-- dump date   	20140619_122826
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
543734000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
543734000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
543734000003	Walker A motif; other site
543734000004	ATP binding site [chemical binding]; other site
543734000005	Walker B motif; other site
543734000006	arginine finger; other site
543734000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
543734000008	DnaA box-binding interface [nucleotide binding]; other site
543734000009	DNA polymerase III subunit beta; Validated; Region: PRK05643
543734000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
543734000011	putative DNA binding surface [nucleotide binding]; other site
543734000012	dimer interface [polypeptide binding]; other site
543734000013	beta-clamp/clamp loader binding surface; other site
543734000014	beta-clamp/translesion DNA polymerase binding surface; other site
543734000015	S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501
543734000016	recombination protein F; Reviewed; Region: recF; PRK00064
543734000017	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
543734000018	Walker A/P-loop; other site
543734000019	ATP binding site [chemical binding]; other site
543734000020	Q-loop/lid; other site
543734000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734000022	ABC transporter signature motif; other site
543734000023	Walker B; other site
543734000024	D-loop; other site
543734000025	H-loop/switch region; other site
543734000026	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
543734000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
543734000028	Mg2+ binding site [ion binding]; other site
543734000029	G-X-G motif; other site
543734000030	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
543734000031	anchoring element; other site
543734000032	dimer interface [polypeptide binding]; other site
543734000033	ATP binding site [chemical binding]; other site
543734000034	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
543734000035	active site
543734000036	metal binding site [ion binding]; metal-binding site
543734000037	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
543734000038	DNA gyrase subunit A; Validated; Region: PRK05560
543734000039	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
543734000040	CAP-like domain; other site
543734000041	active site
543734000042	primary dimer interface [polypeptide binding]; other site
543734000043	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
543734000044	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
543734000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
543734000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
543734000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
543734000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
543734000049	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
543734000050	intersubunit interface [polypeptide binding]; other site
543734000051	active site
543734000052	catalytic residue [active]
543734000053	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
543734000054	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
543734000055	dimer interface [polypeptide binding]; other site
543734000056	ssDNA binding site [nucleotide binding]; other site
543734000057	tetramer (dimer of dimers) interface [polypeptide binding]; other site
543734000058	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
543734000059	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
543734000060	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
543734000061	dimer interface [polypeptide binding]; other site
543734000062	ssDNA binding site [nucleotide binding]; other site
543734000063	tetramer (dimer of dimers) interface [polypeptide binding]; other site
543734000064	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
543734000065	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
543734000066	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
543734000067	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
543734000068	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
543734000069	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
543734000070	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
543734000071	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
543734000072	CAAX protease self-immunity; Region: Abi; pfam02517
543734000073	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
543734000074	Surface antigen [General function prediction only]; Region: COG3942
543734000075	CHAP domain; Region: CHAP; pfam05257
543734000076	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
543734000077	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
543734000078	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
543734000079	FtsX-like permease family; Region: FtsX; pfam02687
543734000080	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
543734000081	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
543734000082	Walker A/P-loop; other site
543734000083	ATP binding site [chemical binding]; other site
543734000084	Q-loop/lid; other site
543734000085	ABC transporter signature motif; other site
543734000086	Walker B; other site
543734000087	D-loop; other site
543734000088	H-loop/switch region; other site
543734000089	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
543734000090	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
543734000091	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734000092	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
543734000093	active site
543734000094	motif I; other site
543734000095	motif II; other site
543734000096	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
543734000097	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
543734000098	BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418
543734000099	active site
543734000100	hypothetical protein; Provisional; Region: PRK10621
543734000101	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
543734000102	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
543734000103	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
543734000104	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
543734000105	Cl binding site [ion binding]; other site
543734000106	oligomer interface [polypeptide binding]; other site
543734000107	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
543734000108	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
543734000109	hypothetical protein
543734000110	manganese transport protein MntH; Reviewed; Region: PRK00701
543734000111	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
543734000112	Peptidase family C69; Region: Peptidase_C69; pfam03577
543734000113	Enterocin A Immunity; Region: EntA_Immun; pfam08951
543734000114	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
543734000115	Predicted membrane protein [Function unknown]; Region: COG4392
543734000116	CAAX protease self-immunity; Region: Abi; pfam02517
543734000117	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
543734000118	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
543734000119	active site
543734000120	intersubunit interface [polypeptide binding]; other site
543734000121	catalytic residue [active]
543734000122	Transposase domain (DUF772); Region: DUF772; pfam05598
543734000123	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
543734000124	Transcriptional regulators [Transcription]; Region: GntR; COG1802
543734000125	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
543734000126	DNA-binding site [nucleotide binding]; DNA binding site
543734000127	FCD domain; Region: FCD; pfam07729
543734000128	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
543734000129	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734000130	non-specific DNA binding site [nucleotide binding]; other site
543734000131	salt bridge; other site
543734000132	sequence-specific DNA binding site [nucleotide binding]; other site
543734000133	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
543734000134	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
543734000135	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
543734000136	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
543734000137	Walker A/P-loop; other site
543734000138	ATP binding site [chemical binding]; other site
543734000139	Q-loop/lid; other site
543734000140	ABC transporter signature motif; other site
543734000141	Walker B; other site
543734000142	D-loop; other site
543734000143	H-loop/switch region; other site
543734000144	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734000145	Major Facilitator Superfamily; Region: MFS_1; pfam07690
543734000146	putative substrate translocation pore; other site
543734000147	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734000148	Predicted membrane protein [General function prediction only]; Region: COG4194
543734000149	MMPL family; Region: MMPL; pfam03176
543734000150	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
543734000151	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
543734000152	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
543734000153	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734000154	putative PBP binding loops; other site
543734000155	dimer interface [polypeptide binding]; other site
543734000156	ABC-ATPase subunit interface; other site
543734000157	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
543734000158	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734000159	dimer interface [polypeptide binding]; other site
543734000160	conserved gate region; other site
543734000161	putative PBP binding loops; other site
543734000162	ABC-ATPase subunit interface; other site
543734000163	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
543734000164	glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186
543734000165	Walker A/P-loop; other site
543734000166	ATP binding site [chemical binding]; other site
543734000167	Q-loop/lid; other site
543734000168	ABC transporter signature motif; other site
543734000169	Walker B; other site
543734000170	D-loop; other site
543734000171	H-loop/switch region; other site
543734000172	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
543734000173	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
543734000174	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
543734000175	Soluble P-type ATPase [General function prediction only]; Region: COG4087
543734000176	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
543734000177	metal-binding site [ion binding]
543734000178	hypothetical protein
543734000179	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
543734000180	dinuclear metal binding motif [ion binding]; other site
543734000181	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
543734000182	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
543734000183	ligand binding site [chemical binding]; other site
543734000184	flexible hinge region; other site
543734000185	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
543734000186	putative switch regulator; other site
543734000187	non-specific DNA interactions [nucleotide binding]; other site
543734000188	DNA binding site [nucleotide binding]
543734000189	sequence specific DNA binding site [nucleotide binding]; other site
543734000190	putative cAMP binding site [chemical binding]; other site
543734000191	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
543734000192	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
543734000193	substrate binding site [chemical binding]; other site
543734000194	active site
543734000195	catalytic residues [active]
543734000196	heterodimer interface [polypeptide binding]; other site
543734000197	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
543734000198	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
543734000199	pyridoxal 5'-phosphate binding site [chemical binding]; other site
543734000200	catalytic residue [active]
543734000201	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
543734000202	active site
543734000203	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
543734000204	active site
543734000205	ribulose/triose binding site [chemical binding]; other site
543734000206	phosphate binding site [ion binding]; other site
543734000207	substrate (anthranilate) binding pocket [chemical binding]; other site
543734000208	product (indole) binding pocket [chemical binding]; other site
543734000209	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
543734000210	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
543734000211	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
543734000212	hypothetical protein
543734000213	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
543734000214	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
543734000215	active site
543734000216	P-loop; other site
543734000217	phosphorylation site [posttranslational modification]
543734000218	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
543734000219	active site
543734000220	phosphorylation site [posttranslational modification]
543734000221	hypothetical protein
543734000222	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734000223	Major Facilitator Superfamily; Region: MFS_1; pfam07690
543734000224	putative substrate translocation pore; other site
543734000225	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734000226	putative substrate translocation pore; other site
543734000227	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
543734000228	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
543734000229	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
543734000230	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
543734000231	Walker A/P-loop; other site
543734000232	ATP binding site [chemical binding]; other site
543734000233	Q-loop/lid; other site
543734000234	ABC transporter signature motif; other site
543734000235	Walker B; other site
543734000236	D-loop; other site
543734000237	H-loop/switch region; other site
543734000238	PemK-like protein; Region: PemK; pfam02452
543734000239	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
543734000240	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
543734000241	BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418
543734000242	active site
543734000243	hypothetical protein
543734000244	dihydrodipicolinate reductase; Provisional; Region: PRK00048
543734000245	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
543734000246	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
543734000247	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
543734000248	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
543734000249	dimer interface [polypeptide binding]; other site
543734000250	active site
543734000251	catalytic residue [active]
543734000252	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
543734000253	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
543734000254	metal binding site [ion binding]; metal-binding site
543734000255	putative dimer interface [polypeptide binding]; other site
543734000256	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
543734000257	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
543734000258	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
543734000259	putative trimer interface [polypeptide binding]; other site
543734000260	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
543734000261	putative CoA binding site [chemical binding]; other site
543734000262	putative trimer interface [polypeptide binding]; other site
543734000263	putative CoA binding site [chemical binding]; other site
543734000264	diaminopimelate decarboxylase; Region: lysA; TIGR01048
543734000265	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
543734000266	active site
543734000267	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
543734000268	substrate binding site [chemical binding]; other site
543734000269	catalytic residues [active]
543734000270	dimer interface [polypeptide binding]; other site
543734000271	aspartate kinase; Reviewed; Region: PRK09034
543734000272	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
543734000273	putative catalytic residues [active]
543734000274	putative nucleotide binding site [chemical binding]; other site
543734000275	putative aspartate binding site [chemical binding]; other site
543734000276	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
543734000277	allosteric regulatory residue; other site
543734000278	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
543734000279	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
543734000280	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
543734000281	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
543734000282	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
543734000283	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
543734000284	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
543734000285	nudix motif; other site
543734000286	EamA-like transporter family; Region: EamA; cl17759
543734000287	PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417
543734000288	catalytic residues [active]
543734000289	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
543734000290	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
543734000291	DHH family; Region: DHH; pfam01368
543734000292	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
543734000293	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
543734000294	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
543734000295	replicative DNA helicase; Provisional; Region: PRK05748
543734000296	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
543734000297	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
543734000298	Walker A motif; other site
543734000299	ATP binding site [chemical binding]; other site
543734000300	Walker B motif; other site
543734000301	DNA binding loops [nucleotide binding]
543734000302	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
543734000303	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
543734000304	GDP-binding site [chemical binding]; other site
543734000305	ACT binding site; other site
543734000306	IMP binding site; other site
543734000307	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
543734000308	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
543734000309	Soluble P-type ATPase [General function prediction only]; Region: COG4087
543734000310	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
543734000311	dimerization interface [polypeptide binding]; other site
543734000312	putative DNA binding site [nucleotide binding]; other site
543734000313	putative Zn2+ binding site [ion binding]; other site
543734000314	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
543734000315	plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647
543734000316	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
543734000317	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
543734000318	Transcriptional regulator [Transcription]; Region: LysR; COG0583
543734000319	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
543734000320	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
543734000321	dimerization interface [polypeptide binding]; other site
543734000322	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
543734000323	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734000324	non-specific DNA binding site [nucleotide binding]; other site
543734000325	salt bridge; other site
543734000326	sequence-specific DNA binding site [nucleotide binding]; other site
543734000327	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
543734000328	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
543734000329	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
543734000330	Walker A/P-loop; other site
543734000331	ATP binding site [chemical binding]; other site
543734000332	Q-loop/lid; other site
543734000333	ABC transporter signature motif; other site
543734000334	Walker B; other site
543734000335	D-loop; other site
543734000336	H-loop/switch region; other site
543734000337	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
543734000338	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
543734000339	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
543734000340	ATP cone domain; Region: ATP-cone; pfam03477
543734000341	Class III ribonucleotide reductase; Region: RNR_III; cd01675
543734000342	effector binding site; other site
543734000343	active site
543734000344	Zn binding site [ion binding]; other site
543734000345	glycine loop; other site
543734000346	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
543734000347	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734000348	non-specific DNA binding site [nucleotide binding]; other site
543734000349	salt bridge; other site
543734000350	sequence-specific DNA binding site [nucleotide binding]; other site
543734000351	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
543734000352	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
543734000353	active site
543734000354	metal binding site [ion binding]; metal-binding site
543734000355	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
543734000356	FAD binding domain; Region: FAD_binding_4; pfam01565
543734000357	Transposase domain (DUF772); Region: DUF772; pfam05598
543734000358	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
543734000359	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
543734000360	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
543734000361	active site
543734000362	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
543734000363	putative dimer interface [polypeptide binding]; other site
543734000364	catalytic triad [active]
543734000365	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
543734000366	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
543734000367	ATP-grasp domain; Region: ATP-grasp_4; cl17255
543734000368	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
543734000369	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
543734000370	DNA binding site [nucleotide binding]
543734000371	active site
543734000372	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
543734000373	D-lactate dehydrogenase; Validated; Region: PRK08605
543734000374	homodimer interface [polypeptide binding]; other site
543734000375	ligand binding site [chemical binding]; other site
543734000376	NAD binding site [chemical binding]; other site
543734000377	catalytic site [active]
543734000378	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
543734000379	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
543734000380	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
543734000381	NAD(P) binding site [chemical binding]; other site
543734000382	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
543734000383	Protein of unknown function (DUF1516); Region: DUF1516; pfam07457
543734000384	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
543734000385	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
543734000386	Helix-turn-helix domain; Region: HTH_38; pfam13936
543734000387	Integrase core domain; Region: rve; pfam00665
543734000388	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
543734000389	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
543734000390	Zn binding site [ion binding]; other site
543734000391	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
543734000392	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
543734000393	WxL domain surface cell wall-binding; Region: WxL; pfam13731
543734000394	WxL domain surface cell wall-binding; Region: WxL; pfam13731
543734000395	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
543734000396	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
543734000397	Mga helix-turn-helix domain; Region: Mga; pfam05043
543734000398	Protein of unknown function (DUF805); Region: DUF805; pfam05656
543734000399	Protein of unknown function (DUF805); Region: DUF805; pfam05656
543734000400	recombination factor protein RarA; Reviewed; Region: PRK13342
543734000401	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
543734000402	Walker A motif; other site
543734000403	ATP binding site [chemical binding]; other site
543734000404	Walker B motif; other site
543734000405	arginine finger; other site
543734000406	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
543734000407	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
543734000408	propionate/acetate kinase; Provisional; Region: PRK12379
543734000409	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
543734000410	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
543734000411	active site
543734000412	metal binding site [ion binding]; metal-binding site
543734000413	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
543734000414	endonuclease III; Region: ENDO3c; smart00478
543734000415	minor groove reading motif; other site
543734000416	helix-hairpin-helix signature motif; other site
543734000417	substrate binding pocket [chemical binding]; other site
543734000418	active site
543734000419	Domain of unknown function DUF77; Region: DUF77; pfam01910
543734000420	Predicted membrane protein [Function unknown]; Region: COG1511
543734000421	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
543734000422	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
543734000423	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
543734000424	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
543734000425	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
543734000426	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
543734000427	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734000428	Major Facilitator Superfamily; Region: MFS_1; pfam07690
543734000429	putative substrate translocation pore; other site
543734000430	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734000431	putative phosphoketolase; Provisional; Region: PRK05261
543734000432	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
543734000433	TPP-binding site; other site
543734000434	XFP C-terminal domain; Region: XFP_C; pfam09363
543734000435	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
543734000436	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
543734000437	peptide binding site [polypeptide binding]; other site
543734000438	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
543734000439	nudix motif; other site
543734000440	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
543734000441	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
543734000442	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
543734000443	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
543734000444	Repair protein; Region: Repair_PSII; pfam04536
543734000445	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
543734000446	Protein of unknown function (DUF1634); Region: DUF1634; pfam07843
543734000447	RnfE family; Region: NQR2_RnfD_RnfE; cl00779
543734000448	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
543734000449	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
543734000450	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
543734000451	putative ligand binding site [chemical binding]; other site
543734000452	putative NAD binding site [chemical binding]; other site
543734000453	catalytic site [active]
543734000454	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
543734000455	Predicted membrane protein [Function unknown]; Region: COG2261
543734000456	Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031
543734000457	Asp23 family; Region: Asp23; pfam03780
543734000458	Asp23 family; Region: Asp23; pfam03780
543734000459	Protein of unknown function (DUF969); Region: DUF969; pfam06149
543734000460	Predicted membrane protein [Function unknown]; Region: COG3817
543734000461	Protein of unknown function (DUF979); Region: DUF979; pfam06166
543734000462	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
543734000463	putative substrate binding pocket [chemical binding]; other site
543734000464	AC domain interface; other site
543734000465	catalytic triad [active]
543734000466	AB domain interface; other site
543734000467	interchain disulfide; other site
543734000468	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
543734000469	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
543734000470	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
543734000471	catalytic triad [active]
543734000472	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
543734000473	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
543734000474	S-adenosylmethionine binding site [chemical binding]; other site
543734000475	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
543734000476	ParB-like nuclease domain; Region: ParBc; pfam02195
543734000477	KorB domain; Region: KorB; pfam08535
543734000478	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
543734000479	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
543734000480	P-loop; other site
543734000481	Magnesium ion binding site [ion binding]; other site
543734000482	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
543734000483	Magnesium ion binding site [ion binding]; other site
543734000484	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
543734000485	ParB-like nuclease domain; Region: ParB; smart00470
543734000486	KorB domain; Region: KorB; pfam08535
543734000487	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
543734000488	GTP-binding protein YchF; Reviewed; Region: PRK09601
543734000489	YchF GTPase; Region: YchF; cd01900
543734000490	G1 box; other site
543734000491	GTP/Mg2+ binding site [chemical binding]; other site
543734000492	Switch I region; other site
543734000493	G2 box; other site
543734000494	Switch II region; other site
543734000495	G3 box; other site
543734000496	G4 box; other site
543734000497	G5 box; other site
543734000498	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
543734000499	Protein of unknown function (DUF1129); Region: DUF1129; pfam06570
543734000500	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
543734000501	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
543734000502	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
543734000503	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
543734000504	active site
543734000505	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
543734000506	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
543734000507	active site
543734000508	phosphorylation site [posttranslational modification]
543734000509	intermolecular recognition site; other site
543734000510	dimerization interface [polypeptide binding]; other site
543734000511	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
543734000512	DNA binding site [nucleotide binding]
543734000513	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
543734000514	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
543734000515	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
543734000516	dimer interface [polypeptide binding]; other site
543734000517	phosphorylation site [posttranslational modification]
543734000518	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
543734000519	ATP binding site [chemical binding]; other site
543734000520	Mg2+ binding site [ion binding]; other site
543734000521	G-X-G motif; other site
543734000522	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
543734000523	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
543734000524	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
543734000525	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
543734000526	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
543734000527	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
543734000528	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
543734000529	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
543734000530	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
543734000531	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
543734000532	aspartate racemase; Region: asp_race; TIGR00035
543734000533	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
543734000534	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
543734000535	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
543734000536	active site
543734000537	catalytic tetrad [active]
543734000538	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
543734000539	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
543734000540	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
543734000541	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
543734000542	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734000543	putative substrate translocation pore; other site
543734000544	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734000545	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
543734000546	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
543734000547	tetrameric interface [polypeptide binding]; other site
543734000548	NAD binding site [chemical binding]; other site
543734000549	catalytic residues [active]
543734000550	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
543734000551	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
543734000552	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
543734000553	substrate binding site [chemical binding]; other site
543734000554	ATP binding site [chemical binding]; other site
543734000555	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
543734000556	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
543734000557	PYR/PP interface [polypeptide binding]; other site
543734000558	dimer interface [polypeptide binding]; other site
543734000559	TPP binding site [chemical binding]; other site
543734000560	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
543734000561	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
543734000562	TPP-binding site; other site
543734000563	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
543734000564	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
543734000565	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
543734000566	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
543734000567	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
543734000568	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
543734000569	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
543734000570	Fructose-bisphosphate aldolase class-II; Region: F_bP_aldolase; pfam01116
543734000571	active site
543734000572	intersubunit interface [polypeptide binding]; other site
543734000573	zinc binding site [ion binding]; other site
543734000574	Na+ binding site [ion binding]; other site
543734000575	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
543734000576	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
543734000577	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
543734000578	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
543734000579	putative active site [active]
543734000580	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
543734000581	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
543734000582	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
543734000583	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
543734000584	N- and C-terminal domain interface [polypeptide binding]; other site
543734000585	active site
543734000586	catalytic site [active]
543734000587	metal binding site [ion binding]; metal-binding site
543734000588	carbohydrate binding site [chemical binding]; other site
543734000589	ATP binding site [chemical binding]; other site
543734000590	fructuronate transporter; Provisional; Region: PRK10034; cl15264
543734000591	Citrate transporter; Region: CitMHS; pfam03600
543734000592	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
543734000593	active site
543734000594	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
543734000595	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
543734000596	Probable Catalytic site; other site
543734000597	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
543734000598	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
543734000599	active site
543734000600	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
543734000601	AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522
543734000602	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
543734000603	active site
543734000604	SH3-like domain; Region: SH3_8; pfam13457
543734000605	SH3-like domain; Region: SH3_8; pfam13457
543734000606	SH3-like domain; Region: SH3_8; pfam13457
543734000607	SH3-like domain; Region: SH3_8; pfam13457
543734000608	SH3-like domain; Region: SH3_8; pfam13457
543734000609	SH3-like domain; Region: SH3_8; pfam13457
543734000610	SH3-like domain; Region: SH3_8; pfam13457
543734000611	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
543734000612	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
543734000613	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
543734000614	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
543734000615	active site
543734000616	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
543734000617	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
543734000618	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
543734000619	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
543734000620	putative PBP binding regions; other site
543734000621	ABC-ATPase subunit  interface; other site
543734000622	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
543734000623	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
543734000624	active site
543734000625	metal binding site [ion binding]; metal-binding site
543734000626	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
543734000627	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
543734000628	oligoendopeptidase F; Region: pepF; TIGR00181
543734000629	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
543734000630	active site
543734000631	Zn binding site [ion binding]; other site
543734000632	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
543734000633	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
543734000634	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
543734000635	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
543734000636	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
543734000637	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
543734000638	active site
543734000639	Protein of unknown function (DUF975); Region: DUF975; cl10504
543734000640	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
543734000641	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
543734000642	Catalytic site [active]
543734000643	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
543734000644	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
543734000645	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
543734000646	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
543734000647	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
543734000648	ABC transporter; Region: ABC_tran_2; pfam12848
543734000649	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
543734000650	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
543734000651	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
543734000652	S-adenosylmethionine binding site [chemical binding]; other site
543734000653	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
543734000654	catalytic residues [active]
543734000655	Uncharacterized conserved protein [Function unknown]; Region: COG2966
543734000656	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
543734000657	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
543734000658	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
543734000659	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
543734000660	putative ligand binding site [chemical binding]; other site
543734000661	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
543734000662	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
543734000663	TM-ABC transporter signature motif; other site
543734000664	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
543734000665	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
543734000666	TM-ABC transporter signature motif; other site
543734000667	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
543734000668	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
543734000669	Walker A/P-loop; other site
543734000670	ATP binding site [chemical binding]; other site
543734000671	Q-loop/lid; other site
543734000672	ABC transporter signature motif; other site
543734000673	Walker B; other site
543734000674	D-loop; other site
543734000675	H-loop/switch region; other site
543734000676	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
543734000677	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
543734000678	Walker A/P-loop; other site
543734000679	ATP binding site [chemical binding]; other site
543734000680	Q-loop/lid; other site
543734000681	ABC transporter signature motif; other site
543734000682	Walker B; other site
543734000683	D-loop; other site
543734000684	H-loop/switch region; other site
543734000685	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
543734000686	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
543734000687	Class I aldolases; Region: Aldolase_Class_I; cl17187
543734000688	catalytic residue [active]
543734000689	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
543734000690	intersubunit interface [polypeptide binding]; other site
543734000691	active site
543734000692	catalytic residue [active]
543734000693	phosphopentomutase; Provisional; Region: PRK05362
543734000694	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
543734000695	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
543734000696	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
543734000697	NlpC/P60 family; Region: NLPC_P60; pfam00877
543734000698	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
543734000699	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
543734000700	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
543734000701	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
543734000702	DEAD/DEAH box helicase; Region: DEAD; pfam00270
543734000703	DEAD_2; Region: DEAD_2; pfam06733
543734000704	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
543734000705	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
543734000706	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
543734000707	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
543734000708	active site
543734000709	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
543734000710	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
543734000711	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
543734000712	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
543734000713	DNA-binding site [nucleotide binding]; DNA binding site
543734000714	UTRA domain; Region: UTRA; pfam07702
543734000715	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
543734000716	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
543734000717	dimer interface [polypeptide binding]; other site
543734000718	active site
543734000719	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
543734000720	putative active site [active]
543734000721	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
543734000722	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
543734000723	active site
543734000724	dimer interface [polypeptide binding]; other site
543734000725	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
543734000726	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
543734000727	active site
543734000728	phosphorylation site [posttranslational modification]
543734000729	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
543734000730	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
543734000731	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
543734000732	active pocket/dimerization site; other site
543734000733	active site
543734000734	phosphorylation site [posttranslational modification]
543734000735	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
543734000736	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
543734000737	Transposase domain (DUF772); Region: DUF772; pfam05598
543734000738	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
543734000739	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
543734000740	pyridoxal 5'-phosphate binding site [chemical binding]; other site
543734000741	homodimer interface [polypeptide binding]; other site
543734000742	catalytic residue [active]
543734000743	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
543734000744	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
543734000745	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
543734000746	active site
543734000747	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
543734000748	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
543734000749	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
543734000750	active site
543734000751	P-loop; other site
543734000752	phosphorylation site [posttranslational modification]
543734000753	PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255
543734000754	active site
543734000755	methionine cluster; other site
543734000756	phosphorylation site [posttranslational modification]
543734000757	metal binding site [ion binding]; metal-binding site
543734000758	exoaminopeptidase; Provisional; Region: PRK09961
543734000759	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
543734000760	oligomer interface [polypeptide binding]; other site
543734000761	active site
543734000762	metal binding site [ion binding]; metal-binding site
543734000763	HTH domain; Region: HTH_11; pfam08279
543734000764	PRD domain; Region: PRD; pfam00874
543734000765	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
543734000766	active site
543734000767	P-loop; other site
543734000768	phosphorylation site [posttranslational modification]
543734000769	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
543734000770	active site
543734000771	phosphorylation site [posttranslational modification]
543734000772	peptidase T; Region: peptidase-T; TIGR01882
543734000773	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
543734000774	metal binding site [ion binding]; metal-binding site
543734000775	dimer interface [polypeptide binding]; other site
543734000776	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
543734000777	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
543734000778	peptide binding site [polypeptide binding]; other site
543734000779	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
543734000780	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
543734000781	Coenzyme A binding pocket [chemical binding]; other site
543734000782	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943
543734000783	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
543734000784	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
543734000785	Walker A/P-loop; other site
543734000786	ATP binding site [chemical binding]; other site
543734000787	Q-loop/lid; other site
543734000788	ABC transporter signature motif; other site
543734000789	Walker B; other site
543734000790	D-loop; other site
543734000791	H-loop/switch region; other site
543734000792	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
543734000793	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734000794	Walker A/P-loop; other site
543734000795	ATP binding site [chemical binding]; other site
543734000796	Q-loop/lid; other site
543734000797	ABC transporter signature motif; other site
543734000798	Walker B; other site
543734000799	D-loop; other site
543734000800	H-loop/switch region; other site
543734000801	Cobalt transport protein; Region: CbiQ; cl00463
543734000802	Putative transcription activator [Transcription]; Region: TenA; COG0819
543734000803	Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952
543734000804	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
543734000805	substrate binding site [chemical binding]; other site
543734000806	multimerization interface [polypeptide binding]; other site
543734000807	ATP binding site [chemical binding]; other site
543734000808	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
543734000809	thiamine phosphate binding site [chemical binding]; other site
543734000810	active site
543734000811	pyrophosphate binding site [ion binding]; other site
543734000812	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
543734000813	dimer interface [polypeptide binding]; other site
543734000814	substrate binding site [chemical binding]; other site
543734000815	ATP binding site [chemical binding]; other site
543734000816	Amino acid permease; Region: AA_permease_2; pfam13520
543734000817	hypothetical protein
543734000818	Transcriptional regulators [Transcription]; Region: PurR; COG1609
543734000819	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
543734000820	DNA binding site [nucleotide binding]
543734000821	domain linker motif; other site
543734000822	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
543734000823	ligand binding site [chemical binding]; other site
543734000824	dimerization interface [polypeptide binding]; other site
543734000825	D-ribose pyranase; Provisional; Region: PRK11797
543734000826	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
543734000827	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
543734000828	Walker A/P-loop; other site
543734000829	ATP binding site [chemical binding]; other site
543734000830	Q-loop/lid; other site
543734000831	ABC transporter signature motif; other site
543734000832	Walker B; other site
543734000833	D-loop; other site
543734000834	H-loop/switch region; other site
543734000835	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
543734000836	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
543734000837	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
543734000838	TM-ABC transporter signature motif; other site
543734000839	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
543734000840	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
543734000841	ligand binding site [chemical binding]; other site
543734000842	dimerization interface [polypeptide binding]; other site
543734000843	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
543734000844	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
543734000845	substrate binding site [chemical binding]; other site
543734000846	dimer interface [polypeptide binding]; other site
543734000847	ATP binding site [chemical binding]; other site
543734000848	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
543734000849	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
543734000850	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
543734000851	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
543734000852	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
543734000853	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734000854	Major Facilitator Superfamily; Region: MFS_1; pfam07690
543734000855	putative substrate translocation pore; other site
543734000856	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734000857	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
543734000858	MarR family; Region: MarR_2; pfam12802
543734000859	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
543734000860	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734000861	ABC transporter signature motif; other site
543734000862	Walker B; other site
543734000863	D-loop; other site
543734000864	H-loop/switch region; other site
543734000865	Transposase domain (DUF772); Region: DUF772; pfam05598
543734000866	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
543734000867	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734000868	Walker A/P-loop; other site
543734000869	ATP binding site [chemical binding]; other site
543734000870	Q-loop/lid; other site
543734000871	fumarate reductase flavoprotein subunit; Validated; Region: PRK06481
543734000872	L-aspartate oxidase; Provisional; Region: PRK06175
543734000873	Predicted oxidoreductase [General function prediction only]; Region: COG3573
543734000874	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
543734000875	Mga helix-turn-helix domain; Region: Mga; pfam05043
543734000876	PRD domain; Region: PRD; pfam00874
543734000877	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
543734000878	active site
543734000879	P-loop; other site
543734000880	phosphorylation site [posttranslational modification]
543734000881	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
543734000882	active site
543734000883	phosphorylation site [posttranslational modification]
543734000884	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
543734000885	active site
543734000886	P-loop; other site
543734000887	phosphorylation site [posttranslational modification]
543734000888	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
543734000889	Fructose-bisphosphate aldolase class-II; Region: F_bP_aldolase; pfam01116
543734000890	active site
543734000891	intersubunit interface [polypeptide binding]; other site
543734000892	zinc binding site [ion binding]; other site
543734000893	Na+ binding site [ion binding]; other site
543734000894	AAA domain; Region: AAA_17; cl17253
543734000895	AAA domain; Region: AAA_18; pfam13238
543734000896	Predicted transcriptional regulators [Transcription]; Region: COG1378
543734000897	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
543734000898	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
543734000899	C-terminal domain interface [polypeptide binding]; other site
543734000900	sugar binding site [chemical binding]; other site
543734000901	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
543734000902	ornithine cyclodeaminase; Validated; Region: PRK08618
543734000903	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
543734000904	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
543734000905	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
543734000906	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
543734000907	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
543734000908	Helix-turn-helix domain; Region: HTH_38; pfam13936
543734000909	Integrase core domain; Region: rve; pfam00665
543734000910	hypothetical protein
543734000911	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
543734000912	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
543734000913	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
543734000914	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
543734000915	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
543734000916	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
543734000917	conserved hypothetical protein; Region: TIGR02328
543734000918	Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013
543734000919	Transposase domain (DUF772); Region: DUF772; pfam05598
543734000920	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
543734000921	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
543734000922	Transcriptional regulators [Transcription]; Region: PurR; COG1609
543734000923	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
543734000924	DNA binding site [nucleotide binding]
543734000925	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
543734000926	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
543734000927	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
543734000928	Sulfatase; Region: Sulfatase; cl17466
543734000929	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
543734000930	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
543734000931	Helix-turn-helix domain; Region: HTH_38; pfam13936
543734000932	Integrase core domain; Region: rve; pfam00665
543734000933	potential protein location (hypothetical protein) that overlaps protein (transposase)
543734000934	hypothetical protein
543734000935	Uncharacterized conserved protein [Function unknown]; Region: COG1262
543734000936	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
543734000937	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
543734000938	anaerobic sulfatase-maturase; Provisional; Region: PRK13758
543734000939	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
543734000940	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
543734000941	active site
543734000942	tetramer interface [polypeptide binding]; other site
543734000943	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
543734000944	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069
543734000945	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
543734000946	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
543734000947	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
543734000948	DNA-binding site [nucleotide binding]; DNA binding site
543734000949	Predicted esterase [General function prediction only]; Region: COG0627
543734000950	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
543734000951	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
543734000952	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
543734000953	active site
543734000954	phosphorylation site [posttranslational modification]
543734000955	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
543734000956	active pocket/dimerization site; other site
543734000957	active site
543734000958	phosphorylation site [posttranslational modification]
543734000959	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
543734000960	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
543734000961	Walker A motif; other site
543734000962	ATP binding site [chemical binding]; other site
543734000963	Walker B motif; other site
543734000964	arginine finger; other site
543734000965	Transcriptional antiterminator [Transcription]; Region: COG3933
543734000966	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
543734000967	active pocket/dimerization site; other site
543734000968	active site
543734000969	phosphorylation site [posttranslational modification]
543734000970	PRD domain; Region: PRD; pfam00874
543734000971	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
543734000972	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
543734000973	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
543734000974	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
543734000975	HTH domain; Region: HTH_11; pfam08279
543734000976	Mga helix-turn-helix domain; Region: Mga; pfam05043
543734000977	PRD domain; Region: PRD; pfam00874
543734000978	PRD domain; Region: PRD; pfam00874
543734000979	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
543734000980	active site
543734000981	P-loop; other site
543734000982	phosphorylation site [posttranslational modification]
543734000983	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
543734000984	active site
543734000985	phosphorylation site [posttranslational modification]
543734000986	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
543734000987	intersubunit interface [polypeptide binding]; other site
543734000988	active site
543734000989	zinc binding site [ion binding]; other site
543734000990	Na+ binding site [ion binding]; other site
543734000991	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
543734000992	active site
543734000993	phosphorylation site [posttranslational modification]
543734000994	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
543734000995	active site
543734000996	P-loop; other site
543734000997	phosphorylation site [posttranslational modification]
543734000998	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
543734000999	Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
543734001000	active site
543734001001	catalytic residues [active]
543734001002	Protein of unknown function (DUF1498); Region: DUF1498; cl17840
543734001003	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
543734001004	N- and C-terminal domain interface [polypeptide binding]; other site
543734001005	D-xylulose kinase; Region: XylB; TIGR01312
543734001006	active site
543734001007	MgATP binding site [chemical binding]; other site
543734001008	catalytic site [active]
543734001009	metal binding site [ion binding]; metal-binding site
543734001010	xylulose binding site [chemical binding]; other site
543734001011	homodimer interface [polypeptide binding]; other site
543734001012	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
543734001013	Helix-turn-helix domain; Region: HTH_38; pfam13936
543734001014	Integrase core domain; Region: rve; pfam00665
543734001015	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
543734001016	active site
543734001017	phosphorylation site [posttranslational modification]
543734001018	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
543734001019	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
543734001020	active site
543734001021	P-loop; other site
543734001022	phosphorylation site [posttranslational modification]
543734001023	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
543734001024	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
543734001025	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
543734001026	pyridoxal 5'-phosphate binding site [chemical binding]; other site
543734001027	homodimer interface [polypeptide binding]; other site
543734001028	catalytic residue [active]
543734001029	putative frv operon regulatory protein; Provisional; Region: PRK09863
543734001030	HTH domain; Region: HTH_11; pfam08279
543734001031	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
543734001032	active site
543734001033	phosphorylation site [posttranslational modification]
543734001034	HTH domain; Region: HTH_11; pfam08279
543734001035	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
543734001036	PRD domain; Region: PRD; pfam00874
543734001037	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
543734001038	active site
543734001039	phosphorylation site [posttranslational modification]
543734001040	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
543734001041	intersubunit interface [polypeptide binding]; other site
543734001042	active site
543734001043	zinc binding site [ion binding]; other site
543734001044	Na+ binding site [ion binding]; other site
543734001045	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
543734001046	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
543734001047	active site
543734001048	phosphorylation site [posttranslational modification]
543734001049	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
543734001050	active site
543734001051	P-loop; other site
543734001052	phosphorylation site [posttranslational modification]
543734001053	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
543734001054	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
543734001055	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
543734001056	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
543734001057	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
543734001058	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
543734001059	sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171
543734001060	classical (c) SDRs; Region: SDR_c; cd05233
543734001061	NAD(P) binding site [chemical binding]; other site
543734001062	active site
543734001063	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
543734001064	active pocket/dimerization site; other site
543734001065	active site
543734001066	phosphorylation site [posttranslational modification]
543734001067	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
543734001068	active site
543734001069	phosphorylation site [posttranslational modification]
543734001070	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
543734001071	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
543734001072	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
543734001073	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
543734001074	DAK2 domain; Region: Dak2; pfam02734
543734001075	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
543734001076	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
543734001077	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
543734001078	active site
543734001079	dimer interface [polypeptide binding]; other site
543734001080	magnesium binding site [ion binding]; other site
543734001081	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
543734001082	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
543734001083	tetramer interface [polypeptide binding]; other site
543734001084	active site
543734001085	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
543734001086	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
543734001087	DNA-binding site [nucleotide binding]; DNA binding site
543734001088	UTRA domain; Region: UTRA; pfam07702
543734001089	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
543734001090	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
543734001091	putative NAD(P) binding site [chemical binding]; other site
543734001092	catalytic Zn binding site [ion binding]; other site
543734001093	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
543734001094	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
543734001095	sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171
543734001096	classical (c) SDRs; Region: SDR_c; cd05233
543734001097	NAD(P) binding site [chemical binding]; other site
