-- dump date 20140619_122754 -- class Genbank::misc_feature -- table misc_feature_note -- id note 998820000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 998820000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 998820000003 Walker A motif; other site 998820000004 ATP binding site [chemical binding]; other site 998820000005 Walker B motif; other site 998820000006 arginine finger; other site 998820000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 998820000008 DnaA box-binding interface [nucleotide binding]; other site 998820000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 998820000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 998820000011 putative DNA binding surface [nucleotide binding]; other site 998820000012 dimer interface [polypeptide binding]; other site 998820000013 beta-clamp/clamp loader binding surface; other site 998820000014 beta-clamp/translesion DNA polymerase binding surface; other site 998820000015 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 998820000016 recombination protein F; Reviewed; Region: recF; PRK00064 998820000017 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 998820000018 Walker A/P-loop; other site 998820000019 ATP binding site [chemical binding]; other site 998820000020 Q-loop/lid; other site 998820000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820000022 ABC transporter signature motif; other site 998820000023 Walker B; other site 998820000024 D-loop; other site 998820000025 H-loop/switch region; other site 998820000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 998820000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 998820000028 Mg2+ binding site [ion binding]; other site 998820000029 G-X-G motif; other site 998820000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 998820000031 anchoring element; other site 998820000032 dimer interface [polypeptide binding]; other site 998820000033 ATP binding site [chemical binding]; other site 998820000034 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 998820000035 active site 998820000036 metal binding site [ion binding]; metal-binding site 998820000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 998820000038 DNA gyrase subunit A; Validated; Region: PRK05560 998820000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 998820000040 CAP-like domain; other site 998820000041 active site 998820000042 primary dimer interface [polypeptide binding]; other site 998820000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 998820000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 998820000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 998820000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 998820000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 998820000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 998820000049 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 998820000050 intersubunit interface [polypeptide binding]; other site 998820000051 active site 998820000052 catalytic residue [active] 998820000053 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 998820000054 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 998820000055 dimer interface [polypeptide binding]; other site 998820000056 ssDNA binding site [nucleotide binding]; other site 998820000057 tetramer (dimer of dimers) interface [polypeptide binding]; other site 998820000058 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 998820000059 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 998820000060 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 998820000061 dimer interface [polypeptide binding]; other site 998820000062 ssDNA binding site [nucleotide binding]; other site 998820000063 tetramer (dimer of dimers) interface [polypeptide binding]; other site 998820000064 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 998820000065 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 998820000066 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 998820000067 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 998820000068 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 998820000069 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 998820000070 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 998820000071 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 998820000072 CAAX protease self-immunity; Region: Abi; pfam02517 998820000073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 998820000074 Surface antigen [General function prediction only]; Region: COG3942 998820000075 CHAP domain; Region: CHAP; pfam05257 998820000076 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 998820000077 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 998820000078 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 998820000079 FtsX-like permease family; Region: FtsX; pfam02687 998820000080 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 998820000081 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 998820000082 Walker A/P-loop; other site 998820000083 ATP binding site [chemical binding]; other site 998820000084 Q-loop/lid; other site 998820000085 ABC transporter signature motif; other site 998820000086 Walker B; other site 998820000087 D-loop; other site 998820000088 H-loop/switch region; other site 998820000089 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 998820000090 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 998820000091 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820000092 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 998820000093 active site 998820000094 motif I; other site 998820000095 motif II; other site 998820000096 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 998820000097 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 998820000098 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 998820000099 active site 998820000100 hypothetical protein; Provisional; Region: PRK10621 998820000101 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 998820000102 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 998820000103 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 998820000104 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 998820000105 Cl binding site [ion binding]; other site 998820000106 oligomer interface [polypeptide binding]; other site 998820000107 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 998820000108 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 998820000109 manganese transport protein MntH; Reviewed; Region: PRK00701 998820000110 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 998820000111 Peptidase family C69; Region: Peptidase_C69; pfam03577 998820000112 Enterocin A Immunity; Region: EntA_Immun; pfam08951 998820000113 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 998820000114 Predicted membrane protein [Function unknown]; Region: COG4392 998820000115 CAAX protease self-immunity; Region: Abi; pfam02517 998820000116 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 998820000117 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 998820000118 active site 998820000119 intersubunit interface [polypeptide binding]; other site 998820000120 catalytic residue [active] 998820000121 Transposase domain (DUF772); Region: DUF772; pfam05598 998820000122 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 998820000123 Transcriptional regulators [Transcription]; Region: GntR; COG1802 998820000124 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 998820000125 DNA-binding site [nucleotide binding]; DNA binding site 998820000126 FCD domain; Region: FCD; pfam07729 998820000127 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 998820000128 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 998820000129 non-specific DNA binding site [nucleotide binding]; other site 998820000130 salt bridge; other site 998820000131 sequence-specific DNA binding site [nucleotide binding]; other site 998820000132 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 998820000133 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 998820000134 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 998820000135 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 998820000136 Walker A/P-loop; other site 998820000137 ATP binding site [chemical binding]; other site 998820000138 Q-loop/lid; other site 998820000139 ABC transporter signature motif; other site 998820000140 Walker B; other site 998820000141 D-loop; other site 998820000142 H-loop/switch region; other site 998820000143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820000144 Major Facilitator Superfamily; Region: MFS_1; pfam07690 998820000145 putative substrate translocation pore; other site 998820000146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820000147 Predicted membrane protein [General function prediction only]; Region: COG4194 998820000148 MMPL family; Region: MMPL; pfam03176 998820000149 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 998820000150 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 998820000151 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 998820000152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820000153 putative PBP binding loops; other site 998820000154 dimer interface [polypeptide binding]; other site 998820000155 ABC-ATPase subunit interface; other site 998820000156 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 998820000157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820000158 dimer interface [polypeptide binding]; other site 998820000159 conserved gate region; other site 998820000160 putative PBP binding loops; other site 998820000161 ABC-ATPase subunit interface; other site 998820000162 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 998820000163 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 998820000164 Walker A/P-loop; other site 998820000165 ATP binding site [chemical binding]; other site 998820000166 Q-loop/lid; other site 998820000167 ABC transporter signature motif; other site 998820000168 Walker B; other site 998820000169 D-loop; other site 998820000170 H-loop/switch region; other site 998820000171 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 998820000172 CAAX protease self-immunity; Region: Abi; pfam02517 998820000173 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 998820000174 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 998820000175 Soluble P-type ATPase [General function prediction only]; Region: COG4087 998820000176 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 998820000177 metal-binding site [ion binding] 998820000178 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 998820000179 dinuclear metal binding motif [ion binding]; other site 998820000180 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 998820000181 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 998820000182 ligand binding site [chemical binding]; other site 998820000183 flexible hinge region; other site 998820000184 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 998820000185 putative switch regulator; other site 998820000186 non-specific DNA interactions [nucleotide binding]; other site 998820000187 DNA binding site [nucleotide binding] 998820000188 sequence specific DNA binding site [nucleotide binding]; other site 998820000189 putative cAMP binding site [chemical binding]; other site 998820000190 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 998820000191 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 998820000192 substrate binding site [chemical binding]; other site 998820000193 active site 998820000194 catalytic residues [active] 998820000195 heterodimer interface [polypeptide binding]; other site 998820000196 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 998820000197 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 998820000198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 998820000199 catalytic residue [active] 998820000200 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 998820000201 active site 998820000202 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 998820000203 active site 998820000204 ribulose/triose binding site [chemical binding]; other site 998820000205 phosphate binding site [ion binding]; other site 998820000206 substrate (anthranilate) binding pocket [chemical binding]; other site 998820000207 product (indole) binding pocket [chemical binding]; other site 998820000208 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 998820000209 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 998820000210 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 998820000211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820000212 Major Facilitator Superfamily; Region: MFS_1; pfam07690 998820000213 putative substrate translocation pore; other site 998820000214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820000215 putative substrate translocation pore; other site 998820000216 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 998820000217 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 998820000218 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 998820000219 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 998820000220 Walker A/P-loop; other site 998820000221 ATP binding site [chemical binding]; other site 998820000222 Q-loop/lid; other site 998820000223 ABC transporter signature motif; other site 998820000224 Walker B; other site 998820000225 D-loop; other site 998820000226 H-loop/switch region; other site 998820000227 PemK-like protein; Region: PemK; pfam02452 998820000228 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 998820000229 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 998820000230 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 998820000231 active site 998820000232 dihydrodipicolinate reductase; Provisional; Region: PRK00048 998820000233 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 998820000234 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 998820000235 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 998820000236 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 998820000237 dimer interface [polypeptide binding]; other site 998820000238 active site 998820000239 catalytic residue [active] 998820000240 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 998820000241 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 998820000242 metal binding site [ion binding]; metal-binding site 998820000243 putative dimer interface [polypeptide binding]; other site 998820000244 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 998820000245 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 998820000246 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 998820000247 putative trimer interface [polypeptide binding]; other site 998820000248 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 998820000249 putative CoA binding site [chemical binding]; other site 998820000250 putative trimer interface [polypeptide binding]; other site 998820000251 putative CoA binding site [chemical binding]; other site 998820000252 diaminopimelate decarboxylase; Region: lysA; TIGR01048 998820000253 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 998820000254 active site 998820000255 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 998820000256 substrate binding site [chemical binding]; other site 998820000257 catalytic residues [active] 998820000258 dimer interface [polypeptide binding]; other site 998820000259 aspartate kinase; Reviewed; Region: PRK09034 998820000260 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 998820000261 putative catalytic residues [active] 998820000262 putative nucleotide binding site [chemical binding]; other site 998820000263 putative aspartate binding site [chemical binding]; other site 998820000264 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 998820000265 allosteric regulatory residue; other site 998820000266 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 998820000267 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 998820000268 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 998820000269 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 998820000270 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 998820000271 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 998820000272 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 998820000273 nudix motif; other site 998820000274 EamA-like transporter family; Region: EamA; cl17759 998820000275 PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417 998820000276 catalytic residues [active] 998820000277 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 998820000278 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 998820000279 DHH family; Region: DHH; pfam01368 998820000280 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 998820000281 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 998820000282 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 998820000283 replicative DNA helicase; Provisional; Region: PRK05748 998820000284 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 998820000285 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 998820000286 Walker A motif; other site 998820000287 ATP binding site [chemical binding]; other site 998820000288 Walker B motif; other site 998820000289 DNA binding loops [nucleotide binding] 998820000290 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 998820000291 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 998820000292 GDP-binding site [chemical binding]; other site 998820000293 ACT binding site; other site 998820000294 IMP binding site; other site 998820000295 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 998820000296 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 998820000297 Soluble P-type ATPase [General function prediction only]; Region: COG4087 998820000298 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 998820000299 dimerization interface [polypeptide binding]; other site 998820000300 putative DNA binding site [nucleotide binding]; other site 998820000301 putative Zn2+ binding site [ion binding]; other site 998820000302 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 998820000303 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 998820000304 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 998820000305 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 998820000306 Transcriptional regulator [Transcription]; Region: LysR; COG0583 998820000307 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 998820000308 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 998820000309 dimerization interface [polypeptide binding]; other site 998820000310 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 998820000311 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 998820000312 non-specific DNA binding site [nucleotide binding]; other site 998820000313 salt bridge; other site 998820000314 sequence-specific DNA binding site [nucleotide binding]; other site 998820000315 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 998820000316 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 998820000317 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 998820000318 Walker A/P-loop; other site 998820000319 ATP binding site [chemical binding]; other site 998820000320 Q-loop/lid; other site 998820000321 ABC transporter signature motif; other site 998820000322 Walker B; other site 998820000323 D-loop; other site 998820000324 H-loop/switch region; other site 998820000325 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 998820000326 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 998820000327 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 998820000328 ATP cone domain; Region: ATP-cone; pfam03477 998820000329 Class III ribonucleotide reductase; Region: RNR_III; cd01675 998820000330 effector binding site; other site 998820000331 active site 998820000332 Zn binding site [ion binding]; other site 998820000333 glycine loop; other site 998820000334 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 998820000335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 998820000336 non-specific DNA binding site [nucleotide binding]; other site 998820000337 salt bridge; other site 998820000338 sequence-specific DNA binding site [nucleotide binding]; other site 998820000339 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 998820000340 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 998820000341 active site 998820000342 metal binding site [ion binding]; metal-binding site 998820000343 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 998820000344 FAD binding domain; Region: FAD_binding_4; pfam01565 998820000345 Transposase domain (DUF772); Region: DUF772; pfam05598 998820000346 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 998820000347 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 998820000348 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 998820000349 active site 998820000350 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 998820000351 putative dimer interface [polypeptide binding]; other site 998820000352 catalytic triad [active] 998820000353 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 998820000354 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 998820000355 ATP-grasp domain; Region: ATP-grasp_4; cl17255 998820000356 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 998820000357 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 998820000358 DNA binding site [nucleotide binding] 998820000359 active site 998820000360 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 998820000361 D-lactate dehydrogenase; Validated; Region: PRK08605 998820000362 homodimer interface [polypeptide binding]; other site 998820000363 ligand binding site [chemical binding]; other site 998820000364 NAD binding site [chemical binding]; other site 998820000365 catalytic site [active] 998820000366 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 998820000367 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 998820000368 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 998820000369 NAD(P) binding site [chemical binding]; other site 998820000370 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 998820000371 Protein of unknown function (DUF1516); Region: DUF1516; pfam07457 998820000372 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 998820000373 DsrE/DsrF-like family; Region: DrsE; cl00672 998820000374 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 998820000375 Helix-turn-helix domain; Region: HTH_38; pfam13936 998820000376 Integrase core domain; Region: rve; pfam00665 998820000377 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 998820000378 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 998820000379 Zn binding site [ion binding]; other site 998820000380 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 998820000381 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 998820000382 WxL domain surface cell wall-binding; Region: WxL; pfam13731 998820000383 WxL domain surface cell wall-binding; Region: WxL; pfam13731 998820000384 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 998820000385 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 998820000386 Mga helix-turn-helix domain; Region: Mga; pfam05043 998820000387 Protein of unknown function (DUF805); Region: DUF805; pfam05656 998820000388 Protein of unknown function (DUF805); Region: DUF805; pfam05656 998820000389 recombination factor protein RarA; Reviewed; Region: PRK13342 998820000390 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 998820000391 Walker A motif; other site 998820000392 ATP binding site [chemical binding]; other site 998820000393 Walker B motif; other site 998820000394 arginine finger; other site 998820000395 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 998820000396 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 998820000397 propionate/acetate kinase; Provisional; Region: PRK12379 998820000398 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 998820000399 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 998820000400 active site 998820000401 metal binding site [ion binding]; metal-binding site 998820000402 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 998820000403 endonuclease III; Region: ENDO3c; smart00478 998820000404 minor groove reading motif; other site 998820000405 helix-hairpin-helix signature motif; other site 998820000406 substrate binding pocket [chemical binding]; other site 998820000407 active site 998820000408 Domain of unknown function DUF77; Region: DUF77; pfam01910 998820000409 Predicted membrane protein [Function unknown]; Region: COG1511 998820000410 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 998820000411 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 998820000412 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 998820000413 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 998820000414 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 998820000415 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 998820000416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820000417 Major Facilitator Superfamily; Region: MFS_1; pfam07690 998820000418 putative substrate translocation pore; other site 998820000419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820000420 putative phosphoketolase; Provisional; Region: PRK05261 998820000421 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 998820000422 TPP-binding site; other site 998820000423 XFP C-terminal domain; Region: XFP_C; pfam09363 998820000424 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 998820000425 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 998820000426 peptide binding site [polypeptide binding]; other site 998820000427 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 998820000428 nudix motif; other site 998820000429 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 998820000430 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 998820000431 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 998820000432 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 998820000433 Repair protein; Region: Repair_PSII; pfam04536 998820000434 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 998820000435 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 998820000436 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 998820000437 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 998820000438 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 998820000439 putative ligand binding site [chemical binding]; other site 998820000440 putative NAD binding site [chemical binding]; other site 998820000441 catalytic site [active] 998820000442 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 998820000443 Predicted membrane protein [Function unknown]; Region: COG2261 998820000444 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 998820000445 Asp23 family; Region: Asp23; pfam03780 998820000446 Asp23 family; Region: Asp23; pfam03780 998820000447 Protein of unknown function (DUF969); Region: DUF969; pfam06149 998820000448 Predicted membrane protein [Function unknown]; Region: COG3817 998820000449 Protein of unknown function (DUF979); Region: DUF979; pfam06166 998820000450 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 998820000451 putative substrate binding pocket [chemical binding]; other site 998820000452 AC domain interface; other site 998820000453 catalytic triad [active] 998820000454 AB domain interface; other site 998820000455 interchain disulfide; other site 998820000456 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 998820000457 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 998820000458 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 998820000459 catalytic triad [active] 998820000460 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 998820000461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 998820000462 S-adenosylmethionine binding site [chemical binding]; other site 998820000463 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 998820000464 ParB-like nuclease domain; Region: ParBc; pfam02195 998820000465 KorB domain; Region: KorB; pfam08535 998820000466 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 998820000467 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 998820000468 P-loop; other site 998820000469 Magnesium ion binding site [ion binding]; other site 998820000470 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 998820000471 Magnesium ion binding site [ion binding]; other site 998820000472 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 998820000473 ParB-like nuclease domain; Region: ParB; smart00470 998820000474 KorB domain; Region: KorB; pfam08535 998820000475 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 998820000476 GTP-binding protein YchF; Reviewed; Region: PRK09601 998820000477 YchF GTPase; Region: YchF; cd01900 998820000478 G1 box; other site 998820000479 GTP/Mg2+ binding site [chemical binding]; other site 998820000480 Switch I region; other site 998820000481 G2 box; other site 998820000482 Switch II region; other site 998820000483 G3 box; other site 998820000484 G4 box; other site 998820000485 G5 box; other site 998820000486 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 998820000487 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 998820000488 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 998820000489 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 998820000490 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 998820000491 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 998820000492 active site 998820000493 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 998820000494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 998820000495 active site 998820000496 phosphorylation site [posttranslational modification] 998820000497 intermolecular recognition site; other site 998820000498 dimerization interface [polypeptide binding]; other site 998820000499 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 998820000500 DNA binding site [nucleotide binding] 998820000501 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 998820000502 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 998820000503 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 998820000504 dimer interface [polypeptide binding]; other site 998820000505 phosphorylation site [posttranslational modification] 998820000506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 998820000507 ATP binding site [chemical binding]; other site 998820000508 Mg2+ binding site [ion binding]; other site 998820000509 G-X-G motif; other site 998820000510 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 998820000511 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 998820000512 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 998820000513 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 998820000514 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 998820000515 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 998820000516 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 998820000517 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 998820000518 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 998820000519 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 998820000520 aspartate racemase; Region: asp_race; TIGR00035 998820000521 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 998820000522 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 998820000523 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 998820000524 active site 998820000525 catalytic tetrad [active] 998820000526 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 998820000527 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 998820000528 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 998820000529 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 998820000530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820000531 putative substrate translocation pore; other site 998820000532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820000533 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 998820000534 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 998820000535 tetrameric interface [polypeptide binding]; other site 998820000536 NAD binding site [chemical binding]; other site 998820000537 catalytic residues [active] 998820000538 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 998820000539 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 998820000540 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 998820000541 substrate binding site [chemical binding]; other site 998820000542 ATP binding site [chemical binding]; other site 998820000543 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 998820000544 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 998820000545 PYR/PP interface [polypeptide binding]; other site 998820000546 dimer interface [polypeptide binding]; other site 998820000547 TPP binding site [chemical binding]; other site 998820000548 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 998820000549 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 998820000550 TPP-binding site; other site 998820000551 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 998820000552 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 998820000553 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 998820000554 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 998820000555 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 998820000556 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 998820000557 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 998820000558 Fructose-bisphosphate aldolase class-II; Region: F_bP_aldolase; pfam01116 998820000559 active site 998820000560 intersubunit interface [polypeptide binding]; other site 998820000561 zinc binding site [ion binding]; other site 998820000562 Na+ binding site [ion binding]; other site 998820000563 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 998820000564 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 998820000565 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 998820000566 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 998820000567 putative active site [active] 998820000568 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 998820000569 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 998820000570 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 998820000571 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 998820000572 N- and C-terminal domain interface [polypeptide binding]; other site 998820000573 active site 998820000574 catalytic site [active] 998820000575 metal binding site [ion binding]; metal-binding site 998820000576 carbohydrate binding site [chemical binding]; other site 998820000577 ATP binding site [chemical binding]; other site 998820000578 fructuronate transporter; Provisional; Region: PRK10034; cl15264 998820000579 Citrate transporter; Region: CitMHS; pfam03600 998820000580 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 998820000581 active site 998820000582 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 998820000583 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 998820000584 Probable Catalytic site; other site 998820000585 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 998820000586 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 998820000587 active site 998820000588 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 998820000589 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 998820000590 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 998820000591 active site 998820000592 SH3-like domain; Region: SH3_8; pfam13457 998820000593 SH3-like domain; Region: SH3_8; pfam13457 998820000594 SH3-like domain; Region: SH3_8; pfam13457 998820000595 SH3-like domain; Region: SH3_8; pfam13457 998820000596 SH3-like domain; Region: SH3_8; pfam13457 998820000597 SH3-like domain; Region: SH3_8; pfam13457 998820000598 SH3-like domain; Region: SH3_8; pfam13457 998820000599 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 998820000600 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 998820000601 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 998820000602 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 998820000603 active site 998820000604 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 998820000605 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 998820000606 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 998820000607 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 998820000608 putative PBP binding regions; other site 998820000609 ABC-ATPase subunit interface; other site 998820000610 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 998820000611 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 998820000612 active site 998820000613 metal binding site [ion binding]; metal-binding site 998820000614 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 998820000615 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 998820000616 oligoendopeptidase F; Region: pepF; TIGR00181 998820000617 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 998820000618 active site 998820000619 Zn binding site [ion binding]; other site 998820000620 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 998820000621 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 998820000622 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 998820000623 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 998820000624 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 998820000625 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 998820000626 active site 998820000627 Protein of unknown function (DUF975); Region: DUF975; cl10504 998820000628 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 998820000629 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 998820000630 Catalytic site [active] 998820000631 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 998820000632 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 998820000633 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 998820000634 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 998820000635 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 998820000636 ABC transporter; Region: ABC_tran_2; pfam12848 998820000637 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 998820000638 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 998820000639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 998820000640 S-adenosylmethionine binding site [chemical binding]; other site 998820000641 Domain of unknown function (DUF4323); Region: DUF4323; pfam14211 998820000642 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 998820000643 catalytic residues [active] 998820000644 Uncharacterized conserved protein [Function unknown]; Region: COG2966 998820000645 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 998820000646 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 998820000647 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 998820000648 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 998820000649 putative ligand binding site [chemical binding]; other site 998820000650 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 998820000651 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 998820000652 TM-ABC transporter signature motif; other site 998820000653 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 998820000654 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 998820000655 TM-ABC transporter signature motif; other site 998820000656 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 998820000657 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 998820000658 Walker A/P-loop; other site 998820000659 ATP binding site [chemical binding]; other site 998820000660 Q-loop/lid; other site 998820000661 ABC transporter signature motif; other site 998820000662 Walker B; other site 998820000663 D-loop; other site 998820000664 H-loop/switch region; other site 998820000665 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 998820000666 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 998820000667 Walker A/P-loop; other site 998820000668 ATP binding site [chemical binding]; other site 998820000669 Q-loop/lid; other site 998820000670 ABC transporter signature motif; other site 998820000671 Walker B; other site 998820000672 D-loop; other site 998820000673 H-loop/switch region; other site 998820000674 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 998820000675 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 998820000676 Class I aldolases; Region: Aldolase_Class_I; cl17187 998820000677 catalytic residue [active] 998820000678 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 998820000679 intersubunit interface [polypeptide binding]; other site 998820000680 active site 998820000681 catalytic residue [active] 998820000682 phosphopentomutase; Provisional; Region: PRK05362 998820000683 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 998820000684 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 998820000685 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 998820000686 NlpC/P60 family; Region: NLPC_P60; pfam00877 998820000687 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 998820000688 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 998820000689 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 998820000690 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 998820000691 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 998820000692 DEAD/DEAH box helicase; Region: DEAD; pfam00270 998820000693 DEAD_2; Region: DEAD_2; pfam06733 998820000694 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 998820000695 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 998820000696 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 998820000697 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 998820000698 active site 998820000699 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 998820000700 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 998820000701 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 998820000702 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 998820000703 DNA-binding site [nucleotide binding]; DNA binding site 998820000704 UTRA domain; Region: UTRA; pfam07702 998820000705 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 998820000706 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 998820000707 dimer interface [polypeptide binding]; other site 998820000708 active site 998820000709 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 998820000710 putative active site [active] 998820000711 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 998820000712 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 998820000713 active site 998820000714 dimer interface [polypeptide binding]; other site 998820000715 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 998820000716 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 998820000717 active site 998820000718 phosphorylation site [posttranslational modification] 998820000719 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 998820000720 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 998820000721 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 998820000722 active pocket/dimerization site; other site 998820000723 active site 998820000724 phosphorylation site [posttranslational modification] 998820000725 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 998820000726 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 998820000727 Transposase domain (DUF772); Region: DUF772; pfam05598 998820000728 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 998820000729 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 998820000730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 998820000731 homodimer interface [polypeptide binding]; other site 998820000732 catalytic residue [active] 998820000733 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 998820000734 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 998820000735 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 998820000736 active site 998820000737 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 998820000738 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 998820000739 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 998820000740 active site 998820000741 P-loop; other site 998820000742 phosphorylation site [posttranslational modification] 998820000743 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 998820000744 active site 998820000745 methionine cluster; other site 998820000746 phosphorylation site [posttranslational modification] 998820000747 metal binding site [ion binding]; metal-binding site 998820000748 exoaminopeptidase; Provisional; Region: PRK09961 998820000749 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 998820000750 oligomer interface [polypeptide binding]; other site 998820000751 active site 998820000752 metal binding site [ion binding]; metal-binding site 998820000753 HTH domain; Region: HTH_11; pfam08279 998820000754 PRD domain; Region: PRD; pfam00874 998820000755 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 998820000756 active site 998820000757 P-loop; other site 998820000758 phosphorylation site [posttranslational modification] 998820000759 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 998820000760 active site 998820000761 phosphorylation site [posttranslational modification] 998820000762 peptidase T; Region: peptidase-T; TIGR01882 998820000763 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 998820000764 metal binding site [ion binding]; metal-binding site 998820000765 dimer interface [polypeptide binding]; other site 998820000766 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 998820000767 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 998820000768 peptide binding site [polypeptide binding]; other site 998820000769 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 998820000770 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 998820000771 Coenzyme A binding pocket [chemical binding]; other site 998820000772 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 998820000773 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 998820000774 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 998820000775 Walker A/P-loop; other site 998820000776 ATP binding site [chemical binding]; other site 998820000777 Q-loop/lid; other site 998820000778 ABC transporter signature motif; other site 998820000779 Walker B; other site 998820000780 D-loop; other site 998820000781 H-loop/switch region; other site 998820000782 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 998820000783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820000784 Walker A/P-loop; other site 998820000785 ATP binding site [chemical binding]; other site 998820000786 Q-loop/lid; other site 998820000787 ABC transporter signature motif; other site 998820000788 Walker B; other site 998820000789 D-loop; other site 998820000790 H-loop/switch region; other site 998820000791 Cobalt transport protein; Region: CbiQ; cl00463 998820000792 Putative transcription activator [Transcription]; Region: TenA; COG0819 998820000793 Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952 998820000794 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 998820000795 substrate binding site [chemical binding]; other site 998820000796 multimerization interface [polypeptide binding]; other site 998820000797 ATP binding site [chemical binding]; other site 998820000798 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 998820000799 thiamine phosphate binding site [chemical binding]; other site 998820000800 active site 998820000801 pyrophosphate binding site [ion binding]; other site 998820000802 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 998820000803 dimer interface [polypeptide binding]; other site 998820000804 substrate binding site [chemical binding]; other site 998820000805 ATP binding site [chemical binding]; other site 998820000806 Amino acid permease; Region: AA_permease_2; pfam13520 998820000807 Transcriptional regulators [Transcription]; Region: PurR; COG1609 998820000808 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 998820000809 DNA binding site [nucleotide binding] 998820000810 domain linker motif; other site 998820000811 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 998820000812 ligand binding site [chemical binding]; other site 998820000813 dimerization interface [polypeptide binding]; other site 998820000814 D-ribose pyranase; Provisional; Region: PRK11797 998820000815 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 998820000816 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 998820000817 Walker A/P-loop; other site 998820000818 ATP binding site [chemical binding]; other site 998820000819 Q-loop/lid; other site 998820000820 ABC transporter signature motif; other site 998820000821 Walker B; other site 998820000822 D-loop; other site 998820000823 H-loop/switch region; other site 998820000824 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 998820000825 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 998820000826 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 998820000827 TM-ABC transporter signature motif; other site 998820000828 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 998820000829 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 998820000830 ligand binding site [chemical binding]; other site 998820000831 dimerization interface [polypeptide binding]; other site 998820000832 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 998820000833 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 998820000834 substrate binding site [chemical binding]; other site 998820000835 dimer interface [polypeptide binding]; other site 998820000836 ATP binding site [chemical binding]; other site 998820000837 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 998820000838 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 998820000839 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 998820000840 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 998820000841 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 998820000842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820000843 Major Facilitator Superfamily; Region: MFS_1; pfam07690 998820000844 putative substrate translocation pore; other site 998820000845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820000846 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 998820000847 MarR family; Region: MarR_2; pfam12802 998820000848 Rhomboid family; Region: Rhomboid; cl11446 998820000849 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 998820000850 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820000851 ABC transporter signature motif; other site 998820000852 Walker B; other site 998820000853 D-loop; other site 998820000854 H-loop/switch region; other site 998820000855 Transposase domain (DUF772); Region: DUF772; pfam05598 998820000856 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 998820000857 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820000858 Walker A/P-loop; other site 998820000859 ATP binding site [chemical binding]; other site 998820000860 Q-loop/lid; other site 998820000861 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 998820000862 L-aspartate oxidase; Provisional; Region: PRK06175 998820000863 Predicted oxidoreductase [General function prediction only]; Region: COG3573 998820000864 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 998820000865 Mga helix-turn-helix domain; Region: Mga; pfam05043 998820000866 PRD domain; Region: PRD; pfam00874 998820000867 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 998820000868 active site 998820000869 P-loop; other site 998820000870 phosphorylation site [posttranslational modification] 998820000871 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 998820000872 active site 998820000873 phosphorylation site [posttranslational modification] 998820000874 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 998820000875 active site 998820000876 P-loop; other site 998820000877 phosphorylation site [posttranslational modification] 998820000878 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 998820000879 Fructose-bisphosphate aldolase class-II; Region: F_bP_aldolase; pfam01116 998820000880 active site 998820000881 intersubunit interface [polypeptide binding]; other site 998820000882 zinc binding site [ion binding]; other site 998820000883 Na+ binding site [ion binding]; other site 998820000884 AAA domain; Region: AAA_17; cl17253 998820000885 AAA domain; Region: AAA_18; pfam13238 998820000886 Predicted transcriptional regulators [Transcription]; Region: COG1378 998820000887 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 998820000888 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 998820000889 C-terminal domain interface [polypeptide binding]; other site 998820000890 sugar binding site [chemical binding]; other site 998820000891 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 998820000892 ornithine cyclodeaminase; Validated; Region: PRK08618 998820000893 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 998820000894 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 998820000895 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 998820000896 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 998820000897 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 998820000898 Helix-turn-helix domain; Region: HTH_38; pfam13936 998820000899 Integrase core domain; Region: rve; pfam00665 998820000900 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 998820000901 conserved hypothetical protein; Region: TIGR02328 998820000902 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 998820000903 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 998820000904 Transcriptional regulators [Transcription]; Region: PurR; COG1609 998820000905 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 998820000906 DNA binding site [nucleotide binding] 998820000907 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 998820000908 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 998820000909 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 998820000910 Sulfatase; Region: Sulfatase; cl17466 998820000911 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 998820000912 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 998820000913 Helix-turn-helix domain; Region: HTH_38; pfam13936 998820000914 Integrase core domain; Region: rve; pfam00665 998820000915 Sulfatase; Region: Sulfatase; cl17466 998820000916 Uncharacterized conserved protein [Function unknown]; Region: COG1262 998820000917 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 998820000918 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 998820000919 anaerobic sulfatase-maturase; Provisional; Region: PRK13758 998820000920 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 998820000921 FeS/SAM binding site; other site 998820000922 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 998820000923 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 998820000924 active site 998820000925 tetramer interface [polypeptide binding]; other site 998820000926 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 998820000927 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 998820000928 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 998820000929 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 998820000930 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 998820000931 DNA-binding site [nucleotide binding]; DNA binding site 998820000932 Predicted esterase [General function prediction only]; Region: COG0627 998820000933 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 998820000934 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 998820000935 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 998820000936 active site 998820000937 phosphorylation site [posttranslational modification] 998820000938 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 998820000939 active pocket/dimerization site; other site 998820000940 active site 998820000941 phosphorylation site [posttranslational modification] 998820000942 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 998820000943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 998820000944 Walker A motif; other site 998820000945 ATP binding site [chemical binding]; other site 998820000946 Walker B motif; other site 998820000947 arginine finger; other site 998820000948 Transcriptional antiterminator [Transcription]; Region: COG3933 998820000949 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 998820000950 active pocket/dimerization site; other site 998820000951 active site 998820000952 phosphorylation site [posttranslational modification] 998820000953 PRD domain; Region: PRD; pfam00874 998820000954 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 998820000955 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 998820000956 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 998820000957 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 998820000958 HTH domain; Region: HTH_11; pfam08279 998820000959 Mga helix-turn-helix domain; Region: Mga; pfam05043 998820000960 PRD domain; Region: PRD; pfam00874 998820000961 PRD domain; Region: PRD; pfam00874 998820000962 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 998820000963 active site 998820000964 P-loop; other site 998820000965 phosphorylation site [posttranslational modification] 998820000966 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 998820000967 active site 998820000968 phosphorylation site [posttranslational modification] 998820000969 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 998820000970 intersubunit interface [polypeptide binding]; other site 998820000971 active site 998820000972 zinc binding site [ion binding]; other site 998820000973 Na+ binding site [ion binding]; other site 998820000974 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 998820000975 active site 998820000976 phosphorylation site [posttranslational modification] 998820000977 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 998820000978 active site 998820000979 P-loop; other site 998820000980 phosphorylation site [posttranslational modification] 998820000981 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 998820000982 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 998820000983 active site 998820000984 catalytic residues [active] 998820000985 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 998820000986 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 998820000987 N- and C-terminal domain interface [polypeptide binding]; other site 998820000988 D-xylulose kinase; Region: XylB; TIGR01312 998820000989 active site 998820000990 MgATP binding site [chemical binding]; other site 998820000991 catalytic site [active] 998820000992 metal binding site [ion binding]; metal-binding site 998820000993 xylulose binding site [chemical binding]; other site 998820000994 homodimer interface [polypeptide binding]; other site 998820000995 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 998820000996 Helix-turn-helix domain; Region: HTH_38; pfam13936 998820000997 Integrase core domain; Region: rve; pfam00665 998820000998 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 998820000999 active site 998820001000 phosphorylation site [posttranslational modification] 998820001001 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 998820001002 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 998820001003 active site 998820001004 P-loop; other site 998820001005 phosphorylation site [posttranslational modification] 998820001006 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 998820001007 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 998820001008 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 998820001009 pyridoxal 5'-phosphate binding site [chemical binding]; other site 998820001010 homodimer interface [polypeptide binding]; other site 998820001011 catalytic residue [active] 998820001012 putative frv operon regulatory protein; Provisional; Region: PRK09863 998820001013 HTH domain; Region: HTH_11; pfam08279 998820001014 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 998820001015 active site 998820001016 phosphorylation site [posttranslational modification] 998820001017 HTH domain; Region: HTH_11; pfam08279 998820001018 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 998820001019 PRD domain; Region: PRD; pfam00874 998820001020 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 998820001021 active site 998820001022 phosphorylation site [posttranslational modification] 998820001023 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 998820001024 intersubunit interface [polypeptide binding]; other site 998820001025 active site 998820001026 zinc binding site [ion binding]; other site 998820001027 Na+ binding site [ion binding]; other site 998820001028 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 998820001029 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 998820001030 active site 998820001031 phosphorylation site [posttranslational modification] 998820001032 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 998820001033 active site 998820001034 P-loop; other site 998820001035 phosphorylation site [posttranslational modification] 998820001036 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 998820001037 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 998820001038 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 998820001039 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 998820001040 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 998820001041 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 998820001042 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 998820001043 classical (c) SDRs; Region: SDR_c; cd05233 998820001044 NAD(P) binding site [chemical binding]; other site 998820001045 active site 998820001046 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 998820001047 active pocket/dimerization site; other site 998820001048 active site 998820001049 phosphorylation site [posttranslational modification] 998820001050 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 998820001051 active site 998820001052 phosphorylation site [posttranslational modification] 998820001053 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 998820001054 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 998820001055 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 998820001056 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 998820001057 DAK2 domain; Region: Dak2; pfam02734 998820001058 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 998820001059 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 998820001060 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 998820001061 active site 998820001062 dimer interface [polypeptide binding]; other site 998820001063 magnesium binding site [ion binding]; other site 998820001064 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 998820001065 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 998820001066 tetramer interface [polypeptide binding]; other site 998820001067 active site 998820001068 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 998820001069 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 998820001070 DNA-binding site [nucleotide binding]; DNA binding site 998820001071 UTRA domain; Region: UTRA; pfam07702 998820001072 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 998820001073 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 998820001074 putative NAD(P) binding site [chemical binding]; other site 998820001075 catalytic Zn binding site [ion binding]; other site 998820001076 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 998820001077 DNA binding residues [nucleotide binding] 998820001078 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 998820001079 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 998820001080 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 998820001081 classical (c) SDRs; Region: SDR_c; cd05233 998820001082 NAD(P) binding site [chemical binding]; other site 998820001083 active site 998820001084 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 998820001085 active pocket/dimerization site; other site 998820001086 active site 998820001087 phosphorylation site [posttranslational modification] 998820001088 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 998820001089 active site 998820001090 phosphorylation site [posttranslational modification] 998820001091 