1071400003151 interdomain interaction site; other site 1071400003152 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1071400003153 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1071400003154 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1071400003155 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1071400003156 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1071400003157 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1071400003158 DNA binding residues [nucleotide binding] 1071400003159 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1071400003160 Family of unknown function (DUF633); Region: DUF633; pfam04816 1071400003161 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1071400003162 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1071400003163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1071400003164 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1071400003165 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1071400003166 peptidase T; Region: peptidase-T; TIGR01882 1071400003167 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1071400003168 metal binding site [ion binding]; metal-binding site 1071400003169 dimer interface [polypeptide binding]; other site 1071400003170 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1071400003171 Clp amino terminal domain; Region: Clp_N; pfam02861 1071400003172 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1071400003173 Walker A motif; other site 1071400003174 ATP binding site [chemical binding]; other site 1071400003175 Walker B motif; other site 1071400003176 arginine finger; other site 1071400003177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1071400003178 Walker A motif; other site 1071400003179 ATP binding site [chemical binding]; other site 1071400003180 Walker B motif; other site 1071400003181 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1071400003182 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1071400003183 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1071400003184 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1071400003185 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1071400003186 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1071400003187 active site 1071400003188 PHP Thumb interface [polypeptide binding]; other site 1071400003189 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1071400003190 generic binding surface I; other site 1071400003191 generic binding surface II; other site 1071400003192 pyruvate kinase; Provisional; Region: PRK06354 1071400003193 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1071400003194 domain interfaces; other site 1071400003195 active site 1071400003196 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1071400003197 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1071400003198 S1 domain; Region: S1_2; pfam13509 1071400003199 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1071400003200 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1071400003201 active site 1071400003202 Int/Topo IB signature motif; other site 1071400003203 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1071400003204 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 1071400003205 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1071400003206 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1071400003207 RNA binding surface [nucleotide binding]; other site 1071400003208 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1071400003209 active site 1071400003210 Predicted membrane protein [Function unknown]; Region: COG3601 1071400003211 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1071400003212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1071400003213 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1071400003214 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1071400003215 ATP binding site [chemical binding]; other site 1071400003216 putative Mg++ binding site [ion binding]; other site 1071400003217 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1071400003218 nucleotide binding region [chemical binding]; other site 1071400003219 ATP-binding site [chemical binding]; other site 1071400003220 cytidylate kinase; Provisional; Region: cmk; PRK00023 1071400003221 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1071400003222 CMP-binding site; other site 1071400003223 The sites determining sugar specificity; other site 1071400003224 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1071400003225 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1071400003226 RNA binding site [nucleotide binding]; other site 1071400003227 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1071400003228 RNA binding site [nucleotide binding]; other site 1071400003229 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1071400003230 RNA binding site [nucleotide binding]; other site 1071400003231 GTP-binding protein Der; Reviewed; Region: PRK00093 1071400003232 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1071400003233 G1 box; other site 1071400003234 GTP/Mg2+ binding site [chemical binding]; other site 1071400003235 Switch I region; other site 1071400003236 G2 box; other site 1071400003237 Switch II region; other site 1071400003238 G3 box; other site 1071400003239 G4 box; other site 1071400003240 G5 box; other site 1071400003241 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1071400003242 G1 box; other site 1071400003243 GTP/Mg2+ binding site [chemical binding]; other site 1071400003244 Switch I region; other site 1071400003245 G2 box; other site 1071400003246 G3 box; other site 1071400003247 Switch II region; other site 1071400003248 G4 box; other site 1071400003249 G5 box; other site 1071400003250 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1071400003251 IHF dimer interface [polypeptide binding]; other site 1071400003252 IHF - DNA interface [nucleotide binding]; other site 1071400003253 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1071400003254 binding surface 1071400003255 TPR motif; other site 1071400003256 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1071400003257 TPR motif; other site 1071400003258 binding surface 1071400003259 TPR repeat; Region: TPR_11; pfam13414 1071400003260 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1071400003261 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1071400003262 binding surface 1071400003263 TPR motif; other site 1071400003264 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1071400003265 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1071400003266 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1071400003267 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1071400003268 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1071400003269 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1071400003270 active site 1071400003271 NTP binding site [chemical binding]; other site 1071400003272 metal binding triad [ion binding]; metal-binding site 1071400003273 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1071400003274 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1071400003275 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1071400003276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1071400003277 Walker A/P-loop; other site 1071400003278 ATP binding site [chemical binding]; other site 1071400003279 Q-loop/lid; other site 1071400003280 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1071400003281 ABC transporter signature motif; other site 1071400003282 Walker B; other site 1071400003283 D-loop; other site 1071400003284 ABC transporter; Region: ABC_tran_2; pfam12848 1071400003285 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1071400003286 thymidylate synthase; Region: thym_sym; TIGR03284 1071400003287 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1071400003288 dimerization interface [polypeptide binding]; other site 1071400003289 active site 1071400003290 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1071400003291 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1071400003292 folate binding site [chemical binding]; other site 1071400003293 NADP+ binding site [chemical binding]; other site 1071400003294 EDD domain protein, DegV family; Region: DegV; TIGR00762 1071400003295 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1071400003296 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1071400003297 active site 1071400003298 catalytic triad [active] 1071400003299 oxyanion hole [active] 1071400003300 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 1071400003301 hypothetical protein; Provisional; Region: PRK13672 1071400003302 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 1071400003303 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1071400003304 GTP/Mg2+ binding site [chemical binding]; other site 1071400003305 G4 box; other site 1071400003306 G5 box; other site 1071400003307 G1 box; other site 1071400003308 Switch I region; other site 1071400003309 G2 box; other site 1071400003310 G3 box; other site 1071400003311 Switch II region; other site 1071400003312 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1071400003313 RNA/DNA hybrid binding site [nucleotide binding]; other site 1071400003314 active site 1071400003315 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1071400003316 DNA protecting protein DprA; Region: dprA; TIGR00732 1071400003317 DNA topoisomerase I; Validated; Region: PRK05582 1071400003318 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1071400003319 active site 1071400003320 interdomain interaction site; other site 1071400003321 putative metal-binding site [ion binding]; other site 1071400003322 nucleotide binding site [chemical binding]; other site 1071400003323 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1071400003324 domain I; other site 1071400003325 DNA binding groove [nucleotide binding] 1071400003326 phosphate binding site [ion binding]; other site 1071400003327 domain II; other site 1071400003328 domain III; other site 1071400003329 nucleotide binding site [chemical binding]; other site 1071400003330 catalytic site [active] 1071400003331 domain IV; other site 1071400003332 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1071400003333 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1071400003334 Peptidase family C69; Region: Peptidase_C69; pfam03577 1071400003335 Peptidase family C69; Region: Peptidase_C69; pfam03577 1071400003336 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 1071400003337 active site 1 [active] 1071400003338 dimer interface [polypeptide binding]; other site 1071400003339 hexamer interface [polypeptide binding]; other site 1071400003340 active site 2 [active] 1071400003341 glycerol kinase; Provisional; Region: glpK; PRK00047 1071400003342 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1071400003343 N- and C-terminal domain interface [polypeptide binding]; other site 1071400003344 active site 1071400003345 MgATP binding site [chemical binding]; other site 1071400003346 catalytic site [active] 1071400003347 metal binding site [ion binding]; metal-binding site 1071400003348 glycerol binding site [chemical binding]; other site 1071400003349 homotetramer interface [polypeptide binding]; other site 1071400003350 homodimer interface [polypeptide binding]; other site 1071400003351 FBP binding site [chemical binding]; other site 1071400003352 protein IIAGlc interface [polypeptide binding]; other site 1071400003353 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1071400003354 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1071400003355 active site 1071400003356 motif I; other site 1071400003357 motif II; other site 1071400003358 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1071400003359 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1071400003360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1071400003361 S-adenosylmethionine binding site [chemical binding]; other site 1071400003362 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1071400003363 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1071400003364 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1071400003365 homotetramer interface [polypeptide binding]; other site 1071400003366 FMN binding site [chemical binding]; other site 1071400003367 homodimer contacts [polypeptide binding]; other site 1071400003368 putative active site [active] 1071400003369 putative substrate binding site [chemical binding]; other site 1071400003370 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1071400003371 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1071400003372 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 1071400003373 diphosphomevalonate decarboxylase; Region: PLN02407 1071400003374 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 1071400003375 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1071400003376 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1071400003377 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 1071400003378 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1071400003379 active site 1071400003380 catalytic site [active] 1071400003381 substrate binding site [chemical binding]; other site 1071400003382 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1071400003383 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1071400003384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1071400003385 aspartate aminotransferase; Provisional; Region: PRK05764 1071400003386 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1071400003387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1071400003388 homodimer interface [polypeptide binding]; other site 1071400003389 catalytic residue [active] 1071400003390 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1071400003391 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1071400003392 putative dimer interface [polypeptide binding]; other site 1071400003393 putative anticodon binding site; other site 1071400003394 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1071400003395 homodimer interface [polypeptide binding]; other site 1071400003396 motif 1; other site 1071400003397 motif 2; other site 1071400003398 active site 1071400003399 motif 3; other site 1071400003400 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1071400003401 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1071400003402 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1071400003403 Transglycosylase; Region: Transgly; pfam00912 1071400003404 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1071400003405 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1071400003406 hypothetical protein; Provisional; Region: PRK13660 1071400003407 cell division protein GpsB; Provisional; Region: PRK14127 1071400003408 DivIVA domain; Region: DivI1A_domain; TIGR03544 1071400003409 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1071400003410 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1071400003411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1071400003412 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1071400003413 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1071400003414 RNA/DNA hybrid binding site [nucleotide binding]; other site 1071400003415 active site 1071400003416 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1071400003417 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1071400003418 Potassium binding sites [ion binding]; other site 1071400003419 Cesium cation binding sites [ion binding]; other site 1071400003420 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1071400003421 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1071400003422 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1071400003423 RNA binding surface [nucleotide binding]; other site 1071400003424 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1071400003425 active site 1071400003426 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1071400003427 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1071400003428 active site 1071400003429 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1071400003430 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1071400003431 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1071400003432 catalytic site [active] 1071400003433 subunit interface [polypeptide binding]; other site 1071400003434 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1071400003435 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 1071400003436 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1071400003437 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 1071400003438 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1071400003439 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1071400003440 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1071400003441 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1071400003442 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1071400003443 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1071400003444 EDD domain protein, DegV family; Region: DegV; TIGR00762 1071400003445 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1071400003446 hypothetical protein; Provisional; Region: PRK09609 1071400003447 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 1071400003448 active site 1071400003449 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1071400003450 catalytic center binding site [active] 1071400003451 ATP binding site [chemical binding]; other site 1071400003452 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1071400003453 GTP cyclohydrolase I; Provisional; Region: PLN03044 1071400003454 active site 1071400003455 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1071400003456 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1071400003457 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1071400003458 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1071400003459 dihydropteroate synthase; Region: DHPS; TIGR01496 1071400003460 substrate binding pocket [chemical binding]; other site 1071400003461 dimer interface [polypeptide binding]; other site 1071400003462 inhibitor binding site; inhibition site 1071400003463 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1071400003464 nudix motif; other site 1071400003465 putative acetyltransferase; Provisional; Region: PRK03624 1071400003466 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1071400003467 Coenzyme A binding pocket [chemical binding]; other site 1071400003468 LicD family; Region: LicD; cl01378 1071400003469 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 1071400003470 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1071400003471 active site 1071400003472 DNA binding site [nucleotide binding] 1071400003473 Int/Topo IB signature motif; other site 1071400003474 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1071400003475 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1071400003476 minor groove reading motif; other site 1071400003477 helix-hairpin-helix signature motif; other site 1071400003478 substrate binding pocket [chemical binding]; other site 1071400003479 active site 1071400003480 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1071400003481 DNA binding and oxoG recognition site [nucleotide binding] 1071400003482 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1071400003483 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1071400003484 SelR domain; Region: SelR; pfam01641 1071400003485 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1071400003486 DHH family; Region: DHH; pfam01368 1071400003487 DHHA2 domain; Region: DHHA2; pfam02833 1071400003488 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1071400003489 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1071400003490 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1071400003491 dimerization interface [polypeptide binding]; other site 1071400003492 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1071400003493 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1071400003494 CAP-like domain; other site 1071400003495 active site 1071400003496 primary dimer interface [polypeptide binding]; other site 1071400003497 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1071400003498 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1071400003499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1071400003500 ATP binding site [chemical binding]; other site 1071400003501 Mg2+ binding site [ion binding]; other site 1071400003502 G-X-G motif; other site 1071400003503 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1071400003504 anchoring element; other site 1071400003505 dimer interface [polypeptide binding]; other site 1071400003506 ATP binding site [chemical binding]; other site 1071400003507 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1071400003508 active site 1071400003509 putative metal-binding site [ion binding]; other site 1071400003510 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1071400003511 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1071400003512 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1071400003513 active site 1071400003514 catalytic residues [active] 1071400003515 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1071400003516 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1071400003517 Walker A motif; other site 1071400003518 ATP binding site [chemical binding]; other site 1071400003519 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1071400003520 Walker B motif; other site 1071400003521 arginine finger; other site 1071400003522 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1071400003523 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1071400003524 active site 1071400003525 HslU subunit interaction site [polypeptide binding]; other site 1071400003526 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1071400003527 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1071400003528 active site 1071400003529 DNA binding site [nucleotide binding] 1071400003530 Int/Topo IB signature motif; other site 1071400003531 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1071400003532 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1071400003533 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1071400003534 RimM N-terminal domain; Region: RimM; pfam01782 1071400003535 PRC-barrel domain; Region: PRC; pfam05239 1071400003536 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1071400003537 KH domain; Region: KH_4; pfam13083 1071400003538 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1071400003539 signal recognition particle protein; Provisional; Region: PRK10867 1071400003540 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1071400003541 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1071400003542 P loop; other site 1071400003543 GTP binding site [chemical binding]; other site 1071400003544 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1071400003545 putative DNA-binding protein; Validated; Region: PRK00118 1071400003546 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1071400003547 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1071400003548 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1071400003549 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1071400003550 P loop; other site 1071400003551 GTP binding site [chemical binding]; other site 1071400003552 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1071400003553 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1071400003554 Walker A/P-loop; other site 1071400003555 ATP binding site [chemical binding]; other site 1071400003556 Q-loop/lid; other site 1071400003557 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1071400003558 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1071400003559 ABC transporter signature motif; other site 1071400003560 Walker B; other site 1071400003561 D-loop; other site 1071400003562 H-loop/switch region; other site 1071400003563 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1071400003564 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1071400003565 dimerization interface [polypeptide binding]; other site 1071400003566 active site 1071400003567 metal binding site [ion binding]; metal-binding site 1071400003568 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1071400003569 acyl carrier protein; Provisional; Region: acpP; PRK00982 1071400003570 putative phosphate acyltransferase; Provisional; Region: PRK05331 1071400003571 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1071400003572 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1071400003573 generic binding surface II; other site 1071400003574 ssDNA binding site; other site 1071400003575 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1071400003576 ATP binding site [chemical binding]; other site 1071400003577 putative Mg++ binding site [ion binding]; other site 1071400003578 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1071400003579 nucleotide binding region [chemical binding]; other site 1071400003580 ATP-binding site [chemical binding]; other site 1071400003581 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1071400003582 DAK2 domain; Region: Dak2; pfam02734 1071400003583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1071400003584 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1071400003585 Thiamine pyrophosphokinase; Region: TPK; cd07995 1071400003586 dimerization interface [polypeptide binding]; other site 1071400003587 active site 1071400003588 thiamine binding site [chemical binding]; other site 1071400003589 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1071400003590 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1071400003591 substrate binding site [chemical binding]; other site 1071400003592 hexamer interface [polypeptide binding]; other site 1071400003593 metal binding site [ion binding]; metal-binding site 1071400003594 GTPase RsgA; Reviewed; Region: PRK00098 1071400003595 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1071400003596 RNA binding site [nucleotide binding]; other site 1071400003597 homodimer interface [polypeptide binding]; other site 1071400003598 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1071400003599 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1071400003600 GTP/Mg2+ binding site [chemical binding]; other site 1071400003601 G4 box; other site 1071400003602 G5 box; other site 1071400003603 G1 box; other site 1071400003604 Switch I region; other site 1071400003605 G2 box; other site 1071400003606 G3 box; other site 1071400003607 Switch II region; other site 1071400003608 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1071400003609 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1071400003610 active site 1071400003611 ATP binding site [chemical binding]; other site 1071400003612 substrate binding site [chemical binding]; other site 1071400003613 activation loop (A-loop); other site 1071400003614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1071400003615 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1071400003616 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1071400003617 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1071400003618 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1071400003619 Protein phosphatase 2C; Region: PP2C; pfam00481 1071400003620 active site 1071400003621 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1071400003622 NusB family; Region: NusB; pfam01029 1071400003623 putative RNA binding site [nucleotide binding]; other site 1071400003624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1071400003625 S-adenosylmethionine binding site [chemical binding]; other site 1071400003626 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1071400003627 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1071400003628 putative active site [active] 1071400003629 substrate binding site [chemical binding]; other site 1071400003630 putative cosubstrate binding site; other site 1071400003631 catalytic site [active] 1071400003632 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1071400003633 substrate binding site [chemical binding]; other site 1071400003634 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1071400003635 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1071400003636 ATP binding site [chemical binding]; other site 1071400003637 putative Mg++ binding site [ion binding]; other site 1071400003638 FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; Region: FYVE; cl17764 1071400003639 Zn binding sites [ion binding]; other site 1071400003640 phosphatidylinositol 3-phosphate binding site [chemical binding]; other site 1071400003641 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1071400003642 ATP-binding site [chemical binding]; other site 1071400003643 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1071400003644 Flavoprotein; Region: Flavoprotein; pfam02441 1071400003645 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1071400003646 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1071400003647 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1071400003648 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1071400003649 catalytic site [active] 1071400003650 G-X2-G-X-G-K; other site 1071400003651 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1071400003652 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1071400003653 Walker A/P-loop; other site 1071400003654 ATP binding site [chemical binding]; other site 1071400003655 Q-loop/lid; other site 1071400003656 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1071400003657 ABC transporter signature motif; other site 1071400003658 Walker B; other site 1071400003659 D-loop; other site 1071400003660 H-loop/switch region; other site 1071400003661 Arginine repressor [Transcription]; Region: ArgR; COG1438 1071400003662 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1071400003663 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1071400003664 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1071400003665 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1071400003666 RNA binding surface [nucleotide binding]; other site 1071400003667 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1071400003668 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1071400003669 