-- dump date 20140619_122859 -- class Genbank::misc_feature -- table misc_feature_note -- id note 999378000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 999378000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999378000003 Walker A motif; other site 999378000004 ATP binding site [chemical binding]; other site 999378000005 Walker B motif; other site 999378000006 arginine finger; other site 999378000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 999378000008 DnaA box-binding interface [nucleotide binding]; other site 999378000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 999378000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 999378000011 putative DNA binding surface [nucleotide binding]; other site 999378000012 dimer interface [polypeptide binding]; other site 999378000013 beta-clamp/clamp loader binding surface; other site 999378000014 beta-clamp/translesion DNA polymerase binding surface; other site 999378000015 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 999378000016 recombination protein F; Reviewed; Region: recF; PRK00064 999378000017 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 999378000018 Walker A/P-loop; other site 999378000019 ATP binding site [chemical binding]; other site 999378000020 Q-loop/lid; other site 999378000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378000022 ABC transporter signature motif; other site 999378000023 Walker B; other site 999378000024 D-loop; other site 999378000025 H-loop/switch region; other site 999378000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 999378000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999378000028 Mg2+ binding site [ion binding]; other site 999378000029 G-X-G motif; other site 999378000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 999378000031 anchoring element; other site 999378000032 dimer interface [polypeptide binding]; other site 999378000033 ATP binding site [chemical binding]; other site 999378000034 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 999378000035 active site 999378000036 metal binding site [ion binding]; metal-binding site 999378000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 999378000038 DNA gyrase subunit A; Validated; Region: PRK05560 999378000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 999378000040 CAP-like domain; other site 999378000041 active site 999378000042 primary dimer interface [polypeptide binding]; other site 999378000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 999378000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 999378000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 999378000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 999378000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 999378000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 999378000049 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 999378000050 intersubunit interface [polypeptide binding]; other site 999378000051 active site 999378000052 catalytic residue [active] 999378000053 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 999378000054 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 999378000055 dimer interface [polypeptide binding]; other site 999378000056 ssDNA binding site [nucleotide binding]; other site 999378000057 tetramer (dimer of dimers) interface [polypeptide binding]; other site 999378000058 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 999378000059 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 999378000060 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 999378000061 dimer interface [polypeptide binding]; other site 999378000062 ssDNA binding site [nucleotide binding]; other site 999378000063 tetramer (dimer of dimers) interface [polypeptide binding]; other site 999378000064 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 999378000065 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 999378000066 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 999378000067 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 999378000068 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 999378000069 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 999378000070 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 999378000071 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 999378000072 CAAX protease self-immunity; Region: Abi; pfam02517 999378000073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 999378000074 Surface antigen [General function prediction only]; Region: COG3942 999378000075 CHAP domain; Region: CHAP; pfam05257 999378000076 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 999378000077 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 999378000078 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 999378000079 FtsX-like permease family; Region: FtsX; pfam02687 999378000080 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 999378000081 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 999378000082 Walker A/P-loop; other site 999378000083 ATP binding site [chemical binding]; other site 999378000084 Q-loop/lid; other site 999378000085 ABC transporter signature motif; other site 999378000086 Walker B; other site 999378000087 D-loop; other site 999378000088 H-loop/switch region; other site 999378000089 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 999378000090 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999378000091 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378000092 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 999378000093 active site 999378000094 motif I; other site 999378000095 motif II; other site 999378000096 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 999378000097 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 999378000098 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 999378000099 active site 999378000100 hypothetical protein; Provisional; Region: PRK10621 999378000101 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 999378000102 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 999378000103 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 999378000104 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 999378000105 Cl binding site [ion binding]; other site 999378000106 oligomer interface [polypeptide binding]; other site 999378000107 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999378000108 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999378000109 manganese transport protein MntH; Reviewed; Region: PRK00701 999378000110 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 999378000111 Peptidase family C69; Region: Peptidase_C69; pfam03577 999378000112 Enterocin A Immunity; Region: EntA_Immun; pfam08951 999378000113 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 999378000114 Transcriptional regulators [Transcription]; Region: GntR; COG1802 999378000115 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999378000116 DNA-binding site [nucleotide binding]; DNA binding site 999378000117 FCD domain; Region: FCD; pfam07729 999378000118 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999378000119 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999378000120 non-specific DNA binding site [nucleotide binding]; other site 999378000121 salt bridge; other site 999378000122 sequence-specific DNA binding site [nucleotide binding]; other site 999378000123 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 999378000124 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 999378000125 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999378000126 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 999378000127 Walker A/P-loop; other site 999378000128 ATP binding site [chemical binding]; other site 999378000129 Q-loop/lid; other site 999378000130 ABC transporter signature motif; other site 999378000131 Walker B; other site 999378000132 D-loop; other site 999378000133 H-loop/switch region; other site 999378000134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378000135 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999378000136 putative substrate translocation pore; other site 999378000137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378000138 Predicted membrane protein [General function prediction only]; Region: COG4194 999378000139 MMPL family; Region: MMPL; pfam03176 999378000140 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 999378000141 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 999378000142 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999378000143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378000144 putative PBP binding loops; other site 999378000145 dimer interface [polypeptide binding]; other site 999378000146 ABC-ATPase subunit interface; other site 999378000147 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 999378000148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378000149 dimer interface [polypeptide binding]; other site 999378000150 conserved gate region; other site 999378000151 putative PBP binding loops; other site 999378000152 ABC-ATPase subunit interface; other site 999378000153 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 999378000154 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 999378000155 Walker A/P-loop; other site 999378000156 ATP binding site [chemical binding]; other site 999378000157 Q-loop/lid; other site 999378000158 ABC transporter signature motif; other site 999378000159 Walker B; other site 999378000160 D-loop; other site 999378000161 H-loop/switch region; other site 999378000162 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 999378000163 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 999378000164 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 999378000165 substrate binding site [chemical binding]; other site 999378000166 active site 999378000167 catalytic residues [active] 999378000168 heterodimer interface [polypeptide binding]; other site 999378000169 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 999378000170 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 999378000171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999378000172 catalytic residue [active] 999378000173 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 999378000174 active site 999378000175 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 999378000176 active site 999378000177 ribulose/triose binding site [chemical binding]; other site 999378000178 phosphate binding site [ion binding]; other site 999378000179 substrate (anthranilate) binding pocket [chemical binding]; other site 999378000180 product (indole) binding pocket [chemical binding]; other site 999378000181 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 999378000182 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 999378000183 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 999378000184 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 999378000185 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 999378000186 active site 999378000187 P-loop; other site 999378000188 phosphorylation site [posttranslational modification] 999378000189 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 999378000190 active site 999378000191 phosphorylation site [posttranslational modification] 999378000192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378000193 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999378000194 putative substrate translocation pore; other site 999378000195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378000196 putative substrate translocation pore; other site 999378000197 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999378000198 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999378000199 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 999378000200 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 999378000201 Walker A/P-loop; other site 999378000202 ATP binding site [chemical binding]; other site 999378000203 Q-loop/lid; other site 999378000204 ABC transporter signature motif; other site 999378000205 Walker B; other site 999378000206 D-loop; other site 999378000207 H-loop/switch region; other site 999378000208 PemK-like protein; Region: PemK; pfam02452 999378000209 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 999378000210 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 999378000211 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 999378000212 active site 999378000213 dihydrodipicolinate reductase; Provisional; Region: PRK00048 999378000214 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 999378000215 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 999378000216 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 999378000217 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 999378000218 dimer interface [polypeptide binding]; other site 999378000219 active site 999378000220 catalytic residue [active] 999378000221 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 999378000222 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 999378000223 metal binding site [ion binding]; metal-binding site 999378000224 putative dimer interface [polypeptide binding]; other site 999378000225 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 999378000226 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 999378000227 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 999378000228 putative trimer interface [polypeptide binding]; other site 999378000229 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 999378000230 putative CoA binding site [chemical binding]; other site 999378000231 putative trimer interface [polypeptide binding]; other site 999378000232 putative CoA binding site [chemical binding]; other site 999378000233 diaminopimelate decarboxylase; Region: lysA; TIGR01048 999378000234 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 999378000235 active site 999378000236 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 999378000237 substrate binding site [chemical binding]; other site 999378000238 catalytic residues [active] 999378000239 dimer interface [polypeptide binding]; other site 999378000240 aspartate kinase; Reviewed; Region: PRK09034 999378000241 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 999378000242 putative catalytic residues [active] 999378000243 putative nucleotide binding site [chemical binding]; other site 999378000244 putative aspartate binding site [chemical binding]; other site 999378000245 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 999378000246 allosteric regulatory residue; other site 999378000247 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 999378000248 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 999378000249 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 999378000250 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 999378000251 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 999378000252 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 999378000253 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 999378000254 nudix motif; other site 999378000255 EamA-like transporter family; Region: EamA; cl17759 999378000256 PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417 999378000257 catalytic residues [active] 999378000258 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 999378000259 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 999378000260 DHH family; Region: DHH; pfam01368 999378000261 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 999378000262 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 999378000263 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 999378000264 replicative DNA helicase; Provisional; Region: PRK05748 999378000265 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 999378000266 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 999378000267 Walker A motif; other site 999378000268 ATP binding site [chemical binding]; other site 999378000269 Walker B motif; other site 999378000270 DNA binding loops [nucleotide binding] 999378000271 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 999378000272 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 999378000273 GDP-binding site [chemical binding]; other site 999378000274 ACT binding site; other site 999378000275 IMP binding site; other site 999378000276 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 999378000277 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 999378000278 Soluble P-type ATPase [General function prediction only]; Region: COG4087 999378000279 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999378000280 dimerization interface [polypeptide binding]; other site 999378000281 putative DNA binding site [nucleotide binding]; other site 999378000282 putative Zn2+ binding site [ion binding]; other site 999378000283 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 999378000284 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 999378000285 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 999378000286 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 999378000287 Transcriptional regulator [Transcription]; Region: LysR; COG0583 999378000288 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 999378000289 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 999378000290 dimerization interface [polypeptide binding]; other site 999378000291 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999378000292 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999378000293 non-specific DNA binding site [nucleotide binding]; other site 999378000294 salt bridge; other site 999378000295 sequence-specific DNA binding site [nucleotide binding]; other site 999378000296 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 999378000297 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 999378000298 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 999378000299 Walker A/P-loop; other site 999378000300 ATP binding site [chemical binding]; other site 999378000301 Q-loop/lid; other site 999378000302 ABC transporter signature motif; other site 999378000303 Walker B; other site 999378000304 D-loop; other site 999378000305 H-loop/switch region; other site 999378000306 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 999378000307 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 999378000308 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 999378000309 ATP cone domain; Region: ATP-cone; pfam03477 999378000310 Class III ribonucleotide reductase; Region: RNR_III; cd01675 999378000311 effector binding site; other site 999378000312 active site 999378000313 Zn binding site [ion binding]; other site 999378000314 glycine loop; other site 999378000315 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999378000316 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999378000317 non-specific DNA binding site [nucleotide binding]; other site 999378000318 salt bridge; other site 999378000319 sequence-specific DNA binding site [nucleotide binding]; other site 999378000320 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 999378000321 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 999378000322 active site 999378000323 metal binding site [ion binding]; metal-binding site 999378000324 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 999378000325 FAD binding domain; Region: FAD_binding_4; pfam01565 999378000326 Transposase domain (DUF772); Region: DUF772; pfam05598 999378000327 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 999378000328 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 999378000329 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 999378000330 active site 999378000331 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 999378000332 putative dimer interface [polypeptide binding]; other site 999378000333 catalytic triad [active] 999378000334 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 999378000335 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 999378000336 ATP-grasp domain; Region: ATP-grasp_4; cl17255 999378000337 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 999378000338 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 999378000339 DNA binding site [nucleotide binding] 999378000340 active site 999378000341 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 999378000342 D-lactate dehydrogenase; Validated; Region: PRK08605 999378000343 homodimer interface [polypeptide binding]; other site 999378000344 ligand binding site [chemical binding]; other site 999378000345 NAD binding site [chemical binding]; other site 999378000346 catalytic site [active] 999378000347 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 999378000348 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 999378000349 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 999378000350 NAD(P) binding site [chemical binding]; other site 999378000351 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 999378000352 Protein of unknown function (DUF1516); Region: DUF1516; pfam07457 999378000353 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 999378000354 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 999378000355 Helix-turn-helix domain; Region: HTH_38; pfam13936 999378000356 Integrase core domain; Region: rve; pfam00665 999378000357 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 999378000358 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 999378000359 Zn binding site [ion binding]; other site 999378000360 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 999378000361 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 999378000362 WxL domain surface cell wall-binding; Region: WxL; pfam13731 999378000363 WxL domain surface cell wall-binding; Region: WxL; pfam13731 999378000364 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 999378000365 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 999378000366 Mga helix-turn-helix domain; Region: Mga; pfam05043 999378000367 Protein of unknown function (DUF805); Region: DUF805; pfam05656 999378000368 Protein of unknown function (DUF805); Region: DUF805; pfam05656 999378000369 recombination factor protein RarA; Reviewed; Region: PRK13342 999378000370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999378000371 Walker A motif; other site 999378000372 ATP binding site [chemical binding]; other site 999378000373 Walker B motif; other site 999378000374 arginine finger; other site 999378000375 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 999378000376 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 999378000377 propionate/acetate kinase; Provisional; Region: PRK12379 999378000378 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 999378000379 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 999378000380 active site 999378000381 metal binding site [ion binding]; metal-binding site 999378000382 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 999378000383 endonuclease III; Region: ENDO3c; smart00478 999378000384 minor groove reading motif; other site 999378000385 helix-hairpin-helix signature motif; other site 999378000386 substrate binding pocket [chemical binding]; other site 999378000387 active site 999378000388 Domain of unknown function DUF77; Region: DUF77; pfam01910 999378000389 Predicted membrane protein [Function unknown]; Region: COG1511 999378000390 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 999378000391 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 999378000392 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 999378000393 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 999378000394 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999378000395 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999378000396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378000397 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999378000398 putative substrate translocation pore; other site 999378000399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378000400 putative phosphoketolase; Provisional; Region: PRK05261 999378000401 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 999378000402 TPP-binding site; other site 999378000403 XFP C-terminal domain; Region: XFP_C; pfam09363 999378000404 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 999378000405 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 999378000406 peptide binding site [polypeptide binding]; other site 999378000407 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 999378000408 nudix motif; other site 999378000409 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 999378000410 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 999378000411 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 999378000412 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 999378000413 Repair protein; Region: Repair_PSII; pfam04536 999378000414 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 999378000415 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 999378000416 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 999378000417 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 999378000418 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 999378000419 putative ligand binding site [chemical binding]; other site 999378000420 putative NAD binding site [chemical binding]; other site 999378000421 catalytic site [active] 999378000422 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 999378000423 Predicted membrane protein [Function unknown]; Region: COG2261 999378000424 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 999378000425 Asp23 family; Region: Asp23; pfam03780 999378000426 Asp23 family; Region: Asp23; pfam03780 999378000427 Protein of unknown function (DUF969); Region: DUF969; pfam06149 999378000428 Predicted membrane protein [Function unknown]; Region: COG3817 999378000429 Protein of unknown function (DUF979); Region: DUF979; pfam06166 999378000430 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 999378000431 putative substrate binding pocket [chemical binding]; other site 999378000432 AC domain interface; other site 999378000433 catalytic triad [active] 999378000434 AB domain interface; other site 999378000435 interchain disulfide; other site 999378000436 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 999378000437 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 999378000438 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 999378000439 catalytic triad [active] 999378000440 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 999378000441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999378000442 S-adenosylmethionine binding site [chemical binding]; other site 999378000443 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 999378000444 ParB-like nuclease domain; Region: ParBc; pfam02195 999378000445 KorB domain; Region: KorB; pfam08535 999378000446 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 999378000447 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 999378000448 P-loop; other site 999378000449 Magnesium ion binding site [ion binding]; other site 999378000450 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 999378000451 Magnesium ion binding site [ion binding]; other site 999378000452 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 999378000453 ParB-like nuclease domain; Region: ParB; smart00470 999378000454 KorB domain; Region: KorB; pfam08535 999378000455 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 999378000456 GTP-binding protein YchF; Reviewed; Region: PRK09601 999378000457 YchF GTPase; Region: YchF; cd01900 999378000458 G1 box; other site 999378000459 GTP/Mg2+ binding site [chemical binding]; other site 999378000460 Switch I region; other site 999378000461 G2 box; other site 999378000462 Switch II region; other site 999378000463 G3 box; other site 999378000464 G4 box; other site 999378000465 G5 box; other site 999378000466 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 999378000467 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 999378000468 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 999378000469 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 999378000470 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 999378000471 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 999378000472 active site 999378000473 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 999378000474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999378000475 active site 999378000476 phosphorylation site [posttranslational modification] 999378000477 intermolecular recognition site; other site 999378000478 dimerization interface [polypeptide binding]; other site 999378000479 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 999378000480 DNA binding site [nucleotide binding] 999378000481 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 999378000482 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 999378000483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 999378000484 dimer interface [polypeptide binding]; other site 999378000485 phosphorylation site [posttranslational modification] 999378000486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999378000487 ATP binding site [chemical binding]; other site 999378000488 Mg2+ binding site [ion binding]; other site 999378000489 G-X-G motif; other site 999378000490 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 999378000491 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 999378000492 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 999378000493 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 999378000494 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 999378000495 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 999378000496 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 999378000497 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 999378000498 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 999378000499 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 999378000500 aspartate racemase; Region: asp_race; TIGR00035 999378000501 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 999378000502 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 999378000503 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 999378000504 active site 999378000505 catalytic tetrad [active] 999378000506 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 999378000507 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 999378000508 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 999378000509 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 999378000510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378000511 putative substrate translocation pore; other site 999378000512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378000513 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 999378000514 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 999378000515 tetrameric interface [polypeptide binding]; other site 999378000516 NAD binding site [chemical binding]; other site 999378000517 catalytic residues [active] 999378000518 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 999378000519 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 999378000520 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 999378000521 substrate binding site [chemical binding]; other site 999378000522 ATP binding site [chemical binding]; other site 999378000523 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 999378000524 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 999378000525 PYR/PP interface [polypeptide binding]; other site 999378000526 dimer interface [polypeptide binding]; other site 999378000527 TPP binding site [chemical binding]; other site 999378000528 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 999378000529 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 999378000530 TPP-binding site; other site 999378000531 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 999378000532 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 999378000533 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 999378000534 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 999378000535 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 999378000536 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 999378000537 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 999378000538 Fructose-bisphosphate aldolase class-II; Region: F_bP_aldolase; pfam01116 999378000539 active site 999378000540 intersubunit interface [polypeptide binding]; other site 999378000541 zinc binding site [ion binding]; other site 999378000542 Na+ binding site [ion binding]; other site 999378000543 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 999378000544 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 999378000545 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 999378000546 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 999378000547 putative active site [active] 999378000548 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 999378000549 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 999378000550 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 999378000551 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 999378000552 N- and C-terminal domain interface [polypeptide binding]; other site 999378000553 active site 999378000554 catalytic site [active] 999378000555 metal binding site [ion binding]; metal-binding site 999378000556 carbohydrate binding site [chemical binding]; other site 999378000557 ATP binding site [chemical binding]; other site 999378000558 fructuronate transporter; Provisional; Region: PRK10034; cl15264 999378000559 Citrate transporter; Region: CitMHS; pfam03600 999378000560 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 999378000561 active site 999378000562 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 999378000563 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 999378000564 Probable Catalytic site; other site 999378000565 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 999378000566 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 999378000567 active site 999378000568 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 999378000569 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 999378000570 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 999378000571 active site 999378000572 SH3-like domain; Region: SH3_8; pfam13457 999378000573 SH3-like domain; Region: SH3_8; pfam13457 999378000574 SH3-like domain; Region: SH3_8; pfam13457 999378000575 SH3-like domain; Region: SH3_8; pfam13457 999378000576 SH3-like domain; Region: SH3_8; pfam13457 999378000577 SH3-like domain; Region: SH3_8; pfam13457 999378000578 SH3-like domain; Region: SH3_8; pfam13457 999378000579 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 999378000580 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 999378000581 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 999378000582 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 999378000583 active site 999378000584 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 999378000585 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 999378000586 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 999378000587 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 999378000588 putative PBP binding regions; other site 999378000589 ABC-ATPase subunit interface; other site 999378000590 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 999378000591 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 999378000592 active site 999378000593 metal binding site [ion binding]; metal-binding site 999378000594 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 999378000595 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 999378000596 oligoendopeptidase F; Region: pepF; TIGR00181 999378000597 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 999378000598 active site 999378000599 Zn binding site [ion binding]; other site 999378000600 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 999378000601 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 999378000602 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 999378000603 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 999378000604 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 999378000605 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 999378000606 active site 999378000607 Protein of unknown function (DUF975); Region: DUF975; cl10504 999378000608 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 999378000609 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 999378000610 Catalytic site [active] 999378000611 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 999378000612 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 999378000613 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 999378000614 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 999378000615 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 999378000616 ABC transporter; Region: ABC_tran_2; pfam12848 999378000617 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 999378000618 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 999378000619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999378000620 S-adenosylmethionine binding site [chemical binding]; other site 999378000621 Domain of unknown function (DUF4323); Region: DUF4323; pfam14211 999378000622 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 999378000623 catalytic residues [active] 999378000624 Uncharacterized conserved protein [Function unknown]; Region: COG2966 999378000625 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 999378000626 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 999378000627 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 999378000628 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 999378000629 putative ligand binding site [chemical binding]; other site 999378000630 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 999378000631 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 999378000632 TM-ABC transporter signature motif; other site 999378000633 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 999378000634 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 999378000635 Walker A/P-loop; other site 999378000636 ATP binding site [chemical binding]; other site 999378000637 Q-loop/lid; other site 999378000638 ABC transporter signature motif; other site 999378000639 Walker B; other site 999378000640 D-loop; other site 999378000641 H-loop/switch region; other site 999378000642 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 999378000643 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 999378000644 Walker A/P-loop; other site 999378000645 ATP binding site [chemical binding]; other site 999378000646 Q-loop/lid; other site 999378000647 ABC transporter signature motif; other site 999378000648 Walker B; other site 999378000649 D-loop; other site 999378000650 H-loop/switch region; other site 999378000651 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 999378000652 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 999378000653 Class I aldolases; Region: Aldolase_Class_I; cl17187 999378000654 catalytic residue [active] 999378000655 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 999378000656 intersubunit interface [polypeptide binding]; other site 999378000657 active site 999378000658 catalytic residue [active] 999378000659 phosphopentomutase; Provisional; Region: PRK05362 999378000660 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 999378000661 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 999378000662 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 999378000663 NlpC/P60 family; Region: NLPC_P60; pfam00877 999378000664 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 999378000665 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 999378000666 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 999378000667 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 999378000668 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 999378000669 DEAD/DEAH box helicase; Region: DEAD; pfam00270 999378000670 DEAD_2; Region: DEAD_2; pfam06733 999378000671 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 999378000672 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 999378000673 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 999378000674 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 999378000675 active site 999378000676 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 999378000677 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 999378000678 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 999378000679 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999378000680 DNA-binding site [nucleotide binding]; DNA binding site 999378000681 UTRA domain; Region: UTRA; pfam07702 999378000682 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 999378000683 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 999378000684 dimer interface [polypeptide binding]; other site 999378000685 active site 999378000686 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 999378000687 putative active site [active] 999378000688 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 999378000689 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 999378000690 active site 999378000691 dimer interface [polypeptide binding]; other site 999378000692 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 999378000693 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 999378000694 active site 999378000695 phosphorylation site [posttranslational modification] 999378000696 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 999378000697 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 999378000698 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 999378000699 active pocket/dimerization site; other site 999378000700 active site 999378000701 phosphorylation site [posttranslational modification] 999378000702 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 999378000703 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 999378000704 Transposase domain (DUF772); Region: DUF772; pfam05598 999378000705 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 999378000706 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 999378000707 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999378000708 homodimer interface [polypeptide binding]; other site 999378000709 catalytic residue [active] 999378000710 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 999378000711 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 999378000712 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 999378000713 active site 999378000714 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 999378000715 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 999378000716 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 999378000717 active site 999378000718 P-loop; other site 999378000719 phosphorylation site [posttranslational modification] 999378000720 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 999378000721 active site 999378000722 methionine cluster; other site 999378000723 phosphorylation site [posttranslational modification] 999378000724 metal binding site [ion binding]; metal-binding site 999378000725 exoaminopeptidase; Provisional; Region: PRK09961 999378000726 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 999378000727 oligomer interface [polypeptide binding]; other site 999378000728 active site 999378000729 metal binding site [ion binding]; metal-binding site 999378000730 HTH domain; Region: HTH_11; pfam08279 999378000731 PRD domain; Region: PRD; pfam00874 999378000732 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 999378000733 active site 999378000734 P-loop; other site 999378000735 phosphorylation site [posttranslational modification] 999378000736 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 999378000737 active site 999378000738 phosphorylation site [posttranslational modification] 999378000739 peptidase T; Region: peptidase-T; TIGR01882 999378000740 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 999378000741 metal binding site [ion binding]; metal-binding site 999378000742 dimer interface [polypeptide binding]; other site 999378000743 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 999378000744 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 999378000745 peptide binding site [polypeptide binding]; other site 999378000746 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 999378000747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999378000748 Coenzyme A binding pocket [chemical binding]; other site 999378000749 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 999378000750 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 999378000751 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 999378000752 Walker A/P-loop; other site 999378000753 ATP binding site [chemical binding]; other site 999378000754 Q-loop/lid; other site 999378000755 ABC transporter signature motif; other site 999378000756 Walker B; other site 999378000757 D-loop; other site 999378000758 H-loop/switch region; other site 999378000759 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 999378000760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378000761 Walker A/P-loop; other site 999378000762 ATP binding site [chemical binding]; other site 999378000763 Q-loop/lid; other site 999378000764 ABC transporter signature motif; other site 999378000765 Walker B; other site 999378000766 D-loop; other site 999378000767 H-loop/switch region; other site 999378000768 Cobalt transport protein; Region: CbiQ; cl00463 999378000769 Putative transcription activator [Transcription]; Region: TenA; COG0819 999378000770 Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952 999378000771 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 999378000772 substrate binding site [chemical binding]; other site 999378000773 multimerization interface [polypeptide binding]; other site 999378000774 ATP binding site [chemical binding]; other site 999378000775 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 999378000776 thiamine phosphate binding site [chemical binding]; other site 999378000777 active site 999378000778 pyrophosphate binding site [ion binding]; other site 999378000779 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 999378000780 dimer interface [polypeptide binding]; other site 999378000781 substrate binding site [chemical binding]; other site 999378000782 ATP binding site [chemical binding]; other site 999378000783 Amino acid permease; Region: AA_permease_2; pfam13520 999378000784 Transcriptional regulators [Transcription]; Region: PurR; COG1609 999378000785 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 999378000786 DNA binding site [nucleotide binding] 999378000787 domain linker motif; other site 999378000788 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 999378000789 ligand binding site [chemical binding]; other site 999378000790 dimerization interface [polypeptide binding]; other site 999378000791 D-ribose pyranase; Provisional; Region: PRK11797 999378000792 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 999378000793 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 999378000794 Walker A/P-loop; other site 999378000795 ATP binding site [chemical binding]; other site 999378000796 Q-loop/lid; other site 999378000797 ABC transporter signature motif; other site 999378000798 Walker B; other site 999378000799 D-loop; other site 999378000800 H-loop/switch region; other site 999378000801 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 999378000802 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 999378000803 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 999378000804 TM-ABC transporter signature motif; other site 999378000805 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 999378000806 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 999378000807 ligand binding site [chemical binding]; other site 999378000808 dimerization interface [polypeptide binding]; other site 999378000809 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 999378000810 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 999378000811 substrate binding site [chemical binding]; other site 999378000812 dimer interface [polypeptide binding]; other site 999378000813 ATP binding site [chemical binding]; other site 999378000814 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 999378000815 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 999378000816 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 999378000817 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 999378000818 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 999378000819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378000820 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999378000821 putative substrate translocation pore; other site 999378000822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378000823 