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 998820001092 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 998820001093 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 998820001094 intersubunit interface [polypeptide binding]; other site 998820001095 active site 998820001096 zinc binding site [ion binding]; other site 998820001097 Na+ binding site [ion binding]; other site 998820001098 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 998820001099 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 998820001100 transmembrane helices; other site 998820001101 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 998820001102 Transcriptional regulator [Transcription]; Region: LysR; COG0583 998820001103 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 998820001104 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 998820001105 dimerization interface [polypeptide binding]; other site 998820001106 Uncharacterized conserved protein [Function unknown]; Region: COG1912 998820001107 hypothetical protein; Provisional; Region: PRK13661 998820001108 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 998820001109 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 998820001110 Walker A/P-loop; other site 998820001111 ATP binding site [chemical binding]; other site 998820001112 Q-loop/lid; other site 998820001113 ABC transporter signature motif; other site 998820001114 Walker B; other site 998820001115 D-loop; other site 998820001116 H-loop/switch region; other site 998820001117 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 998820001118 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 998820001119 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 998820001120 Walker A/P-loop; other site 998820001121 ATP binding site [chemical binding]; other site 998820001122 Q-loop/lid; other site 998820001123 ABC transporter signature motif; other site 998820001124 Walker B; other site 998820001125 D-loop; other site 998820001126 H-loop/switch region; other site 998820001127 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 998820001128 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 998820001129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 998820001130 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 998820001131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 998820001132 Transcriptional antiterminator [Transcription]; Region: COG3933 998820001133 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 998820001134 active pocket/dimerization site; other site 998820001135 active site 998820001136 phosphorylation site [posttranslational modification] 998820001137 PRD domain; Region: PRD; pfam00874 998820001138 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 998820001139 active pocket/dimerization site; other site 998820001140 active site 998820001141 phosphorylation site [posttranslational modification] 998820001142 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 998820001143 active site 998820001144 phosphorylation site [posttranslational modification] 998820001145 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 998820001146 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 998820001147 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 998820001148 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820001149 motif II; other site 998820001150 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 998820001151 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 998820001152 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 998820001153 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 998820001154 active site 998820001155 dimer interface [polypeptide binding]; other site 998820001156 magnesium binding site [ion binding]; other site 998820001157 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 998820001158 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 998820001159 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 998820001160 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 998820001161 active site 998820001162 P-loop; other site 998820001163 phosphorylation site [posttranslational modification] 998820001164 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 998820001165 active site 998820001166 phosphorylation site [posttranslational modification] 998820001167 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 998820001168 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 998820001169 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 998820001170 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 998820001171 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 998820001172 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 998820001173 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820001174 Walker A/P-loop; other site 998820001175 ATP binding site [chemical binding]; other site 998820001176 Q-loop/lid; other site 998820001177 ABC transporter signature motif; other site 998820001178 Walker B; other site 998820001179 D-loop; other site 998820001180 H-loop/switch region; other site 998820001181 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 998820001182 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 998820001183 substrate binding pocket [chemical binding]; other site 998820001184 membrane-bound complex binding site; other site 998820001185 hinge residues; other site 998820001186 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 998820001187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820001188 dimer interface [polypeptide binding]; other site 998820001189 conserved gate region; other site 998820001190 putative PBP binding loops; other site 998820001191 ABC-ATPase subunit interface; other site 998820001192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820001193 dimer interface [polypeptide binding]; other site 998820001194 conserved gate region; other site 998820001195 putative PBP binding loops; other site 998820001196 ABC-ATPase subunit interface; other site 998820001197 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 998820001198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820001199 putative substrate translocation pore; other site 998820001200 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 998820001201 YvrJ protein family; Region: YvrJ; pfam12841 998820001202 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 998820001203 active site 998820001204 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 998820001205 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 998820001206 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 998820001207 classical (c) SDRs; Region: SDR_c; cd05233 998820001208 NAD(P) binding site [chemical binding]; other site 998820001209 active site 998820001210 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 998820001211 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 998820001212 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 998820001213 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 998820001214 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 998820001215 FtsX-like permease family; Region: FtsX; pfam02687 998820001216 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 998820001217 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 998820001218 Walker A/P-loop; other site 998820001219 ATP binding site [chemical binding]; other site 998820001220 Q-loop/lid; other site 998820001221 ABC transporter signature motif; other site 998820001222 Walker B; other site 998820001223 D-loop; other site 998820001224 H-loop/switch region; other site 998820001225 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 998820001226 active site 998820001227 phosphorylation site [posttranslational modification] 998820001228 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 998820001229 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 998820001230 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 998820001231 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 998820001232 putative active site [active] 998820001233 putative catalytic site [active] 998820001234 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 998820001235 active pocket/dimerization site; other site 998820001236 active site 998820001237 phosphorylation site [posttranslational modification] 998820001238 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 998820001239 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 998820001240 Ca binding site [ion binding]; other site 998820001241 active site 998820001242 catalytic site [active] 998820001243 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 998820001244 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820001245 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 998820001246 Walker A/P-loop; other site 998820001247 ATP binding site [chemical binding]; other site 998820001248 Q-loop/lid; other site 998820001249 ABC transporter signature motif; other site 998820001250 Walker B; other site 998820001251 D-loop; other site 998820001252 H-loop/switch region; other site 998820001253 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 998820001254 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 998820001255 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 998820001256 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 998820001257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820001258 Walker A/P-loop; other site 998820001259 ATP binding site [chemical binding]; other site 998820001260 Q-loop/lid; other site 998820001261 ABC transporter signature motif; other site 998820001262 Walker B; other site 998820001263 D-loop; other site 998820001264 H-loop/switch region; other site 998820001265 Predicted membrane protein [Function unknown]; Region: COG1511 998820001266 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 998820001267 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 998820001268 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 998820001269 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 998820001270 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 998820001271 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 998820001272 active site 998820001273 myosin-cross-reactive antigen; Provisional; Region: PRK13977 998820001274 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 998820001275 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 998820001276 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 998820001277 DAK2 domain; Region: Dak2; cl03685 998820001278 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 998820001279 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 998820001280 OsmC-like protein; Region: OsmC; cl00767 998820001281 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 998820001282 active site 998820001283 catalytic site [active] 998820001284 substrate binding site [chemical binding]; other site 998820001285 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 998820001286 dimerization interface [polypeptide binding]; other site 998820001287 putative DNA binding site [nucleotide binding]; other site 998820001288 putative Zn2+ binding site [ion binding]; other site 998820001289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820001290 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 998820001291 putative substrate translocation pore; other site 998820001292 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 998820001293 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 998820001294 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 998820001295 intersubunit interface [polypeptide binding]; other site 998820001296 active site 998820001297 zinc binding site [ion binding]; other site 998820001298 Na+ binding site [ion binding]; other site 998820001299 pyruvate oxidase; Provisional; Region: PRK08611 998820001300 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 998820001301 PYR/PP interface [polypeptide binding]; other site 998820001302 dimer interface [polypeptide binding]; other site 998820001303 tetramer interface [polypeptide binding]; other site 998820001304 TPP binding site [chemical binding]; other site 998820001305 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 998820001306 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 998820001307 TPP-binding site [chemical binding]; other site 998820001308 Beta-lactamase; Region: Beta-lactamase; pfam00144 998820001309 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 998820001310 Methyltransferase domain; Region: Methyltransf_31; pfam13847 998820001311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 998820001312 S-adenosylmethionine binding site [chemical binding]; other site 998820001313 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 998820001314 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 998820001315 catalytic triad [active] 998820001316 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 998820001317 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 998820001318 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 998820001319 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 998820001320 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 998820001321 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 998820001322 DNA binding residues [nucleotide binding] 998820001323 putative dimer interface [polypeptide binding]; other site 998820001324 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 998820001325 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 998820001326 active site 998820001327 catalytic tetrad [active] 998820001328 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 998820001329 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 998820001330 putative NAD(P) binding site [chemical binding]; other site 998820001331 dimer interface [polypeptide binding]; other site 998820001332 Predicted transcriptional regulators [Transcription]; Region: COG1733 998820001333 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 998820001334 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 998820001335 beta-galactosidase; Region: BGL; TIGR03356 998820001336 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 998820001337 active site 998820001338 methionine cluster; other site 998820001339 phosphorylation site [posttranslational modification] 998820001340 metal binding site [ion binding]; metal-binding site 998820001341 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 998820001342 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 998820001343 active site 998820001344 P-loop; other site 998820001345 phosphorylation site [posttranslational modification] 998820001346 HTH domain; Region: HTH_11; cl17392 998820001347 Mga helix-turn-helix domain; Region: Mga; pfam05043 998820001348 PRD domain; Region: PRD; pfam00874 998820001349 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 998820001350 active site 998820001351 phosphorylation site [posttranslational modification] 998820001352 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 998820001353 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 998820001354 catalytic residues [active] 998820001355 catalytic nucleophile [active] 998820001356 Presynaptic Site I dimer interface [polypeptide binding]; other site 998820001357 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 998820001358 Synaptic Flat tetramer interface [polypeptide binding]; other site 998820001359 Synaptic Site I dimer interface [polypeptide binding]; other site 998820001360 DNA binding site [nucleotide binding] 998820001361 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 998820001362 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 998820001363 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 998820001364 active site 998820001365 catalytic site [active] 998820001366 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 998820001367 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 998820001368 Walker A/P-loop; other site 998820001369 ATP binding site [chemical binding]; other site 998820001370 Q-loop/lid; other site 998820001371 ABC transporter signature motif; other site 998820001372 Walker B; other site 998820001373 D-loop; other site 998820001374 H-loop/switch region; other site 998820001375 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 998820001376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 998820001377 active site 998820001378 phosphorylation site [posttranslational modification] 998820001379 intermolecular recognition site; other site 998820001380 dimerization interface [polypeptide binding]; other site 998820001381 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 998820001382 DNA binding site [nucleotide binding] 998820001383 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 998820001384 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 998820001385 dimerization interface [polypeptide binding]; other site 998820001386 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 998820001387 dimer interface [polypeptide binding]; other site 998820001388 phosphorylation site [posttranslational modification] 998820001389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 998820001390 ATP binding site [chemical binding]; other site 998820001391 Mg2+ binding site [ion binding]; other site 998820001392 G-X-G motif; other site 998820001393 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820001394 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 998820001395 Walker A/P-loop; other site 998820001396 ATP binding site [chemical binding]; other site 998820001397 ABC transporter; Region: ABC_tran; pfam00005 998820001398 Q-loop/lid; other site 998820001399 ABC transporter signature motif; other site 998820001400 Walker B; other site 998820001401 D-loop; other site 998820001402 H-loop/switch region; other site 998820001403 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 998820001404 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 998820001405 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 998820001406 catalytic triad [active] 998820001407 putative active site [active] 998820001408 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 998820001409 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 998820001410 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 998820001411 catalytic triad [active] 998820001412 putative active site [active] 998820001413 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 998820001414 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 998820001415 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 998820001416 Zn binding site [ion binding]; other site 998820001417 inner membrane transporter YjeM; Provisional; Region: PRK15238 998820001418 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 998820001419 Transcriptional regulator [Transcription]; Region: LysR; COG0583 998820001420 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 998820001421 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 998820001422 putative dimerization interface [polypeptide binding]; other site 998820001423 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 998820001424 classical (c) SDRs; Region: SDR_c; cd05233 998820001425 NAD(P) binding site [chemical binding]; other site 998820001426 active site 998820001427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 998820001428 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 998820001429 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 998820001430 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 998820001431 shikimate binding site; other site 998820001432 NAD(P) binding site [chemical binding]; other site 998820001433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820001434 putative substrate translocation pore; other site 998820001435 Major Facilitator Superfamily; Region: MFS_1; pfam07690 998820001436 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 998820001437 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 998820001438 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 998820001439 shikimate binding site; other site 998820001440 NAD(P) binding site [chemical binding]; other site 998820001441 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 998820001442 proposed active site lysine [active] 998820001443 conserved cys residue [active] 998820001444 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 998820001445 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 998820001446 dimer interface [polypeptide binding]; other site 998820001447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 998820001448 catalytic residue [active] 998820001449 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 998820001450 Int/Topo IB signature motif; other site 998820001451 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 998820001452 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 998820001453 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 998820001454 non-specific DNA binding site [nucleotide binding]; other site 998820001455 salt bridge; other site 998820001456 sequence-specific DNA binding site [nucleotide binding]; other site 998820001457 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 998820001458 ORF6N domain; Region: ORF6N; pfam10543 998820001459 ORF6C domain; Region: ORF6C; pfam10552 998820001460 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 998820001461 Domain of unknown function (DUF771); Region: DUF771; pfam05595 998820001462 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 998820001463 Helix-turn-helix domain; Region: HTH_36; pfam13730 998820001464 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 998820001465 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 998820001466 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 998820001467 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 998820001468 Walker A motif; other site 998820001469 ATP binding site [chemical binding]; other site 998820001470 Walker B motif; other site 998820001471 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 998820001472 active site 998820001473 catalytic site [active] 998820001474 substrate binding site [chemical binding]; other site 998820001475 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 998820001476 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 998820001477 active site 998820001478 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 998820001479 Helix-turn-helix domain; Region: HTH_38; pfam13936 998820001480 Integrase core domain; Region: rve; pfam00665 998820001481 GcrA cell cycle regulator; Region: GcrA; cl11564 998820001482 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 998820001483 Transposase; Region: HTH_Tnp_1; pfam01527 998820001484 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 998820001485 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 998820001486 Homeodomain-like domain; Region: HTH_23; cl17451 998820001487 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 998820001488 Transposase; Region: HTH_Tnp_1; cl17663 998820001489 Helix-turn-helix domain; Region: HTH_28; pfam13518 998820001490 putative transposase OrfB; Reviewed; Region: PHA02517 998820001491 HTH-like domain; Region: HTH_21; pfam13276 998820001492 Integrase core domain; Region: rve; pfam00665 998820001493 Integrase core domain; Region: rve_3; pfam13683 998820001494 HTH-like domain; Region: HTH_21; pfam13276 998820001495 Integrase core domain; Region: rve; pfam00665 998820001496 Integrase core domain; Region: rve_3; cl15866 998820001497 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 998820001498 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 998820001499 generic binding surface II; other site 998820001500 generic binding surface I; other site 998820001501 AAA-like domain; Region: AAA_10; pfam12846 998820001502 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 998820001503 Walker A motif; other site 998820001504 ATP binding site [chemical binding]; other site 998820001505 Walker B motif; other site 998820001506 hypothetical protein; Provisional; Region: PRK12495 998820001507 AAA-like domain; Region: AAA_10; pfam12846 998820001508 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 998820001509 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 998820001510 NlpC/P60 family; Region: NLPC_P60; cl17555 998820001511 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 998820001512 catalytic residues [active] 998820001513 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 998820001514 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 998820001515 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 998820001516 Toprim-like; Region: Toprim_2; pfam13155 998820001517 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 998820001518 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 998820001519 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 998820001520 active site 998820001521 catalytic site [active] 998820001522 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 998820001523 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 998820001524 Cl- selectivity filter; other site 998820001525 Cl- binding residues [ion binding]; other site 998820001526 pore gating glutamate residue; other site 998820001527 dimer interface [polypeptide binding]; other site 998820001528 H+/Cl- coupling transport residue; other site 998820001529 TrkA-C domain; Region: TrkA_C; pfam02080 998820001530 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 998820001531 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 998820001532 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 998820001533 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 998820001534 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 998820001535 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 998820001536 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820001537 active site 998820001538 motif I; other site 998820001539 motif II; other site 998820001540 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 998820001541 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 998820001542 Integrase core domain; Region: rve; pfam00665 998820001543 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 998820001544 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 998820001545 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 998820001546 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 998820001547 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 998820001548 active site 998820001549 phosphorylation site [posttranslational modification] 998820001550 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 998820001551 active pocket/dimerization site; other site 998820001552 active site 998820001553 phosphorylation site [posttranslational modification] 998820001554 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 998820001555 intersubunit interface [polypeptide binding]; other site 998820001556 active site 998820001557 catalytic residue [active] 998820001558 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 998820001559 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 998820001560 DNA-binding site [nucleotide binding]; DNA binding site 998820001561 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 998820001562 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 998820001563 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 998820001564 catalytic residues [active] 998820001565 catalytic nucleophile [active] 998820001566 Presynaptic Site I dimer interface [polypeptide binding]; other site 998820001567 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 998820001568 Synaptic Flat tetramer interface [polypeptide binding]; other site 998820001569 Synaptic Site I dimer interface [polypeptide binding]; other site 998820001570 DNA binding site [nucleotide binding] 998820001571 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 998820001572 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 998820001573 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 998820001574 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 998820001575 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 998820001576 putative transposase OrfB; Reviewed; Region: PHA02517 998820001577 HTH-like domain; Region: HTH_21; pfam13276 998820001578 Integrase core domain; Region: rve; pfam00665 998820001579 Integrase core domain; Region: rve_3; pfam13683 998820001580 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 998820001581 Transposase; Region: HTH_Tnp_1; pfam01527 998820001582 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 998820001583 ApbE family; Region: ApbE; pfam02424 998820001584 Predicted flavoprotein [General function prediction only]; Region: COG0431 998820001585 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 998820001586 Predicted flavoprotein [General function prediction only]; Region: COG0431 998820001587 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 998820001588 PAS domain; Region: PAS_10; pfam13596 998820001589 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 998820001590 Transposase; Region: HTH_Tnp_1; pfam01527 998820001591 HTH-like domain; Region: HTH_21; pfam13276 998820001592 DDE domain; Region: DDE_Tnp_IS240; pfam13610 998820001593 Integrase core domain; Region: rve; pfam00665 998820001594 Integrase core domain; Region: rve_3; pfam13683 998820001595 D-lactate dehydrogenase; Provisional; Region: PRK11183 998820001596 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 998820001597 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 998820001598 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 998820001599 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 998820001600 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 998820001601 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 998820001602 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 998820001603 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 998820001604 transmembrane helices; other site 998820001605 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 998820001606 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 998820001607 Transposase; Region: HTH_Tnp_1; cl17663 998820001608 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 998820001609 active site 998820001610 Bacterial SH3 domain; Region: SH3_5; pfam08460 998820001611 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 998820001612 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 998820001613 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 998820001614 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 998820001615 homodimer interface [polypeptide binding]; other site 998820001616 substrate-cofactor binding pocket; other site 998820001617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 998820001618 catalytic residue [active] 998820001619 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 998820001620 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 998820001621 substrate binding pocket [chemical binding]; other site 998820001622 membrane-bound complex binding site; other site 998820001623 hinge residues; other site 998820001624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820001625 dimer interface [polypeptide binding]; other site 998820001626 conserved gate region; other site 998820001627 putative PBP binding loops; other site 998820001628 ABC-ATPase subunit interface; other site 998820001629 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 998820001630 WxL domain surface cell wall-binding; Region: WxL; pfam13731 998820001631 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 998820001632 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 998820001633 legume lectins; Region: lectin_L-type; cd01951 998820001634 homotetramer interaction site [polypeptide binding]; other site 998820001635 homodimer interaction site [polypeptide binding]; other site 998820001636 carbohydrate binding site [chemical binding]; other site 998820001637 metal binding site [ion binding]; metal-binding site 998820001638 WxL domain surface cell wall-binding; Region: WxL; pfam13731 998820001639 WxL domain surface cell wall-binding; Region: WxL; pfam13731 998820001640 WxL domain surface cell wall-binding; Region: WxL; pfam13731 998820001641 legume lectins; Region: lectin_L-type; cd01951 998820001642 homotetramer interaction site [polypeptide binding]; other site 998820001643 carbohydrate binding site [chemical binding]; other site 998820001644 metal binding site [ion binding]; metal-binding site 998820001645 WxL domain surface cell wall-binding; Region: WxL; pfam13731 998820001646 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 998820001647 EamA-like transporter family; Region: EamA; pfam00892 998820001648 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 998820001649 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 998820001650 Walker A/P-loop; other site 998820001651 ATP binding site [chemical binding]; other site 998820001652 Q-loop/lid; other site 998820001653 ABC transporter signature motif; other site 998820001654 Walker B; other site 998820001655 D-loop; other site 998820001656 H-loop/switch region; other site 998820001657 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 998820001658 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 998820001659 substrate binding site [chemical binding]; other site 998820001660 ATP binding site [chemical binding]; other site 998820001661 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 998820001662 FAD binding site [chemical binding]; other site 998820001663 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 998820001664 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 998820001665 THF binding site; other site 998820001666 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 998820001667 substrate binding site [chemical binding]; other site 998820001668 THF binding site; other site 998820001669 zinc-binding site [ion binding]; other site 998820001670 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 998820001671 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 998820001672 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820001673 Walker A/P-loop; other site 998820001674 ATP binding site [chemical binding]; other site 998820001675 Q-loop/lid; other site 998820001676 ABC transporter signature motif; other site 998820001677 Walker B; other site 998820001678 D-loop; other site 998820001679 H-loop/switch region; other site 998820001680 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 998820001681 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 998820001682 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 998820001683 Walker A/P-loop; other site 998820001684 ATP binding site [chemical binding]; other site 998820001685 Q-loop/lid; other site 998820001686 ABC transporter signature motif; other site 998820001687 Walker B; other site 998820001688 D-loop; other site 998820001689 H-loop/switch region; other site 998820001690 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 998820001691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820001692 putative substrate translocation pore; other site 998820001693 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 998820001694 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 998820001695 DNA-binding site [nucleotide binding]; DNA binding site 998820001696 UTRA domain; Region: UTRA; pfam07702 998820001697 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 998820001698 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 998820001699 Ca binding site [ion binding]; other site 998820001700 active site 998820001701 catalytic site [active] 998820001702 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 998820001703 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 998820001704 HPr interaction site; other site 998820001705 glycerol kinase (GK) interaction site [polypeptide binding]; other site 998820001706 active site 998820001707 phosphorylation site [posttranslational modification] 998820001708 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 998820001709 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 998820001710 active site turn [active] 998820001711 phosphorylation site [posttranslational modification] 998820001712 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 998820001713 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 998820001714 serine/threonine transporter SstT; Provisional; Region: PRK13628 998820001715 amino acid transporter; Region: 2A0306; TIGR00909 998820001716 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 998820001717 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 998820001718 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 998820001719 NAD binding site [chemical binding]; other site 998820001720 dimer interface [polypeptide binding]; other site 998820001721 tetramer (dimer of dimers) interface [polypeptide binding]; other site 998820001722 substrate binding site [chemical binding]; other site 998820001723 glutamate dehydrogenase; Provisional; Region: PRK09414 998820001724 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 998820001725 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 998820001726 NAD(P) binding site [chemical binding]; other site 998820001727 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 998820001728 DNA-binding site [nucleotide binding]; DNA binding site 998820001729 RNA-binding motif; other site 998820001730 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 998820001731 OsmC-like protein; Region: OsmC; pfam02566 998820001732 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 998820001733 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 998820001734 ABC transporter; Region: ABC_tran_2; pfam12848 998820001735 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 998820001736 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 998820001737 NADH(P)-binding; Region: NAD_binding_10; pfam13460 998820001738 NAD(P) binding site [chemical binding]; other site 998820001739 putative active site [active] 998820001740 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 998820001741 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 998820001742 active site 998820001743 catalytic tetrad [active] 998820001744 putative transport protein YifK; Provisional; Region: PRK10746 998820001745 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 998820001746 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 998820001747 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 998820001748 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 998820001749 LytTr DNA-binding domain; Region: LytTR; smart00850 998820001750 Predicted membrane protein [Function unknown]; Region: COG1511 998820001751 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 998820001752 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820001753 Walker A/P-loop; other site 998820001754 ATP binding site [chemical binding]; other site 998820001755 Q-loop/lid; other site 998820001756 ABC transporter signature motif; other site 998820001757 Walker B; other site 998820001758 D-loop; other site 998820001759 H-loop/switch region; other site 998820001760 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 998820001761 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 998820001762 active site 998820001763 zinc binding site [ion binding]; other site 998820001764 hypothetical protein; Provisional; Region: PRK00967 998820001765 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 998820001766 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 998820001767 putative NAD(P) binding site [chemical binding]; other site 998820001768 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 998820001769 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 998820001770 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 998820001771 MgtC family; Region: MgtC; pfam02308 998820001772 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 998820001773 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 998820001774 Rhomboid family; Region: Rhomboid; cl11446 998820001775 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 998820001776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820001777 Walker A/P-loop; other site 998820001778 ATP binding site [chemical binding]; other site 998820001779 ABC transporter signature motif; other site 998820001780 Walker B; other site 998820001781 D-loop; other site 998820001782 H-loop/switch region; other site 998820001783 ABC transporter; Region: ABC_tran_2; pfam12848 998820001784 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 998820001785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820001786 Walker A/P-loop; other site 998820001787 ATP binding site [chemical binding]; other site 998820001788 Q-loop/lid; other site 998820001789 ABC transporter signature motif; other site 998820001790 Walker B; other site 998820001791 D-loop; other site 998820001792 H-loop/switch region; other site 998820001793 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 998820001794 putative uracil binding site [chemical binding]; other site 998820001795 putative active site [active] 998820001796 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 998820001797 amphipathic channel; other site 998820001798 Asn-Pro-Ala signature motifs; other site 998820001799 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 998820001800 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 998820001801 glycerol kinase; Provisional; Region: glpK; PRK00047 998820001802 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 998820001803 N- and C-terminal domain interface [polypeptide binding]; other site 998820001804 active site 998820001805 MgATP binding site [chemical binding]; other site 998820001806 catalytic site [active] 998820001807 metal binding site [ion binding]; metal-binding site 998820001808 glycerol binding site [chemical binding]; other site 998820001809 homotetramer interface [polypeptide binding]; other site 998820001810 homodimer interface [polypeptide binding]; other site 998820001811 FBP binding site [chemical binding]; other site 998820001812 protein IIAGlc interface [polypeptide binding]; other site 998820001813 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 998820001814 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 998820001815 active site 998820001816 CAT RNA binding domain; Region: CAT_RBD; pfam03123 998820001817 transcriptional antiterminator BglG; Provisional; Region: PRK09772 998820001818 PRD domain; Region: PRD; pfam00874 998820001819 PRD domain; Region: PRD; pfam00874 998820001820 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 998820001821 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 998820001822 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 998820001823 active site 998820001824 P-loop; other site 998820001825 phosphorylation site [posttranslational modification] 998820001826 6-phospho-beta-galactosidase; Region: lacG; TIGR01233 998820001827 beta-galactosidase; Region: BGL; TIGR03356 998820001828 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 998820001829 methionine cluster; other site 998820001830 active site 998820001831 phosphorylation site [posttranslational modification] 998820001832 metal binding site [ion binding]; metal-binding site 998820001833 galactokinase; Provisional; Region: PRK05322 998820001834 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 998820001835 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 998820001836 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 998820001837 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 998820001838 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 998820001839 NAD binding site [chemical binding]; other site 998820001840 homodimer interface [polypeptide binding]; other site 998820001841 active site 998820001842 substrate binding site [chemical binding]; other site 998820001843 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 998820001844 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 998820001845 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 998820001846 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 998820001847 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 998820001848 DNA binding site [nucleotide binding] 998820001849 domain linker motif; other site 998820001850 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 998820001851 putative dimerization interface [polypeptide binding]; other site 998820001852 putative ligand binding site [chemical binding]; other site 998820001853 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 998820001854 active site 998820001855 catalytic residues [active] 998820001856 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 998820001857 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 998820001858 active site 998820001859 phosphorylation site [posttranslational modification] 998820001860 Phosphotransferase system, galactitol-specific IIB component [Carbohydrate transport and metabolism]; Region: SgaB; COG3414 998820001861 active site 998820001862 P-loop; other site 998820001863 phosphorylation site [posttranslational modification] 998820001864 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 998820001865 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 998820001866 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 998820001867 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 998820001868 putative substrate binding site [chemical binding]; other site 998820001869 putative ATP binding site [chemical binding]; other site 998820001870 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 998820001871 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 998820001872 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 998820001873 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 998820001874 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 998820001875 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 998820001876 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 998820001877 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820001878 motif II; other site 998820001879 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 998820001880 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 998820001881 active site 998820001882 metal binding site [ion binding]; metal-binding site 998820001883 DNA binding site [nucleotide binding] 998820001884 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 998820001885 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 998820001886 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 998820001887 Walker A/P-loop; other site 998820001888 ATP binding site [chemical binding]; other site 998820001889 Q-loop/lid; other site 998820001890 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820001891 ABC transporter signature motif; other site 998820001892 Walker B; other site 998820001893 D-loop; other site 998820001894 H-loop/switch region; other site 998820001895 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 998820001896 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 998820001897 putative dimer interface [polypeptide binding]; other site 998820001898 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 998820001899 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 998820001900 minor groove reading motif; other site 998820001901 helix-hairpin-helix signature motif; other site 998820001902 substrate binding pocket [chemical binding]; other site 998820001903 active site 998820001904 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 998820001905 DNA binding and oxoG recognition site [nucleotide binding] 998820001906 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 998820001907 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 998820001908 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 998820001909 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 998820001910 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 998820001911 dimer interface [polypeptide binding]; other site 998820001912 substrate binding site [chemical binding]; other site 998820001913 ATP binding site [chemical binding]; other site 998820001914 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 998820001915 NADH(P)-binding; Region: NAD_binding_10; pfam13460 998820001916 NAD binding site [chemical binding]; other site 998820001917 substrate binding site [chemical binding]; other site 998820001918 putative active site [active] 998820001919 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 998820001920 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 998820001921 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 998820001922 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 998820001923 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 998820001924 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 998820001925 zinc binding site [ion binding]; other site 998820001926 putative ligand binding site [chemical binding]; other site 998820001927 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 998820001928 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 998820001929 zinc binding site [ion binding]; other site 998820001930 putative ligand binding site [chemical binding]; other site 998820001931 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 998820001932 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 998820001933 TM-ABC transporter signature motif; other site 998820001934 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 998820001935 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820001936 Walker A/P-loop; other site 998820001937 ATP binding site [chemical binding]; other site 998820001938 Q-loop/lid; other site 998820001939 ABC transporter signature motif; other site 998820001940 Walker B; other site 998820001941 D-loop; other site 998820001942 H-loop/switch region; other site 998820001943 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 998820001944 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 998820001945 NADP binding site [chemical binding]; other site 998820001946 dimer interface [polypeptide binding]; other site 998820001947 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 998820001948 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 998820001949 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 998820001950 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 998820001951 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820001952 motif II; other site 998820001953 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 998820001954 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 998820001955 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 998820001956 Ligand binding site; other site 998820001957 Putative Catalytic site; other site 998820001958 DXD motif; other site 998820001959 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 998820001960 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 998820001961 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 998820001962 Predicted membrane protein [Function unknown]; Region: COG2246 998820001963 GtrA-like protein; Region: GtrA; pfam04138 998820001964 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 998820001965 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 998820001966 active site 998820001967 phosphorylation site [posttranslational modification] 998820001968 intermolecular recognition site; other site 998820001969 dimerization interface [polypeptide binding]; other site 998820001970 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 998820001971 DNA binding site [nucleotide binding] 998820001972 Di-sulfide bridge nucleocytoplasmic transport domain; Region: Brr6_like_C_C; cl12377 998820001973 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 998820001974 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 998820001975 dimer interface [polypeptide binding]; other site 998820001976 phosphorylation site [posttranslational modification] 998820001977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 998820001978 ATP binding site [chemical binding]; other site 998820001979 Mg2+ binding site [ion binding]; other site 998820001980 G-X-G motif; other site 998820001981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 998820001982 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 998820001983 hypothetical protein; Provisional; Region: PRK06194 998820001984 classical (c) SDRs; Region: SDR_c; cd05233 998820001985 NAD(P) binding site [chemical binding]; other site 998820001986 active site 998820001987 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 998820001988 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 998820001989 dimer interface [polypeptide binding]; other site 998820001990 FMN binding site [chemical binding]; other site 998820001991 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 998820001992 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 998820001993 phosphate binding site [ion binding]; other site 998820001994 Predicted transcriptional regulators [Transcription]; Region: COG1695 998820001995 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 998820001996 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 998820001997 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 998820001998 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 998820001999 putative NAD(P) binding site [chemical binding]; other site 998820002000 dimer interface [polypeptide binding]; other site 998820002001 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 998820002002 Domain of unknown function DUF20; Region: UPF0118; pfam01594 998820002003 LexA repressor; Validated; Region: PRK00215 998820002004 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 998820002005 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 998820002006 Catalytic site [active] 998820002007 Membrane transport protein; Region: Mem_trans; pfam03547 998820002008 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 998820002009 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 998820002010 Uncharacterized conserved protein [Function unknown]; Region: COG3189 998820002011 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 998820002012 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 998820002013 Cl binding site [ion binding]; other site 998820002014 oligomer interface [polypeptide binding]; other site 998820002015 Transcriptional regulator [Transcription]; Region: LysR; COG0583 998820002016 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 998820002017 The substrate binding domain of LysR-type transcriptional regulator MleR which required for malolactic fermentation, contains type 2 periplasmic binidning fold; Region: PBP2_MleR; cd08437 998820002018 putative dimerization interface [polypeptide binding]; other site 998820002019 malate dehydrogenase; Provisional; Region: PRK13529 998820002020 Malic enzyme, N-terminal domain; Region: malic; pfam00390 998820002021 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 998820002022 NAD(P) binding site [chemical binding]; other site 998820002023 Membrane transport protein; Region: Mem_trans; pfam03547 998820002024 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 998820002025 dimer interface [polypeptide binding]; other site 998820002026 catalytic triad [active] 998820002027 peroxidatic and resolving cysteines [active] 998820002028 Flavodoxin domain; Region: Flavodoxin_5; cl17428 998820002029 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 998820002030 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 998820002031 non-specific DNA binding site [nucleotide binding]; other site 998820002032 salt bridge; other site 998820002033 sequence-specific DNA binding site [nucleotide binding]; other site 998820002034 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 998820002035 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 998820002036 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 998820002037 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 998820002038 Walker A/P-loop; other site 998820002039 ATP binding site [chemical binding]; other site 998820002040 Q-loop/lid; other site 998820002041 ABC transporter signature motif; other site 998820002042 Walker B; other site 998820002043 D-loop; other site 998820002044 H-loop/switch region; other site 998820002045 oligoendopeptidase F; Region: pepF; TIGR00181 998820002046 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 998820002047 active site 998820002048 Zn binding site [ion binding]; other site 998820002049 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 998820002050 glucose-1-dehydrogenase; Provisional; Region: PRK06947 998820002051 NAD(P) binding site [chemical binding]; other site 998820002052 active site 998820002053 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 998820002054 active site 998820002055 multimer interface [polypeptide binding]; other site 998820002056 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 998820002057 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 998820002058 Soluble P-type ATPase [General function prediction only]; Region: COG4087 998820002059 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 998820002060 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 998820002061 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 998820002062 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 998820002063 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 998820002064 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820002065 motif II; other site 998820002066 Transcriptional regulators [Transcription]; Region: MarR; COG1846 998820002067 MarR family; Region: MarR_2; pfam12802 998820002068 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 998820002069 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 998820002070 flavoprotein NrdI; Provisional; Region: PRK02551 998820002071 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 998820002072 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 998820002073 active site 998820002074 catalytic tetrad [active] 998820002075 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 998820002076 Predicted membrane protein [Function unknown]; Region: COG2323 998820002077 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 998820002078 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 998820002079 substrate binding site [chemical binding]; other site 998820002080 THF binding site; other site 998820002081 zinc-binding site [ion binding]; other site 998820002082 S-ribosylhomocysteinase; Provisional; Region: PRK02260 998820002083 Uncharacterized conserved protein [Function unknown]; Region: COG0398 998820002084 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 998820002085 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 998820002086 RuvA N terminal domain; Region: RuvA_N; pfam01330 998820002087 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 998820002088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 998820002089 Walker A motif; other site 998820002090 ATP binding site [chemical binding]; other site 998820002091 Walker B motif; other site 998820002092 arginine finger; other site 998820002093 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 998820002094 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 998820002095 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 998820002096 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 998820002097 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 998820002098 Preprotein translocase subunit; Region: YajC; pfam02699 998820002099 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 998820002100 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 998820002101 putative catalytic cysteine [active] 998820002102 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 998820002103 putative active site [active] 998820002104 metal binding site [ion binding]; metal-binding site 998820002105 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 998820002106 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 998820002107 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 998820002108 FeoA domain; Region: FeoA; pfam04023 998820002109 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 998820002110 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 998820002111 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 998820002112 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 998820002113 active site 998820002114 DNA polymerase IV; Validated; Region: PRK02406 998820002115 DNA binding site [nucleotide binding] 998820002116 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 998820002117 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 998820002118 DNA-binding site [nucleotide binding]; DNA binding site 998820002119 DRTGG domain; Region: DRTGG; pfam07085 998820002120 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 998820002121 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 998820002122 DHH family; Region: DHH; pfam01368 998820002123 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 998820002124 DEAD-like helicases superfamily; Region: DEXDc; smart00487 998820002125 ATP binding site [chemical binding]; other site 998820002126 Mg++ binding site [ion binding]; other site 998820002127 motif III; other site 998820002128 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 998820002129 nucleotide binding region [chemical binding]; other site 998820002130 ATP-binding site [chemical binding]; other site 998820002131 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 998820002132 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 998820002133 motif 1; other site 998820002134 active site 998820002135 motif 2; other site 998820002136 motif 3; other site 998820002137 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 998820002138 DHHA1 domain; Region: DHHA1; pfam02272 998820002139 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 998820002140 hypothetical protein; Provisional; Region: PRK05473 998820002141 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 998820002142 hypothetical protein; Provisional; Region: PRK13678 998820002143 Cell division protein ZapA; Region: ZapA; pfam05164 998820002144 Colicin V production protein; Region: Colicin_V; pfam02674 998820002145 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 998820002146 MutS domain III; Region: MutS_III; pfam05192 998820002147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820002148 Walker A/P-loop; other site 998820002149 ATP binding site [chemical binding]; other site 998820002150 Q-loop/lid; other site 998820002151 ABC transporter signature motif; other site 998820002152 Walker B; other site 998820002153 D-loop; other site 998820002154 H-loop/switch region; other site 998820002155 V-type ATP synthase subunit H; Validated; Region: PRK06397 998820002156 Smr domain; Region: Smr; pfam01713 998820002157 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 998820002158 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 998820002159 catalytic residues [active] 998820002160 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 998820002161 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 998820002162 acyl-activating enzyme (AAE) consensus motif; other site 998820002163 AMP binding site [chemical binding]; other site 998820002164 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 998820002165 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 998820002166 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 998820002167 DltD N-terminal region; Region: DltD_N; pfam04915 998820002168 DltD central region; Region: DltD_M; pfam04918 998820002169 DltD C-terminal region; Region: DltD_C; pfam04914 998820002170 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 998820002171 glutamate racemase; Provisional; Region: PRK00865 998820002172 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 998820002173 active site 998820002174 dimerization interface [polypeptide binding]; other site 998820002175 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 998820002176 active site 998820002177 metal binding site [ion binding]; metal-binding site 998820002178 homotetramer interface [polypeptide binding]; other site 998820002179 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 998820002180 amphipathic channel; other site 998820002181 Asn-Pro-Ala signature motifs; other site 998820002182 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 998820002183 FOG: CBS domain [General function prediction only]; Region: COG0517 998820002184 Domain of unknown function (DUF368); Region: DUF368; pfam04018 998820002185 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 