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1071400003670 substrate binding pocket [chemical binding]; other site 1071400003671 chain length determination region; other site 1071400003672 substrate-Mg2+ binding site; other site 1071400003673 catalytic residues [active] 1071400003674 aspartate-rich region 1; other site 1071400003675 active site lid residues [active] 1071400003676 aspartate-rich region 2; other site 1071400003677 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1071400003678 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1071400003679 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1071400003680 generic binding surface II; other site 1071400003681 generic binding surface I; other site 1071400003682 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1071400003683 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1071400003684 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1071400003685 homodimer interface [polypeptide binding]; other site 1071400003686 NADP binding site [chemical binding]; other site 1071400003687 substrate binding site [chemical binding]; other site 1071400003688 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1071400003689 putative RNA binding site [nucleotide binding]; other site 1071400003690 Asp23 family; Region: Asp23; pfam03780 1071400003691 elongation factor P; Validated; Region: PRK00529 1071400003692 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1071400003693 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1071400003694 RNA binding site [nucleotide binding]; other site 1071400003695 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1071400003696 RNA binding site [nucleotide binding]; other site 1071400003697 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1071400003698 Protein of unknown function (DUF464); Region: DUF464; pfam04327 1071400003699 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1071400003700 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1071400003701 dUTPase; Region: dUTPase_2; pfam08761 1071400003702 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1071400003703 active site 1071400003704 homodimer interface [polypeptide binding]; other site 1071400003705 metal binding site [ion binding]; metal-binding site 1071400003706 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1071400003707 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1071400003708 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1071400003709 peptide binding site [polypeptide binding]; other site 1071400003710 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1071400003711 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1071400003712 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1071400003713 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1071400003714 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1071400003715 DNA binding residues [nucleotide binding] 1071400003716 putative dimer interface [polypeptide binding]; other site 1071400003717 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1071400003718 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1071400003719 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1071400003720 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1071400003721 active site 1071400003722 catalytic site [active] 1071400003723 metal binding site [ion binding]; metal-binding site 1071400003724 dimer interface [polypeptide binding]; other site 1071400003725 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 1071400003726 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1071400003727 active site residue [active] 1071400003728 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1071400003729 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1071400003730 nucleotide binding site [chemical binding]; other site 1071400003731 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1071400003732 Rhomboid family; Region: Rhomboid; pfam01694 1071400003733 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1071400003734 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1071400003735 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1071400003736 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1071400003737 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1071400003738 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1071400003739 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1071400003740 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1071400003741 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1071400003742 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1071400003743 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1071400003744 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1071400003745 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1071400003746 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1071400003747 Sugar specificity; other site 1071400003748 Pyrimidine base specificity; other site 1071400003749 ATP-binding site [chemical binding]; other site 1071400003750 YceG-like family; Region: YceG; pfam02618 1071400003751 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1071400003752 dimerization interface [polypeptide binding]; other site 1071400003753 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1071400003754 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1071400003755 putative tRNA-binding site [nucleotide binding]; other site 1071400003756 B3/4 domain; Region: B3_4; pfam03483 1071400003757 tRNA synthetase B5 domain; Region: B5; smart00874 1071400003758 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1071400003759 dimer interface [polypeptide binding]; other site 1071400003760 motif 1; other site 1071400003761 motif 3; other site 1071400003762 motif 2; other site 1071400003763 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1071400003764 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1071400003765 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1071400003766 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1071400003767 dimer interface [polypeptide binding]; other site 1071400003768 motif 1; other site 1071400003769 active site 1071400003770 motif 2; other site 1071400003771 motif 3; other site 1071400003772 Predicted transcriptional regulators [Transcription]; Region: COG1733 1071400003773 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1071400003774 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 1071400003775 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1071400003776 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1071400003777 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1071400003778 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 1071400003779 OxaA-like protein precursor; Provisional; Region: PRK02463 1071400003780 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1071400003781 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1071400003782 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1071400003783 TrkA-N domain; Region: TrkA_N; pfam02254 1071400003784 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1071400003785 TrkA-C domain; Region: TrkA_C; pfam02080 1071400003786 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1071400003787 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1071400003788 dimerization interface [polypeptide binding]; other site 1071400003789 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1071400003790 dimer interface [polypeptide binding]; other site 1071400003791 phosphorylation site [posttranslational modification] 1071400003792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1071400003793 ATP binding site [chemical binding]; other site 1071400003794 Mg2+ binding site [ion binding]; other site 1071400003795 G-X-G motif; other site 1071400003796 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1071400003797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1071400003798 active site 1071400003799 phosphorylation site [posttranslational modification] 1071400003800 intermolecular recognition site; other site 1071400003801 dimerization interface [polypeptide binding]; other site 1071400003802 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1071400003803 DNA binding site [nucleotide binding] 1071400003804 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1071400003805 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1071400003806 NAD binding site [chemical binding]; other site 1071400003807 substrate binding site [chemical binding]; other site 1071400003808 catalytic Zn binding site [ion binding]; other site 1071400003809 tetramer interface [polypeptide binding]; other site 1071400003810 structural Zn binding site [ion binding]; other site 1071400003811 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1071400003812 hypothetical protein; Provisional; Region: PRK13670 1071400003813 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1071400003814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1071400003815 S-adenosylmethionine binding site [chemical binding]; other site 1071400003816 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1071400003817 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1071400003818 Zn2+ binding site [ion binding]; other site 1071400003819 Mg2+ binding site [ion binding]; other site 1071400003820 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1071400003821 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1071400003822 active site 1071400003823 (T/H)XGH motif; other site 1071400003824 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 1071400003825 GTPase YqeH; Provisional; Region: PRK13796 1071400003826 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1071400003827 GTP/Mg2+ binding site [chemical binding]; other site 1071400003828 G4 box; other site 1071400003829 G5 box; other site 1071400003830 G1 box; other site 1071400003831 Switch I region; other site 1071400003832 G2 box; other site 1071400003833 G3 box; other site 1071400003834 Switch II region; other site 1071400003835 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1071400003836 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1071400003837 active site 1071400003838 motif I; other site 1071400003839 motif II; other site 1071400003840 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1071400003841 23S rRNA binding site [nucleotide binding]; other site 1071400003842 L21 binding site [polypeptide binding]; other site 1071400003843 L13 binding site [polypeptide binding]; other site 1071400003844 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1071400003845 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1071400003846 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1071400003847 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1071400003848 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1071400003849 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1071400003850 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1071400003851 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1071400003852 active site 1071400003853 dimer interface [polypeptide binding]; other site 1071400003854 motif 1; other site 1071400003855 motif 2; other site 1071400003856 motif 3; other site 1071400003857 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1071400003858 anticodon binding site; other site 1071400003859 primosomal protein DnaI; Reviewed; Region: PRK08939 1071400003860 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1071400003861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1071400003862 Walker A motif; other site 1071400003863 ATP binding site [chemical binding]; other site 1071400003864 Walker B motif; other site 1071400003865 arginine finger; other site 1071400003866 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1071400003867 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1071400003868 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1071400003869 ATP cone domain; Region: ATP-cone; pfam03477 1071400003870 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1071400003871 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1071400003872 CoA-binding site [chemical binding]; other site 1071400003873 ATP-binding [chemical binding]; other site 1071400003874 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1071400003875 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1071400003876 DNA binding site [nucleotide binding] 1071400003877 catalytic residue [active] 1071400003878 H2TH interface [polypeptide binding]; other site 1071400003879 putative catalytic residues [active] 1071400003880 turnover-facilitating residue; other site 1071400003881 intercalation triad [nucleotide binding]; other site 1071400003882 8OG recognition residue [nucleotide binding]; other site 1071400003883 putative reading head residues; other site 1071400003884 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1071400003885 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1071400003886 DNA polymerase I; Provisional; Region: PRK05755 1071400003887 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1071400003888 active site 1071400003889 metal binding site 1 [ion binding]; metal-binding site 1071400003890 putative 5' ssDNA interaction site; other site 1071400003891 metal binding site 3; metal-binding site 1071400003892 metal binding site 2 [ion binding]; metal-binding site 1071400003893 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1071400003894 putative DNA binding site [nucleotide binding]; other site 1071400003895 putative metal binding site [ion binding]; other site 1071400003896 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1071400003897 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1071400003898 active site 1071400003899 DNA binding site [nucleotide binding] 1071400003900 catalytic site [active] 1071400003901 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1071400003902 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1071400003903 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1071400003904 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1071400003905 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1071400003906 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1071400003907 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1071400003908 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1071400003909 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1071400003910 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1071400003911 putative tRNA-binding site [nucleotide binding]; other site 1071400003912 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1071400003913 catalytic residues [active] 1071400003914 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1071400003915 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1071400003916 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1071400003917 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1071400003918 Walker A/P-loop; other site 1071400003919 ATP binding site [chemical binding]; other site 1071400003920 Q-loop/lid; other site 1071400003921 ABC transporter signature motif; other site 1071400003922 Walker B; other site 1071400003923 D-loop; other site 1071400003924 H-loop/switch region; other site 1071400003925 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1071400003926 HIT family signature motif; other site 1071400003927 catalytic residue [active] 1071400003928 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1071400003929 SurA N-terminal domain; Region: SurA_N_3; cl07813 1071400003930 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1071400003931 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1071400003932 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1071400003933 generic binding surface I; other site 1071400003934 generic binding surface II; other site 1071400003935 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 1071400003936 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1071400003937 Zn2+ binding site [ion binding]; other site 1071400003938 Mg2+ binding site [ion binding]; other site 1071400003939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1071400003940 AAA domain; Region: AAA_23; pfam13476 1071400003941 Walker A/P-loop; other site 1071400003942 ATP binding site [chemical binding]; other site 1071400003943 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1071400003944 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1071400003945 active site 1071400003946 metal binding site [ion binding]; metal-binding site 1071400003947 DNA binding site [nucleotide binding] 1071400003948 Protein of unknown function (DUF964); Region: DUF964; cl01483 1071400003949 Transglycosylase; Region: Transgly; pfam00912 1071400003950 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1071400003951 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1071400003952 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1071400003953 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1071400003954 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1071400003955 active site 1071400003956 HIGH motif; other site 1071400003957 KMSK motif region; other site 1071400003958 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1071400003959 tRNA binding surface [nucleotide binding]; other site 1071400003960 anticodon binding site; other site 1071400003961 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 1071400003962 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1071400003963 aspartate racemase; Region: asp_race; TIGR00035 1071400003964 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 1071400003965 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1071400003966 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1071400003967 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1071400003968 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1071400003969 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1071400003970 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1071400003971 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1071400003972 active site 1071400003973 dimer interface [polypeptide binding]; other site 1071400003974 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1071400003975 Ligand Binding Site [chemical binding]; other site 1071400003976 Molecular Tunnel; other site 1071400003977 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1071400003978 Ligand Binding Site [chemical binding]; other site 1071400003979 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1071400003980 peptidase domain interface [polypeptide binding]; other site 1071400003981 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 1071400003982 active site 1071400003983 catalytic triad [active] 1071400003984 calcium binding site [ion binding]; other site 1071400003985 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1071400003986 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1071400003987 putative Zn2+ binding site [ion binding]; other site 1071400003988 putative DNA binding site [nucleotide binding]; other site 1071400003989 MarR family; Region: MarR_2; cl17246 1071400003990 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1071400003991 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1071400003992 NlpC/P60 family; Region: NLPC_P60; pfam00877 1071400003993 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1071400003994 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1071400003995 active site 1071400003996 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1071400003997 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1071400003998 peptide binding site [polypeptide binding]; other site 1071400003999 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1071400004000 putative active site [active] 1071400004001 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 1071400004002 homodimer interface [polypeptide binding]; other site 1071400004003 homotetramer interface [polypeptide binding]; other site 1071400004004 active site pocket [active] 1071400004005 cleavage site 1071400004006 CAAX protease self-immunity; Region: Abi; pfam02517 1071400004007 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1071400004008 peptidase domain interface [polypeptide binding]; other site 1071400004009 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 1071400004010 active site 1071400004011 catalytic triad [active] 1071400004012 calcium binding site [ion binding]; other site 1071400004013 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1071400004014 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1071400004015 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1071400004016 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1071400004017 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1071400004018 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1071400004019 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1071400004020 motif II; other site 1071400004021 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1071400004022 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1071400004023 active site 1071400004024 motif I; other site 1071400004025 motif II; other site 1071400004026 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1071400004027 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1071400004028 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1071400004029 Substrate-binding site [chemical binding]; other site 1071400004030 Substrate specificity [chemical binding]; other site 1071400004031 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 1071400004032 Protein of unknown function; Region: DUF3658; pfam12395 1071400004033 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1071400004034 Ligand Binding Site [chemical binding]; other site 1071400004035 dipeptidase PepV; Reviewed; Region: PRK07318 1071400004036 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1071400004037 active site 1071400004038 metal binding site [ion binding]; metal-binding site 1071400004039 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1071400004040 putative substrate binding site [chemical binding]; other site 1071400004041 putative ATP binding site [chemical binding]; other site 1071400004042 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1071400004043 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1071400004044 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1071400004045 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1071400004046 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1071400004047 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1071400004048 cell division protein ZipA; Provisional; Region: PRK03427 1071400004049 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1071400004050 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1071400004051 HIGH motif; other site 1071400004052 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1071400004053 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1071400004054 active site 1071400004055 KMSKS motif; other site 1071400004056 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1071400004057 tRNA binding surface [nucleotide binding]; other site 1071400004058 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1071400004059 active site 1071400004060 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1071400004061 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 1071400004062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400004063 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400004064 putative substrate translocation pore; other site 1071400004065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400004066 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1071400004067 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1071400004068 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1071400004069 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1071400004070 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1071400004071 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1071400004072 Cl binding site [ion binding]; other site 1071400004073 oligomer interface [polypeptide binding]; other site 1071400004074 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1071400004075 Isochorismatase family; Region: Isochorismatase; pfam00857 1071400004076 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1071400004077 catalytic triad [active] 1071400004078 conserved cis-peptide bond; other site 1071400004079 Asp23 family; Region: Asp23; pfam03780 1071400004080 Asp23 family; Region: Asp23; pfam03780 1071400004081 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1071400004082 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1071400004083 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1071400004084 putative active site [active] 1071400004085 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1071400004086 MarR family; Region: MarR_2; pfam12802 1071400004087 LicD family; Region: LicD; pfam04991 1071400004088 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 1071400004089 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1071400004090 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1071400004091 Walker A/P-loop; other site 1071400004092 ATP binding site [chemical binding]; other site 1071400004093 Q-loop/lid; other site 1071400004094 ABC transporter signature motif; other site 1071400004095 Walker B; other site 1071400004096 D-loop; other site 1071400004097 H-loop/switch region; other site 1071400004098 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1071400004099 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1071400004100 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1071400004101 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1071400004102 glutaminase active site [active] 1071400004103 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1071400004104 dimer interface [polypeptide binding]; other site 1071400004105 active site 1071400004106 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1071400004107 dimer interface [polypeptide binding]; other site 1071400004108 active site 1071400004109 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1071400004110 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1071400004111 active site 1071400004112 substrate binding site [chemical binding]; other site 1071400004113 metal binding site [ion binding]; metal-binding site 1071400004114 YbbR-like protein; Region: YbbR; pfam07949 1071400004115 YbbR-like protein; Region: YbbR; pfam07949 1071400004116 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1071400004117 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1071400004118 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 1071400004119 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1071400004120 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1071400004121 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1071400004122 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1071400004123 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1071400004124 FAD binding domain; Region: FAD_binding_4; pfam01565 1071400004125 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1071400004126 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1071400004127 active site 1071400004128 catalytic site [active] 1071400004129 substrate binding site [chemical binding]; other site 1071400004130 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1071400004131 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1071400004132 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1071400004133 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1071400004134 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1071400004135 ligand binding site [chemical binding]; other site 1071400004136 active site 1071400004137 UGI interface [polypeptide binding]; other site 1071400004138 catalytic site [active] 1071400004139 Tubby C 2; Region: Tub_2; cl02043 1071400004140 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1071400004141 SmpB-tmRNA interface; other site 1071400004142 ribonuclease R; Region: RNase_R; TIGR02063 1071400004143 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1071400004144 RNB domain; Region: RNB; pfam00773 1071400004145 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1071400004146 RNA binding site [nucleotide binding]; other site 1071400004147 Esterase/lipase [General function prediction only]; Region: COG1647 1071400004148 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 1071400004149 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1071400004150 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1071400004151 Cl- selectivity filter; other site 1071400004152 Cl- binding residues [ion binding]; other site 1071400004153 pore gating glutamate residue; other site 1071400004154 dimer interface [polypeptide binding]; other site 1071400004155 H+/Cl- coupling transport residue; other site 1071400004156 TrkA-C domain; Region: TrkA_C; pfam02080 1071400004157 DNA polymerase III subunits gamma and tau; Validated; Region: PRK08691 1071400004158 enolase; Provisional; Region: eno; PRK00077 1071400004159 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1071400004160 dimer interface [polypeptide binding]; other site 1071400004161 metal binding site [ion binding]; metal-binding site 1071400004162 substrate binding pocket [chemical binding]; other site 1071400004163 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1071400004164 triosephosphate isomerase; Provisional; Region: PRK14565 1071400004165 substrate binding site [chemical binding]; other site 1071400004166 dimer interface [polypeptide binding]; other site 1071400004167 catalytic triad [active] 1071400004168 Phosphoglycerate kinase; Region: PGK; pfam00162 1071400004169 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1071400004170 substrate binding site [chemical binding]; other site 1071400004171 hinge regions; other site 1071400004172 ADP binding site [chemical binding]; other site 1071400004173 catalytic site [active] 1071400004174 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1071400004175 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1071400004176 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1071400004177 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1071400004178 