543734001098	active site
543734001099	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
543734001100	active pocket/dimerization site; other site
543734001101	active site
543734001102	phosphorylation site [posttranslational modification]
543734001103	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
543734001104	active site
543734001105	phosphorylation site [posttranslational modification]
543734001106	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
543734001107	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
543734001108	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
543734001109	intersubunit interface [polypeptide binding]; other site
543734001110	active site
543734001111	zinc binding site [ion binding]; other site
543734001112	Na+ binding site [ion binding]; other site
543734001113	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
543734001114	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
543734001115	transmembrane helices; other site
543734001116	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
543734001117	Transcriptional regulator [Transcription]; Region: LysR; COG0583
543734001118	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
543734001119	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
543734001120	dimerization interface [polypeptide binding]; other site
543734001121	Uncharacterized conserved protein [Function unknown]; Region: COG1912
543734001122	hypothetical protein; Provisional; Region: PRK13661
543734001123	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
543734001124	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
543734001125	Walker A/P-loop; other site
543734001126	ATP binding site [chemical binding]; other site
543734001127	Q-loop/lid; other site
543734001128	ABC transporter signature motif; other site
543734001129	Walker B; other site
543734001130	D-loop; other site
543734001131	H-loop/switch region; other site
543734001132	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
543734001133	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
543734001134	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
543734001135	Walker A/P-loop; other site
543734001136	ATP binding site [chemical binding]; other site
543734001137	Q-loop/lid; other site
543734001138	ABC transporter signature motif; other site
543734001139	Walker B; other site
543734001140	D-loop; other site
543734001141	H-loop/switch region; other site
543734001142	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
543734001143	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
543734001144	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
543734001145	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
543734001146	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
543734001147	Transcriptional antiterminator [Transcription]; Region: COG3933
543734001148	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
543734001149	active pocket/dimerization site; other site
543734001150	active site
543734001151	phosphorylation site [posttranslational modification]
543734001152	PRD domain; Region: PRD; pfam00874
543734001153	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
543734001154	active pocket/dimerization site; other site
543734001155	active site
543734001156	phosphorylation site [posttranslational modification]
543734001157	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
543734001158	active site
543734001159	phosphorylation site [posttranslational modification]
543734001160	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
543734001161	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
543734001162	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
543734001163	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734001164	motif II; other site
543734001165	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
543734001166	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
543734001167	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
543734001168	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
543734001169	active site
543734001170	dimer interface [polypeptide binding]; other site
543734001171	magnesium binding site [ion binding]; other site
543734001172	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
543734001173	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
543734001174	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
543734001175	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
543734001176	active site
543734001177	P-loop; other site
543734001178	phosphorylation site [posttranslational modification]
543734001179	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
543734001180	active site
543734001181	phosphorylation site [posttranslational modification]
543734001182	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
543734001183	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
543734001184	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
543734001185	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
543734001186	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
543734001187	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
543734001188	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734001189	Walker A/P-loop; other site
543734001190	ATP binding site [chemical binding]; other site
543734001191	Q-loop/lid; other site
543734001192	ABC transporter signature motif; other site
543734001193	Walker B; other site
543734001194	D-loop; other site
543734001195	H-loop/switch region; other site
543734001196	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
543734001197	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
543734001198	substrate binding pocket [chemical binding]; other site
543734001199	membrane-bound complex binding site; other site
543734001200	hinge residues; other site
543734001201	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
543734001202	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734001203	dimer interface [polypeptide binding]; other site
543734001204	conserved gate region; other site
543734001205	putative PBP binding loops; other site
543734001206	ABC-ATPase subunit interface; other site
543734001207	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734001208	dimer interface [polypeptide binding]; other site
543734001209	conserved gate region; other site
543734001210	putative PBP binding loops; other site
543734001211	ABC-ATPase subunit interface; other site
543734001212	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
543734001213	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734001214	putative substrate translocation pore; other site
543734001215	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
543734001216	YvrJ protein family; Region: YvrJ; pfam12841
543734001217	AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522
543734001218	active site
543734001219	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
543734001220	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
543734001221	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
543734001222	classical (c) SDRs; Region: SDR_c; cd05233
543734001223	NAD(P) binding site [chemical binding]; other site
543734001224	active site
543734001225	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
543734001226	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
543734001227	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
543734001228	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
543734001229	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
543734001230	FtsX-like permease family; Region: FtsX; pfam02687
543734001231	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
543734001232	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
543734001233	Walker A/P-loop; other site
543734001234	ATP binding site [chemical binding]; other site
543734001235	Q-loop/lid; other site
543734001236	ABC transporter signature motif; other site
543734001237	Walker B; other site
543734001238	D-loop; other site
543734001239	H-loop/switch region; other site
543734001240	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734001241	non-specific DNA binding site [nucleotide binding]; other site
543734001242	salt bridge; other site
543734001243	sequence-specific DNA binding site [nucleotide binding]; other site
543734001244	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
543734001245	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
543734001246	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
543734001247	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734001248	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
543734001249	active site
543734001250	motif I; other site
543734001251	motif II; other site
543734001252	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
543734001253	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
543734001254	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
543734001255	Transcriptional regulators [Transcription]; Region: PurR; COG1609
543734001256	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
543734001257	DNA binding site [nucleotide binding]
543734001258	domain linker motif; other site
543734001259	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
543734001260	putative dimerization interface [polypeptide binding]; other site
543734001261	putative ligand binding site [chemical binding]; other site
543734001262	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
543734001263	active site
543734001264	phosphorylation site [posttranslational modification]
543734001265	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
543734001266	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
543734001267	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
543734001268	This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595
543734001269	putative active site [active]
543734001270	putative catalytic site [active]
543734001271	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
543734001272	active pocket/dimerization site; other site
543734001273	active site
543734001274	phosphorylation site [posttranslational modification]
543734001275	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
543734001276	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
543734001277	Ca binding site [ion binding]; other site
543734001278	active site
543734001279	catalytic site [active]
543734001280	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
543734001281	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734001282	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
543734001283	Walker A/P-loop; other site
543734001284	ATP binding site [chemical binding]; other site
543734001285	Q-loop/lid; other site
543734001286	ABC transporter signature motif; other site
543734001287	Walker B; other site
543734001288	D-loop; other site
543734001289	H-loop/switch region; other site
543734001290	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
543734001291	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
543734001292	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
543734001293	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
543734001294	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734001295	Walker A/P-loop; other site
543734001296	ATP binding site [chemical binding]; other site
543734001297	Q-loop/lid; other site
543734001298	ABC transporter signature motif; other site
543734001299	Walker B; other site
543734001300	D-loop; other site
543734001301	H-loop/switch region; other site
543734001302	Predicted membrane protein [Function unknown]; Region: COG1511
543734001303	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
543734001304	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
543734001305	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
543734001306	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
543734001307	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
543734001308	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
543734001309	active site
543734001310	myosin-cross-reactive antigen; Provisional; Region: PRK13977
543734001311	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
543734001312	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
543734001313	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
543734001314	DAK2 domain; Region: Dak2; cl03685
543734001315	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
543734001316	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
543734001317	OsmC-like protein; Region: OsmC; cl00767
543734001318	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
543734001319	active site
543734001320	catalytic site [active]
543734001321	substrate binding site [chemical binding]; other site
543734001322	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
543734001323	dimerization interface [polypeptide binding]; other site
543734001324	putative DNA binding site [nucleotide binding]; other site
543734001325	putative Zn2+ binding site [ion binding]; other site
543734001326	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734001327	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
543734001328	putative substrate translocation pore; other site
543734001329	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
543734001330	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
543734001331	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
543734001332	intersubunit interface [polypeptide binding]; other site
543734001333	active site
543734001334	zinc binding site [ion binding]; other site
543734001335	Na+ binding site [ion binding]; other site
543734001336	pyruvate oxidase; Provisional; Region: PRK08611
543734001337	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
543734001338	PYR/PP interface [polypeptide binding]; other site
543734001339	dimer interface [polypeptide binding]; other site
543734001340	tetramer interface [polypeptide binding]; other site
543734001341	TPP binding site [chemical binding]; other site
543734001342	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
543734001343	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
543734001344	TPP-binding site [chemical binding]; other site
543734001345	Beta-lactamase; Region: Beta-lactamase; pfam00144
543734001346	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
543734001347	Methyltransferase domain; Region: Methyltransf_31; pfam13847
543734001348	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
543734001349	S-adenosylmethionine binding site [chemical binding]; other site
543734001350	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
543734001351	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
543734001352	catalytic triad [active]
543734001353	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
543734001354	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
543734001355	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
543734001356	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
543734001357	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
543734001358	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
543734001359	DNA binding residues [nucleotide binding]
543734001360	putative dimer interface [polypeptide binding]; other site
543734001361	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
543734001362	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
543734001363	active site
543734001364	catalytic tetrad [active]
543734001365	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
543734001366	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
543734001367	putative NAD(P) binding site [chemical binding]; other site
543734001368	dimer interface [polypeptide binding]; other site
543734001369	Predicted transcriptional regulators [Transcription]; Region: COG1733
543734001370	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
543734001371	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
543734001372	beta-galactosidase; Region: BGL; TIGR03356
543734001373	PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255
543734001374	active site
543734001375	methionine cluster; other site
543734001376	phosphorylation site [posttranslational modification]
543734001377	metal binding site [ion binding]; metal-binding site
543734001378	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
543734001379	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
543734001380	active site
543734001381	P-loop; other site
543734001382	phosphorylation site [posttranslational modification]
543734001383	HTH domain; Region: HTH_11; cl17392
543734001384	Mga helix-turn-helix domain; Region: Mga; pfam05043
543734001385	PRD domain; Region: PRD; pfam00874
543734001386	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
543734001387	active site
543734001388	phosphorylation site [posttranslational modification]
543734001389	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
543734001390	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
543734001391	catalytic residues [active]
543734001392	catalytic nucleophile [active]
543734001393	Presynaptic Site I dimer interface [polypeptide binding]; other site
543734001394	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
543734001395	Synaptic Flat tetramer interface [polypeptide binding]; other site
543734001396	Synaptic Site I dimer interface [polypeptide binding]; other site
543734001397	DNA binding site [nucleotide binding]
543734001398	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
543734001399	metal ion-dependent adhesion site (MIDAS); other site
543734001400	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
543734001401	domain interaction interfaces [polypeptide binding]; other site
543734001402	Cna protein B-type domain; Region: Cna_B; pfam05738
543734001403	Cna protein B-type domain; Region: Cna_B; pfam05738
543734001404	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
543734001405	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
543734001406	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
543734001407	active site
543734001408	catalytic site [active]
543734001409	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
543734001410	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
543734001411	Walker A/P-loop; other site
543734001412	ATP binding site [chemical binding]; other site
543734001413	Q-loop/lid; other site
543734001414	ABC transporter signature motif; other site
543734001415	Walker B; other site
543734001416	D-loop; other site
543734001417	H-loop/switch region; other site
543734001418	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
543734001419	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
543734001420	active site
543734001421	phosphorylation site [posttranslational modification]
543734001422	intermolecular recognition site; other site
543734001423	dimerization interface [polypeptide binding]; other site
543734001424	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
543734001425	DNA binding site [nucleotide binding]
543734001426	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
543734001427	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
543734001428	dimerization interface [polypeptide binding]; other site
543734001429	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
543734001430	dimer interface [polypeptide binding]; other site
543734001431	phosphorylation site [posttranslational modification]
543734001432	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
543734001433	ATP binding site [chemical binding]; other site
543734001434	Mg2+ binding site [ion binding]; other site
543734001435	G-X-G motif; other site
543734001436	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734001437	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
543734001438	Walker A/P-loop; other site
543734001439	ATP binding site [chemical binding]; other site
543734001440	ABC transporter; Region: ABC_tran; pfam00005
543734001441	Q-loop/lid; other site
543734001442	ABC transporter signature motif; other site
543734001443	Walker B; other site
543734001444	D-loop; other site
543734001445	H-loop/switch region; other site
543734001446	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
543734001447	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
543734001448	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
543734001449	catalytic triad [active]
543734001450	putative active site [active]
543734001451	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
543734001452	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
543734001453	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
543734001454	catalytic triad [active]
543734001455	putative active site [active]
543734001456	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
543734001457	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
543734001458	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
543734001459	Zn binding site [ion binding]; other site
543734001460	inner membrane transporter YjeM; Provisional; Region: PRK15238
543734001461	Protein of unknown function (DUF1440); Region: DUF1440; pfam07274
543734001462	Transcriptional regulator [Transcription]; Region: LysR; COG0583
543734001463	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
543734001464	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
543734001465	putative dimerization interface [polypeptide binding]; other site
543734001466	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
543734001467	classical (c) SDRs; Region: SDR_c; cd05233
543734001468	NAD(P) binding site [chemical binding]; other site
543734001469	active site
543734001470	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
543734001471	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
543734001472	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
543734001473	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
543734001474	shikimate binding site; other site
543734001475	NAD(P) binding site [chemical binding]; other site
543734001476	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734001477	putative substrate translocation pore; other site
543734001478	Major Facilitator Superfamily; Region: MFS_1; pfam07690
543734001479	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
543734001480	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
543734001481	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
543734001482	shikimate binding site; other site
543734001483	NAD(P) binding site [chemical binding]; other site
543734001484	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
543734001485	proposed active site lysine [active]
543734001486	conserved cys residue [active]
543734001487	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
543734001488	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
543734001489	dimer interface [polypeptide binding]; other site
543734001490	pyridoxal 5'-phosphate binding site [chemical binding]; other site
543734001491	catalytic residue [active]
543734001492	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
543734001493	Int/Topo IB signature motif; other site
543734001494	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
543734001495	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
543734001496	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734001497	non-specific DNA binding site [nucleotide binding]; other site
543734001498	salt bridge; other site
543734001499	sequence-specific DNA binding site [nucleotide binding]; other site
543734001500	Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509
543734001501	ORF6N domain; Region: ORF6N; pfam10543
543734001502	ORF6C domain; Region: ORF6C; pfam10552
543734001503	Domain of unknown function (DUF1883); Region: DUF1883; pfam08980
543734001504	Domain of unknown function (DUF771); Region: DUF771; pfam05595
543734001505	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
543734001506	Helix-turn-helix domain; Region: HTH_36; pfam13730
543734001507	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
543734001508	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
543734001509	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
543734001510	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
543734001511	Walker A motif; other site
543734001512	ATP binding site [chemical binding]; other site
543734001513	Walker B motif; other site
543734001514	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
543734001515	active site
543734001516	catalytic site [active]
543734001517	substrate binding site [chemical binding]; other site
543734001518	hypothetical protein
543734001519	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
543734001520	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
543734001521	Helix-turn-helix domain; Region: HTH_38; pfam13936
543734001522	Integrase core domain; Region: rve; pfam00665
543734001523	GcrA cell cycle regulator; Region: GcrA; cl11564
543734001524	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
543734001525	Transposase; Region: HTH_Tnp_1; pfam01527
543734001526	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
543734001527	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
543734001528	Homeodomain-like domain; Region: HTH_23; cl17451
543734001529	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
543734001530	Transposase; Region: HTH_Tnp_1; cl17663
543734001531	Helix-turn-helix domain; Region: HTH_28; pfam13518
543734001532	putative transposase OrfB; Reviewed; Region: PHA02517
543734001533	HTH-like domain; Region: HTH_21; pfam13276
543734001534	Integrase core domain; Region: rve; pfam00665
543734001535	Integrase core domain; Region: rve_3; pfam13683
543734001536	HTH-like domain; Region: HTH_21; pfam13276
543734001537	Integrase core domain; Region: rve; pfam00665
543734001538	Integrase core domain; Region: rve_3; cl15866
543734001539	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
543734001540	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
543734001541	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
543734001542	generic binding surface II; other site
543734001543	generic binding surface I; other site
543734001544	AAA-like domain; Region: AAA_10; pfam12846
543734001545	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
543734001546	Walker A motif; other site
543734001547	ATP binding site [chemical binding]; other site
543734001548	Walker B motif; other site
543734001549	hypothetical protein; Provisional; Region: PRK12495
543734001550	AAA-like domain; Region: AAA_10; pfam12846
543734001551	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
543734001552	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
543734001553	NlpC/P60 family; Region: NLPC_P60; cl17555
543734001554	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
543734001555	catalytic residues [active]
543734001556	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
543734001557	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
543734001558	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
543734001559	Toprim-like; Region: Toprim_2; pfam13155
543734001560	hypothetical protein
543734001561	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
543734001562	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
543734001563	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
543734001564	active site
543734001565	catalytic site [active]
543734001566	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
543734001567	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
543734001568	Cl- selectivity filter; other site
543734001569	Cl- binding residues [ion binding]; other site
543734001570	pore gating glutamate residue; other site
543734001571	dimer interface [polypeptide binding]; other site
543734001572	H+/Cl- coupling transport residue; other site
543734001573	TrkA-C domain; Region: TrkA_C; pfam02080
543734001574	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
543734001575	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
543734001576	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
543734001577	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
543734001578	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
543734001579	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
543734001580	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
543734001581	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734001582	active site
543734001583	motif I; other site
543734001584	motif II; other site
543734001585	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
543734001586	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
543734001587	Integrase core domain; Region: rve; pfam00665
543734001588	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
543734001589	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
543734001590	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
543734001591	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
543734001592	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
543734001593	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
543734001594	Integrase core domain; Region: rve; pfam00665
543734001595	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
543734001596	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
543734001597	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
543734001598	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
543734001599	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021
543734001600	active site
543734001601	phosphorylation site [posttranslational modification]
543734001602	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
543734001603	active pocket/dimerization site; other site
543734001604	active site
543734001605	phosphorylation site [posttranslational modification]
543734001606	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
543734001607	intersubunit interface [polypeptide binding]; other site
543734001608	active site
543734001609	catalytic residue [active]
543734001610	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
543734001611	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
543734001612	DNA-binding site [nucleotide binding]; DNA binding site
543734001613	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
543734001614	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
543734001615	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
543734001616	catalytic residues [active]
543734001617	catalytic nucleophile [active]
543734001618	Presynaptic Site I dimer interface [polypeptide binding]; other site
543734001619	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
543734001620	Synaptic Flat tetramer interface [polypeptide binding]; other site
543734001621	Synaptic Site I dimer interface [polypeptide binding]; other site
543734001622	DNA binding site [nucleotide binding]
543734001623	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
543734001624	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
543734001625	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
543734001626	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
543734001627	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
543734001628	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
543734001629	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
543734001630	HTH-like domain; Region: HTH_21; pfam13276
543734001631	DDE domain; Region: DDE_Tnp_IS240; pfam13610
543734001632	Integrase core domain; Region: rve; pfam00665
543734001633	Integrase core domain; Region: rve_3; pfam13683
543734001634	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
543734001635	Transposase; Region: HTH_Tnp_1; pfam01527
543734001636	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
543734001637	ApbE family; Region: ApbE; pfam02424
543734001638	Predicted flavoprotein [General function prediction only]; Region: COG0431
543734001639	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
543734001640	Predicted flavoprotein [General function prediction only]; Region: COG0431
543734001641	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
543734001642	PAS domain; Region: PAS_10; pfam13596
543734001643	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
543734001644	Transposase; Region: HTH_Tnp_1; pfam01527
543734001645	HTH-like domain; Region: HTH_21; pfam13276
543734001646	DDE domain; Region: DDE_Tnp_IS240; pfam13610
543734001647	Integrase core domain; Region: rve; pfam00665
543734001648	Integrase core domain; Region: rve_3; pfam13683
543734001649	D-lactate dehydrogenase; Provisional; Region: PRK11183
543734001650	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
543734001651	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
543734001652	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
543734001653	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
543734001654	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
543734001655	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
543734001656	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
543734001657	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
543734001658	transmembrane helices; other site
543734001659	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
543734001660	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
543734001661	Transposase; Region: HTH_Tnp_1; cl17663
543734001662	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
543734001663	active site
543734001664	Bacterial SH3 domain; Region: SH3_5; pfam08460
543734001665	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
543734001666	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
543734001667	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
543734001668	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
543734001669	homodimer interface [polypeptide binding]; other site
543734001670	substrate-cofactor binding pocket; other site
543734001671	pyridoxal 5'-phosphate binding site [chemical binding]; other site
543734001672	catalytic residue [active]
543734001673	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
543734001674	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
543734001675	substrate binding pocket [chemical binding]; other site
543734001676	membrane-bound complex binding site; other site
543734001677	hinge residues; other site
543734001678	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734001679	dimer interface [polypeptide binding]; other site
543734001680	conserved gate region; other site
543734001681	putative PBP binding loops; other site
543734001682	ABC-ATPase subunit interface; other site
543734001683	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
543734001684	WxL domain surface cell wall-binding; Region: WxL; pfam13731
543734001685	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
543734001686	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
543734001687	legume lectins; Region: lectin_L-type; cd01951
543734001688	homotetramer interaction site [polypeptide binding]; other site
543734001689	homodimer interaction site [polypeptide binding]; other site
543734001690	carbohydrate binding site [chemical binding]; other site
543734001691	metal binding site [ion binding]; metal-binding site
543734001692	WxL domain surface cell wall-binding; Region: WxL; pfam13731
543734001693	WxL domain surface cell wall-binding; Region: WxL; pfam13731
543734001694	WxL domain surface cell wall-binding; Region: WxL; pfam13731
543734001695	legume lectins; Region: lectin_L-type; cd01951
543734001696	homotetramer interaction site [polypeptide binding]; other site
543734001697	carbohydrate binding site [chemical binding]; other site
543734001698	metal binding site [ion binding]; metal-binding site
543734001699	WxL domain surface cell wall-binding; Region: WxL; pfam13731
543734001700	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
543734001701	EamA-like transporter family; Region: EamA; pfam00892
543734001702	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
543734001703	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
543734001704	Walker A/P-loop; other site
543734001705	ATP binding site [chemical binding]; other site
543734001706	Q-loop/lid; other site
543734001707	ABC transporter signature motif; other site
543734001708	Walker B; other site
543734001709	D-loop; other site
543734001710	H-loop/switch region; other site
543734001711	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
543734001712	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
543734001713	substrate binding site [chemical binding]; other site
543734001714	ATP binding site [chemical binding]; other site
543734001715	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
543734001716	FAD binding site [chemical binding]; other site
543734001717	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
543734001718	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
543734001719	THF binding site; other site
543734001720	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
543734001721	substrate binding site [chemical binding]; other site
543734001722	THF binding site; other site
543734001723	zinc-binding site [ion binding]; other site
543734001724	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
543734001725	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
543734001726	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734001727	Walker A/P-loop; other site
543734001728	ATP binding site [chemical binding]; other site
543734001729	Q-loop/lid; other site
543734001730	ABC transporter signature motif; other site
543734001731	Walker B; other site
543734001732	D-loop; other site
543734001733	H-loop/switch region; other site
543734001734	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
543734001735	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
543734001736	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
543734001737	Walker A/P-loop; other site
543734001738	ATP binding site [chemical binding]; other site
543734001739	Q-loop/lid; other site
543734001740	ABC transporter signature motif; other site
543734001741	Walker B; other site
543734001742	D-loop; other site
543734001743	H-loop/switch region; other site
543734001744	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
543734001745	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734001746	putative substrate translocation pore; other site
543734001747	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
543734001748	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
543734001749	DNA-binding site [nucleotide binding]; DNA binding site
543734001750	UTRA domain; Region: UTRA; pfam07702
543734001751	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
543734001752	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
543734001753	Ca binding site [ion binding]; other site
543734001754	active site
543734001755	catalytic site [active]
543734001756	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
543734001757	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
543734001758	HPr interaction site; other site
543734001759	glycerol kinase (GK) interaction site [polypeptide binding]; other site
543734001760	active site
543734001761	phosphorylation site [posttranslational modification]
543734001762	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
543734001763	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
543734001764	active site turn [active]
543734001765	phosphorylation site [posttranslational modification]
543734001766	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
543734001767	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
543734001768	serine/threonine transporter SstT; Provisional; Region: PRK13628
543734001769	amino acid transporter; Region: 2A0306; TIGR00909
543734001770	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
543734001771	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
543734001772	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
543734001773	NAD binding site [chemical binding]; other site
543734001774	dimer interface [polypeptide binding]; other site
543734001775	tetramer (dimer of dimers) interface [polypeptide binding]; other site
543734001776	substrate binding site [chemical binding]; other site
543734001777	glutamate dehydrogenase; Provisional; Region: PRK09414
543734001778	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
543734001779	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
543734001780	NAD(P) binding site [chemical binding]; other site
543734001781	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
543734001782	DNA-binding site [nucleotide binding]; DNA binding site
543734001783	RNA-binding motif; other site
543734001784	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
543734001785	OsmC-like protein; Region: OsmC; pfam02566
543734001786	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
543734001787	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
543734001788	ABC transporter; Region: ABC_tran_2; pfam12848
543734001789	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
543734001790	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
543734001791	NADH(P)-binding; Region: NAD_binding_10; pfam13460
543734001792	NAD(P) binding site [chemical binding]; other site
543734001793	putative active site [active]
543734001794	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
543734001795	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
543734001796	active site
543734001797	catalytic tetrad [active]
543734001798	putative transport protein YifK; Provisional; Region: PRK10746
543734001799	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
543734001800	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
543734001801	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
543734001802	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
543734001803	LytTr DNA-binding domain; Region: LytTR; smart00850
543734001804	Predicted membrane protein [Function unknown]; Region: COG1511
543734001805	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
543734001806	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734001807	Walker A/P-loop; other site
543734001808	ATP binding site [chemical binding]; other site
543734001809	Q-loop/lid; other site
543734001810	ABC transporter signature motif; other site
543734001811	Walker B; other site
543734001812	D-loop; other site
543734001813	H-loop/switch region; other site
543734001814	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
543734001815	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
543734001816	active site
543734001817	zinc binding site [ion binding]; other site
543734001818	hypothetical protein; Provisional; Region: PRK00967
543734001819	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
543734001820	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
543734001821	putative NAD(P) binding site [chemical binding]; other site
543734001822	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
543734001823	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
543734001824	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
543734001825	MgtC family; Region: MgtC; pfam02308
543734001826	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930
543734001827	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
543734001828	Rhomboid family; Region: Rhomboid; cl11446
543734001829	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
543734001830	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734001831	Walker A/P-loop; other site
543734001832	ATP binding site [chemical binding]; other site
543734001833	ABC transporter signature motif; other site
543734001834	Walker B; other site
543734001835	D-loop; other site
543734001836	H-loop/switch region; other site
543734001837	ABC transporter; Region: ABC_tran_2; pfam12848
543734001838	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
543734001839	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734001840	Walker A/P-loop; other site
543734001841	ATP binding site [chemical binding]; other site
543734001842	Q-loop/lid; other site
543734001843	ABC transporter signature motif; other site
543734001844	Walker B; other site
543734001845	D-loop; other site
543734001846	H-loop/switch region; other site
543734001847	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
543734001848	putative uracil binding site [chemical binding]; other site
543734001849	putative active site [active]
543734001850	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
543734001851	amphipathic channel; other site
543734001852	Asn-Pro-Ala signature motifs; other site
543734001853	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
543734001854	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
543734001855	glycerol kinase; Provisional; Region: glpK; PRK00047
543734001856	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
543734001857	N- and C-terminal domain interface [polypeptide binding]; other site
543734001858	active site
543734001859	MgATP binding site [chemical binding]; other site
543734001860	catalytic site [active]
543734001861	metal binding site [ion binding]; metal-binding site
543734001862	glycerol binding site [chemical binding]; other site
543734001863	homotetramer interface [polypeptide binding]; other site
543734001864	homodimer interface [polypeptide binding]; other site
543734001865	FBP binding site [chemical binding]; other site
543734001866	protein IIAGlc interface [polypeptide binding]; other site
543734001867	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
543734001868	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
543734001869	active site
543734001870	CAT RNA binding domain; Region: CAT_RBD; pfam03123
543734001871	transcriptional antiterminator BglG; Provisional; Region: PRK09772
543734001872	PRD domain; Region: PRD; pfam00874
543734001873	PRD domain; Region: PRD; pfam00874
543734001874	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
543734001875	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
543734001876	PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565
543734001877	active site
543734001878	P-loop; other site
543734001879	phosphorylation site [posttranslational modification]
543734001880	6-phospho-beta-galactosidase; Region: lacG; TIGR01233
543734001881	beta-galactosidase; Region: BGL; TIGR03356
543734001882	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
543734001883	methionine cluster; other site
543734001884	active site
543734001885	phosphorylation site [posttranslational modification]
543734001886	metal binding site [ion binding]; metal-binding site
543734001887	galactokinase; Provisional; Region: PRK05322
543734001888	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
543734001889	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
543734001890	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
543734001891	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
543734001892	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
543734001893	NAD binding site [chemical binding]; other site
543734001894	homodimer interface [polypeptide binding]; other site
543734001895	active site
543734001896	substrate binding site [chemical binding]; other site
543734001897	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
543734001898	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
543734001899	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
543734001900	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
543734001901	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
543734001902	DNA binding site [nucleotide binding]
543734001903	domain linker motif; other site
543734001904	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
543734001905	putative dimerization interface [polypeptide binding]; other site
543734001906	putative ligand binding site [chemical binding]; other site
543734001907	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
543734001908	active site
543734001909	catalytic residues [active]
543734001910	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
543734001911	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
543734001912	active site
543734001913	phosphorylation site [posttranslational modification]
543734001914	Phosphotransferase system, galactitol-specific IIB component [Carbohydrate transport and metabolism]; Region: SgaB; COG3414
543734001915	active site
543734001916	P-loop; other site
543734001917	phosphorylation site [posttranslational modification]
543734001918	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
543734001919	PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611
543734001920	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
543734001921	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
543734001922	putative substrate binding site [chemical binding]; other site
543734001923	putative ATP binding site [chemical binding]; other site
543734001924	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
543734001925	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
543734001926	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
543734001927	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
543734001928	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
543734001929	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
543734001930	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
543734001931	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734001932	motif II; other site
543734001933	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
543734001934	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
543734001935	active site
543734001936	metal binding site [ion binding]; metal-binding site
543734001937	DNA binding site [nucleotide binding]
543734001938	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
543734001939	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
543734001940	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
543734001941	Walker A/P-loop; other site
543734001942	ATP binding site [chemical binding]; other site
543734001943	Q-loop/lid; other site
543734001944	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734001945	ABC transporter signature motif; other site
543734001946	Walker B; other site
543734001947	D-loop; other site
543734001948	H-loop/switch region; other site
543734001949	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
543734001950	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
543734001951	putative dimer interface [polypeptide binding]; other site
543734001952	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
543734001953	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
543734001954	minor groove reading motif; other site
543734001955	helix-hairpin-helix signature motif; other site
543734001956	substrate binding pocket [chemical binding]; other site
543734001957	active site
543734001958	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
543734001959	DNA binding and oxoG recognition site [nucleotide binding]
543734001960	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
543734001961	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
543734001962	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
543734001963	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
543734001964	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
543734001965	dimer interface [polypeptide binding]; other site
543734001966	substrate binding site [chemical binding]; other site
543734001967	ATP binding site [chemical binding]; other site
543734001968	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
543734001969	NADH(P)-binding; Region: NAD_binding_10; pfam13460
543734001970	NAD binding site [chemical binding]; other site
543734001971	substrate binding site [chemical binding]; other site
543734001972	putative active site [active]
543734001973	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
543734001974	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
543734001975	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
543734001976	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
543734001977	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
543734001978	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
543734001979	zinc binding site [ion binding]; other site
543734001980	putative ligand binding site [chemical binding]; other site
543734001981	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
543734001982	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
543734001983	zinc binding site [ion binding]; other site
543734001984	putative ligand binding site [chemical binding]; other site
543734001985	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
543734001986	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
543734001987	TM-ABC transporter signature motif; other site
543734001988	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
543734001989	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734001990	Walker A/P-loop; other site
543734001991	ATP binding site [chemical binding]; other site
543734001992	Q-loop/lid; other site
543734001993	ABC transporter signature motif; other site
543734001994	Walker B; other site
543734001995	D-loop; other site
543734001996	H-loop/switch region; other site
543734001997	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
543734001998	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
543734001999	NADP binding site [chemical binding]; other site
543734002000	dimer interface [polypeptide binding]; other site
543734002001	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
543734002002	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
543734002003	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
543734002004	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
543734002005	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734002006	motif II; other site
543734002007	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
543734002008	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
543734002009	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
543734002010	Ligand binding site; other site
543734002011	Putative Catalytic site; other site
543734002012	DXD motif; other site
543734002013	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
543734002014	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
543734002015	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
543734002016	Predicted membrane protein [Function unknown]; Region: COG2246
543734002017	GtrA-like protein; Region: GtrA; pfam04138
543734002018	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
543734002019	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
543734002020	active site
543734002021	phosphorylation site [posttranslational modification]
543734002022	intermolecular recognition site; other site
543734002023	dimerization interface [polypeptide binding]; other site
543734002024	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
543734002025	DNA binding site [nucleotide binding]
543734002026	Di-sulfide bridge nucleocytoplasmic transport domain; Region: Brr6_like_C_C; cl12377
543734002027	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
543734002028	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
543734002029	dimer interface [polypeptide binding]; other site
543734002030	phosphorylation site [posttranslational modification]
543734002031	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
543734002032	ATP binding site [chemical binding]; other site
543734002033	Mg2+ binding site [ion binding]; other site
543734002034	G-X-G motif; other site
543734002035	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918
543734002036	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
543734002037	hypothetical protein; Provisional; Region: PRK06194
543734002038	classical (c) SDRs; Region: SDR_c; cd05233
543734002039	NAD(P) binding site [chemical binding]; other site
543734002040	active site
543734002041	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
543734002042	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
543734002043	dimer interface [polypeptide binding]; other site
543734002044	FMN binding site [chemical binding]; other site
543734002045	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
543734002046	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
543734002047	phosphate binding site [ion binding]; other site
543734002048	Predicted transcriptional regulators [Transcription]; Region: COG1695
543734002049	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
543734002050	Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083
543734002051	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
543734002052	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
543734002053	putative NAD(P) binding site [chemical binding]; other site
543734002054	dimer interface [polypeptide binding]; other site
543734002055	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
543734002056	Domain of unknown function DUF20; Region: UPF0118; pfam01594
543734002057	LexA repressor; Validated; Region: PRK00215
543734002058	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
543734002059	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
543734002060	Catalytic site [active]
543734002061	Membrane transport protein; Region: Mem_trans; pfam03547
543734002062	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
543734002063	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
543734002064	Uncharacterized conserved protein [Function unknown]; Region: COG3189
543734002065	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
543734002066	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
543734002067	Cl binding site [ion binding]; other site
543734002068	oligomer interface [polypeptide binding]; other site
543734002069	Transcriptional regulator [Transcription]; Region: LysR; COG0583
543734002070	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
543734002071	The substrate binding domain of LysR-type transcriptional regulator MleR which required for malolactic fermentation, contains type 2 periplasmic binidning fold; Region: PBP2_MleR; cd08437
543734002072	putative dimerization interface [polypeptide binding]; other site
543734002073	malate dehydrogenase; Provisional; Region: PRK13529
543734002074	Malic enzyme, N-terminal domain; Region: malic; pfam00390
543734002075	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
543734002076	NAD(P) binding site [chemical binding]; other site
543734002077	Membrane transport protein; Region: Mem_trans; pfam03547
543734002078	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
543734002079	dimer interface [polypeptide binding]; other site
543734002080	catalytic triad [active]
543734002081	peroxidatic and resolving cysteines [active]
543734002082	Flavodoxin domain; Region: Flavodoxin_5; cl17428
543734002083	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
543734002084	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734002085	non-specific DNA binding site [nucleotide binding]; other site
543734002086	salt bridge; other site
543734002087	sequence-specific DNA binding site [nucleotide binding]; other site
543734002088	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
543734002089	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
543734002090	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
543734002091	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
543734002092	Walker A/P-loop; other site
543734002093	ATP binding site [chemical binding]; other site
543734002094	Q-loop/lid; other site
543734002095	ABC transporter signature motif; other site
543734002096	Walker B; other site
543734002097	D-loop; other site
543734002098	H-loop/switch region; other site
543734002099	oligoendopeptidase F; Region: pepF; TIGR00181
543734002100	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609
543734002101	active site
543734002102	Zn binding site [ion binding]; other site
543734002103	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
543734002104	glucose-1-dehydrogenase; Provisional; Region: PRK06947
543734002105	NAD(P) binding site [chemical binding]; other site
543734002106	active site
543734002107	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
543734002108	active site
543734002109	multimer interface [polypeptide binding]; other site
543734002110	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
543734002111	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
543734002112	Soluble P-type ATPase [General function prediction only]; Region: COG4087
543734002113	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
543734002114	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
543734002115	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
543734002116	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
543734002117	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
543734002118	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734002119	motif II; other site
543734002120	Transcriptional regulators [Transcription]; Region: MarR; COG1846
543734002121	MarR family; Region: MarR_2; pfam12802
543734002122	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
543734002123	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
543734002124	flavoprotein NrdI; Provisional; Region: PRK02551
543734002125	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
543734002126	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
543734002127	active site
543734002128	catalytic tetrad [active]
543734002129	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
543734002130	Predicted membrane protein [Function unknown]; Region: COG2323
543734002131	Protein of unknown function (DUF3290); Region: DUF3290; pfam11694
543734002132	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
543734002133	substrate binding site [chemical binding]; other site
543734002134	THF binding site; other site
543734002135	zinc-binding site [ion binding]; other site
543734002136	S-ribosylhomocysteinase; Provisional; Region: PRK02260
543734002137	Uncharacterized conserved protein [Function unknown]; Region: COG0398
543734002138	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
543734002139	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
543734002140	RuvA N terminal domain; Region: RuvA_N; pfam01330
543734002141	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
543734002142	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
543734002143	Walker A motif; other site
543734002144	ATP binding site [chemical binding]; other site
543734002145	Walker B motif; other site
543734002146	arginine finger; other site
543734002147	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
543734002148	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
543734002149	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
543734002150	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
543734002151	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
543734002152	Preprotein translocase subunit; Region: YajC; pfam02699
543734002153	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
543734002154	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
543734002155	putative catalytic cysteine [active]
543734002156	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
543734002157	putative active site [active]
543734002158	metal binding site [ion binding]; metal-binding site
543734002159	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
543734002160	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
543734002161	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
543734002162	FeoA domain; Region: FeoA; pfam04023
543734002163	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
543734002164	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
543734002165	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
543734002166	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
543734002167	active site
543734002168	DNA polymerase IV; Validated; Region: PRK02406
543734002169	DNA binding site [nucleotide binding]
543734002170	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
543734002171	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
543734002172	DNA-binding site [nucleotide binding]; DNA binding site
543734002173	DRTGG domain; Region: DRTGG; pfam07085
543734002174	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
543734002175	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
543734002176	DHH family; Region: DHH; pfam01368
543734002177	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
543734002178	DEAD-like helicases superfamily; Region: DEXDc; smart00487
543734002179	ATP binding site [chemical binding]; other site
543734002180	Mg++ binding site [ion binding]; other site
543734002181	motif III; other site
543734002182	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
543734002183	nucleotide binding region [chemical binding]; other site
543734002184	ATP-binding site [chemical binding]; other site
543734002185	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
543734002186	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
543734002187	motif 1; other site
543734002188	active site
543734002189	motif 2; other site
543734002190	motif 3; other site
543734002191	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
543734002192	DHHA1 domain; Region: DHHA1; pfam02272
543734002193	hypothetical protein; Provisional; Region: PRK05473
543734002194	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
543734002195	hypothetical protein; Provisional; Region: PRK13678
543734002196	Cell division protein ZapA; Region: ZapA; pfam05164