998820002186 Mechanosensitive ion channel; Region: MS_channel; pfam00924 998820002187 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 998820002188 YtxH-like protein; Region: YtxH; pfam12732 998820002189 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 998820002190 HTH domain; Region: HTH_11; pfam08279 998820002191 3H domain; Region: 3H; pfam02829 998820002192 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 998820002193 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 998820002194 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 998820002195 active site 998820002196 catabolite control protein A; Region: ccpA; TIGR01481 998820002197 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 998820002198 DNA binding site [nucleotide binding] 998820002199 domain linker motif; other site 998820002200 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 998820002201 dimerization interface [polypeptide binding]; other site 998820002202 effector binding site; other site 998820002203 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 998820002204 Helix-turn-helix domain; Region: HTH_38; pfam13936 998820002205 Homeodomain-like domain; Region: HTH_32; pfam13565 998820002206 Integrase core domain; Region: rve; pfam00665 998820002207 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 998820002208 Transglycosylase; Region: Transgly; pfam00912 998820002209 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 998820002210 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 998820002211 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820002212 motif II; other site 998820002213 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 998820002214 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 998820002215 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 998820002216 dipeptidase PepV; Reviewed; Region: PRK07318 998820002217 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 998820002218 active site 998820002219 metal binding site [ion binding]; metal-binding site 998820002220 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 998820002221 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 998820002222 active site 998820002223 catalytic site [active] 998820002224 metal binding site [ion binding]; metal-binding site 998820002225 YibE/F-like protein; Region: YibE_F; pfam07907 998820002226 YibE/F-like protein; Region: YibE_F; pfam07907 998820002227 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 998820002228 putative active site [active] 998820002229 putative metal binding site [ion binding]; other site 998820002230 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 998820002231 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 998820002232 active site 998820002233 metal binding site [ion binding]; metal-binding site 998820002234 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 998820002235 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 998820002236 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 998820002237 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820002238 active site 998820002239 motif I; other site 998820002240 motif II; other site 998820002241 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820002242 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 998820002243 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 998820002244 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 998820002245 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 998820002246 tetramer interfaces [polypeptide binding]; other site 998820002247 binuclear metal-binding site [ion binding]; other site 998820002248 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 998820002249 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 998820002250 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 998820002251 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 998820002252 active site 998820002253 general stress protein 13; Validated; Region: PRK08059 998820002254 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 998820002255 RNA binding site [nucleotide binding]; other site 998820002256 Domain of unknown function (DUF4323); Region: DUF4323; pfam14211 998820002257 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 998820002258 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 998820002259 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 998820002260 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 998820002261 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 998820002262 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 998820002263 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 998820002264 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 998820002265 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 998820002266 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 998820002267 putative ADP-binding pocket [chemical binding]; other site 998820002268 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 998820002269 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 998820002270 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 998820002271 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 998820002272 aromatic amino acid aminotransferase; Validated; Region: PRK07309 998820002273 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 998820002274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 998820002275 homodimer interface [polypeptide binding]; other site 998820002276 catalytic residue [active] 998820002277 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 998820002278 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 998820002279 Sulfatase; Region: Sulfatase; pfam00884 998820002280 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 998820002281 metal binding site 2 [ion binding]; metal-binding site 998820002282 putative DNA binding helix; other site 998820002283 metal binding site 1 [ion binding]; metal-binding site 998820002284 dimer interface [polypeptide binding]; other site 998820002285 structural Zn2+ binding site [ion binding]; other site 998820002286 Domain of unknown function (DUF4323); Region: DUF4323; pfam14211 998820002287 S-adenosylmethionine synthetase; Validated; Region: PRK05250 998820002288 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 998820002289 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 998820002290 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 998820002291 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 998820002292 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820002293 putative substrate translocation pore; other site 998820002294 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 998820002295 DNA binding residues [nucleotide binding] 998820002296 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 998820002297 putative dimer interface [polypeptide binding]; other site 998820002298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820002299 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 998820002300 putative substrate translocation pore; other site 998820002301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820002302 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 998820002303 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 998820002304 active site 998820002305 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 998820002306 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 998820002307 HIGH motif; other site 998820002308 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 998820002309 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 998820002310 active site 998820002311 KMSKS motif; other site 998820002312 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 998820002313 tRNA binding surface [nucleotide binding]; other site 998820002314 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 998820002315 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 998820002316 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 998820002317 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 998820002318 RNA binding surface [nucleotide binding]; other site 998820002319 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 998820002320 active site 998820002321 uracil binding [chemical binding]; other site 998820002322 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 998820002323 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 998820002324 putative substrate binding site [chemical binding]; other site 998820002325 putative ATP binding site [chemical binding]; other site 998820002326 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 998820002327 nudix motif; other site 998820002328 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 998820002329 Int/Topo IB signature motif; other site 998820002330 Abi-like protein; Region: Abi_2; pfam07751 998820002331 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 998820002332 Domain of unknown function (DUF955); Region: DUF955; pfam06114 998820002333 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 998820002334 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 998820002335 non-specific DNA binding site [nucleotide binding]; other site 998820002336 salt bridge; other site 998820002337 sequence-specific DNA binding site [nucleotide binding]; other site 998820002338 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 998820002339 Domain of unknown function (DUF771); Region: DUF771; cl09962 998820002340 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 998820002341 RecT family; Region: RecT; cl04285 998820002342 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 998820002343 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 998820002344 non-specific DNA binding site [nucleotide binding]; other site 998820002345 salt bridge; other site 998820002346 sequence-specific DNA binding site [nucleotide binding]; other site 998820002347 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 998820002348 DNA-binding site [nucleotide binding]; DNA binding site 998820002349 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 998820002350 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 998820002351 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 998820002352 Walker A motif; other site 998820002353 ATP binding site [chemical binding]; other site 998820002354 Walker B motif; other site 998820002355 HNH endonuclease; Region: HNH_3; pfam13392 998820002356 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 998820002357 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 998820002358 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 998820002359 DNA binding residues [nucleotide binding] 998820002360 HNH endonuclease; Region: HNH; pfam01844 998820002361 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 998820002362 Phage-related protein [Function unknown]; Region: COG4695; cl01923 998820002363 Phage portal protein; Region: Phage_portal; pfam04860 998820002364 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 998820002365 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 998820002366 oligomer interface [polypeptide binding]; other site 998820002367 active site residues [active] 998820002368 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 998820002369 Phage capsid family; Region: Phage_capsid; pfam05065 998820002370 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 998820002371 oligomerization interface [polypeptide binding]; other site 998820002372 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 998820002373 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 998820002374 Tropomyosin like; Region: Tropomyosin_1; pfam12718 998820002375 tape measure domain; Region: tape_meas_nterm; TIGR02675 998820002376 Phage-related protein [Function unknown]; Region: COG5412 998820002377 Phage-related protein [Function unknown]; Region: COG4722 998820002378 Phage tail protein; Region: Sipho_tail; cl17486 998820002379 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 998820002380 Protein of unknown function (DUF1617); Region: DUF1617; pfam07761 998820002381 Bacteriophage holin; Region: Phage_holin_1; pfam04531 998820002382 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 998820002383 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 998820002384 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 998820002385 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 998820002386 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 998820002387 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 998820002388 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 998820002389 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 998820002390 catalytic residues [active] 998820002391 dimer interface [polypeptide binding]; other site 998820002392 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 998820002393 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 998820002394 pyridoxal 5'-phosphate binding site [chemical binding]; other site 998820002395 homodimer interface [polypeptide binding]; other site 998820002396 catalytic residue [active] 998820002397 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 998820002398 Helix-turn-helix domain; Region: HTH_38; pfam13936 998820002399 Integrase core domain; Region: rve; pfam00665 998820002400 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 998820002401 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 998820002402 active site 998820002403 metal binding site [ion binding]; metal-binding site 998820002404 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 998820002405 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 998820002406 Competence protein CoiA-like family; Region: CoiA; cl11541 998820002407 Thioredoxin; Region: Thioredoxin_5; pfam13743 998820002408 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 998820002409 putative active site [active] 998820002410 putative metal binding residues [ion binding]; other site 998820002411 signature motif; other site 998820002412 putative triphosphate binding site [ion binding]; other site 998820002413 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 998820002414 synthetase active site [active] 998820002415 NTP binding site [chemical binding]; other site 998820002416 metal binding site [ion binding]; metal-binding site 998820002417 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 998820002418 ATP-NAD kinase; Region: NAD_kinase; pfam01513 998820002419 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 998820002420 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 998820002421 RNA binding surface [nucleotide binding]; other site 998820002422 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 998820002423 active site 998820002424 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 998820002425 ApbE family; Region: ApbE; pfam02424 998820002426 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 998820002427 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 998820002428 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 998820002429 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 998820002430 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 998820002431 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 998820002432 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 998820002433 active site 998820002434 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 998820002435 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 998820002436 Cl binding site [ion binding]; other site 998820002437 oligomer interface [polypeptide binding]; other site 998820002438 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 998820002439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 998820002440 S-adenosylmethionine binding site [chemical binding]; other site 998820002441 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 998820002442 Protein of unknown function (DUF1149); Region: DUF1149; pfam06619 998820002443 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 998820002444 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 998820002445 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 998820002446 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 998820002447 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 998820002448 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 998820002449 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 998820002450 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 998820002451 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 998820002452 classical (c) SDRs; Region: SDR_c; cd05233 998820002453 NAD(P) binding site [chemical binding]; other site 998820002454 active site 998820002455 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 998820002456 Helix-turn-helix domain; Region: HTH_25; pfam13413 998820002457 non-specific DNA binding site [nucleotide binding]; other site 998820002458 salt bridge; other site 998820002459 sequence-specific DNA binding site [nucleotide binding]; other site 998820002460 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 998820002461 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 998820002462 competence damage-inducible protein A; Provisional; Region: PRK00549 998820002463 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 998820002464 putative MPT binding site; other site 998820002465 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 998820002466 recombinase A; Provisional; Region: recA; PRK09354 998820002467 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 998820002468 hexamer interface [polypeptide binding]; other site 998820002469 Walker A motif; other site 998820002470 ATP binding site [chemical binding]; other site 998820002471 Walker B motif; other site 998820002472 ribonuclease Y; Region: RNase_Y; TIGR03319 998820002473 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 998820002474 Zn2+ binding site [ion binding]; other site 998820002475 Mg2+ binding site [ion binding]; other site 998820002476 Uncharacterized conserved protein [Function unknown]; Region: COG1739 998820002477 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 998820002478 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 998820002479 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 998820002480 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 998820002481 ATP binding site [chemical binding]; other site 998820002482 putative Mg++ binding site [ion binding]; other site 998820002483 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 998820002484 nucleotide binding region [chemical binding]; other site 998820002485 ATP-binding site [chemical binding]; other site 998820002486 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 998820002487 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 998820002488 active site 998820002489 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 998820002490 30S subunit binding site; other site 998820002491 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 998820002492 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 998820002493 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 998820002494 nucleotide binding region [chemical binding]; other site 998820002495 ATP-binding site [chemical binding]; other site 998820002496 peptide chain release factor 2; Validated; Region: prfB; PRK00578 998820002497 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 998820002498 PCRF domain; Region: PCRF; pfam03462 998820002499 RF-1 domain; Region: RF-1; pfam00472 998820002500 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 998820002501 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820002502 Walker A/P-loop; other site 998820002503 ATP binding site [chemical binding]; other site 998820002504 Q-loop/lid; other site 998820002505 ABC transporter signature motif; other site 998820002506 Walker B; other site 998820002507 D-loop; other site 998820002508 H-loop/switch region; other site 998820002509 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 998820002510 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 998820002511 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 998820002512 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 998820002513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 998820002514 active site 998820002515 phosphorylation site [posttranslational modification] 998820002516 intermolecular recognition site; other site 998820002517 dimerization interface [polypeptide binding]; other site 998820002518 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 998820002519 DNA binding site [nucleotide binding] 998820002520 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 998820002521 PAS domain; Region: PAS_8; pfam13188 998820002522 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 998820002523 dimer interface [polypeptide binding]; other site 998820002524 phosphorylation site [posttranslational modification] 998820002525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 998820002526 ATP binding site [chemical binding]; other site 998820002527 Mg2+ binding site [ion binding]; other site 998820002528 G-X-G motif; other site 998820002529 phosphate binding protein; Region: ptsS_2; TIGR02136 998820002530 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 998820002531 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 998820002532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820002533 dimer interface [polypeptide binding]; other site 998820002534 conserved gate region; other site 998820002535 putative PBP binding loops; other site 998820002536 ABC-ATPase subunit interface; other site 998820002537 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 998820002538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820002539 dimer interface [polypeptide binding]; other site 998820002540 conserved gate region; other site 998820002541 putative PBP binding loops; other site 998820002542 ABC-ATPase subunit interface; other site 998820002543 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 998820002544 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 998820002545 Walker A/P-loop; other site 998820002546 ATP binding site [chemical binding]; other site 998820002547 Q-loop/lid; other site 998820002548 ABC transporter signature motif; other site 998820002549 Walker B; other site 998820002550 D-loop; other site 998820002551 H-loop/switch region; other site 998820002552 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14255 998820002553 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 998820002554 Walker A/P-loop; other site 998820002555 ATP binding site [chemical binding]; other site 998820002556 Q-loop/lid; other site 998820002557 ABC transporter signature motif; other site 998820002558 Walker B; other site 998820002559 D-loop; other site 998820002560 H-loop/switch region; other site 998820002561 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 998820002562 PhoU domain; Region: PhoU; pfam01895 998820002563 PhoU domain; Region: PhoU; pfam01895 998820002564 Uncharacterized conserved protein [Function unknown]; Region: COG3595 998820002565 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 998820002566 Membrane protein of unknown function; Region: DUF360; pfam04020 998820002567 HPr kinase/phosphorylase; Provisional; Region: PRK05428 998820002568 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 998820002569 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 998820002570 Hpr binding site; other site 998820002571 active site 998820002572 homohexamer subunit interaction site [polypeptide binding]; other site 998820002573 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 998820002574 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 998820002575 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 998820002576 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 998820002577 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 998820002578 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 998820002579 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 998820002580 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 998820002581 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 998820002582 active site 998820002583 substrate binding site [chemical binding]; other site 998820002584 metal binding site [ion binding]; metal-binding site 998820002585 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 998820002586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 998820002587 active site 998820002588 phosphorylation site [posttranslational modification] 998820002589 intermolecular recognition site; other site 998820002590 dimerization interface [polypeptide binding]; other site 998820002591 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 998820002592 DNA binding site [nucleotide binding] 998820002593 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 998820002594 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 998820002595 dimer interface [polypeptide binding]; other site 998820002596 phosphorylation site [posttranslational modification] 998820002597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 998820002598 ATP binding site [chemical binding]; other site 998820002599 Mg2+ binding site [ion binding]; other site 998820002600 G-X-G motif; other site 998820002601 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820002602 Walker A/P-loop; other site 998820002603 ATP binding site [chemical binding]; other site 998820002604 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 998820002605 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 998820002606 Q-loop/lid; other site 998820002607 ABC transporter signature motif; other site 998820002608 Walker B; other site 998820002609 D-loop; other site 998820002610 H-loop/switch region; other site 998820002611 FtsX-like permease family; Region: FtsX; pfam02687 998820002612 HD domain; Region: HD_3; cl17350 998820002613 excinuclease ABC subunit B; Provisional; Region: PRK05298 998820002614 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 998820002615 ATP binding site [chemical binding]; other site 998820002616 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 998820002617 nucleotide binding region [chemical binding]; other site 998820002618 ATP-binding site [chemical binding]; other site 998820002619 Ultra-violet resistance protein B; Region: UvrB; pfam12344 998820002620 UvrB/uvrC motif; Region: UVR; pfam02151 998820002621 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 998820002622 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 998820002623 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 998820002624 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 998820002625 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 998820002626 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 998820002627 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 998820002628 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 998820002629 phosphate binding site [ion binding]; other site 998820002630 putative substrate binding pocket [chemical binding]; other site 998820002631 dimer interface [polypeptide binding]; other site 998820002632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 998820002633 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 998820002634 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 998820002635 MarR family; Region: MarR; pfam01047 998820002636 Clp protease; Region: CLP_protease; pfam00574 998820002637 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 998820002638 oligomer interface [polypeptide binding]; other site 998820002639 active site residues [active] 998820002640 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 998820002641 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 998820002642 Int/Topo IB signature motif; other site 998820002643 Ion transport protein; Region: Ion_trans; pfam00520 998820002644 Ion channel; Region: Ion_trans_2; pfam07885 998820002645 Short C-terminal domain; Region: SHOCT; pfam09851 998820002646 Domain of unknown function (DUF955); Region: DUF955; cl01076 998820002647 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 998820002648 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 998820002649 non-specific DNA binding site [nucleotide binding]; other site 998820002650 salt bridge; other site 998820002651 sequence-specific DNA binding site [nucleotide binding]; other site 998820002652 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 998820002653 sequence-specific DNA binding site [nucleotide binding]; other site 998820002654 salt bridge; other site 998820002655 ORF6N domain; Region: ORF6N; pfam10543 998820002656 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 998820002657 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 998820002658 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 998820002659 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 998820002660 ATP binding site [chemical binding]; other site 998820002661 putative Mg++ binding site [ion binding]; other site 998820002662 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 998820002663 nucleotide binding region [chemical binding]; other site 998820002664 ATP-binding site [chemical binding]; other site 998820002665 AAA domain; Region: AAA_24; pfam13479 998820002666 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 998820002667 polymerase nucleotide-binding site; other site 998820002668 DNA-binding residues [nucleotide binding]; DNA binding site 998820002669 nucleotide binding site [chemical binding]; other site 998820002670 primase nucleotide-binding site [nucleotide binding]; other site 998820002671 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 998820002672 Virulence-associated protein E; Region: VirE; pfam05272 998820002673 VRR-NUC domain; Region: VRR_NUC; pfam08774 998820002674 HNH endonuclease; Region: HNH_3; pfam13392 998820002675 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 998820002676 HNH endonuclease; Region: HNH; pfam01844 998820002677 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 998820002678 Phage-related protein [Function unknown]; Region: COG4695; cl01923 998820002679 Phage portal protein; Region: Phage_portal; pfam04860 998820002680 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 998820002681 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 998820002682 oligomer interface [polypeptide binding]; other site 998820002683 active site residues [active] 998820002684 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 998820002685 Phage capsid family; Region: Phage_capsid; pfam05065 998820002686 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 998820002687 oligomerization interface [polypeptide binding]; other site 998820002688 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 998820002689 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 998820002690 Phage-related minor tail protein [Function unknown]; Region: COG5280 998820002691 Phage-related protein [Function unknown]; Region: COG5412 998820002692 Phage-related protein [Function unknown]; Region: COG4722 998820002693 Phage tail protein; Region: Sipho_tail; cl17486 998820002694 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 998820002695 Protein of unknown function (DUF1617); Region: DUF1617; pfam07761 998820002696 Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890 998820002697 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 998820002698 amidase catalytic site [active] 998820002699 Zn binding residues [ion binding]; other site 998820002700 substrate binding site [chemical binding]; other site 998820002701 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 998820002702 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 998820002703 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 998820002704 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 998820002705 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 998820002706 Phosphoglycerate kinase; Region: PGK; pfam00162 998820002707 substrate binding site [chemical binding]; other site 998820002708 hinge regions; other site 998820002709 ADP binding site [chemical binding]; other site 998820002710 catalytic site [active] 998820002711 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 998820002712 triosephosphate isomerase; Provisional; Region: PRK14567 998820002713 substrate binding site [chemical binding]; other site 998820002714 dimer interface [polypeptide binding]; other site 998820002715 catalytic triad [active] 998820002716 enolase; Provisional; Region: eno; PRK00077 998820002717 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 998820002718 dimer interface [polypeptide binding]; other site 998820002719 metal binding site [ion binding]; metal-binding site 998820002720 substrate binding pocket [chemical binding]; other site 998820002721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820002722 H+ Antiporter protein; Region: 2A0121; TIGR00900 998820002723 putative substrate translocation pore; other site 998820002724 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 998820002725 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 998820002726 Cl- selectivity filter; other site 998820002727 Cl- binding residues [ion binding]; other site 998820002728 pore gating glutamate residue; other site 998820002729 dimer interface [polypeptide binding]; other site 998820002730 H+/Cl- coupling transport residue; other site 998820002731 TrkA-C domain; Region: TrkA_C; pfam02080 998820002732 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 998820002733 Esterase/lipase [General function prediction only]; Region: COG1647 998820002734 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 998820002735 ribonuclease R; Region: RNase_R; TIGR02063 998820002736 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 998820002737 RNB domain; Region: RNB; pfam00773 998820002738 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 998820002739 RNA binding site [nucleotide binding]; other site 998820002740 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 998820002741 SmpB-tmRNA interface; other site 998820002742 Transcriptional regulators [Transcription]; Region: PurR; COG1609 998820002743 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 998820002744 DNA binding site [nucleotide binding] 998820002745 domain linker motif; other site 998820002746 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 998820002747 ligand binding site [chemical binding]; other site 998820002748 dimerization interface [polypeptide binding]; other site 998820002749 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 998820002750 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 998820002751 Ca binding site [ion binding]; other site 998820002752 active site 998820002753 catalytic site [active] 998820002754 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 998820002755 homodimer interface [polypeptide binding]; other site 998820002756 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 998820002757 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 998820002758 active site 998820002759 homodimer interface [polypeptide binding]; other site 998820002760 catalytic site [active] 998820002761 maltose phosphorylase; Provisional; Region: PRK13807 998820002762 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 998820002763 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 998820002764 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 998820002765 beta-phosphoglucomutase; Region: bPGM; TIGR01990 998820002766 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820002767 motif II; other site 998820002768 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 998820002769 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 998820002770 Walker A/P-loop; other site 998820002771 ATP binding site [chemical binding]; other site 998820002772 Q-loop/lid; other site 998820002773 ABC transporter signature motif; other site 998820002774 Walker B; other site 998820002775 D-loop; other site 998820002776 H-loop/switch region; other site 998820002777 TOBE domain; Region: TOBE_2; pfam08402 998820002778 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 998820002779 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 998820002780 Ca binding site [ion binding]; other site 998820002781 active site 998820002782 catalytic site [active] 998820002783 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 998820002784 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 998820002785 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 998820002786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820002787 dimer interface [polypeptide binding]; other site 998820002788 conserved gate region; other site 998820002789 putative PBP binding loops; other site 998820002790 ABC-ATPase subunit interface; other site 998820002791 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 998820002792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820002793 dimer interface [polypeptide binding]; other site 998820002794 conserved gate region; other site 998820002795 ABC-ATPase subunit interface; other site 998820002796 ATP synthase regulation protein NCA2; Region: NCA2; pfam08637 998820002797 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 998820002798 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 998820002799 non-specific DNA binding site [nucleotide binding]; other site 998820002800 salt bridge; other site 998820002801 sequence-specific DNA binding site [nucleotide binding]; other site 998820002802 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 998820002803 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 998820002804 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 998820002805 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 998820002806 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 998820002807 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 998820002808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820002809 dimer interface [polypeptide binding]; other site 998820002810 conserved gate region; other site 998820002811 putative PBP binding loops; other site 998820002812 ABC-ATPase subunit interface; other site 998820002813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820002814 dimer interface [polypeptide binding]; other site 998820002815 conserved gate region; other site 998820002816 putative PBP binding loops; other site 998820002817 ABC-ATPase subunit interface; other site 998820002818 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 998820002819 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820002820 Walker A/P-loop; other site 998820002821 ATP binding site [chemical binding]; other site 998820002822 Q-loop/lid; other site 998820002823 ABC transporter signature motif; other site 998820002824 Walker B; other site 998820002825 D-loop; other site 998820002826 H-loop/switch region; other site 998820002827 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 998820002828 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 998820002829 Coenzyme A binding pocket [chemical binding]; other site 998820002830 Tubby C 2; Region: Tub_2; cl02043 998820002831 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820002832 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 998820002833 active site 998820002834 motif I; other site 998820002835 motif II; other site 998820002836 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 998820002837 ligand binding site [chemical binding]; other site 998820002838 active site 998820002839 UGI interface [polypeptide binding]; other site 998820002840 catalytic site [active] 998820002841 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 998820002842 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 998820002843 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 998820002844 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820002845 Walker A/P-loop; other site 998820002846 ATP binding site [chemical binding]; other site 998820002847 Q-loop/lid; other site 998820002848 ABC transporter signature motif; other site 998820002849 Walker B; other site 998820002850 D-loop; other site 998820002851 H-loop/switch region; other site 998820002852 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 998820002853 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 998820002854 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 998820002855 active site 998820002856 catalytic site [active] 998820002857 substrate binding site [chemical binding]; other site 998820002858 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 998820002859 active site 998820002860 putative catalytic site [active] 998820002861 DNA binding site [nucleotide binding] 998820002862 putative phosphate binding site [ion binding]; other site 998820002863 metal binding site A [ion binding]; metal-binding site 998820002864 AP binding site [nucleotide binding]; other site 998820002865 metal binding site B [ion binding]; metal-binding site 998820002866 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 998820002867 FAD binding domain; Region: FAD_binding_4; pfam01565 998820002868 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 998820002869 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 998820002870 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 998820002871 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 998820002872 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 998820002873 non-specific DNA binding site [nucleotide binding]; other site 998820002874 salt bridge; other site 998820002875 sequence-specific DNA binding site [nucleotide binding]; other site 998820002876 Cupin domain; Region: Cupin_2; pfam07883 998820002877 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 998820002878 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 998820002879 Walker A/P-loop; other site 998820002880 ATP binding site [chemical binding]; other site 998820002881 Q-loop/lid; other site 998820002882 ABC transporter signature motif; other site 998820002883 Walker B; other site 998820002884 D-loop; other site 998820002885 H-loop/switch region; other site 998820002886 TOBE domain; Region: TOBE_2; pfam08402 998820002887 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 998820002888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820002889 dimer interface [polypeptide binding]; other site 998820002890 conserved gate region; other site 998820002891 putative PBP binding loops; other site 998820002892 ABC-ATPase subunit interface; other site 998820002893 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 998820002894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820002895 dimer interface [polypeptide binding]; other site 998820002896 conserved gate region; other site 998820002897 putative PBP binding loops; other site 998820002898 ABC-ATPase subunit interface; other site 998820002899 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 998820002900 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 998820002901 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 998820002902 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 998820002903 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 998820002904 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 998820002905 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820002906 motif II; other site 998820002907 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 998820002908 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 998820002909 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 998820002910 PXA domain; Region: PXA; cl02564 998820002911 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 998820002912 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 998820002913 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 998820002914 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 998820002915 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 998820002916 Walker A/P-loop; other site 998820002917 ATP binding site [chemical binding]; other site 998820002918 Q-loop/lid; other site 998820002919 ABC transporter signature motif; other site 998820002920 Walker B; other site 998820002921 D-loop; other site 998820002922 H-loop/switch region; other site 998820002923 Uncharacterized conserved protein [Function unknown]; Region: COG1624 998820002924 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 998820002925 YbbR-like protein; Region: YbbR; pfam07949 998820002926 YbbR-like protein; Region: YbbR; pfam07949 998820002927 YbbR-like protein; Region: YbbR; pfam07949 998820002928 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 998820002929 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 998820002930 active site 998820002931 substrate binding site [chemical binding]; other site 998820002932 metal binding site [ion binding]; metal-binding site 998820002933 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 998820002934 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 998820002935 glutaminase active site [active] 998820002936 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 998820002937 dimer interface [polypeptide binding]; other site 998820002938 active site 998820002939 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 998820002940 dimer interface [polypeptide binding]; other site 998820002941 active site 998820002942 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 998820002943 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 998820002944 active site 998820002945 Zn binding site [ion binding]; other site 998820002946 hypothetical protein; Validated; Region: PRK00110 998820002947 Type II/IV secretion system protein; Region: T2SE; pfam00437 998820002948 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 998820002949 Walker A motif; other site 998820002950 ATP binding site [chemical binding]; other site 998820002951 Walker B motif; other site 998820002952 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 998820002953 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 998820002954 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 998820002955 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 998820002956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 998820002957 S-adenosylmethionine binding site [chemical binding]; other site 998820002958 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 998820002959 Spore germination protein; Region: Spore_permease; cl17796 998820002960 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 998820002961 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 998820002962 putative acyl-acceptor binding pocket; other site 998820002963 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 998820002964 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 998820002965 Ligand binding site; other site 998820002966 metal-binding site 998820002967 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 998820002968 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 998820002969 Ligand binding site; other site 998820002970 metal-binding site 998820002971 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 998820002972 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 998820002973 putative acyl-acceptor binding pocket; other site 998820002974 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 998820002975 SdpI/YhfL protein family; Region: SdpI; pfam13630 998820002976 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 998820002977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 998820002978 active site 998820002979 phosphorylation site [posttranslational modification] 998820002980 intermolecular recognition site; other site 998820002981 dimerization interface [polypeptide binding]; other site 998820002982 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 998820002983 DNA binding site [nucleotide binding] 998820002984 hypothetical protein; Provisional; Region: PRK04435 998820002985 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 998820002986 DNA-binding interface [nucleotide binding]; DNA binding site 998820002987 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 998820002988 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 998820002989 active site 998820002990 catalytic triad [active] 998820002991 oxyanion hole [active] 998820002992 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 998820002993 Part of AAA domain; Region: AAA_19; pfam13245 998820002994 Family description; Region: UvrD_C_2; pfam13538 998820002995 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 998820002996 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 998820002997 nucleotide binding pocket [chemical binding]; other site 998820002998 K-X-D-G motif; other site 998820002999 catalytic site [active] 998820003000 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 998820003001 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 998820003002 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 998820003003 Dimer interface [polypeptide binding]; other site 998820003004 BRCT sequence motif; other site 998820003005 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 998820003006 putative dimer interface [polypeptide binding]; other site 998820003007 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 998820003008 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 998820003009 putative dimer interface [polypeptide binding]; other site 998820003010 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 998820003011 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 998820003012 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 998820003013 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 998820003014 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 998820003015 GatB domain; Region: GatB_Yqey; smart00845 998820003016 putative lipid kinase; Reviewed; Region: PRK13055 998820003017 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 998820003018 TRAM domain; Region: TRAM; pfam01938 998820003019 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 998820003020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 998820003021 S-adenosylmethionine binding site [chemical binding]; other site 998820003022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820003023 Major Facilitator Superfamily; Region: MFS_1; pfam07690 998820003024 putative substrate translocation pore; other site 998820003025 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820003026 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 998820003027 active site 998820003028 motif I; other site 998820003029 motif II; other site 998820003030 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 998820003031 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 998820003032 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 998820003033 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 998820003034 active site 998820003035 Zn binding site [ion binding]; other site 998820003036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820003037 Major Facilitator Superfamily; Region: MFS_1; pfam07690 998820003038 putative substrate translocation pore; other site 998820003039 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 998820003040 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 998820003041 Coenzyme A binding pocket [chemical binding]; other site 998820003042 EDD domain protein, DegV family; Region: DegV; TIGR00762 998820003043 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 998820003044 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 998820003045 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 998820003046 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419 998820003047 active site 998820003048 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 998820003049 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 998820003050 formate dehydrogenase; Provisional; Region: PRK07574 998820003051 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 998820003052 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 998820003053 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 998820003054 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 998820003055 ATP binding site [chemical binding]; other site 998820003056 putative Mg++ binding site [ion binding]; other site 998820003057 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 998820003058 nucleotide binding region [chemical binding]; other site 998820003059 ATP-binding site [chemical binding]; other site 998820003060 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 998820003061 active site 998820003062 methionine cluster; other site 998820003063 phosphorylation site [posttranslational modification] 998820003064 metal binding site [ion binding]; metal-binding site 998820003065 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 998820003066 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 998820003067 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 998820003068 ATP binding site [chemical binding]; other site 998820003069 putative Mg++ binding site [ion binding]; other site 998820003070 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 998820003071 nucleotide binding region [chemical binding]; other site 998820003072 ATP-binding site [chemical binding]; other site 998820003073 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 998820003074 HRDC domain; Region: HRDC; pfam00570 998820003075 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 998820003076 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 998820003077 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 998820003078 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 998820003079 WHG domain; Region: WHG; pfam13305 998820003080 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 998820003081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 998820003082 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 998820003083 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 998820003084 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 998820003085 active site 998820003086 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 998820003087 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 998820003088 active site 998820003089 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 998820003090 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 998820003091 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 998820003092 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 998820003093 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 998820003094 active site 998820003095 tetramer interface; other site 998820003096 putative transposase OrfB; Reviewed; Region: PHA02517 998820003097 HTH-like domain; Region: HTH_21; pfam13276 998820003098 Integrase core domain; Region: rve; pfam00665 998820003099 Integrase core domain; Region: rve_3; pfam13683 998820003100 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 998820003101 Homeodomain-like domain; Region: HTH_23; cl17451 998820003102 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 998820003103 Transposase; Region: HTH_Tnp_1; cl17663 998820003104 Helix-turn-helix domain; Region: HTH_28; pfam13518 998820003105 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 998820003106 active site 998820003107 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 998820003108 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 998820003109 NAD(P) binding site [chemical binding]; other site 998820003110 active site 998820003111 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 998820003112 Helix-turn-helix domain; Region: HTH_38; pfam13936 998820003113 Integrase core domain; Region: rve; pfam00665 998820003114 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 998820003115 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 998820003116 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 998820003117 beta-galactosidase; Region: BGL; TIGR03356 998820003118 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 998820003119 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 998820003120 active site turn [active] 998820003121 phosphorylation site [posttranslational modification] 998820003122 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 998820003123 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 998820003124 HPr interaction site; other site 998820003125 glycerol kinase (GK) interaction site [polypeptide binding]; other site 998820003126 active site 998820003127 phosphorylation site [posttranslational modification] 998820003128 transcriptional antiterminator BglG; Provisional; Region: PRK09772 998820003129 CAT RNA binding domain; Region: CAT_RBD; smart01061 998820003130 PRD domain; Region: PRD; pfam00874 998820003131 PRD domain; Region: PRD; pfam00874 998820003132 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 998820003133 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 998820003134 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 998820003135 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 998820003136 Ligand binding site; other site 998820003137 Putative Catalytic site; other site 998820003138 DXD motif; other site 998820003139 Predicted membrane protein [Function unknown]; Region: COG4129 998820003140 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 998820003141 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 998820003142 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 998820003143 DNA-binding site [nucleotide binding]; DNA binding site 998820003144 RNA-binding motif; other site 998820003145 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 998820003146 Coenzyme A binding pocket [chemical binding]; other site 998820003147 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 998820003148 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 998820003149 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 998820003150 active site 998820003151 xanthine permease; Region: pbuX; TIGR03173 998820003152 ATP-grasp domain; Region: ATP-grasp_4; cl17255 998820003153 adenylosuccinate lyase; Provisional; Region: PRK07492 998820003154 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 998820003155 tetramer interface [polypeptide binding]; other site 998820003156 active site 998820003157 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 998820003158 Sulfatase; Region: Sulfatase; pfam00884 998820003159 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 998820003160 Sugar transport protein; Region: Sugar_transport; pfam06800 998820003161 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 998820003162 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 998820003163 active site 998820003164 dimer interface [polypeptide binding]; other site 998820003165 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 998820003166 dimer interface [polypeptide binding]; other site 998820003167 active site 998820003168 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 998820003169 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 998820003170 Int/Topo IB signature motif; other site 998820003171 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 998820003172 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 998820003173 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 998820003174 Domain of unknown function (DUF955); Region: DUF955; cl01076 998820003175 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 998820003176 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 998820003177 non-specific DNA binding site [nucleotide binding]; other site 998820003178 salt bridge; other site 998820003179 sequence-specific DNA binding site [nucleotide binding]; other site 998820003180 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 998820003181 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 998820003182 non-specific DNA binding site [nucleotide binding]; other site 998820003183 salt bridge; other site 998820003184 sequence-specific DNA binding site [nucleotide binding]; other site 998820003185 Thylakoid formation protein; Region: ThylakoidFormat; cl12138 998820003186 RecT family; Region: RecT; cl04285 998820003187 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 998820003188 Helix-turn-helix domain; Region: HTH_36; pfam13730 998820003189 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 998820003190 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 998820003191 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 998820003192 non-specific DNA binding site [nucleotide binding]; other site 998820003193 salt bridge; other site 998820003194 sequence-specific DNA binding site [nucleotide binding]; other site 998820003195 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 998820003196 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 998820003197 GcrA cell cycle regulator; Region: GcrA; cl11564 998820003198 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 998820003199 Terminase small subunit; Region: Terminase_2; pfam03592 998820003200 Phage terminase large subunit; Region: Terminase_3; cl12054 998820003201 Terminase-like family; Region: Terminase_6; pfam03237 998820003202 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 998820003203 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 998820003204 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 998820003205 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 998820003206 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 998820003207 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 998820003208 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 998820003209 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 998820003210 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 998820003211 Phage protein; Region: DUF3647; pfam12363 998820003212 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 998820003213 Phage-related protein [Function unknown]; Region: COG5412 998820003214 Phage tail protein; Region: Sipho_tail; pfam05709 998820003215 Phage tail protein; Region: Sipho_tail; cl17486 998820003216 Phage tail protein; Region: Sipho_tail; cl17486 998820003217 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 998820003218 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 998820003219 Bacteriophage holin; Region: Phage_holin_1; pfam04531 998820003220 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 998820003221 active site 998820003222 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 998820003223 Bacterial SH3 domain; Region: SH3_5; pfam08460 998820003224 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 998820003225 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 998820003226 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 998820003227 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 998820003228 Uncharacterized conserved protein [Function unknown]; Region: COG1359 998820003229 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 998820003230 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 998820003231 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 998820003232 Helix-turn-helix domain; Region: HTH_38; pfam13936 998820003233 Integrase core domain; Region: rve; pfam00665 998820003234 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 998820003235 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 998820003236 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 998820003237 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 998820003238 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 998820003239 nucleoside/Zn binding site; other site 998820003240 dimer interface [polypeptide binding]; other site 998820003241 catalytic motif [active] 998820003242 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 998820003243 TspO/MBR family; Region: TspO_MBR; pfam03073 998820003244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820003245 Major Facilitator Superfamily; Region: MFS_1; pfam07690 998820003246 putative substrate translocation pore; other site 998820003247 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 998820003248 Peptidase family C69; Region: Peptidase_C69; pfam03577 998820003249 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 998820003250 catalytic core [active] 998820003251 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 998820003252 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 998820003253 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 998820003254 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 998820003255 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 998820003256 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820003257 Walker A/P-loop; other site 998820003258 ATP binding site [chemical binding]; other site 998820003259 Q-loop/lid; other site 998820003260 ABC transporter signature motif; other site 