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1071400004179 Coenzyme A binding pocket [chemical binding]; other site 1071400004180 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1071400004181 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1071400004182 Zn binding site [ion binding]; other site 1071400004183 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1071400004184 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1071400004185 Zn binding site [ion binding]; other site 1071400004186 Clp protease; Region: CLP_protease; pfam00574 1071400004187 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1071400004188 oligomer interface [polypeptide binding]; other site 1071400004189 active site residues [active] 1071400004190 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1071400004191 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1071400004192 putative NAD(P) binding site [chemical binding]; other site 1071400004193 putative substrate binding site [chemical binding]; other site 1071400004194 catalytic Zn binding site [ion binding]; other site 1071400004195 structural Zn binding site [ion binding]; other site 1071400004196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1071400004197 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1071400004198 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1071400004199 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1071400004200 phosphate binding site [ion binding]; other site 1071400004201 putative substrate binding pocket [chemical binding]; other site 1071400004202 dimer interface [polypeptide binding]; other site 1071400004203 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1071400004204 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1071400004205 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1071400004206 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1071400004207 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1071400004208 excinuclease ABC subunit B; Provisional; Region: PRK05298 1071400004209 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1071400004210 ATP binding site [chemical binding]; other site 1071400004211 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1071400004212 nucleotide binding region [chemical binding]; other site 1071400004213 ATP-binding site [chemical binding]; other site 1071400004214 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1071400004215 UvrB/uvrC motif; Region: UVR; pfam02151 1071400004216 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1071400004217 Zn2+ binding site [ion binding]; other site 1071400004218 Mg2+ binding site [ion binding]; other site 1071400004219 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1071400004220 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1071400004221 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1071400004222 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1071400004223 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1071400004224 active site 1071400004225 tetramer interface; other site 1071400004226 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1071400004227 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1071400004228 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1071400004229 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1071400004230 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1071400004231 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1071400004232 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1071400004233 Hpr binding site; other site 1071400004234 active site 1071400004235 homohexamer subunit interaction site [polypeptide binding]; other site 1071400004236 Predicted membrane protein [Function unknown]; Region: COG1950 1071400004237 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1071400004238 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1071400004239 PhoU domain; Region: PhoU; pfam01895 1071400004240 PhoU domain; Region: PhoU; pfam01895 1071400004241 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1071400004242 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1071400004243 Walker A/P-loop; other site 1071400004244 ATP binding site [chemical binding]; other site 1071400004245 Q-loop/lid; other site 1071400004246 ABC transporter signature motif; other site 1071400004247 Walker B; other site 1071400004248 D-loop; other site 1071400004249 H-loop/switch region; other site 1071400004250 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 1071400004251 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1071400004252 Walker A/P-loop; other site 1071400004253 ATP binding site [chemical binding]; other site 1071400004254 Q-loop/lid; other site 1071400004255 ABC transporter signature motif; other site 1071400004256 Walker B; other site 1071400004257 D-loop; other site 1071400004258 H-loop/switch region; other site 1071400004259 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1071400004260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1071400004261 dimer interface [polypeptide binding]; other site 1071400004262 conserved gate region; other site 1071400004263 putative PBP binding loops; other site 1071400004264 ABC-ATPase subunit interface; other site 1071400004265 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1071400004266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1071400004267 dimer interface [polypeptide binding]; other site 1071400004268 conserved gate region; other site 1071400004269 putative PBP binding loops; other site 1071400004270 ABC-ATPase subunit interface; other site 1071400004271 PBP superfamily domain; Region: PBP_like_2; cl17296 1071400004272 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1071400004273 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1071400004274 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1071400004275 dimer interface [polypeptide binding]; other site 1071400004276 phosphorylation site [posttranslational modification] 1071400004277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1071400004278 ATP binding site [chemical binding]; other site 1071400004279 Mg2+ binding site [ion binding]; other site 1071400004280 G-X-G motif; other site 1071400004281 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1071400004282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1071400004283 active site 1071400004284 phosphorylation site [posttranslational modification] 1071400004285 intermolecular recognition site; other site 1071400004286 dimerization interface [polypeptide binding]; other site 1071400004287 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1071400004288 DNA binding site [nucleotide binding] 1071400004289 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1071400004290 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1071400004291 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1071400004292 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1071400004293 RF-1 domain; Region: RF-1; pfam00472 1071400004294 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 1071400004295 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1071400004296 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1071400004297 nucleotide binding region [chemical binding]; other site 1071400004298 ATP-binding site [chemical binding]; other site 1071400004299 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1071400004300 30S subunit binding site; other site 1071400004301 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1071400004302 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1071400004303 active site 1071400004304 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1071400004305 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1071400004306 ATP binding site [chemical binding]; other site 1071400004307 putative Mg++ binding site [ion binding]; other site 1071400004308 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1071400004309 ATP-binding site [chemical binding]; other site 1071400004310 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1071400004311 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1071400004312 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1071400004313 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1071400004314 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1071400004315 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1071400004316 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1071400004317 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1071400004318 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1071400004319 Mg++ binding site [ion binding]; other site 1071400004320 putative catalytic motif [active] 1071400004321 substrate binding site [chemical binding]; other site 1071400004322 LrgA family; Region: LrgA; pfam03788 1071400004323 LrgB-like family; Region: LrgB; cl00596 1071400004324 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1071400004325 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1071400004326 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1071400004327 ring oligomerisation interface [polypeptide binding]; other site 1071400004328 ATP/Mg binding site [chemical binding]; other site 1071400004329 stacking interactions; other site 1071400004330 hinge regions; other site 1071400004331 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1071400004332 oligomerisation interface [polypeptide binding]; other site 1071400004333 mobile loop; other site 1071400004334 roof hairpin; other site 1071400004335 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1071400004336 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1071400004337 CoA binding domain; Region: CoA_binding; pfam02629 1071400004338 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1071400004339 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1071400004340 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1071400004341 ABC transporter; Region: ABC_tran_2; pfam12848 1071400004342 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1071400004343 UGMP family protein; Validated; Region: PRK09604 1071400004344 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1071400004345 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1071400004346 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1071400004347 Coenzyme A binding pocket [chemical binding]; other site 1071400004348 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1071400004349 Glycoprotease family; Region: Peptidase_M22; pfam00814 1071400004350 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 1071400004351 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1071400004352 active site 1071400004353 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1071400004354 active site 1071400004355 Predicted methyltransferases [General function prediction only]; Region: COG0313 1071400004356 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1071400004357 putative SAM binding site [chemical binding]; other site 1071400004358 putative homodimer interface [polypeptide binding]; other site 1071400004359 Protein of unknown function (DUF972); Region: DUF972; pfam06156 1071400004360 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1071400004361 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1071400004362 Protein of unknown function (DUF970); Region: DUF970; cl17525 1071400004363 thymidylate kinase; Validated; Region: tmk; PRK00698 1071400004364 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1071400004365 TMP-binding site; other site 1071400004366 ATP-binding site [chemical binding]; other site 1071400004367 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1071400004368 recombination protein RecR; Reviewed; Region: recR; PRK00076 1071400004369 RecR protein; Region: RecR; pfam02132 1071400004370 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1071400004371 putative active site [active] 1071400004372 putative metal-binding site [ion binding]; other site 1071400004373 tetramer interface [polypeptide binding]; other site 1071400004374 hypothetical protein; Validated; Region: PRK00153 1071400004375 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1071400004376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1071400004377 Walker A motif; other site 1071400004378 ATP binding site [chemical binding]; other site 1071400004379 Walker B motif; other site 1071400004380 arginine finger; other site 1071400004381 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1071400004382 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1071400004383 nucleoside/Zn binding site; other site 1071400004384 dimer interface [polypeptide binding]; other site 1071400004385 catalytic motif [active] 1071400004386 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1071400004387 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1071400004388 S-adenosylmethionine binding site [chemical binding]; other site 1071400004389 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1071400004390 catalytic residues [active] 1071400004391 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 1071400004392 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1071400004393 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1071400004394 active site 1071400004395 dimer interface [polypeptide binding]; other site 1071400004396 catalytic residues [active] 1071400004397 effector binding site; other site 1071400004398 R2 peptide binding site; other site 1071400004399 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1071400004400 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1071400004401 dimer interface [polypeptide binding]; other site 1071400004402 putative radical transfer pathway; other site 1071400004403 diiron center [ion binding]; other site 1071400004404 tyrosyl radical; other site 1071400004405 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1071400004406 D-lactate dehydrogenase; Validated; Region: PRK08605 1071400004407 homodimer interface [polypeptide binding]; other site 1071400004408 ligand binding site [chemical binding]; other site 1071400004409 NAD binding site [chemical binding]; other site 1071400004410 catalytic site [active] 1071400004411 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1071400004412 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1071400004413 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1071400004414 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1071400004415 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1071400004416 NAD binding site [chemical binding]; other site 1071400004417 homodimer interface [polypeptide binding]; other site 1071400004418 active site 1071400004419 substrate binding site [chemical binding]; other site 1071400004420 galactokinase; Provisional; Region: PRK05322 1071400004421 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1071400004422 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1071400004423 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1071400004424 Predicted integral membrane protein [Function unknown]; Region: COG0392 1071400004425 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1071400004426 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1071400004427 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1071400004428 peripheral dimer interface [polypeptide binding]; other site 1071400004429 core dimer interface [polypeptide binding]; other site 1071400004430 L10 interface [polypeptide binding]; other site 1071400004431 L11 interface [polypeptide binding]; other site 1071400004432 putative EF-Tu interaction site [polypeptide binding]; other site 1071400004433 putative EF-G interaction site [polypeptide binding]; other site 1071400004434 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1071400004435 23S rRNA interface [nucleotide binding]; other site 1071400004436 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1071400004437 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1071400004438 mRNA/rRNA interface [nucleotide binding]; other site 1071400004439 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1071400004440 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1071400004441 23S rRNA interface [nucleotide binding]; other site 1071400004442 L7/L12 interface [polypeptide binding]; other site 1071400004443 putative thiostrepton binding site; other site 1071400004444 L25 interface [polypeptide binding]; other site 1071400004445 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1071400004446 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1071400004447 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1071400004448 putative homodimer interface [polypeptide binding]; other site 1071400004449 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1071400004450 heterodimer interface [polypeptide binding]; other site 1071400004451 homodimer interface [polypeptide binding]; other site 1071400004452 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1071400004453 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1071400004454 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1071400004455 YacP-like NYN domain; Region: NYN_YacP; pfam05991 1071400004456 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1071400004457 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1071400004458 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1071400004459 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1071400004460 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1071400004461 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1071400004462 active site 1071400004463 HIGH motif; other site 1071400004464 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1071400004465 KMSKS motif; other site 1071400004466 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1071400004467 tRNA binding surface [nucleotide binding]; other site 1071400004468 anticodon binding site; other site 1071400004469 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1071400004470 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1071400004471 active site 1071400004472 HIGH motif; other site 1071400004473 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1071400004474 active site 1071400004475 KMSKS motif; other site 1071400004476 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1071400004477 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1071400004478 putative active site [active] 1071400004479 DNA repair protein RadA; Provisional; Region: PRK11823 1071400004480 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1071400004481 Walker A motif/ATP binding site; other site 1071400004482 ATP binding site [chemical binding]; other site 1071400004483 Walker B motif; other site 1071400004484 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1071400004485 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1071400004486 trimer interface [polypeptide binding]; other site 1071400004487 active site 1071400004488 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1071400004489 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1071400004490 active site 1071400004491 dimer interface [polypeptide binding]; other site 1071400004492 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1071400004493 trimer interface [polypeptide binding]; other site 1071400004494 active site 1071400004495 G bulge; other site 1071400004496 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1071400004497 catalytic core [active] 1071400004498 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1071400004499 Predicted permeases [General function prediction only]; Region: COG0679 1071400004500 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1071400004501 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1071400004502 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 1071400004503 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1071400004504 active site 1071400004505 phosphorylation site [posttranslational modification] 1071400004506 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1071400004507 active pocket/dimerization site; other site 1071400004508 active site 1071400004509 phosphorylation site [posttranslational modification] 1071400004510 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1071400004511 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1071400004512 active site 1071400004513 motif I; other site 1071400004514 motif II; other site 1071400004515 homoserine kinase; Provisional; Region: PRK01212 1071400004516 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1071400004517 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1071400004518 hypothetical protein; Provisional; Region: PRK04351 1071400004519 SprT homologues; Region: SprT; cl01182 1071400004520 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1071400004521 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1071400004522 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1071400004523 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1071400004524 RNA binding site [nucleotide binding]; other site 1071400004525 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1071400004526 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1071400004527 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1071400004528 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1071400004529 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1071400004530 motif II; other site 1071400004531 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1071400004532 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1071400004533 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1071400004534 homodimer interface [polypeptide binding]; other site 1071400004535 NAD binding pocket [chemical binding]; other site 1071400004536 ATP binding pocket [chemical binding]; other site 1071400004537 Mg binding site [ion binding]; other site 1071400004538 active-site loop [active] 1071400004539 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1071400004540 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1071400004541 active site 1071400004542 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1071400004543 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1071400004544 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1071400004545 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1071400004546 DNA-binding site [nucleotide binding]; DNA binding site 1071400004547 UTRA domain; Region: UTRA; pfam07702 1071400004548 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1071400004549 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1071400004550 active site 1071400004551 dimer interface [polypeptide binding]; other site 1071400004552 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1071400004553 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1071400004554 putative phosphoesterase; Region: acc_ester; TIGR03729 1071400004555 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1071400004556 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1071400004557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400004558 putative substrate translocation pore; other site 1071400004559 POT family; Region: PTR2; cl17359 1071400004560 methionine cluster; other site 1071400004561 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 1071400004562 active site 1071400004563 phosphorylation site [posttranslational modification] 1071400004564 metal binding site [ion binding]; metal-binding site 1071400004565 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1071400004566 active site 1071400004567 P-loop; other site 1071400004568 phosphorylation site [posttranslational modification] 1071400004569 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1071400004570 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1071400004571 active site 1071400004572 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1071400004573 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1071400004574 Phage tail protein; Region: Sipho_tail; cl17486 1071400004575 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1071400004576 NlpC/P60 family; Region: NLPC_P60; cl17555 1071400004577 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1071400004578 Protein of unknown function (DUF1268); Region: DUF1268; pfam06896 1071400004579 Phage major tail protein; Region: Phage_tail; pfam04630 1071400004580 Protein of unknown function (DUF806); Region: DUF806; pfam05657 1071400004581 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 1071400004582 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1071400004583 Phage capsid family; Region: Phage_capsid; pfam05065 1071400004584 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1071400004585 oligomer interface [polypeptide binding]; other site 1071400004586 active site residues [active] 1071400004587 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1071400004588 Phage portal protein; Region: Phage_portal; pfam04860 1071400004589 Phage Terminase; Region: Terminase_1; pfam03354 1071400004590 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1071400004591 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1071400004592 active site 1071400004593 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 1071400004594 Uncharacterized conserved protein [Function unknown]; Region: COG4983 1071400004595 D5 N terminal like; Region: D5_N; pfam08706 1071400004596 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1071400004597 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 1071400004598 Protein of unknown function (DUF669); Region: DUF669; pfam05037 1071400004599 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1071400004600 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1071400004601 ATP binding site [chemical binding]; other site 1071400004602 putative Mg++ binding site [ion binding]; other site 1071400004603 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1071400004604 nucleotide binding region [chemical binding]; other site 1071400004605 ATP-binding site [chemical binding]; other site 1071400004606 Double zinc ribbon; Region: DZR; pfam12773 1071400004607 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 1071400004608 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 1071400004609 AAA domain; Region: AAA_24; pfam13479 1071400004610 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 1071400004611 Domain of unknown function (DUF771); Region: DUF771; cl09962 1071400004612 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1071400004613 Integrase core domain; Region: rve; pfam00665 1071400004614 transposase/IS protein; Provisional; Region: PRK09183 1071400004615 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1071400004616 Walker A motif; other site 1071400004617 ATP binding site [chemical binding]; other site 1071400004618 Walker B motif; other site 1071400004619 arginine finger; other site 1071400004620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1071400004621 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1071400004622 non-specific DNA binding site [nucleotide binding]; other site 1071400004623 salt bridge; other site 1071400004624 sequence-specific DNA binding site [nucleotide binding]; other site 1071400004625 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1071400004626 Catalytic site [active] 1071400004627 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1071400004628 Int/Topo IB signature motif; other site 1071400004629 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1071400004630 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1071400004631 dimer interface [polypeptide binding]; other site 1071400004632 putative anticodon binding site; other site 1071400004633 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1071400004634 motif 1; other site 1071400004635 active site 1071400004636 motif 2; other site 1071400004637 motif 3; other site 1071400004638 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1071400004639 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1071400004640 FMN binding site [chemical binding]; other site 1071400004641 active site 1071400004642 catalytic residues [active] 1071400004643 substrate binding site [chemical binding]; other site 1071400004644 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1071400004645 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1071400004646 dimerization interface [polypeptide binding]; other site 1071400004647 domain crossover interface; other site 1071400004648 redox-dependent activation switch; other site 1071400004649 FtsH Extracellular; Region: FtsH_ext; pfam06480 1071400004650 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1071400004651 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1071400004652 Walker A motif; other site 1071400004653 ATP binding site [chemical binding]; other site 1071400004654 Walker B motif; other site 1071400004655 arginine finger; other site 1071400004656 Peptidase family M41; Region: Peptidase_M41; pfam01434 1071400004657 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1071400004658 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1071400004659 active site 1071400004660 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1071400004661 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1071400004662 Ligand Binding Site [chemical binding]; other site 1071400004663 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1071400004664 hypothetical protein; Provisional; Region: PRK08582 1071400004665 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1071400004666 RNA binding site [nucleotide binding]; other site 1071400004667 Septum formation initiator; Region: DivIC; cl17659 1071400004668 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1071400004669 RNA binding surface [nucleotide binding]; other site 1071400004670 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1071400004671 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1071400004672 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1071400004673 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1071400004674 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1071400004675 ATP binding site [chemical binding]; other site 1071400004676 putative Mg++ binding site [ion binding]; other site 1071400004677 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1071400004678 nucleotide binding region [chemical binding]; other site 