543734002197	Colicin V production protein; Region: Colicin_V; pfam02674
543734002198	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
543734002199	MutS domain III; Region: MutS_III; pfam05192
543734002200	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734002201	Walker A/P-loop; other site
543734002202	ATP binding site [chemical binding]; other site
543734002203	Q-loop/lid; other site
543734002204	ABC transporter signature motif; other site
543734002205	Walker B; other site
543734002206	D-loop; other site
543734002207	H-loop/switch region; other site
543734002208	V-type ATP synthase subunit H; Validated; Region: PRK06397
543734002209	Smr domain; Region: Smr; pfam01713
543734002210	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
543734002211	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
543734002212	catalytic residues [active]
543734002213	D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734
543734002214	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
543734002215	acyl-activating enzyme (AAE) consensus motif; other site
543734002216	AMP binding site [chemical binding]; other site
543734002217	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
543734002218	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
543734002219	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
543734002220	DltD N-terminal region; Region: DltD_N; pfam04915
543734002221	DltD central region; Region: DltD_M; pfam04918
543734002222	DltD C-terminal region; Region: DltD_C; pfam04914
543734002223	Protein of unknown function (DUF2507); Region: DUF2507; pfam10702
543734002224	glutamate racemase; Provisional; Region: PRK00865
543734002225	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
543734002226	active site
543734002227	dimerization interface [polypeptide binding]; other site
543734002228	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
543734002229	active site
543734002230	metal binding site [ion binding]; metal-binding site
543734002231	homotetramer interface [polypeptide binding]; other site
543734002232	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
543734002233	amphipathic channel; other site
543734002234	Asn-Pro-Ala signature motifs; other site
543734002235	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
543734002236	FOG: CBS domain [General function prediction only]; Region: COG0517
543734002237	Domain of unknown function (DUF368); Region: DUF368; pfam04018
543734002238	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
543734002239	Mechanosensitive ion channel; Region: MS_channel; pfam00924
543734002240	Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103
543734002241	YtxH-like protein; Region: YtxH; pfam12732
543734002242	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
543734002243	HTH domain; Region: HTH_11; pfam08279
543734002244	3H domain; Region: 3H; pfam02829
543734002245	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
543734002246	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
543734002247	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
543734002248	active site
543734002249	catabolite control protein A; Region: ccpA; TIGR01481
543734002250	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
543734002251	DNA binding site [nucleotide binding]
543734002252	domain linker motif; other site
543734002253	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
543734002254	dimerization interface [polypeptide binding]; other site
543734002255	effector binding site; other site
543734002256	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
543734002257	Helix-turn-helix domain; Region: HTH_38; pfam13936
543734002258	Homeodomain-like domain; Region: HTH_32; pfam13565
543734002259	Integrase core domain; Region: rve; pfam00665
543734002260	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
543734002261	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
543734002262	Transglycosylase; Region: Transgly; pfam00912
543734002263	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
543734002264	hypothetical protein
543734002265	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
543734002266	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734002267	motif II; other site
543734002268	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
543734002269	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
543734002270	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
543734002271	dipeptidase PepV; Reviewed; Region: PRK07318
543734002272	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
543734002273	active site
543734002274	metal binding site [ion binding]; metal-binding site
543734002275	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
543734002276	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
543734002277	active site
543734002278	catalytic site [active]
543734002279	metal binding site [ion binding]; metal-binding site
543734002280	YibE/F-like protein; Region: YibE_F; pfam07907
543734002281	YibE/F-like protein; Region: YibE_F; pfam07907
543734002282	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
543734002283	putative active site [active]
543734002284	putative metal binding site [ion binding]; other site
543734002285	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
543734002286	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
543734002287	active site
543734002288	metal binding site [ion binding]; metal-binding site
543734002289	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
543734002290	Protein of unknown function (DUF1027); Region: DUF1027; pfam06265
543734002291	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
543734002292	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734002293	active site
543734002294	motif I; other site
543734002295	motif II; other site
543734002296	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734002297	Protein of unknown function (DUF1461); Region: DUF1461; pfam07314
543734002298	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
543734002299	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
543734002300	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
543734002301	tetramer interfaces [polypeptide binding]; other site
543734002302	binuclear metal-binding site [ion binding]; other site
543734002303	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
543734002304	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
543734002305	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
543734002306	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
543734002307	active site
543734002308	general stress protein 13; Validated; Region: PRK08059
543734002309	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
543734002310	RNA binding site [nucleotide binding]; other site
543734002311	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
543734002312	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
543734002313	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
543734002314	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
543734002315	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
543734002316	RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984
543734002317	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
543734002318	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
543734002319	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
543734002320	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
543734002321	putative ADP-binding pocket [chemical binding]; other site
543734002322	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
543734002323	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
543734002324	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
543734002325	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
543734002326	aromatic amino acid aminotransferase; Validated; Region: PRK07309
543734002327	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
543734002328	pyridoxal 5'-phosphate binding site [chemical binding]; other site
543734002329	homodimer interface [polypeptide binding]; other site
543734002330	catalytic residue [active]
543734002331	Protein of unknown function (DUF1797); Region: DUF1797; pfam08796
543734002332	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
543734002333	Sulfatase; Region: Sulfatase; pfam00884
543734002334	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
543734002335	metal binding site 2 [ion binding]; metal-binding site
543734002336	putative DNA binding helix; other site
543734002337	metal binding site 1 [ion binding]; metal-binding site
543734002338	dimer interface [polypeptide binding]; other site
543734002339	structural Zn2+ binding site [ion binding]; other site
543734002340	S-adenosylmethionine synthetase; Validated; Region: PRK05250
543734002341	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
543734002342	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
543734002343	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
543734002344	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
543734002345	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734002346	putative substrate translocation pore; other site
543734002347	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
543734002348	DNA binding residues [nucleotide binding]
543734002349	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
543734002350	putative dimer interface [polypeptide binding]; other site
543734002351	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734002352	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
543734002353	putative substrate translocation pore; other site
543734002354	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734002355	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
543734002356	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
543734002357	active site
543734002358	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
543734002359	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
543734002360	HIGH motif; other site
543734002361	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
543734002362	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
543734002363	active site
543734002364	KMSKS motif; other site
543734002365	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
543734002366	tRNA binding surface [nucleotide binding]; other site
543734002367	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
543734002368	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
543734002369	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
543734002370	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
543734002371	RNA binding surface [nucleotide binding]; other site
543734002372	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
543734002373	active site
543734002374	uracil binding [chemical binding]; other site
543734002375	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
543734002376	putative substrate binding site [chemical binding]; other site
543734002377	putative ATP binding site [chemical binding]; other site
543734002378	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
543734002379	nudix motif; other site
543734002380	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
543734002381	Int/Topo IB signature motif; other site
543734002382	Abi-like protein; Region: Abi_2; pfam07751
543734002383	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
543734002384	Domain of unknown function (DUF955); Region: DUF955; pfam06114
543734002385	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
543734002386	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734002387	non-specific DNA binding site [nucleotide binding]; other site
543734002388	salt bridge; other site
543734002389	sequence-specific DNA binding site [nucleotide binding]; other site
543734002390	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
543734002391	Domain of unknown function (DUF771); Region: DUF771; cl09962
543734002392	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
543734002393	RecT family; Region: RecT; cl04285
543734002394	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
543734002395	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734002396	non-specific DNA binding site [nucleotide binding]; other site
543734002397	salt bridge; other site
543734002398	sequence-specific DNA binding site [nucleotide binding]; other site
543734002399	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
543734002400	DNA-binding site [nucleotide binding]; DNA binding site
543734002401	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
543734002402	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
543734002403	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
543734002404	Walker A motif; other site
543734002405	ATP binding site [chemical binding]; other site
543734002406	Walker B motif; other site
543734002407	HNH endonuclease; Region: HNH_3; pfam13392
543734002408	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
543734002409	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
543734002410	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
543734002411	DNA binding residues [nucleotide binding]
543734002412	HNH endonuclease; Region: HNH; pfam01844
543734002413	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
543734002414	Phage-related protein [Function unknown]; Region: COG4695; cl01923
543734002415	Phage portal protein; Region: Phage_portal; pfam04860
543734002416	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
543734002417	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
543734002418	oligomer interface [polypeptide binding]; other site
543734002419	active site residues [active]
543734002420	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
543734002421	Phage capsid family; Region: Phage_capsid; pfam05065
543734002422	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
543734002423	oligomerization interface [polypeptide binding]; other site
543734002424	Phage head-tail joining protein; Region: Phage_H_T_join; cl11461
543734002425	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
543734002426	Tropomyosin like; Region: Tropomyosin_1; pfam12718
543734002427	tape measure domain; Region: tape_meas_nterm; TIGR02675
543734002428	Phage-related protein [Function unknown]; Region: COG5412
543734002429	Phage-related protein [Function unknown]; Region: COG4722
543734002430	Phage tail protein; Region: Sipho_tail; cl17486
543734002431	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
543734002432	Protein of unknown function (DUF1617); Region: DUF1617; pfam07761
543734002433	Bacteriophage holin; Region: Phage_holin_1; pfam04531
543734002434	Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382
543734002435	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
543734002436	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
543734002437	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
543734002438	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
543734002439	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
543734002440	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
543734002441	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
543734002442	catalytic residues [active]
543734002443	dimer interface [polypeptide binding]; other site
543734002444	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
543734002445	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
543734002446	pyridoxal 5'-phosphate binding site [chemical binding]; other site
543734002447	homodimer interface [polypeptide binding]; other site
543734002448	catalytic residue [active]
543734002449	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
543734002450	Helix-turn-helix domain; Region: HTH_38; pfam13936
543734002451	Integrase core domain; Region: rve; pfam00665
543734002452	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
543734002453	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
543734002454	active site
543734002455	metal binding site [ion binding]; metal-binding site
543734002456	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
543734002457	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
543734002458	Competence protein CoiA-like family; Region: CoiA; cl11541
543734002459	Thioredoxin; Region: Thioredoxin_5; pfam13743
543734002460	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
543734002461	putative active site [active]
543734002462	putative metal binding residues [ion binding]; other site
543734002463	signature motif; other site
543734002464	putative triphosphate binding site [ion binding]; other site
543734002465	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
543734002466	synthetase active site [active]
543734002467	NTP binding site [chemical binding]; other site
543734002468	metal binding site [ion binding]; metal-binding site
543734002469	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
543734002470	ATP-NAD kinase; Region: NAD_kinase; pfam01513
543734002471	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
543734002472	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
543734002473	RNA binding surface [nucleotide binding]; other site
543734002474	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
543734002475	active site
543734002476	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
543734002477	ApbE family; Region: ApbE; pfam02424
543734002478	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
543734002479	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
543734002480	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
543734002481	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829
543734002482	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
543734002483	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
543734002484	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
543734002485	active site
543734002486	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
543734002487	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
543734002488	Cl binding site [ion binding]; other site
543734002489	oligomer interface [polypeptide binding]; other site
543734002490	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
543734002491	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
543734002492	S-adenosylmethionine binding site [chemical binding]; other site
543734002493	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
543734002494	Protein of unknown function (DUF1149); Region: DUF1149; pfam06619
543734002495	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
543734002496	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
543734002497	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
543734002498	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
543734002499	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
543734002500	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
543734002501	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
543734002502	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
543734002503	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
543734002504	classical (c) SDRs; Region: SDR_c; cd05233
543734002505	NAD(P) binding site [chemical binding]; other site
543734002506	active site
543734002507	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
543734002508	Helix-turn-helix domain; Region: HTH_25; pfam13413
543734002509	non-specific DNA binding site [nucleotide binding]; other site
543734002510	salt bridge; other site
543734002511	sequence-specific DNA binding site [nucleotide binding]; other site
543734002512	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
543734002513	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
543734002514	competence damage-inducible protein A; Provisional; Region: PRK00549
543734002515	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
543734002516	putative MPT binding site; other site
543734002517	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
543734002518	recombinase A; Provisional; Region: recA; PRK09354
543734002519	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
543734002520	hexamer interface [polypeptide binding]; other site
543734002521	Walker A motif; other site
543734002522	ATP binding site [chemical binding]; other site
543734002523	Walker B motif; other site
543734002524	ribonuclease Y; Region: RNase_Y; TIGR03319
543734002525	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
543734002526	Zn2+ binding site [ion binding]; other site
543734002527	Mg2+ binding site [ion binding]; other site
543734002528	Uncharacterized conserved protein [Function unknown]; Region: COG1739
543734002529	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
543734002530	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
543734002531	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
543734002532	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
543734002533	ATP binding site [chemical binding]; other site
543734002534	putative Mg++ binding site [ion binding]; other site
543734002535	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
543734002536	nucleotide binding region [chemical binding]; other site
543734002537	ATP-binding site [chemical binding]; other site
543734002538	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
543734002539	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
543734002540	active site
543734002541	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
543734002542	30S subunit binding site; other site
543734002543	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906
543734002544	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
543734002545	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
543734002546	nucleotide binding region [chemical binding]; other site
543734002547	ATP-binding site [chemical binding]; other site
543734002548	hypothetical protein
543734002549	peptide chain release factor 2; Provisional; Region: PRK05589
543734002550	PCRF domain; Region: PCRF; pfam03462
543734002551	RF-1 domain; Region: RF-1; pfam00472
543734002552	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
543734002553	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734002554	Walker A/P-loop; other site
543734002555	ATP binding site [chemical binding]; other site
543734002556	Q-loop/lid; other site
543734002557	ABC transporter signature motif; other site
543734002558	Walker B; other site
543734002559	D-loop; other site
543734002560	H-loop/switch region; other site
543734002561	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
543734002562	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
543734002563	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
543734002564	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
543734002565	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
543734002566	active site
543734002567	phosphorylation site [posttranslational modification]
543734002568	intermolecular recognition site; other site
543734002569	dimerization interface [polypeptide binding]; other site
543734002570	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
543734002571	DNA binding site [nucleotide binding]
543734002572	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
543734002573	PAS domain; Region: PAS_8; pfam13188
543734002574	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
543734002575	dimer interface [polypeptide binding]; other site
543734002576	phosphorylation site [posttranslational modification]
543734002577	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
543734002578	ATP binding site [chemical binding]; other site
543734002579	Mg2+ binding site [ion binding]; other site
543734002580	G-X-G motif; other site
543734002581	phosphate binding protein; Region: ptsS_2; TIGR02136
543734002582	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
543734002583	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
543734002584	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734002585	dimer interface [polypeptide binding]; other site
543734002586	conserved gate region; other site
543734002587	putative PBP binding loops; other site
543734002588	ABC-ATPase subunit interface; other site
543734002589	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
543734002590	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734002591	dimer interface [polypeptide binding]; other site
543734002592	conserved gate region; other site
543734002593	putative PBP binding loops; other site
543734002594	ABC-ATPase subunit interface; other site
543734002595	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
543734002596	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
543734002597	Walker A/P-loop; other site
543734002598	ATP binding site [chemical binding]; other site
543734002599	Q-loop/lid; other site
543734002600	ABC transporter signature motif; other site
543734002601	Walker B; other site
543734002602	D-loop; other site
543734002603	H-loop/switch region; other site
543734002604	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14255
543734002605	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
543734002606	Walker A/P-loop; other site
543734002607	ATP binding site [chemical binding]; other site
543734002608	Q-loop/lid; other site
543734002609	ABC transporter signature motif; other site
543734002610	Walker B; other site
543734002611	D-loop; other site
543734002612	H-loop/switch region; other site
543734002613	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
543734002614	PhoU domain; Region: PhoU; pfam01895
543734002615	PhoU domain; Region: PhoU; pfam01895
543734002616	Uncharacterized conserved protein [Function unknown]; Region: COG3595
543734002617	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
543734002618	Membrane protein of unknown function; Region: DUF360; pfam04020
543734002619	HPr kinase/phosphorylase; Provisional; Region: PRK05428
543734002620	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
543734002621	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
543734002622	Hpr binding site; other site
543734002623	active site
543734002624	homohexamer subunit interaction site [polypeptide binding]; other site
543734002625	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
543734002626	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
543734002627	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
543734002628	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
543734002629	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
543734002630	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
543734002631	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
543734002632	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
543734002633	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
543734002634	active site
543734002635	substrate binding site [chemical binding]; other site
543734002636	metal binding site [ion binding]; metal-binding site
543734002637	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
543734002638	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
543734002639	active site
543734002640	phosphorylation site [posttranslational modification]
543734002641	intermolecular recognition site; other site
543734002642	dimerization interface [polypeptide binding]; other site
543734002643	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
543734002644	DNA binding site [nucleotide binding]
543734002645	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
543734002646	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
543734002647	dimer interface [polypeptide binding]; other site
543734002648	phosphorylation site [posttranslational modification]
543734002649	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
543734002650	ATP binding site [chemical binding]; other site
543734002651	Mg2+ binding site [ion binding]; other site
543734002652	G-X-G motif; other site
543734002653	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734002654	Walker A/P-loop; other site
543734002655	ATP binding site [chemical binding]; other site
543734002656	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
543734002657	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
543734002658	Q-loop/lid; other site
543734002659	ABC transporter signature motif; other site
543734002660	Walker B; other site
543734002661	D-loop; other site
543734002662	H-loop/switch region; other site
543734002663	FtsX-like permease family; Region: FtsX; pfam02687
543734002664	HD domain; Region: HD_3; cl17350
543734002665	excinuclease ABC subunit B; Provisional; Region: PRK05298
543734002666	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
543734002667	ATP binding site [chemical binding]; other site
543734002668	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
543734002669	nucleotide binding region [chemical binding]; other site
543734002670	ATP-binding site [chemical binding]; other site
543734002671	Ultra-violet resistance protein B; Region: UvrB; pfam12344
543734002672	UvrB/uvrC motif; Region: UVR; pfam02151
543734002673	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
543734002674	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
543734002675	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
543734002676	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
543734002677	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
543734002678	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
543734002679	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
543734002680	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
543734002681	phosphate binding site [ion binding]; other site
543734002682	putative substrate binding pocket [chemical binding]; other site
543734002683	dimer interface [polypeptide binding]; other site
543734002684	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
543734002685	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
543734002686	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
543734002687	MarR family; Region: MarR; pfam01047
543734002688	Clp protease; Region: CLP_protease; pfam00574
543734002689	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
543734002690	oligomer interface [polypeptide binding]; other site
543734002691	active site residues [active]
543734002692	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
543734002693	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
543734002694	Int/Topo IB signature motif; other site
543734002695	Ion transport protein; Region: Ion_trans; pfam00520
543734002696	Ion channel; Region: Ion_trans_2; pfam07885
543734002697	Short C-terminal domain; Region: SHOCT; pfam09851
543734002698	Domain of unknown function (DUF955); Region: DUF955; cl01076
543734002699	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
543734002700	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734002701	non-specific DNA binding site [nucleotide binding]; other site
543734002702	salt bridge; other site
543734002703	sequence-specific DNA binding site [nucleotide binding]; other site
543734002704	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
543734002705	sequence-specific DNA binding site [nucleotide binding]; other site
543734002706	salt bridge; other site
543734002707	ORF6N domain; Region: ORF6N; pfam10543
543734002708	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
543734002709	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
543734002710	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
543734002711	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
543734002712	ATP binding site [chemical binding]; other site
543734002713	putative Mg++ binding site [ion binding]; other site
543734002714	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
543734002715	nucleotide binding region [chemical binding]; other site
543734002716	ATP-binding site [chemical binding]; other site
543734002717	AAA domain; Region: AAA_24; pfam13479
543734002718	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
543734002719	polymerase nucleotide-binding site; other site
543734002720	DNA-binding residues [nucleotide binding]; DNA binding site
543734002721	nucleotide binding site [chemical binding]; other site
543734002722	primase nucleotide-binding site [nucleotide binding]; other site
543734002723	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
543734002724	Virulence-associated protein E; Region: VirE; pfam05272
543734002725	VRR-NUC domain; Region: VRR_NUC; pfam08774
543734002726	HNH endonuclease; Region: HNH_3; pfam13392
543734002727	phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636
543734002728	HNH endonuclease; Region: HNH; pfam01844
543734002729	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
543734002730	Phage-related protein [Function unknown]; Region: COG4695; cl01923
543734002731	Phage portal protein; Region: Phage_portal; pfam04860
543734002732	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
543734002733	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
543734002734	oligomer interface [polypeptide binding]; other site
543734002735	active site residues [active]
543734002736	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
543734002737	Phage capsid family; Region: Phage_capsid; pfam05065
543734002738	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
543734002739	oligomerization interface [polypeptide binding]; other site
543734002740	Phage head-tail joining protein; Region: Phage_H_T_join; cl11461
543734002741	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
543734002742	Phage-related minor tail protein [Function unknown]; Region: COG5280
543734002743	Phage-related protein [Function unknown]; Region: COG5412
543734002744	Phage-related protein [Function unknown]; Region: COG4722
543734002745	Phage tail protein; Region: Sipho_tail; cl17486
543734002746	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
543734002747	Protein of unknown function (DUF1617); Region: DUF1617; pfam07761
543734002748	Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890
543734002749	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
543734002750	amidase catalytic site [active]
543734002751	Zn binding residues [ion binding]; other site
543734002752	substrate binding site [chemical binding]; other site
543734002753	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
543734002754	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
543734002755	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
543734002756	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
543734002757	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
543734002758	Phosphoglycerate kinase; Region: PGK; pfam00162
543734002759	substrate binding site [chemical binding]; other site
543734002760	hinge regions; other site
543734002761	ADP binding site [chemical binding]; other site
543734002762	catalytic site [active]
543734002763	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
543734002764	triosephosphate isomerase; Provisional; Region: PRK14567
543734002765	substrate binding site [chemical binding]; other site
543734002766	dimer interface [polypeptide binding]; other site
543734002767	catalytic triad [active]
543734002768	enolase; Provisional; Region: eno; PRK00077
543734002769	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
543734002770	dimer interface [polypeptide binding]; other site
543734002771	metal binding site [ion binding]; metal-binding site
543734002772	substrate binding pocket [chemical binding]; other site
543734002773	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734002774	H+ Antiporter protein; Region: 2A0121; TIGR00900
543734002775	putative substrate translocation pore; other site
543734002776	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
543734002777	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
543734002778	Cl- selectivity filter; other site
543734002779	Cl- binding residues [ion binding]; other site
543734002780	pore gating glutamate residue; other site
543734002781	dimer interface [polypeptide binding]; other site
543734002782	H+/Cl- coupling transport residue; other site
543734002783	TrkA-C domain; Region: TrkA_C; pfam02080
543734002784	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
543734002785	Esterase/lipase [General function prediction only]; Region: COG1647
543734002786	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
543734002787	ribonuclease R; Region: RNase_R; TIGR02063
543734002788	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
543734002789	RNB domain; Region: RNB; pfam00773
543734002790	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
543734002791	RNA binding site [nucleotide binding]; other site
543734002792	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
543734002793	SmpB-tmRNA interface; other site
543734002794	Transcriptional regulators [Transcription]; Region: PurR; COG1609
543734002795	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
543734002796	DNA binding site [nucleotide binding]
543734002797	domain linker motif; other site
543734002798	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
543734002799	ligand binding site [chemical binding]; other site
543734002800	dimerization interface [polypeptide binding]; other site
543734002801	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
543734002802	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
543734002803	Ca binding site [ion binding]; other site
543734002804	active site
543734002805	catalytic site [active]
543734002806	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
543734002807	homodimer interface [polypeptide binding]; other site
543734002808	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
543734002809	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
543734002810	active site
543734002811	homodimer interface [polypeptide binding]; other site
543734002812	catalytic site [active]
543734002813	maltose phosphorylase; Provisional; Region: PRK13807
543734002814	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
543734002815	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
543734002816	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
543734002817	beta-phosphoglucomutase; Region: bPGM; TIGR01990
543734002818	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734002819	motif II; other site
543734002820	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
543734002821	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
543734002822	Walker A/P-loop; other site
543734002823	ATP binding site [chemical binding]; other site
543734002824	Q-loop/lid; other site
543734002825	ABC transporter signature motif; other site
543734002826	Walker B; other site
543734002827	D-loop; other site
543734002828	H-loop/switch region; other site
543734002829	TOBE domain; Region: TOBE_2; pfam08402
543734002830	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
543734002831	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
543734002832	Ca binding site [ion binding]; other site
543734002833	active site
543734002834	catalytic site [active]
543734002835	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
543734002836	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
543734002837	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
543734002838	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734002839	dimer interface [polypeptide binding]; other site
543734002840	conserved gate region; other site
543734002841	putative PBP binding loops; other site
543734002842	ABC-ATPase subunit interface; other site
543734002843	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
543734002844	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734002845	dimer interface [polypeptide binding]; other site
543734002846	conserved gate region; other site
543734002847	ABC-ATPase subunit interface; other site
543734002848	ATP synthase regulation protein NCA2; Region: NCA2; pfam08637
543734002849	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
543734002850	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734002851	non-specific DNA binding site [nucleotide binding]; other site
543734002852	salt bridge; other site
543734002853	sequence-specific DNA binding site [nucleotide binding]; other site
543734002854	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
543734002855	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
543734002856	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
543734002857	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
543734002858	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
543734002859	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
543734002860	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734002861	dimer interface [polypeptide binding]; other site
543734002862	conserved gate region; other site
543734002863	putative PBP binding loops; other site
543734002864	ABC-ATPase subunit interface; other site
543734002865	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734002866	dimer interface [polypeptide binding]; other site
543734002867	conserved gate region; other site
543734002868	putative PBP binding loops; other site
543734002869	ABC-ATPase subunit interface; other site
543734002870	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
543734002871	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734002872	Walker A/P-loop; other site
543734002873	ATP binding site [chemical binding]; other site
543734002874	Q-loop/lid; other site
543734002875	ABC transporter signature motif; other site
543734002876	Walker B; other site
543734002877	D-loop; other site
543734002878	H-loop/switch region; other site
543734002879	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
543734002880	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
543734002881	Coenzyme A binding pocket [chemical binding]; other site
543734002882	Tubby C 2; Region: Tub_2; cl02043
543734002883	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734002884	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
543734002885	active site
543734002886	motif I; other site
543734002887	motif II; other site
543734002888	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
543734002889	ligand binding site [chemical binding]; other site
543734002890	active site
543734002891	UGI interface [polypeptide binding]; other site
543734002892	catalytic site [active]
543734002893	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
543734002894	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
543734002895	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
543734002896	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734002897	Walker A/P-loop; other site
543734002898	ATP binding site [chemical binding]; other site
543734002899	Q-loop/lid; other site
543734002900	ABC transporter signature motif; other site
543734002901	Walker B; other site
543734002902	D-loop; other site
543734002903	H-loop/switch region; other site
543734002904	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
543734002905	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
543734002906	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
543734002907	active site
543734002908	catalytic site [active]
543734002909	substrate binding site [chemical binding]; other site
543734002910	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
543734002911	active site
543734002912	putative catalytic site [active]
543734002913	DNA binding site [nucleotide binding]
543734002914	putative phosphate binding site [ion binding]; other site
543734002915	metal binding site A [ion binding]; metal-binding site
543734002916	AP binding site [nucleotide binding]; other site
543734002917	metal binding site B [ion binding]; metal-binding site
543734002918	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
543734002919	FAD binding domain; Region: FAD_binding_4; pfam01565
543734002920	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
543734002921	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
543734002922	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
543734002923	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
543734002924	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734002925	non-specific DNA binding site [nucleotide binding]; other site
543734002926	salt bridge; other site
543734002927	sequence-specific DNA binding site [nucleotide binding]; other site
543734002928	Cupin domain; Region: Cupin_2; pfam07883
543734002929	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
543734002930	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
543734002931	Walker A/P-loop; other site
543734002932	ATP binding site [chemical binding]; other site
543734002933	Q-loop/lid; other site
543734002934	ABC transporter signature motif; other site
543734002935	Walker B; other site
543734002936	D-loop; other site
543734002937	H-loop/switch region; other site
543734002938	TOBE domain; Region: TOBE_2; pfam08402
543734002939	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
543734002940	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734002941	dimer interface [polypeptide binding]; other site
543734002942	conserved gate region; other site
543734002943	putative PBP binding loops; other site
543734002944	ABC-ATPase subunit interface; other site
543734002945	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
543734002946	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734002947	dimer interface [polypeptide binding]; other site
543734002948	conserved gate region; other site
543734002949	putative PBP binding loops; other site
543734002950	ABC-ATPase subunit interface; other site
543734002951	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
543734002952	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
543734002953	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
543734002954	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
543734002955	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
543734002956	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
543734002957	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734002958	motif II; other site
543734002959	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
543734002960	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
543734002961	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
543734002962	PXA domain; Region: PXA; cl02564
543734002963	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
543734002964	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
543734002965	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
543734002966	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
543734002967	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
543734002968	Walker A/P-loop; other site
543734002969	ATP binding site [chemical binding]; other site
543734002970	Q-loop/lid; other site
543734002971	ABC transporter signature motif; other site
543734002972	Walker B; other site
543734002973	D-loop; other site
543734002974	H-loop/switch region; other site
543734002975	Uncharacterized conserved protein [Function unknown]; Region: COG1624
543734002976	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
543734002977	YbbR-like protein; Region: YbbR; pfam07949
543734002978	YbbR-like protein; Region: YbbR; pfam07949
543734002979	YbbR-like protein; Region: YbbR; pfam07949
543734002980	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
543734002981	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
543734002982	active site
543734002983	substrate binding site [chemical binding]; other site
543734002984	metal binding site [ion binding]; metal-binding site
543734002985	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
543734002986	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
543734002987	glutaminase active site [active]
543734002988	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
543734002989	dimer interface [polypeptide binding]; other site
543734002990	active site
543734002991	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
543734002992	dimer interface [polypeptide binding]; other site
543734002993	active site
543734002994	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
543734002995	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
543734002996	active site
543734002997	Zn binding site [ion binding]; other site
543734002998	hypothetical protein; Validated; Region: PRK00110
543734002999	Type II/IV secretion system protein; Region: T2SE; pfam00437
543734003000	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
543734003001	Walker A motif; other site
543734003002	ATP binding site [chemical binding]; other site
543734003003	Walker B motif; other site
543734003004	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
543734003005	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
543734003006	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
543734003007	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
543734003008	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
543734003009	S-adenosylmethionine binding site [chemical binding]; other site
543734003010	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
543734003011	Spore germination protein; Region: Spore_permease; cl17796
543734003012	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
543734003013	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
543734003014	putative acyl-acceptor binding pocket; other site
543734003015	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
543734003016	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
543734003017	Ligand binding site; other site
543734003018	metal-binding site
543734003019	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
543734003020	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
543734003021	Ligand binding site; other site
543734003022	metal-binding site
543734003023	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
543734003024	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
543734003025	putative acyl-acceptor binding pocket; other site
543734003026	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
543734003027	Melibiase; Region: Melibiase; pfam02065
543734003028	5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739
543734003029	SdpI/YhfL protein family; Region: SdpI; pfam13630
543734003030	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
543734003031	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
543734003032	active site
543734003033	phosphorylation site [posttranslational modification]
543734003034	intermolecular recognition site; other site
543734003035	dimerization interface [polypeptide binding]; other site
543734003036	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
543734003037	DNA binding site [nucleotide binding]
543734003038	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
543734003039	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
543734003040	dimerization interface [polypeptide binding]; other site
543734003041	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
543734003042	dimer interface [polypeptide binding]; other site
543734003043	phosphorylation site [posttranslational modification]
543734003044	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
543734003045	ATP binding site [chemical binding]; other site
543734003046	Mg2+ binding site [ion binding]; other site
543734003047	G-X-G motif; other site
543734003048	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
543734003049	Predicted acetyltransferase [General function prediction only]; Region: COG3153
543734003050	hypothetical protein; Provisional; Region: PRK04435
543734003051	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
543734003052	DNA-binding interface [nucleotide binding]; DNA binding site
543734003053	C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888
543734003054	DNA polymerase IV; Reviewed; Region: PRK03103
543734003055	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
543734003056	active site
543734003057	DNA binding site [nucleotide binding]
543734003058	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
543734003059	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
543734003060	Double zinc ribbon; Region: DZR; pfam12773
543734003061	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
543734003062	active site
543734003063	catalytic triad [active]
543734003064	oxyanion hole [active]
543734003065	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
543734003066	Part of AAA domain; Region: AAA_19; pfam13245
543734003067	Family description; Region: UvrD_C_2; pfam13538
543734003068	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
543734003069	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
543734003070	nucleotide binding pocket [chemical binding]; other site
543734003071	K-X-D-G motif; other site
543734003072	catalytic site [active]
543734003073	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
543734003074	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
543734003075	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
543734003076	Dimer interface [polypeptide binding]; other site
543734003077	BRCT sequence motif; other site
543734003078	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
543734003079	putative dimer interface [polypeptide binding]; other site
543734003080	CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537
543734003081	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
543734003082	putative dimer interface [polypeptide binding]; other site
543734003083	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
543734003084	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
543734003085	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
543734003086	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
543734003087	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
543734003088	GatB domain; Region: GatB_Yqey; smart00845
543734003089	putative lipid kinase; Reviewed; Region: PRK13055
543734003090	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
543734003091	TRAM domain; Region: TRAM; pfam01938
543734003092	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
543734003093	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
543734003094	S-adenosylmethionine binding site [chemical binding]; other site
543734003095	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734003096	Major Facilitator Superfamily; Region: MFS_1; pfam07690
543734003097	putative substrate translocation pore; other site
543734003098	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734003099	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
543734003100	active site
543734003101	motif I; other site
543734003102	motif II; other site
543734003103	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
543734003104	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
543734003105	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
543734003106	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
543734003107	active site
543734003108	Zn binding site [ion binding]; other site
543734003109	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734003110	Major Facilitator Superfamily; Region: MFS_1; pfam07690
543734003111	putative substrate translocation pore; other site
543734003112	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
543734003113	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
543734003114	Coenzyme A binding pocket [chemical binding]; other site
543734003115	EDD domain protein, DegV family; Region: DegV; TIGR00762
543734003116	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
543734003117	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
543734003118	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
543734003119	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419
543734003120	active site
543734003121	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
543734003122	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
543734003123	formate dehydrogenase; Provisional; Region: PRK07574
543734003124	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
543734003125	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
543734003126	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
543734003127	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
543734003128	ATP binding site [chemical binding]; other site
543734003129	putative Mg++ binding site [ion binding]; other site
543734003130	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
543734003131	nucleotide binding region [chemical binding]; other site
543734003132	ATP-binding site [chemical binding]; other site
543734003133	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166
543734003134	active site
543734003135	methionine cluster; other site
543734003136	phosphorylation site [posttranslational modification]
543734003137	metal binding site [ion binding]; metal-binding site
543734003138	Domain of unknown function (DUF3284); Region: DUF3284; pfam11687
543734003139	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
543734003140	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
543734003141	ATP binding site [chemical binding]; other site
543734003142	putative Mg++ binding site [ion binding]; other site
543734003143	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
543734003144	nucleotide binding region [chemical binding]; other site
543734003145	ATP-binding site [chemical binding]; other site
543734003146	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
543734003147	HRDC domain; Region: HRDC; pfam00570
543734003148	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
543734003149	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
543734003150	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
543734003151	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
543734003152	WHG domain; Region: WHG; pfam13305
543734003153	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
543734003154	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
543734003155	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
543734003156	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
543734003157	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
543734003158	active site
543734003159	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
543734003160	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
543734003161	active site
543734003162	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
543734003163	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
543734003164	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
543734003165	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
543734003166	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
543734003167	active site
543734003168	tetramer interface; other site
543734003169	putative transposase OrfB; Reviewed; Region: PHA02517
543734003170	HTH-like domain; Region: HTH_21; pfam13276
543734003171	Integrase core domain; Region: rve; pfam00665
543734003172	Integrase core domain; Region: rve_3; pfam13683
543734003173	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
543734003174	Homeodomain-like domain; Region: HTH_23; cl17451
543734003175	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
543734003176	Transposase; Region: HTH_Tnp_1; cl17663
543734003177	Helix-turn-helix domain; Region: HTH_28; pfam13518
543734003178	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
543734003179	active site
543734003180	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
543734003181	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
543734003182	NAD(P) binding site [chemical binding]; other site
543734003183	active site
543734003184	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
543734003185	Helix-turn-helix domain; Region: HTH_38; pfam13936
543734003186	Integrase core domain; Region: rve; pfam00665
543734003187	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
543734003188	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
543734003189	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
543734003190	beta-galactosidase; Region: BGL; TIGR03356
543734003191	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
543734003192	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
543734003193	active site turn [active]
543734003194	phosphorylation site [posttranslational modification]
543734003195	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
543734003196	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
543734003197	HPr interaction site; other site
543734003198	glycerol kinase (GK) interaction site [polypeptide binding]; other site
543734003199	active site
543734003200	phosphorylation site [posttranslational modification]
543734003201	transcriptional antiterminator BglG; Provisional; Region: PRK09772
543734003202	CAT RNA binding domain; Region: CAT_RBD; smart01061
543734003203	PRD domain; Region: PRD; pfam00874
543734003204	PRD domain; Region: PRD; pfam00874
543734003205	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
543734003206	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
543734003207	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
543734003208	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
543734003209	Ligand binding site; other site
543734003210	Putative Catalytic site; other site
543734003211	DXD motif; other site
543734003212	Predicted membrane protein [Function unknown]; Region: COG4129
543734003213	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
543734003214	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
543734003215	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
543734003216	DNA-binding site [nucleotide binding]; DNA binding site
543734003217	RNA-binding motif; other site
543734003218	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
543734003219	Coenzyme A binding pocket [chemical binding]; other site
543734003220	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
543734003221	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
543734003222	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
543734003223	active site
543734003224	xanthine permease; Region: pbuX; TIGR03173
543734003225	ATP-grasp domain; Region: ATP-grasp_4; cl17255
543734003226	adenylosuccinate lyase; Provisional; Region: PRK07492
543734003227	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
543734003228	tetramer interface [polypeptide binding]; other site
543734003229	active site
543734003230	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
543734003231	Sulfatase; Region: Sulfatase; pfam00884
543734003232	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
543734003233	Sugar transport protein; Region: Sugar_transport; pfam06800
543734003234	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
543734003235	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
543734003236	active site
543734003237	dimer interface [polypeptide binding]; other site
543734003238	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
543734003239	dimer interface [polypeptide binding]; other site
543734003240	active site
543734003241	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
543734003242	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
543734003243	Int/Topo IB signature motif; other site
543734003244	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
543734003245	Domain of unknown function (DUF4041); Region: DUF4041; pfam13250
543734003246	This entry represents the putative helicase A859L; Region: T5orf172; smart00974
543734003247	Domain of unknown function (DUF955); Region: DUF955; cl01076
543734003248	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
543734003249	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734003250	non-specific DNA binding site [nucleotide binding]; other site
543734003251	salt bridge; other site
543734003252	sequence-specific DNA binding site [nucleotide binding]; other site
543734003253	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
543734003254	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734003255	non-specific DNA binding site [nucleotide binding]; other site
543734003256	salt bridge; other site
543734003257	sequence-specific DNA binding site [nucleotide binding]; other site
543734003258	Thylakoid formation protein; Region: ThylakoidFormat; cl12138
543734003259	RecT family; Region: RecT; cl04285
543734003260	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
543734003261	Helix-turn-helix domain; Region: HTH_36; pfam13730
543734003262	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
543734003263	Hypothetical protein (DUF2513); Region: DUF2513; pfam10711
543734003264	hypothetical protein
543734003265	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734003266	non-specific DNA binding site [nucleotide binding]; other site
543734003267	salt bridge; other site
543734003268	sequence-specific DNA binding site [nucleotide binding]; other site
543734003269	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
543734003270	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
543734003271	GcrA cell cycle regulator; Region: GcrA; cl11564
543734003272	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
543734003273	Terminase small subunit; Region: Terminase_2; pfam03592
543734003274	Phage terminase large subunit; Region: Terminase_3; cl12054
543734003275	Terminase-like family; Region: Terminase_6; pfam03237
543734003276	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
543734003277	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
543734003278	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
543734003279	Domain of unknown function (DUF4355); Region: DUF4355; pfam14265
543734003280	hypothetical protein