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 999378000824 MarR family; Region: MarR_2; pfam12802 999378000825 Rhomboid family; Region: Rhomboid; cl11446 999378000826 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 999378000827 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378000828 ABC transporter signature motif; other site 999378000829 Walker B; other site 999378000830 D-loop; other site 999378000831 H-loop/switch region; other site 999378000832 Transposase domain (DUF772); Region: DUF772; pfam05598 999378000833 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 999378000834 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378000835 Walker A/P-loop; other site 999378000836 ATP binding site [chemical binding]; other site 999378000837 Q-loop/lid; other site 999378000838 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 999378000839 L-aspartate oxidase; Provisional; Region: PRK06175 999378000840 Predicted oxidoreductase [General function prediction only]; Region: COG3573 999378000841 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 999378000842 Mga helix-turn-helix domain; Region: Mga; pfam05043 999378000843 PRD domain; Region: PRD; pfam00874 999378000844 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 999378000845 active site 999378000846 phosphorylation site [posttranslational modification] 999378000847 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 999378000848 active site 999378000849 P-loop; other site 999378000850 phosphorylation site [posttranslational modification] 999378000851 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 999378000852 Fructose-bisphosphate aldolase class-II; Region: F_bP_aldolase; pfam01116 999378000853 active site 999378000854 intersubunit interface [polypeptide binding]; other site 999378000855 zinc binding site [ion binding]; other site 999378000856 Na+ binding site [ion binding]; other site 999378000857 AAA domain; Region: AAA_17; cl17253 999378000858 AAA domain; Region: AAA_18; pfam13238 999378000859 Predicted transcriptional regulators [Transcription]; Region: COG1378 999378000860 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 999378000861 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 999378000862 C-terminal domain interface [polypeptide binding]; other site 999378000863 sugar binding site [chemical binding]; other site 999378000864 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 999378000865 ornithine cyclodeaminase; Validated; Region: PRK08618 999378000866 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 999378000867 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 999378000868 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 999378000869 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 999378000870 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 999378000871 Helix-turn-helix domain; Region: HTH_38; pfam13936 999378000872 Integrase core domain; Region: rve; pfam00665 999378000873 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 999378000874 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 999378000875 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 999378000876 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 999378000877 Transposase; Region: DDE_Tnp_ISL3; pfam01610 999378000878 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 999378000879 conserved hypothetical protein; Region: TIGR02328 999378000880 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 999378000881 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 999378000882 Transcriptional regulators [Transcription]; Region: PurR; COG1609 999378000883 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 999378000884 DNA binding site [nucleotide binding] 999378000885 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 999378000886 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 999378000887 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 999378000888 Sulfatase; Region: Sulfatase; cl17466 999378000889 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 999378000890 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 999378000891 Helix-turn-helix domain; Region: HTH_38; pfam13936 999378000892 Integrase core domain; Region: rve; pfam00665 999378000893 Sulfatase; Region: Sulfatase; cl17466 999378000894 Uncharacterized conserved protein [Function unknown]; Region: COG1262 999378000895 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 999378000896 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 999378000897 anaerobic sulfatase-maturase; Provisional; Region: PRK13758 999378000898 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 999378000899 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 999378000900 active site 999378000901 tetramer interface [polypeptide binding]; other site 999378000902 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 999378000903 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 999378000904 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 999378000905 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 999378000906 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999378000907 DNA-binding site [nucleotide binding]; DNA binding site 999378000908 Predicted esterase [General function prediction only]; Region: COG0627 999378000909 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 999378000910 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 999378000911 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 999378000912 active site 999378000913 phosphorylation site [posttranslational modification] 999378000914 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 999378000915 active pocket/dimerization site; other site 999378000916 active site 999378000917 phosphorylation site [posttranslational modification] 999378000918 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 999378000919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999378000920 Walker A motif; other site 999378000921 ATP binding site [chemical binding]; other site 999378000922 Walker B motif; other site 999378000923 arginine finger; other site 999378000924 Transcriptional antiterminator [Transcription]; Region: COG3933 999378000925 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 999378000926 active pocket/dimerization site; other site 999378000927 active site 999378000928 phosphorylation site [posttranslational modification] 999378000929 PRD domain; Region: PRD; pfam00874 999378000930 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 999378000931 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 999378000932 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 999378000933 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 999378000934 HTH domain; Region: HTH_11; pfam08279 999378000935 Mga helix-turn-helix domain; Region: Mga; pfam05043 999378000936 PRD domain; Region: PRD; pfam00874 999378000937 PRD domain; Region: PRD; pfam00874 999378000938 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 999378000939 active site 999378000940 P-loop; other site 999378000941 phosphorylation site [posttranslational modification] 999378000942 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 999378000943 active site 999378000944 phosphorylation site [posttranslational modification] 999378000945 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 999378000946 intersubunit interface [polypeptide binding]; other site 999378000947 active site 999378000948 zinc binding site [ion binding]; other site 999378000949 Na+ binding site [ion binding]; other site 999378000950 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 999378000951 active site 999378000952 phosphorylation site [posttranslational modification] 999378000953 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 999378000954 active site 999378000955 P-loop; other site 999378000956 phosphorylation site [posttranslational modification] 999378000957 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 999378000958 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 999378000959 active site 999378000960 catalytic residues [active] 999378000961 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 999378000962 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 999378000963 N- and C-terminal domain interface [polypeptide binding]; other site 999378000964 D-xylulose kinase; Region: XylB; TIGR01312 999378000965 active site 999378000966 MgATP binding site [chemical binding]; other site 999378000967 catalytic site [active] 999378000968 metal binding site [ion binding]; metal-binding site 999378000969 xylulose binding site [chemical binding]; other site 999378000970 homodimer interface [polypeptide binding]; other site 999378000971 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 999378000972 Helix-turn-helix domain; Region: HTH_38; pfam13936 999378000973 Integrase core domain; Region: rve; pfam00665 999378000974 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 999378000975 active site 999378000976 phosphorylation site [posttranslational modification] 999378000977 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 999378000978 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 999378000979 active site 999378000980 P-loop; other site 999378000981 phosphorylation site [posttranslational modification] 999378000982 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 999378000983 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 999378000984 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 999378000985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999378000986 homodimer interface [polypeptide binding]; other site 999378000987 catalytic residue [active] 999378000988 putative frv operon regulatory protein; Provisional; Region: PRK09863 999378000989 HTH domain; Region: HTH_11; pfam08279 999378000990 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 999378000991 active site 999378000992 phosphorylation site [posttranslational modification] 999378000993 HTH domain; Region: HTH_11; pfam08279 999378000994 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 999378000995 PRD domain; Region: PRD; pfam00874 999378000996 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 999378000997 active site 999378000998 phosphorylation site [posttranslational modification] 999378000999 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 999378001000 intersubunit interface [polypeptide binding]; other site 999378001001 active site 999378001002 zinc binding site [ion binding]; other site 999378001003 Na+ binding site [ion binding]; other site 999378001004 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 999378001005 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 999378001006 active site 999378001007 phosphorylation site [posttranslational modification] 999378001008 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 999378001009 active site 999378001010 P-loop; other site 999378001011 phosphorylation site [posttranslational modification] 999378001012 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 999378001013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 999378001014 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 999378001015 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 999378001016 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 999378001017 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 999378001018 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 999378001019 classical (c) SDRs; Region: SDR_c; cd05233 999378001020 NAD(P) binding site [chemical binding]; other site 999378001021 active site 999378001022 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 999378001023 active pocket/dimerization site; other site 999378001024 active site 999378001025 phosphorylation site [posttranslational modification] 999378001026 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 999378001027 active site 999378001028 phosphorylation site [posttranslational modification] 999378001029 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 999378001030 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 999378001031 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 999378001032 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 999378001033 DAK2 domain; Region: Dak2; pfam02734 999378001034 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 999378001035 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 999378001036 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 999378001037 active site 999378001038 dimer interface [polypeptide binding]; other site 999378001039 magnesium binding site [ion binding]; other site 999378001040 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 999378001041 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 999378001042 tetramer interface [polypeptide binding]; other site 999378001043 active site 999378001044 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 999378001045 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999378001046 DNA-binding site [nucleotide binding]; DNA binding site 999378001047 UTRA domain; Region: UTRA; pfam07702 999378001048 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 999378001049 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 999378001050 putative NAD(P) binding site [chemical binding]; other site 999378001051 catalytic Zn binding site [ion binding]; other site 999378001052 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 999378001053 DNA binding residues [nucleotide binding] 999378001054 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 999378001055 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 999378001056 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 999378001057 classical (c) SDRs; Region: SDR_c; cd05233 999378001058 NAD(P) binding site [chemical binding]; other site 999378001059 active site 999378001060 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 999378001061 active pocket/dimerization site; other site 999378001062 active site 999378001063 phosphorylation site [posttranslational modification] 999378001064 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 999378001065 active site 999378001066 phosphorylation site [posttranslational modification] 999378001067 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 999378001068 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 999378001069 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 999378001070 intersubunit interface [polypeptide binding]; other site 999378001071 active site 999378001072 zinc binding site [ion binding]; other site 999378001073 Na+ binding site [ion binding]; other site 999378001074 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 999378001075 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 999378001076 transmembrane helices; other site 999378001077 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 999378001078 Transcriptional regulator [Transcription]; Region: LysR; COG0583 999378001079 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 999378001080 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 999378001081 dimerization interface [polypeptide binding]; other site 999378001082 Uncharacterized conserved protein [Function unknown]; Region: COG1912 999378001083 hypothetical protein; Provisional; Region: PRK13661 999378001084 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 999378001085 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 999378001086 Walker A/P-loop; other site 999378001087 ATP binding site [chemical binding]; other site 999378001088 Q-loop/lid; other site 999378001089 ABC transporter signature motif; other site 999378001090 Walker B; other site 999378001091 D-loop; other site 999378001092 H-loop/switch region; other site 999378001093 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 999378001094 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 999378001095 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 999378001096 Walker A/P-loop; other site 999378001097 ATP binding site [chemical binding]; other site 999378001098 Q-loop/lid; other site 999378001099 ABC transporter signature motif; other site 999378001100 Walker B; other site 999378001101 D-loop; other site 999378001102 H-loop/switch region; other site 999378001103 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 999378001104 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 999378001105 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 999378001106 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 999378001107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 999378001108 Transcriptional antiterminator [Transcription]; Region: COG3933 999378001109 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 999378001110 active pocket/dimerization site; other site 999378001111 active site 999378001112 phosphorylation site [posttranslational modification] 999378001113 PRD domain; Region: PRD; pfam00874 999378001114 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 999378001115 active pocket/dimerization site; other site 999378001116 active site 999378001117 phosphorylation site [posttranslational modification] 999378001118 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 999378001119 active site 999378001120 phosphorylation site [posttranslational modification] 999378001121 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 999378001122 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 999378001123 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 999378001124 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378001125 motif II; other site 999378001126 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 999378001127 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 999378001128 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 999378001129 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 999378001130 active site 999378001131 dimer interface [polypeptide binding]; other site 999378001132 magnesium binding site [ion binding]; other site 999378001133 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 999378001134 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 999378001135 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 999378001136 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 999378001137 active site 999378001138 P-loop; other site 999378001139 phosphorylation site [posttranslational modification] 999378001140 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 999378001141 active site 999378001142 phosphorylation site [posttranslational modification] 999378001143 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 999378001144 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 999378001145 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 999378001146 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 999378001147 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 999378001148 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 999378001149 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378001150 Walker A/P-loop; other site 999378001151 ATP binding site [chemical binding]; other site 999378001152 Q-loop/lid; other site 999378001153 ABC transporter signature motif; other site 999378001154 Walker B; other site 999378001155 D-loop; other site 999378001156 H-loop/switch region; other site 999378001157 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 999378001158 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 999378001159 substrate binding pocket [chemical binding]; other site 999378001160 membrane-bound complex binding site; other site 999378001161 hinge residues; other site 999378001162 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 999378001163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378001164 dimer interface [polypeptide binding]; other site 999378001165 conserved gate region; other site 999378001166 putative PBP binding loops; other site 999378001167 ABC-ATPase subunit interface; other site 999378001168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378001169 dimer interface [polypeptide binding]; other site 999378001170 conserved gate region; other site 999378001171 putative PBP binding loops; other site 999378001172 ABC-ATPase subunit interface; other site 999378001173 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 999378001174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378001175 putative substrate translocation pore; other site 999378001176 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 999378001177 YvrJ protein family; Region: YvrJ; pfam12841 999378001178 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 999378001179 active site 999378001180 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 999378001181 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999378001182 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 999378001183 classical (c) SDRs; Region: SDR_c; cd05233 999378001184 NAD(P) binding site [chemical binding]; other site 999378001185 active site 999378001186 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 999378001187 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999378001188 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999378001189 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 999378001190 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 999378001191 FtsX-like permease family; Region: FtsX; pfam02687 999378001192 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 999378001193 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 999378001194 Walker A/P-loop; other site 999378001195 ATP binding site [chemical binding]; other site 999378001196 Q-loop/lid; other site 999378001197 ABC transporter signature motif; other site 999378001198 Walker B; other site 999378001199 D-loop; other site 999378001200 H-loop/switch region; other site 999378001201 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999378001202 non-specific DNA binding site [nucleotide binding]; other site 999378001203 salt bridge; other site 999378001204 sequence-specific DNA binding site [nucleotide binding]; other site 999378001205 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 999378001206 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 999378001207 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 999378001208 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378001209 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 999378001210 active site 999378001211 motif I; other site 999378001212 motif II; other site 999378001213 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 999378001214 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 999378001215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 999378001216 Transcriptional regulators [Transcription]; Region: PurR; COG1609 999378001217 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 999378001218 DNA binding site [nucleotide binding] 999378001219 domain linker motif; other site 999378001220 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 999378001221 putative dimerization interface [polypeptide binding]; other site 999378001222 putative ligand binding site [chemical binding]; other site 999378001223 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 999378001224 active site 999378001225 phosphorylation site [posttranslational modification] 999378001226 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 999378001227 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 999378001228 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 999378001229 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 999378001230 putative active site [active] 999378001231 putative catalytic site [active] 999378001232 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 999378001233 active pocket/dimerization site; other site 999378001234 active site 999378001235 phosphorylation site [posttranslational modification] 999378001236 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 999378001237 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 999378001238 Ca binding site [ion binding]; other site 999378001239 active site 999378001240 catalytic site [active] 999378001241 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 999378001242 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378001243 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 999378001244 Walker A/P-loop; other site 999378001245 ATP binding site [chemical binding]; other site 999378001246 Q-loop/lid; other site 999378001247 ABC transporter signature motif; other site 999378001248 Walker B; other site 999378001249 D-loop; other site 999378001250 H-loop/switch region; other site 999378001251 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 999378001252 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999378001253 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 999378001254 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999378001255 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378001256 Walker A/P-loop; other site 999378001257 ATP binding site [chemical binding]; other site 999378001258 Q-loop/lid; other site 999378001259 ABC transporter signature motif; other site 999378001260 Walker B; other site 999378001261 D-loop; other site 999378001262 H-loop/switch region; other site 999378001263 Predicted membrane protein [Function unknown]; Region: COG1511 999378001264 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 999378001265 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 999378001266 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 999378001267 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 999378001268 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 999378001269 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 999378001270 active site 999378001271 myosin-cross-reactive antigen; Provisional; Region: PRK13977 999378001272 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 999378001273 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999378001274 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 999378001275 DAK2 domain; Region: Dak2; cl03685 999378001276 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 999378001277 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 999378001278 OsmC-like protein; Region: OsmC; cl00767 999378001279 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 999378001280 active site 999378001281 catalytic site [active] 999378001282 substrate binding site [chemical binding]; other site 999378001283 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999378001284 dimerization interface [polypeptide binding]; other site 999378001285 putative DNA binding site [nucleotide binding]; other site 999378001286 putative Zn2+ binding site [ion binding]; other site 999378001287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378001288 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 999378001289 putative substrate translocation pore; other site 999378001290 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 999378001291 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 999378001292 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 999378001293 intersubunit interface [polypeptide binding]; other site 999378001294 active site 999378001295 zinc binding site [ion binding]; other site 999378001296 Na+ binding site [ion binding]; other site 999378001297 pyruvate oxidase; Provisional; Region: PRK08611 999378001298 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 999378001299 PYR/PP interface [polypeptide binding]; other site 999378001300 dimer interface [polypeptide binding]; other site 999378001301 tetramer interface [polypeptide binding]; other site 999378001302 TPP binding site [chemical binding]; other site 999378001303 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 999378001304 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 999378001305 TPP-binding site [chemical binding]; other site 999378001306 Beta-lactamase; Region: Beta-lactamase; pfam00144 999378001307 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 999378001308 Methyltransferase domain; Region: Methyltransf_31; pfam13847 999378001309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999378001310 S-adenosylmethionine binding site [chemical binding]; other site 999378001311 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 999378001312 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 999378001313 catalytic triad [active] 999378001314 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 999378001315 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 999378001316 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 999378001317 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 999378001318 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 999378001319 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 999378001320 DNA binding residues [nucleotide binding] 999378001321 putative dimer interface [polypeptide binding]; other site 999378001322 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 999378001323 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 999378001324 active site 999378001325 catalytic tetrad [active] 999378001326 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 999378001327 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 999378001328 putative NAD(P) binding site [chemical binding]; other site 999378001329 dimer interface [polypeptide binding]; other site 999378001330 Predicted transcriptional regulators [Transcription]; Region: COG1733 999378001331 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 999378001332 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 999378001333 beta-galactosidase; Region: BGL; TIGR03356 999378001334 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 999378001335 active site 999378001336 methionine cluster; other site 999378001337 phosphorylation site [posttranslational modification] 999378001338 metal binding site [ion binding]; metal-binding site 999378001339 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 999378001340 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 999378001341 active site 999378001342 P-loop; other site 999378001343 phosphorylation site [posttranslational modification] 999378001344 HTH domain; Region: HTH_11; cl17392 999378001345 Mga helix-turn-helix domain; Region: Mga; pfam05043 999378001346 PRD domain; Region: PRD; pfam00874 999378001347 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 999378001348 active site 999378001349 phosphorylation site [posttranslational modification] 999378001350 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 999378001351 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 999378001352 catalytic residues [active] 999378001353 catalytic nucleophile [active] 999378001354 Presynaptic Site I dimer interface [polypeptide binding]; other site 999378001355 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 999378001356 Synaptic Flat tetramer interface [polypeptide binding]; other site 999378001357 Synaptic Site I dimer interface [polypeptide binding]; other site 999378001358 DNA binding site [nucleotide binding] 999378001359 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 999378001360 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 999378001361 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 999378001362 active site 999378001363 catalytic site [active] 999378001364 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 999378001365 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 999378001366 Walker A/P-loop; other site 999378001367 ATP binding site [chemical binding]; other site 999378001368 Q-loop/lid; other site 999378001369 ABC transporter signature motif; other site 999378001370 Walker B; other site 999378001371 D-loop; other site 999378001372 H-loop/switch region; other site 999378001373 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 999378001374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999378001375 active site 999378001376 phosphorylation site [posttranslational modification] 999378001377 intermolecular recognition site; other site 999378001378 dimerization interface [polypeptide binding]; other site 999378001379 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 999378001380 DNA binding site [nucleotide binding] 999378001381 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 999378001382 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 999378001383 dimerization interface [polypeptide binding]; other site 999378001384 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 999378001385 dimer interface [polypeptide binding]; other site 999378001386 phosphorylation site [posttranslational modification] 999378001387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999378001388 ATP binding site [chemical binding]; other site 999378001389 Mg2+ binding site [ion binding]; other site 999378001390 G-X-G motif; other site 999378001391 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 999378001392 Walker A/P-loop; other site 999378001393 ATP binding site [chemical binding]; other site 999378001394 ABC transporter; Region: ABC_tran; pfam00005 999378001395 Q-loop/lid; other site 999378001396 ABC transporter signature motif; other site 999378001397 Walker B; other site 999378001398 D-loop; other site 999378001399 H-loop/switch region; other site 999378001400 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 999378001401 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 999378001402 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 999378001403 catalytic triad [active] 999378001404 putative active site [active] 999378001405 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 999378001406 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 999378001407 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 999378001408 catalytic triad [active] 999378001409 putative active site [active] 999378001410 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 999378001411 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 999378001412 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 999378001413 Zn binding site [ion binding]; other site 999378001414 inner membrane transporter YjeM; Provisional; Region: PRK15238 999378001415 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 999378001416 Transcriptional regulator [Transcription]; Region: LysR; COG0583 999378001417 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 999378001418 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 999378001419 putative dimerization interface [polypeptide binding]; other site 999378001420 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 999378001421 classical (c) SDRs; Region: SDR_c; cd05233 999378001422 NAD(P) binding site [chemical binding]; other site 999378001423 active site 999378001424 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 999378001425 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 999378001426 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 999378001427 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 999378001428 shikimate binding site; other site 999378001429 NAD(P) binding site [chemical binding]; other site 999378001430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378001431 putative substrate translocation pore; other site 999378001432 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999378001433 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 999378001434 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 999378001435 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 999378001436 shikimate binding site; other site 999378001437 NAD(P) binding site [chemical binding]; other site 999378001438 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 999378001439 proposed active site lysine [active] 999378001440 conserved cys residue [active] 999378001441 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 999378001442 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 999378001443 dimer interface [polypeptide binding]; other site 999378001444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999378001445 catalytic residue [active] 999378001446 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 999378001447 Int/Topo IB signature motif; other site 999378001448 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 999378001449 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999378001450 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999378001451 non-specific DNA binding site [nucleotide binding]; other site 999378001452 salt bridge; other site 999378001453 sequence-specific DNA binding site [nucleotide binding]; other site 999378001454 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 999378001455 ORF6N domain; Region: ORF6N; pfam10543 999378001456 ORF6C domain; Region: ORF6C; pfam10552 999378001457 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 999378001458 Domain of unknown function (DUF771); Region: DUF771; pfam05595 999378001459 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 999378001460 Helix-turn-helix domain; Region: HTH_36; pfam13730 999378001461 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 999378001462 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 999378001463 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 999378001464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999378001465 Walker A motif; other site 999378001466 ATP binding site [chemical binding]; other site 999378001467 Walker B motif; other site 999378001468 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 999378001469 active site 999378001470 catalytic site [active] 999378001471 substrate binding site [chemical binding]; other site 999378001472 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 999378001473 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 999378001474 active site 999378001475 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 999378001476 Helix-turn-helix domain; Region: HTH_38; pfam13936 999378001477 Integrase core domain; Region: rve; pfam00665 999378001478 GcrA cell cycle regulator; Region: GcrA; cl11564 999378001479 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 999378001480 Transposase; Region: HTH_Tnp_1; pfam01527 999378001481 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 999378001482 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 999378001483 Homeodomain-like domain; Region: HTH_23; cl17451 999378001484 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 999378001485 Transposase; Region: HTH_Tnp_1; cl17663 999378001486 Helix-turn-helix domain; Region: HTH_28; pfam13518 999378001487 putative transposase OrfB; Reviewed; Region: PHA02517 999378001488 HTH-like domain; Region: HTH_21; pfam13276 999378001489 Integrase core domain; Region: rve; pfam00665 999378001490 Integrase core domain; Region: rve_3; pfam13683 999378001491 HTH-like domain; Region: HTH_21; pfam13276 999378001492 Integrase core domain; Region: rve; pfam00665 999378001493 Integrase core domain; Region: rve_3; cl15866 999378001494 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 999378001495 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 999378001496 generic binding surface II; other site 999378001497 generic binding surface I; other site 999378001498 AAA-like domain; Region: AAA_10; pfam12846 999378001499 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 999378001500 Walker A motif; other site 999378001501 ATP binding site [chemical binding]; other site 999378001502 Walker B motif; other site 999378001503 hypothetical protein; Provisional; Region: PRK12495 999378001504 AAA-like domain; Region: AAA_10; pfam12846 999378001505 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 999378001506 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 999378001507 NlpC/P60 family; Region: NLPC_P60; cl17555 999378001508 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 999378001509 catalytic residues [active] 999378001510 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 999378001511 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 999378001512 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 999378001513 Toprim-like; Region: Toprim_2; pfam13155 999378001514 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 999378001515 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 999378001516 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 999378001517 active site 999378001518 catalytic site [active] 999378001519 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 999378001520 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 999378001521 Cl- selectivity filter; other site 999378001522 Cl- binding residues [ion binding]; other site 999378001523 pore gating glutamate residue; other site 999378001524 dimer interface [polypeptide binding]; other site 999378001525 H+/Cl- coupling transport residue; other site 999378001526 TrkA-C domain; Region: TrkA_C; pfam02080 999378001527 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 999378001528 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 999378001529 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 999378001530 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 999378001531 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 999378001532 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 999378001533 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378001534 active site 999378001535 motif I; other site 999378001536 motif II; other site 999378001537 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 999378001538 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 999378001539 Integrase core domain; Region: rve; pfam00665 999378001540 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 999378001541 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 999378001542 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 999378001543 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 999378001544 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 999378001545 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 999378001546 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 999378001547 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 999378001548 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378001549 active site 999378001550 motif I; other site 999378001551 motif II; other site 999378001552 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 999378001553 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 999378001554 Integrase core domain; Region: rve; pfam00665 999378001555 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 999378001556 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 999378001557 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 999378001558 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 999378001559 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 999378001560 active site 999378001561 phosphorylation site [posttranslational modification] 999378001562 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 999378001563 active pocket/dimerization site; other site 999378001564 active site 999378001565 phosphorylation site [posttranslational modification] 999378001566 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 999378001567 intersubunit interface [polypeptide binding]; other site 999378001568 active site 999378001569 catalytic residue [active] 999378001570 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 999378001571 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999378001572 DNA-binding site [nucleotide binding]; DNA binding site 999378001573 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 999378001574 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 999378001575 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 999378001576 catalytic residues [active] 999378001577 catalytic nucleophile [active] 999378001578 Presynaptic Site I dimer interface [polypeptide binding]; other site 999378001579 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 999378001580 Synaptic Flat tetramer interface [polypeptide binding]; other site 999378001581 Synaptic Site I dimer interface [polypeptide binding]; other site 999378001582 DNA binding site [nucleotide binding] 999378001583 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 999378001584 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 999378001585 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 999378001586 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 999378001587 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 999378001588 HTH-like domain; Region: HTH_21; pfam13276 999378001589 DDE domain; Region: DDE_Tnp_IS240; pfam13610 999378001590 Integrase core domain; Region: rve; pfam00665 999378001591 Integrase core domain; Region: rve_3; pfam13683 999378001592 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 999378001593 Transposase; Region: HTH_Tnp_1; pfam01527 999378001594 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 999378001595 ApbE family; Region: ApbE; pfam02424 999378001596 Predicted flavoprotein [General function prediction only]; Region: COG0431 999378001597 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 999378001598 Predicted flavoprotein [General function prediction only]; Region: COG0431 999378001599 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 999378001600 PAS domain; Region: PAS_10; pfam13596 999378001601 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 999378001602 Transposase; Region: HTH_Tnp_1; pfam01527 999378001603 DDE domain; Region: DDE_Tnp_IS240; pfam13610 999378001604 Integrase core domain; Region: rve; pfam00665 999378001605 Integrase core domain; Region: rve_3; pfam13683 999378001606 D-lactate dehydrogenase; Provisional; Region: PRK11183 999378001607 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 999378001608 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 999378001609 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 999378001610 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 999378001611 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 999378001612 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 999378001613 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 999378001614 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 999378001615 transmembrane helices; other site 999378001616 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 999378001617 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 999378001618 Transposase; Region: HTH_Tnp_1; cl17663 999378001619 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 999378001620 active site 999378001621 Bacterial SH3 domain; Region: SH3_5; pfam08460 999378001622 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 999378001623 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999378001624 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 999378001625 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 999378001626 homodimer interface [polypeptide binding]; other site 999378001627 substrate-cofactor binding pocket; other site 999378001628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999378001629 catalytic residue [active] 999378001630 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 999378001631 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 999378001632 substrate binding pocket [chemical binding]; other site 999378001633 membrane-bound complex binding site; other site 999378001634 hinge residues; other site 999378001635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378001636 dimer interface [polypeptide binding]; other site 999378001637 conserved gate region; other site 999378001638 putative PBP binding loops; other site 999378001639 ABC-ATPase subunit interface; other site 999378001640 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 999378001641 WxL domain surface cell wall-binding; Region: WxL; pfam13731 999378001642 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 999378001643 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 999378001644 legume lectins; Region: lectin_L-type; cd01951 999378001645 homotetramer interaction site [polypeptide binding]; other site 999378001646 homodimer interaction site [polypeptide binding]; other site 999378001647 carbohydrate binding site [chemical binding]; other site 999378001648 metal binding site [ion binding]; metal-binding site 999378001649 WxL domain surface cell wall-binding; Region: WxL; pfam13731 999378001650 WxL domain surface cell wall-binding; Region: WxL; pfam13731 999378001651 WxL domain surface cell wall-binding; Region: WxL; pfam13731 999378001652 legume lectins; Region: lectin_L-type; cd01951 999378001653 homotetramer interaction site [polypeptide binding]; other site 999378001654 carbohydrate binding site [chemical binding]; other site 999378001655 metal binding site [ion binding]; metal-binding site 999378001656 WxL domain surface cell wall-binding; Region: WxL; pfam13731 999378001657 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 999378001658 EamA-like transporter