998820003261 Walker B; other site 998820003262 D-loop; other site 998820003263 H-loop/switch region; other site 998820003264 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 998820003265 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 998820003266 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 998820003267 Walker A/P-loop; other site 998820003268 ATP binding site [chemical binding]; other site 998820003269 Q-loop/lid; other site 998820003270 ABC transporter signature motif; other site 998820003271 Walker B; other site 998820003272 D-loop; other site 998820003273 H-loop/switch region; other site 998820003274 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 998820003275 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 998820003276 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 998820003277 putative metal binding site [ion binding]; other site 998820003278 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 998820003279 active site 998820003280 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 998820003281 Beta-lactamase; Region: Beta-lactamase; pfam00144 998820003282 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 998820003283 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 998820003284 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 998820003285 thymidine kinase; Provisional; Region: PRK04296 998820003286 peptide chain release factor 1; Validated; Region: prfA; PRK00591 998820003287 This domain is found in peptide chain release factors; Region: PCRF; smart00937 998820003288 RF-1 domain; Region: RF-1; pfam00472 998820003289 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 998820003290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 998820003291 S-adenosylmethionine binding site [chemical binding]; other site 998820003292 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 998820003293 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 998820003294 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 998820003295 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 998820003296 dimer interface [polypeptide binding]; other site 998820003297 active site 998820003298 glycine-pyridoxal phosphate binding site [chemical binding]; other site 998820003299 folate binding site [chemical binding]; other site 998820003300 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 998820003301 active site 998820003302 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 998820003303 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 998820003304 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 998820003305 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 998820003306 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 998820003307 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 998820003308 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 998820003309 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 998820003310 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 998820003311 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 998820003312 beta subunit interaction interface [polypeptide binding]; other site 998820003313 Walker A motif; other site 998820003314 ATP binding site [chemical binding]; other site 998820003315 Walker B motif; other site 998820003316 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 998820003317 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 998820003318 core domain interface [polypeptide binding]; other site 998820003319 delta subunit interface [polypeptide binding]; other site 998820003320 epsilon subunit interface [polypeptide binding]; other site 998820003321 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 998820003322 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 998820003323 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 998820003324 alpha subunit interaction interface [polypeptide binding]; other site 998820003325 Walker A motif; other site 998820003326 ATP binding site [chemical binding]; other site 998820003327 Walker B motif; other site 998820003328 inhibitor binding site; inhibition site 998820003329 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 998820003330 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 998820003331 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 998820003332 gamma subunit interface [polypeptide binding]; other site 998820003333 epsilon subunit interface [polypeptide binding]; other site 998820003334 LBP interface [polypeptide binding]; other site 998820003335 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 998820003336 rod shape-determining protein MreB; Provisional; Region: PRK13930 998820003337 MreB and similar proteins; Region: MreB_like; cd10225 998820003338 nucleotide binding site [chemical binding]; other site 998820003339 Mg binding site [ion binding]; other site 998820003340 putative protofilament interaction site [polypeptide binding]; other site 998820003341 RodZ interaction site [polypeptide binding]; other site 998820003342 Haemolytic domain; Region: Haemolytic; cl00506 998820003343 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 998820003344 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 998820003345 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 998820003346 lipoyl attachment site [posttranslational modification]; other site 998820003347 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 998820003348 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 998820003349 metal binding site [ion binding]; metal-binding site 998820003350 dimer interface [polypeptide binding]; other site 998820003351 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 998820003352 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 998820003353 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 998820003354 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 998820003355 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 998820003356 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 998820003357 Walker A/P-loop; other site 998820003358 ATP binding site [chemical binding]; other site 998820003359 Q-loop/lid; other site 998820003360 ABC transporter signature motif; other site 998820003361 Walker B; other site 998820003362 D-loop; other site 998820003363 H-loop/switch region; other site 998820003364 NIL domain; Region: NIL; pfam09383 998820003365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820003366 dimer interface [polypeptide binding]; other site 998820003367 conserved gate region; other site 998820003368 ABC-ATPase subunit interface; other site 998820003369 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 998820003370 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 998820003371 Walker A/P-loop; other site 998820003372 ATP binding site [chemical binding]; other site 998820003373 Q-loop/lid; other site 998820003374 ABC transporter signature motif; other site 998820003375 Walker B; other site 998820003376 D-loop; other site 998820003377 H-loop/switch region; other site 998820003378 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 998820003379 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 998820003380 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 998820003381 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 998820003382 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 998820003383 catalytic residue [active] 998820003384 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 998820003385 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 998820003386 trimerization site [polypeptide binding]; other site 998820003387 active site 998820003388 FeS assembly protein SufB; Region: sufB; TIGR01980 998820003389 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 998820003390 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 998820003391 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 998820003392 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 998820003393 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820003394 active site 998820003395 motif I; other site 998820003396 motif II; other site 998820003397 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 998820003398 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 998820003399 non-specific DNA binding site [nucleotide binding]; other site 998820003400 salt bridge; other site 998820003401 sequence-specific DNA binding site [nucleotide binding]; other site 998820003402 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 998820003403 Ligand Binding Site [chemical binding]; other site 998820003404 recombination factor protein RarA; Reviewed; Region: PRK13342 998820003405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 998820003406 Walker A motif; other site 998820003407 ATP binding site [chemical binding]; other site 998820003408 Walker B motif; other site 998820003409 arginine finger; other site 998820003410 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 998820003411 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 998820003412 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 998820003413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 998820003414 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 998820003415 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 998820003416 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 998820003417 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 998820003418 putative L-serine binding site [chemical binding]; other site 998820003419 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 998820003420 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 998820003421 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 998820003422 catalytic core [active] 998820003423 methionine sulfoxide reductase A; Provisional; Region: PRK14054 998820003424 short chain dehydrogenase; Provisional; Region: PRK06197 998820003425 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 998820003426 putative NAD(P) binding site [chemical binding]; other site 998820003427 active site 998820003428 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 998820003429 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 998820003430 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 998820003431 active site 998820003432 hypothetical protein; Provisional; Region: PRK07329 998820003433 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 998820003434 active site 998820003435 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 998820003436 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 998820003437 peptide binding site [polypeptide binding]; other site 998820003438 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 998820003439 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 998820003440 dimer interface [polypeptide binding]; other site 998820003441 phosphorylation site [posttranslational modification] 998820003442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 998820003443 ATP binding site [chemical binding]; other site 998820003444 Mg2+ binding site [ion binding]; other site 998820003445 G-X-G motif; other site 998820003446 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 998820003447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 998820003448 active site 998820003449 phosphorylation site [posttranslational modification] 998820003450 intermolecular recognition site; other site 998820003451 dimerization interface [polypeptide binding]; other site 998820003452 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 998820003453 DNA binding site [nucleotide binding] 998820003454 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 998820003455 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820003456 Walker A/P-loop; other site 998820003457 ATP binding site [chemical binding]; other site 998820003458 Q-loop/lid; other site 998820003459 ABC transporter signature motif; other site 998820003460 Walker B; other site 998820003461 D-loop; other site 998820003462 H-loop/switch region; other site 998820003463 Transcriptional regulator [Transcription]; Region: LysR; COG0583 998820003464 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 998820003465 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 998820003466 dimerization interface [polypeptide binding]; other site 998820003467 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 998820003468 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 998820003469 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 998820003470 NADH(P)-binding; Region: NAD_binding_10; pfam13460 998820003471 NAD(P) binding site [chemical binding]; other site 998820003472 active site 998820003473 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 998820003474 dimerization interface [polypeptide binding]; other site 998820003475 putative DNA binding site [nucleotide binding]; other site 998820003476 putative Zn2+ binding site [ion binding]; other site 998820003477 glutathionine S-transferase; Provisional; Region: PRK10542 998820003478 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 998820003479 C-terminal domain interface [polypeptide binding]; other site 998820003480 GSH binding site (G-site) [chemical binding]; other site 998820003481 dimer interface [polypeptide binding]; other site 998820003482 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 998820003483 dimer interface [polypeptide binding]; other site 998820003484 substrate binding pocket (H-site) [chemical binding]; other site 998820003485 N-terminal domain interface [polypeptide binding]; other site 998820003486 SAP domain; Region: SAP; pfam02037 998820003487 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 998820003488 Coenzyme A binding pocket [chemical binding]; other site 998820003489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 998820003490 Coenzyme A binding pocket [chemical binding]; other site 998820003491 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 998820003492 Coenzyme A binding pocket [chemical binding]; other site 998820003493 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 998820003494 EDD domain protein, DegV family; Region: DegV; TIGR00762 998820003495 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 998820003496 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 998820003497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 998820003498 active site 998820003499 phosphorylation site [posttranslational modification] 998820003500 intermolecular recognition site; other site 998820003501 dimerization interface [polypeptide binding]; other site 998820003502 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 998820003503 DNA binding residues [nucleotide binding] 998820003504 dimerization interface [polypeptide binding]; other site 998820003505 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 998820003506 Histidine kinase; Region: HisKA_3; pfam07730 998820003507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 998820003508 ATP binding site [chemical binding]; other site 998820003509 Mg2+ binding site [ion binding]; other site 998820003510 G-X-G motif; other site 998820003511 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 998820003512 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 998820003513 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 998820003514 Walker A/P-loop; other site 998820003515 ATP binding site [chemical binding]; other site 998820003516 Q-loop/lid; other site 998820003517 ABC transporter signature motif; other site 998820003518 Walker B; other site 998820003519 D-loop; other site 998820003520 H-loop/switch region; other site 998820003521 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 998820003522 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 998820003523 DNA binding residues [nucleotide binding] 998820003524 dimer interface [polypeptide binding]; other site 998820003525 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 998820003526 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 998820003527 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 998820003528 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 998820003529 Coenzyme A binding pocket [chemical binding]; other site 998820003530 RelB antitoxin; Region: RelB; cl01171 998820003531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 998820003532 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 998820003533 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 998820003534 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 998820003535 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 998820003536 RNA binding site [nucleotide binding]; other site 998820003537 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 998820003538 Helix-turn-helix domain; Region: HTH_38; pfam13936 998820003539 Integrase core domain; Region: rve; pfam00665 998820003540 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 998820003541 Transposase domain (DUF772); Region: DUF772; pfam05598 998820003542 AAA-like domain; Region: AAA_10; pfam12846 998820003543 Domain of unknown function DUF87; Region: DUF87; pfam01935 998820003544 SIR2-like domain; Region: SIR2_2; pfam13289 998820003545 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 998820003546 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 998820003547 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 998820003548 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 998820003549 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 998820003550 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 998820003551 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 998820003552 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 998820003553 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 998820003554 RNA binding surface [nucleotide binding]; other site 998820003555 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 998820003556 GAF domain; Region: GAF_2; pfam13185 998820003557 septation ring formation regulator EzrA; Provisional; Region: PRK04778 998820003558 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 998820003559 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 998820003560 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 998820003561 catalytic residue [active] 998820003562 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 998820003563 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 998820003564 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 998820003565 Ligand Binding Site [chemical binding]; other site 998820003566 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 998820003567 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 998820003568 CoA binding domain; Region: CoA_binding; pfam02629 998820003569 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 998820003570 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 998820003571 active site 998820003572 HIGH motif; other site 998820003573 nucleotide binding site [chemical binding]; other site 998820003574 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 998820003575 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 998820003576 active site 998820003577 KMSKS motif; other site 998820003578 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 998820003579 tRNA binding surface [nucleotide binding]; other site 998820003580 anticodon binding site; other site 998820003581 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 998820003582 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 998820003583 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 998820003584 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 998820003585 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820003586 motif II; other site 998820003587 hypothetical protein; Reviewed; Region: PRK00024 998820003588 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 998820003589 MPN+ (JAMM) motif; other site 998820003590 Zinc-binding site [ion binding]; other site 998820003591 rod shape-determining protein MreB; Provisional; Region: PRK13927 998820003592 MreB and similar proteins; Region: MreB_like; cd10225 998820003593 nucleotide binding site [chemical binding]; other site 998820003594 Mg binding site [ion binding]; other site 998820003595 putative protofilament interaction site [polypeptide binding]; other site 998820003596 RodZ interaction site [polypeptide binding]; other site 998820003597 rod shape-determining protein MreC; Provisional; Region: PRK13922 998820003598 rod shape-determining protein MreC; Region: MreC; pfam04085 998820003599 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 998820003600 septum formation inhibitor; Reviewed; Region: minC; PRK00513 998820003601 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 998820003602 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 998820003603 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 998820003604 Switch I; other site 998820003605 Switch II; other site 998820003606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820003607 dimer interface [polypeptide binding]; other site 998820003608 conserved gate region; other site 998820003609 putative PBP binding loops; other site 998820003610 ABC-ATPase subunit interface; other site 998820003611 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 998820003612 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820003613 Walker A/P-loop; other site 998820003614 ATP binding site [chemical binding]; other site 998820003615 Q-loop/lid; other site 998820003616 ABC transporter signature motif; other site 998820003617 Walker B; other site 998820003618 D-loop; other site 998820003619 H-loop/switch region; other site 998820003620 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 998820003621 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 998820003622 substrate binding pocket [chemical binding]; other site 998820003623 membrane-bound complex binding site; other site 998820003624 hinge residues; other site 998820003625 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 998820003626 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 998820003627 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 998820003628 putative active site [active] 998820003629 catalytic site [active] 998820003630 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 998820003631 putative active site [active] 998820003632 catalytic site [active] 998820003633 cell division protein MraZ; Reviewed; Region: PRK00326 998820003634 MraZ protein; Region: MraZ; pfam02381 998820003635 MraZ protein; Region: MraZ; pfam02381 998820003636 MraW methylase family; Region: Methyltransf_5; pfam01795 998820003637 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 998820003638 Cell division protein FtsL; Region: FtsL; cl11433 998820003639 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 998820003640 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 998820003641 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 998820003642 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 998820003643 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 998820003644 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 998820003645 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 998820003646 Mg++ binding site [ion binding]; other site 998820003647 putative catalytic motif [active] 998820003648 putative substrate binding site [chemical binding]; other site 998820003649 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 998820003650 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 998820003651 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 998820003652 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 998820003653 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 998820003654 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 998820003655 active site 998820003656 homodimer interface [polypeptide binding]; other site 998820003657 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 998820003658 Cell division protein FtsQ; Region: FtsQ; pfam03799 998820003659 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 998820003660 Cell division protein FtsA; Region: FtsA; smart00842 998820003661 Cell division protein FtsA; Region: FtsA; pfam14450 998820003662 cell division protein FtsZ; Validated; Region: PRK09330 998820003663 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 998820003664 nucleotide binding site [chemical binding]; other site 998820003665 SulA interaction site; other site 998820003666 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 998820003667 YGGT family; Region: YGGT; pfam02325 998820003668 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 998820003669 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 998820003670 RNA binding surface [nucleotide binding]; other site 998820003671 DivIVA protein; Region: DivIVA; pfam05103 998820003672 DivIVA domain; Region: DivI1A_domain; TIGR03544 998820003673 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 998820003674 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 998820003675 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 998820003676 active site 998820003677 HIGH motif; other site 998820003678 nucleotide binding site [chemical binding]; other site 998820003679 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 998820003680 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 998820003681 active site 998820003682 KMSKS motif; other site 998820003683 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 998820003684 tRNA binding surface [nucleotide binding]; other site 998820003685 anticodon binding site; other site 998820003686 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 998820003687 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 998820003688 DNA-binding site [nucleotide binding]; DNA binding site 998820003689 RNA-binding motif; other site 998820003690 PBP superfamily domain; Region: PBP_like_2; cl17296 998820003691 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 998820003692 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 998820003693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820003694 putative substrate translocation pore; other site 998820003695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820003696 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 998820003697 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 998820003698 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 998820003699 dimer interface [polypeptide binding]; other site 998820003700 ADP-ribose binding site [chemical binding]; other site 998820003701 active site 998820003702 nudix motif; other site 998820003703 metal binding site [ion binding]; metal-binding site 998820003704 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 998820003705 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 998820003706 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 998820003707 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 998820003708 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 998820003709 catalytic residue [active] 998820003710 Putative amino acid metabolism; Region: DUF1831; pfam08866 998820003711 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820003712 Walker A/P-loop; other site 998820003713 ATP binding site [chemical binding]; other site 998820003714 Q-loop/lid; other site 998820003715 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820003716 ABC transporter signature motif; other site 998820003717 Walker B; other site 998820003718 D-loop; other site 998820003719 H-loop/switch region; other site 998820003720 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820003721 AAA domain; Region: AAA_21; pfam13304 998820003722 Walker A/P-loop; other site 998820003723 ATP binding site [chemical binding]; other site 998820003724 Q-loop/lid; other site 998820003725 ABC transporter signature motif; other site 998820003726 Walker B; other site 998820003727 D-loop; other site 998820003728 H-loop/switch region; other site 998820003729 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 998820003730 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 998820003731 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 998820003732 catalytic core [active] 998820003733 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 998820003734 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 998820003735 AAA domain; Region: AAA_30; pfam13604 998820003736 Family description; Region: UvrD_C_2; pfam13538 998820003737 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 998820003738 Sterol carrier protein domain; Region: SCP2_2; pfam13530 998820003739 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 998820003740 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 998820003741 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 998820003742 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 998820003743 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 998820003744 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 998820003745 active site 998820003746 catalytic residues [active] 998820003747 metal binding site [ion binding]; metal-binding site 998820003748 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 998820003749 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 998820003750 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 998820003751 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 998820003752 TPP-binding site [chemical binding]; other site 998820003753 tetramer interface [polypeptide binding]; other site 998820003754 heterodimer interface [polypeptide binding]; other site 998820003755 phosphorylation loop region [posttranslational modification] 998820003756 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 998820003757 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 998820003758 alpha subunit interface [polypeptide binding]; other site 998820003759 TPP binding site [chemical binding]; other site 998820003760 heterodimer interface [polypeptide binding]; other site 998820003761 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 998820003762 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 998820003763 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 998820003764 E3 interaction surface; other site 998820003765 lipoyl attachment site [posttranslational modification]; other site 998820003766 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 998820003767 E3 interaction surface; other site 998820003768 lipoyl attachment site [posttranslational modification]; other site 998820003769 e3 binding domain; Region: E3_binding; pfam02817 998820003770 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 998820003771 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 998820003772 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 998820003773 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 998820003774 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 998820003775 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 998820003776 NAD(P) binding site [chemical binding]; other site 998820003777 substrate binding site [chemical binding]; other site 998820003778 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 998820003779 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 998820003780 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 998820003781 active site 998820003782 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 998820003783 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 998820003784 G1 box; other site 998820003785 putative GEF interaction site [polypeptide binding]; other site 998820003786 GTP/Mg2+ binding site [chemical binding]; other site 998820003787 Switch I region; other site 998820003788 G2 box; other site 998820003789 G3 box; other site 998820003790 Switch II region; other site 998820003791 G4 box; other site 998820003792 G5 box; other site 998820003793 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 998820003794 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 998820003795 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 998820003796 pyruvate carboxylase; Reviewed; Region: PRK12999 998820003797 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 998820003798 ATP-grasp domain; Region: ATP-grasp_4; cl17255 998820003799 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 998820003800 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 998820003801 active site 998820003802 catalytic residues [active] 998820003803 metal binding site [ion binding]; metal-binding site 998820003804 homodimer binding site [polypeptide binding]; other site 998820003805 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 998820003806 carboxyltransferase (CT) interaction site; other site 998820003807 biotinylation site [posttranslational modification]; other site 998820003808 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 998820003809 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 998820003810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 998820003811 S-adenosylmethionine binding site [chemical binding]; other site 998820003812 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 998820003813 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 998820003814 active site 998820003815 (T/H)XGH motif; other site 998820003816 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 998820003817 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 998820003818 protein binding site [polypeptide binding]; other site 998820003819 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 998820003820 SLBB domain; Region: SLBB; pfam10531 998820003821 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 998820003822 Helix-hairpin-helix motif; Region: HHH; pfam00633 998820003823 Competence protein; Region: Competence; pfam03772 998820003824 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 998820003825 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 998820003826 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 998820003827 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 998820003828 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 998820003829 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 998820003830 16S/18S rRNA binding site [nucleotide binding]; other site 998820003831 S13e-L30e interaction site [polypeptide binding]; other site 998820003832 25S rRNA binding site [nucleotide binding]; other site 998820003833 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 998820003834 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 998820003835 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 998820003836 elongation factor Tu; Reviewed; Region: PRK00049 998820003837 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 998820003838 G1 box; other site 998820003839 GEF interaction site [polypeptide binding]; other site 998820003840 GTP/Mg2+ binding site [chemical binding]; other site 998820003841 Switch I region; other site 998820003842 G2 box; other site 998820003843 G3 box; other site 998820003844 Switch II region; other site 998820003845 G4 box; other site 998820003846 G5 box; other site 998820003847 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 998820003848 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 998820003849 Antibiotic Binding Site [chemical binding]; other site 998820003850 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 998820003851 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 998820003852 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 998820003853 Walker A/P-loop; other site 998820003854 ATP binding site [chemical binding]; other site 998820003855 Q-loop/lid; other site 998820003856 ABC transporter signature motif; other site 998820003857 Walker B; other site 998820003858 D-loop; other site 998820003859 H-loop/switch region; other site 998820003860 trigger factor; Provisional; Region: tig; PRK01490 998820003861 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 998820003862 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 998820003863 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 998820003864 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 998820003865 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 998820003866 Walker A motif; other site 998820003867 ATP binding site [chemical binding]; other site 998820003868 Walker B motif; other site 998820003869 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 998820003870 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 998820003871 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 998820003872 G1 box; other site 998820003873 GTP/Mg2+ binding site [chemical binding]; other site 998820003874 Switch I region; other site 998820003875 G2 box; other site 998820003876 G3 box; other site 998820003877 Switch II region; other site 998820003878 G4 box; other site 998820003879 G5 box; other site 998820003880 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 998820003881 putative metal binding site [ion binding]; other site 998820003882 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 998820003883 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 998820003884 substrate binding pocket [chemical binding]; other site 998820003885 membrane-bound complex binding site; other site 998820003886 hinge residues; other site 998820003887 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 998820003888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820003889 dimer interface [polypeptide binding]; other site 998820003890 conserved gate region; other site 998820003891 putative PBP binding loops; other site 998820003892 ABC-ATPase subunit interface; other site 998820003893 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 998820003894 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 998820003895 Walker A/P-loop; other site 998820003896 ATP binding site [chemical binding]; other site 998820003897 Q-loop/lid; other site 998820003898 ABC transporter signature motif; other site 998820003899 Walker B; other site 998820003900 D-loop; other site 998820003901 H-loop/switch region; other site 998820003902 Pleckstrin homology-like domain; Region: PH-like; cl17171 998820003903 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 998820003904 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 998820003905 GIY-YIG motif/motif A; other site 998820003906 active site 998820003907 catalytic site [active] 998820003908 putative DNA binding site [nucleotide binding]; other site 998820003909 metal binding site [ion binding]; metal-binding site 998820003910 UvrB/uvrC motif; Region: UVR; pfam02151 998820003911 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 998820003912 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 998820003913 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 998820003914 active site 998820003915 phosphorylation site [posttranslational modification] 998820003916 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 998820003917 active site 998820003918 P-loop; other site 998820003919 phosphorylation site [posttranslational modification] 998820003920 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 998820003921 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 998820003922 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 998820003923 putative substrate binding site [chemical binding]; other site 998820003924 putative ATP binding site [chemical binding]; other site 998820003925 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 998820003926 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 998820003927 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 998820003928 GTPase CgtA; Reviewed; Region: obgE; PRK12297 998820003929 GTP1/OBG; Region: GTP1_OBG; pfam01018 998820003930 Obg GTPase; Region: Obg; cd01898 998820003931 G1 box; other site 998820003932 GTP/Mg2+ binding site [chemical binding]; other site 998820003933 Switch I region; other site 998820003934 G2 box; other site 998820003935 G3 box; other site 998820003936 Switch II region; other site 998820003937 G4 box; other site 998820003938 G5 box; other site 998820003939 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 998820003940 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 998820003941 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 998820003942 catalytic triad [active] 998820003943 catalytic triad [active] 998820003944 oxyanion hole [active] 998820003945 ribonuclease Z; Region: RNase_Z; TIGR02651 998820003946 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 998820003947 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 998820003948 NAD(P) binding site [chemical binding]; other site 998820003949 active site 998820003950 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 998820003951 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 998820003952 Clp amino terminal domain; Region: Clp_N; pfam02861 998820003953 Clp amino terminal domain; Region: Clp_N; pfam02861 998820003954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 998820003955 Walker A motif; other site 998820003956 ATP binding site [chemical binding]; other site 998820003957 Walker B motif; other site 998820003958 arginine finger; other site 998820003959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 998820003960 Walker A motif; other site 998820003961 ATP binding site [chemical binding]; other site 998820003962 Walker B motif; other site 998820003963 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 998820003964 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 998820003965 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 998820003966 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 998820003967 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 998820003968 active site 998820003969 metal binding site [ion binding]; metal-binding site 998820003970 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 998820003971 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 998820003972 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 998820003973 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 998820003974 active site 998820003975 PHP Thumb interface [polypeptide binding]; other site 998820003976 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 998820003977 generic binding surface I; other site 998820003978 generic binding surface II; other site 998820003979 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 998820003980 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 998820003981 active site 998820003982 ADP/pyrophosphate binding site [chemical binding]; other site 998820003983 dimerization interface [polypeptide binding]; other site 998820003984 allosteric effector site; other site 998820003985 fructose-1,6-bisphosphate binding site; other site 998820003986 pyruvate kinase; Provisional; Region: PRK06354 998820003987 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 998820003988 domain interfaces; other site 998820003989 active site 998820003990 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 998820003991 Protein of unknown function (DUF441); Region: DUF441; pfam04284 998820003992 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 998820003993 S1 domain; Region: S1_2; pfam13509 998820003994 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 998820003995 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 998820003996 active site 998820003997 Int/Topo IB signature motif; other site 998820003998 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 998820003999 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 998820004000 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 998820004001 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 998820004002 RNA binding surface [nucleotide binding]; other site 998820004003 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 998820004004 active site 998820004005 Predicted membrane protein [Function unknown]; Region: COG3601 998820004006 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 998820004007 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 998820004008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 998820004009 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 998820004010 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 998820004011 ATP binding site [chemical binding]; other site 998820004012 putative Mg++ binding site [ion binding]; other site 998820004013 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 998820004014 nucleotide binding region [chemical binding]; other site 998820004015 ATP-binding site [chemical binding]; other site 998820004016 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 998820004017 cytidylate kinase; Provisional; Region: cmk; PRK00023 998820004018 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 998820004019 CMP-binding site; other site 998820004020 The sites determining sugar specificity; other site 998820004021 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 998820004022 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 998820004023 RNA binding site [nucleotide binding]; other site 998820004024 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 998820004025 RNA binding site [nucleotide binding]; other site 998820004026 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 998820004027 RNA binding site [nucleotide binding]; other site 998820004028 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 998820004029 RNA binding site [nucleotide binding]; other site 998820004030 GTP-binding protein Der; Reviewed; Region: PRK00093 998820004031 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 998820004032 G1 box; other site 998820004033 GTP/Mg2+ binding site [chemical binding]; other site 998820004034 Switch I region; other site 998820004035 G2 box; other site 998820004036 Switch II region; other site 998820004037 G3 box; other site 998820004038 G4 box; other site 998820004039 G5 box; other site 998820004040 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 998820004041 G1 box; other site 998820004042 GTP/Mg2+ binding site [chemical binding]; other site 998820004043 Switch I region; other site 998820004044 G2 box; other site 998820004045 G3 box; other site 998820004046 Switch II region; other site 998820004047 G4 box; other site 998820004048 G5 box; other site 998820004049 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 998820004050 IHF dimer interface [polypeptide binding]; other site 998820004051 IHF - DNA interface [nucleotide binding]; other site 998820004052 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 998820004053 TPR motif; other site 998820004054 binding surface 998820004055 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 998820004056 binding surface 998820004057 TPR motif; other site 998820004058 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 998820004059 binding surface 998820004060 TPR motif; other site 998820004061 TPR repeat; Region: TPR_11; pfam13414 998820004062 Uncharacterized conserved protein [Function unknown]; Region: COG1284 998820004063 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 998820004064 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 998820004065 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 998820004066 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 998820004067 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 998820004068 active site 998820004069 NTP binding site [chemical binding]; other site 998820004070 metal binding triad [ion binding]; metal-binding site 998820004071 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 998820004072 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 998820004073 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 998820004074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820004075 Walker A/P-loop; other site 998820004076 ATP binding site [chemical binding]; other site 998820004077 Q-loop/lid; other site 998820004078 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 998820004079 ABC transporter signature motif; other site 998820004080 Walker B; other site 998820004081 D-loop; other site 998820004082 ABC transporter; Region: ABC_tran_2; pfam12848 998820004083 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 998820004084 thymidylate synthase; Region: thym_sym; TIGR03284 998820004085 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 998820004086 dimerization interface [polypeptide binding]; other site 998820004087 active site 998820004088 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 998820004089 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 998820004090 folate binding site [chemical binding]; other site 998820004091 NADP+ binding site [chemical binding]; other site 998820004092 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 998820004093 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 998820004094 EDD domain protein, DegV family; Region: DegV; TIGR00762 998820004095 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 998820004096 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 998820004097 active site 998820004098 catalytic triad [active] 998820004099 oxyanion hole [active] 998820004100 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 998820004101 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 998820004102 hypothetical protein; Provisional; Region: PRK13672 998820004103 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 998820004104 C-terminal peptidase (prc); Region: prc; TIGR00225 998820004105 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 998820004106 protein binding site [polypeptide binding]; other site 998820004107 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 998820004108 Catalytic dyad [active] 998820004109 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 998820004110 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 998820004111 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 998820004112 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 998820004113 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 998820004114 sequence-specific DNA binding site [nucleotide binding]; other site 998820004115 salt bridge; other site 998820004116 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 998820004117 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 998820004118 GTP/Mg2+ binding site [chemical binding]; other site 998820004119 G4 box; other site 998820004120 G5 box; other site 998820004121 G1 box; other site 998820004122 Switch I region; other site 998820004123 G2 box; other site 998820004124 G3 box; other site 998820004125 Switch II region; other site 998820004126 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 998820004127 RNA/DNA hybrid binding site [nucleotide binding]; other site 998820004128 active site 998820004129 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 998820004130 DNA protecting protein DprA; Region: dprA; TIGR00732 998820004131 DNA topoisomerase I; Validated; Region: PRK05582 998820004132 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 998820004133 active site 998820004134 interdomain interaction site; other site 998820004135 putative metal-binding site [ion binding]; other site 998820004136 nucleotide binding site [chemical binding]; other site 998820004137 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 998820004138 domain I; other site 998820004139 DNA binding groove [nucleotide binding] 998820004140 phosphate binding site [ion binding]; other site 998820004141 domain II; other site 998820004142 domain III; other site 998820004143 nucleotide binding site [chemical binding]; other site 998820004144 catalytic site [active] 998820004145 domain IV; other site 998820004146 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 998820004147 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 998820004148 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 998820004149 Glucose inhibited division protein A; Region: GIDA; pfam01134 998820004150 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 998820004151 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 998820004152 active site 998820004153 Int/Topo IB signature motif; other site 998820004154 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 998820004155 active site 998820004156 HslU subunit interaction site [polypeptide binding]; other site 998820004157 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 998820004158 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 998820004159 Walker A motif; other site 998820004160 ATP binding site [chemical binding]; other site 998820004161 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 998820004162 Walker B motif; other site 998820004163 arginine finger; other site 998820004164 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 998820004165 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 998820004166 active site 998820004167 catalytic residues [active] 998820004168 membrane protein; Provisional; Region: PRK14392 998820004169 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 998820004170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 998820004171 Mg2+ binding site [ion binding]; other site 998820004172 G-X-G motif; other site 998820004173 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 998820004174 anchoring element; other site 998820004175 dimer interface [polypeptide binding]; other site 998820004176 ATP binding site [chemical binding]; other site 998820004177 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 998820004178 active site 998820004179 putative metal-binding site [ion binding]; other site 998820004180 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 998820004181 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 998820004182 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 998820004183 CAP-like domain; other site 998820004184 active site 998820004185 primary dimer interface [polypeptide binding]; other site 998820004186 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 998820004187 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 998820004188 Pyruvate formate lyase 1; Region: PFL1; cd01678 998820004189 coenzyme A binding site [chemical binding]; other site 998820004190 active site 998820004191 catalytic residues [active] 998820004192 glycine loop; other site 998820004193 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 998820004194 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 998820004195 FeS/SAM binding site; other site 998820004196 Transcriptional regulator [Transcription]; Region: LysR; COG0583 998820004197 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 998820004198 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 998820004199 dimerization interface [polypeptide binding]; other site 998820004200 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 998820004201 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 998820004202 DHHA2 domain; Region: DHHA2; pfam02833 998820004203 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 998820004204 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 998820004205 active site 998820004206 DNA binding site [nucleotide binding] 998820004207 Int/Topo IB signature motif; other site 998820004208 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 998820004209 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 998820004210 Walker A/P-loop; other site 998820004211 ATP binding site [chemical binding]; other site 998820004212 Q-loop/lid; other site 998820004213 ABC transporter signature motif; other site 998820004214 Walker B; other site 998820004215 D-loop; other site 998820004216 H-loop/switch region; other site 998820004217 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 998820004218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 998820004219 ATP binding site [chemical binding]; other site 998820004220 Mg2+ binding site [ion binding]; other site 998820004221 G-X-G motif; other site 998820004222 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 998820004223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 998820004224 active site 998820004225 phosphorylation site [posttranslational modification] 998820004226 intermolecular recognition site; other site 998820004227 dimerization interface [polypeptide binding]; other site 998820004228 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 998820004229 DNA binding site [nucleotide binding] 998820004230 H+ Antiporter protein; Region: 2A0121; TIGR00900 998820004231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820004232 putative substrate translocation pore; other site 998820004233 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 998820004234 Coenzyme A binding pocket [chemical binding]; other site 998820004235 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 998820004236 dimer interface [polypeptide binding]; other site 998820004237 FMN binding site [chemical binding]; other site 998820004238 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 998820004239 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 998820004240 pyridoxal 5'-phosphate binding site [chemical binding]; other site 998820004241 homodimer interface [polypeptide binding]; other site 998820004242 catalytic residue [active] 998820004243 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 998820004244 metal binding site [ion binding]; metal-binding site 998820004245 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 998820004246 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 998820004247 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 998820004248 substrate binding site [chemical binding]; other site 998820004249 glutamase interaction surface [polypeptide binding]; other site 998820004250 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 998820004251 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 998820004252 catalytic residues [active] 998820004253 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 998820004254 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 998820004255 putative active site [active] 998820004256 oxyanion strand; other site 998820004257 catalytic triad [active] 998820004258 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 998820004259 4-fold oligomerization interface [polypeptide binding]; other site 998820004260 putative active site pocket [active] 998820004261 metal binding residues [ion binding]; metal-binding site 998820004262 3-fold/trimer interface [polypeptide binding]; other site 998820004263 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 998820004264 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 998820004265 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 998820004266 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 998820004267 dimer interface [polypeptide binding]; other site 998820004268 motif 1; other site 998820004269 active site 998820004270 motif 2; other site 998820004271 motif 3; other site 998820004272 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 998820004273 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 998820004274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 998820004275 homodimer interface [polypeptide binding]; other site 998820004276 catalytic residue [active] 998820004277 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 998820004278 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 998820004279 dimer interface [polypeptide binding]; other site 998820004280 ADP-ribose binding site [chemical binding]; other site 998820004281 active site 998820004282 nudix motif; other site 998820004283 metal binding site [ion binding]; metal-binding site 998820004284 EDD domain protein, DegV family; Region: DegV; TIGR00762 998820004285 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 998820004286 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 998820004287 Domain of unknown function (DUF814); Region: DUF814; pfam05670 998820004288 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Sulfolobus solfataricus (Ss) and its homologs from archaea and bacteria; Region: NTP-PPase_SsMazG; cd11535 998820004289 metal binding site [ion binding]; metal-binding site 998820004290 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 998820004291 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 998820004292 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 998820004293 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 998820004294 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 998820004295 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 998820004296 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 998820004297 E3 interaction surface; other site 998820004298 lipoyl attachment site [posttranslational modification]; other site 998820004299 e3 binding domain; Region: E3_binding; pfam02817 998820004300 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 998820004301 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 998820004302 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 998820004303 alpha subunit interface [polypeptide binding]; other site 998820004304 TPP binding site [chemical binding]; other site 998820004305 heterodimer interface [polypeptide binding]; other site 998820004306 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 998820004307 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 998820004308 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 998820004309 tetramer interface [polypeptide binding]; other site 998820004310 TPP-binding site [chemical binding]; other site 998820004311 heterodimer interface [polypeptide binding]; other site 998820004312 phosphorylation loop region [posttranslational modification] 998820004313 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 998820004314 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 998820004315 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 998820004316 butyrate kinase; Provisional; Region: PRK03011 998820004317 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 998820004318 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 998820004319 active site 998820004320 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 998820004321 active site 998820004322 dimer interface [polypeptide binding]; other site 998820004323 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 998820004324 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 998820004325 heterodimer interface [polypeptide binding]; other site 998820004326 active site 998820004327 FMN binding site [chemical binding]; other site 998820004328 homodimer interface [polypeptide binding]; other site 998820004329 substrate binding site [chemical binding]; other site 998820004330 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 998820004331 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 998820004332 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 998820004333 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 998820004334 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 998820004335 ATP-grasp domain; Region: ATP-grasp_4; cl17255 998820004336 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 998820004337 IMP binding site; other site 998820004338 dimer interface [polypeptide binding]; other site 998820004339 interdomain contacts; other site 998820004340 partial ornithine binding site; other site 998820004341 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 998820004342 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 998820004343 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 998820004344 catalytic site [active] 998820004345 subunit interface [polypeptide binding]; other site 998820004346 dihydroorotase; Validated; Region: pyrC; PRK09357 998820004347 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 998820004348 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 998820004349 active site 998820004350 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 998820004351 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 998820004352 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 998820004353 uracil transporter; Provisional; Region: PRK10720 998820004354 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 998820004355 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 998820004356 active site 998820004357 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 998820004358 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 998820004359 RNA binding surface [nucleotide binding]; other site 998820004360 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 998820004361 active site 998820004362 lipoprotein signal peptidase; Provisional; Region: PRK14797 998820004363 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 998820004364 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 998820004365 Potassium binding sites [ion binding]; other site 998820004366 Cesium cation binding sites [ion binding]; other site 998820004367 