543734003281	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
543734003282	Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135
543734003283	Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883
543734003284	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
543734003285	Phage major tail protein 2; Region: Phage_tail_2; pfam06199
543734003286	Phage protein; Region: DUF3647; pfam12363
543734003287	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
543734003288	Phage-related protein [Function unknown]; Region: COG5412
543734003289	Phage tail protein; Region: Sipho_tail; pfam05709
543734003290	Phage tail protein; Region: Sipho_tail; cl17486
543734003291	Phage tail protein; Region: Sipho_tail; cl17486
543734003292	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
543734003293	Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900
543734003294	Bacteriophage holin; Region: Phage_holin_1; pfam04531
543734003295	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
543734003296	active site
543734003297	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
543734003298	Bacterial SH3 domain; Region: SH3_5; pfam08460
543734003299	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
543734003300	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
543734003301	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
543734003302	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
543734003303	Uncharacterized conserved protein [Function unknown]; Region: COG1359
543734003304	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930
543734003305	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
543734003306	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
543734003307	Helix-turn-helix domain; Region: HTH_38; pfam13936
543734003308	Integrase core domain; Region: rve; pfam00665
543734003309	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
543734003310	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
543734003311	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
543734003312	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
543734003313	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
543734003314	nucleoside/Zn binding site; other site
543734003315	dimer interface [polypeptide binding]; other site
543734003316	catalytic motif [active]
543734003317	TspO/MBR family; Region: TspO_MBR; pfam03073
543734003318	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734003319	Major Facilitator Superfamily; Region: MFS_1; pfam07690
543734003320	putative substrate translocation pore; other site
543734003321	Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
543734003322	Peptidase family C69; Region: Peptidase_C69; pfam03577
543734003323	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
543734003324	catalytic core [active]
543734003325	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
543734003326	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
543734003327	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
543734003328	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
543734003329	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
543734003330	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734003331	Walker A/P-loop; other site
543734003332	ATP binding site [chemical binding]; other site
543734003333	Q-loop/lid; other site
543734003334	ABC transporter signature motif; other site
543734003335	Walker B; other site
543734003336	D-loop; other site
543734003337	H-loop/switch region; other site
543734003338	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
543734003339	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
543734003340	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
543734003341	Walker A/P-loop; other site
543734003342	ATP binding site [chemical binding]; other site
543734003343	Q-loop/lid; other site
543734003344	ABC transporter signature motif; other site
543734003345	Walker B; other site
543734003346	D-loop; other site
543734003347	H-loop/switch region; other site
543734003348	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
543734003349	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
543734003350	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
543734003351	putative metal binding site [ion binding]; other site
543734003352	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
543734003353	active site
543734003354	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
543734003355	Beta-lactamase; Region: Beta-lactamase; pfam00144
543734003356	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
543734003357	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
543734003358	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
543734003359	thymidine kinase; Provisional; Region: PRK04296
543734003360	peptide chain release factor 1; Validated; Region: prfA; PRK00591
543734003361	This domain is found in peptide chain release factors; Region: PCRF; smart00937
543734003362	RF-1 domain; Region: RF-1; pfam00472
543734003363	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
543734003364	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
543734003365	S-adenosylmethionine binding site [chemical binding]; other site
543734003366	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
543734003367	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
543734003368	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
543734003369	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
543734003370	dimer interface [polypeptide binding]; other site
543734003371	active site
543734003372	glycine-pyridoxal phosphate binding site [chemical binding]; other site
543734003373	folate binding site [chemical binding]; other site
543734003374	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
543734003375	active site
543734003376	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
543734003377	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
543734003378	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
543734003379	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
543734003380	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
543734003381	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
543734003382	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
543734003383	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
543734003384	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
543734003385	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
543734003386	beta subunit interaction interface [polypeptide binding]; other site
543734003387	Walker A motif; other site
543734003388	ATP binding site [chemical binding]; other site
543734003389	Walker B motif; other site
543734003390	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
543734003391	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
543734003392	core domain interface [polypeptide binding]; other site
543734003393	delta subunit interface [polypeptide binding]; other site
543734003394	epsilon subunit interface [polypeptide binding]; other site
543734003395	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
543734003396	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
543734003397	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
543734003398	alpha subunit interaction interface [polypeptide binding]; other site
543734003399	Walker A motif; other site
543734003400	ATP binding site [chemical binding]; other site
543734003401	Walker B motif; other site
543734003402	inhibitor binding site; inhibition site
543734003403	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
543734003404	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
543734003405	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
543734003406	gamma subunit interface [polypeptide binding]; other site
543734003407	epsilon subunit interface [polypeptide binding]; other site
543734003408	LBP interface [polypeptide binding]; other site
543734003409	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
543734003410	rod shape-determining protein MreB; Provisional; Region: PRK13930
543734003411	MreB and similar proteins; Region: MreB_like; cd10225
543734003412	nucleotide binding site [chemical binding]; other site
543734003413	Mg binding site [ion binding]; other site
543734003414	putative protofilament interaction site [polypeptide binding]; other site
543734003415	RodZ interaction site [polypeptide binding]; other site
543734003416	Haemolytic domain; Region: Haemolytic; cl00506
543734003417	Protein of unknown function (DUF2969); Region: DUF2969; pfam11184
543734003418	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
543734003419	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
543734003420	lipoyl attachment site [posttranslational modification]; other site
543734003421	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
543734003422	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
543734003423	metal binding site [ion binding]; metal-binding site
543734003424	dimer interface [polypeptide binding]; other site
543734003425	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
543734003426	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
543734003427	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
543734003428	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
543734003429	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
543734003430	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
543734003431	Walker A/P-loop; other site
543734003432	ATP binding site [chemical binding]; other site
543734003433	Q-loop/lid; other site
543734003434	ABC transporter signature motif; other site
543734003435	Walker B; other site
543734003436	D-loop; other site
543734003437	H-loop/switch region; other site
543734003438	NIL domain; Region: NIL; pfam09383
543734003439	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734003440	dimer interface [polypeptide binding]; other site
543734003441	conserved gate region; other site
543734003442	ABC-ATPase subunit interface; other site
543734003443	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
543734003444	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
543734003445	Walker A/P-loop; other site
543734003446	ATP binding site [chemical binding]; other site
543734003447	Q-loop/lid; other site
543734003448	ABC transporter signature motif; other site
543734003449	Walker B; other site
543734003450	D-loop; other site
543734003451	H-loop/switch region; other site
543734003452	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
543734003453	FeS assembly protein SufD; Region: sufD; TIGR01981
543734003454	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
543734003455	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
543734003456	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
543734003457	catalytic residue [active]
543734003458	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
543734003459	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
543734003460	trimerization site [polypeptide binding]; other site
543734003461	active site
543734003462	FeS assembly protein SufB; Region: sufB; TIGR01980
543734003463	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
543734003464	Protein of unknown function (DUF1694); Region: DUF1694; pfam07997
543734003465	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
543734003466	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
543734003467	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734003468	active site
543734003469	motif I; other site
543734003470	motif II; other site
543734003471	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
543734003472	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734003473	non-specific DNA binding site [nucleotide binding]; other site
543734003474	salt bridge; other site
543734003475	sequence-specific DNA binding site [nucleotide binding]; other site
543734003476	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
543734003477	Ligand Binding Site [chemical binding]; other site
543734003478	recombination factor protein RarA; Reviewed; Region: PRK13342
543734003479	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
543734003480	Walker A motif; other site
543734003481	ATP binding site [chemical binding]; other site
543734003482	Walker B motif; other site
543734003483	arginine finger; other site
543734003484	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
543734003485	D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181
543734003486	Protein of unknown function (DUF1694); Region: DUF1694; pfam07997
543734003487	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
543734003488	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
543734003489	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
543734003490	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
543734003491	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
543734003492	putative L-serine binding site [chemical binding]; other site
543734003493	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
543734003494	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
543734003495	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
543734003496	catalytic core [active]
543734003497	methionine sulfoxide reductase A; Provisional; Region: PRK14054
543734003498	short chain dehydrogenase; Provisional; Region: PRK06197
543734003499	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
543734003500	putative NAD(P) binding site [chemical binding]; other site
543734003501	active site
543734003502	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
543734003503	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
543734003504	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
543734003505	active site
543734003506	hypothetical protein; Provisional; Region: PRK07329
543734003507	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
543734003508	active site
543734003509	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
543734003510	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
543734003511	peptide binding site [polypeptide binding]; other site
543734003512	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
543734003513	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
543734003514	dimer interface [polypeptide binding]; other site
543734003515	phosphorylation site [posttranslational modification]
543734003516	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
543734003517	ATP binding site [chemical binding]; other site
543734003518	Mg2+ binding site [ion binding]; other site
543734003519	G-X-G motif; other site
543734003520	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
543734003521	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
543734003522	active site
543734003523	phosphorylation site [posttranslational modification]
543734003524	intermolecular recognition site; other site
543734003525	dimerization interface [polypeptide binding]; other site
543734003526	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
543734003527	DNA binding site [nucleotide binding]
543734003528	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
543734003529	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734003530	Walker A/P-loop; other site
543734003531	ATP binding site [chemical binding]; other site
543734003532	Q-loop/lid; other site
543734003533	ABC transporter signature motif; other site
543734003534	Walker B; other site
543734003535	D-loop; other site
543734003536	H-loop/switch region; other site
543734003537	Transcriptional regulator [Transcription]; Region: LysR; COG0583
543734003538	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
543734003539	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
543734003540	dimerization interface [polypeptide binding]; other site
543734003541	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
543734003542	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
543734003543	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
543734003544	NADH(P)-binding; Region: NAD_binding_10; pfam13460
543734003545	NAD(P) binding site [chemical binding]; other site
543734003546	active site
543734003547	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
543734003548	dimerization interface [polypeptide binding]; other site
543734003549	putative DNA binding site [nucleotide binding]; other site
543734003550	putative Zn2+ binding site [ion binding]; other site
543734003551	glutathionine S-transferase; Provisional; Region: PRK10542
543734003552	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
543734003553	C-terminal domain interface [polypeptide binding]; other site
543734003554	GSH binding site (G-site) [chemical binding]; other site
543734003555	dimer interface [polypeptide binding]; other site
543734003556	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
543734003557	dimer interface [polypeptide binding]; other site
543734003558	substrate binding pocket (H-site) [chemical binding]; other site
543734003559	N-terminal domain interface [polypeptide binding]; other site
543734003560	SAP domain; Region: SAP; pfam02037
543734003561	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
543734003562	Coenzyme A binding pocket [chemical binding]; other site
543734003563	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
543734003564	Coenzyme A binding pocket [chemical binding]; other site
543734003565	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
543734003566	Coenzyme A binding pocket [chemical binding]; other site
543734003567	hypothetical protein
543734003568	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
543734003569	EDD domain protein, DegV family; Region: DegV; TIGR00762
543734003570	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
543734003571	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
543734003572	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
543734003573	active site
543734003574	phosphorylation site [posttranslational modification]
543734003575	intermolecular recognition site; other site
543734003576	dimerization interface [polypeptide binding]; other site
543734003577	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
543734003578	DNA binding residues [nucleotide binding]
543734003579	dimerization interface [polypeptide binding]; other site
543734003580	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
543734003581	Histidine kinase; Region: HisKA_3; pfam07730
543734003582	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
543734003583	ATP binding site [chemical binding]; other site
543734003584	Mg2+ binding site [ion binding]; other site
543734003585	G-X-G motif; other site
543734003586	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
543734003587	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
543734003588	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
543734003589	Walker A/P-loop; other site
543734003590	ATP binding site [chemical binding]; other site
543734003591	Q-loop/lid; other site
543734003592	ABC transporter signature motif; other site
543734003593	Walker B; other site
543734003594	D-loop; other site
543734003595	H-loop/switch region; other site
543734003596	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
543734003597	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
543734003598	DNA binding residues [nucleotide binding]
543734003599	dimer interface [polypeptide binding]; other site
543734003600	Protein of unknown function (DUF2568); Region: DUF2568; pfam10823
543734003601	Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664
543734003602	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
543734003603	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
543734003604	Coenzyme A binding pocket [chemical binding]; other site
543734003605	RelB antitoxin; Region: RelB; cl01171
543734003606	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
543734003607	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
543734003608	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
543734003609	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
543734003610	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
543734003611	RNA binding site [nucleotide binding]; other site
543734003612	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
543734003613	Helix-turn-helix domain; Region: HTH_38; pfam13936
543734003614	Integrase core domain; Region: rve; pfam00665
543734003615	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
543734003616	Transposase domain (DUF772); Region: DUF772; pfam05598
543734003617	AAA-like domain; Region: AAA_10; pfam12846
543734003618	Domain of unknown function DUF87; Region: DUF87; pfam01935
543734003619	SIR2-like domain; Region: SIR2_2; pfam13289
543734003620	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
543734003621	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
543734003622	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
543734003623	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
543734003624	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
543734003625	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
543734003626	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
543734003627	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
543734003628	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
543734003629	RNA binding surface [nucleotide binding]; other site
543734003630	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
543734003631	GAF domain; Region: GAF_2; pfam13185
543734003632	septation ring formation regulator EzrA; Provisional; Region: PRK04778
543734003633	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
543734003634	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
543734003635	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
543734003636	catalytic residue [active]
543734003637	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
543734003638	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
543734003639	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
543734003640	Ligand Binding Site [chemical binding]; other site
543734003641	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
543734003642	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
543734003643	CoA binding domain; Region: CoA_binding; pfam02629
543734003644	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
543734003645	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
543734003646	active site
543734003647	HIGH motif; other site
543734003648	nucleotide binding site [chemical binding]; other site
543734003649	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
543734003650	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
543734003651	active site
543734003652	KMSKS motif; other site
543734003653	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
543734003654	tRNA binding surface [nucleotide binding]; other site
543734003655	anticodon binding site; other site
543734003656	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
543734003657	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
543734003658	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
543734003659	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
543734003660	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734003661	motif II; other site
543734003662	hypothetical protein; Reviewed; Region: PRK00024
543734003663	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
543734003664	MPN+ (JAMM) motif; other site
543734003665	Zinc-binding site [ion binding]; other site
543734003666	rod shape-determining protein MreB; Provisional; Region: PRK13927
543734003667	MreB and similar proteins; Region: MreB_like; cd10225
543734003668	nucleotide binding site [chemical binding]; other site
543734003669	Mg binding site [ion binding]; other site
543734003670	putative protofilament interaction site [polypeptide binding]; other site
543734003671	RodZ interaction site [polypeptide binding]; other site
543734003672	rod shape-determining protein MreC; Provisional; Region: PRK13922
543734003673	rod shape-determining protein MreC; Region: MreC; pfam04085
543734003674	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
543734003675	septum formation inhibitor; Reviewed; Region: minC; PRK00513
543734003676	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
543734003677	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
543734003678	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
543734003679	Switch I; other site
543734003680	Switch II; other site
543734003681	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734003682	dimer interface [polypeptide binding]; other site
543734003683	conserved gate region; other site
543734003684	putative PBP binding loops; other site
543734003685	ABC-ATPase subunit interface; other site
543734003686	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
543734003687	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734003688	Walker A/P-loop; other site
543734003689	ATP binding site [chemical binding]; other site
543734003690	Q-loop/lid; other site
543734003691	ABC transporter signature motif; other site
543734003692	Walker B; other site
543734003693	D-loop; other site
543734003694	H-loop/switch region; other site
543734003695	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
543734003696	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
543734003697	substrate binding pocket [chemical binding]; other site
543734003698	membrane-bound complex binding site; other site
543734003699	hinge residues; other site
543734003700	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
543734003701	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
543734003702	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
543734003703	putative active site [active]
543734003704	catalytic site [active]
543734003705	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
543734003706	putative active site [active]
543734003707	catalytic site [active]
543734003708	cell division protein MraZ; Reviewed; Region: PRK00326
543734003709	MraZ protein; Region: MraZ; pfam02381
543734003710	MraZ protein; Region: MraZ; pfam02381
543734003711	MraW methylase family; Region: Methyltransf_5; pfam01795
543734003712	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
543734003713	Cell division protein FtsL; Region: FtsL; cl11433
543734003714	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
543734003715	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
543734003716	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
543734003717	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
543734003718	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
543734003719	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
543734003720	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
543734003721	Mg++ binding site [ion binding]; other site
543734003722	putative catalytic motif [active]
543734003723	putative substrate binding site [chemical binding]; other site
543734003724	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
543734003725	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
543734003726	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
543734003727	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
543734003728	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
543734003729	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
543734003730	active site
543734003731	homodimer interface [polypeptide binding]; other site
543734003732	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
543734003733	Cell division protein FtsQ; Region: FtsQ; pfam03799
543734003734	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
543734003735	Cell division protein FtsA; Region: FtsA; smart00842
543734003736	Cell division protein FtsA; Region: FtsA; pfam14450
543734003737	cell division protein FtsZ; Validated; Region: PRK09330
543734003738	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
543734003739	nucleotide binding site [chemical binding]; other site
543734003740	SulA interaction site; other site
543734003741	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
543734003742	YGGT family; Region: YGGT; pfam02325
543734003743	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
543734003744	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
543734003745	RNA binding surface [nucleotide binding]; other site
543734003746	DivIVA protein; Region: DivIVA; pfam05103
543734003747	DivIVA domain; Region: DivI1A_domain; TIGR03544
543734003748	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
543734003749	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
543734003750	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
543734003751	active site
543734003752	HIGH motif; other site
543734003753	nucleotide binding site [chemical binding]; other site
543734003754	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
543734003755	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
543734003756	active site
543734003757	KMSKS motif; other site
543734003758	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
543734003759	tRNA binding surface [nucleotide binding]; other site
543734003760	anticodon binding site; other site
543734003761	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
543734003762	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
543734003763	DNA-binding site [nucleotide binding]; DNA binding site
543734003764	RNA-binding motif; other site
543734003765	PBP superfamily domain; Region: PBP_like_2; cl17296
543734003766	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
543734003767	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
543734003768	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734003769	putative substrate translocation pore; other site
543734003770	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734003771	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
543734003772	5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112
543734003773	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
543734003774	dimer interface [polypeptide binding]; other site
543734003775	ADP-ribose binding site [chemical binding]; other site
543734003776	active site
543734003777	nudix motif; other site
543734003778	metal binding site [ion binding]; metal-binding site
543734003779	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
543734003780	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
543734003781	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
543734003782	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
543734003783	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
543734003784	catalytic residue [active]
543734003785	Putative amino acid metabolism; Region: DUF1831; pfam08866
543734003786	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734003787	Walker A/P-loop; other site
543734003788	ATP binding site [chemical binding]; other site
543734003789	Q-loop/lid; other site
543734003790	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734003791	ABC transporter signature motif; other site
543734003792	Walker B; other site
543734003793	D-loop; other site
543734003794	H-loop/switch region; other site
543734003795	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734003796	AAA domain; Region: AAA_21; pfam13304
543734003797	Walker A/P-loop; other site
543734003798	ATP binding site [chemical binding]; other site
543734003799	Q-loop/lid; other site
543734003800	ABC transporter signature motif; other site
543734003801	Walker B; other site
543734003802	D-loop; other site
543734003803	H-loop/switch region; other site
543734003804	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
543734003805	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
543734003806	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
543734003807	catalytic core [active]
543734003808	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
543734003809	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
543734003810	AAA domain; Region: AAA_30; pfam13604
543734003811	Family description; Region: UvrD_C_2; pfam13538
543734003812	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
543734003813	Sterol carrier protein domain; Region: SCP2_2; pfam13530
543734003814	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
543734003815	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
543734003816	Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440
543734003817	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
543734003818	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
543734003819	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
543734003820	Protein of unknown function (DUF1447); Region: DUF1447; pfam07288
543734003821	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
543734003822	active site
543734003823	catalytic residues [active]
543734003824	metal binding site [ion binding]; metal-binding site
543734003825	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
543734003826	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
543734003827	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
543734003828	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
543734003829	TPP-binding site [chemical binding]; other site
543734003830	tetramer interface [polypeptide binding]; other site
543734003831	heterodimer interface [polypeptide binding]; other site
543734003832	phosphorylation loop region [posttranslational modification]
543734003833	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
543734003834	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
543734003835	alpha subunit interface [polypeptide binding]; other site
543734003836	TPP binding site [chemical binding]; other site
543734003837	heterodimer interface [polypeptide binding]; other site
543734003838	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
543734003839	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
543734003840	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
543734003841	E3 interaction surface; other site
543734003842	lipoyl attachment site [posttranslational modification]; other site
543734003843	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
543734003844	E3 interaction surface; other site
543734003845	lipoyl attachment site [posttranslational modification]; other site
543734003846	e3 binding domain; Region: E3_binding; pfam02817
543734003847	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
543734003848	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
543734003849	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
543734003850	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
543734003851	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
543734003852	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
543734003853	NAD(P) binding site [chemical binding]; other site
543734003854	substrate binding site [chemical binding]; other site
543734003855	Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256
543734003856	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
543734003857	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
543734003858	active site
543734003859	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
543734003860	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
543734003861	G1 box; other site
543734003862	putative GEF interaction site [polypeptide binding]; other site
543734003863	GTP/Mg2+ binding site [chemical binding]; other site
543734003864	Switch I region; other site
543734003865	G2 box; other site
543734003866	G3 box; other site
543734003867	Switch II region; other site
543734003868	G4 box; other site
543734003869	G5 box; other site
543734003870	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
543734003871	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
543734003872	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
543734003873	pyruvate carboxylase; Reviewed; Region: PRK12999
543734003874	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
543734003875	ATP-grasp domain; Region: ATP-grasp_4; cl17255
543734003876	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
543734003877	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
543734003878	active site
543734003879	catalytic residues [active]
543734003880	metal binding site [ion binding]; metal-binding site
543734003881	homodimer binding site [polypeptide binding]; other site
543734003882	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
543734003883	carboxyltransferase (CT) interaction site; other site
543734003884	biotinylation site [posttranslational modification]; other site
543734003885	Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902
543734003886	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
543734003887	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
543734003888	S-adenosylmethionine binding site [chemical binding]; other site
543734003889	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
543734003890	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
543734003891	active site
543734003892	(T/H)XGH motif; other site
543734003893	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
543734003894	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
543734003895	protein binding site [polypeptide binding]; other site
543734003896	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
543734003897	SLBB domain; Region: SLBB; pfam10531
543734003898	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
543734003899	Helix-hairpin-helix motif; Region: HHH; pfam00633
543734003900	Competence protein; Region: Competence; pfam03772
543734003901	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
543734003902	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
543734003903	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
543734003904	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
543734003905	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
543734003906	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
543734003907	16S/18S rRNA binding site [nucleotide binding]; other site
543734003908	S13e-L30e interaction site [polypeptide binding]; other site
543734003909	25S rRNA binding site [nucleotide binding]; other site
543734003910	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
543734003911	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
543734003912	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
543734003913	elongation factor Tu; Reviewed; Region: PRK00049
543734003914	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
543734003915	G1 box; other site
543734003916	GEF interaction site [polypeptide binding]; other site
543734003917	GTP/Mg2+ binding site [chemical binding]; other site
543734003918	Switch I region; other site
543734003919	G2 box; other site
543734003920	G3 box; other site
543734003921	Switch II region; other site
543734003922	G4 box; other site
543734003923	G5 box; other site
543734003924	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
543734003925	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
543734003926	Antibiotic Binding Site [chemical binding]; other site
543734003927	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
543734003928	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
543734003929	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
543734003930	Walker A/P-loop; other site
543734003931	ATP binding site [chemical binding]; other site
543734003932	Q-loop/lid; other site
543734003933	ABC transporter signature motif; other site
543734003934	Walker B; other site
543734003935	D-loop; other site
543734003936	H-loop/switch region; other site
543734003937	trigger factor; Provisional; Region: tig; PRK01490
543734003938	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
543734003939	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
543734003940	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
543734003941	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
543734003942	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
543734003943	Walker A motif; other site
543734003944	ATP binding site [chemical binding]; other site
543734003945	Walker B motif; other site
543734003946	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
543734003947	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
543734003948	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
543734003949	G1 box; other site
543734003950	GTP/Mg2+ binding site [chemical binding]; other site
543734003951	Switch I region; other site
543734003952	G2 box; other site
543734003953	G3 box; other site
543734003954	Switch II region; other site
543734003955	G4 box; other site
543734003956	G5 box; other site
543734003957	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
543734003958	putative metal binding site [ion binding]; other site
543734003959	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
543734003960	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
543734003961	substrate binding pocket [chemical binding]; other site
543734003962	membrane-bound complex binding site; other site
543734003963	hinge residues; other site
543734003964	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
543734003965	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734003966	dimer interface [polypeptide binding]; other site
543734003967	conserved gate region; other site
543734003968	putative PBP binding loops; other site
543734003969	ABC-ATPase subunit interface; other site
543734003970	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
543734003971	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
543734003972	Walker A/P-loop; other site
543734003973	ATP binding site [chemical binding]; other site
543734003974	Q-loop/lid; other site
543734003975	ABC transporter signature motif; other site
543734003976	Walker B; other site
543734003977	D-loop; other site
543734003978	H-loop/switch region; other site
543734003979	Pleckstrin homology-like domain; Region: PH-like; cl17171
543734003980	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
543734003981	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
543734003982	GIY-YIG motif/motif A; other site
543734003983	active site
543734003984	catalytic site [active]
543734003985	putative DNA binding site [nucleotide binding]; other site
543734003986	metal binding site [ion binding]; metal-binding site
543734003987	UvrB/uvrC motif; Region: UVR; pfam02151
543734003988	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
543734003989	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
543734003990	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
543734003991	active site
543734003992	phosphorylation site [posttranslational modification]
543734003993	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
543734003994	active site
543734003995	P-loop; other site
543734003996	phosphorylation site [posttranslational modification]
543734003997	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
543734003998	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
543734003999	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
543734004000	putative substrate binding site [chemical binding]; other site
543734004001	putative ATP binding site [chemical binding]; other site
543734004002	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
543734004003	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
543734004004	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
543734004005	GTPase CgtA; Reviewed; Region: obgE; PRK12297
543734004006	GTP1/OBG; Region: GTP1_OBG; pfam01018
543734004007	Obg GTPase; Region: Obg; cd01898
543734004008	G1 box; other site
543734004009	GTP/Mg2+ binding site [chemical binding]; other site
543734004010	Switch I region; other site
543734004011	G2 box; other site
543734004012	G3 box; other site
543734004013	Switch II region; other site
543734004014	G4 box; other site
543734004015	G5 box; other site
543734004016	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
543734004017	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
543734004018	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
543734004019	catalytic triad [active]
543734004020	catalytic triad [active]
543734004021	oxyanion hole [active]
543734004022	ribonuclease Z; Region: RNase_Z; TIGR02651
543734004023	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
543734004024	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
543734004025	NAD(P) binding site [chemical binding]; other site
543734004026	active site
543734004027	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
543734004028	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
543734004029	Clp amino terminal domain; Region: Clp_N; pfam02861
543734004030	Clp amino terminal domain; Region: Clp_N; pfam02861
543734004031	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
543734004032	Walker A motif; other site
543734004033	ATP binding site [chemical binding]; other site
543734004034	Walker B motif; other site
543734004035	arginine finger; other site
543734004036	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
543734004037	Walker A motif; other site
543734004038	ATP binding site [chemical binding]; other site
543734004039	Walker B motif; other site
543734004040	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
543734004041	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
543734004042	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
543734004043	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
543734004044	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
543734004045	active site
543734004046	metal binding site [ion binding]; metal-binding site
543734004047	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
543734004048	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
543734004049	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
543734004050	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
543734004051	active site
543734004052	PHP Thumb interface [polypeptide binding]; other site
543734004053	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
543734004054	generic binding surface I; other site
543734004055	generic binding surface II; other site
543734004056	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
543734004057	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
543734004058	active site
543734004059	ADP/pyrophosphate binding site [chemical binding]; other site
543734004060	dimerization interface [polypeptide binding]; other site
543734004061	allosteric effector site; other site
543734004062	fructose-1,6-bisphosphate binding site; other site
543734004063	pyruvate kinase; Provisional; Region: PRK06354
543734004064	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
543734004065	domain interfaces; other site
543734004066	active site
543734004067	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
543734004068	Protein of unknown function (DUF441); Region: DUF441; pfam04284
543734004069	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
543734004070	S1 domain; Region: S1_2; pfam13509
543734004071	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
543734004072	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
543734004073	active site
543734004074	Int/Topo IB signature motif; other site
543734004075	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
543734004076	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
543734004077	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
543734004078	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
543734004079	RNA binding surface [nucleotide binding]; other site
543734004080	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
543734004081	active site
543734004082	Predicted membrane protein [Function unknown]; Region: COG3601
543734004083	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
543734004084	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
543734004085	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
543734004086	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
543734004087	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
543734004088	ATP binding site [chemical binding]; other site
543734004089	putative Mg++ binding site [ion binding]; other site
543734004090	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
543734004091	nucleotide binding region [chemical binding]; other site
543734004092	ATP-binding site [chemical binding]; other site
543734004093	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
543734004094	cytidylate kinase; Provisional; Region: cmk; PRK00023
543734004095	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
543734004096	CMP-binding site; other site
543734004097	The sites determining sugar specificity; other site
543734004098	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
543734004099	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
543734004100	RNA binding site [nucleotide binding]; other site
543734004101	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
543734004102	RNA binding site [nucleotide binding]; other site
543734004103	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
543734004104	RNA binding site [nucleotide binding]; other site
543734004105	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
543734004106	RNA binding site [nucleotide binding]; other site
543734004107	GTP-binding protein Der; Reviewed; Region: PRK00093
543734004108	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
543734004109	G1 box; other site
543734004110	GTP/Mg2+ binding site [chemical binding]; other site
543734004111	Switch I region; other site
543734004112	G2 box; other site
543734004113	Switch II region; other site
543734004114	G3 box; other site
543734004115	G4 box; other site
543734004116	G5 box; other site
543734004117	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
543734004118	G1 box; other site
543734004119	GTP/Mg2+ binding site [chemical binding]; other site
543734004120	Switch I region; other site
543734004121	G2 box; other site
543734004122	G3 box; other site
543734004123	Switch II region; other site
543734004124	G4 box; other site
543734004125	G5 box; other site
543734004126	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
543734004127	IHF dimer interface [polypeptide binding]; other site
543734004128	IHF - DNA interface [nucleotide binding]; other site
543734004129	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
543734004130	TPR motif; other site
543734004131	binding surface
543734004132	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
543734004133	binding surface
543734004134	TPR motif; other site
543734004135	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
543734004136	binding surface
543734004137	TPR motif; other site
543734004138	TPR repeat; Region: TPR_11; pfam13414
543734004139	Uncharacterized conserved protein [Function unknown]; Region: COG1284
543734004140	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
543734004141	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
543734004142	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
543734004143	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
543734004144	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
543734004145	active site
543734004146	NTP binding site [chemical binding]; other site
543734004147	metal binding triad [ion binding]; metal-binding site
543734004148	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
543734004149	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
543734004150	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
543734004151	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734004152	Walker A/P-loop; other site
543734004153	ATP binding site [chemical binding]; other site
543734004154	Q-loop/lid; other site
543734004155	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
543734004156	ABC transporter signature motif; other site
543734004157	Walker B; other site
543734004158	D-loop; other site
543734004159	ABC transporter; Region: ABC_tran_2; pfam12848
543734004160	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
543734004161	thymidylate synthase; Region: thym_sym; TIGR03284
543734004162	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
543734004163	dimerization interface [polypeptide binding]; other site
543734004164	active site
543734004165	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
543734004166	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
543734004167	folate binding site [chemical binding]; other site
543734004168	NADP+ binding site [chemical binding]; other site
543734004169	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
543734004170	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
543734004171	EDD domain protein, DegV family; Region: DegV; TIGR00762
543734004172	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
543734004173	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
543734004174	active site
543734004175	catalytic triad [active]
543734004176	oxyanion hole [active]
543734004177	Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911
543734004178	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
543734004179	hypothetical protein; Provisional; Region: PRK13672
543734004180	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
543734004181	C-terminal peptidase (prc); Region: prc; TIGR00225
543734004182	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
543734004183	protein binding site [polypeptide binding]; other site
543734004184	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
543734004185	Catalytic dyad [active]
543734004186	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
543734004187	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
543734004188	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
543734004189	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
543734004190	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734004191	sequence-specific DNA binding site [nucleotide binding]; other site
543734004192	salt bridge; other site
543734004193	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
543734004194	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
543734004195	GTP/Mg2+ binding site [chemical binding]; other site
543734004196	G4 box; other site
543734004197	G5 box; other site
543734004198	G1 box; other site
543734004199	Switch I region; other site
543734004200	G2 box; other site
543734004201	G3 box; other site
543734004202	Switch II region; other site
543734004203	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
543734004204	RNA/DNA hybrid binding site [nucleotide binding]; other site
543734004205	active site
543734004206	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
543734004207	DNA protecting protein DprA; Region: dprA; TIGR00732
543734004208	DNA topoisomerase I; Validated; Region: PRK05582
543734004209	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
543734004210	active site
543734004211	interdomain interaction site; other site
543734004212	putative metal-binding site [ion binding]; other site
543734004213	nucleotide binding site [chemical binding]; other site
543734004214	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
543734004215	domain I; other site
543734004216	DNA binding groove [nucleotide binding]
543734004217	phosphate binding site [ion binding]; other site
543734004218	domain II; other site
543734004219	domain III; other site
543734004220	nucleotide binding site [chemical binding]; other site
543734004221	catalytic site [active]
543734004222	domain IV; other site
543734004223	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
543734004224	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
543734004225	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
543734004226	Glucose inhibited division protein A; Region: GIDA; pfam01134
543734004227	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
543734004228	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
543734004229	active site
543734004230	Int/Topo IB signature motif; other site
543734004231	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
543734004232	active site
543734004233	HslU subunit interaction site [polypeptide binding]; other site
543734004234	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
543734004235	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
543734004236	Walker A motif; other site
543734004237	ATP binding site [chemical binding]; other site
543734004238	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
543734004239	Walker B motif; other site
543734004240	arginine finger; other site
543734004241	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
543734004242	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
543734004243	active site
543734004244	catalytic residues [active]
543734004245	membrane protein; Provisional; Region: PRK14392
543734004246	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
543734004247	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
543734004248	Mg2+ binding site [ion binding]; other site
543734004249	G-X-G motif; other site
543734004250	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
543734004251	anchoring element; other site
543734004252	dimer interface [polypeptide binding]; other site
543734004253	ATP binding site [chemical binding]; other site
543734004254	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
543734004255	active site
543734004256	putative metal-binding site [ion binding]; other site
543734004257	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
543734004258	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
543734004259	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
543734004260	CAP-like domain; other site
543734004261	active site
543734004262	primary dimer interface [polypeptide binding]; other site
543734004263	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
543734004264	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
543734004265	Pyruvate formate lyase 1; Region: PFL1; cd01678
543734004266	coenzyme A binding site [chemical binding]; other site
543734004267	active site
543734004268	catalytic residues [active]
543734004269	glycine loop; other site
543734004270	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
543734004271	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
543734004272	FeS/SAM binding site; other site
543734004273	Transcriptional regulator [Transcription]; Region: LysR; COG0583
543734004274	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
543734004275	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
543734004276	dimerization interface [polypeptide binding]; other site
543734004277	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
543734004278	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
543734004279	DHHA2 domain; Region: DHHA2; pfam02833
543734004280	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
543734004281	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
543734004282	active site
543734004283	DNA binding site [nucleotide binding]
543734004284	Int/Topo IB signature motif; other site
543734004285	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
543734004286	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
543734004287	Walker A/P-loop; other site
543734004288	ATP binding site [chemical binding]; other site
543734004289	Q-loop/lid; other site
543734004290	ABC transporter signature motif; other site
543734004291	Walker B; other site
543734004292	D-loop; other site
543734004293	H-loop/switch region; other site
543734004294	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
543734004295	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
543734004296	ATP binding site [chemical binding]; other site
543734004297	Mg2+ binding site [ion binding]; other site
543734004298	G-X-G motif; other site
543734004299	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
543734004300	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
543734004301	active site
543734004302	phosphorylation site [posttranslational modification]
543734004303	intermolecular recognition site; other site
543734004304	dimerization interface [polypeptide binding]; other site
543734004305	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
543734004306	DNA binding site [nucleotide binding]
543734004307	H+ Antiporter protein; Region: 2A0121; TIGR00900
543734004308	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734004309	putative substrate translocation pore; other site
543734004310	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
543734004311	Coenzyme A binding pocket [chemical binding]; other site
543734004312	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
543734004313	dimer interface [polypeptide binding]; other site
543734004314	FMN binding site [chemical binding]; other site
543734004315	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
543734004316	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
543734004317	pyridoxal 5'-phosphate binding site [chemical binding]; other site
543734004318	homodimer interface [polypeptide binding]; other site
543734004319	catalytic residue [active]
543734004320	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
543734004321	metal binding site [ion binding]; metal-binding site
543734004322	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
543734004323	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
543734004324	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
543734004325	substrate binding site [chemical binding]; other site
543734004326	glutamase interaction surface [polypeptide binding]; other site
543734004327	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
543734004328	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
543734004329	catalytic residues [active]
543734004330	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
543734004331	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
543734004332	putative active site [active]
543734004333	oxyanion strand; other site
543734004334	catalytic triad [active]
543734004335	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
543734004336	4-fold oligomerization interface [polypeptide binding]; other site
543734004337	putative active site pocket [active]
543734004338	metal binding residues [ion binding]; metal-binding site
543734004339	3-fold/trimer interface [polypeptide binding]; other site
543734004340	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
543734004341	histidinol dehydrogenase; Region: hisD; TIGR00069
543734004342	NAD binding site [chemical binding]; other site
543734004343	dimerization interface [polypeptide binding]; other site
543734004344	product binding site; other site
543734004345	substrate binding site [chemical binding]; other site
543734004346	zinc binding site [ion binding]; other site
543734004347	catalytic residues [active]
543734004348	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
543734004349	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
543734004350	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
543734004351	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
543734004352	dimer interface [polypeptide binding]; other site
543734004353	motif 1; other site
543734004354	active site
543734004355	motif 2; other site
543734004356	motif 3; other site
543734004357	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
543734004358	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
543734004359	pyridoxal 5'-phosphate binding site [chemical binding]; other site
543734004360	homodimer interface [polypeptide binding]; other site
543734004361	catalytic residue [active]
543734004362	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
543734004363	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
543734004364	dimer interface [polypeptide binding]; other site
543734004365	ADP-ribose binding site [chemical binding]; other site
543734004366	active site
543734004367	nudix motif; other site
543734004368	metal binding site [ion binding]; metal-binding site
543734004369	EDD domain protein, DegV family; Region: DegV; TIGR00762
543734004370	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
543734004371	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
543734004372	Domain of unknown function (DUF814); Region: DUF814; pfam05670
543734004373	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Sulfolobus solfataricus (Ss) and its homologs from archaea and bacteria; Region: NTP-PPase_SsMazG; cd11535
543734004374	metal binding site [ion binding]; metal-binding site
543734004375	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
543734004376	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
543734004377	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
543734004378	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
543734004379	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
543734004380	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
543734004381	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
543734004382	E3 interaction surface; other site
543734004383	lipoyl attachment site [posttranslational modification]; other site
543734004384	e3 binding domain; Region: E3_binding; pfam02817
543734004385	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
543734004386	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
543734004387	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
543734004388	alpha subunit interface [polypeptide binding]; other site
543734004389	TPP binding site [chemical binding]; other site
543734004390	heterodimer interface [polypeptide binding]; other site