1071400004679 ATP-binding site [chemical binding]; other site 1071400004680 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1071400004681 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1071400004682 putative active site [active] 1071400004683 catalytic residue [active] 1071400004684 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1071400004685 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1071400004686 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1071400004687 NAD binding site [chemical binding]; other site 1071400004688 dimer interface [polypeptide binding]; other site 1071400004689 substrate binding site [chemical binding]; other site 1071400004690 FOG: CBS domain [General function prediction only]; Region: COG0517 1071400004691 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1071400004692 PemK-like protein; Region: PemK; pfam02452 1071400004693 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1071400004694 alanine racemase; Reviewed; Region: alr; PRK00053 1071400004695 active site 1071400004696 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1071400004697 dimer interface [polypeptide binding]; other site 1071400004698 substrate binding site [chemical binding]; other site 1071400004699 catalytic residues [active] 1071400004700 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1071400004701 helicase 45; Provisional; Region: PTZ00424 1071400004702 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1071400004703 ATP binding site [chemical binding]; other site 1071400004704 Mg++ binding site [ion binding]; other site 1071400004705 motif III; other site 1071400004706 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1071400004707 nucleotide binding region [chemical binding]; other site 1071400004708 ATP-binding site [chemical binding]; other site 1071400004709 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1071400004710 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1071400004711 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1071400004712 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1071400004713 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1071400004714 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1071400004715 active site 1071400004716 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1071400004717 active site 1071400004718 catalytic site [active] 1071400004719 drug efflux system protein MdtG; Provisional; Region: PRK09874 1071400004720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400004721 putative substrate translocation pore; other site 1071400004722 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1071400004723 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1071400004724 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1071400004725 hinge; other site 1071400004726 active site 1071400004727 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1071400004728 Protein export membrane protein; Region: SecD_SecF; cl14618 1071400004729 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1071400004730 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1071400004731 CTP synthetase; Validated; Region: pyrG; PRK05380 1071400004732 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1071400004733 Catalytic site [active] 1071400004734 active site 1071400004735 UTP binding site [chemical binding]; other site 1071400004736 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1071400004737 active site 1071400004738 putative oxyanion hole; other site 1071400004739 catalytic triad [active] 1071400004740 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1071400004741 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1071400004742 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1071400004743 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1071400004744 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1071400004745 Zn2+ binding site [ion binding]; other site 1071400004746 Mg2+ binding site [ion binding]; other site 1071400004747 sugar phosphate phosphatase; Provisional; Region: PRK10513 1071400004748 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1071400004749 active site 1071400004750 motif I; other site 1071400004751 motif II; other site 1071400004752 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1071400004753 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 1071400004754 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1071400004755 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1071400004756 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1071400004757 active site 1071400004758 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1071400004759 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1071400004760 Substrate binding site; other site 1071400004761 Mg++ binding site; other site 1071400004762 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1071400004763 active site 1071400004764 substrate binding site [chemical binding]; other site 1071400004765 CoA binding site [chemical binding]; other site 1071400004766 pur operon repressor; Provisional; Region: PRK09213 1071400004767 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1071400004768 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1071400004769 active site 1071400004770 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1071400004771 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1071400004772 ABC-ATPase subunit interface; other site 1071400004773 dimer interface [polypeptide binding]; other site 1071400004774 putative PBP binding regions; other site 1071400004775 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1071400004776 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1071400004777 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1071400004778 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1071400004779 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1071400004780 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1071400004781 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1071400004782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1071400004783 S-adenosylmethionine binding site [chemical binding]; other site 1071400004784 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1071400004785 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1071400004786 putative active site [active] 1071400004787 putative metal binding site [ion binding]; other site 1071400004788 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1071400004789 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1071400004790 active site 1071400004791 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1071400004792 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1071400004793 active site 1071400004794 HIGH motif; other site 1071400004795 KMSKS motif; other site 1071400004796 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1071400004797 tRNA binding surface [nucleotide binding]; other site 1071400004798 anticodon binding site; other site 1071400004799 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1071400004800 putative tRNA-binding site [nucleotide binding]; other site 1071400004801 dimer interface [polypeptide binding]; other site 1071400004802 Protein of unknown function DUF72; Region: DUF72; pfam01904 1071400004803 NAD-dependent deacetylase; Provisional; Region: PRK00481 1071400004804 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 1071400004805 NAD+ binding site [chemical binding]; other site 1071400004806 substrate binding site [chemical binding]; other site 1071400004807 putative Zn binding site [ion binding]; other site 1071400004808 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1071400004809 homodimer interface [polypeptide binding]; other site 1071400004810 catalytic residues [active] 1071400004811 NAD binding site [chemical binding]; other site 1071400004812 substrate binding pocket [chemical binding]; other site 1071400004813 flexible flap; other site 1071400004814 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1071400004815 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1071400004816 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1071400004817 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1071400004818 active site 1071400004819 HIGH motif; other site 1071400004820 dimer interface [polypeptide binding]; other site 1071400004821 KMSKS motif; other site 1071400004822 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 1071400004823 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1071400004824 putative ligand binding site [chemical binding]; other site 1071400004825 NAD binding site [chemical binding]; other site 1071400004826 catalytic site [active] 1071400004827 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1071400004828 Part of AAA domain; Region: AAA_19; pfam13245 1071400004829 Family description; Region: UvrD_C_2; pfam13538 1071400004830 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1071400004831 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1071400004832 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1071400004833 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1071400004834 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1071400004835 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1071400004836 substrate binding pocket [chemical binding]; other site 1071400004837 chain length determination region; other site 1071400004838 substrate-Mg2+ binding site; other site 1071400004839 catalytic residues [active] 1071400004840 aspartate-rich region 1; other site 1071400004841 active site lid residues [active] 1071400004842 aspartate-rich region 2; other site 1071400004843 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1071400004844 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1071400004845 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1071400004846 Walker A/P-loop; other site 1071400004847 ATP binding site [chemical binding]; other site 1071400004848 Q-loop/lid; other site 1071400004849 ABC transporter signature motif; other site 1071400004850 Walker B; other site 1071400004851 D-loop; other site 1071400004852 H-loop/switch region; other site 1071400004853 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1071400004854 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1071400004855 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1071400004856 Walker A/P-loop; other site 1071400004857 ATP binding site [chemical binding]; other site 1071400004858 Q-loop/lid; other site 1071400004859 ABC transporter signature motif; other site 1071400004860 Walker B; other site 1071400004861 D-loop; other site 1071400004862 H-loop/switch region; other site 1071400004863 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1071400004864 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1071400004865 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1071400004866 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1071400004867 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1071400004868 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1071400004869 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1071400004870 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1071400004871 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1071400004872 Walker A/P-loop; other site 1071400004873 ATP binding site [chemical binding]; other site 1071400004874 Q-loop/lid; other site 1071400004875 ABC transporter signature motif; other site 1071400004876 Walker B; other site 1071400004877 D-loop; other site 1071400004878 H-loop/switch region; other site 1071400004879 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1071400004880 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1071400004881 ABC-ATPase subunit interface; other site 1071400004882 dimer interface [polypeptide binding]; other site 1071400004883 putative PBP binding regions; other site 1071400004884 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1071400004885 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1071400004886 intersubunit interface [polypeptide binding]; other site 1071400004887 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1071400004888 heme-binding site [chemical binding]; other site 1071400004889 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760 1071400004890 heme-binding site [chemical binding]; other site 1071400004891 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1071400004892 heme-binding site [chemical binding]; other site 1071400004893 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1071400004894 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1071400004895 Sulfatase; Region: Sulfatase; pfam00884 1071400004896 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1071400004897 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1071400004898 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1071400004899 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1071400004900 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1071400004901 putative ADP-binding pocket [chemical binding]; other site 1071400004902 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1071400004903 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1071400004904 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1071400004905 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1071400004906 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1071400004907 dimerization domain swap beta strand [polypeptide binding]; other site 1071400004908 regulatory protein interface [polypeptide binding]; other site 1071400004909 active site 1071400004910 regulatory phosphorylation site [posttranslational modification]; other site 1071400004911 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1071400004912 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1071400004913 Walker A motif; other site 1071400004914 ATP binding site [chemical binding]; other site 1071400004915 Walker B motif; other site 1071400004916 arginine finger; other site 1071400004917 UvrB/uvrC motif; Region: UVR; pfam02151 1071400004918 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1071400004919 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1071400004920 Walker A motif; other site 1071400004921 ATP binding site [chemical binding]; other site 1071400004922 Walker B motif; other site 1071400004923 arginine finger; other site 1071400004924 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1071400004925 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1071400004926 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1071400004927 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1071400004928 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1071400004929 non-specific DNA binding site [nucleotide binding]; other site 1071400004930 salt bridge; other site 1071400004931 sequence-specific DNA binding site [nucleotide binding]; other site 1071400004932 Peptidase family C69; Region: Peptidase_C69; pfam03577 1071400004933 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1071400004934 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1071400004935 G1 box; other site 1071400004936 putative GEF interaction site [polypeptide binding]; other site 1071400004937 GTP/Mg2+ binding site [chemical binding]; other site 1071400004938 Switch I region; other site 1071400004939 G2 box; other site 1071400004940 G3 box; other site 1071400004941 Switch II region; other site 1071400004942 G4 box; other site 1071400004943 G5 box; other site 1071400004944 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1071400004945 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1071400004946 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1071400004947 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 1071400004948 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1071400004949 active site 1071400004950 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1071400004951 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1071400004952 hypothetical protein; Provisional; Region: PRK13662 1071400004953 RecX family; Region: RecX; cl00936 1071400004954 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1071400004955 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1071400004956 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1071400004957 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1071400004958 active site 1071400004959 homodimer interface [polypeptide binding]; other site 1071400004960 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1071400004961 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1071400004962 Ligand binding site; other site 1071400004963 Putative Catalytic site; other site 1071400004964 DXD motif; other site 1071400004965 Photosystem II protein; Region: PSII; cl08223 1071400004966 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 1071400004967 Predicted membrane protein [Function unknown]; Region: COG2246 1071400004968 GtrA-like protein; Region: GtrA; pfam04138 1071400004969 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1071400004970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1071400004971 dimer interface [polypeptide binding]; other site 1071400004972 conserved gate region; other site 1071400004973 putative PBP binding loops; other site 1071400004974 ABC-ATPase subunit interface; other site 1071400004975 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1071400004976 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1071400004977 substrate binding pocket [chemical binding]; other site 1071400004978 membrane-bound complex binding site; other site 1071400004979 hinge residues; other site 1071400004980 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1071400004981 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1071400004982 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1071400004983 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1071400004984 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1071400004985 ATP binding site [chemical binding]; other site 1071400004986 putative Mg++ binding site [ion binding]; other site 1071400004987 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1071400004988 nucleotide binding region [chemical binding]; other site 1071400004989 ATP-binding site [chemical binding]; other site 1071400004990 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1071400004991 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1071400004992 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1071400004993 active site 1071400004994 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1071400004995 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1071400004996 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1071400004997 putative active site [active] 1071400004998 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1071400004999 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1071400005000 N- and C-terminal domain interface [polypeptide binding]; other site 1071400005001 active site 1071400005002 catalytic site [active] 1071400005003 metal binding site [ion binding]; metal-binding site 1071400005004 carbohydrate binding site [chemical binding]; other site 1071400005005 ATP binding site [chemical binding]; other site 1071400005006 GntP family permease; Region: GntP_permease; pfam02447 1071400005007 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1071400005008 BioY family; Region: BioY; pfam02632 1071400005009 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1071400005010 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1071400005011 putative DNA binding site [nucleotide binding]; other site 1071400005012 putative Zn2+ binding site [ion binding]; other site 1071400005013 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1071400005014 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1071400005015 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 1071400005016 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1071400005017 NAD binding site [chemical binding]; other site 1071400005018 homotetramer interface [polypeptide binding]; other site 1071400005019 homodimer interface [polypeptide binding]; other site 1071400005020 substrate binding site [chemical binding]; other site 1071400005021 active site 1071400005022 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1071400005023 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1071400005024 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1071400005025 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1071400005026 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1071400005027 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1071400005028 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1071400005029 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1071400005030 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1071400005031 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1071400005032 carboxyltransferase (CT) interaction site; other site 1071400005033 biotinylation site [posttranslational modification]; other site 1071400005034 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1071400005035 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1071400005036 dimer interface [polypeptide binding]; other site 1071400005037 active site 1071400005038 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1071400005039 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1071400005040 NAD(P) binding site [chemical binding]; other site 1071400005041 active site 1071400005042 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1071400005043 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1071400005044 acyl carrier protein; Provisional; Region: acpP; PRK00982 1071400005045 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1071400005046 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1071400005047 dimer interface [polypeptide binding]; other site 1071400005048 active site 1071400005049 CoA binding pocket [chemical binding]; other site 1071400005050 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1071400005051 MarR family; Region: MarR_2; pfam12802 1071400005052 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1071400005053 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1071400005054 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1071400005055 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1071400005056 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1071400005057 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1071400005058 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1071400005059 DNA binding residues [nucleotide binding] 1071400005060 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1071400005061 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1071400005062 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1071400005063 phosphopentomutase; Provisional; Region: PRK05362 1071400005064 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1071400005065 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1071400005066 intersubunit interface [polypeptide binding]; other site 1071400005067 active site 1071400005068 catalytic residue [active] 1071400005069 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1071400005070 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1071400005071 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1071400005072 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1071400005073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1071400005074 dimer interface [polypeptide binding]; other site 1071400005075 conserved gate region; other site 1071400005076 putative PBP binding loops; other site 1071400005077 ABC-ATPase subunit interface; other site 1071400005078 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1071400005079 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1071400005080 Walker A/P-loop; other site 1071400005081 ATP binding site [chemical binding]; other site 1071400005082 Q-loop/lid; other site 1071400005083 ABC transporter signature motif; other site 1071400005084 Walker B; other site 1071400005085 D-loop; other site 1071400005086 H-loop/switch region; other site 1071400005087 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1071400005088 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1071400005089 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1071400005090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1071400005091 S-adenosylmethionine binding site [chemical binding]; other site 1071400005092 putative lipid kinase; Reviewed; Region: PRK13055 1071400005093 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1071400005094 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1071400005095 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1071400005096 GatB domain; Region: GatB_Yqey; smart00845 1071400005097 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1071400005098 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1071400005099 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1071400005100 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1071400005101 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1071400005102 putative dimer interface [polypeptide binding]; other site 1071400005103 Repeat domain of CamS sex pheromone cAM373 precursor and related proteins; Region: CamS_repeat; cl17505 1071400005104 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1071400005105 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1071400005106 nucleotide binding pocket [chemical binding]; other site 1071400005107 K-X-D-G motif; other site 1071400005108 catalytic site [active] 1071400005109 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1071400005110 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1071400005111 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1071400005112 Dimer interface [polypeptide binding]; other site 1071400005113 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1071400005114 Part of AAA domain; Region: AAA_19; pfam13245 1071400005115 Family description; Region: UvrD_C_2; pfam13538 1071400005116 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1071400005117 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1071400005118 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1071400005119 active site 1071400005120 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1071400005121 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1071400005122 Predicted membrane protein [Function unknown]; Region: COG4684 1071400005123 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1071400005124 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1071400005125 23S rRNA interface [nucleotide binding]; other site 1071400005126 L3 interface [polypeptide binding]; other site 1071400005127 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1071400005128 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1071400005129 active site 1071400005130 dimerization interface 3.5A [polypeptide binding]; other site 1071400005131 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1071400005132 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1071400005133 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1071400005134 Walker A/P-loop; other site 1071400005135 ATP binding site [chemical binding]; other site 1071400005136 Q-loop/lid; other site 1071400005137 ABC transporter signature motif; other site 1071400005138 Walker B; other site 1071400005139 D-loop; other site 1071400005140 H-loop/switch region; other site 1071400005141 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1071400005142 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1071400005143 Walker A/P-loop; other site 1071400005144 ATP binding site [chemical binding]; other site 1071400005145 Q-loop/lid; other site 1071400005146 ABC transporter signature motif; other site 1071400005147 Walker B; other site 1071400005148 D-loop; other site 1071400005149 H-loop/switch region; other site 1071400005150 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1071400005151 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1071400005152 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1071400005153 alphaNTD homodimer interface [polypeptide binding]; other site 1071400005154 alphaNTD - beta interaction site [polypeptide binding]; other site 1071400005155 alphaNTD - beta' interaction site [polypeptide binding]; other site 1071400005156 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1071400005157 30S ribosomal protein S11; Validated; Region: PRK05309 1071400005158 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1071400005159 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1071400005160 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1071400005161 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1071400005162 rRNA binding site [nucleotide binding]; other site 1071400005163 predicted 30S ribosome binding site; other site 1071400005164 adenylate kinase; Reviewed; Region: adk; PRK00279 1071400005165 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1071400005166 AMP-binding site [chemical binding]; other site 1071400005167 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1071400005168 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1071400005169 SecY translocase; Region: SecY; pfam00344 1071400005170 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1071400005171 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1071400005172 23S rRNA binding site [nucleotide binding]; other site 1071400005173 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1071400005174 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1071400005175 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1071400005176 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1071400005177 23S rRNA interface [nucleotide binding]; other site 1071400005178 5S rRNA interface [nucleotide binding]; other site 1071400005179 L27 interface [polypeptide binding]; other site 1071400005180 L5 interface [polypeptide binding]; other site 1071400005181 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1071400005182 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1071400005183 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1071400005184 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1071400005185 