family; Region: EamA; pfam00892 999378001659 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 999378001660 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 999378001661 Walker A/P-loop; other site 999378001662 ATP binding site [chemical binding]; other site 999378001663 Q-loop/lid; other site 999378001664 ABC transporter signature motif; other site 999378001665 Walker B; other site 999378001666 D-loop; other site 999378001667 H-loop/switch region; other site 999378001668 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 999378001669 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 999378001670 substrate binding site [chemical binding]; other site 999378001671 ATP binding site [chemical binding]; other site 999378001672 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 999378001673 FAD binding site [chemical binding]; other site 999378001674 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 999378001675 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 999378001676 THF binding site; other site 999378001677 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 999378001678 substrate binding site [chemical binding]; other site 999378001679 THF binding site; other site 999378001680 zinc-binding site [ion binding]; other site 999378001681 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 999378001682 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999378001683 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378001684 Walker A/P-loop; other site 999378001685 ATP binding site [chemical binding]; other site 999378001686 Q-loop/lid; other site 999378001687 ABC transporter signature motif; other site 999378001688 Walker B; other site 999378001689 D-loop; other site 999378001690 H-loop/switch region; other site 999378001691 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 999378001692 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999378001693 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 999378001694 Walker A/P-loop; other site 999378001695 ATP binding site [chemical binding]; other site 999378001696 Q-loop/lid; other site 999378001697 ABC transporter signature motif; other site 999378001698 Walker B; other site 999378001699 D-loop; other site 999378001700 H-loop/switch region; other site 999378001701 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 999378001702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378001703 putative substrate translocation pore; other site 999378001704 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 999378001705 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999378001706 DNA-binding site [nucleotide binding]; DNA binding site 999378001707 UTRA domain; Region: UTRA; pfam07702 999378001708 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 999378001709 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 999378001710 Ca binding site [ion binding]; other site 999378001711 active site 999378001712 catalytic site [active] 999378001713 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 999378001714 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 999378001715 HPr interaction site; other site 999378001716 glycerol kinase (GK) interaction site [polypeptide binding]; other site 999378001717 active site 999378001718 phosphorylation site [posttranslational modification] 999378001719 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 999378001720 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 999378001721 active site turn [active] 999378001722 phosphorylation site [posttranslational modification] 999378001723 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 999378001724 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 999378001725 serine/threonine transporter SstT; Provisional; Region: PRK13628 999378001726 amino acid transporter; Region: 2A0306; TIGR00909 999378001727 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 999378001728 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 999378001729 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 999378001730 NAD binding site [chemical binding]; other site 999378001731 dimer interface [polypeptide binding]; other site 999378001732 tetramer (dimer of dimers) interface [polypeptide binding]; other site 999378001733 substrate binding site [chemical binding]; other site 999378001734 glutamate dehydrogenase; Provisional; Region: PRK09414 999378001735 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 999378001736 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 999378001737 NAD(P) binding site [chemical binding]; other site 999378001738 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 999378001739 DNA-binding site [nucleotide binding]; DNA binding site 999378001740 RNA-binding motif; other site 999378001741 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 999378001742 OsmC-like protein; Region: OsmC; pfam02566 999378001743 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 999378001744 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 999378001745 ABC transporter; Region: ABC_tran_2; pfam12848 999378001746 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 999378001747 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 999378001748 NADH(P)-binding; Region: NAD_binding_10; pfam13460 999378001749 NAD(P) binding site [chemical binding]; other site 999378001750 putative active site [active] 999378001751 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 999378001752 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 999378001753 active site 999378001754 catalytic tetrad [active] 999378001755 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 999378001756 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 999378001757 LytTr DNA-binding domain; Region: LytTR; smart00850 999378001758 Predicted membrane protein [Function unknown]; Region: COG1511 999378001759 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 999378001760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378001761 Walker A/P-loop; other site 999378001762 ATP binding site [chemical binding]; other site 999378001763 Q-loop/lid; other site 999378001764 ABC transporter signature motif; other site 999378001765 Walker B; other site 999378001766 D-loop; other site 999378001767 H-loop/switch region; other site 999378001768 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 999378001769 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 999378001770 active site 999378001771 zinc binding site [ion binding]; other site 999378001772 hypothetical protein; Provisional; Region: PRK00967 999378001773 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 999378001774 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 999378001775 putative NAD(P) binding site [chemical binding]; other site 999378001776 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 999378001777 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 999378001778 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 999378001779 MgtC family; Region: MgtC; pfam02308 999378001780 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 999378001781 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 999378001782 Rhomboid family; Region: Rhomboid; cl11446 999378001783 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 999378001784 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378001785 Walker A/P-loop; other site 999378001786 ATP binding site [chemical binding]; other site 999378001787 ABC transporter signature motif; other site 999378001788 Walker B; other site 999378001789 D-loop; other site 999378001790 H-loop/switch region; other site 999378001791 ABC transporter; Region: ABC_tran_2; pfam12848 999378001792 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 999378001793 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378001794 Walker A/P-loop; other site 999378001795 ATP binding site [chemical binding]; other site 999378001796 Q-loop/lid; other site 999378001797 ABC transporter signature motif; other site 999378001798 Walker B; other site 999378001799 D-loop; other site 999378001800 H-loop/switch region; other site 999378001801 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 999378001802 putative uracil binding site [chemical binding]; other site 999378001803 putative active site [active] 999378001804 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 999378001805 amphipathic channel; other site 999378001806 Asn-Pro-Ala signature motifs; other site 999378001807 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 999378001808 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 999378001809 glycerol kinase; Provisional; Region: glpK; PRK00047 999378001810 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 999378001811 N- and C-terminal domain interface [polypeptide binding]; other site 999378001812 active site 999378001813 MgATP binding site [chemical binding]; other site 999378001814 catalytic site [active] 999378001815 metal binding site [ion binding]; metal-binding site 999378001816 glycerol binding site [chemical binding]; other site 999378001817 homotetramer interface [polypeptide binding]; other site 999378001818 homodimer interface [polypeptide binding]; other site 999378001819 FBP binding site [chemical binding]; other site 999378001820 protein IIAGlc interface [polypeptide binding]; other site 999378001821 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 999378001822 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 999378001823 active site 999378001824 CAT RNA binding domain; Region: CAT_RBD; pfam03123 999378001825 transcriptional antiterminator BglG; Provisional; Region: PRK09772 999378001826 PRD domain; Region: PRD; pfam00874 999378001827 PRD domain; Region: PRD; pfam00874 999378001828 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 999378001829 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 999378001830 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 999378001831 active site 999378001832 P-loop; other site 999378001833 phosphorylation site [posttranslational modification] 999378001834 6-phospho-beta-galactosidase; Region: lacG; TIGR01233 999378001835 beta-galactosidase; Region: BGL; TIGR03356 999378001836 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 999378001837 methionine cluster; other site 999378001838 active site 999378001839 phosphorylation site [posttranslational modification] 999378001840 metal binding site [ion binding]; metal-binding site 999378001841 galactokinase; Provisional; Region: PRK05322 999378001842 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 999378001843 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 999378001844 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 999378001845 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 999378001846 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 999378001847 NAD binding site [chemical binding]; other site 999378001848 homodimer interface [polypeptide binding]; other site 999378001849 active site 999378001850 substrate binding site [chemical binding]; other site 999378001851 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 999378001852 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 999378001853 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 999378001854 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 999378001855 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 999378001856 DNA binding site [nucleotide binding] 999378001857 domain linker motif; other site 999378001858 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 999378001859 putative dimerization interface [polypeptide binding]; other site 999378001860 putative ligand binding site [chemical binding]; other site 999378001861 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 999378001862 active site 999378001863 catalytic residues [active] 999378001864 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 999378001865 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 999378001866 active site 999378001867 phosphorylation site [posttranslational modification] 999378001868 Phosphotransferase system, galactitol-specific IIB component [Carbohydrate transport and metabolism]; Region: SgaB; COG3414 999378001869 active site 999378001870 P-loop; other site 999378001871 phosphorylation site [posttranslational modification] 999378001872 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 999378001873 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 999378001874 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 999378001875 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 999378001876 putative substrate binding site [chemical binding]; other site 999378001877 putative ATP binding site [chemical binding]; other site 999378001878 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 999378001879 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 999378001880 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 999378001881 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 999378001882 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 999378001883 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 999378001884 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 999378001885 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378001886 motif II; other site 999378001887 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 999378001888 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 999378001889 active site 999378001890 metal binding site [ion binding]; metal-binding site 999378001891 DNA binding site [nucleotide binding] 999378001892 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 999378001893 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 999378001894 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 999378001895 Walker A/P-loop; other site 999378001896 ATP binding site [chemical binding]; other site 999378001897 Q-loop/lid; other site 999378001898 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378001899 ABC transporter signature motif; other site 999378001900 Walker B; other site 999378001901 D-loop; other site 999378001902 H-loop/switch region; other site 999378001903 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 999378001904 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 999378001905 putative dimer interface [polypeptide binding]; other site 999378001906 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 999378001907 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 999378001908 minor groove reading motif; other site 999378001909 helix-hairpin-helix signature motif; other site 999378001910 substrate binding pocket [chemical binding]; other site 999378001911 active site 999378001912 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 999378001913 DNA binding and oxoG recognition site [nucleotide binding] 999378001914 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 999378001915 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 999378001916 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 999378001917 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 999378001918 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 999378001919 dimer interface [polypeptide binding]; other site 999378001920 substrate binding site [chemical binding]; other site 999378001921 ATP binding site [chemical binding]; other site 999378001922 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 999378001923 NADH(P)-binding; Region: NAD_binding_10; pfam13460 999378001924 NAD binding site [chemical binding]; other site 999378001925 substrate binding site [chemical binding]; other site 999378001926 putative active site [active] 999378001927 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 999378001928 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 999378001929 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 999378001930 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 999378001931 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 999378001932 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 999378001933 zinc binding site [ion binding]; other site 999378001934 putative ligand binding site [chemical binding]; other site 999378001935 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 999378001936 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 999378001937 zinc binding site [ion binding]; other site 999378001938 putative ligand binding site [chemical binding]; other site 999378001939 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 999378001940 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 999378001941 TM-ABC transporter signature motif; other site 999378001942 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 999378001943 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378001944 Walker A/P-loop; other site 999378001945 ATP binding site [chemical binding]; other site 999378001946 Q-loop/lid; other site 999378001947 ABC transporter signature motif; other site 999378001948 Walker B; other site 999378001949 D-loop; other site 999378001950 H-loop/switch region; other site 999378001951 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 999378001952 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 999378001953 NADP binding site [chemical binding]; other site 999378001954 dimer interface [polypeptide binding]; other site 999378001955 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 999378001956 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 999378001957 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 999378001958 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 999378001959 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378001960 motif II; other site 999378001961 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 999378001962 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 999378001963 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 999378001964 Ligand binding site; other site 999378001965 Putative Catalytic site; other site 999378001966 DXD motif; other site 999378001967 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 999378001968 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 999378001969 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 999378001970 Predicted membrane protein [Function unknown]; Region: COG2246 999378001971 GtrA-like protein; Region: GtrA; pfam04138 999378001972 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 999378001973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999378001974 active site 999378001975 phosphorylation site [posttranslational modification] 999378001976 intermolecular recognition site; other site 999378001977 dimerization interface [polypeptide binding]; other site 999378001978 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 999378001979 DNA binding site [nucleotide binding] 999378001980 Di-sulfide bridge nucleocytoplasmic transport domain; Region: Brr6_like_C_C; cl12377 999378001981 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 999378001982 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 999378001983 dimer interface [polypeptide binding]; other site 999378001984 phosphorylation site [posttranslational modification] 999378001985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999378001986 ATP binding site [chemical binding]; other site 999378001987 Mg2+ binding site [ion binding]; other site 999378001988 G-X-G motif; other site 999378001989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 999378001990 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 999378001991 hypothetical protein; Provisional; Region: PRK06194 999378001992 classical (c) SDRs; Region: SDR_c; cd05233 999378001993 NAD(P) binding site [chemical binding]; other site 999378001994 active site 999378001995 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 999378001996 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 999378001997 dimer interface [polypeptide binding]; other site 999378001998 FMN binding site [chemical binding]; other site 999378001999 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 999378002000 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 999378002001 phosphate binding site [ion binding]; other site 999378002002 Predicted transcriptional regulators [Transcription]; Region: COG1695 999378002003 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 999378002004 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 999378002005 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 999378002006 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 999378002007 putative NAD(P) binding site [chemical binding]; other site 999378002008 dimer interface [polypeptide binding]; other site 999378002009 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 999378002010 Domain of unknown function DUF20; Region: UPF0118; pfam01594 999378002011 LexA repressor; Validated; Region: PRK00215 999378002012 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 999378002013 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 999378002014 Catalytic site [active] 999378002015 Membrane transport protein; Region: Mem_trans; pfam03547 999378002016 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 999378002017 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 999378002018 Uncharacterized conserved protein [Function unknown]; Region: COG3189 999378002019 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 999378002020 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 999378002021 Cl binding site [ion binding]; other site 999378002022 oligomer interface [polypeptide binding]; other site 999378002023 Transcriptional regulator [Transcription]; Region: LysR; COG0583 999378002024 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 999378002025 The substrate binding domain of LysR-type transcriptional regulator MleR which required for malolactic fermentation, contains type 2 periplasmic binidning fold; Region: PBP2_MleR; cd08437 999378002026 putative dimerization interface [polypeptide binding]; other site 999378002027 malate dehydrogenase; Provisional; Region: PRK13529 999378002028 Malic enzyme, N-terminal domain; Region: malic; pfam00390 999378002029 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 999378002030 NAD(P) binding site [chemical binding]; other site 999378002031 Membrane transport protein; Region: Mem_trans; pfam03547 999378002032 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 999378002033 dimer interface [polypeptide binding]; other site 999378002034 catalytic triad [active] 999378002035 peroxidatic and resolving cysteines [active] 999378002036 Flavodoxin domain; Region: Flavodoxin_5; cl17428 999378002037 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999378002038 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999378002039 non-specific DNA binding site [nucleotide binding]; other site 999378002040 salt bridge; other site 999378002041 sequence-specific DNA binding site [nucleotide binding]; other site 999378002042 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 999378002043 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 999378002044 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999378002045 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 999378002046 Walker A/P-loop; other site 999378002047 ATP binding site [chemical binding]; other site 999378002048 Q-loop/lid; other site 999378002049 ABC transporter signature motif; other site 999378002050 Walker B; other site 999378002051 D-loop; other site 999378002052 H-loop/switch region; other site 999378002053 oligoendopeptidase F; Region: pepF; TIGR00181 999378002054 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 999378002055 active site 999378002056 Zn binding site [ion binding]; other site 999378002057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 999378002058 glucose-1-dehydrogenase; Provisional; Region: PRK06947 999378002059 NAD(P) binding site [chemical binding]; other site 999378002060 active site 999378002061 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 999378002062 active site 999378002063 multimer interface [polypeptide binding]; other site 999378002064 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 999378002065 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 999378002066 Soluble P-type ATPase [General function prediction only]; Region: COG4087 999378002067 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 999378002068 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 999378002069 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 999378002070 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 999378002071 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 999378002072 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378002073 motif II; other site 999378002074 Transcriptional regulators [Transcription]; Region: MarR; COG1846 999378002075 MarR family; Region: MarR_2; pfam12802 999378002076 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 999378002077 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 999378002078 flavoprotein NrdI; Provisional; Region: PRK02551 999378002079 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 999378002080 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 999378002081 active site 999378002082 catalytic tetrad [active] 999378002083 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 999378002084 Predicted membrane protein [Function unknown]; Region: COG2323 999378002085 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 999378002086 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 999378002087 substrate binding site [chemical binding]; other site 999378002088 THF binding site; other site 999378002089 zinc-binding site [ion binding]; other site 999378002090 S-ribosylhomocysteinase; Provisional; Region: PRK02260 999378002091 Uncharacterized conserved protein [Function unknown]; Region: COG0398 999378002092 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 999378002093 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 999378002094 RuvA N terminal domain; Region: RuvA_N; pfam01330 999378002095 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 999378002096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999378002097 Walker A motif; other site 999378002098 ATP binding site [chemical binding]; other site 999378002099 Walker B motif; other site 999378002100 arginine finger; other site 999378002101 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 999378002102 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 999378002103 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 999378002104 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 999378002105 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 999378002106 Preprotein translocase subunit; Region: YajC; pfam02699 999378002107 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 999378002108 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 999378002109 putative catalytic cysteine [active] 999378002110 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 999378002111 putative active site [active] 999378002112 metal binding site [ion binding]; metal-binding site 999378002113 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 999378002114 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 999378002115 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 999378002116 FeoA domain; Region: FeoA; pfam04023 999378002117 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 999378002118 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 999378002119 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 999378002120 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 999378002121 active site 999378002122 DNA polymerase IV; Validated; Region: PRK02406 999378002123 DNA binding site [nucleotide binding] 999378002124 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 999378002125 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999378002126 DNA-binding site [nucleotide binding]; DNA binding site 999378002127 DRTGG domain; Region: DRTGG; pfam07085 999378002128 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 999378002129 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 999378002130 DHH family; Region: DHH; pfam01368 999378002131 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 999378002132 DEAD-like helicases superfamily; Region: DEXDc; smart00487 999378002133 ATP binding site [chemical binding]; other site 999378002134 Mg++ binding site [ion binding]; other site 999378002135 motif III; other site 999378002136 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 999378002137 nucleotide binding region [chemical binding]; other site 999378002138 ATP-binding site [chemical binding]; other site 999378002139 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 999378002140 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 999378002141 motif 1; other site 999378002142 active site 999378002143 motif 2; other site 999378002144 motif 3; other site 999378002145 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 999378002146 DHHA1 domain; Region: DHHA1; pfam02272 999378002147 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 999378002148 hypothetical protein; Provisional; Region: PRK05473 999378002149 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 999378002150 hypothetical protein; Provisional; Region: PRK13678 999378002151 Cell division protein ZapA; Region: ZapA; pfam05164 999378002152 Colicin V production protein; Region: Colicin_V; pfam02674 999378002153 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 999378002154 MutS domain III; Region: MutS_III; pfam05192 999378002155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378002156 Walker A/P-loop; other site 999378002157 ATP binding site [chemical binding]; other site 999378002158 Q-loop/lid; other site 999378002159 ABC transporter signature motif; other site 999378002160 Walker B; other site 999378002161 D-loop; other site 999378002162 H-loop/switch region; other site 999378002163 V-type ATP synthase subunit H; Validated; Region: PRK06397 999378002164 Smr domain; Region: Smr; pfam01713 999378002165 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 999378002166 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 999378002167 catalytic residues [active] 999378002168 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 999378002169 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 999378002170 acyl-activating enzyme (AAE) consensus motif; other site 999378002171 AMP binding site [chemical binding]; other site 999378002172 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 999378002173 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 999378002174 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 999378002175 DltD N-terminal region; Region: DltD_N; pfam04915 999378002176 DltD central region; Region: DltD_M; pfam04918 999378002177 DltD C-terminal region; Region: DltD_C; pfam04914 999378002178 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 999378002179 glutamate racemase; Provisional; Region: PRK00865 999378002180 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 999378002181 active site 999378002182 dimerization interface [polypeptide binding]; other site 999378002183 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 999378002184 active site 999378002185 metal binding site [ion binding]; metal-binding site 999378002186 homotetramer interface [polypeptide binding]; other site 999378002187 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 999378002188 amphipathic channel; other site 999378002189 Asn-Pro-Ala signature motifs; other site 999378002190 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 999378002191 FOG: CBS domain [General function prediction only]; Region: COG0517 999378002192 Domain of unknown function (DUF368); Region: DUF368; pfam04018 999378002193 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 999378002194 Mechanosensitive ion channel; Region: MS_channel; pfam00924 999378002195 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 999378002196 YtxH-like protein; Region: YtxH; pfam12732 999378002197 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 999378002198 HTH domain; Region: HTH_11; pfam08279 999378002199 3H domain; Region: 3H; pfam02829 999378002200 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 999378002201 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 999378002202 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 999378002203 active site 999378002204 catabolite control protein A; Region: ccpA; TIGR01481 999378002205 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 999378002206 DNA binding site [nucleotide binding] 999378002207 domain linker motif; other site 999378002208 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 999378002209 dimerization interface [polypeptide binding]; other site 999378002210 effector binding site; other site 999378002211 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 999378002212 Helix-turn-helix domain; Region: HTH_38; pfam13936 999378002213 Homeodomain-like domain; Region: HTH_32; pfam13565 999378002214 Integrase core domain; Region: rve; pfam00665 999378002215 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 999378002216 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 999378002217 Transglycosylase; Region: Transgly; pfam00912 999378002218 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 999378002219 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 999378002220 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378002221 motif II; other site 999378002222 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 999378002223 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 999378002224 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 999378002225 dipeptidase PepV; Reviewed; Region: PRK07318 999378002226 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 999378002227 active site 999378002228 metal binding site [ion binding]; metal-binding site 999378002229 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 999378002230 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 999378002231 active site 999378002232 catalytic site [active] 999378002233 metal binding site [ion binding]; metal-binding site 999378002234 YibE/F-like protein; Region: YibE_F; pfam07907 999378002235 YibE/F-like protein; Region: YibE_F; pfam07907 999378002236 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 999378002237 putative active site [active] 999378002238 putative metal binding site [ion binding]; other site 999378002239 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 999378002240 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 999378002241 active site 999378002242 metal binding site [ion binding]; metal-binding site 999378002243 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 999378002244 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 999378002245 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 999378002246 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378002247 active site 999378002248 motif I; other site 999378002249 motif II; other site 999378002250 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378002251 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 999378002252 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 999378002253 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 999378002254 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 999378002255 tetramer interfaces [polypeptide binding]; other site 999378002256 binuclear metal-binding site [ion binding]; other site 999378002257 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 999378002258 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 999378002259 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 999378002260 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 999378002261 active site 999378002262 general stress protein 13; Validated; Region: PRK08059 999378002263 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 999378002264 RNA binding site [nucleotide binding]; other site 999378002265 Domain of unknown function (DUF4323); Region: DUF4323; pfam14211 999378002266 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 999378002267 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 999378002268 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 999378002269 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 999378002270 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 999378002271 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 999378002272 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 999378002273 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 999378002274 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 999378002275 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 999378002276 putative ADP-binding pocket [chemical binding]; other site 999378002277 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 999378002278 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 999378002279 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 999378002280 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 999378002281 aromatic amino acid aminotransferase; Validated; Region: PRK07309 999378002282 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 999378002283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999378002284 homodimer interface [polypeptide binding]; other site 999378002285 catalytic residue [active] 999378002286 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 999378002287 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 999378002288 Sulfatase; Region: Sulfatase; pfam00884 999378002289 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 999378002290 metal binding site 2 [ion binding]; metal-binding site 999378002291 putative DNA binding helix; other site 999378002292 metal binding site 1 [ion binding]; metal-binding site 999378002293 dimer interface [polypeptide binding]; other site 999378002294 structural Zn2+ binding site [ion binding]; other site 999378002295 Domain of unknown function (DUF4323); Region: DUF4323; pfam14211 999378002296 S-adenosylmethionine synthetase; Validated; Region: PRK05250 999378002297 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 999378002298 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 999378002299 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 999378002300 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 999378002301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378002302 putative substrate translocation pore; other site 999378002303 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 999378002304 DNA binding residues [nucleotide binding] 999378002305 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 999378002306 putative dimer interface [polypeptide binding]; other site 999378002307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378002308 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 999378002309 putative substrate translocation pore; other site 999378002310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378002311 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 999378002312 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 999378002313 active site 999378002314 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 999378002315 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 999378002316 HIGH motif; other site 999378002317 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 999378002318 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 999378002319 active site 999378002320 KMSKS motif; other site 999378002321 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 999378002322 tRNA binding surface [nucleotide binding]; other site 999378002323 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 999378002324 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 999378002325 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 999378002326 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 999378002327 RNA binding surface [nucleotide binding]; other site 999378002328 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 999378002329 active site 999378002330 uracil binding [chemical binding]; other site 999378002331 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 999378002332 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 999378002333 putative substrate binding site [chemical binding]; other site 999378002334 putative ATP binding site [chemical binding]; other site 999378002335 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 999378002336 nudix motif; other site 999378002337 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 999378002338 Int/Topo IB signature motif; other site 999378002339 Abi-like protein; Region: Abi_2; pfam07751 999378002340 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 999378002341 Domain of unknown function (DUF955); Region: DUF955; pfam06114 999378002342 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999378002343 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999378002344 non-specific DNA binding site [nucleotide binding]; other site 999378002345 salt bridge; other site 999378002346 sequence-specific DNA binding site [nucleotide binding]; other site 999378002347 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 999378002348 Domain of unknown function (DUF771); Region: DUF771; cl09962 999378002349 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 999378002350 RecT family; Region: RecT; cl04285 999378002351 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999378002352 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999378002353 non-specific DNA binding site [nucleotide binding]; other site 999378002354 salt bridge; other site 999378002355 sequence-specific DNA binding site [nucleotide binding]; other site 999378002356 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 999378002357 DNA-binding site [nucleotide binding]; DNA binding site 999378002358 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 999378002359 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 999378002360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999378002361 Walker A motif; other site 999378002362 ATP binding site [chemical binding]; other site 999378002363 Walker B motif; other site 999378002364 HNH endonuclease; Region: HNH_3; pfam13392 999378002365 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 999378002366 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 999378002367 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 999378002368 DNA binding residues [nucleotide binding] 999378002369 HNH endonuclease; Region: HNH; pfam01844 999378002370 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 999378002371 Phage-related protein [Function unknown]; Region: COG4695; cl01923 999378002372 Phage portal protein; Region: Phage_portal; pfam04860 999378002373 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 999378002374 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 999378002375 oligomer interface [polypeptide binding]; other site 999378002376 active site residues [active] 999378002377 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 999378002378 Phage capsid family; Region: Phage_capsid; pfam05065 999378002379 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 999378002380 oligomerization interface [polypeptide binding]; other site 999378002381 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 999378002382 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 999378002383 Tropomyosin like; Region: Tropomyosin_1; pfam12718 999378002384 tape measure domain; Region: tape_meas_nterm; TIGR02675 999378002385 Phage-related protein [Function unknown]; Region: COG5412 999378002386 Phage-related protein [Function unknown]; Region: COG4722 999378002387 Phage tail protein; Region: Sipho_tail; cl17486 999378002388 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 999378002389 Protein of unknown function (DUF1617); Region: DUF1617; pfam07761 999378002390 Bacteriophage holin; Region: Phage_holin_1; pfam04531 999378002391 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 999378002392 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 999378002393 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 999378002394 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 999378002395 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 999378002396 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 999378002397 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 999378002398 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 999378002399 catalytic residues [active] 999378002400 dimer interface [polypeptide binding]; other site 999378002401 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 999378002402 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 999378002403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999378002404 homodimer interface [polypeptide binding]; other site 999378002405 catalytic residue [active] 999378002406 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 999378002407 Helix-turn-helix domain; Region: HTH_38; pfam13936 999378002408 Integrase core domain; Region: rve; pfam00665 999378002409 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 999378002410 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 999378002411 active site 999378002412 metal binding site [ion binding]; metal-binding site 999378002413 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 999378002414 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 999378002415 Competence protein CoiA-like family; Region: CoiA; cl11541 999378002416 Thioredoxin; Region: Thioredoxin_5; pfam13743 999378002417 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 999378002418 putative active site [active] 999378002419 putative metal binding residues [ion binding]; other site 999378002420 signature motif; other site 999378002421 putative triphosphate binding site [ion binding]; other site 999378002422 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 999378002423 synthetase active site [active] 999378002424 NTP binding site [chemical binding]; other site 999378002425 metal binding site [ion binding]; metal-binding site 999378002426 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 999378002427 ATP-NAD kinase; Region: NAD_kinase; pfam01513 999378002428 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 999378002429 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 999378002430 RNA binding surface [nucleotide binding]; other site 999378002431 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 999378002432 active site 999378002433 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 999378002434 ApbE family; Region: ApbE; pfam02424 999378002435 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 999378002436 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 999378002437 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 999378002438 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 999378002439 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 999378002440 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 999378002441 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 999378002442 active site 999378002443 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 999378002444 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 999378002445 Cl binding site [ion binding]; other site 999378002446 oligomer interface [polypeptide binding]; other site 999378002447 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 999378002448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999378002449 S-adenosylmethionine binding site [chemical binding]; other site 999378002450 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 999378002451 Protein of unknown function (DUF1149); Region: DUF1149; pfam06619 999378002452 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 999378002453 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 999378002454 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 999378002455 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 999378002456 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 999378002457 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 999378002458 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 999378002459 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 999378002460 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 999378002461 classical (c) SDRs; Region: SDR_c; cd05233 999378002462 NAD(P) binding site [chemical binding]; other site 999378002463 active site 999378002464 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 999378002465 Helix-turn-helix domain; Region: HTH_25; pfam13413 999378002466 non-specific DNA binding site [nucleotide binding]; other site 999378002467 salt bridge; other site 999378002468 sequence-specific DNA binding site [nucleotide binding]; other site 999378002469 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 999378002470 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 