543734004391	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
543734004392	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
543734004393	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
543734004394	tetramer interface [polypeptide binding]; other site
543734004395	TPP-binding site [chemical binding]; other site
543734004396	heterodimer interface [polypeptide binding]; other site
543734004397	phosphorylation loop region [posttranslational modification]
543734004398	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
543734004399	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
543734004400	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
543734004401	butyrate kinase; Provisional; Region: PRK03011
543734004402	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
543734004403	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
543734004404	active site
543734004405	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
543734004406	active site
543734004407	dimer interface [polypeptide binding]; other site
543734004408	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
543734004409	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
543734004410	heterodimer interface [polypeptide binding]; other site
543734004411	active site
543734004412	FMN binding site [chemical binding]; other site
543734004413	homodimer interface [polypeptide binding]; other site
543734004414	substrate binding site [chemical binding]; other site
543734004415	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
543734004416	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
543734004417	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
543734004418	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
543734004419	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
543734004420	ATP-grasp domain; Region: ATP-grasp_4; cl17255
543734004421	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
543734004422	IMP binding site; other site
543734004423	dimer interface [polypeptide binding]; other site
543734004424	interdomain contacts; other site
543734004425	partial ornithine binding site; other site
543734004426	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
543734004427	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
543734004428	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
543734004429	catalytic site [active]
543734004430	subunit interface [polypeptide binding]; other site
543734004431	dihydroorotase; Validated; Region: pyrC; PRK09357
543734004432	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
543734004433	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
543734004434	active site
543734004435	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
543734004436	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
543734004437	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
543734004438	uracil transporter; Provisional; Region: PRK10720
543734004439	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
543734004440	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
543734004441	active site
543734004442	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
543734004443	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
543734004444	RNA binding surface [nucleotide binding]; other site
543734004445	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
543734004446	active site
543734004447	lipoprotein signal peptidase; Provisional; Region: PRK14797
543734004448	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
543734004449	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
543734004450	Potassium binding sites [ion binding]; other site
543734004451	Cesium cation binding sites [ion binding]; other site
543734004452	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
543734004453	RNA/DNA hybrid binding site [nucleotide binding]; other site
543734004454	active site
543734004455	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
543734004456	dimer interface [polypeptide binding]; other site
543734004457	FMN binding site [chemical binding]; other site
543734004458	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
543734004459	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
543734004460	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
543734004461	putative active site [active]
543734004462	catalytic site [active]
543734004463	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
543734004464	putative active site [active]
543734004465	catalytic site [active]
543734004466	Mga helix-turn-helix domain; Region: Mga; pfam05043
543734004467	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
543734004468	catalytic residues [active]
543734004469	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
543734004470	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
543734004471	Class I ribonucleotide reductase; Region: RNR_I; cd01679
543734004472	active site
543734004473	dimer interface [polypeptide binding]; other site
543734004474	catalytic residues [active]
543734004475	effector binding site; other site
543734004476	R2 peptide binding site; other site
543734004477	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
543734004478	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
543734004479	dimer interface [polypeptide binding]; other site
543734004480	putative radical transfer pathway; other site
543734004481	diiron center [ion binding]; other site
543734004482	tyrosyl radical; other site
543734004483	Transcriptional regulator [Transcription]; Region: LysR; COG0583
543734004484	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
543734004485	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
543734004486	dimerization interface [polypeptide binding]; other site
543734004487	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
543734004488	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
543734004489	active site
543734004490	Zn binding site [ion binding]; other site
543734004491	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
543734004492	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
543734004493	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
543734004494	Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155
543734004495	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
543734004496	putative ligand binding site [chemical binding]; other site
543734004497	NAD binding site [chemical binding]; other site
543734004498	catalytic site [active]
543734004499	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
543734004500	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
543734004501	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
543734004502	cell division protein GpsB; Provisional; Region: PRK14127
543734004503	DivIVA domain; Region: DivI1A_domain; TIGR03544
543734004504	hypothetical protein; Provisional; Region: PRK13660
543734004505	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
543734004506	Transglycosylase; Region: Transgly; pfam00912
543734004507	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
543734004508	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
543734004509	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
543734004510	catalytic motif [active]
543734004511	Zn binding site [ion binding]; other site
543734004512	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
543734004513	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
543734004514	minor groove reading motif; other site
543734004515	helix-hairpin-helix signature motif; other site
543734004516	substrate binding pocket [chemical binding]; other site
543734004517	active site
543734004518	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
543734004519	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
543734004520	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
543734004521	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
543734004522	putative dimer interface [polypeptide binding]; other site
543734004523	putative anticodon binding site; other site
543734004524	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
543734004525	homodimer interface [polypeptide binding]; other site
543734004526	motif 1; other site
543734004527	motif 2; other site
543734004528	active site
543734004529	motif 3; other site
543734004530	aspartate aminotransferase; Provisional; Region: PRK05764
543734004531	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
543734004532	pyridoxal 5'-phosphate binding site [chemical binding]; other site
543734004533	homodimer interface [polypeptide binding]; other site
543734004534	catalytic residue [active]
543734004535	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
543734004536	DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407
543734004537	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
543734004538	active site
543734004539	catalytic site [active]
543734004540	substrate binding site [chemical binding]; other site
543734004541	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
543734004542	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
543734004543	DEAD/DEAH box helicase; Region: DEAD; pfam00270
543734004544	ATP binding site [chemical binding]; other site
543734004545	Family description; Region: UvrD_C_2; pfam13538
543734004546	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
543734004547	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
543734004548	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
543734004549	mevalonate kinase; Region: mevalon_kin; TIGR00549
543734004550	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
543734004551	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
543734004552	diphosphomevalonate decarboxylase; Region: PLN02407
543734004553	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
543734004554	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
543734004555	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
543734004556	homotetramer interface [polypeptide binding]; other site
543734004557	FMN binding site [chemical binding]; other site
543734004558	homodimer contacts [polypeptide binding]; other site
543734004559	putative active site [active]
543734004560	putative substrate binding site [chemical binding]; other site
543734004561	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
543734004562	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
543734004563	S-adenosylmethionine binding site [chemical binding]; other site
543734004564	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
543734004565	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
543734004566	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
543734004567	4-oxalocrotonate tautomerase; Provisional; Region: PRK02220
543734004568	active site 1 [active]
543734004569	dimer interface [polypeptide binding]; other site
543734004570	hexamer interface [polypeptide binding]; other site
543734004571	active site 2 [active]
543734004572	Uncharacterized conserved protein [Function unknown]; Region: COG0327
543734004573	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
543734004574	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
543734004575	Family of unknown function (DUF633); Region: DUF633; pfam04816
543734004576	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
543734004577	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
543734004578	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
543734004579	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
543734004580	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
543734004581	DNA binding residues [nucleotide binding]
543734004582	DNA primase; Validated; Region: dnaG; PRK05667
543734004583	CHC2 zinc finger; Region: zf-CHC2; pfam01807
543734004584	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
543734004585	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
543734004586	active site
543734004587	metal binding site [ion binding]; metal-binding site
543734004588	interdomain interaction site; other site
543734004589	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
543734004590	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
543734004591	glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348
543734004592	dimer interface [polypeptide binding]; other site
543734004593	motif 2; other site
543734004594	active site
543734004595	motif 3; other site
543734004596	Recombination protein O N terminal; Region: RecO_N; pfam11967
543734004597	DNA repair protein RecO; Region: reco; TIGR00613
543734004598	Recombination protein O C terminal; Region: RecO_C; pfam02565
543734004599	GTPase Era; Reviewed; Region: era; PRK00089
543734004600	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
543734004601	G1 box; other site
543734004602	GTP/Mg2+ binding site [chemical binding]; other site
543734004603	Switch I region; other site
543734004604	G2 box; other site
543734004605	Switch II region; other site
543734004606	G3 box; other site
543734004607	G4 box; other site
543734004608	G5 box; other site
543734004609	KH domain; Region: KH_2; pfam07650
543734004610	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
543734004611	active site
543734004612	catalytic motif [active]
543734004613	Zn binding site [ion binding]; other site
543734004614	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
543734004615	metal-binding heat shock protein; Provisional; Region: PRK00016
543734004616	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
543734004617	PhoH-like protein; Region: PhoH; pfam02562
543734004618	Yqey-like protein; Region: YqeY; pfam09424
543734004619	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
543734004620	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
543734004621	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
543734004622	endonuclease IV; Provisional; Region: PRK01060
543734004623	AP (apurinic/apyrimidinic) site pocket; other site
543734004624	DNA interaction; other site
543734004625	Metal-binding active site; metal-binding site
543734004626	Uncharacterized conserved protein [Function unknown]; Region: COG1284
543734004627	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
543734004628	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
543734004629	methionine sulfoxide reductase B; Provisional; Region: PRK00222
543734004630	SelR domain; Region: SelR; pfam01641
543734004631	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
543734004632	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
543734004633	dimer interface [polypeptide binding]; other site
543734004634	anticodon binding site; other site
543734004635	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
543734004636	homodimer interface [polypeptide binding]; other site
543734004637	motif 1; other site
543734004638	active site
543734004639	motif 2; other site
543734004640	GAD domain; Region: GAD; pfam02938
543734004641	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
543734004642	motif 3; other site
543734004643	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
543734004644	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
543734004645	dimer interface [polypeptide binding]; other site
543734004646	motif 1; other site
543734004647	active site
543734004648	motif 2; other site
543734004649	motif 3; other site
543734004650	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
543734004651	anticodon binding site; other site
543734004652	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217
543734004653	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
543734004654	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
543734004655	putative NAD(P) binding site [chemical binding]; other site
543734004656	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
543734004657	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734004658	non-specific DNA binding site [nucleotide binding]; other site
543734004659	salt bridge; other site
543734004660	sequence-specific DNA binding site [nucleotide binding]; other site
543734004661	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
543734004662	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
543734004663	Walker A/P-loop; other site
543734004664	ATP binding site [chemical binding]; other site
543734004665	Q-loop/lid; other site
543734004666	ABC transporter signature motif; other site
543734004667	Walker B; other site
543734004668	D-loop; other site
543734004669	H-loop/switch region; other site
543734004670	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
543734004671	Bacterial SH3 domain; Region: SH3_3; pfam08239
543734004672	Bacterial SH3 domain; Region: SH3_3; pfam08239
543734004673	Bacterial SH3 domain homologues; Region: SH3b; smart00287
543734004674	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
543734004675	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
543734004676	active site
543734004677	metal binding site [ion binding]; metal-binding site
543734004678	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
543734004679	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734004680	motif II; other site
543734004681	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
543734004682	putative active site [active]
543734004683	dimerization interface [polypeptide binding]; other site
543734004684	putative tRNAtyr binding site [nucleotide binding]; other site
543734004685	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
543734004686	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
543734004687	Zn2+ binding site [ion binding]; other site
543734004688	Mg2+ binding site [ion binding]; other site
543734004689	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
543734004690	synthetase active site [active]
543734004691	NTP binding site [chemical binding]; other site
543734004692	metal binding site [ion binding]; metal-binding site
543734004693	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
543734004694	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
543734004695	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
543734004696	RNA methyltransferase, RsmE family; Region: TIGR00046
543734004697	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
543734004698	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
543734004699	S-adenosylmethionine binding site [chemical binding]; other site
543734004700	Protein of unknown function (DUF3013); Region: DUF3013; pfam11217
543734004701	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
543734004702	active site
543734004703	DNA binding site [nucleotide binding]
543734004704	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
543734004705	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
543734004706	Coenzyme A binding pocket [chemical binding]; other site
543734004707	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
543734004708	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
543734004709	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
543734004710	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
543734004711	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
543734004712	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
543734004713	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
543734004714	putative deacylase active site [active]
543734004715	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
543734004716	active site
543734004717	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
543734004718	DHH family; Region: DHH; pfam01368
543734004719	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538
543734004720	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
543734004721	GTP-binding protein LepA; Provisional; Region: PRK05433
543734004722	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
543734004723	G1 box; other site
543734004724	putative GEF interaction site [polypeptide binding]; other site
543734004725	GTP/Mg2+ binding site [chemical binding]; other site
543734004726	Switch I region; other site
543734004727	G2 box; other site
543734004728	G3 box; other site
543734004729	Switch II region; other site
543734004730	G4 box; other site
543734004731	G5 box; other site
543734004732	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
543734004733	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
543734004734	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
543734004735	chaperone protein DnaJ; Provisional; Region: PRK14276
543734004736	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
543734004737	HSP70 interaction site [polypeptide binding]; other site
543734004738	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
543734004739	substrate binding site [polypeptide binding]; other site
543734004740	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
543734004741	Zn binding sites [ion binding]; other site
543734004742	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
543734004743	dimer interface [polypeptide binding]; other site
543734004744	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
543734004745	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
543734004746	nucleotide binding site [chemical binding]; other site
543734004747	NEF interaction site [polypeptide binding]; other site
543734004748	SBD interface [polypeptide binding]; other site
543734004749	GrpE; Region: GrpE; pfam01025
543734004750	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
543734004751	dimer interface [polypeptide binding]; other site
543734004752	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
543734004753	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
543734004754	HTH domain; Region: HTH_11; pfam08279
543734004755	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
543734004756	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
543734004757	FeS/SAM binding site; other site
543734004758	HemN C-terminal domain; Region: HemN_C; pfam06969
543734004759	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
543734004760	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
543734004761	active site
543734004762	Riboflavin kinase; Region: Flavokinase; smart00904
543734004763	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484
543734004764	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
543734004765	RNA binding site [nucleotide binding]; other site
543734004766	active site
543734004767	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
543734004768	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
543734004769	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
543734004770	translation initiation factor IF-2; Region: IF-2; TIGR00487
543734004771	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
543734004772	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
543734004773	G1 box; other site
543734004774	putative GEF interaction site [polypeptide binding]; other site
543734004775	GTP/Mg2+ binding site [chemical binding]; other site
543734004776	Switch I region; other site
543734004777	G2 box; other site
543734004778	G3 box; other site
543734004779	Switch II region; other site
543734004780	G4 box; other site
543734004781	G5 box; other site
543734004782	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
543734004783	Translation-initiation factor 2; Region: IF-2; pfam11987
543734004784	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
543734004785	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
543734004786	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
543734004787	putative RNA binding cleft [nucleotide binding]; other site
543734004788	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
543734004789	NusA N-terminal domain; Region: NusA_N; pfam08529
543734004790	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
543734004791	RNA binding site [nucleotide binding]; other site
543734004792	homodimer interface [polypeptide binding]; other site
543734004793	NusA-like KH domain; Region: KH_5; pfam13184
543734004794	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
543734004795	G-X-X-G motif; other site
543734004796	ribosome maturation protein RimP; Reviewed; Region: PRK00092
543734004797	Sm and related proteins; Region: Sm_like; cl00259
543734004798	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
543734004799	putative oligomer interface [polypeptide binding]; other site
543734004800	putative RNA binding site [nucleotide binding]; other site
543734004801	DNA polymerase III PolC; Validated; Region: polC; PRK00448
543734004802	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
543734004803	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
543734004804	generic binding surface II; other site
543734004805	generic binding surface I; other site
543734004806	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
543734004807	active site
543734004808	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
543734004809	active site
543734004810	catalytic site [active]
543734004811	substrate binding site [chemical binding]; other site
543734004812	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
543734004813	prolyl-tRNA synthetase; Provisional; Region: PRK09194
543734004814	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
543734004815	dimer interface [polypeptide binding]; other site
543734004816	motif 1; other site
543734004817	active site
543734004818	motif 2; other site
543734004819	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
543734004820	putative deacylase active site [active]
543734004821	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
543734004822	active site
543734004823	motif 3; other site
543734004824	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
543734004825	anticodon binding site; other site
543734004826	RIP metalloprotease RseP; Region: TIGR00054
543734004827	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
543734004828	active site
543734004829	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
543734004830	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
543734004831	protein binding site [polypeptide binding]; other site
543734004832	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
543734004833	putative substrate binding region [chemical binding]; other site
543734004834	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
543734004835	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
543734004836	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
543734004837	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830
543734004838	catalytic residue [active]
543734004839	putative FPP diphosphate  binding site; other site
543734004840	putative FPP binding hydrophobic cleft; other site
543734004841	dimer interface [polypeptide binding]; other site
543734004842	putative IPP diphosphate binding site; other site
543734004843	ribosome recycling factor; Reviewed; Region: frr; PRK00083
543734004844	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
543734004845	hinge region; other site
543734004846	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
543734004847	putative nucleotide binding site [chemical binding]; other site
543734004848	uridine monophosphate binding site [chemical binding]; other site
543734004849	homohexameric interface [polypeptide binding]; other site
543734004850	elongation factor Ts; Provisional; Region: tsf; PRK09377
543734004851	UBA/TS-N domain; Region: UBA; pfam00627
543734004852	Elongation factor TS; Region: EF_TS; pfam00889
543734004853	Elongation factor TS; Region: EF_TS; pfam00889
543734004854	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
543734004855	rRNA interaction site [nucleotide binding]; other site
543734004856	S8 interaction site; other site
543734004857	putative laminin-1 binding site; other site
543734004858	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
543734004859	GIY-YIG motif/motif A; other site
543734004860	putative active site [active]
543734004861	putative metal binding site [ion binding]; other site
543734004862	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
543734004863	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
543734004864	S-adenosylmethionine binding site [chemical binding]; other site
543734004865	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
543734004866	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
543734004867	putative acyl-acceptor binding pocket; other site
543734004868	amino acid transporter; Region: 2A0306; TIGR00909
543734004869	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
543734004870	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
543734004871	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
543734004872	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
543734004873	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
543734004874	Walker A/P-loop; other site
543734004875	ATP binding site [chemical binding]; other site
543734004876	Q-loop/lid; other site
543734004877	ABC transporter signature motif; other site
543734004878	Walker B; other site
543734004879	D-loop; other site
543734004880	H-loop/switch region; other site
543734004881	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
543734004882	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
543734004883	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734004884	Walker A/P-loop; other site
543734004885	ATP binding site [chemical binding]; other site
543734004886	Q-loop/lid; other site
543734004887	ABC transporter signature motif; other site
543734004888	Walker B; other site
543734004889	D-loop; other site
543734004890	H-loop/switch region; other site
543734004891	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
543734004892	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
543734004893	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
543734004894	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
543734004895	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
543734004896	RimM N-terminal domain; Region: RimM; pfam01782
543734004897	PRC-barrel domain; Region: PRC; pfam05239
543734004898	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
543734004899	KH domain; Region: KH_4; pfam13083
543734004900	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
543734004901	signal recognition particle protein; Provisional; Region: PRK10867
543734004902	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
543734004903	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
543734004904	P loop; other site
543734004905	GTP binding site [chemical binding]; other site
543734004906	Signal peptide binding domain; Region: SRP_SPB; pfam02978
543734004907	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
543734004908	putative DNA-binding protein; Validated; Region: PRK00118
543734004909	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
543734004910	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
543734004911	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
543734004912	P loop; other site
543734004913	GTP binding site [chemical binding]; other site
543734004914	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
543734004915	AAA domain; Region: AAA_23; pfam13476
543734004916	Walker A/P-loop; other site
543734004917	ATP binding site [chemical binding]; other site
543734004918	Q-loop/lid; other site
543734004919	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
543734004920	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
543734004921	ABC transporter signature motif; other site
543734004922	Walker B; other site
543734004923	D-loop; other site
543734004924	H-loop/switch region; other site
543734004925	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
543734004926	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
543734004927	dimerization interface [polypeptide binding]; other site
543734004928	active site
543734004929	metal binding site [ion binding]; metal-binding site
543734004930	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
543734004931	The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510
543734004932	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
543734004933	peptide binding site [polypeptide binding]; other site
543734004934	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
543734004935	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
543734004936	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734004937	dimer interface [polypeptide binding]; other site
543734004938	conserved gate region; other site
543734004939	putative PBP binding loops; other site
543734004940	ABC-ATPase subunit interface; other site
543734004941	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
543734004942	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734004943	ABC-ATPase subunit interface; other site
543734004944	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
543734004945	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
543734004946	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
543734004947	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
543734004948	Walker A/P-loop; other site
543734004949	ATP binding site [chemical binding]; other site
543734004950	Q-loop/lid; other site
543734004951	ABC transporter signature motif; other site
543734004952	Walker B; other site
543734004953	D-loop; other site
543734004954	H-loop/switch region; other site
543734004955	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
543734004956	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
543734004957	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
543734004958	Walker A/P-loop; other site
543734004959	ATP binding site [chemical binding]; other site
543734004960	Q-loop/lid; other site
543734004961	ABC transporter signature motif; other site
543734004962	Walker B; other site
543734004963	D-loop; other site
543734004964	H-loop/switch region; other site
543734004965	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
543734004966	acyl carrier protein; Provisional; Region: acpP; PRK00982
543734004967	putative phosphate acyltransferase; Provisional; Region: PRK05331
543734004968	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
543734004969	Y-family of DNA polymerases; Region: PolY; cl12025
543734004970	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
543734004971	generic binding surface II; other site
543734004972	ssDNA binding site; other site
543734004973	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
543734004974	ATP binding site [chemical binding]; other site
543734004975	putative Mg++ binding site [ion binding]; other site
543734004976	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
543734004977	nucleotide binding region [chemical binding]; other site
543734004978	ATP-binding site [chemical binding]; other site
543734004979	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
543734004980	DAK2 domain; Region: Dak2; pfam02734
543734004981	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
543734004982	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
543734004983	Thiamine pyrophosphokinase; Region: TPK; cd07995
543734004984	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
543734004985	active site
543734004986	dimerization interface [polypeptide binding]; other site
543734004987	thiamine binding site [chemical binding]; other site
543734004988	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
543734004989	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
543734004990	substrate binding site [chemical binding]; other site
543734004991	hexamer interface [polypeptide binding]; other site
543734004992	metal binding site [ion binding]; metal-binding site
543734004993	GTPase RsgA; Reviewed; Region: PRK00098
543734004994	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
543734004995	RNA binding site [nucleotide binding]; other site
543734004996	homodimer interface [polypeptide binding]; other site
543734004997	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
543734004998	GTPase/Zn-binding domain interface [polypeptide binding]; other site
543734004999	GTP/Mg2+ binding site [chemical binding]; other site
543734005000	G4 box; other site
543734005001	G5 box; other site
543734005002	G1 box; other site
543734005003	Switch I region; other site
543734005004	G2 box; other site
543734005005	G3 box; other site
543734005006	Switch II region; other site
543734005007	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
543734005008	Catalytic domain of Protein Kinases; Region: PKc; cd00180
543734005009	active site
543734005010	ATP binding site [chemical binding]; other site
543734005011	substrate binding site [chemical binding]; other site
543734005012	activation loop (A-loop); other site
543734005013	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
543734005014	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
543734005015	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
543734005016	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
543734005017	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
543734005018	active site
543734005019	16S rRNA methyltransferase B; Provisional; Region: PRK14902
543734005020	NusB family; Region: NusB; pfam01029
543734005021	putative RNA binding site [nucleotide binding]; other site
543734005022	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
543734005023	S-adenosylmethionine binding site [chemical binding]; other site
543734005024	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
543734005025	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
543734005026	putative active site [active]
543734005027	substrate binding site [chemical binding]; other site
543734005028	putative cosubstrate binding site; other site
543734005029	catalytic site [active]
543734005030	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
543734005031	substrate binding site [chemical binding]; other site
543734005032	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
543734005033	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
543734005034	ATP binding site [chemical binding]; other site
543734005035	putative Mg++ binding site [ion binding]; other site
543734005036	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
543734005037	nucleotide binding region [chemical binding]; other site
543734005038	ATP-binding site [chemical binding]; other site
543734005039	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
543734005040	Flavoprotein; Region: Flavoprotein; pfam02441
543734005041	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
543734005042	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
543734005043	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
543734005044	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
543734005045	catalytic site [active]
543734005046	G-X2-G-X-G-K; other site
543734005047	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
543734005048	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
543734005049	nucleophile elbow; other site
543734005050	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
543734005051	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
543734005052	Walker A/P-loop; other site
543734005053	ATP binding site [chemical binding]; other site
543734005054	Q-loop/lid; other site
543734005055	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
543734005056	ABC transporter signature motif; other site
543734005057	Walker B; other site
543734005058	D-loop; other site
543734005059	H-loop/switch region; other site
543734005060	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
543734005061	arginine repressor; Provisional; Region: PRK04280
543734005062	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
543734005063	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
543734005064	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
543734005065	RNA binding surface [nucleotide binding]; other site
543734005066	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
543734005067	S-adenosylmethionine binding site [chemical binding]; other site
543734005068	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
543734005069	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
543734005070	substrate binding pocket [chemical binding]; other site
543734005071	chain length determination region; other site
543734005072	substrate-Mg2+ binding site; other site
543734005073	catalytic residues [active]
543734005074	aspartate-rich region 1; other site
543734005075	active site lid residues [active]
543734005076	aspartate-rich region 2; other site
543734005077	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
543734005078	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
543734005079	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
543734005080	generic binding surface II; other site
543734005081	generic binding surface I; other site
543734005082	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14169
543734005083	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
543734005084	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
543734005085	homodimer interface [polypeptide binding]; other site
543734005086	NADP binding site [chemical binding]; other site
543734005087	substrate binding site [chemical binding]; other site
543734005088	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
543734005089	putative RNA binding site [nucleotide binding]; other site
543734005090	Asp23 family; Region: Asp23; pfam03780
543734005091	elongation factor P; Validated; Region: PRK00529
543734005092	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
543734005093	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
543734005094	RNA binding site [nucleotide binding]; other site
543734005095	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
543734005096	RNA binding site [nucleotide binding]; other site
543734005097	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
543734005098	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
543734005099	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
543734005100	active site
543734005101	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
543734005102	Protein of unknown function (DUF464); Region: DUF464; pfam04327
543734005103	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
543734005104	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
543734005105	X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168
543734005106	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
543734005107	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
543734005108	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
543734005109	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
543734005110	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
543734005111	DNA binding residues [nucleotide binding]
543734005112	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
543734005113	putative dimer interface [polypeptide binding]; other site
543734005114	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
543734005115	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
543734005116	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
543734005117	catalytic residue [active]
543734005118	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
543734005119	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
543734005120	Aluminium resistance protein; Region: Alum_res; pfam06838
543734005121	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
543734005122	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
543734005123	Protein of unknown function (DUF3042); Region: DUF3042; pfam11240
543734005124	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
543734005125	active site residue [active]
543734005126	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
543734005127	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
543734005128	nucleotide binding site [chemical binding]; other site
543734005129	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
543734005130	Rhomboid family; Region: Rhomboid; pfam01694
543734005131	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
543734005132	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
543734005133	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
543734005134	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
543734005135	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
543734005136	Helix-turn-helix domain; Region: HTH_38; pfam13936
543734005137	Integrase core domain; Region: rve; pfam00665
543734005138	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
543734005139	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
543734005140	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
543734005141	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
543734005142	active site
543734005143	phosphorylation site [posttranslational modification]
543734005144	intermolecular recognition site; other site
543734005145	dimerization interface [polypeptide binding]; other site
543734005146	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
543734005147	DNA binding residues [nucleotide binding]
543734005148	dimerization interface [polypeptide binding]; other site
543734005149	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
543734005150	Histidine kinase; Region: HisKA_3; pfam07730
543734005151	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
543734005152	ATP binding site [chemical binding]; other site
543734005153	Mg2+ binding site [ion binding]; other site
543734005154	G-X-G motif; other site
543734005155	Predicted membrane protein [Function unknown]; Region: COG4758
543734005156	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
543734005157	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
543734005158	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
543734005159	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
543734005160	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
543734005161	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
543734005162	ATP-binding site [chemical binding]; other site
543734005163	Sugar specificity; other site
543734005164	Pyrimidine base specificity; other site
543734005165	YceG-like family; Region: YceG; pfam02618
543734005166	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
543734005167	dimerization interface [polypeptide binding]; other site
543734005168	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
543734005169	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
543734005170	putative tRNA-binding site [nucleotide binding]; other site
543734005171	B3/4 domain; Region: B3_4; pfam03483
543734005172	tRNA synthetase B5 domain; Region: B5; smart00874
543734005173	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
543734005174	dimer interface [polypeptide binding]; other site
543734005175	motif 1; other site
543734005176	motif 3; other site
543734005177	motif 2; other site
543734005178	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
543734005179	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
543734005180	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
543734005181	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
543734005182	dimer interface [polypeptide binding]; other site
543734005183	motif 1; other site
543734005184	active site
543734005185	motif 2; other site
543734005186	motif 3; other site
543734005187	Predicted transcriptional regulators [Transcription]; Region: COG1733
543734005188	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
543734005189	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
543734005190	Zn2+ binding site [ion binding]; other site
543734005191	Mg2+ binding site [ion binding]; other site
543734005192	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
543734005193	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
543734005194	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
543734005195	Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254
543734005196	OxaA-like protein precursor; Provisional; Region: PRK02463
543734005197	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
543734005198	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
543734005199	HAMP domain; Region: HAMP; pfam00672
543734005200	dimerization interface [polypeptide binding]; other site
543734005201	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
543734005202	dimer interface [polypeptide binding]; other site
543734005203	phosphorylation site [posttranslational modification]
543734005204	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
543734005205	ATP binding site [chemical binding]; other site
543734005206	Mg2+ binding site [ion binding]; other site
543734005207	G-X-G motif; other site
543734005208	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
543734005209	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
543734005210	active site
543734005211	phosphorylation site [posttranslational modification]
543734005212	intermolecular recognition site; other site
543734005213	dimerization interface [polypeptide binding]; other site
543734005214	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
543734005215	DNA binding site [nucleotide binding]
543734005216	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
543734005217	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
543734005218	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
543734005219	Protein of unknown function (DUF3781); Region: DUF3781; pfam12636
543734005220	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
543734005221	hypothetical protein; Provisional; Region: PRK13670
543734005222	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
543734005223	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
543734005224	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
543734005225	S-adenosylmethionine binding site [chemical binding]; other site
543734005226	Oligomerisation domain; Region: Oligomerisation; pfam02410
543734005227	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
543734005228	Zn2+ binding site [ion binding]; other site
543734005229	Mg2+ binding site [ion binding]; other site
543734005230	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
543734005231	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
543734005232	active site
543734005233	(T/H)XGH motif; other site
543734005234	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
543734005235	GTPase YqeH; Provisional; Region: PRK13796
543734005236	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
543734005237	GTP/Mg2+ binding site [chemical binding]; other site
543734005238	G4 box; other site
543734005239	G5 box; other site
543734005240	G1 box; other site
543734005241	Switch I region; other site
543734005242	G2 box; other site
543734005243	G3 box; other site
543734005244	Switch II region; other site
543734005245	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
543734005246	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734005247	active site
543734005248	motif I; other site
543734005249	motif II; other site
543734005250	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
543734005251	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
543734005252	Zn binding site [ion binding]; other site
543734005253	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
543734005254	Zn binding site [ion binding]; other site
543734005255	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
543734005256	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
543734005257	Zn binding site [ion binding]; other site
543734005258	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
543734005259	Zn binding site [ion binding]; other site
543734005260	Predicted esterase [General function prediction only]; Region: COG0400
543734005261	putative hydrolase; Provisional; Region: PRK11460
543734005262	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
543734005263	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
543734005264	putative NAD(P) binding site [chemical binding]; other site
543734005265	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
543734005266	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
543734005267	23S rRNA binding site [nucleotide binding]; other site
543734005268	L21 binding site [polypeptide binding]; other site
543734005269	L13 binding site [polypeptide binding]; other site
543734005270	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
543734005271	translation initiation factor IF-3; Region: infC; TIGR00168
543734005272	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
543734005273	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
543734005274	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
543734005275	catalytic core [active]
543734005276	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
543734005277	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
543734005278	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
543734005279	active site
543734005280	dimer interface [polypeptide binding]; other site
543734005281	motif 1; other site
543734005282	motif 2; other site
543734005283	motif 3; other site
543734005284	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
543734005285	anticodon binding site; other site
543734005286	primosomal protein DnaI; Reviewed; Region: PRK08939
543734005287	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
543734005288	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
543734005289	Walker A motif; other site
543734005290	ATP binding site [chemical binding]; other site
543734005291	Walker B motif; other site
543734005292	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
543734005293	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
543734005294	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
543734005295	ATP cone domain; Region: ATP-cone; pfam03477
543734005296	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
543734005297	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
543734005298	CoA-binding site [chemical binding]; other site
543734005299	ATP-binding [chemical binding]; other site
543734005300	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
543734005301	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
543734005302	DNA binding site [nucleotide binding]
543734005303	catalytic residue [active]
543734005304	H2TH interface [polypeptide binding]; other site
543734005305	putative catalytic residues [active]
543734005306	turnover-facilitating residue; other site
543734005307	intercalation triad [nucleotide binding]; other site
543734005308	8OG recognition residue [nucleotide binding]; other site
543734005309	putative reading head residues; other site
543734005310	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
543734005311	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
543734005312	DNA polymerase I; Provisional; Region: PRK05755
543734005313	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
543734005314	active site
543734005315	metal binding site 1 [ion binding]; metal-binding site
543734005316	putative 5' ssDNA interaction site; other site
543734005317	metal binding site 3; metal-binding site
543734005318	metal binding site 2 [ion binding]; metal-binding site
543734005319	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
543734005320	putative DNA binding site [nucleotide binding]; other site
543734005321	putative metal binding site [ion binding]; other site
543734005322	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
543734005323	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
543734005324	active site
543734005325	DNA binding site [nucleotide binding]
543734005326	catalytic site [active]
543734005327	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
543734005328	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
543734005329	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
543734005330	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
543734005331	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
543734005332	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
543734005333	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
543734005334	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
543734005335	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
543734005336	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
543734005337	putative tRNA-binding site [nucleotide binding]; other site
543734005338	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
543734005339	catalytic residues [active]
543734005340	Predicted small secreted protein [Function unknown]; Region: COG5584
543734005341	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
543734005342	S-adenosylmethionine binding site [chemical binding]; other site
543734005343	potential protein location (hypothetical protein) that overlaps protein (tRNA (guanine-N(7)-)-methyltransferase)
543734005344	Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510
543734005345	Phosphotransferase enzyme family; Region: APH; pfam01636
543734005346	substrate binding site [chemical binding]; other site
543734005347	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
543734005348	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
543734005349	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
543734005350	Walker A/P-loop; other site
543734005351	ATP binding site [chemical binding]; other site
543734005352	Q-loop/lid; other site
543734005353	ABC transporter signature motif; other site
543734005354	Walker B; other site
543734005355	D-loop; other site
543734005356	H-loop/switch region; other site
543734005357	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
543734005358	HIT family signature motif; other site
543734005359	catalytic residue [active]
543734005360	YtxH-like protein; Region: YtxH; pfam12732
543734005361	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
543734005362	SurA N-terminal domain; Region: SurA_N_3; cl07813
543734005363	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
543734005364	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
543734005365	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
543734005366	generic binding surface I; other site
543734005367	generic binding surface II; other site
543734005368	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
543734005369	Zn2+ binding site [ion binding]; other site
543734005370	Mg2+ binding site [ion binding]; other site
543734005371	Protein of unknown function (DUF964); Region: DUF964; cl01483
543734005372	Transglycosylase; Region: Transgly; pfam00912
543734005373	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
543734005374	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
543734005375	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
543734005376	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
543734005377	active site
543734005378	Arginine repressor [Transcription]; Region: ArgR; COG1438
543734005379	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
543734005380	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
543734005381	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
543734005382	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
543734005383	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
543734005384	active site
543734005385	HIGH motif; other site
543734005386	KMSK motif region; other site
543734005387	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
543734005388	tRNA binding surface [nucleotide binding]; other site
543734005389	anticodon binding site; other site
543734005390	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
543734005391	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
543734005392	active site
543734005393	FMN binding site [chemical binding]; other site
543734005394	substrate binding site [chemical binding]; other site
543734005395	catalytic residues [active]
543734005396	homodimer interface [polypeptide binding]; other site
543734005397	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110
543734005398	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
543734005399	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
543734005400	putative active site [active]
543734005401	catalytic site [active]
543734005402	putative metal binding site [ion binding]; other site
543734005403	adaptor protein; Provisional; Region: PRK02315
543734005404	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
543734005405	ArsC family; Region: ArsC; pfam03960
543734005406	putative catalytic residues [active]
543734005407	thiol/disulfide switch; other site
543734005408	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
543734005409	FtsX-like permease family; Region: FtsX; pfam02687
543734005410	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
543734005411	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
543734005412	Walker A/P-loop; other site
543734005413	ATP binding site [chemical binding]; other site
543734005414	Q-loop/lid; other site
543734005415	ABC transporter signature motif; other site
543734005416	Walker B; other site
543734005417	D-loop; other site
543734005418	H-loop/switch region; other site
543734005419	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
543734005420	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
543734005421	active site
543734005422	phosphorylation site [posttranslational modification]
543734005423	intermolecular recognition site; other site
543734005424	dimerization interface [polypeptide binding]; other site
543734005425	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
543734005426	DNA binding site [nucleotide binding]
543734005427	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
543734005428	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
543734005429	ATP binding site [chemical binding]; other site
543734005430	Mg2+ binding site [ion binding]; other site
543734005431	G-X-G motif; other site
543734005432	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
543734005433	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
543734005434	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
543734005435	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
543734005436	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
543734005437	Penicillinase repressor; Region: Pencillinase_R; pfam03965
543734005438	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
543734005439	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
543734005440	ATP-grasp domain; Region: ATP-grasp_4; cl17255
543734005441	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
543734005442	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
543734005443	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
543734005444	purine monophosphate binding site [chemical binding]; other site
543734005445	dimer interface [polypeptide binding]; other site
543734005446	putative catalytic residues [active]
543734005447	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
543734005448	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
543734005449	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
543734005450	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
543734005451	active site
543734005452	substrate binding site [chemical binding]; other site
543734005453	cosubstrate binding site; other site
543734005454	catalytic site [active]
543734005455	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
543734005456	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
543734005457	dimerization interface [polypeptide binding]; other site
543734005458	putative ATP binding site [chemical binding]; other site
543734005459	amidophosphoribosyltransferase; Provisional; Region: PRK07272
543734005460	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
543734005461	active site
543734005462	tetramer interface [polypeptide binding]; other site
543734005463	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
543734005464	active site
543734005465	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
543734005466	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
543734005467	dimerization interface [polypeptide binding]; other site
543734005468	ATP binding site [chemical binding]; other site
543734005469	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
543734005470	dimerization interface [polypeptide binding]; other site
543734005471	ATP binding site [chemical binding]; other site
543734005472	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
543734005473	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
543734005474	putative active site [active]
543734005475	catalytic triad [active]
543734005476	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
543734005477	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
543734005478	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
543734005479	ATP binding site [chemical binding]; other site
543734005480	active site
543734005481	substrate binding site [chemical binding]; other site
543734005482	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
543734005483	ATP-grasp domain; Region: ATP-grasp; pfam02222
543734005484	AIR carboxylase; Region: AIRC; pfam00731
543734005485	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515
543734005486	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
543734005487	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734005488	putative substrate translocation pore; other site
543734005489	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734005490	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
543734005491	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
543734005492	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
543734005493	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