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1071400005186 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1071400005187 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1071400005188 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1071400005189 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1071400005190 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1071400005191 RNA binding site [nucleotide binding]; other site 1071400005192 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1071400005193 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1071400005194 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1071400005195 23S rRNA interface [nucleotide binding]; other site 1071400005196 putative translocon interaction site; other site 1071400005197 signal recognition particle (SRP54) interaction site; other site 1071400005198 L23 interface [polypeptide binding]; other site 1071400005199 trigger factor interaction site; other site 1071400005200 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1071400005201 23S rRNA interface [nucleotide binding]; other site 1071400005202 5S rRNA interface [nucleotide binding]; other site 1071400005203 putative antibiotic binding site [chemical binding]; other site 1071400005204 L25 interface [polypeptide binding]; other site 1071400005205 L27 interface [polypeptide binding]; other site 1071400005206 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1071400005207 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1071400005208 G-X-X-G motif; other site 1071400005209 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1071400005210 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1071400005211 putative translocon binding site; other site 1071400005212 protein-rRNA interface [nucleotide binding]; other site 1071400005213 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1071400005214 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1071400005215 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1071400005216 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1071400005217 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1071400005218 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1071400005219 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1071400005220 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1071400005221 elongation factor G; Reviewed; Region: PRK12739 1071400005222 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1071400005223 G1 box; other site 1071400005224 putative GEF interaction site [polypeptide binding]; other site 1071400005225 GTP/Mg2+ binding site [chemical binding]; other site 1071400005226 Switch I region; other site 1071400005227 G2 box; other site 1071400005228 G3 box; other site 1071400005229 Switch II region; other site 1071400005230 G4 box; other site 1071400005231 G5 box; other site 1071400005232 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1071400005233 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1071400005234 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1071400005235 30S ribosomal protein S7; Validated; Region: PRK05302 1071400005236 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1071400005237 S17 interaction site [polypeptide binding]; other site 1071400005238 S8 interaction site; other site 1071400005239 16S rRNA interaction site [nucleotide binding]; other site 1071400005240 streptomycin interaction site [chemical binding]; other site 1071400005241 23S rRNA interaction site [nucleotide binding]; other site 1071400005242 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1071400005243 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1071400005244 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1071400005245 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1071400005246 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1071400005247 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1071400005248 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1071400005249 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1071400005250 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1071400005251 cleft; other site 1071400005252 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 1071400005253 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1071400005254 DNA binding site [nucleotide binding] 1071400005255 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1071400005256 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1071400005257 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1071400005258 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1071400005259 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1071400005260 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1071400005261 RPB1 interaction site [polypeptide binding]; other site 1071400005262 RPB10 interaction site [polypeptide binding]; other site 1071400005263 RPB11 interaction site [polypeptide binding]; other site 1071400005264 RPB3 interaction site [polypeptide binding]; other site 1071400005265 RPB12 interaction site [polypeptide binding]; other site 1071400005266 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1071400005267 Clp amino terminal domain; Region: Clp_N; pfam02861 1071400005268 Clp amino terminal domain; Region: Clp_N; pfam02861 1071400005269 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1071400005270 Walker A motif; other site 1071400005271 ATP binding site [chemical binding]; other site 1071400005272 Walker B motif; other site 1071400005273 arginine finger; other site 1071400005274 UvrB/uvrC motif; Region: UVR; pfam02151 1071400005275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1071400005276 Walker A motif; other site 1071400005277 ATP binding site [chemical binding]; other site 1071400005278 Walker B motif; other site 1071400005279 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1071400005280 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1071400005281 seryl-tRNA synthetase; Provisional; Region: PRK05431 1071400005282 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1071400005283 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1071400005284 dimer interface [polypeptide binding]; other site 1071400005285 active site 1071400005286 motif 1; other site 1071400005287 motif 2; other site 1071400005288 motif 3; other site 1071400005289 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1071400005290 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1071400005291 Substrate-binding site [chemical binding]; other site 1071400005292 Substrate specificity [chemical binding]; other site 1071400005293 Class I aldolases; Region: Aldolase_Class_I; cl17187 1071400005294 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 1071400005295 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1071400005296 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1071400005297 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1071400005298 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1071400005299 active site 1071400005300 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1071400005301 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 1071400005302 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1071400005303 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1071400005304 Predicted membrane protein [Function unknown]; Region: COG4709 1071400005305 Predicted transcriptional regulators [Transcription]; Region: COG1695 1071400005306 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1071400005307 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1071400005308 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1071400005309 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1071400005310 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1071400005311 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1071400005312 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1071400005313 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1071400005314 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1071400005315 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1071400005316 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1071400005317 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1071400005318 DNA binding residues [nucleotide binding] 1071400005319 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 1071400005320 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 1071400005321 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 1071400005322 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1071400005323 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1071400005324 non-specific DNA binding site [nucleotide binding]; other site 1071400005325 salt bridge; other site 1071400005326 sequence-specific DNA binding site [nucleotide binding]; other site 1071400005327 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1071400005328 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1071400005329 Coenzyme A binding pocket [chemical binding]; other site 1071400005330 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1071400005331 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1071400005332 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1071400005333 active site 1071400005334 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1071400005335 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1071400005336 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1071400005337 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1071400005338 hypothetical protein; Provisional; Region: PRK00967 1071400005339 chromosome segregation protein; Provisional; Region: PRK03918 1071400005340 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 1071400005341 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1071400005342 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1071400005343 inhibitor-cofactor binding pocket; inhibition site 1071400005344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1071400005345 catalytic residue [active] 1071400005346 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1071400005347 nucleotide binding site [chemical binding]; other site 1071400005348 N-acetyl-L-glutamate binding site [chemical binding]; other site 1071400005349 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1071400005350 heterotetramer interface [polypeptide binding]; other site 1071400005351 active site pocket [active] 1071400005352 cleavage site 1071400005353 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1071400005354 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1071400005355 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1071400005356 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1071400005357 homodimer interface [polypeptide binding]; other site 1071400005358 substrate-cofactor binding pocket; other site 1071400005359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1071400005360 catalytic residue [active] 1071400005361 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1071400005362 proposed active site lysine [active] 1071400005363 conserved cys residue [active] 1071400005364 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1071400005365 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1071400005366 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1071400005367 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1071400005368 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1071400005369 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1071400005370 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1071400005371 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1071400005372 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1071400005373 NAD(P) binding site [chemical binding]; other site 1071400005374 active site 1071400005375 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1071400005376 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1071400005377 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1071400005378 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1071400005379 DNA binding residues [nucleotide binding] 1071400005380 putative dimer interface [polypeptide binding]; other site 1071400005381 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1071400005382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1071400005383 active site 1071400005384 phosphorylation site [posttranslational modification] 1071400005385 intermolecular recognition site; other site 1071400005386 dimerization interface [polypeptide binding]; other site 1071400005387 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1071400005388 DNA binding site [nucleotide binding] 1071400005389 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1071400005390 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1071400005391 dimer interface [polypeptide binding]; other site 1071400005392 phosphorylation site [posttranslational modification] 1071400005393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1071400005394 ATP binding site [chemical binding]; other site 1071400005395 Mg2+ binding site [ion binding]; other site 1071400005396 G-X-G motif; other site 1071400005397 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1071400005398 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1071400005399 active site 1071400005400 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1071400005401 EamA-like transporter family; Region: EamA; pfam00892 1071400005402 EamA-like transporter family; Region: EamA; pfam00892 1071400005403 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1071400005404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1071400005405 S-adenosylmethionine binding site [chemical binding]; other site 1071400005406 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1071400005407 DNA binding residues [nucleotide binding] 1071400005408 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1071400005409 putative dimer interface [polypeptide binding]; other site 1071400005410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400005411 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400005412 putative substrate translocation pore; other site 1071400005413 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1071400005414 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1071400005415 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1071400005416 homodimer interface [polypeptide binding]; other site 1071400005417 catalytic residue [active] 1071400005418 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1071400005419 active site 1071400005420 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400005421 H+ Antiporter protein; Region: 2A0121; TIGR00900 1071400005422 putative substrate translocation pore; other site 1071400005423 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1071400005424 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1071400005425 catalytic Zn binding site [ion binding]; other site 1071400005426 NAD(P) binding site [chemical binding]; other site 1071400005427 structural Zn binding site [ion binding]; other site 1071400005428 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1071400005429 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1071400005430 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1071400005431 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1071400005432 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1071400005433 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1071400005434 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 1071400005435 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1071400005436 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1071400005437 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1071400005438 Coenzyme A binding pocket [chemical binding]; other site 1071400005439 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 1071400005440 active site 1071400005441 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1071400005442 Peptidase family M1; Region: Peptidase_M1; pfam01433 1071400005443 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1071400005444 Zn binding site [ion binding]; other site 1071400005445 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 1071400005446 short chain dehydrogenase; Validated; Region: PRK06182 1071400005447 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1071400005448 NADP binding site [chemical binding]; other site 1071400005449 active site 1071400005450 steroid binding site; other site 1071400005451 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1071400005452 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1071400005453 Predicted membrane protein [Function unknown]; Region: COG2364 1071400005454 Sugar transport protein; Region: Sugar_transport; pfam06800 1071400005455 Predicted membrane protein [Function unknown]; Region: COG1511 1071400005456 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1071400005457 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1071400005458 Predicted membrane protein [Function unknown]; Region: COG1511 1071400005459 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1071400005460 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1071400005461 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1071400005462 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1071400005463 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1071400005464 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1071400005465 GMP synthase; Reviewed; Region: guaA; PRK00074 1071400005466 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1071400005467 AMP/PPi binding site [chemical binding]; other site 1071400005468 candidate oxyanion hole; other site 1071400005469 catalytic triad [active] 1071400005470 potential glutamine specificity residues [chemical binding]; other site 1071400005471 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1071400005472 ATP Binding subdomain [chemical binding]; other site 1071400005473 Dimerization subdomain; other site 1071400005474 pantothenate kinase; Provisional; Region: PRK05439 1071400005475 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1071400005476 ATP-binding site [chemical binding]; other site 1071400005477 CoA-binding site [chemical binding]; other site 1071400005478 Mg2+-binding site [ion binding]; other site 1071400005479 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1071400005480 Part of AAA domain; Region: AAA_19; pfam13245 1071400005481 Family description; Region: UvrD_C_2; pfam13538 1071400005482 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1071400005483 catalytic core [active] 1071400005484 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1071400005485 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 1071400005486 metal binding site [ion binding]; metal-binding site 1071400005487 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1071400005488 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1071400005489 DNA binding residues [nucleotide binding] 1071400005490 putative dimer interface [polypeptide binding]; other site 1071400005491 maltose O-acetyltransferase; Provisional; Region: PRK10092 1071400005492 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1071400005493 active site 1071400005494 substrate binding site [chemical binding]; other site 1071400005495 trimer interface [polypeptide binding]; other site 1071400005496 CoA binding site [chemical binding]; other site 1071400005497 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1071400005498 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1071400005499 DNA binding residues [nucleotide binding] 1071400005500 putative dimer interface [polypeptide binding]; other site 1071400005501 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1071400005502 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1071400005503 Walker A/P-loop; other site 1071400005504 ATP binding site [chemical binding]; other site 1071400005505 Q-loop/lid; other site 1071400005506 ABC transporter signature motif; other site 1071400005507 Walker B; other site 1071400005508 D-loop; other site 1071400005509 H-loop/switch region; other site 1071400005510 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1071400005511 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1071400005512 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1071400005513 Walker A/P-loop; other site 1071400005514 ATP binding site [chemical binding]; other site 1071400005515 Q-loop/lid; other site 1071400005516 ABC transporter signature motif; other site 1071400005517 Walker B; other site 1071400005518 D-loop; other site 1071400005519 H-loop/switch region; other site 1071400005520 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1071400005521 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1071400005522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1071400005523 dimer interface [polypeptide binding]; other site 1071400005524 conserved gate region; other site 1071400005525 putative PBP binding loops; other site 1071400005526 ABC-ATPase subunit interface; other site 1071400005527 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1071400005528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1071400005529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1071400005530 dimer interface [polypeptide binding]; other site 1071400005531 ABC-ATPase subunit interface; other site 1071400005532 putative PBP binding loops; other site 1071400005533 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1071400005534 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1071400005535 peptide binding site [polypeptide binding]; other site 1071400005536 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1071400005537 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1071400005538 peptide binding site [polypeptide binding]; other site 1071400005539 GTPases [General function prediction only]; Region: HflX; COG2262 1071400005540 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1071400005541 HflX GTPase family; Region: HflX; cd01878 1071400005542 G1 box; other site 1071400005543 GTP/Mg2+ binding site [chemical binding]; other site 1071400005544 Switch I region; other site 1071400005545 G2 box; other site 1071400005546 G3 box; other site 1071400005547 Switch II region; other site 1071400005548 G4 box; other site 1071400005549 G5 box; other site 1071400005550 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1071400005551 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1071400005552 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1071400005553 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 1071400005554 putative NAD(P) binding site [chemical binding]; other site 1071400005555 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1071400005556 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1071400005557 DNA binding site [nucleotide binding] 1071400005558 domain linker motif; other site 1071400005559 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1071400005560 dimerization interface [polypeptide binding]; other site 1071400005561 ligand binding site [chemical binding]; other site 1071400005562 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 1071400005563 MgtC family; Region: MgtC; pfam02308 1071400005564 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1071400005565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1071400005566 dimer interface [polypeptide binding]; other site 1071400005567 conserved gate region; other site 1071400005568 putative PBP binding loops; other site 1071400005569 ABC-ATPase subunit interface; other site 1071400005570 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1071400005571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1071400005572 dimer interface [polypeptide binding]; other site 1071400005573 conserved gate region; other site 1071400005574 putative PBP binding loops; other site 1071400005575 ABC-ATPase subunit interface; other site 1071400005576 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1071400005577 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1071400005578 substrate binding pocket [chemical binding]; other site 1071400005579 membrane-bound complex binding site; other site 1071400005580 hinge residues; other site 1071400005581 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1071400005582 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1071400005583 Walker A/P-loop; other site 1071400005584 ATP binding site [chemical binding]; other site 1071400005585 Q-loop/lid; other site 1071400005586 ABC transporter signature motif; other site 1071400005587 Walker B; other site 1071400005588 D-loop; other site 1071400005589 H-loop/switch region; other site 1071400005590 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1071400005591 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1071400005592 catalytic triad [active] 1071400005593 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1071400005594 metal binding site 2 [ion binding]; metal-binding site 1071400005595 putative DNA binding helix; other site 1071400005596 metal binding site 1 [ion binding]; metal-binding site 1071400005597 dimer interface [polypeptide binding]; other site 1071400005598 structural Zn2+ binding site [ion binding]; other site 1071400005599 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1071400005600 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1071400005601 catalytic site [active] 1071400005602 G-X2-G-X-G-K; other site 1071400005603 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 1071400005604 active site 1071400005605 Ap4A binding cleft/pocket [chemical binding]; other site 1071400005606 P4 phosphate binding site; other site 1071400005607 nudix motif; other site 1071400005608 putative P2/P3 phosphate binding site [ion binding]; other site 1071400005609 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1071400005610 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1071400005611 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1071400005612 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1071400005613 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1071400005614 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1071400005615 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1071400005616 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1071400005617 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1071400005618 ligand binding site [chemical binding]; other site 1071400005619 homodimer interface [polypeptide binding]; other site 1071400005620 NAD(P) binding site [chemical binding]; other site 1071400005621 trimer interface B [polypeptide binding]; other site 1071400005622 trimer interface A [polypeptide binding]; other site 1071400005623 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1071400005624 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1071400005625 beta-D-glucuronidase; Provisional; Region: PRK10150 1071400005626 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1071400005627 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1071400005628 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1071400005629 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1071400005630 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1071400005631 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1071400005632 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 1071400005633 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696 1071400005634 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1071400005635 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1071400005636 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1071400005637 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1071400005638 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1071400005639 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1071400005640 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1071400005641 DNA binding site [nucleotide binding] 1071400005642 domain linker motif; other site 1071400005643 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1071400005644 dimerization interface [polypeptide binding]; other site 1071400005645 ligand binding site [chemical binding]; other site 1071400005646 sodium binding site [ion binding]; other site 1071400005647 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1071400005648 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1071400005649 Ca binding site [ion binding]; other site 1071400005650 active site 1071400005651 catalytic site [active] 1071400005652 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 1071400005653 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 1071400005654 active site 1071400005655 homodimer interface [polypeptide binding]; other site 1071400005656 catalytic site [active] 1071400005657 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1071400005658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400005659 putative substrate translocation pore; other site 1071400005660 hypothetical protein; Provisional; Region: PRK10621 1071400005661 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1071400005662 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1071400005663 galactonate dehydratase; Provisional; Region: PRK14017 1071400005664 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1071400005665 active site pocket [active] 1071400005666 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1071400005667 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1071400005668 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1071400005669 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1071400005670 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1071400005671 peptide binding site [polypeptide binding]; other site 1071400005672 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1071400005673 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1071400005674 Walker A/P-loop; other site 1071400005675 ATP binding site [chemical binding]; other site 1071400005676 Q-loop/lid; other site 1071400005677 ABC transporter signature motif; other site 1071400005678 Walker B; other site 1071400005679 D-loop; other site 1071400005680 H-loop/switch region; other site 1071400005681 ABC transporter; Region: ABC_tran_2; pfam12848 1071400005682 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1071400005683 