999378002471 competence damage-inducible protein A; Provisional; Region: PRK00549 999378002472 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 999378002473 putative MPT binding site; other site 999378002474 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 999378002475 recombinase A; Provisional; Region: recA; PRK09354 999378002476 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 999378002477 hexamer interface [polypeptide binding]; other site 999378002478 Walker A motif; other site 999378002479 ATP binding site [chemical binding]; other site 999378002480 Walker B motif; other site 999378002481 ribonuclease Y; Region: RNase_Y; TIGR03319 999378002482 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 999378002483 Zn2+ binding site [ion binding]; other site 999378002484 Mg2+ binding site [ion binding]; other site 999378002485 Uncharacterized conserved protein [Function unknown]; Region: COG1739 999378002486 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 999378002487 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 999378002488 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 999378002489 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 999378002490 ATP binding site [chemical binding]; other site 999378002491 putative Mg++ binding site [ion binding]; other site 999378002492 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 999378002493 nucleotide binding region [chemical binding]; other site 999378002494 ATP-binding site [chemical binding]; other site 999378002495 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 999378002496 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 999378002497 active site 999378002498 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 999378002499 30S subunit binding site; other site 999378002500 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 999378002501 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 999378002502 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 999378002503 nucleotide binding region [chemical binding]; other site 999378002504 ATP-binding site [chemical binding]; other site 999378002505 peptide chain release factor 2; Validated; Region: prfB; PRK00578 999378002506 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 999378002507 PCRF domain; Region: PCRF; pfam03462 999378002508 RF-1 domain; Region: RF-1; pfam00472 999378002509 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 999378002510 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378002511 Walker A/P-loop; other site 999378002512 ATP binding site [chemical binding]; other site 999378002513 Q-loop/lid; other site 999378002514 ABC transporter signature motif; other site 999378002515 Walker B; other site 999378002516 D-loop; other site 999378002517 H-loop/switch region; other site 999378002518 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 999378002519 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 999378002520 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 999378002521 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 999378002522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999378002523 active site 999378002524 phosphorylation site [posttranslational modification] 999378002525 intermolecular recognition site; other site 999378002526 dimerization interface [polypeptide binding]; other site 999378002527 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 999378002528 DNA binding site [nucleotide binding] 999378002529 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 999378002530 PAS domain; Region: PAS_8; pfam13188 999378002531 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 999378002532 dimer interface [polypeptide binding]; other site 999378002533 phosphorylation site [posttranslational modification] 999378002534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999378002535 ATP binding site [chemical binding]; other site 999378002536 Mg2+ binding site [ion binding]; other site 999378002537 G-X-G motif; other site 999378002538 phosphate binding protein; Region: ptsS_2; TIGR02136 999378002539 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 999378002540 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 999378002541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378002542 dimer interface [polypeptide binding]; other site 999378002543 conserved gate region; other site 999378002544 putative PBP binding loops; other site 999378002545 ABC-ATPase subunit interface; other site 999378002546 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 999378002547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378002548 dimer interface [polypeptide binding]; other site 999378002549 conserved gate region; other site 999378002550 putative PBP binding loops; other site 999378002551 ABC-ATPase subunit interface; other site 999378002552 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 999378002553 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 999378002554 Walker A/P-loop; other site 999378002555 ATP binding site [chemical binding]; other site 999378002556 Q-loop/lid; other site 999378002557 ABC transporter signature motif; other site 999378002558 Walker B; other site 999378002559 D-loop; other site 999378002560 H-loop/switch region; other site 999378002561 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14255 999378002562 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 999378002563 Walker A/P-loop; other site 999378002564 ATP binding site [chemical binding]; other site 999378002565 Q-loop/lid; other site 999378002566 ABC transporter signature motif; other site 999378002567 Walker B; other site 999378002568 D-loop; other site 999378002569 H-loop/switch region; other site 999378002570 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 999378002571 PhoU domain; Region: PhoU; pfam01895 999378002572 PhoU domain; Region: PhoU; pfam01895 999378002573 Uncharacterized conserved protein [Function unknown]; Region: COG3595 999378002574 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 999378002575 Membrane protein of unknown function; Region: DUF360; pfam04020 999378002576 HPr kinase/phosphorylase; Provisional; Region: PRK05428 999378002577 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 999378002578 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 999378002579 Hpr binding site; other site 999378002580 active site 999378002581 homohexamer subunit interaction site [polypeptide binding]; other site 999378002582 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 999378002583 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 999378002584 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 999378002585 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 999378002586 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 999378002587 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 999378002588 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 999378002589 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 999378002590 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 999378002591 active site 999378002592 substrate binding site [chemical binding]; other site 999378002593 metal binding site [ion binding]; metal-binding site 999378002594 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 999378002595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999378002596 active site 999378002597 phosphorylation site [posttranslational modification] 999378002598 intermolecular recognition site; other site 999378002599 dimerization interface [polypeptide binding]; other site 999378002600 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 999378002601 DNA binding site [nucleotide binding] 999378002602 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 999378002603 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 999378002604 dimer interface [polypeptide binding]; other site 999378002605 phosphorylation site [posttranslational modification] 999378002606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999378002607 ATP binding site [chemical binding]; other site 999378002608 Mg2+ binding site [ion binding]; other site 999378002609 G-X-G motif; other site 999378002610 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378002611 Walker A/P-loop; other site 999378002612 ATP binding site [chemical binding]; other site 999378002613 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 999378002614 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 999378002615 Q-loop/lid; other site 999378002616 ABC transporter signature motif; other site 999378002617 Walker B; other site 999378002618 D-loop; other site 999378002619 H-loop/switch region; other site 999378002620 FtsX-like permease family; Region: FtsX; pfam02687 999378002621 HD domain; Region: HD_3; cl17350 999378002622 excinuclease ABC subunit B; Provisional; Region: PRK05298 999378002623 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 999378002624 ATP binding site [chemical binding]; other site 999378002625 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 999378002626 nucleotide binding region [chemical binding]; other site 999378002627 ATP-binding site [chemical binding]; other site 999378002628 Ultra-violet resistance protein B; Region: UvrB; pfam12344 999378002629 UvrB/uvrC motif; Region: UVR; pfam02151 999378002630 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 999378002631 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 999378002632 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 999378002633 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 999378002634 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 999378002635 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 999378002636 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 999378002637 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 999378002638 phosphate binding site [ion binding]; other site 999378002639 putative substrate binding pocket [chemical binding]; other site 999378002640 dimer interface [polypeptide binding]; other site 999378002641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 999378002642 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 999378002643 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 999378002644 MarR family; Region: MarR; pfam01047 999378002645 Clp protease; Region: CLP_protease; pfam00574 999378002646 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 999378002647 oligomer interface [polypeptide binding]; other site 999378002648 active site residues [active] 999378002649 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 999378002650 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 999378002651 Int/Topo IB signature motif; other site 999378002652 Ion transport protein; Region: Ion_trans; pfam00520 999378002653 Ion channel; Region: Ion_trans_2; pfam07885 999378002654 Short C-terminal domain; Region: SHOCT; pfam09851 999378002655 Domain of unknown function (DUF955); Region: DUF955; cl01076 999378002656 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999378002657 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999378002658 non-specific DNA binding site [nucleotide binding]; other site 999378002659 salt bridge; other site 999378002660 sequence-specific DNA binding site [nucleotide binding]; other site 999378002661 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 999378002662 sequence-specific DNA binding site [nucleotide binding]; other site 999378002663 salt bridge; other site 999378002664 ORF6N domain; Region: ORF6N; pfam10543 999378002665 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 999378002666 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 999378002667 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 999378002668 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 999378002669 ATP binding site [chemical binding]; other site 999378002670 putative Mg++ binding site [ion binding]; other site 999378002671 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 999378002672 nucleotide binding region [chemical binding]; other site 999378002673 ATP-binding site [chemical binding]; other site 999378002674 AAA domain; Region: AAA_24; pfam13479 999378002675 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 999378002676 polymerase nucleotide-binding site; other site 999378002677 DNA-binding residues [nucleotide binding]; DNA binding site 999378002678 nucleotide binding site [chemical binding]; other site 999378002679 primase nucleotide-binding site [nucleotide binding]; other site 999378002680 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 999378002681 Virulence-associated protein E; Region: VirE; pfam05272 999378002682 VRR-NUC domain; Region: VRR_NUC; pfam08774 999378002683 HNH endonuclease; Region: HNH_3; pfam13392 999378002684 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 999378002685 HNH endonuclease; Region: HNH; pfam01844 999378002686 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 999378002687 Phage-related protein [Function unknown]; Region: COG4695; cl01923 999378002688 Phage portal protein; Region: Phage_portal; pfam04860 999378002689 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 999378002690 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 999378002691 oligomer interface [polypeptide binding]; other site 999378002692 active site residues [active] 999378002693 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 999378002694 Phage capsid family; Region: Phage_capsid; pfam05065 999378002695 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 999378002696 oligomerization interface [polypeptide binding]; other site 999378002697 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 999378002698 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 999378002699 Phage-related minor tail protein [Function unknown]; Region: COG5280 999378002700 Phage-related protein [Function unknown]; Region: COG5412 999378002701 Phage-related protein [Function unknown]; Region: COG4722 999378002702 Phage tail protein; Region: Sipho_tail; cl17486 999378002703 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 999378002704 Protein of unknown function (DUF1617); Region: DUF1617; pfam07761 999378002705 Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890 999378002706 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 999378002707 amidase catalytic site [active] 999378002708 Zn binding residues [ion binding]; other site 999378002709 substrate binding site [chemical binding]; other site 999378002710 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 999378002711 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 999378002712 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 999378002713 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 999378002714 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 999378002715 Phosphoglycerate kinase; Region: PGK; pfam00162 999378002716 substrate binding site [chemical binding]; other site 999378002717 hinge regions; other site 999378002718 ADP binding site [chemical binding]; other site 999378002719 catalytic site [active] 999378002720 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 999378002721 triosephosphate isomerase; Provisional; Region: PRK14567 999378002722 substrate binding site [chemical binding]; other site 999378002723 dimer interface [polypeptide binding]; other site 999378002724 catalytic triad [active] 999378002725 enolase; Provisional; Region: eno; PRK00077 999378002726 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 999378002727 dimer interface [polypeptide binding]; other site 999378002728 metal binding site [ion binding]; metal-binding site 999378002729 substrate binding pocket [chemical binding]; other site 999378002730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378002731 H+ Antiporter protein; Region: 2A0121; TIGR00900 999378002732 putative substrate translocation pore; other site 999378002733 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 999378002734 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 999378002735 Cl- selectivity filter; other site 999378002736 Cl- binding residues [ion binding]; other site 999378002737 pore gating glutamate residue; other site 999378002738 dimer interface [polypeptide binding]; other site 999378002739 H+/Cl- coupling transport residue; other site 999378002740 TrkA-C domain; Region: TrkA_C; pfam02080 999378002741 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 999378002742 Esterase/lipase [General function prediction only]; Region: COG1647 999378002743 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 999378002744 ribonuclease R; Region: RNase_R; TIGR02063 999378002745 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 999378002746 RNB domain; Region: RNB; pfam00773 999378002747 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 999378002748 RNA binding site [nucleotide binding]; other site 999378002749 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 999378002750 SmpB-tmRNA interface; other site 999378002751 Transcriptional regulators [Transcription]; Region: PurR; COG1609 999378002752 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 999378002753 DNA binding site [nucleotide binding] 999378002754 domain linker motif; other site 999378002755 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 999378002756 ligand binding site [chemical binding]; other site 999378002757 dimerization interface [polypeptide binding]; other site 999378002758 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 999378002759 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 999378002760 Ca binding site [ion binding]; other site 999378002761 active site 999378002762 catalytic site [active] 999378002763 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 999378002764 homodimer interface [polypeptide binding]; other site 999378002765 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 999378002766 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 999378002767 active site 999378002768 homodimer interface [polypeptide binding]; other site 999378002769 catalytic site [active] 999378002770 maltose phosphorylase; Provisional; Region: PRK13807 999378002771 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 999378002772 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 999378002773 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 999378002774 beta-phosphoglucomutase; Region: bPGM; TIGR01990 999378002775 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378002776 motif II; other site 999378002777 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 999378002778 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 999378002779 Walker A/P-loop; other site 999378002780 ATP binding site [chemical binding]; other site 999378002781 Q-loop/lid; other site 999378002782 ABC transporter signature motif; other site 999378002783 Walker B; other site 999378002784 D-loop; other site 999378002785 H-loop/switch region; other site 999378002786 TOBE domain; Region: TOBE_2; pfam08402 999378002787 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 999378002788 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 999378002789 Ca binding site [ion binding]; other site 999378002790 active site 999378002791 catalytic site [active] 999378002792 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 999378002793 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 999378002794 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 999378002795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378002796 dimer interface [polypeptide binding]; other site 999378002797 conserved gate region; other site 999378002798 putative PBP binding loops; other site 999378002799 ABC-ATPase subunit interface; other site 999378002800 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 999378002801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378002802 dimer interface [polypeptide binding]; other site 999378002803 conserved gate region; other site 999378002804 ABC-ATPase subunit interface; other site 999378002805 ATP synthase regulation protein NCA2; Region: NCA2; pfam08637 999378002806 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999378002807 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999378002808 non-specific DNA binding site [nucleotide binding]; other site 999378002809 salt bridge; other site 999378002810 sequence-specific DNA binding site [nucleotide binding]; other site 999378002811 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 999378002812 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 999378002813 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 999378002814 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 999378002815 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 999378002816 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 999378002817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378002818 dimer interface [polypeptide binding]; other site 999378002819 conserved gate region; other site 999378002820 putative PBP binding loops; other site 999378002821 ABC-ATPase subunit interface; other site 999378002822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378002823 dimer interface [polypeptide binding]; other site 999378002824 conserved gate region; other site 999378002825 putative PBP binding loops; other site 999378002826 ABC-ATPase subunit interface; other site 999378002827 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 999378002828 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378002829 Walker A/P-loop; other site 999378002830 ATP binding site [chemical binding]; other site 999378002831 Q-loop/lid; other site 999378002832 ABC transporter signature motif; other site 999378002833 Walker B; other site 999378002834 D-loop; other site 999378002835 H-loop/switch region; other site 999378002836 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999378002837 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 999378002838 Coenzyme A binding pocket [chemical binding]; other site 999378002839 Tubby C 2; Region: Tub_2; cl02043 999378002840 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378002841 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 999378002842 active site 999378002843 motif I; other site 999378002844 motif II; other site 999378002845 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 999378002846 ligand binding site [chemical binding]; other site 999378002847 active site 999378002848 UGI interface [polypeptide binding]; other site 999378002849 catalytic site [active] 999378002850 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 999378002851 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 999378002852 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 999378002853 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378002854 Walker A/P-loop; other site 999378002855 ATP binding site [chemical binding]; other site 999378002856 Q-loop/lid; other site 999378002857 ABC transporter signature motif; other site 999378002858 Walker B; other site 999378002859 D-loop; other site 999378002860 H-loop/switch region; other site 999378002861 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 999378002862 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 999378002863 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 999378002864 active site 999378002865 catalytic site [active] 999378002866 substrate binding site [chemical binding]; other site 999378002867 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 999378002868 active site 999378002869 putative catalytic site [active] 999378002870 DNA binding site [nucleotide binding] 999378002871 putative phosphate binding site [ion binding]; other site 999378002872 metal binding site A [ion binding]; metal-binding site 999378002873 AP binding site [nucleotide binding]; other site 999378002874 metal binding site B [ion binding]; metal-binding site 999378002875 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 999378002876 FAD binding domain; Region: FAD_binding_4; pfam01565 999378002877 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 999378002878 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 999378002879 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 999378002880 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999378002881 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999378002882 non-specific DNA binding site [nucleotide binding]; other site 999378002883 salt bridge; other site 999378002884 sequence-specific DNA binding site [nucleotide binding]; other site 999378002885 Cupin domain; Region: Cupin_2; pfam07883 999378002886 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 999378002887 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 999378002888 Walker A/P-loop; other site 999378002889 ATP binding site [chemical binding]; other site 999378002890 Q-loop/lid; other site 999378002891 ABC transporter signature motif; other site 999378002892 Walker B; other site 999378002893 D-loop; other site 999378002894 H-loop/switch region; other site 999378002895 TOBE domain; Region: TOBE_2; pfam08402 999378002896 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 999378002897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378002898 dimer interface [polypeptide binding]; other site 999378002899 conserved gate region; other site 999378002900 putative PBP binding loops; other site 999378002901 ABC-ATPase subunit interface; other site 999378002902 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 999378002903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378002904 dimer interface [polypeptide binding]; other site 999378002905 conserved gate region; other site 999378002906 putative PBP binding loops; other site 999378002907 ABC-ATPase subunit interface; other site 999378002908 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 999378002909 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 999378002910 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 999378002911 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 999378002912 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 999378002913 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 999378002914 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378002915 motif II; other site 999378002916 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 999378002917 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999378002918 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999378002919 PXA domain; Region: PXA; cl02564 999378002920 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 999378002921 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 999378002922 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 999378002923 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 999378002924 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 999378002925 Walker A/P-loop; other site 999378002926 ATP binding site [chemical binding]; other site 999378002927 Q-loop/lid; other site 999378002928 ABC transporter signature motif; other site 999378002929 Walker B; other site 999378002930 D-loop; other site 999378002931 H-loop/switch region; other site 999378002932 Uncharacterized conserved protein [Function unknown]; Region: COG1624 999378002933 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 999378002934 YbbR-like protein; Region: YbbR; pfam07949 999378002935 YbbR-like protein; Region: YbbR; pfam07949 999378002936 YbbR-like protein; Region: YbbR; pfam07949 999378002937 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 999378002938 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 999378002939 active site 999378002940 substrate binding site [chemical binding]; other site 999378002941 metal binding site [ion binding]; metal-binding site 999378002942 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 999378002943 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 999378002944 glutaminase active site [active] 999378002945 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 999378002946 dimer interface [polypeptide binding]; other site 999378002947 active site 999378002948 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 999378002949 dimer interface [polypeptide binding]; other site 999378002950 active site 999378002951 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 999378002952 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 999378002953 active site 999378002954 Zn binding site [ion binding]; other site 999378002955 hypothetical protein; Validated; Region: PRK00110 999378002956 Type II/IV secretion system protein; Region: T2SE; pfam00437 999378002957 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 999378002958 Walker A motif; other site 999378002959 ATP binding site [chemical binding]; other site 999378002960 Walker B motif; other site 999378002961 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 999378002962 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 999378002963 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 999378002964 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 999378002965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999378002966 S-adenosylmethionine binding site [chemical binding]; other site 999378002967 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 999378002968 Spore germination protein; Region: Spore_permease; cl17796 999378002969 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 999378002970 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 999378002971 putative acyl-acceptor binding pocket; other site 999378002972 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 999378002973 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 999378002974 Ligand binding site; other site 999378002975 metal-binding site 999378002976 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 999378002977 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 999378002978 Ligand binding site; other site 999378002979 metal-binding site 999378002980 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 999378002981 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 999378002982 putative acyl-acceptor binding pocket; other site 999378002983 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 999378002984 Melibiase; Region: Melibiase; pfam02065 999378002985 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 999378002986 SdpI/YhfL protein family; Region: SdpI; pfam13630 999378002987 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 999378002988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999378002989 active site 999378002990 phosphorylation site [posttranslational modification] 999378002991 intermolecular recognition site; other site 999378002992 dimerization interface [polypeptide binding]; other site 999378002993 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 999378002994 DNA binding site [nucleotide binding] 999378002995 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 999378002996 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 999378002997 dimerization interface [polypeptide binding]; other site 999378002998 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 999378002999 dimer interface [polypeptide binding]; other site 999378003000 phosphorylation site [posttranslational modification] 999378003001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999378003002 ATP binding site [chemical binding]; other site 999378003003 Mg2+ binding site [ion binding]; other site 999378003004 G-X-G motif; other site 999378003005 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 999378003006 Predicted acetyltransferase [General function prediction only]; Region: COG3153 999378003007 hypothetical protein; Provisional; Region: PRK04435 999378003008 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 999378003009 DNA-binding interface [nucleotide binding]; DNA binding site 999378003010 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 999378003011 DNA polymerase IV; Reviewed; Region: PRK03103 999378003012 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 999378003013 active site 999378003014 DNA binding site [nucleotide binding] 999378003015 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 999378003016 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 999378003017 Double zinc ribbon; Region: DZR; pfam12773 999378003018 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 999378003019 active site 999378003020 catalytic triad [active] 999378003021 oxyanion hole [active] 999378003022 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 999378003023 Part of AAA domain; Region: AAA_19; pfam13245 999378003024 Family description; Region: UvrD_C_2; pfam13538 999378003025 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 999378003026 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 999378003027 nucleotide binding pocket [chemical binding]; other site 999378003028 K-X-D-G motif; other site 999378003029 catalytic site [active] 999378003030 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 999378003031 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 999378003032 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 999378003033 Dimer interface [polypeptide binding]; other site 999378003034 BRCT sequence motif; other site 999378003035 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 999378003036 putative dimer interface [polypeptide binding]; other site 999378003037 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 999378003038 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 999378003039 putative dimer interface [polypeptide binding]; other site 999378003040 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 999378003041 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 999378003042 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 999378003043 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 999378003044 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 999378003045 GatB domain; Region: GatB_Yqey; smart00845 999378003046 putative lipid kinase; Reviewed; Region: PRK13055 999378003047 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 999378003048 TRAM domain; Region: TRAM; pfam01938 999378003049 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 999378003050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999378003051 S-adenosylmethionine binding site [chemical binding]; other site 999378003052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378003053 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999378003054 putative substrate translocation pore; other site 999378003055 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378003056 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 999378003057 active site 999378003058 motif I; other site 999378003059 motif II; other site 999378003060 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 999378003061 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 999378003062 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 999378003063 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 999378003064 active site 999378003065 Zn binding site [ion binding]; other site 999378003066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378003067 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999378003068 putative substrate translocation pore; other site 999378003069 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999378003070 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 999378003071 Coenzyme A binding pocket [chemical binding]; other site 999378003072 EDD domain protein, DegV family; Region: DegV; TIGR00762 999378003073 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 999378003074 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 999378003075 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 999378003076 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419 999378003077 active site 999378003078 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 999378003079 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 999378003080 formate dehydrogenase; Provisional; Region: PRK07574 999378003081 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 999378003082 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 999378003083 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 999378003084 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 999378003085 ATP binding site [chemical binding]; other site 999378003086 putative Mg++ binding site [ion binding]; other site 999378003087 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 999378003088 nucleotide binding region [chemical binding]; other site 999378003089 ATP-binding site [chemical binding]; other site 999378003090 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 999378003091 active site 999378003092 methionine cluster; other site 999378003093 phosphorylation site [posttranslational modification] 999378003094 metal binding site [ion binding]; metal-binding site 999378003095 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 999378003096 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 999378003097 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 999378003098 ATP binding site [chemical binding]; other site 999378003099 putative Mg++ binding site [ion binding]; other site 999378003100 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 999378003101 nucleotide binding region [chemical binding]; other site 999378003102 ATP-binding site [chemical binding]; other site 999378003103 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 999378003104 HRDC domain; Region: HRDC; pfam00570 999378003105 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 999378003106 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 999378003107 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999378003108 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999378003109 WHG domain; Region: WHG; pfam13305 999378003110 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 999378003111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 999378003112 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 999378003113 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 999378003114 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 999378003115 active site 999378003116 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 999378003117 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 999378003118 active site 999378003119 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 999378003120 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 999378003121 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 999378003122 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 999378003123 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 999378003124 active site 999378003125 tetramer interface; other site 999378003126 putative transposase OrfB; Reviewed; Region: PHA02517 999378003127 HTH-like domain; Region: HTH_21; pfam13276 999378003128 Integrase core domain; Region: rve; pfam00665 999378003129 Integrase core domain; Region: rve_3; pfam13683 999378003130 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 999378003131 Homeodomain-like domain; Region: HTH_23; cl17451 999378003132 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 999378003133 Transposase; Region: HTH_Tnp_1; cl17663 999378003134 Helix-turn-helix domain; Region: HTH_28; pfam13518 999378003135 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 999378003136 active site 999378003137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 999378003138 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 999378003139 NAD(P) binding site [chemical binding]; other site 999378003140 active site 999378003141 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 999378003142 Helix-turn-helix domain; Region: HTH_38; pfam13936 999378003143 Integrase core domain; Region: rve; pfam00665 999378003144 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 999378003145 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 999378003146 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 999378003147 beta-galactosidase; Region: BGL; TIGR03356 999378003148 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 999378003149 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 999378003150 active site turn [active] 999378003151 phosphorylation site [posttranslational modification] 999378003152 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 999378003153 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 999378003154 HPr interaction site; other site 999378003155 glycerol kinase (GK) interaction site [polypeptide binding]; other site 999378003156 active site 999378003157 phosphorylation site [posttranslational modification] 999378003158 transcriptional antiterminator BglG; Provisional; Region: PRK09772 999378003159 CAT RNA binding domain; Region: CAT_RBD; smart01061 999378003160 PRD domain; Region: PRD; pfam00874 999378003161 PRD domain; Region: PRD; pfam00874 999378003162 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 999378003163 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 999378003164 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 999378003165 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 999378003166 Ligand binding site; other site 999378003167 Putative Catalytic site; other site 999378003168 DXD motif; other site 999378003169 Predicted membrane protein [Function unknown]; Region: COG4129 999378003170 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 999378003171 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 999378003172 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 999378003173 DNA-binding site [nucleotide binding]; DNA binding site 999378003174 RNA-binding motif; other site 999378003175 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999378003176 Coenzyme A binding pocket [chemical binding]; other site 999378003177 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 999378003178 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 999378003179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 999378003180 active site 999378003181 xanthine permease; Region: pbuX; TIGR03173 999378003182 ATP-grasp domain; Region: ATP-grasp_4; cl17255 999378003183 adenylosuccinate lyase; Provisional; Region: PRK07492 999378003184 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 999378003185 tetramer interface [polypeptide binding]; other site 999378003186 active site 999378003187 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 999378003188 Sulfatase; Region: Sulfatase; pfam00884 999378003189 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 999378003190 Sugar transport protein; Region: Sugar_transport; pfam06800 999378003191 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 999378003192 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 999378003193 active site 999378003194 dimer interface [polypeptide binding]; other site 999378003195 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 999378003196 dimer interface [polypeptide binding]; other site 999378003197 active site 999378003198 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 999378003199 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 999378003200 Uncharacterized conserved protein [Function unknown]; Region: COG1359 999378003201 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 999378003202 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 999378003203 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 999378003204 Helix-turn-helix domain; Region: HTH_38; pfam13936 999378003205 Integrase core domain; Region: rve; pfam00665 999378003206 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 999378003207 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 999378003208 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 999378003209 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 999378003210 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 999378003211 nucleoside/Zn binding site; other site 999378003212 dimer interface [polypeptide binding]; other site 999378003213 catalytic motif [active] 999378003214 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 999378003215 TspO/MBR family; Region: TspO_MBR; pfam03073 999378003216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378003217 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999378003218 putative substrate translocation pore; other site 999378003219 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 999378003220 Peptidase family C69; Region: Peptidase_C69; pfam03577 999378003221 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 999378003222 catalytic core [active] 999378003223 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 999378003224 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999378003225 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999378003226 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 999378003227 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999378003228 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378003229 Walker A/P-loop; other site 999378003230 ATP binding site [chemical binding]; other site 999378003231 Q-loop/lid; other site 999378003232 ABC transporter signature motif; other site 999378003233 Walker B; other site 999378003234 D-loop; other site 999378003235 H-loop/switch region; other site 999378003236 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 999378003237 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999378003238 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 999378003239 Walker A/P-loop; other site 999378003240 ATP binding site [chemical binding]; other site 999378003241 Q-loop/lid; other site 999378003242 ABC transporter signature motif; other site 999378003243 Walker B; other site 999378003244 D-loop; other site 999378003245 H-loop/switch region; other site 999378003246 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 999378003247 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 999378003248 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 999378003249 putative metal binding site [ion binding]; other site 999378003250 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 999378003251 active site 999378003252 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 999378003253 Beta-lactamase; Region: Beta-lactamase; pfam00144 999378003254 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 999378003255 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 999378003256 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 999378003257 thymidine kinase; Provisional; Region: PRK04296 999378003258 peptide chain release factor 1; Validated; Region: prfA; PRK00591 999378003259 This domain is found in peptide chain release factors; Region: PCRF; smart00937 999378003260 RF-1 domain; Region: RF-1; pfam00472 999378003261 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 999378003262 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999378003263 S-adenosylmethionine binding site [chemical binding]; other site 999378003264 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 999378003265 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 999378003266 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 999378003267 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 999378003268 dimer interface [polypeptide binding]; other site 999378003269 active site 999378003270 glycine-pyridoxal phosphate binding site [chemical binding]; other site 999378003271 folate binding site [chemical binding]; other site 999378003272 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 999378003273 active site 999378003274 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 999378003275 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 999378003276 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 999378003277 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 999378003278 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 999378003279 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 999378003280 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 999378003281 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 999378003282 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 999378003283 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 999378003284 beta subunit interaction interface [polypeptide binding]; other site 999378003285 Walker A motif; other site 999378003286 ATP binding site [chemical binding]; other site 999378003287 Walker B motif; other site 999378003288 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 999378003289 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 999378003290 core domain interface [polypeptide binding]; other site 999378003291 delta subunit interface [polypeptide binding]; other site 999378003292 epsilon subunit interface [polypeptide binding]; other site 999378003293 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 999378003294 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 999378003295 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 