543734005494	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
543734005495	dimerization domain swap beta strand [polypeptide binding]; other site
543734005496	regulatory protein interface [polypeptide binding]; other site
543734005497	active site
543734005498	regulatory phosphorylation site [posttranslational modification]; other site
543734005499	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
543734005500	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
543734005501	Walker A motif; other site
543734005502	ATP binding site [chemical binding]; other site
543734005503	Walker B motif; other site
543734005504	arginine finger; other site
543734005505	UvrB/uvrC motif; Region: UVR; pfam02151
543734005506	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
543734005507	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
543734005508	Walker A motif; other site
543734005509	ATP binding site [chemical binding]; other site
543734005510	Walker B motif; other site
543734005511	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
543734005512	Domain of unknown function (DUF1827); Region: DUF1827; pfam08860
543734005513	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
543734005514	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
543734005515	G1 box; other site
543734005516	putative GEF interaction site [polypeptide binding]; other site
543734005517	GTP/Mg2+ binding site [chemical binding]; other site
543734005518	Switch I region; other site
543734005519	G2 box; other site
543734005520	G3 box; other site
543734005521	Switch II region; other site
543734005522	G4 box; other site
543734005523	G5 box; other site
543734005524	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
543734005525	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
543734005526	Domain of unknown function DUF21; Region: DUF21; pfam01595
543734005527	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
543734005528	Transporter associated domain; Region: CorC_HlyC; pfam03471
543734005529	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
543734005530	Domain of unknown function DUF20; Region: UPF0118; pfam01594
543734005531	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
543734005532	Coenzyme A binding pocket [chemical binding]; other site
543734005533	hypothetical protein; Provisional; Region: PRK13662
543734005534	RecX family; Region: RecX; cl00936
543734005535	Mga helix-turn-helix domain; Region: Mga; pfam05043
543734005536	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
543734005537	TRAM domain; Region: TRAM; pfam01938
543734005538	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
543734005539	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
543734005540	S-adenosylmethionine binding site [chemical binding]; other site
543734005541	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
543734005542	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
543734005543	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
543734005544	DNA-binding site [nucleotide binding]; DNA binding site
543734005545	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
543734005546	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
543734005547	beta-galactosidase; Region: BGL; TIGR03356
543734005548	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
543734005549	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
543734005550	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
543734005551	active site
543734005552	methionine cluster; other site
543734005553	phosphorylation site [posttranslational modification]
543734005554	metal binding site [ion binding]; metal-binding site
543734005555	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
543734005556	active site
543734005557	P-loop; other site
543734005558	phosphorylation site [posttranslational modification]
543734005559	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
543734005560	pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720
543734005561	PYR/PP interface [polypeptide binding]; other site
543734005562	dimer interface [polypeptide binding]; other site
543734005563	tetramer interface [polypeptide binding]; other site
543734005564	TPP binding site [chemical binding]; other site
543734005565	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
543734005566	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
543734005567	TPP-binding site [chemical binding]; other site
543734005568	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
543734005569	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
543734005570	dimer interface [polypeptide binding]; other site
543734005571	active site
543734005572	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
543734005573	homodimer interface [polypeptide binding]; other site
543734005574	catalytic residues [active]
543734005575	NAD binding site [chemical binding]; other site
543734005576	substrate binding pocket [chemical binding]; other site
543734005577	flexible flap; other site
543734005578	putative acyltransferase; Provisional; Region: PRK05790
543734005579	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
543734005580	dimer interface [polypeptide binding]; other site
543734005581	active site
543734005582	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
543734005583	Restriction endonuclease; Region: Mrr_cat; pfam04471
543734005584	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
543734005585	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
543734005586	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
543734005587	metal binding site [ion binding]; metal-binding site
543734005588	dimer interface [polypeptide binding]; other site
543734005589	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
543734005590	Predicted membrane protein [Function unknown]; Region: COG4684
543734005591	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
543734005592	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
543734005593	Coenzyme A binding pocket [chemical binding]; other site
543734005594	hypothetical protein; Provisional; Region: PRK04351
543734005595	SprT homologues; Region: SprT; cl01182
543734005596	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
543734005597	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734005598	Walker A/P-loop; other site
543734005599	ATP binding site [chemical binding]; other site
543734005600	Q-loop/lid; other site
543734005601	ABC transporter signature motif; other site
543734005602	Walker B; other site
543734005603	D-loop; other site
543734005604	H-loop/switch region; other site
543734005605	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
543734005606	TM-ABC transporter signature motif; other site
543734005607	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
543734005608	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
543734005609	zinc binding site [ion binding]; other site
543734005610	putative ligand binding site [chemical binding]; other site
543734005611	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
543734005612	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
543734005613	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
543734005614	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
543734005615	Soluble P-type ATPase [General function prediction only]; Region: COG4087
543734005616	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
543734005617	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
543734005618	Beta-lactamase; Region: Beta-lactamase; pfam00144
543734005619	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
543734005620	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
543734005621	homodimer interface [polypeptide binding]; other site
543734005622	NAD binding pocket [chemical binding]; other site
543734005623	ATP binding pocket [chemical binding]; other site
543734005624	Mg binding site [ion binding]; other site
543734005625	active-site loop [active]
543734005626	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
543734005627	Beta-lactamase; Region: Beta-lactamase; pfam00144
543734005628	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
543734005629	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
543734005630	active site
543734005631	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
543734005632	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
543734005633	DNA-binding site [nucleotide binding]; DNA binding site
543734005634	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
543734005635	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
543734005636	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
543734005637	active site
543734005638	dimer interface [polypeptide binding]; other site
543734005639	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
543734005640	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
543734005641	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
543734005642	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
543734005643	potential protein location (hypothetical protein LCABL_20320 [lactobacillus casei BL23]) that overlaps RNA (tRNA-Y)
543734005644	putative phosphoesterase; Region: acc_ester; TIGR03729
543734005645	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
543734005646	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
543734005647	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734005648	putative substrate translocation pore; other site
543734005649	POT family; Region: PTR2; pfam00854
543734005650	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
543734005651	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
543734005652	Walker A/P-loop; other site
543734005653	ATP binding site [chemical binding]; other site
543734005654	Q-loop/lid; other site
543734005655	ABC transporter signature motif; other site
543734005656	Walker B; other site
543734005657	D-loop; other site
543734005658	H-loop/switch region; other site
543734005659	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
543734005660	FtsX-like permease family; Region: FtsX; pfam02687
543734005661	MFS/sugar transport protein; Region: MFS_2; pfam13347
543734005662	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
543734005663	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
543734005664	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
543734005665	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
543734005666	catalytic residues [active]
543734005667	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
543734005668	active site
543734005669	nucleotide-binding site [chemical binding]; other site
543734005670	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
543734005671	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
543734005672	G1 box; other site
543734005673	GTP/Mg2+ binding site [chemical binding]; other site
543734005674	Switch I region; other site
543734005675	G2 box; other site
543734005676	G3 box; other site
543734005677	Switch II region; other site
543734005678	G4 box; other site
543734005679	G5 box; other site
543734005680	Nucleoside recognition; Region: Gate; pfam07670
543734005681	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
543734005682	Nucleoside recognition; Region: Gate; pfam07670
543734005683	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
543734005684	FeoA domain; Region: FeoA; cl00838
543734005685	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
543734005686	catalytic triad [active]
543734005687	catalytic triad [active]
543734005688	oxyanion hole [active]
543734005689	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
543734005690	NADH(P)-binding; Region: NAD_binding_10; pfam13460
543734005691	NAD binding site [chemical binding]; other site
543734005692	substrate binding site [chemical binding]; other site
543734005693	putative active site [active]
543734005694	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
543734005695	Domain of unknown function (DUF4330); Region: DUF4330; pfam14221
543734005696	seryl-tRNA synthetase; Provisional; Region: PRK05431
543734005697	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
543734005698	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
543734005699	dimer interface [polypeptide binding]; other site
543734005700	active site
543734005701	motif 1; other site
543734005702	motif 2; other site
543734005703	motif 3; other site
543734005704	Mga helix-turn-helix domain; Region: Mga; pfam05043
543734005705	Mga helix-turn-helix domain; Region: Mga; pfam05043
543734005706	lysine transporter; Provisional; Region: PRK10836
543734005707	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
543734005708	acetolactate synthase; Reviewed; Region: PRK08617
543734005709	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
543734005710	PYR/PP interface [polypeptide binding]; other site
543734005711	dimer interface [polypeptide binding]; other site
543734005712	TPP binding site [chemical binding]; other site
543734005713	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
543734005714	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
543734005715	TPP-binding site [chemical binding]; other site
543734005716	dimer interface [polypeptide binding]; other site
543734005717	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
543734005718	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
543734005719	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
543734005720	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
543734005721	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
543734005722	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
543734005723	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
543734005724	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
543734005725	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
543734005726	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
543734005727	active site
543734005728	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
543734005729	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
543734005730	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
543734005731	potential protein location (hypothetical protein) that overlaps protein (Triphosphoribosyl-dephospho-coenzymeA synthase)
543734005732	Transcriptional regulators [Transcription]; Region: GntR; COG1802
543734005733	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
543734005734	DNA-binding site [nucleotide binding]; DNA binding site
543734005735	FCD domain; Region: FCD; pfam07729
543734005736	oxaloacetate decarboxylase; Provisional; Region: PRK12331
543734005737	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
543734005738	active site
543734005739	catalytic residues [active]
543734005740	metal binding site [ion binding]; metal-binding site
543734005741	homodimer binding site [polypeptide binding]; other site
543734005742	2'-(5''-triphosphoribosyl)-3'- dephospho-CoA:apo-citrate lyase; Reviewed; Region: citX; PRK01392
543734005743	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
543734005744	Coenzyme A transferase; Region: CoA_trans; cl17247
543734005745	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
543734005746	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
543734005747	citrate lyase subunit gamma; Provisional; Region: PRK13253
543734005748	[citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124
543734005749	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
543734005750	active site
543734005751	nucleotide binding site [chemical binding]; other site
543734005752	HIGH motif; other site
543734005753	KMSKS motif; other site
543734005754	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
543734005755	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549
543734005756	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
543734005757	carboxyltransferase (CT) interaction site; other site
543734005758	biotinylation site [posttranslational modification]; other site
543734005759	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
543734005760	Citrate transporter; Region: CitMHS; pfam03600
543734005761	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
543734005762	RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885
543734005763	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
543734005764	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
543734005765	Coenzyme A binding pocket [chemical binding]; other site
543734005766	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
543734005767	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
543734005768	Predicted transcriptional regulators [Transcription]; Region: COG1695
543734005769	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
543734005770	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
543734005771	dimer interface [polypeptide binding]; other site
543734005772	FMN binding site [chemical binding]; other site
543734005773	NADPH bind site [chemical binding]; other site
543734005774	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
543734005775	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
543734005776	Walker A/P-loop; other site
543734005777	ATP binding site [chemical binding]; other site
543734005778	Q-loop/lid; other site
543734005779	ABC transporter signature motif; other site
543734005780	Walker B; other site
543734005781	D-loop; other site
543734005782	H-loop/switch region; other site
543734005783	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
543734005784	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
543734005785	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
543734005786	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734005787	Major Facilitator Superfamily; Region: MFS_1; pfam07690
543734005788	putative substrate translocation pore; other site
543734005789	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734005790	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
543734005791	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
543734005792	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734005793	non-specific DNA binding site [nucleotide binding]; other site
543734005794	salt bridge; other site
543734005795	sequence-specific DNA binding site [nucleotide binding]; other site
543734005796	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
543734005797	Predicted transcriptional regulators [Transcription]; Region: COG1725
543734005798	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
543734005799	DNA-binding site [nucleotide binding]; DNA binding site
543734005800	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
543734005801	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734005802	Walker A/P-loop; other site
543734005803	ATP binding site [chemical binding]; other site
543734005804	Q-loop/lid; other site
543734005805	ABC transporter signature motif; other site
543734005806	Walker B; other site
543734005807	D-loop; other site
543734005808	H-loop/switch region; other site
543734005809	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
543734005810	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
543734005811	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
543734005812	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
543734005813	Walker A/P-loop; other site
543734005814	ATP binding site [chemical binding]; other site
543734005815	Q-loop/lid; other site
543734005816	ABC transporter signature motif; other site
543734005817	Walker B; other site
543734005818	D-loop; other site
543734005819	H-loop/switch region; other site
543734005820	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
543734005821	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
543734005822	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
543734005823	Walker A/P-loop; other site
543734005824	ATP binding site [chemical binding]; other site
543734005825	Q-loop/lid; other site
543734005826	ABC transporter signature motif; other site
543734005827	Walker B; other site
543734005828	D-loop; other site
543734005829	H-loop/switch region; other site
543734005830	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
543734005831	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
543734005832	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734005833	dimer interface [polypeptide binding]; other site
543734005834	conserved gate region; other site
543734005835	putative PBP binding loops; other site
543734005836	ABC-ATPase subunit interface; other site
543734005837	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
543734005838	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734005839	dimer interface [polypeptide binding]; other site
543734005840	conserved gate region; other site
543734005841	putative PBP binding loops; other site
543734005842	ABC-ATPase subunit interface; other site
543734005843	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
543734005844	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
543734005845	peptide binding site [polypeptide binding]; other site
543734005846	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
543734005847	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
543734005848	potential catalytic triad [active]
543734005849	conserved cys residue [active]
543734005850	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
543734005851	putative DNA binding site [nucleotide binding]; other site
543734005852	putative Zn2+ binding site [ion binding]; other site
543734005853	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
543734005854	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
543734005855	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734005856	Walker A/P-loop; other site
543734005857	ATP binding site [chemical binding]; other site
543734005858	Q-loop/lid; other site
543734005859	ABC transporter signature motif; other site
543734005860	Walker B; other site
543734005861	D-loop; other site
543734005862	H-loop/switch region; other site
543734005863	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
543734005864	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
543734005865	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
543734005866	Walker A/P-loop; other site
543734005867	ATP binding site [chemical binding]; other site
543734005868	Q-loop/lid; other site
543734005869	ABC transporter signature motif; other site
543734005870	Walker B; other site
543734005871	D-loop; other site
543734005872	H-loop/switch region; other site
543734005873	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
543734005874	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
543734005875	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
543734005876	active site
543734005877	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
543734005878	Helix-turn-helix domain; Region: HTH_38; pfam13936
543734005879	Integrase core domain; Region: rve; pfam00665
543734005880	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
543734005881	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
543734005882	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
543734005883	SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133
543734005884	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
543734005885	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734005886	non-specific DNA binding site [nucleotide binding]; other site
543734005887	salt bridge; other site
543734005888	sequence-specific DNA binding site [nucleotide binding]; other site
543734005889	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
543734005890	Homeodomain-like domain; Region: HTH_23; cl17451
543734005891	Transposase; Region: DDE_Tnp_ISL3; pfam01610
543734005892	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
543734005893	Transposase; Region: DDE_Tnp_ISL3; pfam01610
543734005894	Integrase core domain; Region: rve; pfam00665
543734005895	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
543734005896	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
543734005897	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
543734005898	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
543734005899	Helix-turn-helix domain; Region: HTH_38; pfam13936
543734005900	Integrase core domain; Region: rve; pfam00665
543734005901	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
543734005902	Transposase; Region: HTH_Tnp_1; pfam01527
543734005903	HTH-like domain; Region: HTH_21; pfam13276
543734005904	Integrase core domain; Region: rve; pfam00665
543734005905	Integrase core domain; Region: rve_3; pfam13683
543734005906	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
543734005907	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
543734005908	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
543734005909	Cl binding site [ion binding]; other site
543734005910	oligomer interface [polypeptide binding]; other site
543734005911	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
543734005912	Helix-turn-helix domain; Region: HTH_38; pfam13936
543734005913	Integrase core domain; Region: rve; pfam00665
543734005914	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
543734005915	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
543734005916	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_2; cd08769
543734005917	SxDxEG motif; other site
543734005918	putative active site [active]
543734005919	putative metal binding site [ion binding]; other site
543734005920	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
543734005921	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
543734005922	oligomer interface [polypeptide binding]; other site
543734005923	active site
543734005924	metal binding site [ion binding]; metal-binding site
543734005925	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
543734005926	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
543734005927	peptide binding site [polypeptide binding]; other site
543734005928	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
543734005929	Integrase core domain; Region: rve; pfam00665
543734005930	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
543734005931	Helix-turn-helix domain; Region: HTH_16; pfam12645
543734005932	PAZ domain, named PAZ after the proteins Piwi Argonaut and Zwille. PAZ is found in two families of proteins that are essential components of RNA-mediated gene-silencing pathways, including RNA interference, the piwi and Dicer families. PAZ functions as a...; Region: PAZ; cl00301
543734005933	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
543734005934	nucleic acid-binding interface [nucleotide binding]; other site
543734005935	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
543734005936	Int/Topo IB signature motif; other site
543734005937	GMP synthase; Reviewed; Region: guaA; PRK00074
543734005938	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
543734005939	AMP/PPi binding site [chemical binding]; other site
543734005940	candidate oxyanion hole; other site
543734005941	catalytic triad [active]
543734005942	potential glutamine specificity residues [chemical binding]; other site
543734005943	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
543734005944	ATP Binding subdomain [chemical binding]; other site
543734005945	Dimerization subdomain; other site
543734005946	pantothenate kinase; Provisional; Region: PRK05439
543734005947	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
543734005948	ATP-binding site [chemical binding]; other site
543734005949	CoA-binding site [chemical binding]; other site
543734005950	Mg2+-binding site [ion binding]; other site
543734005951	Peptidase family C69; Region: Peptidase_C69; pfam03577
543734005952	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
543734005953	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
543734005954	Part of AAA domain; Region: AAA_19; pfam13245
543734005955	Family description; Region: UvrD_C_2; pfam13538
543734005956	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
543734005957	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
543734005958	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
543734005959	TrkA-C domain; Region: TrkA_C; pfam02080
543734005960	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
543734005961	manganese transport protein MntH; Reviewed; Region: PRK00701
543734005962	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
543734005963	Ferrochelatase; Region: Ferrochelatase; pfam00762
543734005964	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
543734005965	C-terminal domain interface [polypeptide binding]; other site
543734005966	active site
543734005967	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
543734005968	active site
543734005969	N-terminal domain interface [polypeptide binding]; other site
543734005970	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
543734005971	catalytic core [active]
543734005972	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
543734005973	FtsX-like permease family; Region: FtsX; pfam02687
543734005974	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
543734005975	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
543734005976	Walker A/P-loop; other site
543734005977	ATP binding site [chemical binding]; other site
543734005978	Q-loop/lid; other site
543734005979	ABC transporter signature motif; other site
543734005980	Walker B; other site
543734005981	D-loop; other site
543734005982	H-loop/switch region; other site
543734005983	Amino acid permease; Region: AA_permease_2; pfam13520
543734005984	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
543734005985	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
543734005986	hypothetical protein
543734005987	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
543734005988	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
543734005989	HflX GTPase family; Region: HflX; cd01878
543734005990	G1 box; other site
543734005991	GTP/Mg2+ binding site [chemical binding]; other site
543734005992	Switch I region; other site
543734005993	G2 box; other site
543734005994	G3 box; other site
543734005995	Switch II region; other site
543734005996	G4 box; other site
543734005997	G5 box; other site
543734005998	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
543734005999	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
543734006000	NodB motif; other site
543734006001	active site
543734006002	catalytic site [active]
543734006003	Zn binding site [ion binding]; other site
543734006004	Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264
543734006005	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
543734006006	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
543734006007	putative active site [active]
543734006008	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
543734006009	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
543734006010	NADP binding site [chemical binding]; other site
543734006011	active site
543734006012	putative substrate binding site [chemical binding]; other site
543734006013	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
543734006014	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
543734006015	NAD binding site [chemical binding]; other site
543734006016	substrate binding site [chemical binding]; other site
543734006017	homodimer interface [polypeptide binding]; other site
543734006018	active site
543734006019	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
543734006020	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
543734006021	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
543734006022	substrate binding site; other site
543734006023	tetramer interface; other site
543734006024	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
543734006025	Bacterial sugar transferase; Region: Bac_transf; pfam02397
543734006026	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
543734006027	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
543734006028	NAD(P) binding site [chemical binding]; other site
543734006029	active site
543734006030	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
543734006031	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734006032	dimer interface [polypeptide binding]; other site
543734006033	conserved gate region; other site
543734006034	putative PBP binding loops; other site
543734006035	ABC-ATPase subunit interface; other site
543734006036	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
543734006037	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734006038	dimer interface [polypeptide binding]; other site
543734006039	conserved gate region; other site
543734006040	putative PBP binding loops; other site
543734006041	ABC-ATPase subunit interface; other site
543734006042	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
543734006043	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
543734006044	substrate binding pocket [chemical binding]; other site
543734006045	membrane-bound complex binding site; other site
543734006046	hinge residues; other site
543734006047	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
543734006048	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
543734006049	Walker A/P-loop; other site
543734006050	ATP binding site [chemical binding]; other site
543734006051	Q-loop/lid; other site
543734006052	ABC transporter signature motif; other site
543734006053	Walker B; other site
543734006054	D-loop; other site
543734006055	H-loop/switch region; other site
543734006056	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
543734006057	metal binding site 2 [ion binding]; metal-binding site
543734006058	putative DNA binding helix; other site
543734006059	metal binding site 1 [ion binding]; metal-binding site
543734006060	dimer interface [polypeptide binding]; other site
543734006061	structural Zn2+ binding site [ion binding]; other site
543734006062	Guanylate kinase; Region: Guanylate_kin; pfam00625
543734006063	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
543734006064	active site
543734006065	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
543734006066	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
543734006067	Coenzyme A binding pocket [chemical binding]; other site
543734006068	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
543734006069	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
543734006070	NlpC/P60 family; Region: NLPC_P60; pfam00877
543734006071	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
543734006072	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
543734006073	active site
543734006074	HIGH motif; other site
543734006075	dimer interface [polypeptide binding]; other site
543734006076	KMSKS motif; other site
543734006077	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
543734006078	RNA binding surface [nucleotide binding]; other site
543734006079	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
543734006080	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
543734006081	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
543734006082	dimerization interface [polypeptide binding]; other site
543734006083	putative DNA binding site [nucleotide binding]; other site
543734006084	putative Zn2+ binding site [ion binding]; other site
543734006085	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
543734006086	ApbE family; Region: ApbE; pfam02424
543734006087	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
543734006088	active site
543734006089	homodimer interface [polypeptide binding]; other site
543734006090	catalytic site [active]
543734006091	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
543734006092	homodimer interface [polypeptide binding]; other site
543734006093	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
543734006094	active site pocket [active]
543734006095	glycogen synthase; Provisional; Region: glgA; PRK00654
543734006096	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
543734006097	ADP-binding pocket [chemical binding]; other site
543734006098	homodimer interface [polypeptide binding]; other site
543734006099	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
543734006100	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
543734006101	active site
543734006102	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
543734006103	dimer interface [polypeptide binding]; other site
543734006104	N-terminal domain interface [polypeptide binding]; other site
543734006105	sulfate 1 binding site; other site
543734006106	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
543734006107	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
543734006108	ligand binding site; other site
543734006109	oligomer interface; other site
543734006110	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
543734006111	dimer interface [polypeptide binding]; other site
543734006112	N-terminal domain interface [polypeptide binding]; other site
543734006113	sulfate 1 binding site; other site
543734006114	glycogen branching enzyme; Provisional; Region: PRK12313
543734006115	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
543734006116	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
543734006117	active site
543734006118	catalytic site [active]
543734006119	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
543734006120	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
543734006121	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
543734006122	homodimer interface [polypeptide binding]; other site
543734006123	substrate-cofactor binding pocket; other site
543734006124	catalytic residue [active]
543734006125	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
543734006126	Uncharacterized conserved protein [Function unknown]; Region: COG1284
543734006127	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
543734006128	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
543734006129	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
543734006130	ArsC family; Region: ArsC; pfam03960
543734006131	putative catalytic residues [active]
543734006132	thiol/disulfide switch; other site
543734006133	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
543734006134	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
543734006135	Walker A motif; other site
543734006136	ATP binding site [chemical binding]; other site
543734006137	Walker B motif; other site
543734006138	arginine finger; other site
543734006139	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
543734006140	Walker A motif; other site
543734006141	ATP binding site [chemical binding]; other site
543734006142	Walker B motif; other site
543734006143	arginine finger; other site
543734006144	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
543734006145	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
543734006146	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
543734006147	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
543734006148	Transposase; Region: DDE_Tnp_ISL3; pfam01610
543734006149	Transposase domain (DUF772); Region: DUF772; pfam05598
543734006150	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
543734006151	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
543734006152	Homeodomain-like domain; Region: HTH_23; pfam13384
543734006153	Transposase; Region: DDE_Tnp_ISL3; pfam01610
543734006154	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
543734006155	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
543734006156	NADP binding site [chemical binding]; other site
543734006157	active site
543734006158	putative substrate binding site [chemical binding]; other site
543734006159	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
543734006160	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
543734006161	NAD binding site [chemical binding]; other site
543734006162	substrate binding site [chemical binding]; other site
543734006163	homodimer interface [polypeptide binding]; other site
543734006164	active site
543734006165	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
543734006166	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
543734006167	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
543734006168	substrate binding site; other site
543734006169	tetramer interface; other site
543734006170	Bacterial sugar transferase; Region: Bac_transf; pfam02397
543734006171	Transposase domain (DUF772); Region: DUF772; pfam05598
543734006172	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
543734006173	Bacterial sugar transferase; Region: Bac_transf; cl00939
543734006174	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
543734006175	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
543734006176	active site
543734006177	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
543734006178	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
543734006179	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
543734006180	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
543734006181	trimer interface [polypeptide binding]; other site
543734006182	active site
543734006183	substrate binding site [chemical binding]; other site
543734006184	CoA binding site [chemical binding]; other site
543734006185	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
543734006186	active site
543734006187	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
543734006188	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
543734006189	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
543734006190	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
543734006191	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
543734006192	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
543734006193	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
543734006194	Chain length determinant protein; Region: Wzz; cl15801
543734006195	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
543734006196	catalytic triad [active]
543734006197	catalytic triad [active]
543734006198	oxyanion hole [active]
543734006199	QueT transporter; Region: QueT; pfam06177
543734006200	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
543734006201	classical (c) SDRs; Region: SDR_c; cd05233
543734006202	NAD(P) binding site [chemical binding]; other site
543734006203	active site
543734006204	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
543734006205	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
543734006206	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734006207	non-specific DNA binding site [nucleotide binding]; other site
543734006208	salt bridge; other site
543734006209	sequence-specific DNA binding site [nucleotide binding]; other site
543734006210	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
543734006211	catalytic core [active]
543734006212	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
543734006213	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
543734006214	Walker A/P-loop; other site
543734006215	ATP binding site [chemical binding]; other site
543734006216	Q-loop/lid; other site
543734006217	ABC transporter signature motif; other site
543734006218	Walker B; other site
543734006219	D-loop; other site
543734006220	H-loop/switch region; other site
543734006221	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
543734006222	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
543734006223	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
543734006224	Walker A/P-loop; other site
543734006225	ATP binding site [chemical binding]; other site
543734006226	Q-loop/lid; other site
543734006227	ABC transporter signature motif; other site
543734006228	Walker B; other site
543734006229	D-loop; other site
543734006230	H-loop/switch region; other site
543734006231	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
543734006232	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
543734006233	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
543734006234	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734006235	dimer interface [polypeptide binding]; other site
543734006236	conserved gate region; other site
543734006237	putative PBP binding loops; other site
543734006238	ABC-ATPase subunit interface; other site
543734006239	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
543734006240	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734006241	dimer interface [polypeptide binding]; other site
543734006242	conserved gate region; other site
543734006243	putative PBP binding loops; other site
543734006244	ABC-ATPase subunit interface; other site
543734006245	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
543734006246	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
543734006247	peptide binding site [polypeptide binding]; other site
543734006248	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
543734006249	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734006250	putative substrate translocation pore; other site
543734006251	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
543734006252	Helix-turn-helix domain; Region: HTH_38; pfam13936
543734006253	Integrase core domain; Region: rve; pfam00665
543734006254	elongation factor P; Validated; Region: PRK00529
543734006255	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
543734006256	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
543734006257	RNA binding site [nucleotide binding]; other site
543734006258	Elongation factor P, C-terminal; Region: Elong-fact-P_C; pfam09285
543734006259	RNA binding site [nucleotide binding]; other site
543734006260	Uncharacterized conserved protein [Function unknown]; Region: COG1556
543734006261	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
543734006262	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
543734006263	4Fe-4S binding domain; Region: Fer4; pfam00037
543734006264	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
543734006265	Cysteine-rich domain; Region: CCG; pfam02754
543734006266	Cysteine-rich domain; Region: CCG; pfam02754
543734006267	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
543734006268	active site
543734006269	methionine cluster; other site
543734006270	phosphorylation site [posttranslational modification]
543734006271	metal binding site [ion binding]; metal-binding site
543734006272	Uncharacterized conserved protein [Function unknown]; Region: COG3589
543734006273	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
543734006274	Domain of unknown function (DUF3284); Region: DUF3284; pfam11687
543734006275	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
543734006276	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
543734006277	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
543734006278	Melibiase; Region: Melibiase; pfam02065
543734006279	hypothetical protein; Validated; Region: PRK02101
543734006280	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
543734006281	DNA binding residues [nucleotide binding]
543734006282	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
543734006283	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
543734006284	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
543734006285	AAA domain; Region: AAA_30; pfam13604
543734006286	Family description; Region: UvrD_C_2; pfam13538
543734006287	WxL domain surface cell wall-binding; Region: WxL; pfam13731
543734006288	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
543734006289	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
543734006290	substrate binding site [chemical binding]; other site
543734006291	ATP binding site [chemical binding]; other site
543734006292	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
543734006293	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
543734006294	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
543734006295	Uncharacterized conserved protein [Function unknown]; Region: COG3535
543734006296	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
543734006297	Na binding site [ion binding]; other site
543734006298	Protein of unknown function DUF262; Region: DUF262; pfam03235
543734006299	Uncharacterized conserved protein [Function unknown]; Region: COG1479
543734006300	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
543734006301	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
543734006302	Int/Topo IB signature motif; other site
543734006303	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
543734006304	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
543734006305	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
543734006306	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
543734006307	Methyltransferase domain; Region: Methyltransf_26; pfam13659
543734006308	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
543734006309	HsdM N-terminal domain; Region: HsdM_N; pfam12161
543734006310	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
543734006311	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
543734006312	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
543734006313	ATP binding site [chemical binding]; other site
543734006314	putative Mg++ binding site [ion binding]; other site
543734006315	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
543734006316	Protein of unknown function (DUF998); Region: DUF998; pfam06197
543734006317	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
543734006318	HPr interaction site; other site
543734006319	glycerol kinase (GK) interaction site [polypeptide binding]; other site
543734006320	active site
543734006321	phosphorylation site [posttranslational modification]
543734006322	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
543734006323	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
543734006324	active site turn [active]
543734006325	phosphorylation site [posttranslational modification]
543734006326	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
543734006327	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
543734006328	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
543734006329	Ca binding site [ion binding]; other site
543734006330	active site
543734006331	catalytic site [active]
543734006332	Transcriptional regulators [Transcription]; Region: PurR; COG1609
543734006333	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
543734006334	DNA binding site [nucleotide binding]
543734006335	domain linker motif; other site
543734006336	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
543734006337	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
543734006338	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
543734006339	substrate binding [chemical binding]; other site
543734006340	active site
543734006341	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
543734006342	hypothetical protein
543734006343	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
543734006344	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
543734006345	NADP binding site [chemical binding]; other site
543734006346	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
543734006347	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
543734006348	S-adenosylmethionine binding site [chemical binding]; other site
543734006349	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
543734006350	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
543734006351	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
543734006352	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
543734006353	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
543734006354	ATP-grasp domain; Region: ATP-grasp_4; cl17255
543734006355	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
543734006356	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
543734006357	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
543734006358	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
543734006359	carboxyltransferase (CT) interaction site; other site
543734006360	biotinylation site [posttranslational modification]; other site
543734006361	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
543734006362	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
543734006363	dimer interface [polypeptide binding]; other site
543734006364	active site
543734006365	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
543734006366	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
543734006367	NAD(P) binding site [chemical binding]; other site
543734006368	homotetramer interface [polypeptide binding]; other site
543734006369	homodimer interface [polypeptide binding]; other site
543734006370	active site
543734006371	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
543734006372	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
543734006373	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
543734006374	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
543734006375	FMN binding site [chemical binding]; other site
543734006376	substrate binding site [chemical binding]; other site
543734006377	putative catalytic residue [active]
543734006378	acyl carrier protein; Provisional; Region: acpP; PRK00982
543734006379	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
543734006380	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
543734006381	dimer interface [polypeptide binding]; other site
543734006382	active site
543734006383	CoA binding pocket [chemical binding]; other site
543734006384	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
543734006385	MarR family; Region: MarR_2; pfam12802
543734006386	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
543734006387	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
543734006388	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
543734006389	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
543734006390	dimer interface [polypeptide binding]; other site
543734006391	active site
543734006392	metal binding site [ion binding]; metal-binding site
543734006393	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
543734006394	Helix-turn-helix domain; Region: HTH_38; pfam13936
543734006395	Integrase core domain; Region: rve; pfam00665
543734006396	Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078
543734006397	Transcriptional regulators [Transcription]; Region: MarR; COG1846
543734006398	MarR family; Region: MarR_2; pfam12802
543734006399	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
543734006400	S-formylglutathione hydrolase; Region: PLN02442
543734006401	Putative esterase; Region: Esterase; pfam00756
543734006402	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
543734006403	Double zinc ribbon; Region: DZR; pfam12773
543734006404	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
543734006405	putative DNA binding site [nucleotide binding]; other site
543734006406	putative Zn2+ binding site [ion binding]; other site
543734006407	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
543734006408	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
543734006409	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734006410	Walker A/P-loop; other site
543734006411	ATP binding site [chemical binding]; other site
543734006412	Q-loop/lid; other site
543734006413	ABC transporter signature motif; other site
543734006414	Walker B; other site
543734006415	D-loop; other site
543734006416	H-loop/switch region; other site
543734006417	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
543734006418	nudix motif; other site
543734006419	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
543734006420	catalytic core [active]
543734006421	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
543734006422	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
543734006423	Double zinc ribbon; Region: DZR; pfam12773
543734006424	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
543734006425	Beta-lactamase; Region: Beta-lactamase; pfam00144
543734006426	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
543734006427	Domain of unknown function DUF20; Region: UPF0118; pfam01594
543734006428	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
543734006429	active site
543734006430	catalytic site [active]
543734006431	Predicted membrane protein [Function unknown]; Region: COG2246
543734006432	GtrA-like protein; Region: GtrA; pfam04138
543734006433	lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147
543734006434	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
543734006435	Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440
543734006436	pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720
543734006437	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
543734006438	PYR/PP interface [polypeptide binding]; other site
543734006439	dimer interface [polypeptide binding]; other site
543734006440	TPP binding site [chemical binding]; other site
543734006441	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
543734006442	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
543734006443	TPP-binding site [chemical binding]; other site
543734006444	hypothetical protein
543734006445	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
543734006446	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
543734006447	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
543734006448	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734006449	dimer interface [polypeptide binding]; other site
543734006450	conserved gate region; other site
543734006451	putative PBP binding loops; other site
543734006452	ABC-ATPase subunit interface; other site
543734006453	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
543734006454	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
543734006455	Walker A/P-loop; other site
543734006456	ATP binding site [chemical binding]; other site
543734006457	Q-loop/lid; other site
543734006458	ABC transporter signature motif; other site
543734006459	Walker B; other site
543734006460	D-loop; other site
543734006461	H-loop/switch region; other site
543734006462	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
543734006463	DNA-binding protein, stimulates sugar fermentation [General function prediction only]; Region: SfsA; COG1489
543734006464	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
543734006465	Ligand Binding Site [chemical binding]; other site
543734006466	Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919
543734006467	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
543734006468	homoserine kinase; Provisional; Region: PRK01212
543734006469	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
543734006470	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
543734006471	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
543734006472	pyridoxal 5'-phosphate binding site [chemical binding]; other site
543734006473	catalytic residue [active]
543734006474	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
543734006475	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
543734006476	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
543734006477	aspartate kinase; Reviewed; Region: PRK09034
543734006478	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
543734006479	nucleotide binding site [chemical binding]; other site
543734006480	substrate binding site [chemical binding]; other site
543734006481	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
543734006482	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
543734006483	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
543734006484	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
543734006485	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
543734006486	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
543734006487	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
543734006488	homodimer interface [polypeptide binding]; other site
543734006489	ligand binding site [chemical binding]; other site
543734006490	NAD binding site [chemical binding]; other site
543734006491	catalytic site [active]
543734006492	aromatic amino acid aminotransferase; Validated; Region: PRK07309
543734006493	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
543734006494	pyridoxal 5'-phosphate binding site [chemical binding]; other site
543734006495	homodimer interface [polypeptide binding]; other site
543734006496	catalytic residue [active]
543734006497	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
543734006498	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
543734006499	nucleotide binding site/active site [active]
543734006500	HIT family signature motif; other site
543734006501	catalytic residue [active]
543734006502	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
543734006503	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
543734006504	active site
543734006505	dimer interface [polypeptide binding]; other site
543734006506	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
543734006507	Ligand Binding Site [chemical binding]; other site
543734006508	Molecular Tunnel; other site
543734006509	Predicted integral membrane protein [Function unknown]; Region: COG0392
543734006510	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
543734006511	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
543734006512	active site
543734006513	metal binding site [ion binding]; metal-binding site
543734006514	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
543734006515	UbiA prenyltransferase family; Region: UbiA; pfam01040
543734006516	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
543734006517	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
543734006518	substrate binding pocket [chemical binding]; other site
543734006519	chain length determination region; other site
543734006520	substrate-Mg2+ binding site; other site
543734006521	catalytic residues [active]
543734006522	aspartate-rich region 1; other site
543734006523	active site lid residues [active]
543734006524	aspartate-rich region 2; other site
543734006525	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
543734006526	propionate/acetate kinase; Provisional; Region: PRK12379
543734006527	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
543734006528	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734006529	Walker A/P-loop; other site
543734006530	ATP binding site [chemical binding]; other site
543734006531	Q-loop/lid; other site
543734006532	ABC transporter signature motif; other site
543734006533	Walker B; other site
543734006534	D-loop; other site
543734006535	H-loop/switch region; other site
543734006536	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
543734006537	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
543734006538	Predicted transcriptional regulators [Transcription]; Region: COG1725
543734006539	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
543734006540	DNA-binding site [nucleotide binding]; DNA binding site
543734006541	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
543734006542	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
543734006543	Walker A/P-loop; other site
543734006544	ATP binding site [chemical binding]; other site
543734006545	Q-loop/lid; other site
543734006546	ABC transporter signature motif; other site
543734006547	Walker B; other site
543734006548	D-loop; other site
543734006549	H-loop/switch region; other site
543734006550	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
543734006551	glucose-1-dehydrogenase; Provisional; Region: PRK08936
543734006552	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
543734006553	NAD binding site [chemical binding]; other site
543734006554	homodimer interface [polypeptide binding]; other site
543734006555	active site
543734006556	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
543734006557	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
543734006558	hexamer interface [polypeptide binding]; other site
543734006559	ligand binding site [chemical binding]; other site
543734006560	putative active site [active]
543734006561	NAD(P) binding site [chemical binding]; other site
543734006562	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
543734006563	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
543734006564	tetramer interface [polypeptide binding]; other site
543734006565	pyridoxal 5'-phosphate binding site [chemical binding]; other site
543734006566	catalytic residue [active]
543734006567	OPT oligopeptide transporter protein; Region: OPT; cl14607
543734006568	OPT oligopeptide transporter protein; Region: OPT; cl14607
543734006569	OPT oligopeptide transporter protein; Region: OPT; cl14607
543734006570	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
543734006571	Peptidase family C69; Region: Peptidase_C69; pfam03577
543734006572	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
543734006573	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
543734006574	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
543734006575	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
543734006576	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734006577	Major Facilitator Superfamily; Region: MFS_1; pfam07690
543734006578	putative substrate translocation pore; other site
543734006579	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
543734006580	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
543734006581	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
543734006582	beta-galactosidase; Region: BGL; TIGR03356
543734006583	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
543734006584	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
543734006585	active site turn [active]
543734006586	phosphorylation site [posttranslational modification]
543734006587	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