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 998820004368 RNA/DNA hybrid binding site [nucleotide binding]; other site 998820004369 active site 998820004370 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 998820004371 dimer interface [polypeptide binding]; other site 998820004372 FMN binding site [chemical binding]; other site 998820004373 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 998820004374 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 998820004375 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 998820004376 putative active site [active] 998820004377 catalytic site [active] 998820004378 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 998820004379 putative active site [active] 998820004380 catalytic site [active] 998820004381 Mga helix-turn-helix domain; Region: Mga; pfam05043 998820004382 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 998820004383 catalytic residues [active] 998820004384 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 998820004385 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 998820004386 Class I ribonucleotide reductase; Region: RNR_I; cd01679 998820004387 active site 998820004388 dimer interface [polypeptide binding]; other site 998820004389 catalytic residues [active] 998820004390 effector binding site; other site 998820004391 R2 peptide binding site; other site 998820004392 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 998820004393 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 998820004394 dimer interface [polypeptide binding]; other site 998820004395 putative radical transfer pathway; other site 998820004396 diiron center [ion binding]; other site 998820004397 tyrosyl radical; other site 998820004398 Transcriptional regulator [Transcription]; Region: LysR; COG0583 998820004399 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 998820004400 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 998820004401 dimerization interface [polypeptide binding]; other site 998820004402 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 998820004403 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 998820004404 active site 998820004405 Zn binding site [ion binding]; other site 998820004406 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 998820004407 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 998820004408 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 998820004409 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 998820004410 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 998820004411 putative ligand binding site [chemical binding]; other site 998820004412 NAD binding site [chemical binding]; other site 998820004413 catalytic site [active] 998820004414 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 998820004415 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 998820004416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 998820004417 cell division protein GpsB; Provisional; Region: PRK14127 998820004418 DivIVA domain; Region: DivI1A_domain; TIGR03544 998820004419 hypothetical protein; Provisional; Region: PRK13660 998820004420 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 998820004421 Transglycosylase; Region: Transgly; pfam00912 998820004422 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 998820004423 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 998820004424 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 998820004425 catalytic motif [active] 998820004426 Zn binding site [ion binding]; other site 998820004427 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 998820004428 endonuclease III; Region: ENDO3c; smart00478 998820004429 minor groove reading motif; other site 998820004430 helix-hairpin-helix signature motif; other site 998820004431 substrate binding pocket [chemical binding]; other site 998820004432 active site 998820004433 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 998820004434 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 998820004435 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 998820004436 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 998820004437 putative dimer interface [polypeptide binding]; other site 998820004438 putative anticodon binding site; other site 998820004439 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 998820004440 homodimer interface [polypeptide binding]; other site 998820004441 motif 1; other site 998820004442 motif 2; other site 998820004443 active site 998820004444 motif 3; other site 998820004445 aspartate aminotransferase; Provisional; Region: PRK05764 998820004446 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 998820004447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 998820004448 homodimer interface [polypeptide binding]; other site 998820004449 catalytic residue [active] 998820004450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 998820004451 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 998820004452 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 998820004453 active site 998820004454 catalytic site [active] 998820004455 substrate binding site [chemical binding]; other site 998820004456 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 998820004457 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 998820004458 DEAD/DEAH box helicase; Region: DEAD; pfam00270 998820004459 ATP binding site [chemical binding]; other site 998820004460 Family description; Region: UvrD_C_2; pfam13538 998820004461 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 998820004462 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 998820004463 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 998820004464 mevalonate kinase; Region: mevalon_kin; TIGR00549 998820004465 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 998820004466 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 998820004467 diphosphomevalonate decarboxylase; Region: PLN02407 998820004468 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 998820004469 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 998820004470 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 998820004471 homotetramer interface [polypeptide binding]; other site 998820004472 FMN binding site [chemical binding]; other site 998820004473 homodimer contacts [polypeptide binding]; other site 998820004474 putative active site [active] 998820004475 putative substrate binding site [chemical binding]; other site 998820004476 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 998820004477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 998820004478 S-adenosylmethionine binding site [chemical binding]; other site 998820004479 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 998820004480 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 998820004481 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 998820004482 active site 1 [active] 998820004483 dimer interface [polypeptide binding]; other site 998820004484 hexamer interface [polypeptide binding]; other site 998820004485 active site 2 [active] 998820004486 Uncharacterized conserved protein [Function unknown]; Region: COG0327 998820004487 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 998820004488 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 998820004489 Family of unknown function (DUF633); Region: DUF633; pfam04816 998820004490 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 998820004491 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 998820004492 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 998820004493 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 998820004494 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 998820004495 DNA binding residues [nucleotide binding] 998820004496 DNA primase; Validated; Region: dnaG; PRK05667 998820004497 CHC2 zinc finger; Region: zf-CHC2; pfam01807 998820004498 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 998820004499 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 998820004500 active site 998820004501 metal binding site [ion binding]; metal-binding site 998820004502 interdomain interaction site; other site 998820004503 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 998820004504 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 998820004505 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 998820004506 dimer interface [polypeptide binding]; other site 998820004507 motif 1; other site 998820004508 active site 998820004509 motif 2; other site 998820004510 motif 3; other site 998820004511 Recombination protein O N terminal; Region: RecO_N; pfam11967 998820004512 DNA repair protein RecO; Region: reco; TIGR00613 998820004513 Recombination protein O C terminal; Region: RecO_C; pfam02565 998820004514 GTPase Era; Reviewed; Region: era; PRK00089 998820004515 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 998820004516 G1 box; other site 998820004517 GTP/Mg2+ binding site [chemical binding]; other site 998820004518 Switch I region; other site 998820004519 G2 box; other site 998820004520 Switch II region; other site 998820004521 G3 box; other site 998820004522 G4 box; other site 998820004523 G5 box; other site 998820004524 KH domain; Region: KH_2; pfam07650 998820004525 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 998820004526 active site 998820004527 catalytic motif [active] 998820004528 Zn binding site [ion binding]; other site 998820004529 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 998820004530 metal-binding heat shock protein; Provisional; Region: PRK00016 998820004531 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 998820004532 PhoH-like protein; Region: PhoH; pfam02562 998820004533 Yqey-like protein; Region: YqeY; pfam09424 998820004534 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 998820004535 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 998820004536 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 998820004537 endonuclease IV; Provisional; Region: PRK01060 998820004538 AP (apurinic/apyrimidinic) site pocket; other site 998820004539 DNA interaction; other site 998820004540 Metal-binding active site; metal-binding site 998820004541 Uncharacterized conserved protein [Function unknown]; Region: COG1284 998820004542 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 998820004543 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 998820004544 methionine sulfoxide reductase B; Provisional; Region: PRK00222 998820004545 SelR domain; Region: SelR; pfam01641 998820004546 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 998820004547 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 998820004548 dimer interface [polypeptide binding]; other site 998820004549 anticodon binding site; other site 998820004550 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 998820004551 homodimer interface [polypeptide binding]; other site 998820004552 motif 1; other site 998820004553 active site 998820004554 motif 2; other site 998820004555 GAD domain; Region: GAD; pfam02938 998820004556 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 998820004557 motif 3; other site 998820004558 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 998820004559 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 998820004560 dimer interface [polypeptide binding]; other site 998820004561 motif 1; other site 998820004562 active site 998820004563 motif 2; other site 998820004564 motif 3; other site 998820004565 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 998820004566 anticodon binding site; other site 998820004567 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 998820004568 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 998820004569 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 998820004570 putative NAD(P) binding site [chemical binding]; other site 998820004571 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 998820004572 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 998820004573 non-specific DNA binding site [nucleotide binding]; other site 998820004574 salt bridge; other site 998820004575 sequence-specific DNA binding site [nucleotide binding]; other site 998820004576 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 998820004577 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 998820004578 Walker A/P-loop; other site 998820004579 ATP binding site [chemical binding]; other site 998820004580 Q-loop/lid; other site 998820004581 ABC transporter signature motif; other site 998820004582 Walker B; other site 998820004583 D-loop; other site 998820004584 H-loop/switch region; other site 998820004585 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 998820004586 Bacterial SH3 domain; Region: SH3_3; pfam08239 998820004587 Bacterial SH3 domain; Region: SH3_3; pfam08239 998820004588 Bacterial SH3 domain homologues; Region: SH3b; smart00287 998820004589 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 998820004590 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 998820004591 active site 998820004592 metal binding site [ion binding]; metal-binding site 998820004593 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 998820004594 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820004595 motif II; other site 998820004596 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 998820004597 putative active site [active] 998820004598 dimerization interface [polypeptide binding]; other site 998820004599 putative tRNAtyr binding site [nucleotide binding]; other site 998820004600 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 998820004601 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 998820004602 Zn2+ binding site [ion binding]; other site 998820004603 Mg2+ binding site [ion binding]; other site 998820004604 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 998820004605 synthetase active site [active] 998820004606 NTP binding site [chemical binding]; other site 998820004607 metal binding site [ion binding]; metal-binding site 998820004608 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 998820004609 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 998820004610 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 998820004611 RNA methyltransferase, RsmE family; Region: TIGR00046 998820004612 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 998820004613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 998820004614 S-adenosylmethionine binding site [chemical binding]; other site 998820004615 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 998820004616 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 998820004617 active site 998820004618 DNA binding site [nucleotide binding] 998820004619 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 998820004620 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 998820004621 Coenzyme A binding pocket [chemical binding]; other site 998820004622 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 998820004623 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 998820004624 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 998820004625 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 998820004626 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 998820004627 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 998820004628 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 998820004629 putative deacylase active site [active] 998820004630 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 998820004631 active site 998820004632 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 998820004633 DHH family; Region: DHH; pfam01368 998820004634 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 998820004635 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 998820004636 GTP-binding protein LepA; Provisional; Region: PRK05433 998820004637 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 998820004638 G1 box; other site 998820004639 putative GEF interaction site [polypeptide binding]; other site 998820004640 GTP/Mg2+ binding site [chemical binding]; other site 998820004641 Switch I region; other site 998820004642 G2 box; other site 998820004643 G3 box; other site 998820004644 Switch II region; other site 998820004645 G4 box; other site 998820004646 G5 box; other site 998820004647 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 998820004648 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 998820004649 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 998820004650 chaperone protein DnaJ; Provisional; Region: PRK14276 998820004651 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 998820004652 HSP70 interaction site [polypeptide binding]; other site 998820004653 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 998820004654 substrate binding site [polypeptide binding]; other site 998820004655 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 998820004656 Zn binding sites [ion binding]; other site 998820004657 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 998820004658 dimer interface [polypeptide binding]; other site 998820004659 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 998820004660 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 998820004661 nucleotide binding site [chemical binding]; other site 998820004662 NEF interaction site [polypeptide binding]; other site 998820004663 SBD interface [polypeptide binding]; other site 998820004664 GrpE; Region: GrpE; pfam01025 998820004665 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 998820004666 dimer interface [polypeptide binding]; other site 998820004667 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 998820004668 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 998820004669 HTH domain; Region: HTH_11; pfam08279 998820004670 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 998820004671 HemN C-terminal domain; Region: HemN_C; pfam06969 998820004672 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 998820004673 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 998820004674 active site 998820004675 Riboflavin kinase; Region: Flavokinase; smart00904 998820004676 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 998820004677 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 998820004678 RNA binding site [nucleotide binding]; other site 998820004679 active site 998820004680 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 998820004681 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 998820004682 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 998820004683 translation initiation factor IF-2; Region: IF-2; TIGR00487 998820004684 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 998820004685 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 998820004686 G1 box; other site 998820004687 putative GEF interaction site [polypeptide binding]; other site 998820004688 GTP/Mg2+ binding site [chemical binding]; other site 998820004689 Switch I region; other site 998820004690 G2 box; other site 998820004691 G3 box; other site 998820004692 Switch II region; other site 998820004693 G4 box; other site 998820004694 G5 box; other site 998820004695 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 998820004696 Translation-initiation factor 2; Region: IF-2; pfam11987 998820004697 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 998820004698 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 998820004699 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 998820004700 putative RNA binding cleft [nucleotide binding]; other site 998820004701 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 998820004702 NusA N-terminal domain; Region: NusA_N; pfam08529 998820004703 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 998820004704 RNA binding site [nucleotide binding]; other site 998820004705 homodimer interface [polypeptide binding]; other site 998820004706 NusA-like KH domain; Region: KH_5; pfam13184 998820004707 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 998820004708 G-X-X-G motif; other site 998820004709 ribosome maturation protein RimP; Reviewed; Region: PRK00092 998820004710 Sm and related proteins; Region: Sm_like; cl00259 998820004711 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 998820004712 putative oligomer interface [polypeptide binding]; other site 998820004713 putative RNA binding site [nucleotide binding]; other site 998820004714 DNA polymerase III PolC; Validated; Region: polC; PRK00448 998820004715 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 998820004716 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 998820004717 generic binding surface II; other site 998820004718 generic binding surface I; other site 998820004719 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 998820004720 active site 998820004721 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 998820004722 active site 998820004723 catalytic site [active] 998820004724 substrate binding site [chemical binding]; other site 998820004725 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 998820004726 prolyl-tRNA synthetase; Provisional; Region: PRK09194 998820004727 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 998820004728 dimer interface [polypeptide binding]; other site 998820004729 motif 1; other site 998820004730 active site 998820004731 motif 2; other site 998820004732 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 998820004733 putative deacylase active site [active] 998820004734 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 998820004735 active site 998820004736 motif 3; other site 998820004737 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 998820004738 anticodon binding site; other site 998820004739 RIP metalloprotease RseP; Region: TIGR00054 998820004740 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 998820004741 active site 998820004742 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 998820004743 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 998820004744 protein binding site [polypeptide binding]; other site 998820004745 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 998820004746 putative substrate binding region [chemical binding]; other site 998820004747 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 998820004748 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 998820004749 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 998820004750 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 998820004751 catalytic residue [active] 998820004752 putative FPP diphosphate binding site; other site 998820004753 putative FPP binding hydrophobic cleft; other site 998820004754 dimer interface [polypeptide binding]; other site 998820004755 putative IPP diphosphate binding site; other site 998820004756 ribosome recycling factor; Reviewed; Region: frr; PRK00083 998820004757 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 998820004758 hinge region; other site 998820004759 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 998820004760 putative nucleotide binding site [chemical binding]; other site 998820004761 uridine monophosphate binding site [chemical binding]; other site 998820004762 homohexameric interface [polypeptide binding]; other site 998820004763 elongation factor Ts; Provisional; Region: tsf; PRK09377 998820004764 UBA/TS-N domain; Region: UBA; pfam00627 998820004765 Elongation factor TS; Region: EF_TS; pfam00889 998820004766 Elongation factor TS; Region: EF_TS; pfam00889 998820004767 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 998820004768 rRNA interaction site [nucleotide binding]; other site 998820004769 S8 interaction site; other site 998820004770 putative laminin-1 binding site; other site 998820004771 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 998820004772 GIY-YIG motif/motif A; other site 998820004773 putative active site [active] 998820004774 putative metal binding site [ion binding]; other site 998820004775 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 998820004776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 998820004777 S-adenosylmethionine binding site [chemical binding]; other site 998820004778 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 998820004779 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 998820004780 putative acyl-acceptor binding pocket; other site 998820004781 amino acid transporter; Region: 2A0306; TIGR00909 998820004782 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 998820004783 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 998820004784 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 998820004785 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 998820004786 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 998820004787 Walker A/P-loop; other site 998820004788 ATP binding site [chemical binding]; other site 998820004789 Q-loop/lid; other site 998820004790 ABC transporter signature motif; other site 998820004791 Walker B; other site 998820004792 D-loop; other site 998820004793 H-loop/switch region; other site 998820004794 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 998820004795 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 998820004796 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820004797 Walker A/P-loop; other site 998820004798 ATP binding site [chemical binding]; other site 998820004799 Q-loop/lid; other site 998820004800 ABC transporter signature motif; other site 998820004801 Walker B; other site 998820004802 D-loop; other site 998820004803 H-loop/switch region; other site 998820004804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 998820004805 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 998820004806 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 998820004807 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 998820004808 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 998820004809 RimM N-terminal domain; Region: RimM; pfam01782 998820004810 PRC-barrel domain; Region: PRC; pfam05239 998820004811 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 998820004812 KH domain; Region: KH_4; pfam13083 998820004813 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 998820004814 signal recognition particle protein; Provisional; Region: PRK10867 998820004815 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 998820004816 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 998820004817 P loop; other site 998820004818 GTP binding site [chemical binding]; other site 998820004819 Signal peptide binding domain; Region: SRP_SPB; pfam02978 998820004820 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 998820004821 putative DNA-binding protein; Validated; Region: PRK00118 998820004822 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 998820004823 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 998820004824 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 998820004825 P loop; other site 998820004826 GTP binding site [chemical binding]; other site 998820004827 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 998820004828 AAA domain; Region: AAA_23; pfam13476 998820004829 Walker A/P-loop; other site 998820004830 ATP binding site [chemical binding]; other site 998820004831 Q-loop/lid; other site 998820004832 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 998820004833 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 998820004834 ABC transporter signature motif; other site 998820004835 Walker B; other site 998820004836 D-loop; other site 998820004837 H-loop/switch region; other site 998820004838 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 998820004839 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 998820004840 dimerization interface [polypeptide binding]; other site 998820004841 active site 998820004842 metal binding site [ion binding]; metal-binding site 998820004843 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 998820004844 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 998820004845 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 998820004846 peptide binding site [polypeptide binding]; other site 998820004847 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 998820004848 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 998820004849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820004850 dimer interface [polypeptide binding]; other site 998820004851 conserved gate region; other site 998820004852 putative PBP binding loops; other site 998820004853 ABC-ATPase subunit interface; other site 998820004854 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 998820004855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820004856 dimer interface [polypeptide binding]; other site 998820004857 conserved gate region; other site 998820004858 putative PBP binding loops; other site 998820004859 ABC-ATPase subunit interface; other site 998820004860 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 998820004861 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 998820004862 Walker A/P-loop; other site 998820004863 ATP binding site [chemical binding]; other site 998820004864 Q-loop/lid; other site 998820004865 ABC transporter signature motif; other site 998820004866 Walker B; other site 998820004867 D-loop; other site 998820004868 H-loop/switch region; other site 998820004869 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 998820004870 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 998820004871 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 998820004872 Walker A/P-loop; other site 998820004873 ATP binding site [chemical binding]; other site 998820004874 Q-loop/lid; other site 998820004875 ABC transporter signature motif; other site 998820004876 Walker B; other site 998820004877 D-loop; other site 998820004878 H-loop/switch region; other site 998820004879 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 998820004880 acyl carrier protein; Provisional; Region: acpP; PRK00982 998820004881 putative phosphate acyltransferase; Provisional; Region: PRK05331 998820004882 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 998820004883 Y-family of DNA polymerases; Region: PolY; cl12025 998820004884 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 998820004885 generic binding surface II; other site 998820004886 ssDNA binding site; other site 998820004887 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 998820004888 ATP binding site [chemical binding]; other site 998820004889 putative Mg++ binding site [ion binding]; other site 998820004890 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 998820004891 nucleotide binding region [chemical binding]; other site 998820004892 ATP-binding site [chemical binding]; other site 998820004893 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 998820004894 DAK2 domain; Region: Dak2; pfam02734 998820004895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 998820004896 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 998820004897 Thiamine pyrophosphokinase; Region: TPK; cd07995 998820004898 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 998820004899 active site 998820004900 dimerization interface [polypeptide binding]; other site 998820004901 thiamine binding site [chemical binding]; other site 998820004902 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 998820004903 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 998820004904 substrate binding site [chemical binding]; other site 998820004905 hexamer interface [polypeptide binding]; other site 998820004906 metal binding site [ion binding]; metal-binding site 998820004907 GTPase RsgA; Reviewed; Region: PRK00098 998820004908 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 998820004909 RNA binding site [nucleotide binding]; other site 998820004910 homodimer interface [polypeptide binding]; other site 998820004911 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 998820004912 GTPase/Zn-binding domain interface [polypeptide binding]; other site 998820004913 GTP/Mg2+ binding site [chemical binding]; other site 998820004914 G4 box; other site 998820004915 G5 box; other site 998820004916 G1 box; other site 998820004917 Switch I region; other site 998820004918 G2 box; other site 998820004919 G3 box; other site 998820004920 Switch II region; other site 998820004921 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 998820004922 Catalytic domain of Protein Kinases; Region: PKc; cd00180 998820004923 active site 998820004924 ATP binding site [chemical binding]; other site 998820004925 substrate binding site [chemical binding]; other site 998820004926 activation loop (A-loop); other site 998820004927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 998820004928 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 998820004929 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 998820004930 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 998820004931 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 998820004932 active site 998820004933 16S rRNA methyltransferase B; Provisional; Region: PRK14902 998820004934 NusB family; Region: NusB; pfam01029 998820004935 putative RNA binding site [nucleotide binding]; other site 998820004936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 998820004937 S-adenosylmethionine binding site [chemical binding]; other site 998820004938 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 998820004939 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 998820004940 putative active site [active] 998820004941 substrate binding site [chemical binding]; other site 998820004942 putative cosubstrate binding site; other site 998820004943 catalytic site [active] 998820004944 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 998820004945 substrate binding site [chemical binding]; other site 998820004946 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 998820004947 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 998820004948 ATP binding site [chemical binding]; other site 998820004949 putative Mg++ binding site [ion binding]; other site 998820004950 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 998820004951 nucleotide binding region [chemical binding]; other site 998820004952 ATP-binding site [chemical binding]; other site 998820004953 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 998820004954 Flavoprotein; Region: Flavoprotein; pfam02441 998820004955 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 998820004956 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 998820004957 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 998820004958 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 998820004959 catalytic site [active] 998820004960 G-X2-G-X-G-K; other site 998820004961 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 998820004962 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 998820004963 nucleophile elbow; other site 998820004964 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 998820004965 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 998820004966 Walker A/P-loop; other site 998820004967 ATP binding site [chemical binding]; other site 998820004968 Q-loop/lid; other site 998820004969 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 998820004970 ABC transporter signature motif; other site 998820004971 Walker B; other site 998820004972 D-loop; other site 998820004973 H-loop/switch region; other site 998820004974 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 998820004975 arginine repressor; Provisional; Region: PRK04280 998820004976 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 998820004977 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 998820004978 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 998820004979 RNA binding surface [nucleotide binding]; other site 998820004980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 998820004981 S-adenosylmethionine binding site [chemical binding]; other site 998820004982 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 998820004983 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 998820004984 substrate binding pocket [chemical binding]; other site 998820004985 chain length determination region; other site 998820004986 substrate-Mg2+ binding site; other site 998820004987 catalytic residues [active] 998820004988 aspartate-rich region 1; other site 998820004989 active site lid residues [active] 998820004990 aspartate-rich region 2; other site 998820004991 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 998820004992 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 998820004993 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 998820004994 generic binding surface II; other site 998820004995 generic binding surface I; other site 998820004996 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14169 998820004997 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 998820004998 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 998820004999 homodimer interface [polypeptide binding]; other site 998820005000 NADP binding site [chemical binding]; other site 998820005001 substrate binding site [chemical binding]; other site 998820005002 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 998820005003 putative RNA binding site [nucleotide binding]; other site 998820005004 Asp23 family; Region: Asp23; pfam03780 998820005005 elongation factor P; Validated; Region: PRK00529 998820005006 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 998820005007 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 998820005008 RNA binding site [nucleotide binding]; other site 998820005009 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 998820005010 RNA binding site [nucleotide binding]; other site 998820005011 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 998820005012 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 998820005013 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 998820005014 active site 998820005015 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 998820005016 Protein of unknown function (DUF464); Region: DUF464; pfam04327 998820005017 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 998820005018 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 998820005019 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 998820005020 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 998820005021 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 998820005022 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 998820005023 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 998820005024 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 998820005025 DNA binding residues [nucleotide binding] 998820005026 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 998820005027 putative dimer interface [polypeptide binding]; other site 998820005028 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 998820005029 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 998820005030 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 998820005031 catalytic residue [active] 998820005032 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 998820005033 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 998820005034 Aluminium resistance protein; Region: Alum_res; pfam06838 998820005035 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 998820005036 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 998820005037 Helix-turn-helix domain; Region: HTH_38; pfam13936 998820005038 Integrase core domain; Region: rve; pfam00665 998820005039 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 998820005040 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 998820005041 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 998820005042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 998820005043 active site 998820005044 phosphorylation site [posttranslational modification] 998820005045 intermolecular recognition site; other site 998820005046 dimerization interface [polypeptide binding]; other site 998820005047 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 998820005048 DNA binding residues [nucleotide binding] 998820005049 dimerization interface [polypeptide binding]; other site 998820005050 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 998820005051 Histidine kinase; Region: HisKA_3; pfam07730 998820005052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 998820005053 ATP binding site [chemical binding]; other site 998820005054 Mg2+ binding site [ion binding]; other site 998820005055 G-X-G motif; other site 998820005056 Predicted membrane protein [Function unknown]; Region: COG4758 998820005057 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 998820005058 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 998820005059 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 998820005060 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 998820005061 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 998820005062 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 998820005063 ATP-binding site [chemical binding]; other site 998820005064 Sugar specificity; other site 998820005065 Pyrimidine base specificity; other site 998820005066 YceG-like family; Region: YceG; pfam02618 998820005067 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 998820005068 dimerization interface [polypeptide binding]; other site 998820005069 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 998820005070 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 998820005071 putative tRNA-binding site [nucleotide binding]; other site 998820005072 B3/4 domain; Region: B3_4; pfam03483 998820005073 tRNA synthetase B5 domain; Region: B5; smart00874 998820005074 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 998820005075 dimer interface [polypeptide binding]; other site 998820005076 motif 1; other site 998820005077 motif 3; other site 998820005078 motif 2; other site 998820005079 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 998820005080 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 998820005081 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 998820005082 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 998820005083 dimer interface [polypeptide binding]; other site 998820005084 motif 1; other site 998820005085 active site 998820005086 motif 2; other site 998820005087 motif 3; other site 998820005088 Predicted transcriptional regulators [Transcription]; Region: COG1733 998820005089 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 998820005090 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 998820005091 Zn2+ binding site [ion binding]; other site 998820005092 Mg2+ binding site [ion binding]; other site 998820005093 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 998820005094 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 998820005095 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 998820005096 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 998820005097 OxaA-like protein precursor; Provisional; Region: PRK02463 998820005098 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 998820005099 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 998820005100 HAMP domain; Region: HAMP; pfam00672 998820005101 dimerization interface [polypeptide binding]; other site 998820005102 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 998820005103 dimer interface [polypeptide binding]; other site 998820005104 phosphorylation site [posttranslational modification] 998820005105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 998820005106 ATP binding site [chemical binding]; other site 998820005107 Mg2+ binding site [ion binding]; other site 998820005108 G-X-G motif; other site 998820005109 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 998820005110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 998820005111 active site 998820005112 phosphorylation site [posttranslational modification] 998820005113 intermolecular recognition site; other site 998820005114 dimerization interface [polypeptide binding]; other site 998820005115 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 998820005116 DNA binding site [nucleotide binding] 998820005117 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 998820005118 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 998820005119 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 998820005120 Protein of unknown function (DUF3781); Region: DUF3781; pfam12636 998820005121 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 998820005122 hypothetical protein; Provisional; Region: PRK13670 998820005123 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 998820005124 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 998820005125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 998820005126 S-adenosylmethionine binding site [chemical binding]; other site 998820005127 Oligomerisation domain; Region: Oligomerisation; pfam02410 998820005128 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 998820005129 Zn2+ binding site [ion binding]; other site 998820005130 Mg2+ binding site [ion binding]; other site 998820005131 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 998820005132 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 998820005133 active site 998820005134 (T/H)XGH motif; other site 998820005135 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 998820005136 GTPase YqeH; Provisional; Region: PRK13796 998820005137 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 998820005138 GTP/Mg2+ binding site [chemical binding]; other site 998820005139 G4 box; other site 998820005140 G5 box; other site 998820005141 G1 box; other site 998820005142 Switch I region; other site 998820005143 G2 box; other site 998820005144 G3 box; other site 998820005145 Switch II region; other site 998820005146 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 998820005147 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820005148 active site 998820005149 motif I; other site 998820005150 motif II; other site 998820005151 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 998820005152 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 998820005153 Zn binding site [ion binding]; other site 998820005154 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 998820005155 Zn binding site [ion binding]; other site 998820005156 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 998820005157 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 998820005158 Zn binding site [ion binding]; other site 998820005159 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 998820005160 Zn binding site [ion binding]; other site 998820005161 Predicted esterase [General function prediction only]; Region: COG0400 998820005162 putative hydrolase; Provisional; Region: PRK11460 998820005163 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 998820005164 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 998820005165 putative NAD(P) binding site [chemical binding]; other site 998820005166 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 998820005167 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 998820005168 23S rRNA binding site [nucleotide binding]; other site 998820005169 L21 binding site [polypeptide binding]; other site 998820005170 L13 binding site [polypeptide binding]; other site 998820005171 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 998820005172 translation initiation factor IF-3; Region: infC; TIGR00168 998820005173 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 998820005174 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 998820005175 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 998820005176 catalytic core [active] 998820005177 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 998820005178 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 998820005179 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 998820005180 active site 998820005181 dimer interface [polypeptide binding]; other site 998820005182 motif 1; other site 998820005183 motif 2; other site 998820005184 motif 3; other site 998820005185 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 998820005186 anticodon binding site; other site 998820005187 primosomal protein DnaI; Reviewed; Region: PRK08939 998820005188 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 998820005189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 998820005190 Walker A motif; other site 998820005191 ATP binding site [chemical binding]; other site 998820005192 Walker B motif; other site 998820005193 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 998820005194 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 998820005195 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 998820005196 ATP cone domain; Region: ATP-cone; pfam03477 998820005197 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 998820005198 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 998820005199 CoA-binding site [chemical binding]; other site 998820005200 ATP-binding [chemical binding]; other site 998820005201 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 998820005202 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 998820005203 DNA binding site [nucleotide binding] 998820005204 catalytic residue [active] 998820005205 H2TH interface [polypeptide binding]; other site 998820005206 putative catalytic residues [active] 998820005207 turnover-facilitating residue; other site 998820005208 intercalation triad [nucleotide binding]; other site 998820005209 8OG recognition residue [nucleotide binding]; other site 998820005210 putative reading head residues; other site 998820005211 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 998820005212 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 998820005213 DNA polymerase I; Provisional; Region: PRK05755 998820005214 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 998820005215 active site 998820005216 metal binding site 1 [ion binding]; metal-binding site 998820005217 putative 5' ssDNA interaction site; other site 998820005218 metal binding site 3; metal-binding site 998820005219 metal binding site 2 [ion binding]; metal-binding site 998820005220 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 998820005221 putative DNA binding site [nucleotide binding]; other site 998820005222 putative metal binding site [ion binding]; other site 998820005223 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 998820005224 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 998820005225 active site 998820005226 DNA binding site [nucleotide binding] 998820005227 catalytic site [active] 998820005228 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 998820005229 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 998820005230 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 998820005231 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 998820005232 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 998820005233 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 998820005234 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 998820005235 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 998820005236 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 998820005237 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 998820005238 putative tRNA-binding site [nucleotide binding]; other site 998820005239 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 998820005240 catalytic residues [active] 998820005241 Predicted small secreted protein [Function unknown]; Region: COG5584 998820005242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 998820005243 S-adenosylmethionine binding site [chemical binding]; other site 998820005244 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 998820005245 Phosphotransferase enzyme family; Region: APH; pfam01636 998820005246 substrate binding site [chemical binding]; other site 998820005247 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 998820005248 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 998820005249 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 998820005250 Walker A/P-loop; other site 998820005251 ATP binding site [chemical binding]; other site 998820005252 Q-loop/lid; other site 998820005253 ABC transporter signature motif; other site 998820005254 Walker B; other site 998820005255 D-loop; other site 998820005256 H-loop/switch region; other site 998820005257 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 998820005258 HIT family signature motif; other site 998820005259 catalytic residue [active] 998820005260 YtxH-like protein; Region: YtxH; pfam12732 998820005261 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 998820005262 SurA N-terminal domain; Region: SurA_N_3; cl07813 998820005263 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 998820005264 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 998820005265 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 998820005266 generic binding surface I; other site 998820005267 generic binding surface II; other site 998820005268 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 998820005269 Zn2+ binding site [ion binding]; other site 998820005270 Mg2+ binding site [ion binding]; other site 998820005271 Protein of unknown function (DUF964); Region: DUF964; cl01483 998820005272 Transglycosylase; Region: Transgly; pfam00912 998820005273 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 998820005274 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 998820005275 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 998820005276 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 998820005277 active site 998820005278 Arginine repressor [Transcription]; Region: ArgR; COG1438 998820005279 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 998820005280 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 998820005281 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 998820005282 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 998820005283 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 998820005284 active site 998820005285 HIGH motif; other site 998820005286 KMSK motif region; other site 998820005287 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 998820005288 tRNA binding surface [nucleotide binding]; other site 998820005289 anticodon binding site; other site 998820005290 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 998820005291 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 998820005292 active site 998820005293 FMN binding site [chemical binding]; other site 998820005294 substrate binding site [chemical binding]; other site 998820005295 catalytic residues [active] 998820005296 homodimer interface [polypeptide binding]; other site 998820005297 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 998820005298 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 998820005299 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 998820005300 putative active site [active] 998820005301 catalytic site [active] 998820005302 putative metal binding site [ion binding]; other site 998820005303 adaptor protein; Provisional; Region: PRK02315 998820005304 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 998820005305 ArsC family; Region: ArsC; pfam03960 998820005306 putative catalytic residues [active] 998820005307 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 998820005308 FtsX-like permease family; Region: FtsX; pfam02687 998820005309 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 998820005310 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 998820005311 Walker A/P-loop; other site 998820005312 ATP binding site [chemical binding]; other site 998820005313 Q-loop/lid; other site 998820005314 ABC transporter signature motif; other site 998820005315 Walker B; other site 998820005316 D-loop; other site 998820005317 H-loop/switch region; other site 998820005318 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 998820005319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 998820005320 active site 998820005321 phosphorylation site [posttranslational modification] 998820005322 intermolecular recognition site; other site 998820005323 dimerization interface [polypeptide binding]; other site 998820005324 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 998820005325 DNA binding site [nucleotide binding] 998820005326 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 998820005327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 998820005328 ATP binding site [chemical binding]; other site 998820005329 Mg2+ binding site [ion binding]; other site 998820005330 G-X-G motif; other site 998820005331 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 998820005332 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 998820005333 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 998820005334 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 998820005335 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 998820005336 Penicillinase repressor; Region: Pencillinase_R; pfam03965 998820005337 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 998820005338 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 998820005339 ATP-grasp domain; Region: ATP-grasp_4; cl17255 998820005340 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 998820005341 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 998820005342 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 998820005343 purine monophosphate binding site [chemical binding]; other site 998820005344 dimer interface [polypeptide binding]; other site 998820005345 putative catalytic residues [active] 998820005346 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 998820005347 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 998820005348 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 998820005349 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 998820005350 active site 998820005351 substrate binding site [chemical binding]; other site 998820005352 cosubstrate binding site; other site 998820005353 catalytic site [active] 998820005354 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 998820005355 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 998820005356 dimerization interface [polypeptide binding]; other site 998820005357 putative ATP binding site [chemical binding]; other site 998820005358 amidophosphoribosyltransferase; Provisional; Region: PRK07272 998820005359 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 998820005360 active site 998820005361 tetramer interface [polypeptide binding]; other site 998820005362 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 998820005363 active site 998820005364 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 998820005365 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 998820005366 dimerization interface [polypeptide binding]; other site 998820005367 ATP binding site [chemical binding]; other site 998820005368 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 998820005369 dimerization interface [polypeptide binding]; other site 998820005370 ATP binding site [chemical binding]; other site 998820005371 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 998820005372 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 998820005373 putative active site [active] 998820005374 catalytic triad [active] 998820005375 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 998820005376 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 998820005377 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 998820005378 ATP binding site [chemical binding]; other site 998820005379 active site 998820005380 substrate binding site [chemical binding]; other site 998820005381 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 998820005382 ATP-grasp domain; Region: ATP-grasp; pfam02222 998820005383 AIR carboxylase; Region: AIRC; pfam00731 998820005384 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 998820005385 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 998820005386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820005387 putative substrate translocation pore; other site 998820005388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820005389 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 998820005390 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 998820005391 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 998820005392 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 998820005393 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 998820005394 dimerization domain swap beta strand [polypeptide binding]; other site 998820005395 regulatory protein interface [polypeptide binding]; other site 998820005396 active site 998820005397 regulatory phosphorylation site [posttranslational modification]; other site 998820005398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 998820005399 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 998820005400 Walker A motif; other site 998820005401 ATP binding site [chemical binding]; other site 998820005402 Walker B motif; other site 998820005403 arginine finger; other site 998820005404 UvrB/uvrC motif; Region: UVR; pfam02151 998820005405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 998820005406 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 998820005407 Walker A motif; other site 998820005408 ATP binding site [chemical binding]; other site 998820005409 Walker B motif; other site 998820005410 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 998820005411 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 998820005412 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 998820005413 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 998820005414 G1 box; other site 998820005415 putative GEF interaction site [polypeptide binding]; other site 998820005416 GTP/Mg2+ binding site [chemical binding]; other site 998820005417 Switch I region; other site 998820005418 G2 box; other site 998820005419 G3 box; other site 998820005420 Switch II region; other site 998820005421 G4 box; other site 998820005422 G5 box; other site 998820005423 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 998820005424 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 998820005425 Domain of unknown function DUF21; Region: DUF21; pfam01595 998820005426 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 998820005427 Transporter associated domain; Region: CorC_HlyC; pfam03471 998820005428 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 998820005429 Domain of unknown function DUF20; Region: UPF0118; pfam01594 998820005430 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 998820005431 Coenzyme A binding pocket [chemical binding]; other site 998820005432 hypothetical protein; Provisional; Region: PRK13662 998820005433 RecX family; Region: RecX; cl00936 998820005434 Mga helix-turn-helix domain; Region: Mga; pfam05043 998820005435 TRAM domain; Region: TRAM; pfam01938 998820005436 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 998820005437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 998820005438 S-adenosylmethionine binding site [chemical binding]; other site 998820005439 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 998820005440 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 998820005441 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 998820005442 DNA-binding site [nucleotide binding]; DNA binding site 998820005443 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 998820005444 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 998820005445 beta-galactosidase; Region: BGL; TIGR03356 998820005446 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 998820005447 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 998820005448 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 998820005449 active site 998820005450 methionine cluster; other site 998820005451 phosphorylation site [posttranslational modification] 998820005452 metal binding site [ion binding]; metal-binding site 998820005453 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 998820005454 active site 998820005455 P-loop; other site 998820005456 phosphorylation site [posttranslational modification] 998820005457 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 998820005458 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 998820005459 PYR/PP interface [polypeptide binding]; other site 998820005460 dimer interface [polypeptide binding]; other site 998820005461 tetramer interface [polypeptide binding]; other site 998820005462 TPP binding site [chemical binding]; other site 998820005463 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 998820005464 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 998820005465 TPP-binding site [chemical binding]; other site 998820005466 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 998820005467 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 998820005468 dimer interface [polypeptide binding]; other site 998820005469 active site 998820005470 