999378003296 alpha subunit interaction interface [polypeptide binding]; other site 999378003297 Walker A motif; other site 999378003298 ATP binding site [chemical binding]; other site 999378003299 Walker B motif; other site 999378003300 inhibitor binding site; inhibition site 999378003301 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 999378003302 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 999378003303 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 999378003304 gamma subunit interface [polypeptide binding]; other site 999378003305 epsilon subunit interface [polypeptide binding]; other site 999378003306 LBP interface [polypeptide binding]; other site 999378003307 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 999378003308 rod shape-determining protein MreB; Provisional; Region: PRK13930 999378003309 MreB and similar proteins; Region: MreB_like; cd10225 999378003310 nucleotide binding site [chemical binding]; other site 999378003311 Mg binding site [ion binding]; other site 999378003312 putative protofilament interaction site [polypeptide binding]; other site 999378003313 RodZ interaction site [polypeptide binding]; other site 999378003314 Haemolytic domain; Region: Haemolytic; cl00506 999378003315 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 999378003316 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 999378003317 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 999378003318 lipoyl attachment site [posttranslational modification]; other site 999378003319 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 999378003320 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 999378003321 metal binding site [ion binding]; metal-binding site 999378003322 dimer interface [polypeptide binding]; other site 999378003323 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 999378003324 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 999378003325 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 999378003326 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 999378003327 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 999378003328 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 999378003329 Walker A/P-loop; other site 999378003330 ATP binding site [chemical binding]; other site 999378003331 Q-loop/lid; other site 999378003332 ABC transporter signature motif; other site 999378003333 Walker B; other site 999378003334 D-loop; other site 999378003335 H-loop/switch region; other site 999378003336 NIL domain; Region: NIL; pfam09383 999378003337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378003338 dimer interface [polypeptide binding]; other site 999378003339 conserved gate region; other site 999378003340 ABC-ATPase subunit interface; other site 999378003341 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 999378003342 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 999378003343 Walker A/P-loop; other site 999378003344 ATP binding site [chemical binding]; other site 999378003345 Q-loop/lid; other site 999378003346 ABC transporter signature motif; other site 999378003347 Walker B; other site 999378003348 D-loop; other site 999378003349 H-loop/switch region; other site 999378003350 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 999378003351 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 999378003352 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 999378003353 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 999378003354 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 999378003355 catalytic residue [active] 999378003356 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 999378003357 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 999378003358 trimerization site [polypeptide binding]; other site 999378003359 active site 999378003360 FeS assembly protein SufB; Region: sufB; TIGR01980 999378003361 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 999378003362 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 999378003363 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 999378003364 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 999378003365 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378003366 active site 999378003367 motif I; other site 999378003368 motif II; other site 999378003369 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999378003370 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999378003371 non-specific DNA binding site [nucleotide binding]; other site 999378003372 salt bridge; other site 999378003373 sequence-specific DNA binding site [nucleotide binding]; other site 999378003374 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 999378003375 Ligand Binding Site [chemical binding]; other site 999378003376 recombination factor protein RarA; Reviewed; Region: PRK13342 999378003377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999378003378 Walker A motif; other site 999378003379 ATP binding site [chemical binding]; other site 999378003380 Walker B motif; other site 999378003381 arginine finger; other site 999378003382 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 999378003383 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 999378003384 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 999378003385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 999378003386 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 999378003387 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 999378003388 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 999378003389 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 999378003390 putative L-serine binding site [chemical binding]; other site 999378003391 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 999378003392 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 999378003393 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 999378003394 catalytic core [active] 999378003395 methionine sulfoxide reductase A; Provisional; Region: PRK14054 999378003396 short chain dehydrogenase; Provisional; Region: PRK06197 999378003397 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 999378003398 putative NAD(P) binding site [chemical binding]; other site 999378003399 active site 999378003400 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 999378003401 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 999378003402 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 999378003403 active site 999378003404 hypothetical protein; Provisional; Region: PRK07329 999378003405 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 999378003406 active site 999378003407 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 999378003408 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 999378003409 peptide binding site [polypeptide binding]; other site 999378003410 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 999378003411 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 999378003412 dimer interface [polypeptide binding]; other site 999378003413 phosphorylation site [posttranslational modification] 999378003414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999378003415 ATP binding site [chemical binding]; other site 999378003416 Mg2+ binding site [ion binding]; other site 999378003417 G-X-G motif; other site 999378003418 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 999378003419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999378003420 active site 999378003421 phosphorylation site [posttranslational modification] 999378003422 intermolecular recognition site; other site 999378003423 dimerization interface [polypeptide binding]; other site 999378003424 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 999378003425 DNA binding site [nucleotide binding] 999378003426 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 999378003427 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378003428 Walker A/P-loop; other site 999378003429 ATP binding site [chemical binding]; other site 999378003430 Q-loop/lid; other site 999378003431 ABC transporter signature motif; other site 999378003432 Walker B; other site 999378003433 D-loop; other site 999378003434 H-loop/switch region; other site 999378003435 Transcriptional regulator [Transcription]; Region: LysR; COG0583 999378003436 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 999378003437 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 999378003438 dimerization interface [polypeptide binding]; other site 999378003439 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 999378003440 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 999378003441 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 999378003442 NADH(P)-binding; Region: NAD_binding_10; pfam13460 999378003443 NAD(P) binding site [chemical binding]; other site 999378003444 active site 999378003445 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999378003446 dimerization interface [polypeptide binding]; other site 999378003447 putative DNA binding site [nucleotide binding]; other site 999378003448 putative Zn2+ binding site [ion binding]; other site 999378003449 glutathionine S-transferase; Provisional; Region: PRK10542 999378003450 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 999378003451 C-terminal domain interface [polypeptide binding]; other site 999378003452 GSH binding site (G-site) [chemical binding]; other site 999378003453 dimer interface [polypeptide binding]; other site 999378003454 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 999378003455 dimer interface [polypeptide binding]; other site 999378003456 substrate binding pocket (H-site) [chemical binding]; other site 999378003457 N-terminal domain interface [polypeptide binding]; other site 999378003458 SAP domain; Region: SAP; pfam02037 999378003459 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999378003460 Coenzyme A binding pocket [chemical binding]; other site 999378003461 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999378003462 Coenzyme A binding pocket [chemical binding]; other site 999378003463 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999378003464 Coenzyme A binding pocket [chemical binding]; other site 999378003465 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 999378003466 EDD domain protein, DegV family; Region: DegV; TIGR00762 999378003467 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 999378003468 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 999378003469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999378003470 active site 999378003471 phosphorylation site [posttranslational modification] 999378003472 intermolecular recognition site; other site 999378003473 dimerization interface [polypeptide binding]; other site 999378003474 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 999378003475 DNA binding residues [nucleotide binding] 999378003476 dimerization interface [polypeptide binding]; other site 999378003477 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 999378003478 Histidine kinase; Region: HisKA_3; pfam07730 999378003479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999378003480 ATP binding site [chemical binding]; other site 999378003481 Mg2+ binding site [ion binding]; other site 999378003482 G-X-G motif; other site 999378003483 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 999378003484 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 999378003485 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 999378003486 Walker A/P-loop; other site 999378003487 ATP binding site [chemical binding]; other site 999378003488 Q-loop/lid; other site 999378003489 ABC transporter signature motif; other site 999378003490 Walker B; other site 999378003491 D-loop; other site 999378003492 H-loop/switch region; other site 999378003493 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 999378003494 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 999378003495 DNA binding residues [nucleotide binding] 999378003496 dimer interface [polypeptide binding]; other site 999378003497 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 999378003498 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 999378003499 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 999378003500 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999378003501 Coenzyme A binding pocket [chemical binding]; other site 999378003502 RelB antitoxin; Region: RelB; cl01171 999378003503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 999378003504 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 999378003505 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 999378003506 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 999378003507 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 999378003508 RNA binding site [nucleotide binding]; other site 999378003509 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 999378003510 Helix-turn-helix domain; Region: HTH_38; pfam13936 999378003511 Integrase core domain; Region: rve; pfam00665 999378003512 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 999378003513 Transposase domain (DUF772); Region: DUF772; pfam05598 999378003514 AAA-like domain; Region: AAA_10; pfam12846 999378003515 Domain of unknown function DUF87; Region: DUF87; pfam01935 999378003516 SIR2-like domain; Region: SIR2_2; pfam13289 999378003517 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 999378003518 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 999378003519 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 999378003520 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 999378003521 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 999378003522 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 999378003523 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 999378003524 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 999378003525 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 999378003526 RNA binding surface [nucleotide binding]; other site 999378003527 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 999378003528 GAF domain; Region: GAF_2; pfam13185 999378003529 septation ring formation regulator EzrA; Provisional; Region: PRK04778 999378003530 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 999378003531 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 999378003532 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 999378003533 catalytic residue [active] 999378003534 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 999378003535 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 999378003536 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 999378003537 Ligand Binding Site [chemical binding]; other site 999378003538 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 999378003539 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 999378003540 CoA binding domain; Region: CoA_binding; pfam02629 999378003541 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 999378003542 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 999378003543 active site 999378003544 HIGH motif; other site 999378003545 nucleotide binding site [chemical binding]; other site 999378003546 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 999378003547 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 999378003548 active site 999378003549 KMSKS motif; other site 999378003550 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 999378003551 tRNA binding surface [nucleotide binding]; other site 999378003552 anticodon binding site; other site 999378003553 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 999378003554 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 999378003555 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 999378003556 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 999378003557 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378003558 motif II; other site 999378003559 hypothetical protein; Reviewed; Region: PRK00024 999378003560 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 999378003561 MPN+ (JAMM) motif; other site 999378003562 Zinc-binding site [ion binding]; other site 999378003563 rod shape-determining protein MreB; Provisional; Region: PRK13927 999378003564 MreB and similar proteins; Region: MreB_like; cd10225 999378003565 nucleotide binding site [chemical binding]; other site 999378003566 Mg binding site [ion binding]; other site 999378003567 putative protofilament interaction site [polypeptide binding]; other site 999378003568 RodZ interaction site [polypeptide binding]; other site 999378003569 rod shape-determining protein MreC; Provisional; Region: PRK13922 999378003570 rod shape-determining protein MreC; Region: MreC; pfam04085 999378003571 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 999378003572 septum formation inhibitor; Reviewed; Region: minC; PRK00513 999378003573 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 999378003574 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 999378003575 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 999378003576 Switch I; other site 999378003577 Switch II; other site 999378003578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378003579 dimer interface [polypeptide binding]; other site 999378003580 conserved gate region; other site 999378003581 putative PBP binding loops; other site 999378003582 ABC-ATPase subunit interface; other site 999378003583 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 999378003584 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378003585 Walker A/P-loop; other site 999378003586 ATP binding site [chemical binding]; other site 999378003587 Q-loop/lid; other site 999378003588 ABC transporter signature motif; other site 999378003589 Walker B; other site 999378003590 D-loop; other site 999378003591 H-loop/switch region; other site 999378003592 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 999378003593 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 999378003594 substrate binding pocket [chemical binding]; other site 999378003595 membrane-bound complex binding site; other site 999378003596 hinge residues; other site 999378003597 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 999378003598 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 999378003599 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 999378003600 putative active site [active] 999378003601 catalytic site [active] 999378003602 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 999378003603 putative active site [active] 999378003604 catalytic site [active] 999378003605 cell division protein MraZ; Reviewed; Region: PRK00326 999378003606 MraZ protein; Region: MraZ; pfam02381 999378003607 MraZ protein; Region: MraZ; pfam02381 999378003608 MraW methylase family; Region: Methyltransf_5; pfam01795 999378003609 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 999378003610 Cell division protein FtsL; Region: FtsL; cl11433 999378003611 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 999378003612 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 999378003613 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 999378003614 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 999378003615 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 999378003616 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 999378003617 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 999378003618 Mg++ binding site [ion binding]; other site 999378003619 putative catalytic motif [active] 999378003620 putative substrate binding site [chemical binding]; other site 999378003621 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 999378003622 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 999378003623 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 999378003624 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 999378003625 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 999378003626 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 999378003627 active site 999378003628 homodimer interface [polypeptide binding]; other site 999378003629 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 999378003630 Cell division protein FtsQ; Region: FtsQ; pfam03799 999378003631 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 999378003632 Cell division protein FtsA; Region: FtsA; smart00842 999378003633 Cell division protein FtsA; Region: FtsA; pfam14450 999378003634 cell division protein FtsZ; Validated; Region: PRK09330 999378003635 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 999378003636 nucleotide binding site [chemical binding]; other site 999378003637 SulA interaction site; other site 999378003638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 999378003639 YGGT family; Region: YGGT; pfam02325 999378003640 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 999378003641 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 999378003642 RNA binding surface [nucleotide binding]; other site 999378003643 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 999378003644 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 999378003645 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 999378003646 dimer interface [polypeptide binding]; other site 999378003647 ADP-ribose binding site [chemical binding]; other site 999378003648 active site 999378003649 nudix motif; other site 999378003650 metal binding site [ion binding]; metal-binding site 999378003651 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 999378003652 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 999378003653 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 999378003654 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 999378003655 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 999378003656 catalytic residue [active] 999378003657 Putative amino acid metabolism; Region: DUF1831; pfam08866 999378003658 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378003659 Walker A/P-loop; other site 999378003660 ATP binding site [chemical binding]; other site 999378003661 Q-loop/lid; other site 999378003662 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378003663 ABC transporter signature motif; other site 999378003664 Walker B; other site 999378003665 D-loop; other site 999378003666 H-loop/switch region; other site 999378003667 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378003668 AAA domain; Region: AAA_21; pfam13304 999378003669 Walker A/P-loop; other site 999378003670 ATP binding site [chemical binding]; other site 999378003671 Q-loop/lid; other site 999378003672 ABC transporter signature motif; other site 999378003673 Walker B; other site 999378003674 D-loop; other site 999378003675 H-loop/switch region; other site 999378003676 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 999378003677 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 999378003678 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 999378003679 catalytic core [active] 999378003680 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 999378003681 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 999378003682 AAA domain; Region: AAA_30; pfam13604 999378003683 Family description; Region: UvrD_C_2; pfam13538 999378003684 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 999378003685 Sterol carrier protein domain; Region: SCP2_2; pfam13530 999378003686 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 999378003687 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 999378003688 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 999378003689 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 999378003690 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 999378003691 active site 999378003692 catalytic residues [active] 999378003693 metal binding site [ion binding]; metal-binding site 999378003694 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 999378003695 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 999378003696 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 999378003697 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 999378003698 TPP-binding site [chemical binding]; other site 999378003699 tetramer interface [polypeptide binding]; other site 999378003700 heterodimer interface [polypeptide binding]; other site 999378003701 phosphorylation loop region [posttranslational modification] 999378003702 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 999378003703 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 999378003704 alpha subunit interface [polypeptide binding]; other site 999378003705 TPP binding site [chemical binding]; other site 999378003706 heterodimer interface [polypeptide binding]; other site 999378003707 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 999378003708 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 999378003709 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 999378003710 E3 interaction surface; other site 999378003711 lipoyl attachment site [posttranslational modification]; other site 999378003712 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 999378003713 E3 interaction surface; other site 999378003714 lipoyl attachment site [posttranslational modification]; other site 999378003715 e3 binding domain; Region: E3_binding; pfam02817 999378003716 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 999378003717 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 999378003718 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 999378003719 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 999378003720 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 999378003721 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 999378003722 NAD(P) binding site [chemical binding]; other site 999378003723 substrate binding site [chemical binding]; other site 999378003724 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 999378003725 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 999378003726 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 999378003727 active site 999378003728 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 999378003729 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 999378003730 G1 box; other site 999378003731 putative GEF interaction site [polypeptide binding]; other site 999378003732 GTP/Mg2+ binding site [chemical binding]; other site 999378003733 Switch I region; other site 999378003734 G2 box; other site 999378003735 G3 box; other site 999378003736 Switch II region; other site 999378003737 G4 box; other site 999378003738 G5 box; other site 999378003739 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 999378003740 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 999378003741 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 999378003742 pyruvate carboxylase; Reviewed; Region: PRK12999 999378003743 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 999378003744 ATP-grasp domain; Region: ATP-grasp_4; cl17255 999378003745 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 999378003746 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 999378003747 active site 999378003748 catalytic residues [active] 999378003749 metal binding site [ion binding]; metal-binding site 999378003750 homodimer binding site [polypeptide binding]; other site 999378003751 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 999378003752 carboxyltransferase (CT) interaction site; other site 999378003753 biotinylation site [posttranslational modification]; other site 999378003754 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 999378003755 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 999378003756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999378003757 S-adenosylmethionine binding site [chemical binding]; other site 999378003758 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 999378003759 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 999378003760 active site 999378003761 (T/H)XGH motif; other site 999378003762 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 999378003763 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 999378003764 protein binding site [polypeptide binding]; other site 999378003765 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 999378003766 SLBB domain; Region: SLBB; pfam10531 999378003767 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 999378003768 Helix-hairpin-helix motif; Region: HHH; pfam00633 999378003769 Competence protein; Region: Competence; pfam03772 999378003770 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 999378003771 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 999378003772 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 999378003773 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 999378003774 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 999378003775 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 999378003776 16S/18S rRNA binding site [nucleotide binding]; other site 999378003777 S13e-L30e interaction site [polypeptide binding]; other site 999378003778 25S rRNA binding site [nucleotide binding]; other site 999378003779 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 999378003780 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 999378003781 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 999378003782 elongation factor Tu; Reviewed; Region: PRK00049 999378003783 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 999378003784 G1 box; other site 999378003785 GEF interaction site [polypeptide binding]; other site 999378003786 GTP/Mg2+ binding site [chemical binding]; other site 999378003787 Switch I region; other site 999378003788 G2 box; other site 999378003789 G3 box; other site 999378003790 Switch II region; other site 999378003791 G4 box; other site 999378003792 G5 box; other site 999378003793 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 999378003794 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 999378003795 Antibiotic Binding Site [chemical binding]; other site 999378003796 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 999378003797 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999378003798 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 999378003799 Walker A/P-loop; other site 999378003800 ATP binding site [chemical binding]; other site 999378003801 Q-loop/lid; other site 999378003802 ABC transporter signature motif; other site 999378003803 Walker B; other site 999378003804 D-loop; other site 999378003805 H-loop/switch region; other site 999378003806 trigger factor; Provisional; Region: tig; PRK01490 999378003807 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 999378003808 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 999378003809 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 999378003810 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 999378003811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999378003812 Walker A motif; other site 999378003813 ATP binding site [chemical binding]; other site 999378003814 Walker B motif; other site 999378003815 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 999378003816 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 999378003817 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 999378003818 G1 box; other site 999378003819 GTP/Mg2+ binding site [chemical binding]; other site 999378003820 Switch I region; other site 999378003821 G2 box; other site 999378003822 G3 box; other site 999378003823 Switch II region; other site 999378003824 G4 box; other site 999378003825 G5 box; other site 999378003826 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 999378003827 putative metal binding site [ion binding]; other site 999378003828 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 999378003829 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 999378003830 substrate binding pocket [chemical binding]; other site 999378003831 membrane-bound complex binding site; other site 999378003832 hinge residues; other site 999378003833 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 999378003834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378003835 dimer interface [polypeptide binding]; other site 999378003836 conserved gate region; other site 999378003837 putative PBP binding loops; other site 999378003838 ABC-ATPase subunit interface; other site 999378003839 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 999378003840 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 999378003841 Walker A/P-loop; other site 999378003842 ATP binding site [chemical binding]; other site 999378003843 Q-loop/lid; other site 999378003844 ABC transporter signature motif; other site 999378003845 Walker B; other site 999378003846 D-loop; other site 999378003847 H-loop/switch region; other site 999378003848 Pleckstrin homology-like domain; Region: PH-like; cl17171 999378003849 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 999378003850 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 999378003851 GIY-YIG motif/motif A; other site 999378003852 active site 999378003853 catalytic site [active] 999378003854 putative DNA binding site [nucleotide binding]; other site 999378003855 metal binding site [ion binding]; metal-binding site 999378003856 UvrB/uvrC motif; Region: UVR; pfam02151 999378003857 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 999378003858 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 999378003859 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 999378003860 active site 999378003861 phosphorylation site [posttranslational modification] 999378003862 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 999378003863 active site 999378003864 P-loop; other site 999378003865 phosphorylation site [posttranslational modification] 999378003866 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 999378003867 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 999378003868 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 999378003869 putative substrate binding site [chemical binding]; other site 999378003870 putative ATP binding site [chemical binding]; other site 999378003871 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 999378003872 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 999378003873 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 999378003874 GTPase CgtA; Reviewed; Region: obgE; PRK12297 999378003875 GTP1/OBG; Region: GTP1_OBG; pfam01018 999378003876 Obg GTPase; Region: Obg; cd01898 999378003877 G1 box; other site 999378003878 GTP/Mg2+ binding site [chemical binding]; other site 999378003879 Switch I region; other site 999378003880 G2 box; other site 999378003881 G3 box; other site 999378003882 Switch II region; other site 999378003883 G4 box; other site 999378003884 G5 box; other site 999378003885 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 999378003886 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 999378003887 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 999378003888 catalytic triad [active] 999378003889 catalytic triad [active] 999378003890 oxyanion hole [active] 999378003891 ribonuclease Z; Region: RNase_Z; TIGR02651 999378003892 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 999378003893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 999378003894 NAD(P) binding site [chemical binding]; other site 999378003895 active site 999378003896 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 999378003897 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 999378003898 Clp amino terminal domain; Region: Clp_N; pfam02861 999378003899 Clp amino terminal domain; Region: Clp_N; pfam02861 999378003900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999378003901 Walker A motif; other site 999378003902 ATP binding site [chemical binding]; other site 999378003903 Walker B motif; other site 999378003904 arginine finger; other site 999378003905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999378003906 Walker A motif; other site 999378003907 ATP binding site [chemical binding]; other site 999378003908 Walker B motif; other site 999378003909 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 999378003910 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 999378003911 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 999378003912 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 999378003913 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 999378003914 active site 999378003915 metal binding site [ion binding]; metal-binding site 999378003916 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 999378003917 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 999378003918 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 999378003919 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 999378003920 active site 999378003921 PHP Thumb interface [polypeptide binding]; other site 999378003922 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 999378003923 generic binding surface I; other site 999378003924 generic binding surface II; other site 999378003925 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 999378003926 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 999378003927 active site 999378003928 ADP/pyrophosphate binding site [chemical binding]; other site 999378003929 dimerization interface [polypeptide binding]; other site 999378003930 allosteric effector site; other site 999378003931 fructose-1,6-bisphosphate binding site; other site 999378003932 pyruvate kinase; Provisional; Region: PRK06354 999378003933 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 999378003934 domain interfaces; other site 999378003935 active site 999378003936 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 999378003937 Protein of unknown function (DUF441); Region: DUF441; pfam04284 999378003938 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 999378003939 S1 domain; Region: S1_2; pfam13509 999378003940 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 999378003941 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 999378003942 active site 999378003943 Int/Topo IB signature motif; other site 999378003944 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 999378003945 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 999378003946 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 999378003947 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 999378003948 RNA binding surface [nucleotide binding]; other site 999378003949 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 999378003950 active site 999378003951 Predicted membrane protein [Function unknown]; Region: COG3601 999378003952 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 999378003953 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 999378003954 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 999378003955 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 999378003956 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 999378003957 ATP binding site [chemical binding]; other site 999378003958 putative Mg++ binding site [ion binding]; other site 999378003959 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 999378003960 nucleotide binding region [chemical binding]; other site 999378003961 ATP-binding site [chemical binding]; other site 999378003962 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999378003963 cytidylate kinase; Provisional; Region: cmk; PRK00023 999378003964 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 999378003965 CMP-binding site; other site 999378003966 The sites determining sugar specificity; other site 999378003967 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 999378003968 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 999378003969 RNA binding site [nucleotide binding]; other site 999378003970 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 999378003971 RNA binding site [nucleotide binding]; other site 999378003972 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 999378003973 RNA binding site [nucleotide binding]; other site 999378003974 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 999378003975 RNA binding site [nucleotide binding]; other site 999378003976 GTP-binding protein Der; Reviewed; Region: PRK00093 999378003977 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 999378003978 G1 box; other site 999378003979 GTP/Mg2+ binding site [chemical binding]; other site 999378003980 Switch I region; other site 999378003981 G2 box; other site 999378003982 Switch II region; other site 999378003983 G3 box; other site 999378003984 G4 box; other site 999378003985 G5 box; other site 999378003986 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 999378003987 G1 box; other site 999378003988 GTP/Mg2+ binding site [chemical binding]; other site 999378003989 Switch I region; other site 999378003990 G2 box; other site 999378003991 G3 box; other site 999378003992 Switch II region; other site 999378003993 G4 box; other site 999378003994 G5 box; other site 999378003995 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 999378003996 IHF dimer interface [polypeptide binding]; other site 999378003997 IHF - DNA interface [nucleotide binding]; other site 999378003998 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 999378003999 TPR motif; other site 999378004000 binding surface 999378004001 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 999378004002 binding surface 999378004003 TPR motif; other site 999378004004 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 999378004005 binding surface 999378004006 TPR motif; other site 999378004007 TPR repeat; Region: TPR_11; pfam13414 999378004008 Uncharacterized conserved protein [Function unknown]; Region: COG1284 999378004009 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 999378004010 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 999378004011 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 999378004012 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 999378004013 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 999378004014 active site 999378004015 NTP binding site [chemical binding]; other site 999378004016 metal binding triad [ion binding]; metal-binding site 999378004017 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 999378004018 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 999378004019 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 999378004020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378004021 Walker A/P-loop; other site 999378004022 ATP binding site [chemical binding]; other site 999378004023 Q-loop/lid; other site 999378004024 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 999378004025 ABC transporter signature motif; other site 999378004026 Walker B; other site 999378004027 D-loop; other site 999378004028 ABC transporter; Region: ABC_tran_2; pfam12848 999378004029 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 999378004030 thymidylate synthase; Region: thym_sym; TIGR03284 999378004031 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 999378004032 dimerization interface [polypeptide binding]; other site 999378004033 active site 999378004034 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 999378004035 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 999378004036 folate binding site [chemical binding]; other site 999378004037 NADP+ binding site [chemical binding]; other site 999378004038 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 999378004039 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 999378004040 EDD domain protein, DegV family; Region: DegV; TIGR00762 999378004041 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 999378004042 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 999378004043 active site 999378004044 catalytic triad [active] 999378004045 oxyanion hole [active] 999378004046 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 999378004047 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 999378004048 hypothetical protein; Provisional; Region: PRK13672 999378004049 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 999378004050 C-terminal peptidase (prc); Region: prc; TIGR00225 999378004051 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 999378004052 protein binding site [polypeptide binding]; other site 999378004053 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 999378004054 Catalytic dyad [active] 999378004055 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 999378004056 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 999378004057 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 999378004058 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 999378004059 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999378004060 sequence-specific DNA binding site [nucleotide binding]; other site 999378004061 salt bridge; other site 999378004062 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 999378004063 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 999378004064 GTP/Mg2+ binding site [chemical binding]; other site 999378004065 G4 box; other site 999378004066 G5 box; other site 999378004067 G1 box; other site 999378004068 Switch I region; other site 999378004069 G2 box; other site 999378004070 G3 box; other site 999378004071 Switch II region; other site 999378004072 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 999378004073 RNA/DNA hybrid binding site [nucleotide binding]; other site 999378004074 active site 999378004075 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 999378004076 DNA protecting protein DprA; Region: dprA; TIGR00732 999378004077 DNA topoisomerase I; Validated; Region: PRK05582 999378004078 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 999378004079 active site 999378004080 interdomain interaction site; other site 999378004081 putative metal-binding site [ion binding]; other site 999378004082 nucleotide binding site [chemical binding]; other site 999378004083 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 999378004084 domain I; other site 999378004085 DNA binding groove [nucleotide binding] 999378004086 phosphate binding site [ion binding]; other site 999378004087 domain II; other site 999378004088 domain III; other site 999378004089 nucleotide binding site [chemical binding]; other site 999378004090 catalytic site [active] 999378004091 domain IV; other site 999378004092 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 999378004093 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 999378004094 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 999378004095 Glucose inhibited division protein A; Region: GIDA; pfam01134 999378004096 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 999378004097 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 999378004098 active site 999378004099 Int/Topo IB signature motif; other site 999378004100 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 999378004101 active site 999378004102 HslU subunit interaction site [polypeptide binding]; other site 999378004103 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 999378004104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999378004105 Walker A motif; other site 999378004106 ATP binding site [chemical binding]; other site 999378004107 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 999378004108 Walker B motif; other site 999378004109 arginine finger; other site 999378004110 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 999378004111 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 999378004112 active site 999378004113 catalytic residues [active] 999378004114 membrane protein; Provisional; Region: PRK14392 999378004115 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 999378004116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999378004117 Mg2+ binding site [ion binding]; other site 999378004118 G-X-G motif; other site 999378004119 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 999378004120 anchoring element; other site 999378004121 dimer interface [polypeptide binding]; other site 999378004122 ATP binding site [chemical binding]; other site 999378004123 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 999378004124 active site 999378004125 putative metal-binding site [ion binding]; other site 999378004126 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 999378004127 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 999378004128 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 999378004129 CAP-like domain; other site 999378004130 active site 999378004131 primary dimer interface [polypeptide binding]; other site 999378004132 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 999378004133 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 999378004134 Pyruvate formate lyase 1; Region: PFL1; cd01678 999378004135 coenzyme A binding site [chemical binding]; other site 999378004136 active site 999378004137 catalytic residues [active] 999378004138 glycine loop; other site 999378004139 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 999378004140 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 999378004141 FeS/SAM binding site; other site 