543734006588	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
543734006589	HPr interaction site; other site
543734006590	glycerol kinase (GK) interaction site [polypeptide binding]; other site
543734006591	active site
543734006592	phosphorylation site [posttranslational modification]
543734006593	transcriptional antiterminator BglG; Provisional; Region: PRK09772
543734006594	CAT RNA binding domain; Region: CAT_RBD; smart01061
543734006595	PRD domain; Region: PRD; pfam00874
543734006596	PRD domain; Region: PRD; pfam00874
543734006597	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
543734006598	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
543734006599	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
543734006600	Walker A/P-loop; other site
543734006601	ATP binding site [chemical binding]; other site
543734006602	Q-loop/lid; other site
543734006603	ABC transporter signature motif; other site
543734006604	Walker B; other site
543734006605	D-loop; other site
543734006606	H-loop/switch region; other site
543734006607	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
543734006608	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
543734006609	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734006610	Walker A/P-loop; other site
543734006611	ATP binding site [chemical binding]; other site
543734006612	Q-loop/lid; other site
543734006613	ABC transporter signature motif; other site
543734006614	Walker B; other site
543734006615	D-loop; other site
543734006616	H-loop/switch region; other site
543734006617	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
543734006618	trimer interface [polypeptide binding]; other site
543734006619	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
543734006620	Transposase; Region: HTH_Tnp_1; pfam01527
543734006621	putative transposase OrfB; Reviewed; Region: PHA02517
543734006622	HTH-like domain; Region: HTH_21; pfam13276
543734006623	Integrase core domain; Region: rve; pfam00665
543734006624	Integrase core domain; Region: rve_3; pfam13683
543734006625	CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd12218
543734006626	CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866
543734006627	tetramer interface [polypeptide binding]; other site
543734006628	putative DNA binding site [nucleotide binding]; other site
543734006629	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442
543734006630	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
543734006631	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
543734006632	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
543734006633	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
543734006634	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
543734006635	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
543734006636	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
543734006637	Walker A/P-loop; other site
543734006638	ATP binding site [chemical binding]; other site
543734006639	Q-loop/lid; other site
543734006640	ABC transporter signature motif; other site
543734006641	Walker B; other site
543734006642	D-loop; other site
543734006643	H-loop/switch region; other site
543734006644	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
543734006645	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
543734006646	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734006647	Walker A/P-loop; other site
543734006648	ATP binding site [chemical binding]; other site
543734006649	Q-loop/lid; other site
543734006650	ABC transporter signature motif; other site
543734006651	Walker B; other site
543734006652	D-loop; other site
543734006653	H-loop/switch region; other site
543734006654	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
543734006655	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
543734006656	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
543734006657	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
543734006658	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
543734006659	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
543734006660	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
543734006661	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
543734006662	adenosine deaminase; Provisional; Region: PRK09358
543734006663	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
543734006664	active site
543734006665	Protein of unknown function (DUF460); Region: DUF460; pfam04312
543734006666	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
543734006667	EamA-like transporter family; Region: EamA; pfam00892
543734006668	EamA-like transporter family; Region: EamA; pfam00892
543734006669	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
543734006670	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
543734006671	Ligand Binding Site [chemical binding]; other site
543734006672	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
543734006673	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734006674	non-specific DNA binding site [nucleotide binding]; other site
543734006675	salt bridge; other site
543734006676	sequence-specific DNA binding site [nucleotide binding]; other site
543734006677	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
543734006678	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
543734006679	epoxyqueuosine reductase; Region: TIGR00276
543734006680	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
543734006681	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
543734006682	protein binding surface [polypeptide binding]; other site
543734006683	HEAT repeats; Region: HEAT_2; pfam13646
543734006684	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
543734006685	Helix-turn-helix domain; Region: HTH_38; pfam13936
543734006686	Integrase core domain; Region: rve; pfam00665
543734006687	BioY family; Region: BioY; pfam02632
543734006688	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
543734006689	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
543734006690	DNA binding residues [nucleotide binding]
543734006691	putative dimer interface [polypeptide binding]; other site
543734006692	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
543734006693	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
543734006694	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
543734006695	catalytic Zn binding site [ion binding]; other site
543734006696	NAD(P) binding site [chemical binding]; other site
543734006697	structural Zn binding site [ion binding]; other site
543734006698	atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267
543734006699	NADH(P)-binding; Region: NAD_binding_10; pfam13460
543734006700	putative NAD(P) binding site [chemical binding]; other site
543734006701	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
543734006702	S-adenosylmethionine binding site [chemical binding]; other site
543734006703	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
543734006704	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
543734006705	catalytic triad [active]
543734006706	Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021
543734006707	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
543734006708	Domain of unknown function DUF21; Region: DUF21; pfam01595
543734006709	FOG: CBS domain [General function prediction only]; Region: COG0517
543734006710	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
543734006711	Transporter associated domain; Region: CorC_HlyC; smart01091
543734006712	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734006713	Major Facilitator Superfamily; Region: MFS_1; pfam07690
543734006714	Maf-like protein; Region: Maf; pfam02545
543734006715	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
543734006716	active site
543734006717	dimer interface [polypeptide binding]; other site
543734006718	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
543734006719	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
543734006720	ATP binding site [chemical binding]; other site
543734006721	Mg2+ binding site [ion binding]; other site
543734006722	G-X-G motif; other site
543734006723	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
543734006724	ATP binding site [chemical binding]; other site
543734006725	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
543734006726	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
543734006727	MutS domain I; Region: MutS_I; pfam01624
543734006728	MutS domain II; Region: MutS_II; pfam05188
543734006729	MutS domain III; Region: MutS_III; pfam05192
543734006730	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
543734006731	Walker A/P-loop; other site
543734006732	ATP binding site [chemical binding]; other site
543734006733	Q-loop/lid; other site
543734006734	ABC transporter signature motif; other site
543734006735	Walker B; other site
543734006736	D-loop; other site
543734006737	H-loop/switch region; other site
543734006738	Amino acid permease; Region: AA_permease_2; pfam13520
543734006739	Domain of unknown function (DUF1827); Region: DUF1827; pfam08860
543734006740	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
543734006741	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
543734006742	ring oligomerisation interface [polypeptide binding]; other site
543734006743	ATP/Mg binding site [chemical binding]; other site
543734006744	stacking interactions; other site
543734006745	hinge regions; other site
543734006746	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
543734006747	oligomerisation interface [polypeptide binding]; other site
543734006748	mobile loop; other site
543734006749	roof hairpin; other site
543734006750	CAAX protease self-immunity; Region: Abi; pfam02517
543734006751	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
543734006752	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
543734006753	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
543734006754	Walker A/P-loop; other site
543734006755	ATP binding site [chemical binding]; other site
543734006756	Q-loop/lid; other site
543734006757	ABC transporter signature motif; other site
543734006758	Walker B; other site
543734006759	D-loop; other site
543734006760	H-loop/switch region; other site
543734006761	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
543734006762	DNA-binding site [nucleotide binding]; DNA binding site
543734006763	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
543734006764	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
543734006765	CoA binding domain; Region: CoA_binding; pfam02629
543734006766	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
543734006767	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734006768	Walker A/P-loop; other site
543734006769	ATP binding site [chemical binding]; other site
543734006770	Q-loop/lid; other site
543734006771	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
543734006772	ABC transporter signature motif; other site
543734006773	Walker B; other site
543734006774	D-loop; other site
543734006775	ABC transporter; Region: ABC_tran_2; pfam12848
543734006776	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
543734006777	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
543734006778	active site
543734006779	P-loop; other site
543734006780	phosphorylation site [posttranslational modification]
543734006781	UGMP family protein; Validated; Region: PRK09604
543734006782	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
543734006783	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
543734006784	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
543734006785	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
543734006786	Coenzyme A binding pocket [chemical binding]; other site
543734006787	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
543734006788	Glycoprotease family; Region: Peptidase_M22; pfam00814
543734006789	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
543734006790	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
543734006791	active site
543734006792	homotetramer interface [polypeptide binding]; other site
543734006793	homodimer interface [polypeptide binding]; other site
543734006794	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
543734006795	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
543734006796	active site
543734006797	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
543734006798	active site 2 [active]
543734006799	active site 1 [active]
543734006800	Predicted methyltransferases [General function prediction only]; Region: COG0313
543734006801	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
543734006802	putative SAM binding site [chemical binding]; other site
543734006803	putative homodimer interface [polypeptide binding]; other site
543734006804	Protein of unknown function (DUF972); Region: DUF972; pfam06156
543734006805	DNA polymerase III subunit delta'; Validated; Region: PRK08058
543734006806	DNA polymerase III subunit delta'; Validated; Region: PRK08485
543734006807	Protein of unknown function (DUF970); Region: DUF970; pfam06153
543734006808	thymidylate kinase; Validated; Region: tmk; PRK00698
543734006809	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
543734006810	TMP-binding site; other site
543734006811	ATP-binding site [chemical binding]; other site
543734006812	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
543734006813	recombination protein RecR; Reviewed; Region: recR; PRK00076
543734006814	RecR protein; Region: RecR; pfam02132
543734006815	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
543734006816	putative active site [active]
543734006817	putative metal-binding site [ion binding]; other site
543734006818	tetramer interface [polypeptide binding]; other site
543734006819	hypothetical protein; Validated; Region: PRK00153
543734006820	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
543734006821	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
543734006822	Walker A motif; other site
543734006823	ATP binding site [chemical binding]; other site
543734006824	Walker B motif; other site
543734006825	arginine finger; other site
543734006826	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
543734006827	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
543734006828	nucleoside/Zn binding site; other site
543734006829	dimer interface [polypeptide binding]; other site
543734006830	catalytic motif [active]
543734006831	Methyltransferase domain; Region: Methyltransf_31; pfam13847
543734006832	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
543734006833	S-adenosylmethionine binding site [chemical binding]; other site
543734006834	Predicted integral membrane protein [Function unknown]; Region: COG0392
543734006835	Uncharacterized conserved protein [Function unknown]; Region: COG2898
543734006836	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
543734006837	Transcriptional regulators [Transcription]; Region: PurR; COG1609
543734006838	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
543734006839	DNA binding site [nucleotide binding]
543734006840	domain linker motif; other site
543734006841	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
543734006842	putative dimerization interface [polypeptide binding]; other site
543734006843	putative ligand binding site [chemical binding]; other site
543734006844	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
543734006845	putative active site [active]
543734006846	catalytic triad [active]
543734006847	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
543734006848	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
543734006849	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
543734006850	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
543734006851	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
543734006852	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
543734006853	core dimer interface [polypeptide binding]; other site
543734006854	peripheral dimer interface [polypeptide binding]; other site
543734006855	L10 interface [polypeptide binding]; other site
543734006856	L11 interface [polypeptide binding]; other site
543734006857	putative EF-Tu interaction site [polypeptide binding]; other site
543734006858	putative EF-G interaction site [polypeptide binding]; other site
543734006859	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
543734006860	23S rRNA interface [nucleotide binding]; other site
543734006861	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
543734006862	drug efflux system protein MdtG; Provisional; Region: PRK09874
543734006863	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734006864	putative substrate translocation pore; other site
543734006865	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734006866	putative substrate translocation pore; other site
543734006867	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
543734006868	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
543734006869	NAD(P) binding site [chemical binding]; other site
543734006870	catalytic residues [active]
543734006871	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
543734006872	mRNA/rRNA interface [nucleotide binding]; other site
543734006873	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
543734006874	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
543734006875	23S rRNA interface [nucleotide binding]; other site
543734006876	L7/L12 interface [polypeptide binding]; other site
543734006877	putative thiostrepton binding site; other site
543734006878	L25 interface [polypeptide binding]; other site
543734006879	magnesium-transporting ATPase; Provisional; Region: PRK15122
543734006880	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
543734006881	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
543734006882	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
543734006883	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734006884	motif II; other site
543734006885	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
543734006886	amidase; Provisional; Region: PRK06529
543734006887	Amidase; Region: Amidase; cl11426
543734006888	Domain of unknown function (DU1801); Region: DUF1801; cl17490
543734006889	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
543734006890	ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505
543734006891	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
543734006892	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
543734006893	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
543734006894	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
543734006895	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
543734006896	putative homodimer interface [polypeptide binding]; other site
543734006897	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
543734006898	heterodimer interface [polypeptide binding]; other site
543734006899	homodimer interface [polypeptide binding]; other site
543734006900	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
543734006901	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
543734006902	UbiA prenyltransferase family; Region: UbiA; pfam01040
543734006903	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
543734006904	UbiA prenyltransferase family; Region: UbiA; pfam01040
543734006905	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
543734006906	ApbE family; Region: ApbE; pfam02424
543734006907	FMN-binding domain; Region: FMN_bind; cl01081
543734006908	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
543734006909	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
543734006910	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
543734006911	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
543734006912	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
543734006913	trimer interface [polypeptide binding]; other site
543734006914	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456
543734006915	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
543734006916	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
543734006917	substrate binding pocket [chemical binding]; other site
543734006918	chain length determination region; other site
543734006919	substrate-Mg2+ binding site; other site
543734006920	catalytic residues [active]
543734006921	aspartate-rich region 1; other site
543734006922	active site lid residues [active]
543734006923	aspartate-rich region 2; other site
543734006924	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
543734006925	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
543734006926	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
543734006927	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
543734006928	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
543734006929	YacP-like NYN domain; Region: NYN_YacP; pfam05991
543734006930	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
543734006931	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
543734006932	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
543734006933	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
543734006934	active site
543734006935	metal binding site [ion binding]; metal-binding site
543734006936	dimerization interface [polypeptide binding]; other site
543734006937	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
543734006938	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
543734006939	active site
543734006940	HIGH motif; other site
543734006941	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
543734006942	KMSKS motif; other site
543734006943	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
543734006944	tRNA binding surface [nucleotide binding]; other site
543734006945	anticodon binding site; other site
543734006946	FAD binding domain; Region: FAD_binding_4; pfam01565
543734006947	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
543734006948	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
543734006949	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
543734006950	active site
543734006951	HIGH motif; other site
543734006952	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
543734006953	active site
543734006954	KMSKS motif; other site
543734006955	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
543734006956	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
543734006957	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
543734006958	tetramer (dimer of dimers) interface [polypeptide binding]; other site
543734006959	active site
543734006960	dimer interface [polypeptide binding]; other site
543734006961	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
543734006962	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
543734006963	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
543734006964	putative active site [active]
543734006965	Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086
543734006966	Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810
543734006967	Predicted membrane protein [General function prediction only]; Region: COG4194
543734006968	Predicted transcriptional regulators [Transcription]; Region: COG1725
543734006969	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
543734006970	DNA-binding site [nucleotide binding]; DNA binding site
543734006971	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
543734006972	putative DNA binding site [nucleotide binding]; other site
543734006973	dimerization interface [polypeptide binding]; other site
543734006974	putative Zn2+ binding site [ion binding]; other site
543734006975	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
543734006976	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734006977	Walker A/P-loop; other site
543734006978	ATP binding site [chemical binding]; other site
543734006979	Q-loop/lid; other site
543734006980	ABC transporter signature motif; other site
543734006981	Walker B; other site
543734006982	D-loop; other site
543734006983	H-loop/switch region; other site
543734006984	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
543734006985	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
543734006986	ABC-2 type transporter; Region: ABC2_membrane; cl17235
543734006987	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
543734006988	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
543734006989	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
543734006990	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
543734006991	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
543734006992	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
543734006993	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
543734006994	Walker A/P-loop; other site
543734006995	ATP binding site [chemical binding]; other site
543734006996	Q-loop/lid; other site
543734006997	ABC transporter signature motif; other site
543734006998	Walker B; other site
543734006999	D-loop; other site
543734007000	H-loop/switch region; other site
543734007001	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
543734007002	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734007003	non-specific DNA binding site [nucleotide binding]; other site
543734007004	salt bridge; other site
543734007005	sequence-specific DNA binding site [nucleotide binding]; other site
543734007006	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
543734007007	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
543734007008	putative active site [active]
543734007009	DNA repair protein RadA; Provisional; Region: PRK11823
543734007010	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
543734007011	Walker A motif/ATP binding site; other site
543734007012	ATP binding site [chemical binding]; other site
543734007013	Walker B motif; other site
543734007014	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
543734007015	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
543734007016	trimer interface [polypeptide binding]; other site
543734007017	active site
543734007018	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
543734007019	Coenzyme A binding pocket [chemical binding]; other site
543734007020	Protein of unknown function (DUF805); Region: DUF805; pfam05656
543734007021	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
543734007022	trimer interface [polypeptide binding]; other site
543734007023	active site
543734007024	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
543734007025	trimer interface [polypeptide binding]; other site
543734007026	active site
543734007027	G bulge; other site
543734007028	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
543734007029	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734007030	Walker A/P-loop; other site
543734007031	ATP binding site [chemical binding]; other site
543734007032	Q-loop/lid; other site
543734007033	ABC transporter signature motif; other site
543734007034	Walker B; other site
543734007035	D-loop; other site
543734007036	H-loop/switch region; other site
543734007037	K+ potassium transporter; Region: K_trans; pfam02705
543734007038	pyruvate phosphate dikinase; Provisional; Region: PRK09279
543734007039	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
543734007040	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
543734007041	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
543734007042	HTH domain; Region: HTH_11; pfam08279
543734007043	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
543734007044	FOG: CBS domain [General function prediction only]; Region: COG0517
543734007045	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
543734007046	catalytic core [active]
543734007047	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
543734007048	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
543734007049	L-lactate oxidase; Region: L_lactate_ox; TIGR02708
543734007050	L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2.  This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737
543734007051	teramer interface [polypeptide binding]; other site
543734007052	active site
543734007053	FMN binding site [chemical binding]; other site
543734007054	catalytic residues [active]
543734007055	CsbD-like; Region: CsbD; pfam05532
543734007056	phosphopentomutase; Provisional; Region: PRK05362
543734007057	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
543734007058	benzoate transport; Region: 2A0115; TIGR00895
543734007059	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734007060	putative substrate translocation pore; other site
543734007061	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
543734007062	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
543734007063	benzoate transport; Region: 2A0115; TIGR00895
543734007064	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734007065	putative substrate translocation pore; other site
543734007066	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
543734007067	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
543734007068	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734007069	H+ Antiporter protein; Region: 2A0121; TIGR00900
543734007070	putative substrate translocation pore; other site
543734007071	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
543734007072	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
543734007073	putative catalytic cysteine [active]
543734007074	gamma-glutamyl kinase; Provisional; Region: PRK05429
543734007075	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
543734007076	nucleotide binding site [chemical binding]; other site
543734007077	homotetrameric interface [polypeptide binding]; other site
543734007078	putative phosphate binding site [ion binding]; other site
543734007079	putative allosteric binding site; other site
543734007080	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
543734007081	active site
543734007082	catalytic site [active]
543734007083	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
543734007084	Cna protein B-type domain; Region: Cna_B; pfam05738
543734007085	Cna protein B-type domain; Region: Cna_B; pfam05738
543734007086	Cna protein B-type domain; Region: Cna_B; pfam05738
543734007087	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
543734007088	Uncharacterized conserved protein [Function unknown]; Region: COG3410
543734007089	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
543734007090	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
543734007091	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734007092	non-specific DNA binding site [nucleotide binding]; other site
543734007093	salt bridge; other site
543734007094	sequence-specific DNA binding site [nucleotide binding]; other site
543734007095	Predicted transcriptional regulators [Transcription]; Region: COG1695
543734007096	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
543734007097	Enterocin A Immunity; Region: EntA_Immun; pfam08951
543734007098	Enterocin A Immunity; Region: EntA_Immun; pfam08951
543734007099	Enterocin A Immunity; Region: EntA_Immun; pfam08951
543734007100	Uncharacterized conserved protein [Function unknown]; Region: COG2966
543734007101	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
543734007102	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
543734007103	hypothetical protein
543734007104	bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000
543734007105	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
543734007106	HlyD family secretion protein; Region: HlyD_3; pfam13437
543734007107	ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193
543734007108	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
543734007109	putative active site [active]
543734007110	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
543734007111	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734007112	Walker A/P-loop; other site
543734007113	ATP binding site [chemical binding]; other site
543734007114	Q-loop/lid; other site
543734007115	ABC transporter signature motif; other site
543734007116	Walker B; other site
543734007117	D-loop; other site
543734007118	H-loop/switch region; other site
543734007119	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
543734007120	putative active site [active]
543734007121	sensory histidine kinase DcuS; Provisional; Region: PRK11086
543734007122	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
543734007123	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
543734007124	active site
543734007125	phosphorylation site [posttranslational modification]
543734007126	intermolecular recognition site; other site
543734007127	dimerization interface [polypeptide binding]; other site
543734007128	LytTr DNA-binding domain; Region: LytTR; pfam04397
543734007129	CAAX protease self-immunity; Region: Abi; pfam02517
543734007130	CAAX protease self-immunity; Region: Abi; pfam02517
543734007131	Enterocin A Immunity; Region: EntA_Immun; pfam08951
543734007132	maltose O-acetyltransferase; Provisional; Region: PRK10092
543734007133	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
543734007134	active site
543734007135	substrate binding site [chemical binding]; other site
543734007136	trimer interface [polypeptide binding]; other site
543734007137	CoA binding site [chemical binding]; other site
543734007138	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
543734007139	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
543734007140	active site
543734007141	catalytic tetrad [active]
543734007142	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
543734007143	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
543734007144	NAD(P) binding site [chemical binding]; other site
543734007145	active site
543734007146	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
543734007147	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
543734007148	putative active site [active]
543734007149	putative FMN binding site [chemical binding]; other site
543734007150	putative substrate binding site [chemical binding]; other site
543734007151	putative catalytic residue [active]
543734007152	fumarate hydratase; Reviewed; Region: fumC; PRK00485
543734007153	Class II fumarases; Region: Fumarase_classII; cd01362
543734007154	active site
543734007155	tetramer interface [polypeptide binding]; other site
543734007156	manganese transport protein MntH; Reviewed; Region: PRK00701
543734007157	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
543734007158	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
543734007159	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
543734007160	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
543734007161	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
543734007162	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734007163	motif II; other site
543734007164	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
543734007165	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734007166	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
543734007167	putative substrate translocation pore; other site
543734007168	multicopper oxidase; Provisional; Region: PRK10965
543734007169	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
543734007170	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
543734007171	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
543734007172	Cation efflux family; Region: Cation_efflux; cl00316
543734007173	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
543734007174	dimerization interface [polypeptide binding]; other site
543734007175	putative DNA binding site [nucleotide binding]; other site
543734007176	putative Zn2+ binding site [ion binding]; other site
543734007177	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
543734007178	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
543734007179	metal binding site [ion binding]; metal-binding site
543734007180	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
543734007181	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
543734007182	ABC-ATPase subunit  interface; other site
543734007183	dimer interface [polypeptide binding]; other site
543734007184	putative PBP binding regions; other site
543734007185	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
543734007186	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
543734007187	Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088
543734007188	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
543734007189	NAD binding site [chemical binding]; other site
543734007190	catalytic residues [active]
543734007191	substrate binding site [chemical binding]; other site
543734007192	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
543734007193	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
543734007194	Helix-turn-helix domain; Region: HTH_38; pfam13936
543734007195	Integrase core domain; Region: rve; pfam00665
543734007196	Metal binding protein TroA_b.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020
543734007197	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
543734007198	metal binding site [ion binding]; metal-binding site
543734007199	atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267
543734007200	NADH(P)-binding; Region: NAD_binding_10; pfam13460
543734007201	putative NAD(P) binding site [chemical binding]; other site
543734007202	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
543734007203	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
543734007204	nudix motif; other site
543734007205	Collagen binding domain; Region: Collagen_bind; pfam05737
543734007206	Cna protein B-type domain; Region: Cna_B; pfam05738
543734007207	Metal binding protein TroA_b.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020
543734007208	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
543734007209	metal binding site [ion binding]; metal-binding site
543734007210	hypothetical protein
543734007211	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
543734007212	SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320
543734007213	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
543734007214	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
543734007215	Walker A motif; other site
543734007216	ATP binding site [chemical binding]; other site
543734007217	Walker B motif; other site
543734007218	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
543734007219	Enolase, N-terminal domain; Region: Enolase_N; pfam03952
543734007220	phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098
543734007221	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
543734007222	membrane-bound complex binding site; other site
543734007223	hinge residues; other site
543734007224	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
543734007225	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
543734007226	Walker A/P-loop; other site
543734007227	ATP binding site [chemical binding]; other site
543734007228	Q-loop/lid; other site
543734007229	ABC transporter signature motif; other site
543734007230	Walker B; other site
543734007231	D-loop; other site
543734007232	H-loop/switch region; other site
543734007233	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
543734007234	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734007235	dimer interface [polypeptide binding]; other site
543734007236	conserved gate region; other site
543734007237	putative PBP binding loops; other site
543734007238	ABC-ATPase subunit interface; other site
543734007239	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
543734007240	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734007241	dimer interface [polypeptide binding]; other site
543734007242	conserved gate region; other site
543734007243	putative PBP binding loops; other site
543734007244	ABC-ATPase subunit interface; other site
543734007245	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
543734007246	Helix-turn-helix domain; Region: HTH_38; pfam13936
543734007247	Integrase core domain; Region: rve; pfam00665
543734007248	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
543734007249	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
543734007250	substrate binding pocket [chemical binding]; other site
543734007251	membrane-bound complex binding site; other site
543734007252	hinge residues; other site
543734007253	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
543734007254	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
543734007255	Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926
543734007256	acyl-activating enzyme (AAE) consensus motif; other site
543734007257	acyl-activating enzyme (AAE) consensus motif; other site
543734007258	putative AMP binding site [chemical binding]; other site
543734007259	putative active site [active]
543734007260	putative CoA binding site [chemical binding]; other site
543734007261	Acyltransferase family; Region: Acyl_transf_3; pfam01757
543734007262	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
543734007263	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734007264	Walker A/P-loop; other site
543734007265	ATP binding site [chemical binding]; other site
543734007266	Q-loop/lid; other site
543734007267	ABC transporter signature motif; other site
543734007268	Walker B; other site
543734007269	D-loop; other site
543734007270	H-loop/switch region; other site
543734007271	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
543734007272	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734007273	putative PBP binding loops; other site
543734007274	dimer interface [polypeptide binding]; other site
543734007275	ABC-ATPase subunit interface; other site
543734007276	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
543734007277	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
543734007278	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
543734007279	ABC transporter; Region: ABC_tran; pfam00005
543734007280	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734007281	Q-loop/lid; other site
543734007282	ABC transporter signature motif; other site
543734007283	Walker B; other site
543734007284	D-loop; other site
543734007285	H-loop/switch region; other site
543734007286	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
543734007287	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
543734007288	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
543734007289	23S rRNA interface [nucleotide binding]; other site
543734007290	L3 interface [polypeptide binding]; other site
543734007291	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
543734007292	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
543734007293	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
543734007294	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
543734007295	Walker A/P-loop; other site
543734007296	ATP binding site [chemical binding]; other site
543734007297	Q-loop/lid; other site
543734007298	ABC transporter signature motif; other site
543734007299	Walker B; other site
543734007300	D-loop; other site
543734007301	H-loop/switch region; other site
543734007302	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
543734007303	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
543734007304	DNA binding residues [nucleotide binding]
543734007305	dimer interface [polypeptide binding]; other site
543734007306	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
543734007307	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
543734007308	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
543734007309	dimerization interface 3.5A [polypeptide binding]; other site
543734007310	active site
543734007311	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
543734007312	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
543734007313	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
543734007314	Walker A/P-loop; other site
543734007315	ATP binding site [chemical binding]; other site
543734007316	Q-loop/lid; other site
543734007317	ABC transporter signature motif; other site
543734007318	Walker B; other site
543734007319	D-loop; other site
543734007320	H-loop/switch region; other site
543734007321	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
543734007322	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
543734007323	Walker A/P-loop; other site
543734007324	ATP binding site [chemical binding]; other site
543734007325	Q-loop/lid; other site
543734007326	ABC transporter signature motif; other site
543734007327	Walker B; other site
543734007328	D-loop; other site
543734007329	H-loop/switch region; other site
543734007330	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
543734007331	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
543734007332	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
543734007333	alphaNTD homodimer interface [polypeptide binding]; other site
543734007334	alphaNTD - beta interaction site [polypeptide binding]; other site
543734007335	alphaNTD - beta' interaction site [polypeptide binding]; other site
543734007336	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
543734007337	30S ribosomal protein S11; Validated; Region: PRK05309
543734007338	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
543734007339	30S ribosomal protein S13; Region: bact_S13; TIGR03631
543734007340	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
543734007341	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
543734007342	rRNA binding site [nucleotide binding]; other site
543734007343	predicted 30S ribosome binding site; other site
543734007344	adenylate kinase; Reviewed; Region: adk; PRK00279
543734007345	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
543734007346	AMP-binding site [chemical binding]; other site
543734007347	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
543734007348	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
543734007349	SecY translocase; Region: SecY; pfam00344
543734007350	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
543734007351	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
543734007352	23S rRNA binding site [nucleotide binding]; other site
543734007353	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
543734007354	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
543734007355	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
543734007356	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
543734007357	5S rRNA interface [nucleotide binding]; other site
543734007358	L27 interface [polypeptide binding]; other site
543734007359	23S rRNA interface [nucleotide binding]; other site
543734007360	L5 interface [polypeptide binding]; other site
543734007361	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
543734007362	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
543734007363	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
543734007364	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
543734007365	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
543734007366	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
543734007367	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
543734007368	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
543734007369	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
543734007370	RNA binding site [nucleotide binding]; other site
543734007371	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
543734007372	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
543734007373	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
543734007374	23S rRNA interface [nucleotide binding]; other site
543734007375	putative translocon interaction site; other site
543734007376	signal recognition particle (SRP54) interaction site; other site
543734007377	L23 interface [polypeptide binding]; other site
543734007378	trigger factor interaction site; other site
543734007379	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
543734007380	23S rRNA interface [nucleotide binding]; other site
543734007381	5S rRNA interface [nucleotide binding]; other site
543734007382	putative antibiotic binding site [chemical binding]; other site
543734007383	L25 interface [polypeptide binding]; other site
543734007384	L27 interface [polypeptide binding]; other site
543734007385	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
543734007386	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
543734007387	G-X-X-G motif; other site
543734007388	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
543734007389	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
543734007390	putative translocon binding site; other site
543734007391	protein-rRNA interface [nucleotide binding]; other site
543734007392	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
543734007393	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
543734007394	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
543734007395	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
543734007396	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
543734007397	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
543734007398	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
543734007399	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
543734007400	phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833
543734007401	peroxiredoxin; Region: AhpC; TIGR03137
543734007402	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
543734007403	dimer interface [polypeptide binding]; other site
543734007404	decamer (pentamer of dimers) interface [polypeptide binding]; other site
543734007405	catalytic triad [active]
543734007406	peroxidatic and resolving cysteines [active]
543734007407	Predicted transcriptional regulator [Transcription]; Region: COG2378
543734007408	WYL domain; Region: WYL; pfam13280
543734007409	elongation factor G; Reviewed; Region: PRK12739
543734007410	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
543734007411	G1 box; other site
543734007412	putative GEF interaction site [polypeptide binding]; other site
543734007413	GTP/Mg2+ binding site [chemical binding]; other site
543734007414	Switch I region; other site
543734007415	G2 box; other site
543734007416	G3 box; other site
543734007417	Switch II region; other site
543734007418	G4 box; other site
543734007419	G5 box; other site
543734007420	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
543734007421	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
543734007422	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
543734007423	30S ribosomal protein S7; Validated; Region: PRK05302
543734007424	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
543734007425	S17 interaction site [polypeptide binding]; other site
543734007426	S8 interaction site; other site
543734007427	16S rRNA interaction site [nucleotide binding]; other site
543734007428	streptomycin interaction site [chemical binding]; other site
543734007429	23S rRNA interaction site [nucleotide binding]; other site
543734007430	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
543734007431	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
543734007432	Cna protein B-type domain; Region: Cna_B; pfam05738
543734007433	Cna protein B-type domain; Region: Cna_B; pfam05738
543734007434	Cna protein B-type domain; Region: Cna_B; pfam05738
543734007435	Cna protein B-type domain; Region: Cna_B; pfam05738
543734007436	Cna protein B-type domain; Region: Cna_B; pfam05738
543734007437	Cna protein B-type domain; Region: Cna_B; pfam05738
543734007438	Cna protein B-type domain; Region: Cna_B; pfam05738
543734007439	Cna protein B-type domain; Region: Cna_B; pfam05738
543734007440	Cna protein B-type domain; Region: Cna_B; pfam05738
543734007441	Cna protein B-type domain; Region: Cna_B; pfam05738
543734007442	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
543734007443	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
543734007444	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
543734007445	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
543734007446	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
543734007447	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
543734007448	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
543734007449	DNA binding site [nucleotide binding]
543734007450	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
543734007451	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
543734007452	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
543734007453	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
543734007454	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
543734007455	RPB1 interaction site [polypeptide binding]; other site
543734007456	RPB10 interaction site [polypeptide binding]; other site
543734007457	RPB11 interaction site [polypeptide binding]; other site
543734007458	RPB3 interaction site [polypeptide binding]; other site
543734007459	RPB12 interaction site [polypeptide binding]; other site
543734007460	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
543734007461	Clp amino terminal domain; Region: Clp_N; pfam02861
543734007462	Clp amino terminal domain; Region: Clp_N; pfam02861
543734007463	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
543734007464	Walker A motif; other site
543734007465	ATP binding site [chemical binding]; other site
543734007466	Walker B motif; other site
543734007467	arginine finger; other site
543734007468	UvrB/uvrC motif; Region: UVR; pfam02151
543734007469	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
543734007470	Walker A motif; other site
543734007471	ATP binding site [chemical binding]; other site
543734007472	Walker B motif; other site
543734007473	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
543734007474	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
543734007475	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
543734007476	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
543734007477	dimer interface [polypeptide binding]; other site
543734007478	putative anticodon binding site; other site
543734007479	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
543734007480	motif 1; other site
543734007481	active site
543734007482	motif 2; other site
543734007483	motif 3; other site
543734007484	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
543734007485	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
543734007486	FMN binding site [chemical binding]; other site
543734007487	active site
543734007488	catalytic residues [active]
543734007489	substrate binding site [chemical binding]; other site
543734007490	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
543734007491	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
543734007492	dimerization interface [polypeptide binding]; other site
543734007493	domain crossover interface; other site
543734007494	redox-dependent activation switch; other site
543734007495	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
543734007496	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
543734007497	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
543734007498	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
543734007499	legume lectins; Region: lectin_L-type; cl14058
543734007500	homotetramer interaction site [polypeptide binding]; other site
543734007501	homodimer interaction site [polypeptide binding]; other site
543734007502	carbohydrate binding site [chemical binding]; other site
543734007503	metal binding site [ion binding]; metal-binding site
543734007504	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
543734007505	WxL domain surface cell wall-binding; Region: WxL; pfam13731
543734007506	FtsH Extracellular; Region: FtsH_ext; pfam06480
543734007507	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
543734007508	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
543734007509	Walker A motif; other site
543734007510	ATP binding site [chemical binding]; other site
543734007511	Walker B motif; other site
543734007512	arginine finger; other site
543734007513	Peptidase family M41; Region: Peptidase_M41; pfam01434
543734007514	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
543734007515	active site
543734007516	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
543734007517	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
543734007518	Ligand Binding Site [chemical binding]; other site
543734007519	TilS substrate C-terminal domain; Region: TilS_C; smart00977
543734007520	hypothetical protein; Provisional; Region: PRK08582
543734007521	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
543734007522	RNA binding site [nucleotide binding]; other site
543734007523	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
543734007524	Septum formation initiator; Region: DivIC; pfam04977
543734007525	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
543734007526	RNA binding surface [nucleotide binding]; other site
543734007527	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
543734007528	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
543734007529	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
543734007530	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
543734007531	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
543734007532	ATP binding site [chemical binding]; other site
543734007533	putative Mg++ binding site [ion binding]; other site
543734007534	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
543734007535	nucleotide binding region [chemical binding]; other site
543734007536	ATP-binding site [chemical binding]; other site
543734007537	TRCF domain; Region: TRCF; pfam03461
543734007538	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
543734007539	putative active site [active]
543734007540	catalytic residue [active]
543734007541	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
543734007542	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
543734007543	tetramer (dimer of dimers) interface [polypeptide binding]; other site
543734007544	NAD binding site [chemical binding]; other site
543734007545	dimer interface [polypeptide binding]; other site
543734007546	substrate binding site [chemical binding]; other site
543734007547	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
543734007548	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
543734007549	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
543734007550	Predicted transcriptional regulators [Transcription]; Region: COG1695
543734007551	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
543734007552	Predicted membrane protein [Function unknown]; Region: COG1511
543734007553	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
543734007554	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
543734007555	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
543734007556	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
543734007557	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
543734007558	FOG: CBS domain [General function prediction only]; Region: COG0517
543734007559	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
543734007560	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
543734007561	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
543734007562	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
543734007563	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
543734007564	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
543734007565	active site
543734007566	dimer interface [polypeptide binding]; other site
543734007567	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
543734007568	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
543734007569	active site
543734007570	FMN binding site [chemical binding]; other site
543734007571	substrate binding site [chemical binding]; other site
543734007572	3Fe-4S cluster binding site [ion binding]; other site
543734007573	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
543734007574	domain interface; other site
543734007575	QueT transporter; Region: QueT; pfam06177
543734007576	PemK-like protein; Region: PemK; pfam02452
543734007577	hypothetical protein; Region: PHA01623
543734007578	alanine racemase; Reviewed; Region: alr; PRK00053
543734007579	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
543734007580	active site
543734007581	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
543734007582	dimer interface [polypeptide binding]; other site
543734007583	substrate binding site [chemical binding]; other site
543734007584	catalytic residues [active]
543734007585	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
543734007586	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
543734007587	DEAD-like helicases superfamily; Region: DEXDc; smart00487
543734007588	ATP binding site [chemical binding]; other site
543734007589	Mg++ binding site [ion binding]; other site
543734007590	motif III; other site
543734007591	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
543734007592	nucleotide binding region [chemical binding]; other site
543734007593	ATP-binding site [chemical binding]; other site
543734007594	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
543734007595	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
543734007596	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
543734007597	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
543734007598	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
543734007599	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
543734007600	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
543734007601	hinge; other site
543734007602	active site
543734007603	CTP synthetase; Validated; Region: pyrG; PRK05380
543734007604	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
543734007605	Catalytic site [active]
543734007606	active site
543734007607	UTP binding site [chemical binding]; other site
543734007608	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
543734007609	active site
543734007610	putative oxyanion hole; other site
543734007611	catalytic triad [active]
543734007612	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
543734007613	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
543734007614	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
543734007615	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
543734007616	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
543734007617	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
543734007618	Zn2+ binding site [ion binding]; other site
543734007619	Mg2+ binding site [ion binding]; other site
543734007620	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
543734007621	putative active site [active]
543734007622	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
543734007623	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
543734007624	ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555
543734007625	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
543734007626	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
543734007627	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
543734007628	active site
543734007629	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
543734007630	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
543734007631	Substrate binding site; other site
543734007632	Mg++ binding site; other site
543734007633	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
543734007634	active site
543734007635	substrate binding site [chemical binding]; other site
543734007636	CoA binding site [chemical binding]; other site
543734007637	VanZ like family; Region: VanZ; pfam04892
543734007638	RDD family; Region: RDD; pfam06271
543734007639	pur operon repressor; Provisional; Region: PRK09213
543734007640	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
543734007641	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
543734007642	active site
543734007643	putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247
543734007644	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
543734007645	Walker A/P-loop; other site
543734007646	ATP binding site [chemical binding]; other site
543734007647	Q-loop/lid; other site
543734007648	ABC transporter signature motif; other site
543734007649	Walker B; other site
543734007650	D-loop; other site
543734007651	H-loop/switch region; other site
543734007652	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
543734007653	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
543734007654	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
543734007655	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
543734007656	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
543734007657	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
543734007658	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
543734007659	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
543734007660	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
543734007661	S-adenosylmethionine binding site [chemical binding]; other site
543734007662	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
543734007663	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
543734007664	putative active site [active]
543734007665	putative metal binding site [ion binding]; other site
543734007666	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
543734007667	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
543734007668	active site
543734007669	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
543734007670	active site
543734007671	phosphorylation site [posttranslational modification]
543734007672	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
543734007673	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