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 998820005471 homodimer interface [polypeptide binding]; other site 998820005472 catalytic residues [active] 998820005473 NAD binding site [chemical binding]; other site 998820005474 substrate binding pocket [chemical binding]; other site 998820005475 flexible flap; other site 998820005476 putative acyltransferase; Provisional; Region: PRK05790 998820005477 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 998820005478 dimer interface [polypeptide binding]; other site 998820005479 active site 998820005480 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 998820005481 Restriction endonuclease; Region: Mrr_cat; pfam04471 998820005482 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 998820005483 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 998820005484 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 998820005485 metal binding site [ion binding]; metal-binding site 998820005486 dimer interface [polypeptide binding]; other site 998820005487 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 998820005488 Predicted membrane protein [Function unknown]; Region: COG4684 998820005489 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 998820005490 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 998820005491 Coenzyme A binding pocket [chemical binding]; other site 998820005492 hypothetical protein; Provisional; Region: PRK04351 998820005493 SprT homologues; Region: SprT; cl01182 998820005494 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 998820005495 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820005496 Walker A/P-loop; other site 998820005497 ATP binding site [chemical binding]; other site 998820005498 Q-loop/lid; other site 998820005499 ABC transporter signature motif; other site 998820005500 Walker B; other site 998820005501 D-loop; other site 998820005502 H-loop/switch region; other site 998820005503 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 998820005504 TM-ABC transporter signature motif; other site 998820005505 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 998820005506 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 998820005507 zinc binding site [ion binding]; other site 998820005508 putative ligand binding site [chemical binding]; other site 998820005509 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 998820005510 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 998820005511 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 998820005512 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 998820005513 Soluble P-type ATPase [General function prediction only]; Region: COG4087 998820005514 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 998820005515 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 998820005516 Beta-lactamase; Region: Beta-lactamase; pfam00144 998820005517 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 998820005518 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 998820005519 homodimer interface [polypeptide binding]; other site 998820005520 NAD binding pocket [chemical binding]; other site 998820005521 ATP binding pocket [chemical binding]; other site 998820005522 Mg binding site [ion binding]; other site 998820005523 active-site loop [active] 998820005524 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 998820005525 Beta-lactamase; Region: Beta-lactamase; pfam00144 998820005526 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 998820005527 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 998820005528 active site 998820005529 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 998820005530 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 998820005531 DNA-binding site [nucleotide binding]; DNA binding site 998820005532 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 998820005533 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 998820005534 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 998820005535 active site 998820005536 dimer interface [polypeptide binding]; other site 998820005537 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 998820005538 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 998820005539 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 998820005540 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 998820005541 putative phosphoesterase; Region: acc_ester; TIGR03729 998820005542 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 998820005543 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 998820005544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820005545 putative substrate translocation pore; other site 998820005546 POT family; Region: PTR2; pfam00854 998820005547 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 998820005548 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 998820005549 Walker A/P-loop; other site 998820005550 ATP binding site [chemical binding]; other site 998820005551 Q-loop/lid; other site 998820005552 ABC transporter signature motif; other site 998820005553 Walker B; other site 998820005554 D-loop; other site 998820005555 H-loop/switch region; other site 998820005556 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 998820005557 FtsX-like permease family; Region: FtsX; pfam02687 998820005558 MFS/sugar transport protein; Region: MFS_2; pfam13347 998820005559 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 998820005560 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 998820005561 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 998820005562 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 998820005563 catalytic residues [active] 998820005564 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 998820005565 active site 998820005566 nucleotide-binding site [chemical binding]; other site 998820005567 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 998820005568 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 998820005569 G1 box; other site 998820005570 GTP/Mg2+ binding site [chemical binding]; other site 998820005571 Switch I region; other site 998820005572 G2 box; other site 998820005573 G3 box; other site 998820005574 Switch II region; other site 998820005575 G4 box; other site 998820005576 G5 box; other site 998820005577 Nucleoside recognition; Region: Gate; pfam07670 998820005578 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 998820005579 Nucleoside recognition; Region: Gate; pfam07670 998820005580 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 998820005581 FeoA domain; Region: FeoA; cl00838 998820005582 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 998820005583 catalytic triad [active] 998820005584 catalytic triad [active] 998820005585 oxyanion hole [active] 998820005586 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 998820005587 NADH(P)-binding; Region: NAD_binding_10; pfam13460 998820005588 NAD binding site [chemical binding]; other site 998820005589 substrate binding site [chemical binding]; other site 998820005590 putative active site [active] 998820005591 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 998820005592 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 998820005593 Domain of unknown function (DUF4323); Region: DUF4323; pfam14211 998820005594 seryl-tRNA synthetase; Provisional; Region: PRK05431 998820005595 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 998820005596 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 998820005597 dimer interface [polypeptide binding]; other site 998820005598 active site 998820005599 motif 1; other site 998820005600 motif 2; other site 998820005601 motif 3; other site 998820005602 Mga helix-turn-helix domain; Region: Mga; pfam05043 998820005603 Mga helix-turn-helix domain; Region: Mga; pfam05043 998820005604 lysine transporter; Provisional; Region: PRK10836 998820005605 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 998820005606 acetolactate synthase; Reviewed; Region: PRK08617 998820005607 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 998820005608 PYR/PP interface [polypeptide binding]; other site 998820005609 dimer interface [polypeptide binding]; other site 998820005610 TPP binding site [chemical binding]; other site 998820005611 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 998820005612 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 998820005613 TPP-binding site [chemical binding]; other site 998820005614 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 998820005615 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 998820005616 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 998820005617 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 998820005618 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 998820005619 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 998820005620 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 998820005621 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 998820005622 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 998820005623 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 998820005624 active site 998820005625 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 998820005626 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 998820005627 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 998820005628 Transcriptional regulators [Transcription]; Region: GntR; COG1802 998820005629 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 998820005630 DNA-binding site [nucleotide binding]; DNA binding site 998820005631 FCD domain; Region: FCD; pfam07729 998820005632 oxaloacetate decarboxylase; Provisional; Region: PRK12331 998820005633 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 998820005634 active site 998820005635 catalytic residues [active] 998820005636 metal binding site [ion binding]; metal-binding site 998820005637 homodimer binding site [polypeptide binding]; other site 998820005638 2'-(5''-triphosphoribosyl)-3'- dephospho-CoA:apo-citrate lyase; Reviewed; Region: citX; PRK01392 998820005639 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 998820005640 Coenzyme A transferase; Region: CoA_trans; cl17247 998820005641 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 998820005642 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 998820005643 citrate lyase subunit gamma; Provisional; Region: PRK13253 998820005644 [citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124 998820005645 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 998820005646 active site 998820005647 nucleotide binding site [chemical binding]; other site 998820005648 HIGH motif; other site 998820005649 KMSKS motif; other site 998820005650 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 998820005651 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 998820005652 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 998820005653 carboxyltransferase (CT) interaction site; other site 998820005654 biotinylation site [posttranslational modification]; other site 998820005655 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 998820005656 Citrate transporter; Region: CitMHS; pfam03600 998820005657 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 998820005658 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885 998820005659 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 998820005660 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 998820005661 Coenzyme A binding pocket [chemical binding]; other site 998820005662 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 998820005663 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 998820005664 Predicted transcriptional regulators [Transcription]; Region: COG1695 998820005665 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 998820005666 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 998820005667 dimer interface [polypeptide binding]; other site 998820005668 FMN binding site [chemical binding]; other site 998820005669 NADPH bind site [chemical binding]; other site 998820005670 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 998820005671 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 998820005672 Walker A/P-loop; other site 998820005673 ATP binding site [chemical binding]; other site 998820005674 Q-loop/lid; other site 998820005675 ABC transporter signature motif; other site 998820005676 Walker B; other site 998820005677 D-loop; other site 998820005678 H-loop/switch region; other site 998820005679 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 998820005680 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 998820005681 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 998820005682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820005683 Major Facilitator Superfamily; Region: MFS_1; pfam07690 998820005684 putative substrate translocation pore; other site 998820005685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820005686 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 998820005687 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 998820005688 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 998820005689 non-specific DNA binding site [nucleotide binding]; other site 998820005690 salt bridge; other site 998820005691 sequence-specific DNA binding site [nucleotide binding]; other site 998820005692 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 998820005693 Predicted transcriptional regulators [Transcription]; Region: COG1725 998820005694 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 998820005695 DNA-binding site [nucleotide binding]; DNA binding site 998820005696 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 998820005697 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820005698 Walker A/P-loop; other site 998820005699 ATP binding site [chemical binding]; other site 998820005700 Q-loop/lid; other site 998820005701 ABC transporter signature motif; other site 998820005702 Walker B; other site 998820005703 D-loop; other site 998820005704 H-loop/switch region; other site 998820005705 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 998820005706 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 998820005707 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 998820005708 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 998820005709 Walker A/P-loop; other site 998820005710 ATP binding site [chemical binding]; other site 998820005711 Q-loop/lid; other site 998820005712 ABC transporter signature motif; other site 998820005713 Walker B; other site 998820005714 D-loop; other site 998820005715 H-loop/switch region; other site 998820005716 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 998820005717 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 998820005718 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 998820005719 Walker A/P-loop; other site 998820005720 ATP binding site [chemical binding]; other site 998820005721 Q-loop/lid; other site 998820005722 ABC transporter signature motif; other site 998820005723 Walker B; other site 998820005724 D-loop; other site 998820005725 H-loop/switch region; other site 998820005726 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 998820005727 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 998820005728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820005729 dimer interface [polypeptide binding]; other site 998820005730 conserved gate region; other site 998820005731 putative PBP binding loops; other site 998820005732 ABC-ATPase subunit interface; other site 998820005733 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 998820005734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820005735 dimer interface [polypeptide binding]; other site 998820005736 conserved gate region; other site 998820005737 putative PBP binding loops; other site 998820005738 ABC-ATPase subunit interface; other site 998820005739 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 998820005740 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 998820005741 peptide binding site [polypeptide binding]; other site 998820005742 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 998820005743 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 998820005744 potential catalytic triad [active] 998820005745 conserved cys residue [active] 998820005746 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 998820005747 putative DNA binding site [nucleotide binding]; other site 998820005748 putative Zn2+ binding site [ion binding]; other site 998820005749 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 998820005750 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 998820005751 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820005752 Walker A/P-loop; other site 998820005753 ATP binding site [chemical binding]; other site 998820005754 Q-loop/lid; other site 998820005755 ABC transporter signature motif; other site 998820005756 Walker B; other site 998820005757 D-loop; other site 998820005758 H-loop/switch region; other site 998820005759 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 998820005760 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 998820005761 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 998820005762 Walker A/P-loop; other site 998820005763 ATP binding site [chemical binding]; other site 998820005764 Q-loop/lid; other site 998820005765 ABC transporter signature motif; other site 998820005766 Walker B; other site 998820005767 D-loop; other site 998820005768 H-loop/switch region; other site 998820005769 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 998820005770 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 998820005771 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 998820005772 active site 998820005773 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 998820005774 Helix-turn-helix domain; Region: HTH_38; pfam13936 998820005775 Integrase core domain; Region: rve; pfam00665 998820005776 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 998820005777 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 998820005778 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 998820005779 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 998820005780 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 998820005781 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 998820005782 non-specific DNA binding site [nucleotide binding]; other site 998820005783 salt bridge; other site 998820005784 sequence-specific DNA binding site [nucleotide binding]; other site 998820005785 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 998820005786 Homeodomain-like domain; Region: HTH_23; cl17451 998820005787 Transposase; Region: DDE_Tnp_ISL3; pfam01610 998820005788 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 998820005789 Transposase; Region: DDE_Tnp_ISL3; pfam01610 998820005790 Integrase core domain; Region: rve; pfam00665 998820005791 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 998820005792 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 998820005793 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 998820005794 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 998820005795 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 998820005796 Helix-turn-helix domain; Region: HTH_38; pfam13936 998820005797 Integrase core domain; Region: rve; pfam00665 998820005798 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 998820005799 Transposase; Region: HTH_Tnp_1; pfam01527 998820005800 HTH-like domain; Region: HTH_21; pfam13276 998820005801 Integrase core domain; Region: rve; pfam00665 998820005802 Integrase core domain; Region: rve_3; pfam13683 998820005803 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 998820005804 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 998820005805 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 998820005806 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 998820005807 Cl binding site [ion binding]; other site 998820005808 oligomer interface [polypeptide binding]; other site 998820005809 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 998820005810 Helix-turn-helix domain; Region: HTH_38; pfam13936 998820005811 Integrase core domain; Region: rve; pfam00665 998820005812 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 998820005813 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 998820005814 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_2; cd08769 998820005815 SxDxEG motif; other site 998820005816 putative active site [active] 998820005817 putative metal binding site [ion binding]; other site 998820005818 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 998820005819 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 998820005820 oligomer interface [polypeptide binding]; other site 998820005821 active site 998820005822 metal binding site [ion binding]; metal-binding site 998820005823 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 998820005824 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 998820005825 peptide binding site [polypeptide binding]; other site 998820005826 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 998820005827 Integrase core domain; Region: rve; pfam00665 998820005828 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 998820005829 Helix-turn-helix domain; Region: HTH_16; pfam12645 998820005830 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 998820005831 PAZ domain, named PAZ after the proteins Piwi Argonaut and Zwille. PAZ is found in two families of proteins that are essential components of RNA-mediated gene-silencing pathways, including RNA interference, the piwi and Dicer families. PAZ functions as a...; Region: PAZ; cl00301 998820005832 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 998820005833 nucleic acid-binding interface [nucleotide binding]; other site 998820005834 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 998820005835 Int/Topo IB signature motif; other site 998820005836 GMP synthase; Reviewed; Region: guaA; PRK00074 998820005837 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 998820005838 AMP/PPi binding site [chemical binding]; other site 998820005839 candidate oxyanion hole; other site 998820005840 catalytic triad [active] 998820005841 potential glutamine specificity residues [chemical binding]; other site 998820005842 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 998820005843 ATP Binding subdomain [chemical binding]; other site 998820005844 Dimerization subdomain; other site 998820005845 pantothenate kinase; Provisional; Region: PRK05439 998820005846 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 998820005847 ATP-binding site [chemical binding]; other site 998820005848 CoA-binding site [chemical binding]; other site 998820005849 Mg2+-binding site [ion binding]; other site 998820005850 Peptidase family C69; Region: Peptidase_C69; pfam03577 998820005851 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 998820005852 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 998820005853 Part of AAA domain; Region: AAA_19; pfam13245 998820005854 Family description; Region: UvrD_C_2; pfam13538 998820005855 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 998820005856 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 998820005857 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 998820005858 TrkA-C domain; Region: TrkA_C; pfam02080 998820005859 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 998820005860 manganese transport protein MntH; Reviewed; Region: PRK00701 998820005861 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 998820005862 Ferrochelatase; Region: Ferrochelatase; pfam00762 998820005863 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 998820005864 C-terminal domain interface [polypeptide binding]; other site 998820005865 active site 998820005866 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 998820005867 active site 998820005868 N-terminal domain interface [polypeptide binding]; other site 998820005869 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 998820005870 catalytic core [active] 998820005871 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 998820005872 FtsX-like permease family; Region: FtsX; pfam02687 998820005873 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 998820005874 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 998820005875 Walker A/P-loop; other site 998820005876 ATP binding site [chemical binding]; other site 998820005877 Q-loop/lid; other site 998820005878 ABC transporter signature motif; other site 998820005879 Walker B; other site 998820005880 D-loop; other site 998820005881 H-loop/switch region; other site 998820005882 Amino acid permease; Region: AA_permease_2; pfam13520 998820005883 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 998820005884 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 998820005885 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 998820005886 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 998820005887 HflX GTPase family; Region: HflX; cd01878 998820005888 G1 box; other site 998820005889 GTP/Mg2+ binding site [chemical binding]; other site 998820005890 Switch I region; other site 998820005891 G2 box; other site 998820005892 G3 box; other site 998820005893 Switch II region; other site 998820005894 G4 box; other site 998820005895 G5 box; other site 998820005896 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 998820005897 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 998820005898 NodB motif; other site 998820005899 active site 998820005900 catalytic site [active] 998820005901 Zn binding site [ion binding]; other site 998820005902 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 998820005903 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 998820005904 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 998820005905 putative active site [active] 998820005906 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 998820005907 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 998820005908 NADP binding site [chemical binding]; other site 998820005909 active site 998820005910 putative substrate binding site [chemical binding]; other site 998820005911 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 998820005912 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 998820005913 NAD binding site [chemical binding]; other site 998820005914 substrate binding site [chemical binding]; other site 998820005915 homodimer interface [polypeptide binding]; other site 998820005916 active site 998820005917 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 998820005918 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 998820005919 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 998820005920 substrate binding site; other site 998820005921 tetramer interface; other site 998820005922 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 998820005923 Bacterial sugar transferase; Region: Bac_transf; pfam02397 998820005924 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 998820005925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 998820005926 NAD(P) binding site [chemical binding]; other site 998820005927 active site 998820005928 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 998820005929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820005930 dimer interface [polypeptide binding]; other site 998820005931 conserved gate region; other site 998820005932 putative PBP binding loops; other site 998820005933 ABC-ATPase subunit interface; other site 998820005934 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 998820005935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820005936 dimer interface [polypeptide binding]; other site 998820005937 conserved gate region; other site 998820005938 putative PBP binding loops; other site 998820005939 ABC-ATPase subunit interface; other site 998820005940 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 998820005941 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 998820005942 substrate binding pocket [chemical binding]; other site 998820005943 membrane-bound complex binding site; other site 998820005944 hinge residues; other site 998820005945 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 998820005946 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 998820005947 Walker A/P-loop; other site 998820005948 ATP binding site [chemical binding]; other site 998820005949 Q-loop/lid; other site 998820005950 ABC transporter signature motif; other site 998820005951 Walker B; other site 998820005952 D-loop; other site 998820005953 H-loop/switch region; other site 998820005954 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 998820005955 metal binding site 2 [ion binding]; metal-binding site 998820005956 putative DNA binding helix; other site 998820005957 metal binding site 1 [ion binding]; metal-binding site 998820005958 dimer interface [polypeptide binding]; other site 998820005959 structural Zn2+ binding site [ion binding]; other site 998820005960 Guanylate kinase; Region: Guanylate_kin; pfam00625 998820005961 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 998820005962 active site 998820005963 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 998820005964 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 998820005965 Coenzyme A binding pocket [chemical binding]; other site 998820005966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 998820005967 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 998820005968 NlpC/P60 family; Region: NLPC_P60; pfam00877 998820005969 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 998820005970 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 998820005971 active site 998820005972 HIGH motif; other site 998820005973 dimer interface [polypeptide binding]; other site 998820005974 KMSKS motif; other site 998820005975 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 998820005976 RNA binding surface [nucleotide binding]; other site 998820005977 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 998820005978 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 998820005979 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 998820005980 dimerization interface [polypeptide binding]; other site 998820005981 putative DNA binding site [nucleotide binding]; other site 998820005982 putative Zn2+ binding site [ion binding]; other site 998820005983 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 998820005984 ApbE family; Region: ApbE; pfam02424 998820005985 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 998820005986 active site 998820005987 homodimer interface [polypeptide binding]; other site 998820005988 catalytic site [active] 998820005989 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 998820005990 homodimer interface [polypeptide binding]; other site 998820005991 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 998820005992 active site pocket [active] 998820005993 glycogen synthase; Provisional; Region: glgA; PRK00654 998820005994 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 998820005995 ADP-binding pocket [chemical binding]; other site 998820005996 homodimer interface [polypeptide binding]; other site 998820005997 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 998820005998 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 998820005999 active site 998820006000 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 998820006001 dimer interface [polypeptide binding]; other site 998820006002 N-terminal domain interface [polypeptide binding]; other site 998820006003 sulfate 1 binding site; other site 998820006004 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 998820006005 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 998820006006 ligand binding site; other site 998820006007 oligomer interface; other site 998820006008 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 998820006009 dimer interface [polypeptide binding]; other site 998820006010 N-terminal domain interface [polypeptide binding]; other site 998820006011 sulfate 1 binding site; other site 998820006012 glycogen branching enzyme; Provisional; Region: PRK12313 998820006013 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 998820006014 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 998820006015 active site 998820006016 catalytic site [active] 998820006017 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 998820006018 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 998820006019 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 998820006020 homodimer interface [polypeptide binding]; other site 998820006021 substrate-cofactor binding pocket; other site 998820006022 catalytic residue [active] 998820006023 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 998820006024 Uncharacterized conserved protein [Function unknown]; Region: COG1284 998820006025 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 998820006026 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 998820006027 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 998820006028 ArsC family; Region: ArsC; pfam03960 998820006029 putative catalytic residues [active] 998820006030 thiol/disulfide switch; other site 998820006031 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 998820006032 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 998820006033 Walker A motif; other site 998820006034 ATP binding site [chemical binding]; other site 998820006035 Walker B motif; other site 998820006036 arginine finger; other site 998820006037 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 998820006038 Walker A motif; other site 998820006039 ATP binding site [chemical binding]; other site 998820006040 Walker B motif; other site 998820006041 arginine finger; other site 998820006042 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 998820006043 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 998820006044 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 998820006045 Transposase domain (DUF772); Region: DUF772; pfam05598 998820006046 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 998820006047 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 998820006048 Homeodomain-like domain; Region: HTH_23; pfam13384 998820006049 Transposase; Region: DDE_Tnp_ISL3; pfam01610 998820006050 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 998820006051 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 998820006052 NADP binding site [chemical binding]; other site 998820006053 active site 998820006054 putative substrate binding site [chemical binding]; other site 998820006055 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 998820006056 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 998820006057 NAD binding site [chemical binding]; other site 998820006058 substrate binding site [chemical binding]; other site 998820006059 homodimer interface [polypeptide binding]; other site 998820006060 active site 998820006061 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 998820006062 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 998820006063 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 998820006064 substrate binding site; other site 998820006065 tetramer interface; other site 998820006066 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 998820006067 Bacterial sugar transferase; Region: Bac_transf; pfam02397 998820006068 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 998820006069 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 998820006070 active site 998820006071 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 998820006072 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 998820006073 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 998820006074 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 998820006075 trimer interface [polypeptide binding]; other site 998820006076 active site 998820006077 substrate binding site [chemical binding]; other site 998820006078 CoA binding site [chemical binding]; other site 998820006079 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 998820006080 active site 998820006081 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 998820006082 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 998820006083 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 998820006084 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 998820006085 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 998820006086 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 998820006087 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 998820006088 Chain length determinant protein; Region: Wzz; cl15801 998820006089 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 998820006090 catalytic triad [active] 998820006091 catalytic triad [active] 998820006092 oxyanion hole [active] 998820006093 QueT transporter; Region: QueT; pfam06177 998820006094 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 998820006095 classical (c) SDRs; Region: SDR_c; cd05233 998820006096 NAD(P) binding site [chemical binding]; other site 998820006097 active site 998820006098 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 998820006099 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 998820006100 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 998820006101 non-specific DNA binding site [nucleotide binding]; other site 998820006102 salt bridge; other site 998820006103 sequence-specific DNA binding site [nucleotide binding]; other site 998820006104 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 998820006105 catalytic core [active] 998820006106 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 998820006107 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 998820006108 Walker A/P-loop; other site 998820006109 ATP binding site [chemical binding]; other site 998820006110 Q-loop/lid; other site 998820006111 ABC transporter signature motif; other site 998820006112 Walker B; other site 998820006113 D-loop; other site 998820006114 H-loop/switch region; other site 998820006115 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 998820006116 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 998820006117 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 998820006118 Walker A/P-loop; other site 998820006119 ATP binding site [chemical binding]; other site 998820006120 Q-loop/lid; other site 998820006121 ABC transporter signature motif; other site 998820006122 Walker B; other site 998820006123 D-loop; other site 998820006124 H-loop/switch region; other site 998820006125 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 998820006126 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 998820006127 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 998820006128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820006129 dimer interface [polypeptide binding]; other site 998820006130 conserved gate region; other site 998820006131 putative PBP binding loops; other site 998820006132 ABC-ATPase subunit interface; other site 998820006133 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 998820006134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820006135 dimer interface [polypeptide binding]; other site 998820006136 conserved gate region; other site 998820006137 putative PBP binding loops; other site 998820006138 ABC-ATPase subunit interface; other site 998820006139 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 998820006140 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 998820006141 peptide binding site [polypeptide binding]; other site 998820006142 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 998820006143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820006144 putative substrate translocation pore; other site 998820006145 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 998820006146 Helix-turn-helix domain; Region: HTH_38; pfam13936 998820006147 Integrase core domain; Region: rve; pfam00665 998820006148 elongation factor P; Validated; Region: PRK00529 998820006149 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 998820006150 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 998820006151 RNA binding site [nucleotide binding]; other site 998820006152 Elongation factor P, C-terminal; Region: Elong-fact-P_C; pfam09285 998820006153 RNA binding site [nucleotide binding]; other site 998820006154 Uncharacterized conserved protein [Function unknown]; Region: COG1556 998820006155 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 998820006156 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 998820006157 4Fe-4S binding domain; Region: Fer4; pfam00037 998820006158 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 998820006159 Cysteine-rich domain; Region: CCG; pfam02754 998820006160 Cysteine-rich domain; Region: CCG; pfam02754 998820006161 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 998820006162 active site 998820006163 methionine cluster; other site 998820006164 phosphorylation site [posttranslational modification] 998820006165 metal binding site [ion binding]; metal-binding site 998820006166 Uncharacterized conserved protein [Function unknown]; Region: COG3589 998820006167 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 998820006168 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 998820006169 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 998820006170 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 998820006171 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 998820006172 Melibiase; Region: Melibiase; pfam02065 998820006173 hypothetical protein; Validated; Region: PRK02101 998820006174 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 998820006175 DNA binding residues [nucleotide binding] 998820006176 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 998820006177 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 998820006178 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 998820006179 AAA domain; Region: AAA_30; pfam13604 998820006180 Family description; Region: UvrD_C_2; pfam13538 998820006181 WxL domain surface cell wall-binding; Region: WxL; pfam13731 998820006182 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 998820006183 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 998820006184 substrate binding site [chemical binding]; other site 998820006185 ATP binding site [chemical binding]; other site 998820006186 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 998820006187 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 998820006188 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 998820006189 Uncharacterized conserved protein [Function unknown]; Region: COG3535 998820006190 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 998820006191 Na binding site [ion binding]; other site 998820006192 Protein of unknown function DUF262; Region: DUF262; pfam03235 998820006193 Uncharacterized conserved protein [Function unknown]; Region: COG1479 998820006194 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 998820006195 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 998820006196 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 998820006197 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 998820006198 Int/Topo IB signature motif; other site 998820006199 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 998820006200 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 998820006201 Methyltransferase domain; Region: Methyltransf_26; pfam13659 998820006202 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 998820006203 HsdM N-terminal domain; Region: HsdM_N; pfam12161 998820006204 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 998820006205 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 998820006206 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 998820006207 ATP binding site [chemical binding]; other site 998820006208 putative Mg++ binding site [ion binding]; other site 998820006209 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 998820006210 Protein of unknown function (DUF998); Region: DUF998; pfam06197 998820006211 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 998820006212 HPr interaction site; other site 998820006213 glycerol kinase (GK) interaction site [polypeptide binding]; other site 998820006214 active site 998820006215 phosphorylation site [posttranslational modification] 998820006216 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 998820006217 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 998820006218 active site turn [active] 998820006219 phosphorylation site [posttranslational modification] 998820006220 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 998820006221 Transcriptional regulators [Transcription]; Region: PurR; COG1609 998820006222 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 998820006223 DNA binding site [nucleotide binding] 998820006224 domain linker motif; other site 998820006225 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 998820006226 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 998820006227 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 998820006228 substrate binding [chemical binding]; other site 998820006229 active site 998820006230 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 998820006231 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 998820006232 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 998820006233 NADP binding site [chemical binding]; other site 998820006234 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 998820006235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 998820006236 S-adenosylmethionine binding site [chemical binding]; other site 998820006237 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 998820006238 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 998820006239 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 998820006240 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 998820006241 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 998820006242 ATP-grasp domain; Region: ATP-grasp_4; cl17255 998820006243 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 998820006244 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 998820006245 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 998820006246 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 998820006247 carboxyltransferase (CT) interaction site; other site 998820006248 biotinylation site [posttranslational modification]; other site 998820006249 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 998820006250 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 998820006251 dimer interface [polypeptide binding]; other site 998820006252 active site 998820006253 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 998820006254 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 998820006255 NAD(P) binding site [chemical binding]; other site 998820006256 homotetramer interface [polypeptide binding]; other site 998820006257 homodimer interface [polypeptide binding]; other site 998820006258 active site 998820006259 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 998820006260 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 998820006261 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 998820006262 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 998820006263 FMN binding site [chemical binding]; other site 998820006264 substrate binding site [chemical binding]; other site 998820006265 putative catalytic residue [active] 998820006266 acyl carrier protein; Provisional; Region: acpP; PRK00982 998820006267 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 998820006268 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 998820006269 dimer interface [polypeptide binding]; other site 998820006270 active site 998820006271 CoA binding pocket [chemical binding]; other site 998820006272 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 998820006273 MarR family; Region: MarR_2; pfam12802 998820006274 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 998820006275 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 998820006276 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 998820006277 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 998820006278 dimer interface [polypeptide binding]; other site 998820006279 active site 998820006280 metal binding site [ion binding]; metal-binding site 998820006281 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 998820006282 Helix-turn-helix domain; Region: HTH_38; pfam13936 998820006283 Integrase core domain; Region: rve; pfam00665 998820006284 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078 998820006285 Transcriptional regulators [Transcription]; Region: MarR; COG1846 998820006286 MarR family; Region: MarR_2; pfam12802 998820006287 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 998820006288 S-formylglutathione hydrolase; Region: PLN02442 998820006289 Putative esterase; Region: Esterase; pfam00756 998820006290 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 998820006291 Double zinc ribbon; Region: DZR; pfam12773 998820006292 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 998820006293 putative DNA binding site [nucleotide binding]; other site 998820006294 putative Zn2+ binding site [ion binding]; other site 998820006295 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 998820006296 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 998820006297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820006298 Walker A/P-loop; other site 998820006299 ATP binding site [chemical binding]; other site 998820006300 Q-loop/lid; other site 998820006301 ABC transporter signature motif; other site 998820006302 Walker B; other site 998820006303 D-loop; other site 998820006304 H-loop/switch region; other site 998820006305 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 998820006306 nudix motif; other site 998820006307 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 998820006308 catalytic core [active] 998820006309 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 998820006310 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 998820006311 Double zinc ribbon; Region: DZR; pfam12773 998820006312 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 998820006313 Beta-lactamase; Region: Beta-lactamase; pfam00144 998820006314 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 998820006315 Domain of unknown function DUF20; Region: UPF0118; pfam01594 998820006316 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 998820006317 active site 998820006318 catalytic site [active] 998820006319 Predicted membrane protein [Function unknown]; Region: COG2246 998820006320 GtrA-like protein; Region: GtrA; pfam04138 998820006321 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 998820006322 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 998820006323 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 998820006324 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 998820006325 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 998820006326 PYR/PP interface [polypeptide binding]; other site 998820006327 dimer interface [polypeptide binding]; other site 998820006328 TPP binding site [chemical binding]; other site 998820006329 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 998820006330 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 998820006331 TPP-binding site [chemical binding]; other site 998820006332 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 998820006333 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 998820006334 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 998820006335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820006336 dimer interface [polypeptide binding]; other site 998820006337 conserved gate region; other site 998820006338 putative PBP binding loops; other site 998820006339 ABC-ATPase subunit interface; other site 998820006340 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 998820006341 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 998820006342 Walker A/P-loop; other site 998820006343 ATP binding site [chemical binding]; other site 998820006344 Q-loop/lid; other site 998820006345 ABC transporter signature motif; other site 998820006346 Walker B; other site 998820006347 D-loop; other site 998820006348 H-loop/switch region; other site 998820006349 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 998820006350 DNA-binding protein, stimulates sugar fermentation [General function prediction only]; Region: SfsA; COG1489 998820006351 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 998820006352 Ligand Binding Site [chemical binding]; other site 998820006353 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 998820006354 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 998820006355 homoserine kinase; Provisional; Region: PRK01212 998820006356 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 998820006357 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 998820006358 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 998820006359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 998820006360 catalytic residue [active] 998820006361 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 998820006362 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 998820006363 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 998820006364 aspartate kinase; Reviewed; Region: PRK09034 998820006365 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 998820006366 nucleotide binding site [chemical binding]; other site 998820006367 substrate binding site [chemical binding]; other site 998820006368 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 998820006369 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 998820006370 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 998820006371 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 998820006372 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 998820006373 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 998820006374 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 998820006375 homodimer interface [polypeptide binding]; other site 998820006376 ligand binding site [chemical binding]; other site 998820006377 NAD binding site [chemical binding]; other site 998820006378 catalytic site [active] 998820006379 aromatic amino acid aminotransferase; Validated; Region: PRK07309 998820006380 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 998820006381 pyridoxal 5'-phosphate binding site [chemical binding]; other site 998820006382 homodimer interface [polypeptide binding]; other site 998820006383 catalytic residue [active] 998820006384 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 998820006385 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 998820006386 nucleotide binding site/active site [active] 998820006387 HIT family signature motif; other site 998820006388 catalytic residue [active] 998820006389 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 998820006390 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 998820006391 active site 998820006392 dimer interface [polypeptide binding]; other site 998820006393 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 998820006394 Ligand Binding Site [chemical binding]; other site 998820006395 Molecular Tunnel; other site 998820006396 Predicted integral membrane protein [Function unknown]; Region: COG0392 998820006397 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 998820006398 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 998820006399 active site 998820006400 metal binding site [ion binding]; metal-binding site 998820006401 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 998820006402 UbiA prenyltransferase family; Region: UbiA; pfam01040 998820006403 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 998820006404 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 998820006405 substrate binding pocket [chemical binding]; other site 998820006406 chain length determination region; other site 998820006407 substrate-Mg2+ binding site; other site 998820006408 catalytic residues [active] 998820006409 aspartate-rich region 1; other site 998820006410 active site lid residues [active] 998820006411 aspartate-rich region 2; other site 998820006412 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 998820006413 propionate/acetate kinase; Provisional; Region: PRK12379 998820006414 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 998820006415 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820006416 Walker A/P-loop; other site 998820006417 ATP binding site [chemical binding]; other site 998820006418 Q-loop/lid; other site 998820006419 ABC transporter signature motif; other site 998820006420 Walker B; other site 998820006421 D-loop; other site 998820006422 H-loop/switch region; other site 998820006423 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 998820006424 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 998820006425 Predicted transcriptional regulators [Transcription]; Region: COG1725 998820006426 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 998820006427 DNA-binding site [nucleotide binding]; DNA binding site 998820006428 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 998820006429 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 998820006430 Walker A/P-loop; other site 998820006431 ATP binding site [chemical binding]; other site 998820006432 Q-loop/lid; other site 998820006433 ABC transporter signature motif; other site 998820006434 Walker B; other site 998820006435 D-loop; other site 998820006436 H-loop/switch region; other site 998820006437 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 998820006438 glucose-1-dehydrogenase; Provisional; Region: PRK08936 998820006439 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 998820006440 NAD binding site [chemical binding]; other site 998820006441 homodimer interface [polypeptide binding]; other site 998820006442 active site 998820006443 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 998820006444 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 998820006445 hexamer interface [polypeptide binding]; other site 998820006446 ligand binding site [chemical binding]; other site 998820006447 putative active site [active] 998820006448 NAD(P) binding site [chemical binding]; other site 998820006449 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 998820006450 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 998820006451 tetramer interface [polypeptide binding]; other site 998820006452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 998820006453 catalytic residue [active] 998820006454 potential frameshift: common BLAST hit: gi|81427933|ref|YP_394932.1| oligopeptide transporter 998820006455 OPT oligopeptide transporter protein; Region: OPT; cl14607 998820006456 OPT oligopeptide transporter protein; Region: OPT; cl14607 998820006457 OPT oligopeptide transporter protein; Region: OPT; cl14607 998820006458 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 998820006459 Peptidase family C69; Region: Peptidase_C69; pfam03577 998820006460 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 998820006461 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 998820006462 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 998820006463 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 998820006464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820006465 Major Facilitator Superfamily; Region: MFS_1; pfam07690 998820006466 putative substrate translocation pore; other site 998820006467 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 998820006468 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 998820006469 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 998820006470 beta-galactosidase; Region: BGL; TIGR03356 998820006471 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 998820006472 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 998820006473 active site turn [active] 998820006474 phosphorylation site [posttranslational modification] 998820006475 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 998820006476 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 998820006477 HPr interaction site; other site 998820006478 glycerol kinase (GK) interaction site [polypeptide binding]; other site 998820006479 active site 998820006480 phosphorylation site [posttranslational modification] 998820006481 transcriptional antiterminator BglG; Provisional; Region: PRK09772 998820006482 CAT RNA binding domain; Region: CAT_RBD; smart01061 998820006483 PRD domain; Region: PRD; pfam00874 998820006484 PRD domain; Region: PRD; pfam00874 998820006485 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 998820006486 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 998820006487 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 998820006488 Walker A/P-loop; other site 998820006489 ATP binding site [chemical binding]; other site 998820006490 Q-loop/lid; other site 998820006491 ABC transporter signature motif; other site 998820006492 Walker B; other site 998820006493 D-loop; other site 998820006494 H-loop/switch region; other site 998820006495 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 998820006496 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 998820006497 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820006498 Walker A/P-loop; other site 998820006499 ATP binding site [chemical binding]; other site 998820006500 Q-loop/lid; other site 998820006501 ABC transporter signature motif; other site 998820006502 Walker B; other site 998820006503 D-loop; other site 998820006504 H-loop/switch region; other site 998820006505 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 998820006506 trimer interface [polypeptide binding]; other site 998820006507 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 998820006508 Transposase; Region: HTH_Tnp_1; pfam01527 998820006509 putative transposase OrfB; Reviewed; Region: PHA02517 998820006510 HTH-like domain; Region: HTH_21; pfam13276 998820006511 Integrase core domain; Region: rve; pfam00665 998820006512 Integrase core domain; Region: rve_3; pfam13683 998820006513 CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd12218 998820006514 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 998820006515 tetramer interface [polypeptide binding]; other site 998820006516 putative DNA binding site [nucleotide binding]; other site 998820006517 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 998820006518 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 998820006519 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 998820006520 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 998820006521 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 998820006522 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 998820006523 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 998820006524 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 998820006525 Walker A/P-loop; other site 998820006526 ATP binding site [chemical binding]; other site 998820006527 Q-loop/lid; other site 998820006528 ABC transporter signature motif; other site 998820006529 Walker B; other site 998820006530 D-loop; other site 998820006531 H-loop/switch region; other site 998820006532 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 998820006533 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 998820006534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820006535 Walker A/P-loop; other site 998820006536 ATP binding site [chemical binding]; other site 998820006537 Q-loop/lid; other site 998820006538 ABC transporter signature motif; other site 998820006539 Walker B; other site 998820006540 D-loop; other site 998820006541 H-loop/switch region; other site 998820006542 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 998820006543 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 998820006544 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 998820006545 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 998820006546 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 998820006547 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 998820006548 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 998820006549 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 998820006550 adenosine deaminase; Provisional; Region: PRK09358 998820006551 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 998820006552 active site 998820006553 Protein of unknown function (DUF460); Region: DUF460; pfam04312 998820006554 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 998820006555 EamA-like transporter family; Region: EamA; pfam00892 998820006556 EamA-like transporter family; Region: EamA; pfam00892 998820006557 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 998820006558 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 998820006559 Ligand Binding Site [chemical binding]; other site 998820006560 