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1071400005684 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1071400005685 active site 1071400005686 CAAX protease self-immunity; Region: Abi; pfam02517 1071400005687 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 1071400005688 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1071400005689 Uncharacterized conserved protein [Function unknown]; Region: COG3410 1071400005690 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1071400005691 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1071400005692 active site 1071400005693 galactoside permease; Reviewed; Region: lacY; PRK09528 1071400005694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400005695 putative substrate translocation pore; other site 1071400005696 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1071400005697 active site 1071400005698 Predicted transcriptional regulator [Transcription]; Region: COG4189 1071400005699 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1071400005700 putative DNA binding site [nucleotide binding]; other site 1071400005701 dimerization interface [polypeptide binding]; other site 1071400005702 putative Zn2+ binding site [ion binding]; other site 1071400005703 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1071400005704 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1071400005705 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1071400005706 active site 1071400005707 catalytic triad [active] 1071400005708 oxyanion hole [active] 1071400005709 CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd12218 1071400005710 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 1071400005711 tetramer interface [polypeptide binding]; other site 1071400005712 putative DNA binding site [nucleotide binding]; other site 1071400005713 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 1071400005714 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1071400005715 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1071400005716 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1071400005717 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1071400005718 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1071400005719 DNA binding residues [nucleotide binding] 1071400005720 putative dimer interface [polypeptide binding]; other site 1071400005721 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1071400005722 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 1071400005723 NADP binding site [chemical binding]; other site 1071400005724 putative substrate binding site [chemical binding]; other site 1071400005725 active site 1071400005726 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1071400005727 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1071400005728 zinc binding site [ion binding]; other site 1071400005729 putative ligand binding site [chemical binding]; other site 1071400005730 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1071400005731 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1071400005732 TM-ABC transporter signature motif; other site 1071400005733 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1071400005734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1071400005735 Walker A/P-loop; other site 1071400005736 ATP binding site [chemical binding]; other site 1071400005737 Q-loop/lid; other site 1071400005738 ABC transporter signature motif; other site 1071400005739 Walker B; other site 1071400005740 D-loop; other site 1071400005741 H-loop/switch region; other site 1071400005742 Predicted membrane protein [Function unknown]; Region: COG1288 1071400005743 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1071400005744 hypothetical protein; Provisional; Region: PRK07205 1071400005745 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1071400005746 active site 1071400005747 metal binding site [ion binding]; metal-binding site 1071400005748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400005749 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 1071400005750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400005751 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1071400005752 MarR family; Region: MarR; pfam01047 1071400005753 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1071400005754 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1071400005755 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1071400005756 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1071400005757 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1071400005758 FOG: CBS domain [General function prediction only]; Region: COG0517 1071400005759 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1071400005760 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1071400005761 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1071400005762 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1071400005763 Coenzyme A binding pocket [chemical binding]; other site 1071400005764 uracil transporter; Provisional; Region: PRK10720 1071400005765 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1071400005766 Coenzyme A binding pocket [chemical binding]; other site 1071400005767 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1071400005768 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1071400005769 substrate binding site [chemical binding]; other site 1071400005770 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1071400005771 Ligand Binding Site [chemical binding]; other site 1071400005772 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1071400005773 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1071400005774 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1071400005775 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1071400005776 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1071400005777 active site residue [active] 1071400005778 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 1071400005779 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1071400005780 hypothetical protein; Provisional; Region: PRK10621 1071400005781 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1071400005782 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1071400005783 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1071400005784 Walker A/P-loop; other site 1071400005785 ATP binding site [chemical binding]; other site 1071400005786 Q-loop/lid; other site 1071400005787 ABC transporter signature motif; other site 1071400005788 Walker B; other site 1071400005789 D-loop; other site 1071400005790 H-loop/switch region; other site 1071400005791 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1071400005792 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1071400005793 Walker A/P-loop; other site 1071400005794 ATP binding site [chemical binding]; other site 1071400005795 Q-loop/lid; other site 1071400005796 ABC transporter signature motif; other site 1071400005797 Walker B; other site 1071400005798 D-loop; other site 1071400005799 H-loop/switch region; other site 1071400005800 Cobalt transport protein; Region: CbiQ; cl00463 1071400005801 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1071400005802 NlpC/P60 family; Region: NLPC_P60; pfam00877 1071400005803 amino acid transporter; Region: 2A0306; TIGR00909 1071400005804 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1071400005805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400005806 putative substrate translocation pore; other site 1071400005807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400005808 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 1071400005809 Cadmium resistance transporter; Region: Cad; pfam03596 1071400005810 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1071400005811 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1071400005812 ATP binding site [chemical binding]; other site 1071400005813 putative Mg++ binding site [ion binding]; other site 1071400005814 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1071400005815 nucleotide binding region [chemical binding]; other site 1071400005816 ATP-binding site [chemical binding]; other site 1071400005817 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1071400005818 HRDC domain; Region: HRDC; pfam00570 1071400005819 Domain of unknown function (DUF389); Region: DUF389; pfam04087 1071400005820 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 1071400005821 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1071400005822 catalytic Zn binding site [ion binding]; other site 1071400005823 NAD binding site [chemical binding]; other site 1071400005824 structural Zn binding site [ion binding]; other site 1071400005825 flavodoxin; Provisional; Region: PRK06242 1071400005826 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 1071400005827 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1071400005828 PYR/PP interface [polypeptide binding]; other site 1071400005829 dimer interface [polypeptide binding]; other site 1071400005830 tetramer interface [polypeptide binding]; other site 1071400005831 TPP binding site [chemical binding]; other site 1071400005832 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1071400005833 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1071400005834 TPP-binding site [chemical binding]; other site 1071400005835 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1071400005836 active site 1071400005837 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1071400005838 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1071400005839 putative active site [active] 1071400005840 guanine deaminase; Region: guan_deamin; TIGR02967 1071400005841 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1071400005842 active site 1071400005843 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1071400005844 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1071400005845 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1071400005846 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1071400005847 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1071400005848 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1071400005849 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1071400005850 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1071400005851 metal binding site [ion binding]; metal-binding site 1071400005852 dimer interface [polypeptide binding]; other site 1071400005853 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1071400005854 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1071400005855 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1071400005856 non-specific DNA binding site [nucleotide binding]; other site 1071400005857 salt bridge; other site 1071400005858 sequence-specific DNA binding site [nucleotide binding]; other site 1071400005859 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1071400005860 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1071400005861 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1071400005862 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1071400005863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400005864 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400005865 putative substrate translocation pore; other site 1071400005866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1071400005867 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1071400005868 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1071400005869 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1071400005870 NAD(P) binding site [chemical binding]; other site 1071400005871 active site 1071400005872 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1071400005873 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1071400005874 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1071400005875 dimerization interface [polypeptide binding]; other site 1071400005876 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1071400005877 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1071400005878 NAD(P) binding site [chemical binding]; other site 1071400005879 active site 1071400005880 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1071400005881 catalytic core [active] 1071400005882 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1071400005883 substrate binding site [chemical binding]; other site 1071400005884 Mn binding site [ion binding]; other site 1071400005885 L-arabinose isomerase; Region: Arabinose_Isome; pfam02610 1071400005886 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1071400005887 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1071400005888 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1071400005889 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1071400005890 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1071400005891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400005892 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400005893 putative substrate translocation pore; other site 1071400005894 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1071400005895 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1071400005896 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1071400005897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1071400005898 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1071400005899 alpha-galactosidase; Region: PLN02808; cl17638 1071400005900 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1071400005901 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 1071400005902 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1071400005903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400005904 MFS/sugar transport protein; Region: MFS_2; pfam13347 1071400005905 putative substrate translocation pore; other site 1071400005906 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1071400005907 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1071400005908 Predicted transcriptional regulator [Transcription]; Region: COG4189 1071400005909 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1071400005910 dimerization interface [polypeptide binding]; other site 1071400005911 putative DNA binding site [nucleotide binding]; other site 1071400005912 putative Zn2+ binding site [ion binding]; other site 1071400005913 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1071400005914 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1071400005915 active site 1071400005916 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1071400005917 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1071400005918 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1071400005919 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1071400005920 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1071400005921 Walker A/P-loop; other site 1071400005922 ATP binding site [chemical binding]; other site 1071400005923 Q-loop/lid; other site 1071400005924 ABC transporter signature motif; other site 1071400005925 Walker B; other site 1071400005926 D-loop; other site 1071400005927 H-loop/switch region; other site 1071400005928 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1071400005929 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1071400005930 Walker A/P-loop; other site 1071400005931 ATP binding site [chemical binding]; other site 1071400005932 Q-loop/lid; other site 1071400005933 ABC transporter signature motif; other site 1071400005934 Walker B; other site 1071400005935 D-loop; other site 1071400005936 H-loop/switch region; other site 1071400005937 Cobalt transport protein; Region: CbiQ; cl00463 1071400005938 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1071400005939 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1071400005940 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1071400005941 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1071400005942 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1071400005943 active site 1071400005944 homotetramer interface [polypeptide binding]; other site 1071400005945 homodimer interface [polypeptide binding]; other site 1071400005946 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1071400005947 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1071400005948 Walker A/P-loop; other site 1071400005949 ATP binding site [chemical binding]; other site 1071400005950 Q-loop/lid; other site 1071400005951 ABC transporter signature motif; other site 1071400005952 Walker B; other site 1071400005953 D-loop; other site 1071400005954 H-loop/switch region; other site 1071400005955 TOBE domain; Region: TOBE_2; pfam08402 1071400005956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1071400005957 dimer interface [polypeptide binding]; other site 1071400005958 conserved gate region; other site 1071400005959 putative PBP binding loops; other site 1071400005960 ABC-ATPase subunit interface; other site 1071400005961 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1071400005962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1071400005963 dimer interface [polypeptide binding]; other site 1071400005964 conserved gate region; other site 1071400005965 putative PBP binding loops; other site 1071400005966 ABC-ATPase subunit interface; other site 1071400005967 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1071400005968 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1071400005969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400005970 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400005971 putative substrate translocation pore; other site 1071400005972 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1071400005973 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1071400005974 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1071400005975 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1071400005976 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1071400005977 motif II; other site 1071400005978 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1071400005979 putative phosphoketolase; Provisional; Region: PRK05261 1071400005980 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1071400005981 TPP-binding site; other site 1071400005982 XFP C-terminal domain; Region: XFP_C; pfam09363 1071400005983 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1071400005984 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1071400005985 active site 1071400005986 metal binding site [ion binding]; metal-binding site 1071400005987 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1071400005988 active site 1071400005989 metal binding site [ion binding]; metal-binding site 1071400005990 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1071400005991 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1071400005992 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1071400005993 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1071400005994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1071400005995 homodimer interface [polypeptide binding]; other site 1071400005996 catalytic residue [active] 1071400005997 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1071400005998 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1071400005999 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1071400006000 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1071400006001 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1071400006002 dimer interface [polypeptide binding]; other site 1071400006003 active site 1071400006004 catalytic residue [active] 1071400006005 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1071400006006 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1071400006007 metal binding site [ion binding]; metal-binding site 1071400006008 putative dimer interface [polypeptide binding]; other site 1071400006009 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1071400006010 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1071400006011 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1071400006012 active site 1071400006013 trimer interface [polypeptide binding]; other site 1071400006014 substrate binding site [chemical binding]; other site 1071400006015 CoA binding site [chemical binding]; other site 1071400006016 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1071400006017 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1071400006018 active site 1071400006019 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1071400006020 substrate binding site [chemical binding]; other site 1071400006021 catalytic residues [active] 1071400006022 dimer interface [polypeptide binding]; other site 1071400006023 aspartate kinase; Reviewed; Region: PRK09034 1071400006024 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1071400006025 putative catalytic residues [active] 1071400006026 putative nucleotide binding site [chemical binding]; other site 1071400006027 putative aspartate binding site [chemical binding]; other site 1071400006028 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1071400006029 allosteric regulatory residue; other site 1071400006030 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1071400006031 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1071400006032 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1071400006033 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1071400006034 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1071400006035 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1071400006036 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1071400006037 DEAD_2; Region: DEAD_2; pfam06733 1071400006038 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1071400006039 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1071400006040 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1071400006041 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1071400006042 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1071400006043 metal binding site 2 [ion binding]; metal-binding site 1071400006044 putative DNA binding helix; other site 1071400006045 metal binding site 1 [ion binding]; metal-binding site 1071400006046 dimer interface [polypeptide binding]; other site 1071400006047 structural Zn2+ binding site [ion binding]; other site 1071400006048 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1071400006049 amidase catalytic site [active] 1071400006050 Zn binding residues [ion binding]; other site 1071400006051 substrate binding site [chemical binding]; other site 1071400006052 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1071400006053 nucleotide binding site [chemical binding]; other site 1071400006054 homotetrameric interface [polypeptide binding]; other site 1071400006055 putative phosphate binding site [ion binding]; other site 1071400006056 putative allosteric binding site; other site 1071400006057 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1071400006058 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1071400006059 putative catalytic cysteine [active] 1071400006060 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1071400006061 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1071400006062 putative DNA binding site [nucleotide binding]; other site 1071400006063 putative Zn2+ binding site [ion binding]; other site 1071400006064 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1071400006065 active site residue [active] 1071400006066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1071400006067 dimer interface [polypeptide binding]; other site 1071400006068 conserved gate region; other site 1071400006069 ABC-ATPase subunit interface; other site 1071400006070 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1071400006071 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1071400006072 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1071400006073 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1071400006074 Walker A/P-loop; other site 1071400006075 ATP binding site [chemical binding]; other site 1071400006076 Q-loop/lid; other site 1071400006077 ABC transporter signature motif; other site 1071400006078 Walker B; other site 1071400006079 D-loop; other site 1071400006080 H-loop/switch region; other site 1071400006081 YibE/F-like protein; Region: YibE_F; pfam07907 1071400006082 YibE/F-like protein; Region: YibE_F; pfam07907 1071400006083 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1071400006084 Ligand Binding Site [chemical binding]; other site 1071400006085 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1071400006086 active site 2 [active] 1071400006087 active site 1 [active] 1071400006088 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1071400006089 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1071400006090 putative NAD(P) binding site [chemical binding]; other site 1071400006091 catalytic Zn binding site [ion binding]; other site 1071400006092 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1071400006093 dimerization interface [polypeptide binding]; other site 1071400006094 putative DNA binding site [nucleotide binding]; other site 1071400006095 putative Zn2+ binding site [ion binding]; other site 1071400006096 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1071400006097 Predicted membrane protein [Function unknown]; Region: COG4392 1071400006098 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1071400006099 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1071400006100 putative ADP-ribose binding site [chemical binding]; other site 1071400006101 putative active site [active] 1071400006102 recombination factor protein RarA; Reviewed; Region: PRK13342 1071400006103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1071400006104 Walker A motif; other site 1071400006105 ATP binding site [chemical binding]; other site 1071400006106 Walker B motif; other site 1071400006107 arginine finger; other site 1071400006108 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1071400006109 Predicted integral membrane protein [Function unknown]; Region: COG5617 1071400006110 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1071400006111 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1071400006112 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1071400006113 active site 1071400006114 Zn binding site [ion binding]; other site 1071400006115 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1071400006116 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1071400006117 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1071400006118 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1071400006119 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1071400006120 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1071400006121 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1071400006122 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1071400006123 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1071400006124 nucleotide binding site [chemical binding]; other site 1071400006125 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1071400006126 active site 1071400006127 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1071400006128 tetramer interfaces [polypeptide binding]; other site 1071400006129 binuclear metal-binding site [ion binding]; other site 1071400006130 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1071400006131 active site 1071400006132 DNA binding site [nucleotide binding] 1071400006133 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1071400006134 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1071400006135 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1071400006136 motif II; other site 1071400006137 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1071400006138 dimer interface [polypeptide binding]; other site 1071400006139 hypothetical protein; Provisional; Region: PRK04164 1071400006140 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1071400006141 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 1071400006142 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1071400006143 RNA/DNA hybrid binding site [nucleotide binding]; other site 1071400006144 active site 1071400006145 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1071400006146 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1071400006147 putative acyl-acceptor binding pocket; other site 1071400006148 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1071400006149 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1071400006150 Ligand binding site; other site 1071400006151 metal-binding site 1071400006152 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1071400006153 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1071400006154 putative acyl-acceptor binding pocket; other site 1071400006155 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1071400006156 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1071400006157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1071400006158 Walker A/P-loop; other site 1071400006159 ATP binding site [chemical binding]; other site 1071400006160 Q-loop/lid; other site 1071400006161 ABC transporter signature motif; other site 1071400006162 Walker B; other site 1071400006163 D-loop; other site 1071400006164 H-loop/switch region; other site 1071400006165 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1071400006166 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1071400006167 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1071400006168 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1071400006169 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1071400006170 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1071400006171 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1071400006172 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1071400006173 active site 1071400006174 cytosine deaminase; Provisional; Region: PRK09230 1071400006175 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1071400006176 active site 1071400006177 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1071400006178 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1071400006179 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1071400006180 TrkA-N domain; Region: TrkA_N; pfam02254 1071400006181 TrkA-C domain; Region: TrkA_C; pfam02080 1071400006182 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1071400006183 dimer interface [polypeptide binding]; other