999378004142 Transcriptional regulator [Transcription]; Region: LysR; COG0583 999378004143 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 999378004144 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 999378004145 dimerization interface [polypeptide binding]; other site 999378004146 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 999378004147 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 999378004148 DHHA2 domain; Region: DHHA2; pfam02833 999378004149 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 999378004150 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 999378004151 active site 999378004152 DNA binding site [nucleotide binding] 999378004153 Int/Topo IB signature motif; other site 999378004154 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 999378004155 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 999378004156 Walker A/P-loop; other site 999378004157 ATP binding site [chemical binding]; other site 999378004158 Q-loop/lid; other site 999378004159 ABC transporter signature motif; other site 999378004160 Walker B; other site 999378004161 D-loop; other site 999378004162 H-loop/switch region; other site 999378004163 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 999378004164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999378004165 ATP binding site [chemical binding]; other site 999378004166 Mg2+ binding site [ion binding]; other site 999378004167 G-X-G motif; other site 999378004168 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 999378004169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999378004170 active site 999378004171 phosphorylation site [posttranslational modification] 999378004172 intermolecular recognition site; other site 999378004173 dimerization interface [polypeptide binding]; other site 999378004174 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 999378004175 DNA binding site [nucleotide binding] 999378004176 H+ Antiporter protein; Region: 2A0121; TIGR00900 999378004177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378004178 putative substrate translocation pore; other site 999378004179 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999378004180 Coenzyme A binding pocket [chemical binding]; other site 999378004181 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 999378004182 dimer interface [polypeptide binding]; other site 999378004183 FMN binding site [chemical binding]; other site 999378004184 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 999378004185 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 999378004186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999378004187 homodimer interface [polypeptide binding]; other site 999378004188 catalytic residue [active] 999378004189 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 999378004190 metal binding site [ion binding]; metal-binding site 999378004191 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 999378004192 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 999378004193 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 999378004194 substrate binding site [chemical binding]; other site 999378004195 glutamase interaction surface [polypeptide binding]; other site 999378004196 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 999378004197 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 999378004198 catalytic residues [active] 999378004199 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 999378004200 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 999378004201 putative active site [active] 999378004202 oxyanion strand; other site 999378004203 catalytic triad [active] 999378004204 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 999378004205 4-fold oligomerization interface [polypeptide binding]; other site 999378004206 putative active site pocket [active] 999378004207 metal binding residues [ion binding]; metal-binding site 999378004208 3-fold/trimer interface [polypeptide binding]; other site 999378004209 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 999378004210 histidinol dehydrogenase; Region: hisD; TIGR00069 999378004211 NAD binding site [chemical binding]; other site 999378004212 dimerization interface [polypeptide binding]; other site 999378004213 product binding site; other site 999378004214 substrate binding site [chemical binding]; other site 999378004215 zinc binding site [ion binding]; other site 999378004216 catalytic residues [active] 999378004217 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 999378004218 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 999378004219 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 999378004220 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 999378004221 dimer interface [polypeptide binding]; other site 999378004222 motif 1; other site 999378004223 active site 999378004224 motif 2; other site 999378004225 motif 3; other site 999378004226 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 999378004227 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 999378004228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999378004229 homodimer interface [polypeptide binding]; other site 999378004230 catalytic residue [active] 999378004231 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 999378004232 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 999378004233 dimer interface [polypeptide binding]; other site 999378004234 ADP-ribose binding site [chemical binding]; other site 999378004235 active site 999378004236 nudix motif; other site 999378004237 metal binding site [ion binding]; metal-binding site 999378004238 EDD domain protein, DegV family; Region: DegV; TIGR00762 999378004239 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 999378004240 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 999378004241 Domain of unknown function (DUF814); Region: DUF814; pfam05670 999378004242 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Sulfolobus solfataricus (Ss) and its homologs from archaea and bacteria; Region: NTP-PPase_SsMazG; cd11535 999378004243 metal binding site [ion binding]; metal-binding site 999378004244 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 999378004245 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 999378004246 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 999378004247 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 999378004248 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 999378004249 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 999378004250 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 999378004251 E3 interaction surface; other site 999378004252 lipoyl attachment site [posttranslational modification]; other site 999378004253 e3 binding domain; Region: E3_binding; pfam02817 999378004254 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 999378004255 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 999378004256 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 999378004257 alpha subunit interface [polypeptide binding]; other site 999378004258 TPP binding site [chemical binding]; other site 999378004259 heterodimer interface [polypeptide binding]; other site 999378004260 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 999378004261 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 999378004262 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 999378004263 tetramer interface [polypeptide binding]; other site 999378004264 TPP-binding site [chemical binding]; other site 999378004265 heterodimer interface [polypeptide binding]; other site 999378004266 phosphorylation loop region [posttranslational modification] 999378004267 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 999378004268 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 999378004269 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 999378004270 butyrate kinase; Provisional; Region: PRK03011 999378004271 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 999378004272 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 999378004273 active site 999378004274 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 999378004275 active site 999378004276 dimer interface [polypeptide binding]; other site 999378004277 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 999378004278 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 999378004279 heterodimer interface [polypeptide binding]; other site 999378004280 active site 999378004281 FMN binding site [chemical binding]; other site 999378004282 homodimer interface [polypeptide binding]; other site 999378004283 substrate binding site [chemical binding]; other site 999378004284 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 999378004285 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 999378004286 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 999378004287 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 999378004288 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 999378004289 ATP-grasp domain; Region: ATP-grasp_4; cl17255 999378004290 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 999378004291 IMP binding site; other site 999378004292 dimer interface [polypeptide binding]; other site 999378004293 interdomain contacts; other site 999378004294 partial ornithine binding site; other site 999378004295 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 999378004296 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 999378004297 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 999378004298 catalytic site [active] 999378004299 subunit interface [polypeptide binding]; other site 999378004300 dihydroorotase; Validated; Region: pyrC; PRK09357 999378004301 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 999378004302 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 999378004303 active site 999378004304 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 999378004305 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 999378004306 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 999378004307 uracil transporter; Provisional; Region: PRK10720 999378004308 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 999378004309 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 999378004310 active site 999378004311 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 999378004312 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 999378004313 RNA binding surface [nucleotide binding]; other site 999378004314 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 999378004315 active site 999378004316 lipoprotein signal peptidase; Provisional; Region: PRK14797 999378004317 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 999378004318 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 999378004319 Potassium binding sites [ion binding]; other site 999378004320 Cesium cation binding sites [ion binding]; other site 999378004321 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 999378004322 RNA/DNA hybrid binding site [nucleotide binding]; other site 999378004323 active site 999378004324 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 999378004325 dimer interface [polypeptide binding]; other site 999378004326 FMN binding site [chemical binding]; other site 999378004327 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 999378004328 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 999378004329 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 999378004330 putative active site [active] 999378004331 catalytic site [active] 999378004332 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 999378004333 putative active site [active] 999378004334 catalytic site [active] 999378004335 Mga helix-turn-helix domain; Region: Mga; pfam05043 999378004336 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 999378004337 catalytic residues [active] 999378004338 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 999378004339 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 999378004340 Class I ribonucleotide reductase; Region: RNR_I; cd01679 999378004341 active site 999378004342 dimer interface [polypeptide binding]; other site 999378004343 catalytic residues [active] 999378004344 effector binding site; other site 999378004345 R2 peptide binding site; other site 999378004346 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 999378004347 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 999378004348 dimer interface [polypeptide binding]; other site 999378004349 putative radical transfer pathway; other site 999378004350 diiron center [ion binding]; other site 999378004351 tyrosyl radical; other site 999378004352 Transcriptional regulator [Transcription]; Region: LysR; COG0583 999378004353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 999378004354 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 999378004355 dimerization interface [polypeptide binding]; other site 999378004356 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 999378004357 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 999378004358 active site 999378004359 Zn binding site [ion binding]; other site 999378004360 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 999378004361 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 999378004362 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 999378004363 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 999378004364 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 999378004365 putative ligand binding site [chemical binding]; other site 999378004366 NAD binding site [chemical binding]; other site 999378004367 catalytic site [active] 999378004368 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 999378004369 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 999378004370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 999378004371 cell division protein GpsB; Provisional; Region: PRK14127 999378004372 DivIVA domain; Region: DivI1A_domain; TIGR03544 999378004373 hypothetical protein; Provisional; Region: PRK13660 999378004374 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 999378004375 Transglycosylase; Region: Transgly; pfam00912 999378004376 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 999378004377 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 999378004378 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 999378004379 catalytic motif [active] 999378004380 Zn binding site [ion binding]; other site 999378004381 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 999378004382 endonuclease III; Region: ENDO3c; smart00478 999378004383 minor groove reading motif; other site 999378004384 helix-hairpin-helix signature motif; other site 999378004385 substrate binding pocket [chemical binding]; other site 999378004386 active site 999378004387 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 999378004388 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 999378004389 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 999378004390 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 999378004391 putative dimer interface [polypeptide binding]; other site 999378004392 putative anticodon binding site; other site 999378004393 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 999378004394 homodimer interface [polypeptide binding]; other site 999378004395 motif 1; other site 999378004396 motif 2; other site 999378004397 active site 999378004398 motif 3; other site 999378004399 aspartate aminotransferase; Provisional; Region: PRK05764 999378004400 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 999378004401 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999378004402 homodimer interface [polypeptide binding]; other site 999378004403 catalytic residue [active] 999378004404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 999378004405 DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407 999378004406 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 999378004407 active site 999378004408 catalytic site [active] 999378004409 substrate binding site [chemical binding]; other site 999378004410 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 999378004411 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 999378004412 DEAD/DEAH box helicase; Region: DEAD; pfam00270 999378004413 ATP binding site [chemical binding]; other site 999378004414 Family description; Region: UvrD_C_2; pfam13538 999378004415 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 999378004416 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 999378004417 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 999378004418 mevalonate kinase; Region: mevalon_kin; TIGR00549 999378004419 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 999378004420 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 999378004421 diphosphomevalonate decarboxylase; Region: PLN02407 999378004422 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 999378004423 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 999378004424 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 999378004425 homotetramer interface [polypeptide binding]; other site 999378004426 FMN binding site [chemical binding]; other site 999378004427 homodimer contacts [polypeptide binding]; other site 999378004428 putative active site [active] 999378004429 putative substrate binding site [chemical binding]; other site 999378004430 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 999378004431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999378004432 S-adenosylmethionine binding site [chemical binding]; other site 999378004433 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 999378004434 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 999378004435 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 999378004436 active site 1 [active] 999378004437 dimer interface [polypeptide binding]; other site 999378004438 hexamer interface [polypeptide binding]; other site 999378004439 active site 2 [active] 999378004440 Uncharacterized conserved protein [Function unknown]; Region: COG0327 999378004441 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 999378004442 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 999378004443 Family of unknown function (DUF633); Region: DUF633; pfam04816 999378004444 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 999378004445 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 999378004446 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 999378004447 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 999378004448 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 999378004449 DNA binding residues [nucleotide binding] 999378004450 DNA primase; Validated; Region: dnaG; PRK05667 999378004451 CHC2 zinc finger; Region: zf-CHC2; pfam01807 999378004452 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 999378004453 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 999378004454 active site 999378004455 metal binding site [ion binding]; metal-binding site 999378004456 interdomain interaction site; other site 999378004457 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 999378004458 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 999378004459 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 999378004460 dimer interface [polypeptide binding]; other site 999378004461 motif 1; other site 999378004462 active site 999378004463 motif 2; other site 999378004464 motif 3; other site 999378004465 Recombination protein O N terminal; Region: RecO_N; pfam11967 999378004466 DNA repair protein RecO; Region: reco; TIGR00613 999378004467 Recombination protein O C terminal; Region: RecO_C; pfam02565 999378004468 GTPase Era; Reviewed; Region: era; PRK00089 999378004469 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 999378004470 G1 box; other site 999378004471 GTP/Mg2+ binding site [chemical binding]; other site 999378004472 Switch I region; other site 999378004473 G2 box; other site 999378004474 Switch II region; other site 999378004475 G3 box; other site 999378004476 G4 box; other site 999378004477 G5 box; other site 999378004478 KH domain; Region: KH_2; pfam07650 999378004479 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 999378004480 active site 999378004481 catalytic motif [active] 999378004482 Zn binding site [ion binding]; other site 999378004483 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 999378004484 metal-binding heat shock protein; Provisional; Region: PRK00016 999378004485 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 999378004486 PhoH-like protein; Region: PhoH; pfam02562 999378004487 Yqey-like protein; Region: YqeY; pfam09424 999378004488 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 999378004489 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 999378004490 endonuclease IV; Provisional; Region: PRK01060 999378004491 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 999378004492 AP (apurinic/apyrimidinic) site pocket; other site 999378004493 DNA interaction; other site 999378004494 Metal-binding active site; metal-binding site 999378004495 Uncharacterized conserved protein [Function unknown]; Region: COG1284 999378004496 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 999378004497 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 999378004498 methionine sulfoxide reductase B; Provisional; Region: PRK00222 999378004499 SelR domain; Region: SelR; pfam01641 999378004500 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 999378004501 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 999378004502 dimer interface [polypeptide binding]; other site 999378004503 anticodon binding site; other site 999378004504 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 999378004505 homodimer interface [polypeptide binding]; other site 999378004506 motif 1; other site 999378004507 active site 999378004508 motif 2; other site 999378004509 GAD domain; Region: GAD; pfam02938 999378004510 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 999378004511 motif 3; other site 999378004512 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 999378004513 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 999378004514 dimer interface [polypeptide binding]; other site 999378004515 motif 1; other site 999378004516 active site 999378004517 motif 2; other site 999378004518 motif 3; other site 999378004519 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 999378004520 anticodon binding site; other site 999378004521 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 999378004522 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 999378004523 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 999378004524 putative NAD(P) binding site [chemical binding]; other site 999378004525 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999378004526 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999378004527 non-specific DNA binding site [nucleotide binding]; other site 999378004528 salt bridge; other site 999378004529 sequence-specific DNA binding site [nucleotide binding]; other site 999378004530 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 999378004531 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 999378004532 Walker A/P-loop; other site 999378004533 ATP binding site [chemical binding]; other site 999378004534 Q-loop/lid; other site 999378004535 ABC transporter signature motif; other site 999378004536 Walker B; other site 999378004537 D-loop; other site 999378004538 H-loop/switch region; other site 999378004539 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 999378004540 Bacterial SH3 domain; Region: SH3_3; pfam08239 999378004541 Bacterial SH3 domain; Region: SH3_3; pfam08239 999378004542 Bacterial SH3 domain homologues; Region: SH3b; smart00287 999378004543 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 999378004544 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 999378004545 active site 999378004546 metal binding site [ion binding]; metal-binding site 999378004547 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 999378004548 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378004549 motif II; other site 999378004550 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 999378004551 putative active site [active] 999378004552 dimerization interface [polypeptide binding]; other site 999378004553 putative tRNAtyr binding site [nucleotide binding]; other site 999378004554 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 999378004555 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 999378004556 Zn2+ binding site [ion binding]; other site 999378004557 Mg2+ binding site [ion binding]; other site 999378004558 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 999378004559 synthetase active site [active] 999378004560 NTP binding site [chemical binding]; other site 999378004561 metal binding site [ion binding]; metal-binding site 999378004562 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 999378004563 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 999378004564 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 999378004565 RNA methyltransferase, RsmE family; Region: TIGR00046 999378004566 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 999378004567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999378004568 S-adenosylmethionine binding site [chemical binding]; other site 999378004569 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 999378004570 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 999378004571 active site 999378004572 DNA binding site [nucleotide binding] 999378004573 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 999378004574 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999378004575 Coenzyme A binding pocket [chemical binding]; other site 999378004576 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 999378004577 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 999378004578 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999378004579 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999378004580 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 999378004581 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 999378004582 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 999378004583 putative deacylase active site [active] 999378004584 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 999378004585 active site 999378004586 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 999378004587 DHH family; Region: DHH; pfam01368 999378004588 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 999378004589 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 999378004590 GTP-binding protein LepA; Provisional; Region: PRK05433 999378004591 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 999378004592 G1 box; other site 999378004593 putative GEF interaction site [polypeptide binding]; other site 999378004594 GTP/Mg2+ binding site [chemical binding]; other site 999378004595 Switch I region; other site 999378004596 G2 box; other site 999378004597 G3 box; other site 999378004598 Switch II region; other site 999378004599 G4 box; other site 999378004600 G5 box; other site 999378004601 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 999378004602 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 999378004603 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 999378004604 chaperone protein DnaJ; Provisional; Region: PRK14276 999378004605 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 999378004606 HSP70 interaction site [polypeptide binding]; other site 999378004607 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 999378004608 substrate binding site [polypeptide binding]; other site 999378004609 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 999378004610 Zn binding sites [ion binding]; other site 999378004611 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 999378004612 dimer interface [polypeptide binding]; other site 999378004613 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 999378004614 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 999378004615 nucleotide binding site [chemical binding]; other site 999378004616 NEF interaction site [polypeptide binding]; other site 999378004617 SBD interface [polypeptide binding]; other site 999378004618 GrpE; Region: GrpE; pfam01025 999378004619 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 999378004620 dimer interface [polypeptide binding]; other site 999378004621 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 999378004622 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 999378004623 HTH domain; Region: HTH_11; pfam08279 999378004624 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 999378004625 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 999378004626 active site 999378004627 Riboflavin kinase; Region: Flavokinase; smart00904 999378004628 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 999378004629 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 999378004630 RNA binding site [nucleotide binding]; other site 999378004631 active site 999378004632 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 999378004633 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 999378004634 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 999378004635 translation initiation factor IF-2; Region: IF-2; TIGR00487 999378004636 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 999378004637 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 999378004638 G1 box; other site 999378004639 putative GEF interaction site [polypeptide binding]; other site 999378004640 GTP/Mg2+ binding site [chemical binding]; other site 999378004641 Switch I region; other site 999378004642 G2 box; other site 999378004643 G3 box; other site 999378004644 Switch II region; other site 999378004645 G4 box; other site 999378004646 G5 box; other site 999378004647 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 999378004648 Translation-initiation factor 2; Region: IF-2; pfam11987 999378004649 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 999378004650 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 999378004651 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 999378004652 putative RNA binding cleft [nucleotide binding]; other site 999378004653 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 999378004654 NusA N-terminal domain; Region: NusA_N; pfam08529 999378004655 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 999378004656 RNA binding site [nucleotide binding]; other site 999378004657 homodimer interface [polypeptide binding]; other site 999378004658 NusA-like KH domain; Region: KH_5; pfam13184 999378004659 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 999378004660 G-X-X-G motif; other site 999378004661 ribosome maturation protein RimP; Reviewed; Region: PRK00092 999378004662 Sm and related proteins; Region: Sm_like; cl00259 999378004663 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 999378004664 putative oligomer interface [polypeptide binding]; other site 999378004665 putative RNA binding site [nucleotide binding]; other site 999378004666 DNA polymerase III PolC; Validated; Region: polC; PRK00448 999378004667 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 999378004668 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 999378004669 generic binding surface II; other site 999378004670 generic binding surface I; other site 999378004671 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 999378004672 active site 999378004673 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 999378004674 active site 999378004675 catalytic site [active] 999378004676 substrate binding site [chemical binding]; other site 999378004677 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 999378004678 prolyl-tRNA synthetase; Provisional; Region: PRK09194 999378004679 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 999378004680 dimer interface [polypeptide binding]; other site 999378004681 motif 1; other site 999378004682 active site 999378004683 motif 2; other site 999378004684 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 999378004685 putative deacylase active site [active] 999378004686 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 999378004687 active site 999378004688 motif 3; other site 999378004689 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 999378004690 anticodon binding site; other site 999378004691 RIP metalloprotease RseP; Region: TIGR00054 999378004692 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 999378004693 active site 999378004694 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 999378004695 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 999378004696 protein binding site [polypeptide binding]; other site 999378004697 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 999378004698 putative substrate binding region [chemical binding]; other site 999378004699 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 999378004700 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 999378004701 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 999378004702 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 999378004703 catalytic residue [active] 999378004704 putative FPP diphosphate binding site; other site 999378004705 putative FPP binding hydrophobic cleft; other site 999378004706 dimer interface [polypeptide binding]; other site 999378004707 putative IPP diphosphate binding site; other site 999378004708 ribosome recycling factor; Reviewed; Region: frr; PRK00083 999378004709 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 999378004710 hinge region; other site 999378004711 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 999378004712 putative nucleotide binding site [chemical binding]; other site 999378004713 uridine monophosphate binding site [chemical binding]; other site 999378004714 homohexameric interface [polypeptide binding]; other site 999378004715 elongation factor Ts; Provisional; Region: tsf; PRK09377 999378004716 UBA/TS-N domain; Region: UBA; pfam00627 999378004717 Elongation factor TS; Region: EF_TS; pfam00889 999378004718 Elongation factor TS; Region: EF_TS; pfam00889 999378004719 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 999378004720 rRNA interaction site [nucleotide binding]; other site 999378004721 S8 interaction site; other site 999378004722 putative laminin-1 binding site; other site 999378004723 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 999378004724 GIY-YIG motif/motif A; other site 999378004725 putative active site [active] 999378004726 putative metal binding site [ion binding]; other site 999378004727 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 999378004728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999378004729 S-adenosylmethionine binding site [chemical binding]; other site 999378004730 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 999378004731 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 999378004732 putative acyl-acceptor binding pocket; other site 999378004733 amino acid transporter; Region: 2A0306; TIGR00909 999378004734 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 999378004735 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 999378004736 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 999378004737 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999378004738 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 999378004739 Walker A/P-loop; other site 999378004740 ATP binding site [chemical binding]; other site 999378004741 Q-loop/lid; other site 999378004742 ABC transporter signature motif; other site 999378004743 Walker B; other site 999378004744 D-loop; other site 999378004745 H-loop/switch region; other site 999378004746 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999378004747 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 999378004748 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378004749 Walker A/P-loop; other site 999378004750 ATP binding site [chemical binding]; other site 999378004751 Q-loop/lid; other site 999378004752 ABC transporter signature motif; other site 999378004753 Walker B; other site 999378004754 D-loop; other site 999378004755 H-loop/switch region; other site 999378004756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 999378004757 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 999378004758 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 999378004759 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 999378004760 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 999378004761 RimM N-terminal domain; Region: RimM; pfam01782 999378004762 PRC-barrel domain; Region: PRC; pfam05239 999378004763 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 999378004764 KH domain; Region: KH_4; pfam13083 999378004765 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 999378004766 signal recognition particle protein; Provisional; Region: PRK10867 999378004767 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 999378004768 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 999378004769 P loop; other site 999378004770 GTP binding site [chemical binding]; other site 999378004771 Signal peptide binding domain; Region: SRP_SPB; pfam02978 999378004772 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 999378004773 putative DNA-binding protein; Validated; Region: PRK00118 999378004774 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 999378004775 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 999378004776 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 999378004777 P loop; other site 999378004778 GTP binding site [chemical binding]; other site 999378004779 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 999378004780 AAA domain; Region: AAA_23; pfam13476 999378004781 Walker A/P-loop; other site 999378004782 ATP binding site [chemical binding]; other site 999378004783 Q-loop/lid; other site 999378004784 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 999378004785 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 999378004786 ABC transporter signature motif; other site 999378004787 Walker B; other site 999378004788 D-loop; other site 999378004789 H-loop/switch region; other site 999378004790 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 999378004791 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 999378004792 dimerization interface [polypeptide binding]; other site 999378004793 active site 999378004794 metal binding site [ion binding]; metal-binding site 999378004795 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 999378004796 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 999378004797 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 999378004798 peptide binding site [polypeptide binding]; other site 999378004799 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 999378004800 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 999378004801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378004802 dimer interface [polypeptide binding]; other site 999378004803 conserved gate region; other site 999378004804 putative PBP binding loops; other site 999378004805 ABC-ATPase subunit interface; other site 999378004806 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 999378004807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378004808 dimer interface [polypeptide binding]; other site 999378004809 conserved gate region; other site 999378004810 putative PBP binding loops; other site 999378004811 ABC-ATPase subunit interface; other site 999378004812 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 999378004813 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 999378004814 Walker A/P-loop; other site 999378004815 ATP binding site [chemical binding]; other site 999378004816 Q-loop/lid; other site 999378004817 ABC transporter signature motif; other site 999378004818 Walker B; other site 999378004819 D-loop; other site 999378004820 H-loop/switch region; other site 999378004821 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 999378004822 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 999378004823 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 999378004824 Walker A/P-loop; other site 999378004825 ATP binding site [chemical binding]; other site 999378004826 Q-loop/lid; other site 999378004827 ABC transporter signature motif; other site 999378004828 Walker B; other site 999378004829 D-loop; other site 999378004830 H-loop/switch region; other site 999378004831 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 999378004832 acyl carrier protein; Provisional; Region: acpP; PRK00982 999378004833 putative phosphate acyltransferase; Provisional; Region: PRK05331 999378004834 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 999378004835 Y-family of DNA polymerases; Region: PolY; cl12025 999378004836 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 999378004837 generic binding surface II; other site 999378004838 ssDNA binding site; other site 999378004839 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 999378004840 ATP binding site [chemical binding]; other site 999378004841 putative Mg++ binding site [ion binding]; other site 999378004842 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 999378004843 nucleotide binding region [chemical binding]; other site 999378004844 ATP-binding site [chemical binding]; other site 999378004845 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 999378004846 DAK2 domain; Region: Dak2; pfam02734 999378004847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 999378004848 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 999378004849 Thiamine pyrophosphokinase; Region: TPK; cd07995 999378004850 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 999378004851 active site 999378004852 dimerization interface [polypeptide binding]; other site 999378004853 thiamine binding site [chemical binding]; other site 999378004854 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 999378004855 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 999378004856 substrate binding site [chemical binding]; other site 999378004857 hexamer interface [polypeptide binding]; other site 999378004858 metal binding site [ion binding]; metal-binding site 999378004859 GTPase RsgA; Reviewed; Region: PRK00098 999378004860 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 999378004861 RNA binding site [nucleotide binding]; other site 999378004862 homodimer interface [polypeptide binding]; other site 999378004863 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 999378004864 GTPase/Zn-binding domain interface [polypeptide binding]; other site 999378004865 GTP/Mg2+ binding site [chemical binding]; other site 999378004866 G4 box; other site 999378004867 G5 box; other site 999378004868 G1 box; other site 999378004869 Switch I region; other site 999378004870 G2 box; other site 999378004871 G3 box; other site 999378004872 Switch II region; other site 999378004873 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 999378004874 Catalytic domain of Protein Kinases; Region: PKc; cd00180 999378004875 active site 999378004876 ATP binding site [chemical binding]; other site 999378004877 substrate binding site [chemical binding]; other site 999378004878 activation loop (A-loop); other site 999378004879 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 999378004880 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 999378004881 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 999378004882 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 999378004883 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 999378004884 active site 999378004885 16S rRNA methyltransferase B; Provisional; Region: PRK14902 999378004886 NusB family; Region: NusB; pfam01029 999378004887 putative RNA binding site [nucleotide binding]; other site 999378004888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999378004889 S-adenosylmethionine binding site [chemical binding]; other site 999378004890 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 999378004891 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 999378004892 putative active site [active] 999378004893 substrate binding site [chemical binding]; other site 999378004894 putative cosubstrate binding site; other site 999378004895 catalytic site [active] 999378004896 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 999378004897 substrate binding site [chemical binding]; other site 999378004898 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 999378004899 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 999378004900 ATP binding site [chemical binding]; other site 999378004901 putative Mg++ binding site [ion binding]; other site 999378004902 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 999378004903 nucleotide binding region [chemical binding]; other site 999378004904 ATP-binding site [chemical binding]; other site 999378004905 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 999378004906 Flavoprotein; Region: Flavoprotein; pfam02441 999378004907 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 999378004908 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 999378004909 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 999378004910 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 999378004911 catalytic site [active] 999378004912 G-X2-G-X-G-K; other site 999378004913 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 999378004914 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 999378004915 nucleophile elbow; other site 999378004916 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 999378004917 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 999378004918 Walker A/P-loop; other site 999378004919 ATP binding site [chemical binding]; other site 999378004920 Q-loop/lid; other site 999378004921 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 999378004922 ABC transporter signature motif; other site 999378004923 Walker B; other site 999378004924 D-loop; other site 999378004925 H-loop/switch region; other site 999378004926 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 999378004927 arginine repressor; Provisional; Region: PRK04280 999378004928 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 999378004929 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 999378004930 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 999378004931 RNA binding surface [nucleotide binding]; other site 999378004932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999378004933 S-adenosylmethionine binding site [chemical binding]; other site 999378004934 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 999378004935 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 999378004936 substrate binding pocket [chemical binding]; other site 999378004937 chain length determination region; other site 999378004938 substrate-Mg2+ binding site; other site 999378004939 catalytic residues [active] 999378004940 aspartate-rich region 1; other site 999378004941 active site lid residues [active] 999378004942 aspartate-rich region 2; other site 999378004943 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 999378004944 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 999378004945 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 999378004946 generic binding surface II; other site 999378004947 generic binding surface I; other site 999378004948 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14169 999378004949 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 999378004950 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 999378004951 homodimer interface [polypeptide binding]; other site 999378004952 NADP binding site [chemical binding]; other site 999378004953 substrate binding site [chemical binding]; other site 999378004954 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 999378004955 putative RNA binding site [nucleotide binding]; other site 999378004956 Asp23 family; Region: Asp23; pfam03780 999378004957 elongation factor P; Validated; Region: PRK00529 999378004958 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 999378004959 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 999378004960 RNA binding site [nucleotide binding]; other site 999378004961 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 999378004962 RNA binding site [nucleotide binding]; other site 999378004963 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 999378004964 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 999378004965 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 999378004966 active site 999378004967 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 999378004968 Protein of unknown function (DUF464); Region: DUF464; pfam04327 999378004969 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 999378004970 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 999378004971 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 999378004972 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 999378004973 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 