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 998820006561 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 998820006562 non-specific DNA binding site [nucleotide binding]; other site 998820006563 salt bridge; other site 998820006564 sequence-specific DNA binding site [nucleotide binding]; other site 998820006565 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 998820006566 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 998820006567 epoxyqueuosine reductase; Region: TIGR00276 998820006568 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 998820006569 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 998820006570 protein binding surface [polypeptide binding]; other site 998820006571 HEAT repeats; Region: HEAT_2; pfam13646 998820006572 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 998820006573 Helix-turn-helix domain; Region: HTH_38; pfam13936 998820006574 Integrase core domain; Region: rve; pfam00665 998820006575 BioY family; Region: BioY; pfam02632 998820006576 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 998820006577 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 998820006578 DNA binding residues [nucleotide binding] 998820006579 putative dimer interface [polypeptide binding]; other site 998820006580 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 998820006581 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 998820006582 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 998820006583 catalytic Zn binding site [ion binding]; other site 998820006584 NAD(P) binding site [chemical binding]; other site 998820006585 structural Zn binding site [ion binding]; other site 998820006586 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 998820006587 NADH(P)-binding; Region: NAD_binding_10; pfam13460 998820006588 putative NAD(P) binding site [chemical binding]; other site 998820006589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 998820006590 S-adenosylmethionine binding site [chemical binding]; other site 998820006591 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 998820006592 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 998820006593 catalytic triad [active] 998820006594 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 998820006595 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 998820006596 Domain of unknown function DUF21; Region: DUF21; pfam01595 998820006597 FOG: CBS domain [General function prediction only]; Region: COG0517 998820006598 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 998820006599 Transporter associated domain; Region: CorC_HlyC; smart01091 998820006600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820006601 Major Facilitator Superfamily; Region: MFS_1; pfam07690 998820006602 Maf-like protein; Region: Maf; pfam02545 998820006603 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 998820006604 active site 998820006605 dimer interface [polypeptide binding]; other site 998820006606 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 998820006607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 998820006608 ATP binding site [chemical binding]; other site 998820006609 Mg2+ binding site [ion binding]; other site 998820006610 G-X-G motif; other site 998820006611 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 998820006612 ATP binding site [chemical binding]; other site 998820006613 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 998820006614 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 998820006615 MutS domain I; Region: MutS_I; pfam01624 998820006616 MutS domain II; Region: MutS_II; pfam05188 998820006617 MutS domain III; Region: MutS_III; pfam05192 998820006618 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 998820006619 Walker A/P-loop; other site 998820006620 ATP binding site [chemical binding]; other site 998820006621 Q-loop/lid; other site 998820006622 ABC transporter signature motif; other site 998820006623 Walker B; other site 998820006624 D-loop; other site 998820006625 H-loop/switch region; other site 998820006626 Amino acid permease; Region: AA_permease_2; pfam13520 998820006627 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 998820006628 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 998820006629 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 998820006630 ring oligomerisation interface [polypeptide binding]; other site 998820006631 ATP/Mg binding site [chemical binding]; other site 998820006632 stacking interactions; other site 998820006633 hinge regions; other site 998820006634 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 998820006635 oligomerisation interface [polypeptide binding]; other site 998820006636 mobile loop; other site 998820006637 roof hairpin; other site 998820006638 CAAX protease self-immunity; Region: Abi; pfam02517 998820006639 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 998820006640 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 998820006641 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 998820006642 Walker A/P-loop; other site 998820006643 ATP binding site [chemical binding]; other site 998820006644 Q-loop/lid; other site 998820006645 ABC transporter signature motif; other site 998820006646 Walker B; other site 998820006647 D-loop; other site 998820006648 H-loop/switch region; other site 998820006649 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 998820006650 DNA-binding site [nucleotide binding]; DNA binding site 998820006651 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 998820006652 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 998820006653 CoA binding domain; Region: CoA_binding; pfam02629 998820006654 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 998820006655 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820006656 Walker A/P-loop; other site 998820006657 ATP binding site [chemical binding]; other site 998820006658 Q-loop/lid; other site 998820006659 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 998820006660 ABC transporter signature motif; other site 998820006661 Walker B; other site 998820006662 D-loop; other site 998820006663 ABC transporter; Region: ABC_tran_2; pfam12848 998820006664 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 998820006665 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 998820006666 active site 998820006667 P-loop; other site 998820006668 phosphorylation site [posttranslational modification] 998820006669 UGMP family protein; Validated; Region: PRK09604 998820006670 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 998820006671 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 998820006672 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 998820006673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 998820006674 Coenzyme A binding pocket [chemical binding]; other site 998820006675 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 998820006676 Glycoprotease family; Region: Peptidase_M22; pfam00814 998820006677 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 998820006678 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 998820006679 active site 998820006680 homotetramer interface [polypeptide binding]; other site 998820006681 homodimer interface [polypeptide binding]; other site 998820006682 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 998820006683 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 998820006684 active site 998820006685 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 998820006686 active site 2 [active] 998820006687 active site 1 [active] 998820006688 Predicted methyltransferases [General function prediction only]; Region: COG0313 998820006689 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 998820006690 putative SAM binding site [chemical binding]; other site 998820006691 putative homodimer interface [polypeptide binding]; other site 998820006692 Protein of unknown function (DUF972); Region: DUF972; pfam06156 998820006693 DNA polymerase III subunit delta'; Validated; Region: PRK08058 998820006694 DNA polymerase III subunit delta'; Validated; Region: PRK08485 998820006695 Protein of unknown function (DUF970); Region: DUF970; pfam06153 998820006696 thymidylate kinase; Validated; Region: tmk; PRK00698 998820006697 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 998820006698 TMP-binding site; other site 998820006699 ATP-binding site [chemical binding]; other site 998820006700 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 998820006701 recombination protein RecR; Reviewed; Region: recR; PRK00076 998820006702 RecR protein; Region: RecR; pfam02132 998820006703 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 998820006704 putative active site [active] 998820006705 putative metal-binding site [ion binding]; other site 998820006706 tetramer interface [polypeptide binding]; other site 998820006707 hypothetical protein; Validated; Region: PRK00153 998820006708 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 998820006709 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 998820006710 Walker A motif; other site 998820006711 ATP binding site [chemical binding]; other site 998820006712 Walker B motif; other site 998820006713 arginine finger; other site 998820006714 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 998820006715 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 998820006716 nucleoside/Zn binding site; other site 998820006717 dimer interface [polypeptide binding]; other site 998820006718 catalytic motif [active] 998820006719 Methyltransferase domain; Region: Methyltransf_31; pfam13847 998820006720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 998820006721 S-adenosylmethionine binding site [chemical binding]; other site 998820006722 Predicted integral membrane protein [Function unknown]; Region: COG0392 998820006723 Uncharacterized conserved protein [Function unknown]; Region: COG2898 998820006724 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 998820006725 Transcriptional regulators [Transcription]; Region: PurR; COG1609 998820006726 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 998820006727 DNA binding site [nucleotide binding] 998820006728 domain linker motif; other site 998820006729 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 998820006730 putative dimerization interface [polypeptide binding]; other site 998820006731 putative ligand binding site [chemical binding]; other site 998820006732 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 998820006733 putative active site [active] 998820006734 catalytic triad [active] 998820006735 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 998820006736 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 998820006737 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 998820006738 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 998820006739 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 998820006740 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 998820006741 core dimer interface [polypeptide binding]; other site 998820006742 peripheral dimer interface [polypeptide binding]; other site 998820006743 L10 interface [polypeptide binding]; other site 998820006744 L11 interface [polypeptide binding]; other site 998820006745 putative EF-Tu interaction site [polypeptide binding]; other site 998820006746 putative EF-G interaction site [polypeptide binding]; other site 998820006747 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 998820006748 23S rRNA interface [nucleotide binding]; other site 998820006749 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 998820006750 drug efflux system protein MdtG; Provisional; Region: PRK09874 998820006751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820006752 putative substrate translocation pore; other site 998820006753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820006754 putative substrate translocation pore; other site 998820006755 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 998820006756 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 998820006757 NAD(P) binding site [chemical binding]; other site 998820006758 catalytic residues [active] 998820006759 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 998820006760 mRNA/rRNA interface [nucleotide binding]; other site 998820006761 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 998820006762 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 998820006763 23S rRNA interface [nucleotide binding]; other site 998820006764 L7/L12 interface [polypeptide binding]; other site 998820006765 putative thiostrepton binding site; other site 998820006766 L25 interface [polypeptide binding]; other site 998820006767 magnesium-transporting ATPase; Provisional; Region: PRK15122 998820006768 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 998820006769 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 998820006770 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 998820006771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820006772 motif II; other site 998820006773 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 998820006774 amidase; Provisional; Region: PRK06529 998820006775 Amidase; Region: Amidase; cl11426 998820006776 Domain of unknown function (DU1801); Region: DUF1801; cl17490 998820006777 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 998820006778 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 998820006779 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 998820006780 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 998820006781 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 998820006782 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 998820006783 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 998820006784 putative homodimer interface [polypeptide binding]; other site 998820006785 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 998820006786 heterodimer interface [polypeptide binding]; other site 998820006787 homodimer interface [polypeptide binding]; other site 998820006788 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 998820006789 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 998820006790 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 998820006791 UbiA prenyltransferase family; Region: UbiA; pfam01040 998820006792 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 998820006793 UbiA prenyltransferase family; Region: UbiA; pfam01040 998820006794 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 998820006795 ApbE family; Region: ApbE; pfam02424 998820006796 FMN-binding domain; Region: FMN_bind; cl01081 998820006797 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 998820006798 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 998820006799 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 998820006800 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 998820006801 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 998820006802 trimer interface [polypeptide binding]; other site 998820006803 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 998820006804 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 998820006805 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 998820006806 substrate binding pocket [chemical binding]; other site 998820006807 chain length determination region; other site 998820006808 substrate-Mg2+ binding site; other site 998820006809 catalytic residues [active] 998820006810 aspartate-rich region 1; other site 998820006811 active site lid residues [active] 998820006812 aspartate-rich region 2; other site 998820006813 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 998820006814 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 998820006815 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 998820006816 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 998820006817 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 998820006818 YacP-like NYN domain; Region: NYN_YacP; pfam05991 998820006819 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 998820006820 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 998820006821 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 998820006822 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 998820006823 active site 998820006824 metal binding site [ion binding]; metal-binding site 998820006825 dimerization interface [polypeptide binding]; other site 998820006826 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 998820006827 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 998820006828 active site 998820006829 HIGH motif; other site 998820006830 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 998820006831 KMSKS motif; other site 998820006832 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 998820006833 tRNA binding surface [nucleotide binding]; other site 998820006834 anticodon binding site; other site 998820006835 FAD binding domain; Region: FAD_binding_4; pfam01565 998820006836 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 998820006837 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 998820006838 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 998820006839 active site 998820006840 HIGH motif; other site 998820006841 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 998820006842 active site 998820006843 KMSKS motif; other site 998820006844 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 998820006845 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 998820006846 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 998820006847 tetramer (dimer of dimers) interface [polypeptide binding]; other site 998820006848 active site 998820006849 dimer interface [polypeptide binding]; other site 998820006850 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 998820006851 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 998820006852 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 998820006853 putative active site [active] 998820006854 potential frameshift: common BLAST hit: gi|258540515|ref|YP_003175014.1| membrane protein 998820006855 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 998820006856 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 998820006857 Predicted membrane protein [General function prediction only]; Region: COG4194 998820006858 Predicted transcriptional regulators [Transcription]; Region: COG1725 998820006859 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 998820006860 DNA-binding site [nucleotide binding]; DNA binding site 998820006861 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 998820006862 putative DNA binding site [nucleotide binding]; other site 998820006863 dimerization interface [polypeptide binding]; other site 998820006864 putative Zn2+ binding site [ion binding]; other site 998820006865 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 998820006866 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820006867 Walker A/P-loop; other site 998820006868 ATP binding site [chemical binding]; other site 998820006869 Q-loop/lid; other site 998820006870 ABC transporter signature motif; other site 998820006871 Walker B; other site 998820006872 D-loop; other site 998820006873 H-loop/switch region; other site 998820006874 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 998820006875 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 998820006876 ABC-2 type transporter; Region: ABC2_membrane; cl17235 998820006877 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 998820006878 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 998820006879 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 998820006880 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 998820006881 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 998820006882 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 998820006883 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 998820006884 Walker A/P-loop; other site 998820006885 ATP binding site [chemical binding]; other site 998820006886 Q-loop/lid; other site 998820006887 ABC transporter signature motif; other site 998820006888 Walker B; other site 998820006889 D-loop; other site 998820006890 H-loop/switch region; other site 998820006891 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 998820006892 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 998820006893 non-specific DNA binding site [nucleotide binding]; other site 998820006894 salt bridge; other site 998820006895 sequence-specific DNA binding site [nucleotide binding]; other site 998820006896 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 998820006897 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 998820006898 putative active site [active] 998820006899 DNA repair protein RadA; Provisional; Region: PRK11823 998820006900 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 998820006901 Walker A motif/ATP binding site; other site 998820006902 ATP binding site [chemical binding]; other site 998820006903 Walker B motif; other site 998820006904 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 998820006905 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 998820006906 trimer interface [polypeptide binding]; other site 998820006907 active site 998820006908 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 998820006909 Coenzyme A binding pocket [chemical binding]; other site 998820006910 Protein of unknown function (DUF805); Region: DUF805; pfam05656 998820006911 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 998820006912 trimer interface [polypeptide binding]; other site 998820006913 active site 998820006914 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 998820006915 trimer interface [polypeptide binding]; other site 998820006916 active site 998820006917 G bulge; other site 998820006918 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 998820006919 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820006920 Walker A/P-loop; other site 998820006921 ATP binding site [chemical binding]; other site 998820006922 Q-loop/lid; other site 998820006923 ABC transporter signature motif; other site 998820006924 Walker B; other site 998820006925 D-loop; other site 998820006926 H-loop/switch region; other site 998820006927 K+ potassium transporter; Region: K_trans; pfam02705 998820006928 pyruvate phosphate dikinase; Provisional; Region: PRK09279 998820006929 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 998820006930 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 998820006931 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 998820006932 HTH domain; Region: HTH_11; pfam08279 998820006933 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 998820006934 FOG: CBS domain [General function prediction only]; Region: COG0517 998820006935 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 998820006936 catalytic core [active] 998820006937 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 998820006938 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 998820006939 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 998820006940 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 998820006941 teramer interface [polypeptide binding]; other site 998820006942 active site 998820006943 FMN binding site [chemical binding]; other site 998820006944 catalytic residues [active] 998820006945 CsbD-like; Region: CsbD; pfam05532 998820006946 phosphopentomutase; Provisional; Region: PRK05362 998820006947 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 998820006948 benzoate transport; Region: 2A0115; TIGR00895 998820006949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820006950 putative substrate translocation pore; other site 998820006951 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 998820006952 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 998820006953 benzoate transport; Region: 2A0115; TIGR00895 998820006954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820006955 putative substrate translocation pore; other site 998820006956 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 998820006957 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 998820006958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820006959 H+ Antiporter protein; Region: 2A0121; TIGR00900 998820006960 putative substrate translocation pore; other site 998820006961 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 998820006962 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 998820006963 putative catalytic cysteine [active] 998820006964 gamma-glutamyl kinase; Provisional; Region: PRK05429 998820006965 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 998820006966 nucleotide binding site [chemical binding]; other site 998820006967 homotetrameric interface [polypeptide binding]; other site 998820006968 putative phosphate binding site [ion binding]; other site 998820006969 putative allosteric binding site; other site 998820006970 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 998820006971 active site 998820006972 catalytic site [active] 998820006973 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 998820006974 Cna protein B-type domain; Region: Cna_B; pfam05738 998820006975 Cna protein B-type domain; Region: Cna_B; pfam05738 998820006976 Cna protein B-type domain; Region: Cna_B; pfam05738 998820006977 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 998820006978 Uncharacterized conserved protein [Function unknown]; Region: COG3410 998820006979 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 998820006980 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 998820006981 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 998820006982 non-specific DNA binding site [nucleotide binding]; other site 998820006983 salt bridge; other site 998820006984 sequence-specific DNA binding site [nucleotide binding]; other site 998820006985 Predicted transcriptional regulators [Transcription]; Region: COG1695 998820006986 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 998820006987 Enterocin A Immunity; Region: EntA_Immun; pfam08951 998820006988 Enterocin A Immunity; Region: EntA_Immun; pfam08951 998820006989 Enterocin A Immunity; Region: EntA_Immun; pfam08951 998820006990 Uncharacterized conserved protein [Function unknown]; Region: COG2966 998820006991 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 998820006992 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 998820006993 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 998820006994 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 998820006995 HlyD family secretion protein; Region: HlyD_3; pfam13437 998820006996 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 998820006997 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 998820006998 putative active site [active] 998820006999 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 998820007000 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820007001 Walker A/P-loop; other site 998820007002 ATP binding site [chemical binding]; other site 998820007003 Q-loop/lid; other site 998820007004 ABC transporter signature motif; other site 998820007005 Walker B; other site 998820007006 D-loop; other site 998820007007 H-loop/switch region; other site 998820007008 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 998820007009 putative active site [active] 998820007010 sensory histidine kinase DcuS; Provisional; Region: PRK11086 998820007011 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 998820007012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 998820007013 active site 998820007014 phosphorylation site [posttranslational modification] 998820007015 intermolecular recognition site; other site 998820007016 dimerization interface [polypeptide binding]; other site 998820007017 LytTr DNA-binding domain; Region: LytTR; pfam04397 998820007018 CAAX protease self-immunity; Region: Abi; pfam02517 998820007019 CAAX protease self-immunity; Region: Abi; pfam02517 998820007020 Enterocin A Immunity; Region: EntA_Immun; pfam08951 998820007021 maltose O-acetyltransferase; Provisional; Region: PRK10092 998820007022 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 998820007023 active site 998820007024 substrate binding site [chemical binding]; other site 998820007025 trimer interface [polypeptide binding]; other site 998820007026 CoA binding site [chemical binding]; other site 998820007027 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 998820007028 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 998820007029 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 998820007030 active site 998820007031 catalytic tetrad [active] 998820007032 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 998820007033 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 998820007034 NAD(P) binding site [chemical binding]; other site 998820007035 active site 998820007036 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 998820007037 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 998820007038 putative active site [active] 998820007039 putative FMN binding site [chemical binding]; other site 998820007040 putative substrate binding site [chemical binding]; other site 998820007041 putative catalytic residue [active] 998820007042 fumarate hydratase; Reviewed; Region: fumC; PRK00485 998820007043 Class II fumarases; Region: Fumarase_classII; cd01362 998820007044 active site 998820007045 tetramer interface [polypeptide binding]; other site 998820007046 manganese transport protein MntH; Reviewed; Region: PRK00701 998820007047 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 998820007048 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 998820007049 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 998820007050 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 998820007051 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 998820007052 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820007053 motif II; other site 998820007054 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 998820007055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820007056 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 998820007057 putative substrate translocation pore; other site 998820007058 multicopper oxidase; Provisional; Region: PRK10965 998820007059 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 998820007060 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 998820007061 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 998820007062 Cation efflux family; Region: Cation_efflux; cl00316 998820007063 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 998820007064 dimerization interface [polypeptide binding]; other site 998820007065 putative DNA binding site [nucleotide binding]; other site 998820007066 putative Zn2+ binding site [ion binding]; other site 998820007067 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 998820007068 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 998820007069 metal binding site [ion binding]; metal-binding site 998820007070 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 998820007071 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 998820007072 ABC-ATPase subunit interface; other site 998820007073 dimer interface [polypeptide binding]; other site 998820007074 putative PBP binding regions; other site 998820007075 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 998820007076 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 998820007077 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 998820007078 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 998820007079 NAD binding site [chemical binding]; other site 998820007080 catalytic residues [active] 998820007081 substrate binding site [chemical binding]; other site 998820007082 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 998820007083 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 998820007084 Helix-turn-helix domain; Region: HTH_38; pfam13936 998820007085 Integrase core domain; Region: rve; pfam00665 998820007086 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 998820007087 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 998820007088 metal binding site [ion binding]; metal-binding site 998820007089 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 998820007090 NADH(P)-binding; Region: NAD_binding_10; pfam13460 998820007091 putative NAD(P) binding site [chemical binding]; other site 998820007092 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 998820007093 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 998820007094 nudix motif; other site 998820007095 Collagen binding domain; Region: Collagen_bind; pfam05737 998820007096 Cna protein B-type domain; Region: Cna_B; pfam05738 998820007097 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 998820007098 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 998820007099 metal binding site [ion binding]; metal-binding site 998820007100 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 998820007101 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 998820007102 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 998820007103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 998820007104 Walker A motif; other site 998820007105 ATP binding site [chemical binding]; other site 998820007106 Walker B motif; other site 998820007107 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 998820007108 Enolase, N-terminal domain; Region: Enolase_N; pfam03952 998820007109 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 998820007110 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 998820007111 membrane-bound complex binding site; other site 998820007112 hinge residues; other site 998820007113 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 998820007114 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 998820007115 Walker A/P-loop; other site 998820007116 ATP binding site [chemical binding]; other site 998820007117 Q-loop/lid; other site 998820007118 ABC transporter signature motif; other site 998820007119 Walker B; other site 998820007120 D-loop; other site 998820007121 H-loop/switch region; other site 998820007122 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 998820007123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820007124 dimer interface [polypeptide binding]; other site 998820007125 conserved gate region; other site 998820007126 putative PBP binding loops; other site 998820007127 ABC-ATPase subunit interface; other site 998820007128 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 998820007129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820007130 dimer interface [polypeptide binding]; other site 998820007131 conserved gate region; other site 998820007132 putative PBP binding loops; other site 998820007133 ABC-ATPase subunit interface; other site 998820007134 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 998820007135 Helix-turn-helix domain; Region: HTH_38; pfam13936 998820007136 Integrase core domain; Region: rve; pfam00665 998820007137 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 998820007138 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 998820007139 substrate binding pocket [chemical binding]; other site 998820007140 membrane-bound complex binding site; other site 998820007141 hinge residues; other site 998820007142 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 998820007143 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 998820007144 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 998820007145 acyl-activating enzyme (AAE) consensus motif; other site 998820007146 acyl-activating enzyme (AAE) consensus motif; other site 998820007147 putative AMP binding site [chemical binding]; other site 998820007148 putative active site [active] 998820007149 putative CoA binding site [chemical binding]; other site 998820007150 Acyltransferase family; Region: Acyl_transf_3; pfam01757 998820007151 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 998820007152 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820007153 Walker A/P-loop; other site 998820007154 ATP binding site [chemical binding]; other site 998820007155 Q-loop/lid; other site 998820007156 ABC transporter signature motif; other site 998820007157 Walker B; other site 998820007158 D-loop; other site 998820007159 H-loop/switch region; other site 998820007160 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 998820007161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820007162 putative PBP binding loops; other site 998820007163 dimer interface [polypeptide binding]; other site 998820007164 ABC-ATPase subunit interface; other site 998820007165 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 998820007166 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 998820007167 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 998820007168 ABC transporter; Region: ABC_tran; pfam00005 998820007169 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820007170 Q-loop/lid; other site 998820007171 ABC transporter signature motif; other site 998820007172 Walker B; other site 998820007173 D-loop; other site 998820007174 H-loop/switch region; other site 998820007175 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 998820007176 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 998820007177 23S rRNA interface [nucleotide binding]; other site 998820007178 L3 interface [polypeptide binding]; other site 998820007179 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 998820007180 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 998820007181 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 998820007182 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 998820007183 Walker A/P-loop; other site 998820007184 ATP binding site [chemical binding]; other site 998820007185 Q-loop/lid; other site 998820007186 ABC transporter signature motif; other site 998820007187 Walker B; other site 998820007188 D-loop; other site 998820007189 H-loop/switch region; other site 998820007190 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 998820007191 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 998820007192 DNA binding residues [nucleotide binding] 998820007193 dimer interface [polypeptide binding]; other site 998820007194 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 998820007195 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 998820007196 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 998820007197 dimerization interface 3.5A [polypeptide binding]; other site 998820007198 active site 998820007199 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 998820007200 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 998820007201 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 998820007202 Walker A/P-loop; other site 998820007203 ATP binding site [chemical binding]; other site 998820007204 Q-loop/lid; other site 998820007205 ABC transporter signature motif; other site 998820007206 Walker B; other site 998820007207 D-loop; other site 998820007208 H-loop/switch region; other site 998820007209 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 998820007210 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 998820007211 Walker A/P-loop; other site 998820007212 ATP binding site [chemical binding]; other site 998820007213 Q-loop/lid; other site 998820007214 ABC transporter signature motif; other site 998820007215 Walker B; other site 998820007216 D-loop; other site 998820007217 H-loop/switch region; other site 998820007218 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 998820007219 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 998820007220 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 998820007221 alphaNTD homodimer interface [polypeptide binding]; other site 998820007222 alphaNTD - beta interaction site [polypeptide binding]; other site 998820007223 alphaNTD - beta' interaction site [polypeptide binding]; other site 998820007224 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 998820007225 30S ribosomal protein S11; Validated; Region: PRK05309 998820007226 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 998820007227 30S ribosomal protein S13; Region: bact_S13; TIGR03631 998820007228 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 998820007229 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 998820007230 rRNA binding site [nucleotide binding]; other site 998820007231 predicted 30S ribosome binding site; other site 998820007232 adenylate kinase; Reviewed; Region: adk; PRK00279 998820007233 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 998820007234 AMP-binding site [chemical binding]; other site 998820007235 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 998820007236 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 998820007237 SecY translocase; Region: SecY; pfam00344 998820007238 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 998820007239 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 998820007240 23S rRNA binding site [nucleotide binding]; other site 998820007241 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 998820007242 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 998820007243 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 998820007244 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 998820007245 5S rRNA interface [nucleotide binding]; other site 998820007246 L27 interface [polypeptide binding]; other site 998820007247 23S rRNA interface [nucleotide binding]; other site 998820007248 L5 interface [polypeptide binding]; other site 998820007249 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 998820007250 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 998820007251 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 998820007252 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 998820007253 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 998820007254 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 998820007255 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 998820007256 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 998820007257 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 998820007258 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 998820007259 RNA binding site [nucleotide binding]; other site 998820007260 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 998820007261 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 998820007262 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 998820007263 23S rRNA interface [nucleotide binding]; other site 998820007264 putative translocon interaction site; other site 998820007265 signal recognition particle (SRP54) interaction site; other site 998820007266 L23 interface [polypeptide binding]; other site 998820007267 trigger factor interaction site; other site 998820007268 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 998820007269 23S rRNA interface [nucleotide binding]; other site 998820007270 5S rRNA interface [nucleotide binding]; other site 998820007271 putative antibiotic binding site [chemical binding]; other site 998820007272 L25 interface [polypeptide binding]; other site 998820007273 L27 interface [polypeptide binding]; other site 998820007274 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 998820007275 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 998820007276 G-X-X-G motif; other site 998820007277 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 998820007278 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 998820007279 putative translocon binding site; other site 998820007280 protein-rRNA interface [nucleotide binding]; other site 998820007281 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 998820007282 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 998820007283 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 998820007284 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 998820007285 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 998820007286 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 998820007287 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 998820007288 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 998820007289 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 998820007290 peroxiredoxin; Region: AhpC; TIGR03137 998820007291 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 998820007292 dimer interface [polypeptide binding]; other site 998820007293 decamer (pentamer of dimers) interface [polypeptide binding]; other site 998820007294 catalytic triad [active] 998820007295 peroxidatic and resolving cysteines [active] 998820007296 Predicted transcriptional regulator [Transcription]; Region: COG2378 998820007297 WYL domain; Region: WYL; pfam13280 998820007298 elongation factor G; Reviewed; Region: PRK12739 998820007299 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 998820007300 G1 box; other site 998820007301 putative GEF interaction site [polypeptide binding]; other site 998820007302 GTP/Mg2+ binding site [chemical binding]; other site 998820007303 Switch I region; other site 998820007304 G2 box; other site 998820007305 G3 box; other site 998820007306 Switch II region; other site 998820007307 G4 box; other site 998820007308 G5 box; other site 998820007309 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 998820007310 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 998820007311 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 998820007312 30S ribosomal protein S7; Validated; Region: PRK05302 998820007313 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 998820007314 S17 interaction site [polypeptide binding]; other site 998820007315 S8 interaction site; other site 998820007316 16S rRNA interaction site [nucleotide binding]; other site 998820007317 streptomycin interaction site [chemical binding]; other site 998820007318 23S rRNA interaction site [nucleotide binding]; other site 998820007319 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 998820007320 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 998820007321 Cna protein B-type domain; Region: Cna_B; pfam05738 998820007322 Cna protein B-type domain; Region: Cna_B; pfam05738 998820007323 Cna protein B-type domain; Region: Cna_B; pfam05738 998820007324 Cna protein B-type domain; Region: Cna_B; pfam05738 998820007325 Cna protein B-type domain; Region: Cna_B; pfam05738 998820007326 Cna protein B-type domain; Region: Cna_B; pfam05738 998820007327 Cna protein B-type domain; Region: Cna_B; pfam05738 998820007328 Cna protein B-type domain; Region: Cna_B; pfam05738 998820007329 Cna protein B-type domain; Region: Cna_B; pfam05738 998820007330 Cna protein B-type domain; Region: Cna_B; pfam05738 998820007331 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 998820007332 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 998820007333 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 998820007334 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 998820007335 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 998820007336 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 998820007337 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 998820007338 DNA binding site [nucleotide binding] 998820007339 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 998820007340 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 998820007341 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 998820007342 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 998820007343 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 998820007344 RPB1 interaction site [polypeptide binding]; other site 998820007345 RPB10 interaction site [polypeptide binding]; other site 998820007346 RPB11 interaction site [polypeptide binding]; other site 998820007347 RPB3 interaction site [polypeptide binding]; other site 998820007348 RPB12 interaction site [polypeptide binding]; other site 998820007349 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 998820007350 Clp amino terminal domain; Region: Clp_N; pfam02861 998820007351 Clp amino terminal domain; Region: Clp_N; pfam02861 998820007352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 998820007353 Walker A motif; other site 998820007354 ATP binding site [chemical binding]; other site 998820007355 Walker B motif; other site 998820007356 arginine finger; other site 998820007357 UvrB/uvrC motif; Region: UVR; pfam02151 998820007358 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 998820007359 Walker A motif; other site 998820007360 ATP binding site [chemical binding]; other site 998820007361 Walker B motif; other site 998820007362 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 998820007363 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 998820007364 Domain of unknown function (DUF4323); Region: DUF4323; pfam14211 998820007365 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 998820007366 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 998820007367 dimer interface [polypeptide binding]; other site 998820007368 putative anticodon binding site; other site 998820007369 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 998820007370 motif 1; other site 998820007371 active site 998820007372 motif 2; other site 998820007373 motif 3; other site 998820007374 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 998820007375 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 998820007376 FMN binding site [chemical binding]; other site 998820007377 active site 998820007378 catalytic residues [active] 998820007379 substrate binding site [chemical binding]; other site 998820007380 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 998820007381 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 998820007382 dimerization interface [polypeptide binding]; other site 998820007383 domain crossover interface; other site 998820007384 redox-dependent activation switch; other site 998820007385 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 998820007386 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 998820007387 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 998820007388 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 998820007389 legume lectins; Region: lectin_L-type; cl14058 998820007390 homotetramer interaction site [polypeptide binding]; other site 998820007391 homodimer interaction site [polypeptide binding]; other site 998820007392 carbohydrate binding site [chemical binding]; other site 998820007393 metal binding site [ion binding]; metal-binding site 998820007394 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 998820007395 WxL domain surface cell wall-binding; Region: WxL; pfam13731 998820007396 FtsH Extracellular; Region: FtsH_ext; pfam06480 998820007397 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 998820007398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 998820007399 Walker A motif; other site 998820007400 ATP binding site [chemical binding]; other site 998820007401 Walker B motif; other site 998820007402 arginine finger; other site 998820007403 Peptidase family M41; Region: Peptidase_M41; pfam01434 998820007404 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 998820007405 active site 998820007406 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 998820007407 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 998820007408 Ligand Binding Site [chemical binding]; other site 998820007409 TilS substrate C-terminal domain; Region: TilS_C; smart00977 998820007410 hypothetical protein; Provisional; Region: PRK08582 998820007411 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 998820007412 RNA binding site [nucleotide binding]; other site 998820007413 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 998820007414 Septum formation initiator; Region: DivIC; pfam04977 998820007415 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 998820007416 RNA binding surface [nucleotide binding]; other site 998820007417 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 998820007418 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 998820007419 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 998820007420 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 998820007421 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 998820007422 ATP binding site [chemical binding]; other site 998820007423 putative Mg++ binding site [ion binding]; other site 998820007424 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 998820007425 nucleotide binding region [chemical binding]; other site 998820007426 ATP-binding site [chemical binding]; other site 998820007427 TRCF domain; Region: TRCF; pfam03461 998820007428 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 998820007429 putative active site [active] 998820007430 catalytic residue [active] 998820007431 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 998820007432 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 998820007433 tetramer (dimer of dimers) interface [polypeptide binding]; other site 998820007434 NAD binding site [chemical binding]; other site 998820007435 dimer interface [polypeptide binding]; other site 998820007436 substrate binding site [chemical binding]; other site 998820007437 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 998820007438 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 998820007439 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 998820007440 Predicted transcriptional regulators [Transcription]; Region: COG1695 998820007441 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 998820007442 Predicted membrane protein [Function unknown]; Region: COG1511 998820007443 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 998820007444 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 998820007445 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 998820007446 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 998820007447 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 998820007448 FOG: CBS domain [General function prediction only]; Region: COG0517 998820007449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 998820007450 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 998820007451 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 998820007452 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 998820007453 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 998820007454 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 998820007455 active site 998820007456 dimer interface [polypeptide binding]; other site 998820007457 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 998820007458 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 998820007459 active site 998820007460 FMN binding site [chemical binding]; other site 998820007461 substrate binding site [chemical binding]; other site 998820007462 3Fe-4S cluster binding site [ion binding]; other site 998820007463 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 998820007464 domain interface; other site 998820007465 QueT transporter; Region: QueT; pfam06177 998820007466 PemK-like protein; Region: PemK; pfam02452 998820007467 hypothetical protein; Region: PHA01623 998820007468 alanine racemase; Reviewed; Region: alr; PRK00053 998820007469 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 998820007470 active site 998820007471 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 998820007472 dimer interface [polypeptide binding]; other site 998820007473 substrate binding site [chemical binding]; other site 998820007474 catalytic residues [active] 998820007475 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 998820007476 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 998820007477 DEAD-like helicases superfamily; Region: DEXDc; smart00487 998820007478 ATP binding site [chemical binding]; other site 998820007479 Mg++ binding site [ion binding]; other site 998820007480 motif III; other site 998820007481 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 998820007482 nucleotide binding region [chemical binding]; other site 998820007483 ATP-binding site [chemical binding]; other site 998820007484 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 998820007485 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 998820007486 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 998820007487 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 998820007488 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 998820007489 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 998820007490 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 998820007491 hinge; other site 998820007492 active site 998820007493 CTP synthetase; Validated; Region: pyrG; PRK05380 998820007494 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 998820007495 Catalytic site [active] 998820007496 active site 998820007497 UTP binding site [chemical binding]; other site 998820007498 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 998820007499 active site 998820007500 putative oxyanion hole; other site 998820007501 catalytic triad [active] 998820007502 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 998820007503 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 998820007504 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 998820007505 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 998820007506 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 998820007507 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 998820007508 Zn2+ binding site [ion binding]; other site 998820007509 Mg2+ binding site [ion binding]; other site 998820007510 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 998820007511 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 998820007512 putative active site [active] 998820007513 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 998820007514 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 998820007515 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 998820007516 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 998820007517 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 998820007518 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 998820007519 active site 998820007520 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 998820007521 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 998820007522 Substrate binding site; other site 998820007523 Mg++ binding site; other site 998820007524 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 998820007525 active site 998820007526 substrate binding site [chemical binding]; other site 998820007527 CoA binding site [chemical binding]; other site 998820007528 VanZ like family; Region: VanZ; pfam04892 998820007529 RDD family; Region: RDD; pfam06271 998820007530 pur operon repressor; Provisional; Region: PRK09213 998820007531 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 998820007532 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 998820007533 active site 998820007534 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 998820007535 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 998820007536 Walker A/P-loop; other site 998820007537 ATP binding site [chemical binding]; other site 998820007538 Q-loop/lid; other site 998820007539 ABC transporter signature motif; other site 998820007540 Walker B; other site 998820007541 D-loop; other site 998820007542 H-loop/switch region; other site 998820007543 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 998820007544 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 998820007545 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 998820007546 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 998820007547 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 998820007548 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 998820007549 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 998820007550 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 998820007551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 998820007552 S-adenosylmethionine binding site [chemical binding]; other site 998820007553 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 998820007554 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 998820007555 putative active site [active] 998820007556 putative metal binding site [ion binding]; other site 998820007557 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 998820007558 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 998820007559 active site 998820007560 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 998820007561 active site 998820007562 phosphorylation site [posttranslational modification] 998820007563 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 998820007564 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 998820007565 active site 998820007566 catalytic residues [active] 998820007567 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 998820007568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 998820007569 active site 998820007570 phosphorylation site [posttranslational modification] 998820007571 intermolecular recognition site; other site 998820007572 dimerization interface [polypeptide binding]; other site 998820007573 LytTr DNA-binding domain; Region: LytTR; smart00850 998820007574 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 998820007575 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 998820007576 ATP binding site [chemical binding]; other site 998820007577 Mg2+ binding site [ion binding]; other site 998820007578 G-X-G motif; other site 998820007579 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 998820007580 Transmembrane protein 231; Region: TM231; pfam10149 998820007581 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820007582 Walker A/P-loop; other site 998820007583 ATP binding site [chemical binding]; other site 998820007584 Q-loop/lid; other site 998820007585 ABC transporter signature motif; other site 998820007586 Walker B; other site 998820007587 D-loop; other site 998820007588 H-loop/switch region; other site 998820007589 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 998820007590 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820007591 Walker A/P-loop; other site 998820007592 ATP binding site [chemical binding]; other site 998820007593 Q-loop/lid; other site 998820007594 ABC transporter signature motif; other site 998820007595 Walker B; other site 998820007596 D-loop; other site 998820007597 H-loop/switch region; other site 998820007598 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 998820007599 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 998820007600 active site 998820007601 HIGH motif; other site 998820007602 KMSKS motif; other site 998820007603 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 998820007604 tRNA binding surface [nucleotide binding]; other site 998820007605 anticodon binding site; other site 998820007606 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 998820007607 dimer interface [polypeptide binding]; other site 998820007608 putative tRNA-binding site [nucleotide binding]; other site 998820007609 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 998820007610 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 998820007611 Protein of unknown function DUF72; Region: DUF72; pfam01904 998820007612 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 998820007613 putative active site [active] 998820007614 nucleotide binding site [chemical binding]; other site 998820007615 nudix motif; other site 998820007616 putative metal binding site [ion binding]; other site 998820007617 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 998820007618 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 998820007619 LDH/MDH dimer interface [polypeptide binding]; other site 998820007620 NAD(P) binding site [chemical binding]; other site 998820007621 substrate binding site [chemical binding]; other site 998820007622 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 998820007623 NAD-dependent deacetylase; Provisional; Region: PRK00481 998820007624 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 998820007625 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 998820007626 substrate binding site [chemical binding]; other site 998820007627 Predicted secreted protein [Function unknown]; Region: COG4086 998820007628 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 998820007629 exopolyphosphatase; Region: exo_poly_only; TIGR03706 998820007630 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 998820007631 polyphosphate kinase; Provisional; Region: PRK05443 998820007632 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 998820007633 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 998820007634 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 998820007635 putative domain interface [polypeptide binding]; other site 998820007636 putative active site [active] 998820007637 catalytic site [active] 998820007638 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 998820007639 putative domain interface [polypeptide binding]; other site 998820007640 putative active site [active] 998820007641 catalytic site [active] 998820007642 exopolyphosphatase; Region: exo_poly_only; TIGR03706 998820007643 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 998820007644 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 998820007645 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 998820007646 active site 998820007647 catalytic tetrad [active] 998820007648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 998820007649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 998820007650 S-adenosylmethionine binding site [chemical binding]; other site 998820007651 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 998820007652 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 998820007653 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 998820007654 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 998820007655 Repair protein; Region: Repair_PSII; pfam04536 998820007656 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 998820007657 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 998820007658 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 998820007659 active site 998820007660 HIGH motif; other site 998820007661 dimer interface [polypeptide binding]; other site 998820007662 KMSKS motif; other site 998820007663 FtsX-like permease family; Region: FtsX; pfam02687 998820007664 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 998820007665 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 998820007666 Walker A/P-loop; other site 998820007667 ATP binding site [chemical binding]; other site 998820007668 Q-loop/lid; other site 998820007669 ABC transporter signature motif; other site 998820007670 Walker B; other site 998820007671 D-loop; other site 998820007672 H-loop/switch region; other site 998820007673 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 998820007674 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 998820007675 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 998820007676 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 998820007677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820007678 Walker A/P-loop; other site 998820007679 ATP binding site [chemical binding]; other site 998820007680 Q-loop/lid; other site 998820007681 ABC transporter signature motif; other site 998820007682 Walker B; other site 998820007683 D-loop; other site 998820007684 H-loop/switch region; other site 998820007685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820007686 conserved gate region; other site 998820007687 ABC-ATPase subunit interface; other site 998820007688 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 998820007689 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 998820007690 Part of AAA domain; Region: AAA_19; pfam13245 998820007691 Family description; Region: UvrD_C_2; pfam13538 998820007692 Transcriptional regulator [Transcription]; Region: LysR; COG0583 998820007693 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 998820007694 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 998820007695 dimerization interface [polypeptide binding]; other site 998820007696 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 998820007697 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 998820007698 gating phenylalanine in ion channel; other site 998820007699 CAAX protease self-immunity; Region: Abi; pfam02517 998820007700 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 998820007701 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 998820007702 Zn2+ binding site [ion binding]; other site 998820007703 Mg2+ binding site [ion binding]; other site 998820007704 Transcriptional regulators [Transcription]; Region: MarR; COG1846 998820007705 MarR family; Region: MarR; pfam01047 998820007706 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820007707 Walker A/P-loop; other site 998820007708 ATP binding site [chemical binding]; other site 998820007709 Q-loop/lid; other site 998820007710 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 998820007711 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 998820007712 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820007713 ABC transporter signature motif; other site 998820007714 Walker B; other site 998820007715 D-loop; other site 998820007716 H-loop/switch region; other site 998820007717 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820007718 Walker A/P-loop; other site 998820007719 ATP binding site [chemical binding]; other site 998820007720 Q-loop/lid; other site 998820007721 ABC transporter signature motif; other site 998820007722 Walker B; other site 998820007723 D-loop; other site 998820007724 H-loop/switch region; other site 998820007725 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 998820007726 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 998820007727 active site 998820007728 catalytic tetrad [active] 998820007729 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 998820007730 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820007731 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 998820007732 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 998820007733 catalytic core [active] 998820007734 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 998820007735 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820007736 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 998820007737 active site 998820007738 motif I; other site 998820007739 motif II; other site 998820007740 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 998820007741 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 998820007742 RNA/DNA hybrid binding site [nucleotide binding]; other site 998820007743 active site 998820007744 Transcriptional regulator [Transcription]; Region: LysR; COG0583 998820007745 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 998820007746 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 998820007747 dimerization interface [polypeptide binding]; other site 998820007748 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 998820007749 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 998820007750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 998820007751 homodimer interface [polypeptide binding]; other site 998820007752 catalytic residue [active] 998820007753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820007754 Major Facilitator Superfamily; Region: MFS_1; pfam07690 998820007755 putative substrate translocation pore; other site 998820007756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820007757 putative substrate translocation pore; other site 998820007758 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 998820007759 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 998820007760 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 998820007761 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 998820007762 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 998820007763 hexamer interface [polypeptide binding]; other site 998820007764 Walker A motif; other site 998820007765 ATP binding site [chemical binding]; other site 998820007766 Walker B motif; other site 998820007767 Protein of unknown function (DUF554); Region: DUF554; pfam04474 998820007768 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 998820007769 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 998820007770 active site 998820007771 P-loop; other site 998820007772 phosphorylation site [posttranslational modification] 998820007773 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 998820007774 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 998820007775 active site 998820007776 phosphorylation site [posttranslational modification] 998820007777 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 998820007778 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 998820007779 putative substrate binding site [chemical binding]; other site 998820007780 putative ATP binding site [chemical binding]; other site 998820007781 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 998820007782 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 998820007783 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 998820007784 putative active site [active] 998820007785 glycerol kinase; Provisional; Region: glpK; PRK00047 998820007786 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 998820007787 N- and C-terminal domain interface [polypeptide binding]; other site 998820007788 active site 998820007789 MgATP binding site [chemical binding]; other site 998820007790 catalytic site [active] 998820007791 metal binding site [ion binding]; metal-binding site 998820007792 glycerol binding site [chemical binding]; other site 998820007793 homotetramer interface [polypeptide binding]; other site 998820007794 homodimer interface [polypeptide binding]; other site 998820007795 FBP binding site [chemical binding]; other site 998820007796 protein IIAGlc interface [polypeptide binding]; other site 998820007797 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 998820007798 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 998820007799 DNA-binding site [nucleotide binding]; DNA binding site 998820007800 UTRA domain; Region: UTRA; cl17743 998820007801 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 998820007802 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 998820007803 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 998820007804 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 998820007805 active pocket/dimerization site; other site 998820007806 active site 998820007807 phosphorylation site [posttranslational modification] 998820007808 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 998820007809 active site 998820007810 phosphorylation site [posttranslational modification] 998820007811 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 998820007812 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 998820007813 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 998820007814 active site 998820007815 methionine cluster; other site 998820007816 phosphorylation site [posttranslational modification] 998820007817 metal binding site [ion binding]; metal-binding site 998820007818 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 998820007819 active site 998820007820 P-loop; other site 998820007821 phosphorylation site [posttranslational modification] 998820007822 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 998820007823 beta-galactosidase; Region: BGL; TIGR03356 998820007824 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 998820007825 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 998820007826 nucleotide binding site [chemical binding]; other site 998820007827 Uncharacterized conserved protein [Function unknown]; Region: COG3538 998820007828 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 998820007829 alpha-mannosidase; Provisional; Region: PRK09819 998820007830 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 998820007831 active site 998820007832 metal binding site [ion binding]; metal-binding site 998820007833 catalytic site [active] 998820007834 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 998820007835 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 998820007836 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 998820007837 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 998820007838 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 998820007839 DNA-binding site [nucleotide binding]; DNA binding site 998820007840 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 998820007841 hypothetical protein; Provisional; Region: PRK06357 998820007842 intersubunit interface [polypeptide binding]; other site 998820007843 active site 998820007844 Zn2+ binding site [ion binding]; other site 998820007845 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 998820007846 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 998820007847 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 998820007848 active site 998820007849 P-loop; other site 998820007850 phosphorylation site [posttranslational modification] 998820007851 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 998820007852 active site 998820007853 phosphorylation site [posttranslational modification] 998820007854 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 998820007855 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 998820007856 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 998820007857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 998820007858 S-adenosylmethionine binding site [chemical binding]; other site 998820007859 Methyltransferase domain; Region: Methyltransf_31; pfam13847 998820007860 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 998820007861 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 998820007862 Ca binding site [ion binding]; other site 998820007863 active site 998820007864 catalytic site [active] 998820007865 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 998820007866 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 998820007867 Preprotein translocase subunit; Region: YajC; pfam02699 998820007868 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 998820007869 active pocket/dimerization site; other site 998820007870 active site 998820007871 phosphorylation site [posttranslational modification] 998820007872 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 998820007873 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 998820007874 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 998820007875 active site 998820007876 phosphorylation site [posttranslational modification] 998820007877 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 998820007878 Transcriptional regulator [Transcription]; Region: IclR; COG1414 998820007879 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 998820007880 Bacterial transcriptional regulator; Region: IclR; pfam01614 998820007881 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 998820007882 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 998820007883 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 998820007884 NADP binding site [chemical binding]; other site 998820007885 homodimer interface [polypeptide binding]; other site 998820007886 active site 998820007887 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 998820007888 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 998820007889 active site 998820007890 intersubunit interface [polypeptide binding]; other site 998820007891 catalytic residue [active] 998820007892 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 998820007893 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 998820007894 substrate binding site [chemical binding]; other site 998820007895 ATP binding site [chemical binding]; other site 998820007896 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 998820007897 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 998820007898 active site 998820007899 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 998820007900 tetramer (dimer of dimers) interface [polypeptide binding]; other site 998820007901 active site 998820007902 dimer interface [polypeptide binding]; other site 998820007903 conserved hypothetical integral membrane protein; Region: TIGR03766 998820007904 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 998820007905 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 998820007906 Ligand binding site; other site 998820007907 Putative Catalytic site; other site 998820007908 DXD motif; other site 998820007909 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 998820007910 active site 998820007911 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 998820007912 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 998820007913 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 998820007914 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 998820007915 HAMP domain; Region: HAMP; pfam00672 998820007916 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 998820007917 dimer interface [polypeptide binding]; other site 998820007918 phosphorylation site [posttranslational modification] 998820007919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 998820007920 ATP binding site [chemical binding]; other site 998820007921 Mg2+ binding site [ion binding]; other site 998820007922 G-X-G motif; other site 998820007923 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 998820007924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 998820007925 active site 998820007926 phosphorylation site [posttranslational modification] 998820007927 intermolecular recognition site; other site 998820007928 dimerization interface [polypeptide binding]; other site 998820007929 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 998820007930 DNA binding site [nucleotide binding] 998820007931 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 998820007932 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 998820007933 NAD binding site [chemical binding]; other site 998820007934 sugar binding site [chemical binding]; other site 998820007935 divalent metal binding site [ion binding]; other site 998820007936 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 998820007937 dimer interface [polypeptide binding]; other site 998820007938 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 998820007939 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 998820007940 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 998820007941 active site turn [active] 998820007942 phosphorylation site [posttranslational modification] 998820007943 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 998820007944 substrate binding site [chemical binding]; other site 998820007945 catalytic residues [active] 998820007946 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 998820007947 Helix-turn-helix domain; Region: HTH_38; pfam13936 998820007948 Integrase core domain; Region: rve; pfam00665 998820007949 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 998820007950 Mga helix-turn-helix domain; Region: Mga; pfam05043 998820007951 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 998820007952 Homeodomain-like domain; Region: HTH_23; cl17451 998820007953 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 998820007954 Transposase; Region: HTH_Tnp_1; cl17663 998820007955 Helix-turn-helix domain; Region: HTH_28; pfam13518 998820007956 putative transposase OrfB; Reviewed; Region: PHA02517 998820007957 HTH-like domain; Region: HTH_21; pfam13276 998820007958 Integrase core domain; Region: rve; pfam00665 998820007959 Integrase core domain; Region: rve_3; pfam13683 998820007960 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 998820007961 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 998820007962 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 998820007963 putative active site [active] 998820007964 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 998820007965 HPr interaction site; other site 998820007966 glycerol kinase (GK) interaction site [polypeptide binding]; other site 998820007967 active site 998820007968 phosphorylation site [posttranslational modification] 998820007969 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 998820007970 Uncharacterized conserved protein [Function unknown]; Region: COG1434 998820007971 putative active site [active] 998820007972 Protein of unknown function (DUF1341); Region: DUF1341; pfam07071 998820007973 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 998820007974 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 998820007975 dihydroorotase; Provisional; Region: PRK09237 998820007976 active site 998820007977 Domain of unknown function (DUF4310); Region: DUF4310; pfam14187 998820007978 Domain of unknown function (DUF4311); Region: DUF4311; cl11919 998820007979 Domain of unknown function (DUF4312); Region: DUF4312; cl11917 998820007980 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 998820007981 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 998820007982 HTH domain; Region: HTH_11; pfam08279 998820007983 HTH domain; Region: HTH_11; pfam08279 998820007984 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 998820007985 active site 998820007986 P-loop; other site 998820007987 phosphorylation site [posttranslational modification] 998820007988 Class I aldolases; Region: Aldolase_Class_I; cl17187 998820007989 catalytic residue [active] 998820007990 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 998820007991 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 998820007992 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 998820007993 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 998820007994 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 998820007995 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 998820007996 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 998820007997 HTH domain; Region: HTH_11; pfam08279 998820007998 PRD domain; Region: PRD; pfam00874 998820007999 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 998820008000 active site 998820008001 phosphorylation site [posttranslational modification] 998820008002 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 998820008003 classical (c) SDRs; Region: SDR_c; cd05233 998820008004 NAD(P) binding site [chemical binding]; other site 998820008005 active site 998820008006 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 998820008007 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 998820008008 intersubunit interface [polypeptide binding]; other site 998820008009 active site 998820008010 Zn2+ binding site [ion binding]; other site 998820008011 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820008012 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 998820008013 active site 998820008014 motif I; other site 998820008015 motif II; other site 998820008016 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820008017 motif II; other site 998820008018 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 998820008019 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 998820008020 AP (apurinic/apyrimidinic) site pocket; other site 998820008021 DNA interaction; other site 998820008022 Metal-binding active site; metal-binding site 998820008023 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 998820008024 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 998820008025 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 998820008026 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 998820008027 active site 998820008028 dimer interface [polypeptide binding]; other site 998820008029 magnesium binding site [ion binding]; other site 998820008030 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 998820008031 active site 998820008032 P-loop; other site 998820008033 phosphorylation site [posttranslational modification] 998820008034 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 998820008035 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 998820008036 active site 998820008037 phosphorylation site [posttranslational modification] 998820008038 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 998820008039 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 998820008040 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 998820008041 tetramer (dimer of dimers) interface [polypeptide binding]; other site 998820008042 active site 998820008043 dimer interface [polypeptide binding]; other site 998820008044 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 998820008045 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 998820008046 NAD(P) binding site [chemical binding]; other site 998820008047 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 998820008048 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 998820008049 substrate binding site [chemical binding]; other site 998820008050 hexamer interface [polypeptide binding]; other site 998820008051 metal binding site [ion binding]; metal-binding site 998820008052 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 998820008053 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 998820008054 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 998820008055 active site 998820008056 phosphorylation site [posttranslational modification] 998820008057 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 998820008058 active pocket/dimerization site; other site 998820008059 active site 998820008060 phosphorylation site [posttranslational modification] 998820008061 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 998820008062 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 998820008063 NAD(P) binding site [chemical binding]; other site 998820008064 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 998820008065 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 998820008066 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 998820008067 putative phosphoketolase; Provisional; Region: PRK05261 998820008068 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 998820008069 TPP-binding site; other site 998820008070 XFP C-terminal domain; Region: XFP_C; pfam09363 998820008071 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 998820008072 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 998820008073 nucleotide binding site [chemical binding]; other site 998820008074 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 998820008075 active site 998820008076 dimer interface [polypeptide binding]; other site 998820008077 catalytic nucleophile [active] 998820008078 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 998820008079 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 998820008080 active site 998820008081 metal binding site [ion binding]; metal-binding site 998820008082 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 998820008083 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 998820008084 DNA-binding site [nucleotide binding]; DNA binding site 998820008085 UTRA domain; Region: UTRA; pfam07702 998820008086 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 998820008087 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 998820008088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 998820008089 homodimer interface [polypeptide binding]; other site 998820008090 catalytic residue [active] 998820008091 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 998820008092 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 998820008093 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 998820008094 active site 998820008095 phosphorylation site [posttranslational modification] 998820008096 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 998820008097 active pocket/dimerization site; other site 998820008098 active site 998820008099 phosphorylation site [posttranslational modification] 998820008100 PRD domain; Region: PRD; pfam00874 998820008101 PRD domain; Region: PRD; pfam00874 998820008102 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 998820008103 active site 998820008104 P-loop; other site 998820008105 phosphorylation site [posttranslational modification] 998820008106 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 998820008107 active site 998820008108 phosphorylation site [posttranslational modification] 998820008109 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 998820008110 Helix-turn-helix domain; Region: HTH_38; pfam13936 998820008111 Integrase core domain; Region: rve; pfam00665 998820008112 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 998820008113 intersubunit interface [polypeptide binding]; other site 998820008114 active site 998820008115 zinc binding site [ion binding]; other site 998820008116 Na+ binding site [ion binding]; other site 998820008117 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 998820008118 putative N- and C-terminal domain interface [polypeptide binding]; other site 998820008119 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 998820008120 putative active site [active] 998820008121 putative MgATP binding site [chemical binding]; other site 998820008122 catalytic site [active] 998820008123 metal binding site [ion binding]; metal-binding site 998820008124 putative carbohydrate binding site [chemical binding]; other site 998820008125 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 998820008126 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 998820008127 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 998820008128 active site 998820008129 P-loop; other site 998820008130 phosphorylation site [posttranslational modification] 998820008131 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 998820008132 active site 998820008133 phosphorylation site [posttranslational modification] 998820008134 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 998820008135 intersubunit interface [polypeptide binding]; other site 998820008136 active site 998820008137 zinc binding site [ion binding]; other site 998820008138 Na+ binding site [ion binding]; other site 998820008139 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 998820008140 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 998820008141 DNA-binding site [nucleotide binding]; DNA binding site 998820008142 UTRA domain; Region: UTRA; pfam07702 998820008143 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 998820008144 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 998820008145 Coenzyme A binding pocket [chemical binding]; other site 998820008146 Predicted transcriptional regulators [Transcription]; Region: COG1695 998820008147 Transcriptional regulator PadR-like family; Region: PadR; cl17335 998820008148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820008149 D-galactonate transporter; Region: 2A0114; TIGR00893 998820008150 putative substrate translocation pore; other site 998820008151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820008152 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 998820008153 Coenzyme A binding pocket [chemical binding]; other site 998820008154 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 998820008155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820008156 dimer interface [polypeptide binding]; other site 998820008157 conserved gate region; other site 998820008158 putative PBP binding loops; other site 998820008159 ABC-ATPase subunit interface; other site 998820008160 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 998820008161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820008162 dimer interface [polypeptide binding]; other site 998820008163 conserved gate region; other site 998820008164 putative PBP binding loops; other site 998820008165 ABC-ATPase subunit interface; other site 998820008166 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 998820008167 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 998820008168 Walker A/P-loop; other site 998820008169 ATP binding site [chemical binding]; other site 998820008170 Q-loop/lid; other site 998820008171 ABC transporter signature motif; other site 998820008172 Walker B; other site 998820008173 D-loop; other site 998820008174 H-loop/switch region; other site 998820008175 TOBE domain; Region: TOBE_2; pfam08402 998820008176 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 998820008177 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 998820008178 active site 998820008179 Isochorismatase family; Region: Isochorismatase; pfam00857 998820008180 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 998820008181 catalytic triad [active] 998820008182 conserved cis-peptide bond; other site 998820008183 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 998820008184 nudix motif; other site 998820008185 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 998820008186 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 998820008187 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 998820008188 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 998820008189 active site 998820008190 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 998820008191 Beta-lactamase; Region: Beta-lactamase; pfam00144 998820008192 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 998820008193 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 998820008194 putative active site [active] 998820008195 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 998820008196 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 998820008197 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 998820008198 putative active site [active] 998820008199 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 998820008200 active site 998820008201 phosphorylation site [posttranslational modification] 998820008202 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 998820008203 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 998820008204 putative phosphate binding site [ion binding]; other site 998820008205 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 998820008206 DHH family; Region: DHH; pfam01368 998820008207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 998820008208 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 998820008209 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 998820008210 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 998820008211 Coenzyme A binding pocket [chemical binding]; other site 998820008212 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 998820008213 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 998820008214 Coenzyme A binding pocket [chemical binding]; other site 998820008215 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 998820008216 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820008217 active site 998820008218 motif I; other site 998820008219 motif II; other site 998820008220 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 998820008221 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 998820008222 putative NAD(P) binding site [chemical binding]; other site 998820008223 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 998820008224 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 998820008225 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 998820008226 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 998820008227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 998820008228 Coenzyme A binding pocket [chemical binding]; other site 998820008229 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 998820008230 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 998820008231 Coenzyme A binding pocket [chemical binding]; other site 998820008232 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 998820008233 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 998820008234 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 998820008235 Coenzyme A binding pocket [chemical binding]; other site 998820008236 Divergent AAA domain; Region: AAA_4; pfam04326 998820008237 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 998820008238 Integrase core domain; Region: rve; pfam00665 998820008239 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 998820008240 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 998820008241 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 998820008242 transmembrane helices; other site 998820008243 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 998820008244 hypothetical protein; Provisional; Region: PRK06446 998820008245 metal binding site [ion binding]; metal-binding site 998820008246 dimer interface [polypeptide binding]; other site 998820008247 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 998820008248 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 998820008249 peptide binding site [polypeptide binding]; other site 998820008250 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 998820008251 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 998820008252 Soluble P-type ATPase [General function prediction only]; Region: COG4087 998820008253 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 998820008254 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 998820008255 putative dimer interface [polypeptide binding]; other site 998820008256 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 998820008257 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 998820008258 protein binding site [polypeptide binding]; other site 998820008259 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 998820008260 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 998820008261 YycH protein; Region: YycI; pfam09648 998820008262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 998820008263 YycH protein; Region: YycH; pfam07435 998820008264 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 998820008265 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 998820008266 dimerization interface [polypeptide binding]; other site 998820008267 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 998820008268 putative active site [active] 998820008269 heme pocket [chemical binding]; other site 998820008270 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 998820008271 dimer interface [polypeptide binding]; other site 998820008272 phosphorylation site [posttranslational modification] 998820008273 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 998820008274 ATP binding site [chemical binding]; other site 998820008275 Mg2+ binding site [ion binding]; other site 998820008276 G-X-G motif; other site 998820008277 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 998820008278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 998820008279 active site 998820008280 phosphorylation site [posttranslational modification] 998820008281 intermolecular recognition site; other site 998820008282 dimerization interface [polypeptide binding]; other site 998820008283 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 998820008284 DNA binding site [nucleotide binding] 998820008285 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 998820008286 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 998820008287 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 998820008288 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 998820008289 substrate binding pocket [chemical binding]; other site 998820008290 membrane-bound complex binding site; other site 998820008291 hinge residues; other site 998820008292 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 998820008293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820008294 dimer interface [polypeptide binding]; other site 998820008295 conserved gate region; other site 998820008296 putative PBP binding loops; other site 998820008297 ABC-ATPase subunit interface; other site 998820008298 argininosuccinate synthase; Provisional; Region: PRK13820 998820008299 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 998820008300 ANP binding site [chemical binding]; other site 998820008301 Substrate Binding Site II [chemical binding]; other site 998820008302 Substrate Binding Site I [chemical binding]; other site 998820008303 argininosuccinate lyase; Provisional; Region: PRK00855 998820008304 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 998820008305 active sites [active] 998820008306 tetramer interface [polypeptide binding]; other site 998820008307 Uncharacterized conserved protein [Function unknown]; Region: COG3589 998820008308 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 998820008309 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 998820008310 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 998820008311 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 998820008312 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 998820008313 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 998820008314 DNA-binding site [nucleotide binding]; DNA binding site 998820008315 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 998820008316 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 998820008317 active site 998820008318 P-loop; other site 998820008319 phosphorylation site [posttranslational modification] 998820008320 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 998820008321 active site 998820008322 methionine cluster; other site 998820008323 phosphorylation site [posttranslational modification] 998820008324 metal binding site [ion binding]; metal-binding site 998820008325 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 998820008326 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 998820008327 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 998820008328 nudix motif; other site 998820008329 hypothetical protein; Provisional; Region: PRK06762 998820008330 AAA domain; Region: AAA_33; pfam13671 998820008331 Isochorismatase family; Region: Isochorismatase; pfam00857 998820008332 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 998820008333 catalytic triad [active] 998820008334 dimer interface [polypeptide binding]; other site 998820008335 conserved cis-peptide bond; other site 998820008336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820008337 Major Facilitator Superfamily; Region: MFS_1; pfam07690 998820008338 putative substrate translocation pore; other site 998820008339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820008340 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 998820008341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820008342 putative substrate translocation pore; other site 998820008343 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 998820008344 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 998820008345 active site 998820008346 catalytic tetrad [active] 998820008347 Domain of unknown function (DUF956); Region: DUF956; pfam06115 998820008348 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 998820008349 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 998820008350 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 998820008351 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 998820008352 active pocket/dimerization site; other site 998820008353 active site 998820008354 phosphorylation site [posttranslational modification] 998820008355 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 998820008356 active site 998820008357 phosphorylation site [posttranslational modification] 998820008358 H+ Antiporter protein; Region: 2A0121; TIGR00900 998820008359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 998820008360 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 998820008361 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 998820008362 non-specific DNA binding site [nucleotide binding]; other site 998820008363 salt bridge; other site 998820008364 sequence-specific DNA binding site [nucleotide binding]; other site 998820008365 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 998820008366 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 998820008367 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 998820008368 non-specific DNA binding site [nucleotide binding]; other site 998820008369 salt bridge; other site 998820008370 sequence-specific DNA binding site [nucleotide binding]; other site 998820008371 Helix-turn-helix domain; Region: HTH_19; pfam12844 998820008372 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 998820008373 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 998820008374 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 998820008375 substrate binding pocket [chemical binding]; other site 998820008376 membrane-bound complex binding site; other site 998820008377 hinge residues; other site 998820008378 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 998820008379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820008380 dimer interface [polypeptide binding]; other site 998820008381 conserved gate region; other site 998820008382 putative PBP binding loops; other site 998820008383 ABC-ATPase subunit interface; other site 998820008384 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 998820008385 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 998820008386 Walker A/P-loop; other site 998820008387 ATP binding site [chemical binding]; other site 998820008388 Q-loop/lid; other site 998820008389 ABC transporter signature motif; other site 998820008390 Walker B; other site 998820008391 D-loop; other site 998820008392 H-loop/switch region; other site 998820008393 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 998820008394 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 998820008395 Protein of unknown function (DUF975); Region: DUF975; cl10504 998820008396 Uncharacterized conserved protein [Function unknown]; Region: COG3402 998820008397 Predicted membrane protein [Function unknown]; Region: COG3428 998820008398 Bacterial PH domain; Region: DUF304; pfam03703 998820008399 Bacterial PH domain; Region: DUF304; pfam03703 998820008400 Bacterial PH domain; Region: DUF304; cl01348 998820008401 Predicted ATPase [General function prediction only]; Region: COG3910 998820008402 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 998820008403 Walker A/P-loop; other site 998820008404 ATP binding site [chemical binding]; other site 998820008405 Q-loop/lid; other site 998820008406 ABC transporter signature motif; other site 998820008407 Walker B; other site 998820008408 D-loop; other site 998820008409 H-loop/switch region; other site 998820008410 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 998820008411 Phosphotransferase enzyme family; Region: APH; pfam01636 998820008412 active site 998820008413 ATP binding site [chemical binding]; other site 998820008414 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 998820008415 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 998820008416 Walker A/P-loop; other site 998820008417 ATP binding site [chemical binding]; other site 998820008418 Q-loop/lid; other site 998820008419 ABC transporter signature motif; other site 998820008420 Walker B; other site 998820008421 D-loop; other site 998820008422 H-loop/switch region; other site 998820008423 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 998820008424 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 998820008425 substrate binding pocket [chemical binding]; other site 998820008426 membrane-bound complex binding site; other site 998820008427 hinge residues; other site 998820008428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820008429 dimer interface [polypeptide binding]; other site 998820008430 conserved gate region; other site 998820008431 putative PBP binding loops; other site 998820008432 ABC-ATPase subunit interface; other site 998820008433 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 998820008434 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 998820008435 substrate binding pocket [chemical binding]; other site 998820008436 membrane-bound complex binding site; other site 998820008437 hinge residues; other site 998820008438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 998820008439 dimer interface [polypeptide binding]; other site 998820008440 conserved gate region; other site 998820008441 putative PBP binding loops; other site 998820008442 ABC-ATPase subunit interface; other site 998820008443 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 998820008444 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 998820008445 Integral membrane protein DUF95; Region: DUF95; pfam01944 998820008446 MoxR-like ATPases [General function prediction only]; Region: COG0714 998820008447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 998820008448 Walker A motif; other site 998820008449 ATP binding site [chemical binding]; other site 998820008450 Walker B motif; other site 998820008451 MoxR-like ATPases [General function prediction only]; Region: COG0714 998820008452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 998820008453 Protein of unknown function DUF58; Region: DUF58; pfam01882 998820008454 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 998820008455 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 998820008456 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 998820008457 putative ADP-binding pocket [chemical binding]; other site 998820008458 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 998820008459 maltose O-acetyltransferase; Provisional; Region: PRK10092 998820008460 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 998820008461 active site 998820008462 substrate binding site [chemical binding]; other site 998820008463 trimer interface [polypeptide binding]; other site 998820008464 CoA binding site [chemical binding]; other site 998820008465 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820008466 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 998820008467 active site 998820008468 motif I; other site 998820008469 motif II; other site 998820008470 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820008471 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 998820008472 Aspartase; Region: Aspartase; cd01357 998820008473 active sites [active] 998820008474 tetramer interface [polypeptide binding]; other site 998820008475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 998820008476 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 998820008477 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 998820008478 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 998820008479 Malic enzyme, N-terminal domain; Region: malic; pfam00390 998820008480 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 998820008481 putative NAD(P) binding site [chemical binding]; other site 998820008482 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 998820008483 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 998820008484 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 998820008485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 998820008486 active site 998820008487 phosphorylation site [posttranslational modification] 998820008488 intermolecular recognition site; other site 998820008489 dimerization interface [polypeptide binding]; other site 998820008490 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 998820008491 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 998820008492 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 998820008493 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 998820008494 Agrin NtA domain; Region: NtA; pfam03146 998820008495 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 998820008496 Int/Topo IB signature motif; other site 998820008497 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 998820008498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 998820008499 non-specific DNA binding site [nucleotide binding]; other site 998820008500 salt bridge; other site 998820008501 sequence-specific DNA binding site [nucleotide binding]; other site 998820008502 Helix-turn-helix domain; Region: HTH_17; pfam12728 998820008503 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 998820008504 polymerase nucleotide-binding site; other site 998820008505 DNA-binding residues [nucleotide binding]; DNA binding site 998820008506 nucleotide binding site [chemical binding]; other site 998820008507 primase nucleotide-binding site [nucleotide binding]; other site 998820008508 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 998820008509 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 998820008510 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 998820008511 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 998820008512 active site 998820008513 Phage terminase, small subunit; Region: Terminase_4; pfam05119 998820008514 Phage Terminase; Region: Terminase_1; pfam03354 998820008515 Phage portal protein; Region: Phage_portal; pfam04860 998820008516 Phage-related protein [Function unknown]; Region: COG4695; cl01923 998820008517 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 998820008518 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 998820008519 Phage capsid family; Region: Phage_capsid; pfam05065 998820008520 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 998820008521 oligomerization interface [polypeptide binding]; other site 998820008522 Predicted membrane protein [Function unknown]; Region: COG2261 998820008523 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 998820008524 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 998820008525 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 998820008526 active site 998820008527 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 998820008528 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 998820008529 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 998820008530 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 998820008531 substrate binding pocket [chemical binding]; other site 998820008532 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 998820008533 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 998820008534 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 998820008535 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 998820008536 active site 998820008537 phosphorylation site [posttranslational modification] 998820008538 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 998820008539 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 998820008540 Mga helix-turn-helix domain; Region: Mga; pfam05043 998820008541 DNA-binding interface [nucleotide binding]; DNA binding site 998820008542 PRD domain; Region: PRD; pfam00874 998820008543 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 998820008544 active site 998820008545 P-loop; other site 998820008546 phosphorylation site [posttranslational modification] 998820008547 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 998820008548 active site 998820008549 phosphorylation site [posttranslational modification] 998820008550 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 998820008551 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 998820008552 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 998820008553 active site 998820008554 P-loop; other site 998820008555 phosphorylation site [posttranslational modification] 998820008556 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 998820008557 active site 998820008558 P-loop; other site 998820008559 phosphorylation site [posttranslational modification] 998820008560 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 998820008561 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 998820008562 active site 998820008563 trimer interface [polypeptide binding]; other site 998820008564 allosteric site; other site 998820008565 active site lid [active] 998820008566 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 998820008567 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 998820008568 active site 998820008569 motif I; other site 998820008570 motif II; other site 998820008571 HlyD family secretion protein; Region: HlyD_2; pfam12700 998820008572 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 998820008573 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 998820008574 Walker A/P-loop; other site 998820008575 ATP binding site [chemical binding]; other site 998820008576 Q-loop/lid; other site 998820008577 ABC transporter signature motif; other site 998820008578 Walker B; other site 998820008579 D-loop; other site 998820008580 H-loop/switch region; other site 998820008581 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 998820008582 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 998820008583 FtsX-like permease family; Region: FtsX; pfam02687 998820008584 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 998820008585 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 998820008586 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 998820008587 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 998820008588 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 998820008589 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 998820008590 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 998820008591 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 998820008592 putative active site [active] 998820008593 metal binding site [ion binding]; metal-binding site 998820008594 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 998820008595 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 998820008596 metal binding site [ion binding]; metal-binding site 998820008597 dimer interface [polypeptide binding]; other site 998820008598 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 998820008599 Uncharacterized conserved protein [Function unknown]; Region: COG2966 998820008600 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 998820008601 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 998820008602 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 998820008603 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 998820008604 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 998820008605 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 998820008606 trmE is a tRNA modification GTPase; Region: trmE; cd04164 998820008607 G1 box; other site 998820008608 GTP/Mg2+ binding site [chemical binding]; other site 998820008609 Switch I region; other site 998820008610 G2 box; other site 998820008611 Switch II region; other site 998820008612 G3 box; other site 998820008613 G4 box; other site 998820008614 G5 box; other site 998820008615 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 998820008616 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 998820008617 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 998820008618 G-X-X-G motif; other site 998820008619 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 998820008620 RxxxH motif; other site 998820008621 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 998820008622 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 998820008623 ribonuclease P; Reviewed; Region: rnpA; PRK00499 998820008624 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 998820008625 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 998820008626 Toprim-like; Region: Toprim_2; pfam13155 998820008627 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 998820008628 Domain of unknown function (DUF955); Region: DUF955; cl01076 998820008629 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 998820008630 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 998820008631 Peptidase family M23; Region: Peptidase_M23; pfam01551 998820008632 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 998820008633 Surface antigen [General function prediction only]; Region: COG3942 998820008634 CHAP domain; Region: CHAP; pfam05257 998820008635 AAA-like domain; Region: AAA_10; pfam12846 998820008636 Domain of unknown function DUF87; Region: DUF87; pfam01935 998820008637 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 998820008638 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 998820008639 Walker A motif; other site 998820008640 ATP binding site [chemical binding]; other site 998820008641 Walker B motif; other site 998820008642 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 998820008643 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 998820008644 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 998820008645 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 998820008646 Integrase core domain; Region: rve; pfam00665 998820008647 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 998820008648 AIR carboxylase; Region: AIRC; smart01001 998820008649 Protein of unknown function DUF111; Region: DUF111; cl03398 998820008650 Protein of unknown function DUF111; Region: DUF111; cl03398 998820008651 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 998820008652 amphipathic channel; other site 998820008653 Asn-Pro-Ala signature motifs; other site 998820008654 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 998820008655 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 998820008656 Ligand Binding Site [chemical binding]; other site 998820008657 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 998820008658 Integrase core domain; Region: rve; pfam00665 998820008659 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 998820008660 Pleckstrin homology-like domain; Region: PH-like; cl17171 998820008661 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 998820008662 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 998820008663 HsdM N-terminal domain; Region: HsdM_N; pfam12161 998820008664 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 998820008665 Methyltransferase domain; Region: Methyltransf_26; pfam13659 998820008666 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 998820008667 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 998820008668 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 998820008669 ATP binding site [chemical binding]; other site 998820008670 putative Mg++ binding site [ion binding]; other site 998820008671 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 998820008672 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 998820008673 dimer interface [polypeptide binding]; other site 998820008674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 998820008675 catalytic residue [active] 998820008676 cystathionine beta-lyase; Provisional; Region: PRK07671 998820008677 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 998820008678 homodimer interface [polypeptide binding]; other site 998820008679 substrate-cofactor binding pocket; other site 998820008680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 998820008681 catalytic residue [active] 998820008682 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 998820008683 trimer interface [polypeptide binding]; other site 998820008684 active site 998820008685 substrate binding site [chemical binding]; other site 998820008686 CoA binding site [chemical binding]; other site 998820008687 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 998820008688 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 998820008689 Dimer interface [polypeptide binding]; other site 998820008690 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 998820008691 multiple promoter invertase; Provisional; Region: mpi; PRK13413 998820008692 catalytic residues [active] 998820008693 catalytic nucleophile [active] 998820008694 Presynaptic Site I dimer interface [polypeptide binding]; other site 998820008695 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 998820008696 Synaptic Flat tetramer interface [polypeptide binding]; other site 998820008697 Synaptic Site I dimer interface [polypeptide binding]; other site 998820008698 DNA binding site [nucleotide binding] 998820008699 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 998820008700 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 998820008701 HTH-like domain; Region: HTH_21; pfam13276 998820008702 Integrase core domain; Region: rve; pfam00665 998820008703 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 998820008704 Transposase; Region: HTH_Tnp_1; pfam01527 998820008705 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 998820008706 Collagen binding domain; Region: Collagen_bind; pfam05737 998820008707 Collagen binding domain; Region: Collagen_bind; pfam05737 998820008708 Collagen binding domain; Region: Collagen_bind; pfam05737 998820008709 Collagen binding domain; Region: Collagen_bind; pfam05737 998820008710 Cna protein B-type domain; Region: Cna_B; pfam05738 998820008711 Cna protein B-type domain; Region: Cna_B; pfam05738 998820008712 Cna protein B-type domain; Region: Cna_B; pfam05738 998820008713 Cna protein B-type domain; Region: Cna_B; pfam05738 998820008714 Cna protein B-type domain; Region: Cna_B; pfam05738 998820008715 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 998820008716 Transposase; Region: HTH_Tnp_1; pfam01527 998820008717 putative transposase OrfB; Reviewed; Region: PHA02517 998820008718 HTH-like domain; Region: HTH_21; pfam13276 998820008719 Integrase core domain; Region: rve; pfam00665 998820008720 Integrase core domain; Region: rve_3; pfam13683 998820008721 DNA polymerase IV; Reviewed; Region: PRK03103 998820008722 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 998820008723 active site 998820008724 DNA binding site [nucleotide binding] 998820008725 AAA domain; Region: AAA_31; pfam13614 998820008726 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 998820008727 P-loop; other site 998820008728 Magnesium ion binding site [ion binding]; other site 998820008729 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 998820008730 Magnesium ion binding site [ion binding]; other site 998820008731 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 998820008732 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 998820008733 Integrase core domain; Region: rve; pfam00665