543734007674	active site
543734007675	catalytic residues [active]
543734007676	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
543734007677	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
543734007678	active site
543734007679	phosphorylation site [posttranslational modification]
543734007680	intermolecular recognition site; other site
543734007681	dimerization interface [polypeptide binding]; other site
543734007682	LytTr DNA-binding domain; Region: LytTR; smart00850
543734007683	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
543734007684	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
543734007685	ATP binding site [chemical binding]; other site
543734007686	Mg2+ binding site [ion binding]; other site
543734007687	G-X-G motif; other site
543734007688	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
543734007689	Transmembrane protein 231; Region: TM231; pfam10149
543734007690	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734007691	Walker A/P-loop; other site
543734007692	ATP binding site [chemical binding]; other site
543734007693	Q-loop/lid; other site
543734007694	ABC transporter signature motif; other site
543734007695	Walker B; other site
543734007696	D-loop; other site
543734007697	H-loop/switch region; other site
543734007698	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
543734007699	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734007700	Walker A/P-loop; other site
543734007701	ATP binding site [chemical binding]; other site
543734007702	Q-loop/lid; other site
543734007703	ABC transporter signature motif; other site
543734007704	Walker B; other site
543734007705	D-loop; other site
543734007706	H-loop/switch region; other site
543734007707	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
543734007708	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
543734007709	active site
543734007710	HIGH motif; other site
543734007711	KMSKS motif; other site
543734007712	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
543734007713	tRNA binding surface [nucleotide binding]; other site
543734007714	anticodon binding site; other site
543734007715	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
543734007716	dimer interface [polypeptide binding]; other site
543734007717	putative tRNA-binding site [nucleotide binding]; other site
543734007718	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
543734007719	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
543734007720	Protein of unknown function DUF72; Region: DUF72; pfam01904
543734007721	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
543734007722	putative active site [active]
543734007723	nucleotide binding site [chemical binding]; other site
543734007724	nudix motif; other site
543734007725	putative metal binding site [ion binding]; other site
543734007726	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
543734007727	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
543734007728	LDH/MDH dimer interface [polypeptide binding]; other site
543734007729	NAD(P) binding site [chemical binding]; other site
543734007730	substrate binding site [chemical binding]; other site
543734007731	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
543734007732	NAD-dependent deacetylase; Provisional; Region: PRK00481
543734007733	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
543734007734	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
543734007735	substrate binding site [chemical binding]; other site
543734007736	Predicted secreted protein [Function unknown]; Region: COG4086
543734007737	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
543734007738	exopolyphosphatase; Region: exo_poly_only; TIGR03706
543734007739	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
543734007740	polyphosphate kinase; Provisional; Region: PRK05443
543734007741	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
543734007742	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
543734007743	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
543734007744	putative domain interface [polypeptide binding]; other site
543734007745	putative active site [active]
543734007746	catalytic site [active]
543734007747	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
543734007748	putative domain interface [polypeptide binding]; other site
543734007749	putative active site [active]
543734007750	catalytic site [active]
543734007751	exopolyphosphatase; Region: exo_poly_only; TIGR03706
543734007752	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
543734007753	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
543734007754	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
543734007755	active site
543734007756	catalytic tetrad [active]
543734007757	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
543734007758	Methyltransferase domain; Region: Methyltransf_23; pfam13489
543734007759	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
543734007760	S-adenosylmethionine binding site [chemical binding]; other site
543734007761	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
543734007762	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
543734007763	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
543734007764	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
543734007765	Repair protein; Region: Repair_PSII; pfam04536
543734007766	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
543734007767	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
543734007768	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
543734007769	active site
543734007770	HIGH motif; other site
543734007771	dimer interface [polypeptide binding]; other site
543734007772	KMSKS motif; other site
543734007773	FtsX-like permease family; Region: FtsX; pfam02687
543734007774	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
543734007775	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
543734007776	Walker A/P-loop; other site
543734007777	ATP binding site [chemical binding]; other site
543734007778	Q-loop/lid; other site
543734007779	ABC transporter signature motif; other site
543734007780	Walker B; other site
543734007781	D-loop; other site
543734007782	H-loop/switch region; other site
543734007783	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
543734007784	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
543734007785	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
543734007786	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
543734007787	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734007788	Walker A/P-loop; other site
543734007789	ATP binding site [chemical binding]; other site
543734007790	Q-loop/lid; other site
543734007791	ABC transporter signature motif; other site
543734007792	Walker B; other site
543734007793	D-loop; other site
543734007794	H-loop/switch region; other site
543734007795	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734007796	conserved gate region; other site
543734007797	ABC-ATPase subunit interface; other site
543734007798	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
543734007799	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
543734007800	Part of AAA domain; Region: AAA_19; pfam13245
543734007801	Family description; Region: UvrD_C_2; pfam13538
543734007802	Transcriptional regulator [Transcription]; Region: LysR; COG0583
543734007803	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
543734007804	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
543734007805	dimerization interface [polypeptide binding]; other site
543734007806	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
543734007807	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
543734007808	gating phenylalanine in ion channel; other site
543734007809	CAAX protease self-immunity; Region: Abi; pfam02517
543734007810	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
543734007811	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
543734007812	Zn2+ binding site [ion binding]; other site
543734007813	Mg2+ binding site [ion binding]; other site
543734007814	Transcriptional regulators [Transcription]; Region: MarR; COG1846
543734007815	MarR family; Region: MarR; pfam01047
543734007816	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734007817	Walker A/P-loop; other site
543734007818	ATP binding site [chemical binding]; other site
543734007819	Q-loop/lid; other site
543734007820	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
543734007821	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
543734007822	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734007823	ABC transporter signature motif; other site
543734007824	Walker B; other site
543734007825	D-loop; other site
543734007826	H-loop/switch region; other site
543734007827	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734007828	Walker A/P-loop; other site
543734007829	ATP binding site [chemical binding]; other site
543734007830	Q-loop/lid; other site
543734007831	ABC transporter signature motif; other site
543734007832	Walker B; other site
543734007833	D-loop; other site
543734007834	H-loop/switch region; other site
543734007835	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
543734007836	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
543734007837	active site
543734007838	catalytic tetrad [active]
543734007839	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
543734007840	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734007841	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
543734007842	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
543734007843	catalytic core [active]
543734007844	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
543734007845	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734007846	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
543734007847	active site
543734007848	motif I; other site
543734007849	motif II; other site
543734007850	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
543734007851	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
543734007852	RNA/DNA hybrid binding site [nucleotide binding]; other site
543734007853	active site
543734007854	Transcriptional regulator [Transcription]; Region: LysR; COG0583
543734007855	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
543734007856	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
543734007857	dimerization interface [polypeptide binding]; other site
543734007858	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
543734007859	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
543734007860	pyridoxal 5'-phosphate binding site [chemical binding]; other site
543734007861	homodimer interface [polypeptide binding]; other site
543734007862	catalytic residue [active]
543734007863	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734007864	Major Facilitator Superfamily; Region: MFS_1; pfam07690
543734007865	putative substrate translocation pore; other site
543734007866	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734007867	putative substrate translocation pore; other site
543734007868	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
543734007869	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
543734007870	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
543734007871	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
543734007872	RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468
543734007873	hexamer interface [polypeptide binding]; other site
543734007874	Walker A motif; other site
543734007875	ATP binding site [chemical binding]; other site
543734007876	Walker B motif; other site
543734007877	Protein of unknown function (DUF554); Region: DUF554; pfam04474
543734007878	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
543734007879	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
543734007880	active site
543734007881	P-loop; other site
543734007882	phosphorylation site [posttranslational modification]
543734007883	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
543734007884	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
543734007885	active site
543734007886	phosphorylation site [posttranslational modification]
543734007887	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
543734007888	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
543734007889	putative substrate binding site [chemical binding]; other site
543734007890	putative ATP binding site [chemical binding]; other site
543734007891	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
543734007892	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
543734007893	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
543734007894	putative active site [active]
543734007895	glycerol kinase; Provisional; Region: glpK; PRK00047
543734007896	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
543734007897	N- and C-terminal domain interface [polypeptide binding]; other site
543734007898	active site
543734007899	MgATP binding site [chemical binding]; other site
543734007900	catalytic site [active]
543734007901	metal binding site [ion binding]; metal-binding site
543734007902	glycerol binding site [chemical binding]; other site
543734007903	homotetramer interface [polypeptide binding]; other site
543734007904	homodimer interface [polypeptide binding]; other site
543734007905	FBP binding site [chemical binding]; other site
543734007906	protein IIAGlc interface [polypeptide binding]; other site
543734007907	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
543734007908	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
543734007909	DNA-binding site [nucleotide binding]; DNA binding site
543734007910	UTRA domain; Region: UTRA; cl17743
543734007911	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
543734007912	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
543734007913	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
543734007914	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
543734007915	active pocket/dimerization site; other site
543734007916	active site
543734007917	phosphorylation site [posttranslational modification]
543734007918	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
543734007919	active site
543734007920	phosphorylation site [posttranslational modification]
543734007921	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
543734007922	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
543734007923	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
543734007924	active site
543734007925	methionine cluster; other site
543734007926	phosphorylation site [posttranslational modification]
543734007927	metal binding site [ion binding]; metal-binding site
543734007928	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
543734007929	active site
543734007930	P-loop; other site
543734007931	phosphorylation site [posttranslational modification]
543734007932	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
543734007933	beta-galactosidase; Region: BGL; TIGR03356
543734007934	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
543734007935	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
543734007936	nucleotide binding site [chemical binding]; other site
543734007937	Uncharacterized conserved protein [Function unknown]; Region: COG3538
543734007938	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
543734007939	alpha-mannosidase; Provisional; Region: PRK09819
543734007940	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
543734007941	active site
543734007942	metal binding site [ion binding]; metal-binding site
543734007943	catalytic site [active]
543734007944	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
543734007945	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
543734007946	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
543734007947	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
543734007948	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
543734007949	DNA-binding site [nucleotide binding]; DNA binding site
543734007950	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
543734007951	hypothetical protein; Provisional; Region: PRK06357
543734007952	intersubunit interface [polypeptide binding]; other site
543734007953	active site
543734007954	Zn2+ binding site [ion binding]; other site
543734007955	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
543734007956	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
543734007957	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
543734007958	active site
543734007959	P-loop; other site
543734007960	phosphorylation site [posttranslational modification]
543734007961	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
543734007962	active site
543734007963	phosphorylation site [posttranslational modification]
543734007964	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
543734007965	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
543734007966	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
543734007967	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
543734007968	S-adenosylmethionine binding site [chemical binding]; other site
543734007969	Methyltransferase domain; Region: Methyltransf_31; pfam13847
543734007970	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
543734007971	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
543734007972	Ca binding site [ion binding]; other site
543734007973	active site
543734007974	catalytic site [active]
543734007975	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
543734007976	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
543734007977	Preprotein translocase subunit; Region: YajC; pfam02699
543734007978	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
543734007979	active pocket/dimerization site; other site
543734007980	active site
543734007981	phosphorylation site [posttranslational modification]
543734007982	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
543734007983	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
543734007984	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
543734007985	active site
543734007986	phosphorylation site [posttranslational modification]
543734007987	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
543734007988	Transcriptional regulator [Transcription]; Region: IclR; COG1414
543734007989	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
543734007990	Bacterial transcriptional regulator; Region: IclR; pfam01614
543734007991	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
543734007992	2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935
543734007993	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
543734007994	NADP binding site [chemical binding]; other site
543734007995	homodimer interface [polypeptide binding]; other site
543734007996	active site
543734007997	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
543734007998	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
543734007999	active site
543734008000	intersubunit interface [polypeptide binding]; other site
543734008001	catalytic residue [active]
543734008002	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
543734008003	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
543734008004	substrate binding site [chemical binding]; other site
543734008005	ATP binding site [chemical binding]; other site
543734008006	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
543734008007	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
543734008008	active site
543734008009	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
543734008010	tetramer (dimer of dimers) interface [polypeptide binding]; other site
543734008011	active site
543734008012	dimer interface [polypeptide binding]; other site
543734008013	conserved hypothetical integral membrane protein; Region: TIGR03766
543734008014	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
543734008015	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
543734008016	Ligand binding site; other site
543734008017	Putative Catalytic site; other site
543734008018	DXD motif; other site
543734008019	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
543734008020	active site
543734008021	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
543734008022	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
543734008023	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
543734008024	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
543734008025	HAMP domain; Region: HAMP; pfam00672
543734008026	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
543734008027	dimer interface [polypeptide binding]; other site
543734008028	phosphorylation site [posttranslational modification]
543734008029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
543734008030	ATP binding site [chemical binding]; other site
543734008031	Mg2+ binding site [ion binding]; other site
543734008032	G-X-G motif; other site
543734008033	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
543734008034	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
543734008035	active site
543734008036	phosphorylation site [posttranslational modification]
543734008037	intermolecular recognition site; other site
543734008038	dimerization interface [polypeptide binding]; other site
543734008039	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
543734008040	DNA binding site [nucleotide binding]
543734008041	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
543734008042	Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298
543734008043	NAD binding site [chemical binding]; other site
543734008044	sugar binding site [chemical binding]; other site
543734008045	divalent metal binding site [ion binding]; other site
543734008046	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
543734008047	dimer interface [polypeptide binding]; other site
543734008048	bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110
543734008049	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
543734008050	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
543734008051	active site turn [active]
543734008052	phosphorylation site [posttranslational modification]
543734008053	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
543734008054	substrate binding site [chemical binding]; other site
543734008055	catalytic residues [active]
543734008056	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
543734008057	Helix-turn-helix domain; Region: HTH_38; pfam13936
543734008058	Integrase core domain; Region: rve; pfam00665
543734008059	hypothetical protein
543734008060	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
543734008061	Mga helix-turn-helix domain; Region: Mga; pfam05043
543734008062	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
543734008063	Homeodomain-like domain; Region: HTH_23; cl17451
543734008064	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
543734008065	Transposase; Region: HTH_Tnp_1; cl17663
543734008066	Helix-turn-helix domain; Region: HTH_28; pfam13518
543734008067	putative transposase OrfB; Reviewed; Region: PHA02517
543734008068	HTH-like domain; Region: HTH_21; pfam13276
543734008069	Integrase core domain; Region: rve; pfam00665
543734008070	Integrase core domain; Region: rve_3; pfam13683
543734008071	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
543734008072	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
543734008073	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
543734008074	putative active site [active]
543734008075	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
543734008076	HPr interaction site; other site
543734008077	glycerol kinase (GK) interaction site [polypeptide binding]; other site
543734008078	active site
543734008079	phosphorylation site [posttranslational modification]
543734008080	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
543734008081	Uncharacterized conserved protein [Function unknown]; Region: COG1434
543734008082	putative active site [active]
543734008083	Protein of unknown function (DUF1341); Region: DUF1341; pfam07071
543734008084	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
543734008085	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
543734008086	dihydroorotase; Provisional; Region: PRK09237
543734008087	active site
543734008088	Domain of unknown function (DUF4310); Region: DUF4310; pfam14187
543734008089	Domain of unknown function (DUF4311); Region: DUF4311; cl11919
543734008090	Domain of unknown function (DUF4312); Region: DUF4312; pfam14189
543734008091	Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272
543734008092	PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582
543734008093	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
543734008094	HTH domain; Region: HTH_11; pfam08279
543734008095	HTH domain; Region: HTH_11; pfam08279
543734008096	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
543734008097	active site
543734008098	P-loop; other site
543734008099	phosphorylation site [posttranslational modification]
543734008100	Class I aldolases; Region: Aldolase_Class_I; cl17187
543734008101	catalytic residue [active]
543734008102	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829
543734008103	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
543734008104	PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825
543734008105	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
543734008106	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608
543734008107	Glucitol operon activator protein (GutM); Region: GutM; pfam06923
543734008108	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
543734008109	HTH domain; Region: HTH_11; pfam08279
543734008110	PRD domain; Region: PRD; pfam00874
543734008111	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
543734008112	active site
543734008113	phosphorylation site [posttranslational modification]
543734008114	sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171
543734008115	classical (c) SDRs; Region: SDR_c; cd05233
543734008116	NAD(P) binding site [chemical binding]; other site
543734008117	active site
543734008118	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
543734008119	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
543734008120	intersubunit interface [polypeptide binding]; other site
543734008121	active site
543734008122	Zn2+ binding site [ion binding]; other site
543734008123	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734008124	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
543734008125	active site
543734008126	motif I; other site
543734008127	motif II; other site
543734008128	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734008129	motif II; other site
543734008130	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
543734008131	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
543734008132	AP (apurinic/apyrimidinic) site pocket; other site
543734008133	DNA interaction; other site
543734008134	Metal-binding active site; metal-binding site
543734008135	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
543734008136	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
543734008137	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
543734008138	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
543734008139	active site
543734008140	dimer interface [polypeptide binding]; other site
543734008141	magnesium binding site [ion binding]; other site
543734008142	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
543734008143	active site
543734008144	P-loop; other site
543734008145	phosphorylation site [posttranslational modification]
543734008146	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
543734008147	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
543734008148	active site
543734008149	phosphorylation site [posttranslational modification]
543734008150	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
543734008151	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
543734008152	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
543734008153	tetramer (dimer of dimers) interface [polypeptide binding]; other site
543734008154	active site
543734008155	dimer interface [polypeptide binding]; other site
543734008156	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
543734008157	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
543734008158	NAD(P) binding site [chemical binding]; other site
543734008159	Class I aldolases; Region: Aldolase_Class_I; cl17187
543734008160	catalytic residue [active]
543734008161	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
543734008162	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
543734008163	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
543734008164	substrate binding site [chemical binding]; other site
543734008165	hexamer interface [polypeptide binding]; other site
543734008166	metal binding site [ion binding]; metal-binding site
543734008167	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
543734008168	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
543734008169	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
543734008170	active site
543734008171	phosphorylation site [posttranslational modification]
543734008172	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
543734008173	active pocket/dimerization site; other site
543734008174	active site
543734008175	phosphorylation site [posttranslational modification]
543734008176	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
543734008177	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
543734008178	NAD(P) binding site [chemical binding]; other site
543734008179	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
543734008180	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
543734008181	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
543734008182	putative phosphoketolase; Provisional; Region: PRK05261
543734008183	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
543734008184	TPP-binding site; other site
543734008185	XFP C-terminal domain; Region: XFP_C; pfam09363
543734008186	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
543734008187	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
543734008188	nucleotide binding site [chemical binding]; other site
543734008189	Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513
543734008190	active site
543734008191	dimer interface [polypeptide binding]; other site
543734008192	catalytic nucleophile [active]
543734008193	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
543734008194	dipeptidase, putative; Region: dipeptidaselike; TIGR01887
543734008195	active site
543734008196	metal binding site [ion binding]; metal-binding site
543734008197	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
543734008198	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
543734008199	DNA-binding site [nucleotide binding]; DNA binding site
543734008200	UTRA domain; Region: UTRA; pfam07702
543734008201	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
543734008202	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
543734008203	pyridoxal 5'-phosphate binding site [chemical binding]; other site
543734008204	homodimer interface [polypeptide binding]; other site
543734008205	catalytic residue [active]
543734008206	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734008207	Major Facilitator Superfamily; Region: MFS_1; pfam07690
543734008208	putative substrate translocation pore; other site
543734008209	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
543734008210	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
543734008211	D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK; cd07803
543734008212	N- and C-terminal domain interface [polypeptide binding]; other site
543734008213	D-xylulose kinase; Region: XylB; TIGR01312
543734008214	active site
543734008215	MgATP binding site [chemical binding]; other site
543734008216	catalytic site [active]
543734008217	metal binding site [ion binding]; metal-binding site
543734008218	xylulose binding site [chemical binding]; other site
543734008219	homodimer interface [polypeptide binding]; other site
543734008220	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
543734008221	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
543734008222	NAD(P) binding site [chemical binding]; other site
543734008223	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
543734008224	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
543734008225	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
543734008226	active site
543734008227	phosphorylation site [posttranslational modification]
543734008228	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
543734008229	active pocket/dimerization site; other site
543734008230	active site
543734008231	phosphorylation site [posttranslational modification]
543734008232	PRD domain; Region: PRD; pfam00874
543734008233	PRD domain; Region: PRD; pfam00874
543734008234	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
543734008235	active site
543734008236	P-loop; other site
543734008237	phosphorylation site [posttranslational modification]
543734008238	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
543734008239	active site
543734008240	phosphorylation site [posttranslational modification]
543734008241	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
543734008242	Helix-turn-helix domain; Region: HTH_38; pfam13936
543734008243	Integrase core domain; Region: rve; pfam00665
543734008244	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
543734008245	intersubunit interface [polypeptide binding]; other site
543734008246	active site
543734008247	zinc binding site [ion binding]; other site
543734008248	Na+ binding site [ion binding]; other site
543734008249	uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774
543734008250	putative N- and C-terminal domain interface [polypeptide binding]; other site
543734008251	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
543734008252	putative active site [active]
543734008253	putative MgATP binding site [chemical binding]; other site
543734008254	catalytic site [active]
543734008255	metal binding site [ion binding]; metal-binding site
543734008256	putative carbohydrate binding site [chemical binding]; other site
543734008257	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
543734008258	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
543734008259	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
543734008260	active site
543734008261	P-loop; other site
543734008262	phosphorylation site [posttranslational modification]
543734008263	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
543734008264	active site
543734008265	phosphorylation site [posttranslational modification]
543734008266	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
543734008267	intersubunit interface [polypeptide binding]; other site
543734008268	active site
543734008269	zinc binding site [ion binding]; other site
543734008270	Na+ binding site [ion binding]; other site
543734008271	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
543734008272	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
543734008273	DNA-binding site [nucleotide binding]; DNA binding site
543734008274	UTRA domain; Region: UTRA; pfam07702
543734008275	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
543734008276	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
543734008277	Coenzyme A binding pocket [chemical binding]; other site
543734008278	Predicted transcriptional regulators [Transcription]; Region: COG1695
543734008279	Transcriptional regulator PadR-like family; Region: PadR; cl17335
543734008280	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734008281	D-galactonate transporter; Region: 2A0114; TIGR00893
543734008282	putative substrate translocation pore; other site
543734008283	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734008284	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
543734008285	Coenzyme A binding pocket [chemical binding]; other site
543734008286	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
543734008287	Isochorismatase family; Region: Isochorismatase; pfam00857
543734008288	catalytic triad [active]
543734008289	conserved cis-peptide bond; other site
543734008290	Protein of unknown function (DUF3923); Region: DUF3923; pfam13061
543734008291	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
543734008292	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734008293	non-specific DNA binding site [nucleotide binding]; other site
543734008294	salt bridge; other site
543734008295	sequence-specific DNA binding site [nucleotide binding]; other site
543734008296	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
543734008297	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
543734008298	active site
543734008299	catalytic site [active]
543734008300	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
543734008301	Low molecular weight phosphatase family; Region: LMWPc; cd00115
543734008302	active site
543734008303	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
543734008304	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
543734008305	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
543734008306	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734008307	dimer interface [polypeptide binding]; other site
543734008308	conserved gate region; other site
543734008309	putative PBP binding loops; other site
543734008310	ABC-ATPase subunit interface; other site
543734008311	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
543734008312	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734008313	dimer interface [polypeptide binding]; other site
543734008314	conserved gate region; other site
543734008315	putative PBP binding loops; other site
543734008316	ABC-ATPase subunit interface; other site
543734008317	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
543734008318	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
543734008319	Walker A/P-loop; other site
543734008320	ATP binding site [chemical binding]; other site
543734008321	Q-loop/lid; other site
543734008322	ABC transporter signature motif; other site
543734008323	Walker B; other site
543734008324	D-loop; other site
543734008325	H-loop/switch region; other site
543734008326	TOBE domain; Region: TOBE_2; pfam08402
543734008327	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
543734008328	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
543734008329	active site
543734008330	Isochorismatase family; Region: Isochorismatase; pfam00857
543734008331	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
543734008332	catalytic triad [active]
543734008333	conserved cis-peptide bond; other site
543734008334	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
543734008335	nudix motif; other site
543734008336	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
543734008337	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
543734008338	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
543734008339	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
543734008340	active site
543734008341	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
543734008342	Beta-lactamase; Region: Beta-lactamase; pfam00144
543734008343	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
543734008344	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
543734008345	putative active site [active]
543734008346	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
543734008347	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
543734008348	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
543734008349	putative active site [active]
543734008350	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
543734008351	active site
543734008352	phosphorylation site [posttranslational modification]
543734008353	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
543734008354	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
543734008355	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
543734008356	putative phosphate binding site [ion binding]; other site
543734008357	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
543734008358	DHH family; Region: DHH; pfam01368
543734008359	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
543734008360	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
543734008361	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
543734008362	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
543734008363	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
543734008364	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
543734008365	Coenzyme A binding pocket [chemical binding]; other site
543734008366	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
543734008367	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
543734008368	Coenzyme A binding pocket [chemical binding]; other site
543734008369	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
543734008370	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734008371	active site
543734008372	motif I; other site
543734008373	motif II; other site
543734008374	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
543734008375	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
543734008376	putative NAD(P) binding site [chemical binding]; other site
543734008377	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
543734008378	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
543734008379	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
543734008380	hypothetical protein
543734008381	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
543734008382	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
543734008383	Coenzyme A binding pocket [chemical binding]; other site
543734008384	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
543734008385	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
543734008386	Coenzyme A binding pocket [chemical binding]; other site
543734008387	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
543734008388	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
543734008389	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
543734008390	Coenzyme A binding pocket [chemical binding]; other site
543734008391	Divergent AAA domain; Region: AAA_4; pfam04326
543734008392	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
543734008393	Integrase core domain; Region: rve; pfam00665
543734008394	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
543734008395	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
543734008396	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
543734008397	transmembrane helices; other site
543734008398	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681
543734008399	hypothetical protein; Provisional; Region: PRK06446
543734008400	metal binding site [ion binding]; metal-binding site
543734008401	dimer interface [polypeptide binding]; other site
543734008402	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
543734008403	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
543734008404	peptide binding site [polypeptide binding]; other site
543734008405	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
543734008406	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
543734008407	Soluble P-type ATPase [General function prediction only]; Region: COG4087
543734008408	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
543734008409	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
543734008410	putative dimer interface [polypeptide binding]; other site
543734008411	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
543734008412	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
543734008413	protein binding site [polypeptide binding]; other site
543734008414	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
543734008415	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
543734008416	YycH protein; Region: YycI; pfam09648
543734008417	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
543734008418	YycH protein; Region: YycH; pfam07435
543734008419	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
543734008420	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
543734008421	dimerization interface [polypeptide binding]; other site
543734008422	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
543734008423	putative active site [active]
543734008424	heme pocket [chemical binding]; other site
543734008425	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
543734008426	dimer interface [polypeptide binding]; other site
543734008427	phosphorylation site [posttranslational modification]
543734008428	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
543734008429	ATP binding site [chemical binding]; other site
543734008430	Mg2+ binding site [ion binding]; other site
543734008431	G-X-G motif; other site
543734008432	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
543734008433	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
543734008434	active site
543734008435	phosphorylation site [posttranslational modification]
543734008436	intermolecular recognition site; other site
543734008437	dimerization interface [polypeptide binding]; other site
543734008438	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
543734008439	DNA binding site [nucleotide binding]
543734008440	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
543734008441	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
543734008442	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
543734008443	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
543734008444	substrate binding pocket [chemical binding]; other site
543734008445	membrane-bound complex binding site; other site
543734008446	hinge residues; other site
543734008447	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
543734008448	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734008449	dimer interface [polypeptide binding]; other site
543734008450	conserved gate region; other site
543734008451	putative PBP binding loops; other site
543734008452	ABC-ATPase subunit interface; other site
543734008453	argininosuccinate synthase; Provisional; Region: PRK13820
543734008454	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
543734008455	ANP binding site [chemical binding]; other site
543734008456	Substrate Binding Site II [chemical binding]; other site
543734008457	Substrate Binding Site I [chemical binding]; other site
543734008458	argininosuccinate lyase; Provisional; Region: PRK00855
543734008459	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
543734008460	active sites [active]
543734008461	tetramer interface [polypeptide binding]; other site
543734008462	Uncharacterized conserved protein [Function unknown]; Region: COG3589
543734008463	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
543734008464	Domain of unknown function (DUF3284); Region: DUF3284; pfam11687
543734008465	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
543734008466	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
543734008467	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
543734008468	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
543734008469	DNA-binding site [nucleotide binding]; DNA binding site
543734008470	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
543734008471	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
543734008472	active site
543734008473	P-loop; other site
543734008474	phosphorylation site [posttranslational modification]
543734008475	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
543734008476	active site
543734008477	methionine cluster; other site
543734008478	phosphorylation site [posttranslational modification]
543734008479	metal binding site [ion binding]; metal-binding site
543734008480	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
543734008481	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
543734008482	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
543734008483	nudix motif; other site
543734008484	hypothetical protein; Provisional; Region: PRK06762
543734008485	AAA domain; Region: AAA_33; pfam13671
543734008486	Isochorismatase family; Region: Isochorismatase; pfam00857
543734008487	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
543734008488	catalytic triad [active]
543734008489	dimer interface [polypeptide binding]; other site
543734008490	conserved cis-peptide bond; other site
543734008491	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734008492	Major Facilitator Superfamily; Region: MFS_1; pfam07690
543734008493	putative substrate translocation pore; other site
543734008494	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734008495	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
543734008496	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734008497	putative substrate translocation pore; other site
543734008498	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
543734008499	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
543734008500	active site
543734008501	catalytic tetrad [active]
543734008502	Domain of unknown function (DUF956); Region: DUF956; pfam06115
543734008503	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
543734008504	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
543734008505	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
543734008506	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
543734008507	active pocket/dimerization site; other site
543734008508	active site
543734008509	phosphorylation site [posttranslational modification]
543734008510	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
543734008511	active site
543734008512	phosphorylation site [posttranslational modification]
543734008513	H+ Antiporter protein; Region: 2A0121; TIGR00900
543734008514	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
543734008515	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734008516	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
543734008517	non-specific DNA binding site [nucleotide binding]; other site
543734008518	salt bridge; other site
543734008519	sequence-specific DNA binding site [nucleotide binding]; other site
543734008520	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
543734008521	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
543734008522	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734008523	non-specific DNA binding site [nucleotide binding]; other site
543734008524	salt bridge; other site
543734008525	sequence-specific DNA binding site [nucleotide binding]; other site
543734008526	Helix-turn-helix domain; Region: HTH_19; pfam12844
543734008527	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
543734008528	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
543734008529	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
543734008530	substrate binding pocket [chemical binding]; other site
543734008531	membrane-bound complex binding site; other site
543734008532	hinge residues; other site
543734008533	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
543734008534	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734008535	dimer interface [polypeptide binding]; other site
543734008536	conserved gate region; other site
543734008537	putative PBP binding loops; other site
543734008538	ABC-ATPase subunit interface; other site
543734008539	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
543734008540	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
543734008541	Walker A/P-loop; other site
543734008542	ATP binding site [chemical binding]; other site
543734008543	Q-loop/lid; other site
543734008544	ABC transporter signature motif; other site
543734008545	Walker B; other site
543734008546	D-loop; other site
543734008547	H-loop/switch region; other site
543734008548	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
543734008549	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
543734008550	Protein of unknown function (DUF975); Region: DUF975; cl10504
543734008551	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918
543734008552	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
543734008553	Uncharacterized conserved protein [Function unknown]; Region: COG3402
543734008554	Predicted membrane protein [Function unknown]; Region: COG3428
543734008555	Bacterial PH domain; Region: DUF304; pfam03703
543734008556	Bacterial PH domain; Region: DUF304; pfam03703
543734008557	Bacterial PH domain; Region: DUF304; cl01348
543734008558	Predicted ATPase [General function prediction only]; Region: COG3910
543734008559	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
543734008560	Walker A/P-loop; other site
543734008561	ATP binding site [chemical binding]; other site
543734008562	Q-loop/lid; other site
543734008563	ABC transporter signature motif; other site
543734008564	Walker B; other site
543734008565	D-loop; other site
543734008566	H-loop/switch region; other site
543734008567	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
543734008568	Phosphotransferase enzyme family; Region: APH; pfam01636
543734008569	active site
543734008570	ATP binding site [chemical binding]; other site
543734008571	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
543734008572	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
543734008573	Walker A/P-loop; other site
543734008574	ATP binding site [chemical binding]; other site
543734008575	Q-loop/lid; other site
543734008576	ABC transporter signature motif; other site
543734008577	Walker B; other site
543734008578	D-loop; other site
543734008579	H-loop/switch region; other site
543734008580	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
543734008581	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
543734008582	substrate binding pocket [chemical binding]; other site
543734008583	membrane-bound complex binding site; other site
543734008584	hinge residues; other site
543734008585	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734008586	dimer interface [polypeptide binding]; other site
543734008587	conserved gate region; other site
543734008588	putative PBP binding loops; other site
543734008589	ABC-ATPase subunit interface; other site
543734008590	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
543734008591	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
543734008592	substrate binding pocket [chemical binding]; other site
543734008593	membrane-bound complex binding site; other site
543734008594	hinge residues; other site
543734008595	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
543734008596	dimer interface [polypeptide binding]; other site
543734008597	conserved gate region; other site
543734008598	putative PBP binding loops; other site
543734008599	ABC-ATPase subunit interface; other site
543734008600	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
543734008601	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
543734008602	Integral membrane protein DUF95; Region: DUF95; pfam01944
543734008603	MoxR-like ATPases [General function prediction only]; Region: COG0714
543734008604	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
543734008605	Walker A motif; other site
543734008606	ATP binding site [chemical binding]; other site
543734008607	Walker B motif; other site
543734008608	MoxR-like ATPases [General function prediction only]; Region: COG0714
543734008609	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
543734008610	Protein of unknown function DUF58; Region: DUF58; pfam01882
543734008611	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
543734008612	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
543734008613	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
543734008614	putative ADP-binding pocket [chemical binding]; other site
543734008615	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
543734008616	maltose O-acetyltransferase; Provisional; Region: PRK10092
543734008617	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
543734008618	active site
543734008619	substrate binding site [chemical binding]; other site
543734008620	trimer interface [polypeptide binding]; other site
543734008621	CoA binding site [chemical binding]; other site
543734008622	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734008623	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
543734008624	active site
543734008625	motif I; other site
543734008626	motif II; other site
543734008627	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734008628	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
543734008629	Aspartase; Region: Aspartase; cd01357
543734008630	active sites [active]
543734008631	tetramer interface [polypeptide binding]; other site
543734008632	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
543734008633	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
543734008634	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
543734008635	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
543734008636	Malic enzyme, N-terminal domain; Region: malic; pfam00390
543734008637	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
543734008638	putative NAD(P) binding site [chemical binding]; other site
543734008639	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
543734008640	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
543734008641	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
543734008642	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
543734008643	active site
543734008644	phosphorylation site [posttranslational modification]
543734008645	intermolecular recognition site; other site
543734008646	dimerization interface [polypeptide binding]; other site
543734008647	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
543734008648	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
543734008649	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
543734008650	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
543734008651	Agrin NtA domain; Region: NtA; pfam03146
543734008652	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
543734008653	Int/Topo IB signature motif; other site
543734008654	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
543734008655	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
543734008656	non-specific DNA binding site [nucleotide binding]; other site
543734008657	salt bridge; other site
543734008658	sequence-specific DNA binding site [nucleotide binding]; other site
543734008659	Helix-turn-helix domain; Region: HTH_17; pfam12728
543734008660	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
543734008661	polymerase nucleotide-binding site; other site
543734008662	DNA-binding residues [nucleotide binding]; DNA binding site
543734008663	nucleotide binding site [chemical binding]; other site
543734008664	primase nucleotide-binding site [nucleotide binding]; other site
543734008665	Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942
543734008666	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
543734008667	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
543734008668	Phage terminase, small subunit; Region: Terminase_4; pfam05119
543734008669	Phage Terminase; Region: Terminase_1; pfam03354
543734008670	Phage portal protein; Region: Phage_portal; pfam04860
543734008671	Phage-related protein [Function unknown]; Region: COG4695; cl01923
543734008672	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
543734008673	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
543734008674	Phage capsid family; Region: Phage_capsid; pfam05065
543734008675	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
543734008676	oligomerization interface [polypeptide binding]; other site
543734008677	Predicted membrane protein [Function unknown]; Region: COG2261
543734008678	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
543734008679	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
543734008680	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
543734008681	active site
543734008682	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
543734008683	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
543734008684	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
543734008685	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
543734008686	substrate binding pocket [chemical binding]; other site
543734008687	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
543734008688	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
543734008689	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
543734008690	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
543734008691	active site
543734008692	phosphorylation site [posttranslational modification]
543734008693	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
543734008694	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
543734008695	Mga helix-turn-helix domain; Region: Mga; pfam05043
543734008696	DNA-binding interface [nucleotide binding]; DNA binding site
543734008697	PRD domain; Region: PRD; pfam00874
543734008698	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
543734008699	active site
543734008700	P-loop; other site
543734008701	phosphorylation site [posttranslational modification]
543734008702	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
543734008703	active site
543734008704	phosphorylation site [posttranslational modification]
543734008705	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
543734008706	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
543734008707	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
543734008708	active site
543734008709	P-loop; other site
543734008710	phosphorylation site [posttranslational modification]
543734008711	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
543734008712	active site
543734008713	P-loop; other site
543734008714	phosphorylation site [posttranslational modification]
543734008715	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
543734008716	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
543734008717	active site
543734008718	trimer interface [polypeptide binding]; other site
543734008719	allosteric site; other site
543734008720	active site lid [active]
543734008721	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
543734008722	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
543734008723	active site
543734008724	motif I; other site
543734008725	motif II; other site
543734008726	HlyD family secretion protein; Region: HlyD_2; pfam12700
543734008727	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
543734008728	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
543734008729	Walker A/P-loop; other site
543734008730	ATP binding site [chemical binding]; other site
543734008731	Q-loop/lid; other site
543734008732	ABC transporter signature motif; other site
543734008733	Walker B; other site
543734008734	D-loop; other site
543734008735	H-loop/switch region; other site
543734008736	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
543734008737	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
543734008738	FtsX-like permease family; Region: FtsX; pfam02687
543734008739	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
543734008740	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
543734008741	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
543734008742	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
543734008743	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
543734008744	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
543734008745	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
543734008746	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
543734008747	putative active site [active]
543734008748	metal binding site [ion binding]; metal-binding site
543734008749	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
543734008750	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
543734008751	metal binding site [ion binding]; metal-binding site
543734008752	dimer interface [polypeptide binding]; other site
543734008753	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
543734008754	Uncharacterized conserved protein [Function unknown]; Region: COG2966
543734008755	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
543734008756	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
543734008757	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
543734008758	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
543734008759	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
543734008760	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
543734008761	trmE is a tRNA modification GTPase; Region: trmE; cd04164
543734008762	G1 box; other site
543734008763	GTP/Mg2+ binding site [chemical binding]; other site
543734008764	Switch I region; other site
543734008765	G2 box; other site
543734008766	Switch II region; other site
543734008767	G3 box; other site
543734008768	G4 box; other site
543734008769	G5 box; other site
543734008770	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
543734008771	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
543734008772	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
543734008773	G-X-X-G motif; other site
543734008774	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
543734008775	RxxxH motif; other site
543734008776	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
543734008777	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
543734008778	ribonuclease P; Reviewed; Region: rnpA; PRK00499
543734008779	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399