999378004974 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 999378004975 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 999378004976 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 999378004977 DNA binding residues [nucleotide binding] 999378004978 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 999378004979 putative dimer interface [polypeptide binding]; other site 999378004980 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 999378004981 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 999378004982 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 999378004983 catalytic residue [active] 999378004984 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 999378004985 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 999378004986 Aluminium resistance protein; Region: Alum_res; pfam06838 999378004987 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 999378004988 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 999378004989 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 999378004990 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 999378004991 active site residue [active] 999378004992 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 999378004993 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 999378004994 nucleotide binding site [chemical binding]; other site 999378004995 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 999378004996 Rhomboid family; Region: Rhomboid; pfam01694 999378004997 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 999378004998 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 999378004999 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 999378005000 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 999378005001 Helix-turn-helix domain; Region: HTH_38; pfam13936 999378005002 Integrase core domain; Region: rve; pfam00665 999378005003 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 999378005004 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 999378005005 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 999378005006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999378005007 active site 999378005008 phosphorylation site [posttranslational modification] 999378005009 intermolecular recognition site; other site 999378005010 dimerization interface [polypeptide binding]; other site 999378005011 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 999378005012 DNA binding residues [nucleotide binding] 999378005013 dimerization interface [polypeptide binding]; other site 999378005014 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 999378005015 Histidine kinase; Region: HisKA_3; pfam07730 999378005016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999378005017 ATP binding site [chemical binding]; other site 999378005018 Mg2+ binding site [ion binding]; other site 999378005019 G-X-G motif; other site 999378005020 Predicted membrane protein [Function unknown]; Region: COG4758 999378005021 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 999378005022 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 999378005023 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 999378005024 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 999378005025 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 999378005026 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 999378005027 ATP-binding site [chemical binding]; other site 999378005028 Sugar specificity; other site 999378005029 Pyrimidine base specificity; other site 999378005030 YceG-like family; Region: YceG; pfam02618 999378005031 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 999378005032 dimerization interface [polypeptide binding]; other site 999378005033 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 999378005034 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 999378005035 putative tRNA-binding site [nucleotide binding]; other site 999378005036 B3/4 domain; Region: B3_4; pfam03483 999378005037 tRNA synthetase B5 domain; Region: B5; smart00874 999378005038 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 999378005039 dimer interface [polypeptide binding]; other site 999378005040 motif 1; other site 999378005041 motif 3; other site 999378005042 motif 2; other site 999378005043 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 999378005044 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 999378005045 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 999378005046 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 999378005047 dimer interface [polypeptide binding]; other site 999378005048 motif 1; other site 999378005049 active site 999378005050 motif 2; other site 999378005051 motif 3; other site 999378005052 Predicted transcriptional regulators [Transcription]; Region: COG1733 999378005053 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 999378005054 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 999378005055 Zn2+ binding site [ion binding]; other site 999378005056 Mg2+ binding site [ion binding]; other site 999378005057 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 999378005058 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 999378005059 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 999378005060 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 999378005061 OxaA-like protein precursor; Provisional; Region: PRK02463 999378005062 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 999378005063 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 999378005064 HAMP domain; Region: HAMP; pfam00672 999378005065 dimerization interface [polypeptide binding]; other site 999378005066 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 999378005067 dimer interface [polypeptide binding]; other site 999378005068 phosphorylation site [posttranslational modification] 999378005069 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999378005070 ATP binding site [chemical binding]; other site 999378005071 Mg2+ binding site [ion binding]; other site 999378005072 G-X-G motif; other site 999378005073 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 999378005074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999378005075 active site 999378005076 phosphorylation site [posttranslational modification] 999378005077 intermolecular recognition site; other site 999378005078 dimerization interface [polypeptide binding]; other site 999378005079 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 999378005080 DNA binding site [nucleotide binding] 999378005081 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 999378005082 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 999378005083 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 999378005084 Protein of unknown function (DUF3781); Region: DUF3781; pfam12636 999378005085 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 999378005086 hypothetical protein; Provisional; Region: PRK13670 999378005087 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 999378005088 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 999378005089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999378005090 S-adenosylmethionine binding site [chemical binding]; other site 999378005091 Oligomerisation domain; Region: Oligomerisation; pfam02410 999378005092 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 999378005093 Zn2+ binding site [ion binding]; other site 999378005094 Mg2+ binding site [ion binding]; other site 999378005095 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 999378005096 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 999378005097 active site 999378005098 (T/H)XGH motif; other site 999378005099 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 999378005100 GTPase YqeH; Provisional; Region: PRK13796 999378005101 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 999378005102 GTP/Mg2+ binding site [chemical binding]; other site 999378005103 G4 box; other site 999378005104 G5 box; other site 999378005105 G1 box; other site 999378005106 Switch I region; other site 999378005107 G2 box; other site 999378005108 G3 box; other site 999378005109 Switch II region; other site 999378005110 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 999378005111 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378005112 active site 999378005113 motif I; other site 999378005114 motif II; other site 999378005115 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 999378005116 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 999378005117 Zn binding site [ion binding]; other site 999378005118 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 999378005119 Zn binding site [ion binding]; other site 999378005120 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 999378005121 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 999378005122 Zn binding site [ion binding]; other site 999378005123 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 999378005124 Zn binding site [ion binding]; other site 999378005125 Predicted esterase [General function prediction only]; Region: COG0400 999378005126 putative hydrolase; Provisional; Region: PRK11460 999378005127 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 999378005128 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 999378005129 putative NAD(P) binding site [chemical binding]; other site 999378005130 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 999378005131 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 999378005132 23S rRNA binding site [nucleotide binding]; other site 999378005133 L21 binding site [polypeptide binding]; other site 999378005134 L13 binding site [polypeptide binding]; other site 999378005135 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 999378005136 translation initiation factor IF-3; Region: infC; TIGR00168 999378005137 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 999378005138 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 999378005139 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 999378005140 catalytic core [active] 999378005141 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 999378005142 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 999378005143 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 999378005144 active site 999378005145 dimer interface [polypeptide binding]; other site 999378005146 motif 1; other site 999378005147 motif 2; other site 999378005148 motif 3; other site 999378005149 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 999378005150 anticodon binding site; other site 999378005151 primosomal protein DnaI; Reviewed; Region: PRK08939 999378005152 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 999378005153 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999378005154 Walker A motif; other site 999378005155 ATP binding site [chemical binding]; other site 999378005156 Walker B motif; other site 999378005157 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 999378005158 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 999378005159 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 999378005160 ATP cone domain; Region: ATP-cone; pfam03477 999378005161 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 999378005162 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 999378005163 CoA-binding site [chemical binding]; other site 999378005164 ATP-binding [chemical binding]; other site 999378005165 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 999378005166 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 999378005167 DNA binding site [nucleotide binding] 999378005168 catalytic residue [active] 999378005169 H2TH interface [polypeptide binding]; other site 999378005170 putative catalytic residues [active] 999378005171 turnover-facilitating residue; other site 999378005172 intercalation triad [nucleotide binding]; other site 999378005173 8OG recognition residue [nucleotide binding]; other site 999378005174 putative reading head residues; other site 999378005175 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 999378005176 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 999378005177 DNA polymerase I; Provisional; Region: PRK05755 999378005178 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 999378005179 active site 999378005180 metal binding site 1 [ion binding]; metal-binding site 999378005181 putative 5' ssDNA interaction site; other site 999378005182 metal binding site 3; metal-binding site 999378005183 metal binding site 2 [ion binding]; metal-binding site 999378005184 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 999378005185 putative DNA binding site [nucleotide binding]; other site 999378005186 putative metal binding site [ion binding]; other site 999378005187 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 999378005188 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 999378005189 active site 999378005190 DNA binding site [nucleotide binding] 999378005191 catalytic site [active] 999378005192 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 999378005193 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 999378005194 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 999378005195 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 999378005196 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 999378005197 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 999378005198 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 999378005199 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 999378005200 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 999378005201 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 999378005202 putative tRNA-binding site [nucleotide binding]; other site 999378005203 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 999378005204 catalytic residues [active] 999378005205 Predicted small secreted protein [Function unknown]; Region: COG5584 999378005206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999378005207 S-adenosylmethionine binding site [chemical binding]; other site 999378005208 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 999378005209 Phosphotransferase enzyme family; Region: APH; pfam01636 999378005210 substrate binding site [chemical binding]; other site 999378005211 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 999378005212 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 999378005213 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 999378005214 Walker A/P-loop; other site 999378005215 ATP binding site [chemical binding]; other site 999378005216 Q-loop/lid; other site 999378005217 ABC transporter signature motif; other site 999378005218 Walker B; other site 999378005219 D-loop; other site 999378005220 H-loop/switch region; other site 999378005221 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 999378005222 HIT family signature motif; other site 999378005223 catalytic residue [active] 999378005224 YtxH-like protein; Region: YtxH; pfam12732 999378005225 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 999378005226 SurA N-terminal domain; Region: SurA_N_3; cl07813 999378005227 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 999378005228 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 999378005229 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 999378005230 generic binding surface I; other site 999378005231 generic binding surface II; other site 999378005232 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 999378005233 Zn2+ binding site [ion binding]; other site 999378005234 Mg2+ binding site [ion binding]; other site 999378005235 Protein of unknown function (DUF964); Region: DUF964; cl01483 999378005236 Transglycosylase; Region: Transgly; pfam00912 999378005237 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 999378005238 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 999378005239 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 999378005240 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 999378005241 active site 999378005242 Arginine repressor [Transcription]; Region: ArgR; COG1438 999378005243 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 999378005244 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 999378005245 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 999378005246 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 999378005247 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 999378005248 active site 999378005249 HIGH motif; other site 999378005250 KMSK motif region; other site 999378005251 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 999378005252 tRNA binding surface [nucleotide binding]; other site 999378005253 anticodon binding site; other site 999378005254 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 999378005255 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 999378005256 active site 999378005257 FMN binding site [chemical binding]; other site 999378005258 substrate binding site [chemical binding]; other site 999378005259 catalytic residues [active] 999378005260 homodimer interface [polypeptide binding]; other site 999378005261 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 999378005262 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 999378005263 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 999378005264 putative active site [active] 999378005265 catalytic site [active] 999378005266 putative metal binding site [ion binding]; other site 999378005267 adaptor protein; Provisional; Region: PRK02315 999378005268 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 999378005269 ArsC family; Region: ArsC; pfam03960 999378005270 putative catalytic residues [active] 999378005271 thiol/disulfide switch; other site 999378005272 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 999378005273 FtsX-like permease family; Region: FtsX; pfam02687 999378005274 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 999378005275 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 999378005276 Walker A/P-loop; other site 999378005277 ATP binding site [chemical binding]; other site 999378005278 Q-loop/lid; other site 999378005279 ABC transporter signature motif; other site 999378005280 Walker B; other site 999378005281 D-loop; other site 999378005282 H-loop/switch region; other site 999378005283 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 999378005284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999378005285 active site 999378005286 phosphorylation site [posttranslational modification] 999378005287 intermolecular recognition site; other site 999378005288 dimerization interface [polypeptide binding]; other site 999378005289 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 999378005290 DNA binding site [nucleotide binding] 999378005291 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 999378005292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999378005293 ATP binding site [chemical binding]; other site 999378005294 Mg2+ binding site [ion binding]; other site 999378005295 G-X-G motif; other site 999378005296 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 999378005297 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 999378005298 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 999378005299 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 999378005300 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 999378005301 Penicillinase repressor; Region: Pencillinase_R; pfam03965 999378005302 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 999378005303 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 999378005304 ATP-grasp domain; Region: ATP-grasp_4; cl17255 999378005305 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 999378005306 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 999378005307 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 999378005308 purine monophosphate binding site [chemical binding]; other site 999378005309 dimer interface [polypeptide binding]; other site 999378005310 putative catalytic residues [active] 999378005311 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 999378005312 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 999378005313 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 999378005314 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 999378005315 active site 999378005316 substrate binding site [chemical binding]; other site 999378005317 cosubstrate binding site; other site 999378005318 catalytic site [active] 999378005319 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 999378005320 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 999378005321 dimerization interface [polypeptide binding]; other site 999378005322 putative ATP binding site [chemical binding]; other site 999378005323 amidophosphoribosyltransferase; Provisional; Region: PRK07272 999378005324 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 999378005325 active site 999378005326 tetramer interface [polypeptide binding]; other site 999378005327 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 999378005328 active site 999378005329 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 999378005330 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 999378005331 dimerization interface [polypeptide binding]; other site 999378005332 ATP binding site [chemical binding]; other site 999378005333 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 999378005334 dimerization interface [polypeptide binding]; other site 999378005335 ATP binding site [chemical binding]; other site 999378005336 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 999378005337 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 999378005338 putative active site [active] 999378005339 catalytic triad [active] 999378005340 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 999378005341 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 999378005342 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 999378005343 ATP binding site [chemical binding]; other site 999378005344 active site 999378005345 substrate binding site [chemical binding]; other site 999378005346 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 999378005347 ATP-grasp domain; Region: ATP-grasp; pfam02222 999378005348 AIR carboxylase; Region: AIRC; pfam00731 999378005349 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 999378005350 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 999378005351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378005352 putative substrate translocation pore; other site 999378005353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378005354 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 999378005355 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 999378005356 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 999378005357 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 999378005358 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 999378005359 dimerization domain swap beta strand [polypeptide binding]; other site 999378005360 regulatory protein interface [polypeptide binding]; other site 999378005361 active site 999378005362 regulatory phosphorylation site [posttranslational modification]; other site 999378005363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999378005364 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 999378005365 Walker A motif; other site 999378005366 ATP binding site [chemical binding]; other site 999378005367 Walker B motif; other site 999378005368 arginine finger; other site 999378005369 UvrB/uvrC motif; Region: UVR; pfam02151 999378005370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999378005371 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 999378005372 Walker A motif; other site 999378005373 ATP binding site [chemical binding]; other site 999378005374 Walker B motif; other site 999378005375 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 999378005376 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 999378005377 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 999378005378 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 999378005379 G1 box; other site 999378005380 putative GEF interaction site [polypeptide binding]; other site 999378005381 GTP/Mg2+ binding site [chemical binding]; other site 999378005382 Switch I region; other site 999378005383 G2 box; other site 999378005384 G3 box; other site 999378005385 Switch II region; other site 999378005386 G4 box; other site 999378005387 G5 box; other site 999378005388 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 999378005389 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 999378005390 Domain of unknown function DUF21; Region: DUF21; pfam01595 999378005391 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 999378005392 Transporter associated domain; Region: CorC_HlyC; pfam03471 999378005393 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 999378005394 Domain of unknown function DUF20; Region: UPF0118; pfam01594 999378005395 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999378005396 Coenzyme A binding pocket [chemical binding]; other site 999378005397 hypothetical protein; Provisional; Region: PRK13662 999378005398 RecX family; Region: RecX; cl00936 999378005399 Mga helix-turn-helix domain; Region: Mga; pfam05043 999378005400 TRAM domain; Region: TRAM; pfam01938 999378005401 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 999378005402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999378005403 S-adenosylmethionine binding site [chemical binding]; other site 999378005404 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 999378005405 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 999378005406 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999378005407 DNA-binding site [nucleotide binding]; DNA binding site 999378005408 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 999378005409 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 999378005410 beta-galactosidase; Region: BGL; TIGR03356 999378005411 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 999378005412 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 999378005413 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 999378005414 active site 999378005415 methionine cluster; other site 999378005416 phosphorylation site [posttranslational modification] 999378005417 metal binding site [ion binding]; metal-binding site 999378005418 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 999378005419 active site 999378005420 P-loop; other site 999378005421 phosphorylation site [posttranslational modification] 999378005422 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 999378005423 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 999378005424 PYR/PP interface [polypeptide binding]; other site 999378005425 dimer interface [polypeptide binding]; other site 999378005426 tetramer interface [polypeptide binding]; other site 999378005427 TPP binding site [chemical binding]; other site 999378005428 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 999378005429 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 999378005430 TPP-binding site [chemical binding]; other site 999378005431 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 999378005432 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 999378005433 dimer interface [polypeptide binding]; other site 999378005434 active site 999378005435 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 999378005436 homodimer interface [polypeptide binding]; other site 999378005437 catalytic residues [active] 999378005438 NAD binding site [chemical binding]; other site 999378005439 substrate binding pocket [chemical binding]; other site 999378005440 flexible flap; other site 999378005441 putative acyltransferase; Provisional; Region: PRK05790 999378005442 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 999378005443 dimer interface [polypeptide binding]; other site 999378005444 active site 999378005445 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 999378005446 Restriction endonuclease; Region: Mrr_cat; pfam04471 999378005447 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 999378005448 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 999378005449 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 999378005450 metal binding site [ion binding]; metal-binding site 999378005451 dimer interface [polypeptide binding]; other site 999378005452 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 999378005453 Predicted membrane protein [Function unknown]; Region: COG4684 999378005454 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 999378005455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999378005456 Coenzyme A binding pocket [chemical binding]; other site 999378005457 hypothetical protein; Provisional; Region: PRK04351 999378005458 SprT homologues; Region: SprT; cl01182 999378005459 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 999378005460 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378005461 Walker A/P-loop; other site 999378005462 ATP binding site [chemical binding]; other site 999378005463 Q-loop/lid; other site 999378005464 ABC transporter signature motif; other site 999378005465 Walker B; other site 999378005466 D-loop; other site 999378005467 H-loop/switch region; other site 999378005468 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 999378005469 TM-ABC transporter signature motif; other site 999378005470 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 999378005471 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 999378005472 zinc binding site [ion binding]; other site 999378005473 putative ligand binding site [chemical binding]; other site 999378005474 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 999378005475 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 999378005476 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 999378005477 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 999378005478 Soluble P-type ATPase [General function prediction only]; Region: COG4087 999378005479 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 999378005480 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 999378005481 Beta-lactamase; Region: Beta-lactamase; pfam00144 999378005482 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 999378005483 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 999378005484 homodimer interface [polypeptide binding]; other site 999378005485 NAD binding pocket [chemical binding]; other site 999378005486 ATP binding pocket [chemical binding]; other site 999378005487 Mg binding site [ion binding]; other site 999378005488 active-site loop [active] 999378005489 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 999378005490 Beta-lactamase; Region: Beta-lactamase; pfam00144 999378005491 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 999378005492 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 999378005493 active site 999378005494 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 999378005495 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999378005496 DNA-binding site [nucleotide binding]; DNA binding site 999378005497 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 999378005498 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 999378005499 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 999378005500 active site 999378005501 dimer interface [polypeptide binding]; other site 999378005502 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 999378005503 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 999378005504 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 999378005505 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 999378005506 putative phosphoesterase; Region: acc_ester; TIGR03729 999378005507 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 999378005508 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 999378005509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378005510 putative substrate translocation pore; other site 999378005511 POT family; Region: PTR2; pfam00854 999378005512 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 999378005513 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 999378005514 Walker A/P-loop; other site 999378005515 ATP binding site [chemical binding]; other site 999378005516 Q-loop/lid; other site 999378005517 ABC transporter signature motif; other site 999378005518 Walker B; other site 999378005519 D-loop; other site 999378005520 H-loop/switch region; other site 999378005521 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 999378005522 FtsX-like permease family; Region: FtsX; pfam02687 999378005523 MFS/sugar transport protein; Region: MFS_2; pfam13347 999378005524 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 999378005525 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 999378005526 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 999378005527 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 999378005528 catalytic residues [active] 999378005529 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 999378005530 active site 999378005531 nucleotide-binding site [chemical binding]; other site 999378005532 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 999378005533 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 999378005534 G1 box; other site 999378005535 GTP/Mg2+ binding site [chemical binding]; other site 999378005536 Switch I region; other site 999378005537 G2 box; other site 999378005538 G3 box; other site 999378005539 Switch II region; other site 999378005540 G4 box; other site 999378005541 G5 box; other site 999378005542 Nucleoside recognition; Region: Gate; pfam07670 999378005543 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 999378005544 Nucleoside recognition; Region: Gate; pfam07670 999378005545 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 999378005546 FeoA domain; Region: FeoA; cl00838 999378005547 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 999378005548 catalytic triad [active] 999378005549 catalytic triad [active] 999378005550 oxyanion hole [active] 999378005551 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 999378005552 NADH(P)-binding; Region: NAD_binding_10; pfam13460 999378005553 NAD binding site [chemical binding]; other site 999378005554 substrate binding site [chemical binding]; other site 999378005555 putative active site [active] 999378005556 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 999378005557 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 999378005558 Domain of unknown function (DUF4323); Region: DUF4323; pfam14211 999378005559 seryl-tRNA synthetase; Provisional; Region: PRK05431 999378005560 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 999378005561 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 999378005562 dimer interface [polypeptide binding]; other site 999378005563 active site 999378005564 motif 1; other site 999378005565 motif 2; other site 999378005566 motif 3; other site 999378005567 Mga helix-turn-helix domain; Region: Mga; pfam05043 999378005568 Mga helix-turn-helix domain; Region: Mga; pfam05043 999378005569 lysine transporter; Provisional; Region: PRK10836 999378005570 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 999378005571 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 999378005572 acetolactate synthase; Reviewed; Region: PRK08617 999378005573 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 999378005574 PYR/PP interface [polypeptide binding]; other site 999378005575 dimer interface [polypeptide binding]; other site 999378005576 TPP binding site [chemical binding]; other site 999378005577 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 999378005578 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 999378005579 TPP-binding site [chemical binding]; other site 999378005580 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 999378005581 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 999378005582 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 999378005583 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 999378005584 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 999378005585 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 999378005586 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 999378005587 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 999378005588 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 999378005589 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 999378005590 active site 999378005591 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 999378005592 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 999378005593 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 999378005594 Transcriptional regulators [Transcription]; Region: GntR; COG1802 999378005595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999378005596 DNA-binding site [nucleotide binding]; DNA binding site 999378005597 FCD domain; Region: FCD; pfam07729 999378005598 oxaloacetate decarboxylase; Provisional; Region: PRK12331 999378005599 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 999378005600 active site 999378005601 catalytic residues [active] 999378005602 metal binding site [ion binding]; metal-binding site 999378005603 homodimer binding site [polypeptide binding]; other site 999378005604 2'-(5''-triphosphoribosyl)-3'- dephospho-CoA:apo-citrate lyase; Reviewed; Region: citX; PRK01392 999378005605 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 999378005606 Coenzyme A transferase; Region: CoA_trans; cl17247 999378005607 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 999378005608 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 999378005609 citrate lyase subunit gamma; Provisional; Region: PRK13253 999378005610 [citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124 999378005611 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 999378005612 active site 999378005613 nucleotide binding site [chemical binding]; other site 999378005614 HIGH motif; other site 999378005615 KMSKS motif; other site 999378005616 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 999378005617 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 999378005618 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 999378005619 carboxyltransferase (CT) interaction site; other site 999378005620 biotinylation site [posttranslational modification]; other site 999378005621 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 999378005622 Citrate transporter; Region: CitMHS; pfam03600 999378005623 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 999378005624 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885 999378005625 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 999378005626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999378005627 Coenzyme A binding pocket [chemical binding]; other site 999378005628 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 999378005629 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 999378005630 Predicted transcriptional regulators [Transcription]; Region: COG1695 999378005631 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 999378005632 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 999378005633 dimer interface [polypeptide binding]; other site 999378005634 FMN binding site [chemical binding]; other site 999378005635 NADPH bind site [chemical binding]; other site 999378005636 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 999378005637 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 999378005638 Walker A/P-loop; other site 999378005639 ATP binding site [chemical binding]; other site 999378005640 Q-loop/lid; other site 999378005641 ABC transporter signature motif; other site 999378005642 Walker B; other site 999378005643 D-loop; other site 999378005644 H-loop/switch region; other site 999378005645 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 999378005646 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999378005647 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999378005648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378005649 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999378005650 putative substrate translocation pore; other site 999378005651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378005652 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 999378005653 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999378005654 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999378005655 non-specific DNA binding site [nucleotide binding]; other site 999378005656 salt bridge; other site 999378005657 sequence-specific DNA binding site [nucleotide binding]; other site 999378005658 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 999378005659 Predicted transcriptional regulators [Transcription]; Region: COG1725 999378005660 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999378005661 DNA-binding site [nucleotide binding]; DNA binding site 999378005662 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 999378005663 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378005664 Walker A/P-loop; other site 999378005665 ATP binding site [chemical binding]; other site 999378005666 Q-loop/lid; other site 999378005667 ABC transporter signature motif; other site 999378005668 Walker B; other site 999378005669 D-loop; other site 999378005670 H-loop/switch region; other site 999378005671 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 999378005672 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 999378005673 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 999378005674 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 999378005675 Walker A/P-loop; other site 999378005676 ATP binding site [chemical binding]; other site 999378005677 Q-loop/lid; other site 999378005678 ABC transporter signature motif; other site 999378005679 Walker B; other site 999378005680 D-loop; other site 999378005681 H-loop/switch region; other site 999378005682 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 999378005683 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 999378005684 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 999378005685 Walker A/P-loop; other site 999378005686 ATP binding site [chemical binding]; other site 999378005687 Q-loop/lid; other site 999378005688 ABC transporter signature motif; other site 999378005689 Walker B; other site 999378005690 D-loop; other site 999378005691 H-loop/switch region; other site 999378005692 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 999378005693 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 999378005694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378005695 dimer interface [polypeptide binding]; other site 999378005696 conserved gate region; other site 999378005697 putative PBP binding loops; other site 999378005698 ABC-ATPase subunit interface; other site 999378005699 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 999378005700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378005701 dimer interface [polypeptide binding]; other site 999378005702 conserved gate region; other site 999378005703 putative PBP binding loops; other site 999378005704 ABC-ATPase subunit interface; other site 999378005705 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 999378005706 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 999378005707 peptide binding site [polypeptide binding]; other site 999378005708 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 999378005709 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 999378005710 potential catalytic triad [active] 999378005711 conserved cys residue [active] 999378005712 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999378005713 putative DNA binding site [nucleotide binding]; other site 999378005714 putative Zn2+ binding site [ion binding]; other site 999378005715 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 999378005716 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999378005717 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378005718 Walker A/P-loop; other site 999378005719 ATP binding site [chemical binding]; other site 999378005720 Q-loop/lid; other site 999378005721 ABC transporter signature motif; other site 999378005722 Walker B; other site 999378005723 D-loop; other site 999378005724 H-loop/switch region; other site 999378005725 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 999378005726 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999378005727 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 999378005728 Walker A/P-loop; other site 999378005729 ATP binding site [chemical binding]; other site 999378005730 Q-loop/lid; other site 999378005731 ABC transporter signature motif; other site 999378005732 Walker B; other site 999378005733 D-loop; other site 999378005734 H-loop/switch region; other site 999378005735 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 999378005736 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999378005737 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 999378005738 active site 999378005739 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 999378005740 Helix-turn-helix domain; Region: HTH_38; pfam13936 999378005741 Integrase core domain; Region: rve; pfam00665 999378005742 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 999378005743 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 999378005744 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 999378005745 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 999378005746 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999378005747 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999378005748 non-specific DNA binding site [nucleotide binding]; other site 999378005749 salt bridge; other site 999378005750 sequence-specific DNA binding site [nucleotide binding]; other site 999378005751 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 999378005752 Homeodomain-like domain; Region: HTH_23; cl17451 999378005753 Transposase; Region: DDE_Tnp_ISL3; pfam01610 999378005754 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 999378005755 Transposase; Region: DDE_Tnp_ISL3; pfam01610 999378005756 Integrase core domain; Region: rve; pfam00665 999378005757 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 999378005758 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 999378005759 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 999378005760 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 999378005761 Helix-turn-helix domain; Region: HTH_38; pfam13936 999378005762 Integrase core domain; Region: rve; pfam00665 999378005763 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 999378005764 Transposase; Region: HTH_Tnp_1; pfam01527 999378005765 HTH-like domain; Region: HTH_21; pfam13276 999378005766 Integrase core domain; Region: rve; pfam00665 999378005767 Integrase core domain; Region: rve_3; pfam13683 999378005768 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 999378005769 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 999378005770 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 999378005771 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 999378005772 Cl binding site [ion binding]; other site 999378005773 oligomer interface [polypeptide binding]; other site 999378005774 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 999378005775 Helix-turn-helix domain; Region: HTH_38; pfam13936 999378005776 Integrase core domain; Region: rve; pfam00665 999378005777 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 999378005778 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 999378005779 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_2; cd08769 999378005780 SxDxEG motif; other site 999378005781 putative active site [active] 999378005782 putative metal binding site [ion binding]; other site 999378005783 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 999378005784 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 999378005785 oligomer interface [polypeptide binding]; other site 999378005786 active site 999378005787 metal binding site [ion binding]; metal-binding site 999378005788 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 999378005789 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 999378005790 peptide binding site [polypeptide binding]; other site 999378005791 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 999378005792 Integrase core domain; Region: rve; pfam00665 999378005793 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 999378005794 Helix-turn-helix domain; Region: HTH_16; pfam12645 999378005795 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 999378005796 PAZ domain, named PAZ after the proteins Piwi Argonaut and Zwille. PAZ is found in two families of proteins that are essential components of RNA-mediated gene-silencing pathways, including RNA interference, the piwi and Dicer families. PAZ functions as a...; Region: PAZ; cl00301 999378005797 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 