site 1071400006184 substrate binding site [chemical binding]; other site 1071400006185 ATP binding site [chemical binding]; other site 1071400006186 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1071400006187 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1071400006188 active site 1071400006189 catalytic tetrad [active] 1071400006190 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1071400006191 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1071400006192 OsmC-like protein; Region: OsmC; pfam02566 1071400006193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1071400006194 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1071400006195 Walker A motif; other site 1071400006196 ATP binding site [chemical binding]; other site 1071400006197 Walker B motif; other site 1071400006198 arginine finger; other site 1071400006199 UvrB/uvrC motif; Region: UVR; pfam02151 1071400006200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1071400006201 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1071400006202 Walker A motif; other site 1071400006203 ATP binding site [chemical binding]; other site 1071400006204 Walker B motif; other site 1071400006205 arginine finger; other site 1071400006206 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1071400006207 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1071400006208 DNA-binding site [nucleotide binding]; DNA binding site 1071400006209 RNA-binding motif; other site 1071400006210 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1071400006211 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1071400006212 dimer interface [polypeptide binding]; other site 1071400006213 FMN binding site [chemical binding]; other site 1071400006214 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1071400006215 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1071400006216 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1071400006217 HPr interaction site; other site 1071400006218 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1071400006219 active site 1071400006220 phosphorylation site [posttranslational modification] 1071400006221 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1071400006222 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1071400006223 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1071400006224 TraX protein; Region: TraX; cl05434 1071400006225 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1071400006226 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1071400006227 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1071400006228 Walker A/P-loop; other site 1071400006229 ATP binding site [chemical binding]; other site 1071400006230 Q-loop/lid; other site 1071400006231 ABC transporter signature motif; other site 1071400006232 Walker B; other site 1071400006233 D-loop; other site 1071400006234 H-loop/switch region; other site 1071400006235 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1071400006236 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1071400006237 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1071400006238 Walker A/P-loop; other site 1071400006239 ATP binding site [chemical binding]; other site 1071400006240 Q-loop/lid; other site 1071400006241 ABC transporter signature motif; other site 1071400006242 Walker B; other site 1071400006243 D-loop; other site 1071400006244 H-loop/switch region; other site 1071400006245 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 1071400006246 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1071400006247 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1071400006248 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1071400006249 PemK-like protein; Region: PemK; pfam02452 1071400006250 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1071400006251 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1071400006252 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1071400006253 NAD(P) binding site [chemical binding]; other site 1071400006254 active site 1071400006255 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1071400006256 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1071400006257 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1071400006258 dimerization interface [polypeptide binding]; other site 1071400006259 substrate binding pocket [chemical binding]; other site 1071400006260 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1071400006261 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 1071400006262 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1071400006263 active site 1071400006264 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1071400006265 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1071400006266 lipoyl attachment site [posttranslational modification]; other site 1071400006267 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 1071400006268 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1071400006269 NADP binding site [chemical binding]; other site 1071400006270 homodimer interface [polypeptide binding]; other site 1071400006271 active site 1071400006272 EDD domain protein, DegV family; Region: DegV; TIGR00762 1071400006273 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1071400006274 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 1071400006275 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1071400006276 DNA binding site [nucleotide binding] 1071400006277 domain linker motif; other site 1071400006278 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1071400006279 putative dimerization interface [polypeptide binding]; other site 1071400006280 putative ligand binding site [chemical binding]; other site 1071400006281 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1071400006282 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1071400006283 active site 1071400006284 substrate binding site [chemical binding]; other site 1071400006285 metal binding site [ion binding]; metal-binding site 1071400006286 CAAX protease self-immunity; Region: Abi; pfam02517 1071400006287 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1071400006288 active site 1071400006289 putative catalytic site [active] 1071400006290 DNA binding site [nucleotide binding] 1071400006291 putative phosphate binding site [ion binding]; other site 1071400006292 metal binding site A [ion binding]; metal-binding site 1071400006293 AP binding site [nucleotide binding]; other site 1071400006294 metal binding site B [ion binding]; metal-binding site 1071400006295 EDD domain protein, DegV family; Region: DegV; TIGR00762 1071400006296 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1071400006297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400006298 putative substrate translocation pore; other site 1071400006299 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400006300 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1071400006301 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1071400006302 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1071400006303 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1071400006304 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1071400006305 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1071400006306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1071400006307 Walker A/P-loop; other site 1071400006308 ATP binding site [chemical binding]; other site 1071400006309 Q-loop/lid; other site 1071400006310 ABC transporter signature motif; other site 1071400006311 Walker B; other site 1071400006312 D-loop; other site 1071400006313 H-loop/switch region; other site 1071400006314 ABC transporter; Region: ABC_tran_2; pfam12848 1071400006315 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1071400006316 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1071400006317 catalytic core [active] 1071400006318 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1071400006319 ZIP Zinc transporter; Region: Zip; pfam02535 1071400006320 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1071400006321 homopentamer interface [polypeptide binding]; other site 1071400006322 active site 1071400006323 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1071400006324 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1071400006325 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1071400006326 dimerization interface [polypeptide binding]; other site 1071400006327 active site 1071400006328 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1071400006329 Lumazine binding domain; Region: Lum_binding; pfam00677 1071400006330 Lumazine binding domain; Region: Lum_binding; pfam00677 1071400006331 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1071400006332 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1071400006333 catalytic motif [active] 1071400006334 Zn binding site [ion binding]; other site 1071400006335 RibD C-terminal domain; Region: RibD_C; cl17279 1071400006336 Putative amidase domain; Region: Amidase_6; pfam12671 1071400006337 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1071400006338 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1071400006339 active site 1071400006340 catalytic tetrad [active] 1071400006341 maltose O-acetyltransferase; Provisional; Region: PRK10092 1071400006342 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1071400006343 active site 1071400006344 substrate binding site [chemical binding]; other site 1071400006345 trimer interface [polypeptide binding]; other site 1071400006346 CoA binding site [chemical binding]; other site 1071400006347 L-arabinose isomerase; Provisional; Region: PRK02929 1071400006348 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1071400006349 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1071400006350 substrate binding site [chemical binding]; other site 1071400006351 trimer interface [polypeptide binding]; other site 1071400006352 Mn binding site [ion binding]; other site 1071400006353 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1071400006354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400006355 putative substrate translocation pore; other site 1071400006356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400006357 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1071400006358 DNA-binding site [nucleotide binding]; DNA binding site 1071400006359 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1071400006360 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1071400006361 putative dimerization interface [polypeptide binding]; other site 1071400006362 putative ligand binding site [chemical binding]; other site 1071400006363 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1071400006364 active site 1071400006365 catalytic residues [active] 1071400006366 Acetokinase family; Region: Acetate_kinase; cl17229 1071400006367 propionate/acetate kinase; Provisional; Region: PRK12379 1071400006368 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1071400006369 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1071400006370 N- and C-terminal domain interface [polypeptide binding]; other site 1071400006371 active site 1071400006372 catalytic site [active] 1071400006373 metal binding site [ion binding]; metal-binding site 1071400006374 carbohydrate binding site [chemical binding]; other site 1071400006375 ATP binding site [chemical binding]; other site 1071400006376 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_12; cd12177 1071400006377 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1071400006378 putative ligand binding site [chemical binding]; other site 1071400006379 putative NAD binding site [chemical binding]; other site 1071400006380 catalytic site [active] 1071400006381 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1071400006382 Glucuronate isomerase; Region: UxaC; pfam02614 1071400006383 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1071400006384 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1071400006385 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1071400006386 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1071400006387 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1071400006388 DNA-binding site [nucleotide binding]; DNA binding site 1071400006389 FCD domain; Region: FCD; pfam07729 1071400006390 PBP superfamily domain; Region: PBP_like_2; cl17296 1071400006391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400006392 putative substrate translocation pore; other site 1071400006393 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400006394 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 1071400006395 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1071400006396 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1071400006397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400006398 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1071400006399 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1071400006400 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1071400006401 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1071400006402 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1071400006403 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 1071400006404 active site 1071400006405 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1071400006406 NlpC/P60 family; Region: NLPC_P60; pfam00877 1071400006407 OsmC-like protein; Region: OsmC; cl00767 1071400006408 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400006409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400006410 amino acid transporter; Region: 2A0306; TIGR00909 1071400006411 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1071400006412 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1071400006413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1071400006414 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1071400006415 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1071400006416 putative NAD(P) binding site [chemical binding]; other site 1071400006417 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1071400006418 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1071400006419 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1071400006420 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1071400006421 Ligand Binding Site [chemical binding]; other site 1071400006422 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1071400006423 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1071400006424 active site 1071400006425 amidase; Provisional; Region: PRK06529 1071400006426 Amidase; Region: Amidase; cl11426 1071400006427 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 1071400006428 catalytic triad [active] 1071400006429 putative active site [active] 1071400006430 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 1071400006431 putative phosphoketolase; Provisional; Region: PRK05261 1071400006432 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1071400006433 TPP-binding site; other site 1071400006434 XFP C-terminal domain; Region: XFP_C; pfam09363 1071400006435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400006436 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400006437 putative substrate translocation pore; other site 1071400006438 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1071400006439 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1071400006440 DNA-binding site [nucleotide binding]; DNA binding site 1071400006441 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1071400006442 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1071400006443 putative deacylase active site [active] 1071400006444 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1071400006445 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1071400006446 Zn2+ binding site [ion binding]; other site 1071400006447 Mg2+ binding site [ion binding]; other site 1071400006448 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1071400006449 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1071400006450 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1071400006451 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1071400006452 putative catalytic cysteine [active] 1071400006453 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1071400006454 putative active site [active] 1071400006455 metal binding site [ion binding]; metal-binding site 1071400006456 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1071400006457 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1071400006458 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1071400006459 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1071400006460 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1071400006461 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1071400006462 active site 1071400006463 catalytic tetrad [active] 1071400006464 maltose O-acetyltransferase; Provisional; Region: PRK10092 1071400006465 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1071400006466 active site 1071400006467 substrate binding site [chemical binding]; other site 1071400006468 trimer interface [polypeptide binding]; other site 1071400006469 CoA binding site [chemical binding]; other site 1071400006470 Predicted permeases [General function prediction only]; Region: COG0679 1071400006471 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1071400006472 Domain of unknown function DUF21; Region: DUF21; pfam01595 1071400006473 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1071400006474 Transporter associated domain; Region: CorC_HlyC; smart01091 1071400006475 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1071400006476 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1071400006477 flavoprotein NrdI; Provisional; Region: PRK02551 1071400006478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400006479 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400006480 putative substrate translocation pore; other site 1071400006481 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 1071400006482 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1071400006483 active site 1071400006484 substrate binding site [chemical binding]; other site 1071400006485 trimer interface [polypeptide binding]; other site 1071400006486 CoA binding site [chemical binding]; other site 1071400006487 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1071400006488 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1071400006489 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1071400006490 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1071400006491 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1071400006492 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1071400006493 PemK-like protein; Region: PemK; cl00995 1071400006494 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1071400006495 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1071400006496 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1071400006497 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1071400006498 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1071400006499 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1071400006500 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1071400006501 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1071400006502 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1071400006503 Abi-like protein; Region: Abi_2; pfam07751 1071400006504 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1071400006505 peptidase domain interface [polypeptide binding]; other site 1071400006506 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 1071400006507 active site 1071400006508 catalytic triad [active] 1071400006509 calcium binding site [ion binding]; other site 1071400006510 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1071400006511 Isochorismatase family; Region: Isochorismatase; pfam00857 1071400006512 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1071400006513 catalytic triad [active] 1071400006514 conserved cis-peptide bond; other site 1071400006515 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1071400006516 thiamine phosphate binding site [chemical binding]; other site 1071400006517 active site 1071400006518 pyrophosphate binding site [ion binding]; other site 1071400006519 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1071400006520 thiS-thiF/thiG interaction site; other site 1071400006521 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 1071400006522 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 1071400006523 putative ATP binding site [chemical binding]; other site 1071400006524 putative substrate interface [chemical binding]; other site 1071400006525 thiazole synthase; Reviewed; Region: thiG; PRK00208 1071400006526 phosphate binding site [ion binding]; other site 1071400006527 allantoate amidohydrolase; Reviewed; Region: PRK09290 1071400006528 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1071400006529 active site 1071400006530 metal binding site [ion binding]; metal-binding site 1071400006531 dimer interface [polypeptide binding]; other site 1071400006532 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1071400006533 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1071400006534 multicopper oxidase; Provisional; Region: PRK10965 1071400006535 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1071400006536 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1071400006537 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1071400006538 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1071400006539 putative acyltransferase; Provisional; Region: PRK05790 1071400006540 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1071400006541 dimer interface [polypeptide binding]; other site 1071400006542 active site 1071400006543 CsbD-like; Region: CsbD; cl17424 1071400006544 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1071400006545 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1071400006546 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1071400006547 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1071400006548 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1071400006549 homodimer interface [polypeptide binding]; other site 1071400006550 substrate-cofactor binding pocket; other site 1071400006551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1071400006552 catalytic residue [active] 1071400006553 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1071400006554 Part of AAA domain; Region: AAA_19; pfam13245 1071400006555 Family description; Region: UvrD_C_2; pfam13538 1071400006556 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1071400006557 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1071400006558 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1071400006559 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1071400006560 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1071400006561 NAD(P) binding site [chemical binding]; other site 1071400006562 active site 1071400006563 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1071400006564 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1071400006565 active site 1071400006566 catalytic tetrad [active] 1071400006567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1071400006568 short chain dehydrogenase; Validated; Region: PRK07069 1071400006569 NAD(P) binding site [chemical binding]; other site 1071400006570 active site 1071400006571 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1071400006572 QueT transporter; Region: QueT; pfam06177 1071400006573 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1071400006574 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1071400006575 dimer interface [polypeptide binding]; other site 1071400006576 active site 1071400006577 metal binding site [ion binding]; metal-binding site 1071400006578 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1071400006579 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1071400006580 putative NAD(P) binding site [chemical binding]; other site 1071400006581 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1071400006582 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1071400006583 synthetase active site [active] 1071400006584 NTP binding site [chemical binding]; other site 1071400006585 metal binding site [ion binding]; metal-binding site 1071400006586 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1071400006587 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1071400006588 putative active site [active] 1071400006589 catalytic site [active] 1071400006590 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1071400006591 putative active site [active] 1071400006592 catalytic site [active] 1071400006593 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1071400006594 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1071400006595 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1071400006596 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 1071400006597 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1071400006598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400006599 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400006600 putative substrate translocation pore; other site 1071400006601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400006602 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400006603 putative substrate translocation pore; other site 1071400006604 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1071400006605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1071400006606 S-adenosylmethionine binding site [chemical binding]; other site 1071400006607 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1071400006608 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1071400006609 putative active site [active] 1071400006610 catalytic triad [active] 1071400006611 putative dimer interface [polypeptide binding]; other site 1071400006612 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 1071400006613 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1071400006614 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1071400006615 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1071400006616 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1071400006617 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1071400006618 active site 1071400006619 ribulose/triose binding site [chemical binding]; other site 1071400006620 phosphate binding site [ion binding]; other site 1071400006621 substrate (anthranilate) binding pocket [chemical binding]; other site 1071400006622 product (indole) binding pocket [chemical binding]; other site 1071400006623 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1071400006624 active site 1071400006625 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1071400006626 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1071400006627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1071400006628 catalytic residue [active] 1071400006629 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1071400006630 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1071400006631 substrate binding site [chemical binding]; other site 1071400006632 active site 1071400006633 catalytic residues [active] 1071400006634 heterodimer interface [polypeptide binding]; other site 1071400006635 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1071400006636 Predicted flavoprotein [General function prediction only]; Region: COG0431 1071400006637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1071400006638 non-specific DNA binding site [nucleotide binding]; other site 1071400006639 salt bridge; other site 1071400006640 sequence-specific DNA binding site [nucleotide binding]; other site 1071400006641 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1071400006642 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1071400006643 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1071400006644 non-specific DNA binding site [nucleotide binding]; other site 1071400006645 salt bridge; other site 1071400006646 sequence-specific DNA binding site [nucleotide binding]; other site 1071400006647 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1071400006648 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1071400006649 N-terminal domain interface [polypeptide binding]; other site 1071400006650 dimer interface [polypeptide binding]; other site 1071400006651 substrate binding pocket (H-site) [chemical binding]; other site 1071400006652 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1071400006653 peptidase domain interface [polypeptide binding]; other site 1071400006654 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 1071400006655 active site 1071400006656 catalytic triad [active] 1071400006657 calcium binding site [ion binding]; other site 1071400006658 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 1071400006659 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1071400006660 peptide binding site [polypeptide binding]; other site 1071400006661 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 1071400006662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1071400006663 dimer interface [polypeptide binding]; other site 1071400006664 conserved gate region; other site 1071400006665 putative PBP binding loops; other site 1071400006666 ABC-ATPase subunit interface; other site 1071400006667 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1071400006668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1071400006669 dimer interface [polypeptide binding]; other site 1071400006670 conserved gate region; other site 1071400006671 putative PBP binding loops; other site 1071400006672 ABC-ATPase subunit interface; other site 1071400006673 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1071400006674 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1071400006675 Walker A/P-loop; other site 1071400006676 ATP binding site [chemical binding]; other site 1071400006677 Q-loop/lid; other site 1071400006678 ABC transporter signature motif; other site 1071400006679 Walker B; other site 1071400006680 D-loop; other site 1071400006681 H-loop/switch region; other site 1071400006682 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1071400006683 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1071400006684 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1071400006685 Walker A/P-loop; other site 1071400006686 ATP binding site [chemical binding]; other site 1071400006687 Q-loop/lid; other site 1071400006688 ABC transporter signature motif; other site 1071400006689 Walker B; other site 1071400006690 D-loop; other site 1071400006691 H-loop/switch region; other site 1071400006692 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1071400006693 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1071400006694 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1071400006695 NAD binding site [chemical binding]; other site 1071400006696 substrate binding site [chemical binding]; other site 1071400006697 putative active site [active] 1071400006698 maltose phosphorylase; Provisional; Region: PRK13807 1071400006699 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1071400006700 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1071400006701 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1071400006702 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400006703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400006704 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1071400006705 ROK family; Region: ROK; pfam00480 1071400006706 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1071400006707 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 1071400006708 putative NAD(P) binding site [chemical binding]; other site 1071400006709 catalytic Zn binding site [ion binding]; other site 1071400006710 Predicted membrane protein [Function unknown]; Region: COG2364 1071400006711 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1071400006712 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1071400006713 active site 1071400006714 metal binding site [ion binding]; metal-binding site 1071400006715 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1071400006716 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1071400006717 active site 1071400006718 dimer interface [polypeptide binding]; other site 1071400006719 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1071400006720 dimer interface [polypeptide binding]; other site 1071400006721 active site 1071400006722 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1071400006723 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1071400006724 DNA binding site [nucleotide binding] 1071400006725 domain linker motif; other site 1071400006726 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1071400006727 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 1071400006728 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1071400006729 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1071400006730 putative active site [active] 1071400006731 catalytic site [active] 1071400006732 putative metal binding site [ion binding]; other site 1071400006733 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1071400006734 trimer interface [polypeptide binding]; other site 1071400006735 active site 1071400006736 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 1071400006737 hypothetical protein; Provisional; Region: PRK13690 1071400006738 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1071400006739 substrate binding site [chemical binding]; other site 1071400006740 ATP binding site [chemical binding]; other site 1071400006741 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1071400006742 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1071400006743 substrate binding site [chemical binding]; other site 1071400006744 THF binding site; other site 1071400006745 zinc-binding site [ion binding]; other site 1071400006746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400006747 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400006748 putative substrate translocation pore; other site 1071400006749 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1071400006750 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1071400006751 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1071400006752 catalytic residue [active] 1071400006753 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1071400006754 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1071400006755 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1071400006756 Walker A/P-loop; other site 1071400006757 ATP binding site [chemical binding]; other site 1071400006758 Q-loop/lid; other site 1071400006759 ABC transporter signature motif; other site 1071400006760 Walker B; other site 1071400006761 D-loop; other site 1071400006762 H-loop/switch region; other site 1071400006763 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1071400006764 Putative transcription activator [Transcription]; Region: TenA; COG0819 1071400006765 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1071400006766 active site 1071400006767 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 1071400006768 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1071400006769 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1071400006770 D-lactate dehydrogenase; Validated; Region: PRK08605 1071400006771 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1071400006772 homodimer interface [polypeptide binding]; other site 1071400006773 ligand binding site [chemical binding]; other site 1071400006774 NAD binding site [chemical binding]; other site 1071400006775 catalytic site [active] 1071400006776 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1071400006777 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1071400006778 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1071400006779 dimerization interface [polypeptide binding]; other site 1071400006780 malate dehydrogenase; Provisional; Region: PRK13529 1071400006781 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1071400006782 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1071400006783 NAD(P) binding site [chemical binding]; other site 1071400006784 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1071400006785 Class II fumarases; Region: Fumarase_classII; cd01362 1071400006786 active site 1071400006787 tetramer interface [polypeptide binding]; other site 1071400006788 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1071400006789 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1071400006790 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1071400006791 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1071400006792 non-specific DNA binding site [nucleotide binding]; other site 1071400006793 salt bridge; other site 1071400006794 sequence-specific DNA binding site [nucleotide binding]; other site 1071400006795 CAAX protease self-immunity; Region: Abi; pfam02517 1071400006796 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1071400006797 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1071400006798 Walker A/P-loop; other site 1071400006799 ATP binding site [chemical binding]; other site 1071400006800 Q-loop/lid; other site 1071400006801 ABC transporter signature motif; other site 1071400006802 Walker B; other site 1071400006803 D-loop; other site 1071400006804 H-loop/switch region; other site 1071400006805 Predicted transcriptional regulators [Transcription]; Region: COG1725 1071400006806 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1071400006807 DNA-binding site [nucleotide binding]; DNA binding site 1071400006808 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1071400006809 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1071400006810 Walker A/P-loop; other site 1071400006811 ATP binding site [chemical binding]; other site 1071400006812 Q-loop/lid; other site 1071400006813 ABC transporter signature motif; other site 1071400006814 Walker B; other site 1071400006815 D-loop; other site 1071400006816 H-loop/switch region; other site 1071400006817 Protein of unknown function (DUF2712); Region: DUF2712; pfam10916 1071400006818 Helix-turn-helix domain; Region: HTH_38; pfam13936 1071400006819 Winged helix-turn helix; Region: HTH_29; pfam13551 1071400006820 Homeodomain-like domain; Region: HTH_32; pfam13565 1071400006821 RecX family; Region: RecX; cl00936 1071400006822 Integrase core domain; Region: rve; pfam00665 1071400006823 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1071400006824 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1071400006825 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1071400006826 non-specific DNA binding site [nucleotide binding]; other site 1071400006827 salt bridge; other site 1071400006828 sequence-specific DNA binding site [nucleotide binding]; other site 1071400006829 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 1071400006830 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1071400006831 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1071400006832 Predicted transcriptional regulator [Transcription]; Region: COG3655 1071400006833 non-specific DNA binding site [nucleotide binding]; other site 1071400006834 salt bridge; other site 1071400006835 sequence-specific DNA binding site [nucleotide binding]; other site 1071400006836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400006837 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400006838 putative substrate translocation pore; other site 1071400006839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400006840 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1071400006841 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1071400006842 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1071400006843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1071400006844 homodimer interface [polypeptide binding]; other site 1071400006845 catalytic residue [active] 1071400006846 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1071400006847 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1071400006848 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1071400006849 Predicted acetyltransferase [General function prediction only]; Region: COG3153 1071400006850 Coenzyme A binding pocket [chemical binding]; other site 1071400006851 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 1071400006852 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1071400006853 gating phenylalanine in ion channel; other site 1071400006854 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1071400006855 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1071400006856 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1071400006857 dimerization interface [polypeptide binding]; other site 1071400006858 aspartate kinase; Reviewed; Region: PRK09034 1071400006859 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1071400006860 nucleotide binding site [chemical binding]; other site 1071400006861 substrate binding site [chemical binding]; other site 1071400006862 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1071400006863 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1071400006864 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 1071400006865 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1071400006866 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1071400006867 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1071400006868 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1071400006869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1071400006870 catalytic residue [active] 1071400006871 homoserine kinase; Provisional; Region: PRK01212 1071400006872 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1071400006873 hypothetical protein; Provisional; Region: PRK04435 1071400006874 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1071400006875 DNA-binding interface [nucleotide binding]; DNA binding site 1071400006876 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 1071400006877 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1071400006878 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1071400006879 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1071400006880 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1071400006881 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1071400006882 putative NAD(P) binding site [chemical binding]; other site 1071400006883 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1071400006884 Putative esterase; Region: Esterase; pfam00756 1071400006885 S-formylglutathione hydrolase; Region: PLN02442 1071400006886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 1071400006887 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1071400006888 HTH domain; Region: HTH_11; cl17392 1071400006889 amino acid transporter; Region: 2A0306; TIGR00909 1071400006890 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1071400006891 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 1071400006892 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1071400006893 inhibitor-cofactor binding pocket; inhibition site 1071400006894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1071400006895 catalytic residue [active] 1071400006896 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1071400006897 putative catalytic site [active] 1071400006898 putative metal binding site [ion binding]; other site 1071400006899 putative phosphate binding site [ion binding]; other site 1071400006900 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1071400006901 catalytic core [active] 1071400006902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400006903 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400006904 putative substrate translocation pore; other site 1071400006905 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1071400006906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1071400006907 Coenzyme A binding pocket [chemical binding]; other site 1071400006908 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1071400006909 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1071400006910 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1071400006911 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1071400006912 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1071400006913 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1071400006914 active site 1071400006915 pyruvate oxidase; Provisional; Region: PRK08611 1071400006916 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1071400006917 PYR/PP interface [polypeptide binding]; other site 1071400006918 dimer interface [polypeptide binding]; other site 1071400006919 tetramer interface [polypeptide binding]; other site 1071400006920 TPP binding site [chemical binding]; other site 1071400006921 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1071400006922 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1071400006923 TPP-binding site [chemical binding]; other site 1071400006924 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1071400006925 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1071400006926 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1071400006927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400006928 putative substrate translocation pore; other site 1071400006929 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1071400006930 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1071400006931 putative NAD(P) binding site [chemical binding]; other site 1071400006932 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1071400006933 PhoU domain; Region: PhoU; pfam01895 1071400006934 PhoU domain; Region: PhoU; pfam01895 1071400006935 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1071400006936 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1071400006937 Walker A/P-loop; other site 1071400006938 ATP binding site [chemical binding]; other site 1071400006939 Q-loop/lid; other site 1071400006940 ABC transporter signature motif; other site 1071400006941 Walker B; other site 1071400006942 D-loop; other site 1071400006943 H-loop/switch region; other site 1071400006944 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 1071400006945 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1071400006946 Walker A/P-loop; other site 1071400006947 ATP binding site [chemical binding]; other site 1071400006948 Q-loop/lid; other site 1071400006949 ABC transporter signature motif; other site 1071400006950 Walker B; other site 1071400006951 D-loop; other site 1071400006952 H-loop/switch region; other site 1071400006953 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1071400006954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1071400006955 dimer interface [polypeptide binding]; other site 1071400006956 conserved gate region; other site 1071400006957 putative PBP binding loops; other site 1071400006958 ABC-ATPase subunit interface; other site 1071400006959 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1071400006960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1071400006961 dimer interface [polypeptide binding]; other site 1071400006962 conserved gate region; other site 1071400006963 putative PBP binding loops; other site 1071400006964 ABC-ATPase subunit interface; other site 1071400006965 PBP superfamily domain; Region: PBP_like_2; cl17296 1071400006966 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1071400006967 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1071400006968 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1071400006969 DNA binding site [nucleotide binding] 1071400006970 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1071400006971 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1071400006972 active site 1071400006973 dimer interface [polypeptide binding]; other site 1071400006974 metal binding site [ion binding]; metal-binding site 1071400006975 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 1071400006976 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 1071400006977 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1071400006978 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1071400006979 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1071400006980 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1071400006981 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1071400006982 glutamine binding [chemical binding]; other site 1071400006983 catalytic triad [active] 1071400006984 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1071400006985 acetylornithine deacetylase; Validated; Region: PRK08596 1071400006986 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1071400006987 metal binding site [ion binding]; metal-binding site 1071400006988 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 1071400006989 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 1071400006990 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1071400006991 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1071400006992 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1071400006993 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1071400006994 Catalytic site [active] 1071400006995 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1071400006996 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1071400006997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400006998 putative substrate translocation pore; other site 1071400006999 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1071400007000 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1071400007001 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1071400007002 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1071400007003 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1071400007004 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1071400007005 G1 box; other site 1071400007006 GTP/Mg2+ binding site [chemical binding]; other site 1071400007007 Switch I region; other site 1071400007008 G2 box; other site 1071400007009 Switch II region; other site 1071400007010 G3 box; other site 1071400007011 G4 box; other site 1071400007012 G5 box; other site 1071400007013 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1071400007014 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1071400007015 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1071400007016 G-X-X-G motif; other site 1071400007017 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1071400007018 RxxxH motif; other site 1071400007019 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1071400007020 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1071400007021 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1071400007022 acetoin reductases; Region: 23BDH; TIGR02415 1071400007023 NAD(P) binding site [chemical binding]; other site 1071400007024 active site 1071400007025 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1071400007026 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1071400007027 putative NAD(P) binding site [chemical binding]; other site 1071400007028 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1071400007029 dimerization interface [polypeptide binding]; other site 1071400007030 putative DNA binding site [nucleotide binding]; other site 1071400007031 putative Zn2+ binding site [ion binding]; other site 1071400007032 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1071400007033 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1071400007034 potential catalytic triad [active] 1071400007035 conserved cys residue [active] 1071400007036 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1071400007037 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1071400007038 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1071400007039 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1071400007040 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1071400007041 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 1071400007042 RelB antitoxin; Region: RelB; cl01171 1071400007043 Zeta toxin; Region: Zeta_toxin; pfam06414 1071400007044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1071400007045 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 1071400007046 MobA/MobL family; Region: MobA_MobL; pfam03389 1071400007047 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 1071400007048 phosphate binding site [ion binding]; other site 1071400007049 domain II; other site 1071400007050 domain III; other site 1071400007051 nucleotide binding site [chemical binding]; other site 1071400007052 DNA binding groove [nucleotide binding] 1071400007053 catalytic site [active] 1071400007054 domain IV; other site 1071400007055 Alphavirus E1 glycoprotein; Region: Alpha_E1_glycop; pfam01589 1071400007056 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1071400007057 Helix-turn-helix domain; Region: HTH_38; pfam13936 1071400007058 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1071400007059 Integrase core domain; Region: rve; pfam00665 1071400007060 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1071400007061 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1071400007062 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1071400007063 Zn2+ binding site [ion binding]; other site 1071400007064 Mg2+ binding site [ion binding]; other site 1071400007065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400007066 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1071400007067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1071400007068 FRG domain; Region: FRG; pfam08867 1071400007069 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1071400007070 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1071400007071 catalytic residues [active] 1071400007072 catalytic nucleophile [active] 1071400007073 Presynaptic Site I dimer interface [polypeptide binding]; other site 1071400007074 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1071400007075 Synaptic Flat tetramer interface [polypeptide binding]; other site 1071400007076 Synaptic Site I dimer interface [polypeptide binding]; other site 1071400007077 DNA binding site [nucleotide binding] 1071400007078 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1071400007079 DNA-binding interface [nucleotide binding]; DNA binding site 1071400007080 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1071400007081 MULE transposase domain; Region: MULE; pfam10551 1071400007082 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1071400007083 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1071400007084 active site 1071400007085 tetramer interface; other site 1071400007086 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1071400007087 MULE transposase domain; Region: MULE; pfam10551 1071400007088 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1071400007089 Chain length determinant protein; Region: Wzz; cl15801 1071400007090 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1071400007091 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1071400007092 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1071400007093 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1071400007094 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 1071400007095 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1071400007096 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 1071400007097 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1071400007098 active site 1071400007099 Chain length determinant protein; Region: Wzz; cl15801 1071400007100 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1071400007101 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1071400007102 active site 1071400007103 MULE transposase domain; Region: MULE; pfam10551 1071400007104 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1071400007105 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 1071400007106 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1071400007107 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 1071400007108 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1071400007109 Transposase; Region: HTH_Tnp_1; pfam01527 1071400007110 putative transposase OrfB; Reviewed; Region: PHA02517 1071400007111 HTH-like domain; Region: HTH_21; pfam13276 1071400007112 Integrase core domain; Region: rve; pfam00665 1071400007113 Integrase core domain; Region: rve_3; pfam13683 1071400007114 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1071400007115 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1071400007116 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1071400007117 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1071400007118 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1071400007119 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1071400007120 catalytic residues [active] 1071400007121 catalytic nucleophile [active] 1071400007122 Presynaptic Site I dimer interface [polypeptide binding]; other site 1071400007123 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1071400007124 Synaptic Flat tetramer interface [polypeptide binding]; other site 1071400007125 Synaptic Site I dimer interface [polypeptide binding]; other site 1071400007126 DNA binding site [nucleotide binding] 1071400007127 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1071400007128 non-specific DNA interactions [nucleotide binding]; other site 1071400007129 DNA binding site [nucleotide binding] 1071400007130 sequence specific DNA binding site [nucleotide binding]; other site 1071400007131 putative cAMP binding site [chemical binding]; other site 1071400007132 Helix-turn-helix domain; Region: HTH_17; pfam12728 1071400007133 Helix-turn-helix domain; Region: HTH_38; pfam13936 1071400007134 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1071400007135 Integrase core domain; Region: rve; pfam00665 1071400007136 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1071400007137 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1071400007138 active site 1071400007139 dimer interface [polypeptide binding]; other site 1071400007140 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1071400007141 dimer interface [polypeptide binding]; other site 1071400007142 active site 1071400007143 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1071400007144 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1071400007145 active site 1071400007146 metal binding site [ion binding]; metal-binding site 1071400007147 Predicted membrane protein [Function unknown]; Region: COG2364 1071400007148 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 1071400007149 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1071400007150 putative NAD(P) binding site [chemical binding]; other site 1071400007151 catalytic Zn binding site [ion binding]; other site 1071400007152 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1071400007153 ROK family; Region: ROK; pfam00480 1071400007154 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1071400007155 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1071400007156 DNA binding site [nucleotide binding] 1071400007157 domain linker motif; other site 1071400007158 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1071400007159 dimerization interface [polypeptide binding]; other site 1071400007160 ligand binding site [chemical binding]; other site 1071400007161 sodium binding site [ion binding]; other site 1071400007162 Helix-turn-helix domain; Region: HTH_38; pfam13936 1071400007163 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1071400007164 Integrase core domain; Region: rve; pfam00665 1071400007165 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 1071400007166 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1071400007167 Integrase core domain; Region: rve; pfam00665 1071400007168 Integrase core domain; Region: rve_3; cl15866 1071400007169 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1071400007170 Integrase core domain; Region: rve; pfam00665 1071400007171 transposase/IS protein; Provisional; Region: PRK09183 1071400007172 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1071400007173 Walker A motif; other site 1071400007174 ATP binding site [chemical binding]; other site 1071400007175 Walker B motif; other site 1071400007176 arginine finger; other site 1071400007177 Helix-turn-helix domain; Region: HTH_38; pfam13936 1071400007178 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1071400007179 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1071400007180 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1071400007181 P-loop; other site 1071400007182 Magnesium ion binding site [ion binding]; other site 1071400007183 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1071400007184 Magnesium ion binding site [ion binding]; other site