999378005798 nucleic acid-binding interface [nucleotide binding]; other site 999378005799 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 999378005800 Int/Topo IB signature motif; other site 999378005801 GMP synthase; Reviewed; Region: guaA; PRK00074 999378005802 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 999378005803 AMP/PPi binding site [chemical binding]; other site 999378005804 candidate oxyanion hole; other site 999378005805 catalytic triad [active] 999378005806 potential glutamine specificity residues [chemical binding]; other site 999378005807 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 999378005808 ATP Binding subdomain [chemical binding]; other site 999378005809 Dimerization subdomain; other site 999378005810 pantothenate kinase; Provisional; Region: PRK05439 999378005811 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 999378005812 ATP-binding site [chemical binding]; other site 999378005813 CoA-binding site [chemical binding]; other site 999378005814 Mg2+-binding site [ion binding]; other site 999378005815 Peptidase family C69; Region: Peptidase_C69; pfam03577 999378005816 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 999378005817 manganese transport protein MntH; Reviewed; Region: PRK00701 999378005818 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 999378005819 Ferrochelatase; Region: Ferrochelatase; pfam00762 999378005820 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 999378005821 C-terminal domain interface [polypeptide binding]; other site 999378005822 active site 999378005823 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 999378005824 active site 999378005825 N-terminal domain interface [polypeptide binding]; other site 999378005826 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 999378005827 catalytic core [active] 999378005828 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 999378005829 FtsX-like permease family; Region: FtsX; pfam02687 999378005830 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 999378005831 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 999378005832 Walker A/P-loop; other site 999378005833 ATP binding site [chemical binding]; other site 999378005834 Q-loop/lid; other site 999378005835 ABC transporter signature motif; other site 999378005836 Walker B; other site 999378005837 D-loop; other site 999378005838 H-loop/switch region; other site 999378005839 Amino acid permease; Region: AA_permease_2; pfam13520 999378005840 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 999378005841 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 999378005842 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 999378005843 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 999378005844 HflX GTPase family; Region: HflX; cd01878 999378005845 G1 box; other site 999378005846 GTP/Mg2+ binding site [chemical binding]; other site 999378005847 Switch I region; other site 999378005848 G2 box; other site 999378005849 G3 box; other site 999378005850 Switch II region; other site 999378005851 G4 box; other site 999378005852 G5 box; other site 999378005853 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 999378005854 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 999378005855 NodB motif; other site 999378005856 active site 999378005857 catalytic site [active] 999378005858 Zn binding site [ion binding]; other site 999378005859 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 999378005860 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 999378005861 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 999378005862 putative active site [active] 999378005863 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 999378005864 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 999378005865 NADP binding site [chemical binding]; other site 999378005866 active site 999378005867 putative substrate binding site [chemical binding]; other site 999378005868 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 999378005869 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 999378005870 NAD binding site [chemical binding]; other site 999378005871 substrate binding site [chemical binding]; other site 999378005872 homodimer interface [polypeptide binding]; other site 999378005873 active site 999378005874 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 999378005875 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 999378005876 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 999378005877 substrate binding site; other site 999378005878 tetramer interface; other site 999378005879 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 999378005880 Bacterial sugar transferase; Region: Bac_transf; pfam02397 999378005881 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 999378005882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 999378005883 NAD(P) binding site [chemical binding]; other site 999378005884 active site 999378005885 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 999378005886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378005887 dimer interface [polypeptide binding]; other site 999378005888 conserved gate region; other site 999378005889 putative PBP binding loops; other site 999378005890 ABC-ATPase subunit interface; other site 999378005891 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 999378005892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378005893 dimer interface [polypeptide binding]; other site 999378005894 conserved gate region; other site 999378005895 putative PBP binding loops; other site 999378005896 ABC-ATPase subunit interface; other site 999378005897 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 999378005898 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 999378005899 substrate binding pocket [chemical binding]; other site 999378005900 membrane-bound complex binding site; other site 999378005901 hinge residues; other site 999378005902 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 999378005903 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 999378005904 Walker A/P-loop; other site 999378005905 ATP binding site [chemical binding]; other site 999378005906 Q-loop/lid; other site 999378005907 ABC transporter signature motif; other site 999378005908 Walker B; other site 999378005909 D-loop; other site 999378005910 H-loop/switch region; other site 999378005911 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 999378005912 metal binding site 2 [ion binding]; metal-binding site 999378005913 putative DNA binding helix; other site 999378005914 metal binding site 1 [ion binding]; metal-binding site 999378005915 dimer interface [polypeptide binding]; other site 999378005916 structural Zn2+ binding site [ion binding]; other site 999378005917 Guanylate kinase; Region: Guanylate_kin; pfam00625 999378005918 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 999378005919 active site 999378005920 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999378005921 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 999378005922 Coenzyme A binding pocket [chemical binding]; other site 999378005923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 999378005924 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 999378005925 NlpC/P60 family; Region: NLPC_P60; pfam00877 999378005926 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 999378005927 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 999378005928 active site 999378005929 HIGH motif; other site 999378005930 dimer interface [polypeptide binding]; other site 999378005931 KMSKS motif; other site 999378005932 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 999378005933 RNA binding surface [nucleotide binding]; other site 999378005934 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 999378005935 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 999378005936 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999378005937 dimerization interface [polypeptide binding]; other site 999378005938 putative DNA binding site [nucleotide binding]; other site 999378005939 putative Zn2+ binding site [ion binding]; other site 999378005940 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 999378005941 ApbE family; Region: ApbE; pfam02424 999378005942 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 999378005943 active site 999378005944 homodimer interface [polypeptide binding]; other site 999378005945 catalytic site [active] 999378005946 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 999378005947 homodimer interface [polypeptide binding]; other site 999378005948 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 999378005949 active site pocket [active] 999378005950 glycogen synthase; Provisional; Region: glgA; PRK00654 999378005951 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 999378005952 ADP-binding pocket [chemical binding]; other site 999378005953 homodimer interface [polypeptide binding]; other site 999378005954 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 999378005955 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 999378005956 active site 999378005957 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 999378005958 dimer interface [polypeptide binding]; other site 999378005959 N-terminal domain interface [polypeptide binding]; other site 999378005960 sulfate 1 binding site; other site 999378005961 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 999378005962 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 999378005963 ligand binding site; other site 999378005964 oligomer interface; other site 999378005965 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 999378005966 dimer interface [polypeptide binding]; other site 999378005967 N-terminal domain interface [polypeptide binding]; other site 999378005968 sulfate 1 binding site; other site 999378005969 glycogen branching enzyme; Provisional; Region: PRK12313 999378005970 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 999378005971 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 999378005972 active site 999378005973 catalytic site [active] 999378005974 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 999378005975 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 999378005976 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 999378005977 homodimer interface [polypeptide binding]; other site 999378005978 substrate-cofactor binding pocket; other site 999378005979 catalytic residue [active] 999378005980 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 999378005981 Uncharacterized conserved protein [Function unknown]; Region: COG1284 999378005982 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 999378005983 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 999378005984 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 999378005985 ArsC family; Region: ArsC; pfam03960 999378005986 putative catalytic residues [active] 999378005987 thiol/disulfide switch; other site 999378005988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999378005989 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 999378005990 Walker A motif; other site 999378005991 ATP binding site [chemical binding]; other site 999378005992 Walker B motif; other site 999378005993 arginine finger; other site 999378005994 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999378005995 Walker A motif; other site 999378005996 ATP binding site [chemical binding]; other site 999378005997 Walker B motif; other site 999378005998 arginine finger; other site 999378005999 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 999378006000 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 999378006001 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 999378006002 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 999378006003 Transposase; Region: DDE_Tnp_ISL3; pfam01610 999378006004 Transposase domain (DUF772); Region: DUF772; pfam05598 999378006005 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 999378006006 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 999378006007 Homeodomain-like domain; Region: HTH_23; pfam13384 999378006008 Transposase; Region: DDE_Tnp_ISL3; pfam01610 999378006009 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 999378006010 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 999378006011 NADP binding site [chemical binding]; other site 999378006012 active site 999378006013 putative substrate binding site [chemical binding]; other site 999378006014 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 999378006015 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 999378006016 NAD binding site [chemical binding]; other site 999378006017 substrate binding site [chemical binding]; other site 999378006018 homodimer interface [polypeptide binding]; other site 999378006019 active site 999378006020 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 999378006021 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 999378006022 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 999378006023 substrate binding site; other site 999378006024 tetramer interface; other site 999378006025 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 999378006026 Bacterial sugar transferase; Region: Bac_transf; pfam02397 999378006027 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 999378006028 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 999378006029 active site 999378006030 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 999378006031 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 999378006032 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 999378006033 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 999378006034 trimer interface [polypeptide binding]; other site 999378006035 active site 999378006036 substrate binding site [chemical binding]; other site 999378006037 CoA binding site [chemical binding]; other site 999378006038 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 999378006039 active site 999378006040 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 999378006041 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 999378006042 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 999378006043 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 999378006044 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 999378006045 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 999378006046 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 999378006047 Chain length determinant protein; Region: Wzz; cl15801 999378006048 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 999378006049 catalytic triad [active] 999378006050 catalytic triad [active] 999378006051 oxyanion hole [active] 999378006052 QueT transporter; Region: QueT; pfam06177 999378006053 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 999378006054 classical (c) SDRs; Region: SDR_c; cd05233 999378006055 NAD(P) binding site [chemical binding]; other site 999378006056 active site 999378006057 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 999378006058 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999378006059 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999378006060 non-specific DNA binding site [nucleotide binding]; other site 999378006061 salt bridge; other site 999378006062 sequence-specific DNA binding site [nucleotide binding]; other site 999378006063 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 999378006064 catalytic core [active] 999378006065 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 999378006066 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 999378006067 Walker A/P-loop; other site 999378006068 ATP binding site [chemical binding]; other site 999378006069 Q-loop/lid; other site 999378006070 ABC transporter signature motif; other site 999378006071 Walker B; other site 999378006072 D-loop; other site 999378006073 H-loop/switch region; other site 999378006074 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 999378006075 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 999378006076 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 999378006077 Walker A/P-loop; other site 999378006078 ATP binding site [chemical binding]; other site 999378006079 Q-loop/lid; other site 999378006080 ABC transporter signature motif; other site 999378006081 Walker B; other site 999378006082 D-loop; other site 999378006083 H-loop/switch region; other site 999378006084 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 999378006085 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 999378006086 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 999378006087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378006088 dimer interface [polypeptide binding]; other site 999378006089 conserved gate region; other site 999378006090 putative PBP binding loops; other site 999378006091 ABC-ATPase subunit interface; other site 999378006092 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 999378006093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378006094 dimer interface [polypeptide binding]; other site 999378006095 conserved gate region; other site 999378006096 putative PBP binding loops; other site 999378006097 ABC-ATPase subunit interface; other site 999378006098 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 999378006099 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 999378006100 peptide binding site [polypeptide binding]; other site 999378006101 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 999378006102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378006103 putative substrate translocation pore; other site 999378006104 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 999378006105 Helix-turn-helix domain; Region: HTH_38; pfam13936 999378006106 Integrase core domain; Region: rve; pfam00665 999378006107 elongation factor P; Validated; Region: PRK00529 999378006108 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 999378006109 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 999378006110 RNA binding site [nucleotide binding]; other site 999378006111 Elongation factor P, C-terminal; Region: Elong-fact-P_C; pfam09285 999378006112 RNA binding site [nucleotide binding]; other site 999378006113 Uncharacterized conserved protein [Function unknown]; Region: COG1556 999378006114 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 999378006115 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 999378006116 4Fe-4S binding domain; Region: Fer4; pfam00037 999378006117 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 999378006118 Cysteine-rich domain; Region: CCG; pfam02754 999378006119 Cysteine-rich domain; Region: CCG; pfam02754 999378006120 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 999378006121 active site 999378006122 methionine cluster; other site 999378006123 phosphorylation site [posttranslational modification] 999378006124 metal binding site [ion binding]; metal-binding site 999378006125 Uncharacterized conserved protein [Function unknown]; Region: COG3589 999378006126 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 999378006127 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 999378006128 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 999378006129 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 999378006130 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 999378006131 Melibiase; Region: Melibiase; pfam02065 999378006132 hypothetical protein; Validated; Region: PRK02101 999378006133 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 999378006134 DNA binding residues [nucleotide binding] 999378006135 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 999378006136 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 999378006137 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 999378006138 AAA domain; Region: AAA_30; pfam13604 999378006139 Family description; Region: UvrD_C_2; pfam13538 999378006140 WxL domain surface cell wall-binding; Region: WxL; pfam13731 999378006141 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 999378006142 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 999378006143 substrate binding site [chemical binding]; other site 999378006144 ATP binding site [chemical binding]; other site 999378006145 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 999378006146 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 999378006147 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 999378006148 Uncharacterized conserved protein [Function unknown]; Region: COG3535 999378006149 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 999378006150 Na binding site [ion binding]; other site 999378006151 Protein of unknown function DUF262; Region: DUF262; pfam03235 999378006152 Uncharacterized conserved protein [Function unknown]; Region: COG1479 999378006153 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 999378006154 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 999378006155 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 999378006156 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 999378006157 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 999378006158 Int/Topo IB signature motif; other site 999378006159 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 999378006160 Methyltransferase domain; Region: Methyltransf_26; pfam13659 999378006161 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 999378006162 HsdM N-terminal domain; Region: HsdM_N; pfam12161 999378006163 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 999378006164 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 999378006165 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 999378006166 ATP binding site [chemical binding]; other site 999378006167 putative Mg++ binding site [ion binding]; other site 999378006168 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 999378006169 Protein of unknown function (DUF998); Region: DUF998; pfam06197 999378006170 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 999378006171 HPr interaction site; other site 999378006172 glycerol kinase (GK) interaction site [polypeptide binding]; other site 999378006173 active site 999378006174 phosphorylation site [posttranslational modification] 999378006175 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 999378006176 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 999378006177 active site turn [active] 999378006178 phosphorylation site [posttranslational modification] 999378006179 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 999378006180 Transcriptional regulators [Transcription]; Region: PurR; COG1609 999378006181 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 999378006182 DNA binding site [nucleotide binding] 999378006183 domain linker motif; other site 999378006184 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 999378006185 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 999378006186 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 999378006187 substrate binding [chemical binding]; other site 999378006188 active site 999378006189 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 999378006190 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 999378006191 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 999378006192 NADP binding site [chemical binding]; other site 999378006193 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 999378006194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999378006195 S-adenosylmethionine binding site [chemical binding]; other site 999378006196 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 999378006197 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 999378006198 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 999378006199 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 999378006200 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 999378006201 ATP-grasp domain; Region: ATP-grasp_4; cl17255 999378006202 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 999378006203 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 999378006204 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 999378006205 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 999378006206 carboxyltransferase (CT) interaction site; other site 999378006207 biotinylation site [posttranslational modification]; other site 999378006208 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 999378006209 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 999378006210 dimer interface [polypeptide binding]; other site 999378006211 active site 999378006212 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 999378006213 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 999378006214 NAD(P) binding site [chemical binding]; other site 999378006215 homotetramer interface [polypeptide binding]; other site 999378006216 homodimer interface [polypeptide binding]; other site 999378006217 active site 999378006218 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 999378006219 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 999378006220 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 999378006221 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 999378006222 FMN binding site [chemical binding]; other site 999378006223 substrate binding site [chemical binding]; other site 999378006224 putative catalytic residue [active] 999378006225 acyl carrier protein; Provisional; Region: acpP; PRK00982 999378006226 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 999378006227 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 999378006228 dimer interface [polypeptide binding]; other site 999378006229 active site 999378006230 CoA binding pocket [chemical binding]; other site 999378006231 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 999378006232 MarR family; Region: MarR_2; pfam12802 999378006233 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 999378006234 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 999378006235 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 999378006236 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 999378006237 dimer interface [polypeptide binding]; other site 999378006238 active site 999378006239 metal binding site [ion binding]; metal-binding site 999378006240 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 999378006241 Helix-turn-helix domain; Region: HTH_38; pfam13936 999378006242 Integrase core domain; Region: rve; pfam00665 999378006243 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078 999378006244 Transcriptional regulators [Transcription]; Region: MarR; COG1846 999378006245 MarR family; Region: MarR_2; pfam12802 999378006246 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 999378006247 S-formylglutathione hydrolase; Region: PLN02442 999378006248 Putative esterase; Region: Esterase; pfam00756 999378006249 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 999378006250 Double zinc ribbon; Region: DZR; pfam12773 999378006251 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999378006252 putative DNA binding site [nucleotide binding]; other site 999378006253 putative Zn2+ binding site [ion binding]; other site 999378006254 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 999378006255 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999378006256 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378006257 Walker A/P-loop; other site 999378006258 ATP binding site [chemical binding]; other site 999378006259 Q-loop/lid; other site 999378006260 ABC transporter signature motif; other site 999378006261 Walker B; other site 999378006262 D-loop; other site 999378006263 H-loop/switch region; other site 999378006264 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 999378006265 nudix motif; other site 999378006266 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 999378006267 catalytic core [active] 999378006268 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 999378006269 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 999378006270 Double zinc ribbon; Region: DZR; pfam12773 999378006271 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 999378006272 Beta-lactamase; Region: Beta-lactamase; pfam00144 999378006273 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 999378006274 Domain of unknown function DUF20; Region: UPF0118; pfam01594 999378006275 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 999378006276 active site 999378006277 catalytic site [active] 999378006278 Predicted membrane protein [Function unknown]; Region: COG2246 999378006279 GtrA-like protein; Region: GtrA; pfam04138 999378006280 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 999378006281 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 999378006282 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 999378006283 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 999378006284 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 999378006285 PYR/PP interface [polypeptide binding]; other site 999378006286 dimer interface [polypeptide binding]; other site 999378006287 TPP binding site [chemical binding]; other site 999378006288 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 999378006289 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 999378006290 TPP-binding site [chemical binding]; other site 999378006291 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 999378006292 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 999378006293 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 999378006294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378006295 dimer interface [polypeptide binding]; other site 999378006296 conserved gate region; other site 999378006297 putative PBP binding loops; other site 999378006298 ABC-ATPase subunit interface; other site 999378006299 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 999378006300 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 999378006301 Walker A/P-loop; other site 999378006302 ATP binding site [chemical binding]; other site 999378006303 Q-loop/lid; other site 999378006304 ABC transporter signature motif; other site 999378006305 Walker B; other site 999378006306 D-loop; other site 999378006307 H-loop/switch region; other site 999378006308 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 999378006309 DNA-binding protein, stimulates sugar fermentation [General function prediction only]; Region: SfsA; COG1489 999378006310 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 999378006311 Ligand Binding Site [chemical binding]; other site 999378006312 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 999378006313 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 999378006314 homoserine kinase; Provisional; Region: PRK01212 999378006315 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 999378006316 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 999378006317 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 999378006318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999378006319 catalytic residue [active] 999378006320 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 999378006321 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 999378006322 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 999378006323 aspartate kinase; Reviewed; Region: PRK09034 999378006324 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 999378006325 nucleotide binding site [chemical binding]; other site 999378006326 substrate binding site [chemical binding]; other site 999378006327 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 999378006328 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 999378006329 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 999378006330 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 999378006331 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 999378006332 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 999378006333 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 999378006334 homodimer interface [polypeptide binding]; other site 999378006335 ligand binding site [chemical binding]; other site 999378006336 NAD binding site [chemical binding]; other site 999378006337 catalytic site [active] 999378006338 aromatic amino acid aminotransferase; Validated; Region: PRK07309 999378006339 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 999378006340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999378006341 homodimer interface [polypeptide binding]; other site 999378006342 catalytic residue [active] 999378006343 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 999378006344 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 999378006345 nucleotide binding site/active site [active] 999378006346 HIT family signature motif; other site 999378006347 catalytic residue [active] 999378006348 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 999378006349 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 999378006350 active site 999378006351 dimer interface [polypeptide binding]; other site 999378006352 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 999378006353 Ligand Binding Site [chemical binding]; other site 999378006354 Molecular Tunnel; other site 999378006355 Predicted integral membrane protein [Function unknown]; Region: COG0392 999378006356 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 999378006357 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 999378006358 active site 999378006359 metal binding site [ion binding]; metal-binding site 999378006360 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 999378006361 UbiA prenyltransferase family; Region: UbiA; pfam01040 999378006362 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 999378006363 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 999378006364 substrate binding pocket [chemical binding]; other site 999378006365 chain length determination region; other site 999378006366 substrate-Mg2+ binding site; other site 999378006367 catalytic residues [active] 999378006368 aspartate-rich region 1; other site 999378006369 active site lid residues [active] 999378006370 aspartate-rich region 2; other site 999378006371 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 999378006372 propionate/acetate kinase; Provisional; Region: PRK12379 999378006373 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 999378006374 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378006375 Walker A/P-loop; other site 999378006376 ATP binding site [chemical binding]; other site 999378006377 Q-loop/lid; other site 999378006378 ABC transporter signature motif; other site 999378006379 Walker B; other site 999378006380 D-loop; other site 999378006381 H-loop/switch region; other site 999378006382 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 999378006383 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 999378006384 Predicted transcriptional regulators [Transcription]; Region: COG1725 999378006385 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999378006386 DNA-binding site [nucleotide binding]; DNA binding site 999378006387 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 999378006388 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 999378006389 Walker A/P-loop; other site 999378006390 ATP binding site [chemical binding]; other site 999378006391 Q-loop/lid; other site 999378006392 ABC transporter signature motif; other site 999378006393 Walker B; other site 999378006394 D-loop; other site 999378006395 H-loop/switch region; other site 999378006396 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 999378006397 glucose-1-dehydrogenase; Provisional; Region: PRK08936 999378006398 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 999378006399 NAD binding site [chemical binding]; other site 999378006400 homodimer interface [polypeptide binding]; other site 999378006401 active site 999378006402 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 999378006403 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 999378006404 hexamer interface [polypeptide binding]; other site 999378006405 ligand binding site [chemical binding]; other site 999378006406 putative active site [active] 999378006407 NAD(P) binding site [chemical binding]; other site 999378006408 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 999378006409 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 999378006410 tetramer interface [polypeptide binding]; other site 999378006411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999378006412 catalytic residue [active] 999378006413 potential frameshift: common BLAST hit: gi|81427933|ref|YP_394932.1| oligopeptide transporter 999378006414 OPT oligopeptide transporter protein; Region: OPT; cl14607 999378006415 OPT oligopeptide transporter protein; Region: OPT; cl14607 999378006416 OPT oligopeptide transporter protein; Region: OPT; cl14607 999378006417 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 999378006418 Peptidase family C69; Region: Peptidase_C69; pfam03577 999378006419 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 999378006420 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 999378006421 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 999378006422 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 999378006423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378006424 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999378006425 putative substrate translocation pore; other site 999378006426 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999378006427 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999378006428 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 999378006429 beta-galactosidase; Region: BGL; TIGR03356 999378006430 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 999378006431 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 999378006432 active site turn [active] 999378006433 phosphorylation site [posttranslational modification] 999378006434 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 999378006435 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 999378006436 HPr interaction site; other site 999378006437 glycerol kinase (GK) interaction site [polypeptide binding]; other site 999378006438 active site 999378006439 phosphorylation site [posttranslational modification] 999378006440 transcriptional antiterminator BglG; Provisional; Region: PRK09772 999378006441 CAT RNA binding domain; Region: CAT_RBD; smart01061 999378006442 PRD domain; Region: PRD; pfam00874 999378006443 PRD domain; Region: PRD; pfam00874 999378006444 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 999378006445 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999378006446 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 999378006447 Walker A/P-loop; other site 999378006448 ATP binding site [chemical binding]; other site 999378006449 Q-loop/lid; other site 999378006450 ABC transporter signature motif; other site 999378006451 Walker B; other site 999378006452 D-loop; other site 999378006453 H-loop/switch region; other site 999378006454 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999378006455 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 999378006456 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378006457 Walker A/P-loop; other site 999378006458 ATP binding site [chemical binding]; other site 999378006459 Q-loop/lid; other site 999378006460 ABC transporter signature motif; other site 999378006461 Walker B; other site 999378006462 D-loop; other site 999378006463 H-loop/switch region; other site 999378006464 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 999378006465 trimer interface [polypeptide binding]; other site 999378006466 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 999378006467 Transposase; Region: HTH_Tnp_1; pfam01527 999378006468 putative transposase OrfB; Reviewed; Region: PHA02517 999378006469 HTH-like domain; Region: HTH_21; pfam13276 999378006470 Integrase core domain; Region: rve; pfam00665 999378006471 Integrase core domain; Region: rve_3; pfam13683 999378006472 CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd12218 999378006473 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 999378006474 tetramer interface [polypeptide binding]; other site 999378006475 putative DNA binding site [nucleotide binding]; other site 999378006476 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 999378006477 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 999378006478 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 999378006479 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 999378006480 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 999378006481 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 999378006482 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999378006483 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 999378006484 Walker A/P-loop; other site 999378006485 ATP binding site [chemical binding]; other site 999378006486 Q-loop/lid; other site 999378006487 ABC transporter signature motif; other site 999378006488 Walker B; other site 999378006489 D-loop; other site 999378006490 H-loop/switch region; other site 999378006491 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 999378006492 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999378006493 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378006494 Walker A/P-loop; other site 999378006495 ATP binding site [chemical binding]; other site 999378006496 Q-loop/lid; other site 999378006497 ABC transporter signature motif; other site 999378006498 Walker B; other site 999378006499 D-loop; other site 999378006500 H-loop/switch region; other site 999378006501 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 999378006502 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 999378006503 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 999378006504 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 999378006505 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 999378006506 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 999378006507 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 999378006508 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 999378006509 adenosine deaminase; Provisional; Region: PRK09358 999378006510 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 999378006511 active site 999378006512 Protein of unknown function (DUF460); Region: DUF460; pfam04312 999378006513 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 999378006514 EamA-like transporter family; Region: EamA; pfam00892 999378006515 EamA-like transporter family; Region: EamA; pfam00892 999378006516 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 999378006517 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 999378006518 Ligand Binding Site [chemical binding]; other site 999378006519 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999378006520 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999378006521 non-specific DNA binding site [nucleotide binding]; other site 999378006522 salt bridge; other site 999378006523 sequence-specific DNA binding site [nucleotide binding]; other site 999378006524 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 999378006525 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 999378006526 epoxyqueuosine reductase; Region: TIGR00276 999378006527 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 999378006528 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 999378006529 protein binding surface [polypeptide binding]; other site 999378006530 HEAT repeats; Region: HEAT_2; pfam13646 999378006531 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 999378006532 Helix-turn-helix domain; Region: HTH_38; pfam13936 999378006533 Integrase core domain; Region: rve; pfam00665 999378006534 BioY family; Region: BioY; pfam02632 999378006535 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 999378006536 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 999378006537 DNA binding residues [nucleotide binding] 999378006538 putative dimer interface [polypeptide binding]; other site 999378006539 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 999378006540 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 999378006541 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 999378006542 catalytic Zn binding site [ion binding]; other site 999378006543 NAD(P) binding site [chemical binding]; other site 999378006544 structural Zn binding site [ion binding]; other site 999378006545 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 999378006546 NADH(P)-binding; Region: NAD_binding_10; pfam13460 999378006547 putative NAD(P) binding site [chemical binding]; other site 999378006548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999378006549 S-adenosylmethionine binding site [chemical binding]; other site 999378006550 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 999378006551 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 999378006552 catalytic triad [active] 999378006553 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 999378006554 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 999378006555 Domain of unknown function DUF21; Region: DUF21; pfam01595 999378006556 FOG: CBS domain [General function prediction only]; Region: COG0517 999378006557 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 999378006558 Transporter associated domain; Region: CorC_HlyC; smart01091 999378006559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378006560 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999378006561 Maf-like protein; Region: Maf; pfam02545 999378006562 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 999378006563 active site 999378006564 dimer interface [polypeptide binding]; other site 999378006565 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 999378006566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999378006567 ATP binding site [chemical binding]; other site 999378006568 Mg2+ binding site [ion binding]; other site 999378006569 G-X-G motif; other site 999378006570 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 999378006571 ATP binding site [chemical binding]; other site 999378006572 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 999378006573 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 999378006574 MutS domain I; Region: MutS_I; pfam01624 999378006575 MutS domain II; Region: MutS_II; pfam05188 999378006576 MutS domain III; Region: MutS_III; pfam05192 999378006577 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 999378006578 Walker A/P-loop; other site 999378006579 ATP binding site [chemical binding]; other site 999378006580 Q-loop/lid; other site 999378006581 ABC transporter signature motif; other site 999378006582 Walker B; other site 999378006583 D-loop; other site 999378006584 H-loop/switch region; other site 999378006585 Amino acid permease; Region: AA_permease_2; pfam13520 999378006586 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 999378006587 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 999378006588 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 999378006589 ring oligomerisation interface [polypeptide binding]; other site 999378006590 ATP/Mg binding site [chemical binding]; other site 999378006591 stacking interactions; other site 999378006592 hinge regions; other site 999378006593 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 999378006594 oligomerisation interface [polypeptide binding]; other site 999378006595 mobile loop; other site 999378006596 roof hairpin; other site 999378006597 CAAX protease self-immunity; Region: Abi; pfam02517 999378006598 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 999378006599 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 999378006600 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 999378006601 Walker A/P-loop; other site 999378006602 ATP binding site [chemical binding]; other site 999378006603 Q-loop/lid; other site 999378006604 ABC transporter signature motif; other site 999378006605 Walker B; other site 999378006606 D-loop; other site 999378006607 H-loop/switch region; other site 999378006608 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999378006609 DNA-binding site [nucleotide binding]; DNA binding site 999378006610 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 999378006611 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 999378006612 CoA binding domain; Region: CoA_binding; pfam02629 999378006613 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 999378006614 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378006615 Walker A/P-loop; other site 999378006616 ATP binding site [chemical binding]; other site 999378006617 Q-loop/lid; other site 999378006618 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 999378006619 ABC transporter signature motif; other site 999378006620 Walker B; other site 999378006621 D-loop; other site 999378006622 ABC transporter; Region: ABC_tran_2; pfam12848 999378006623 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 999378006624 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 999378006625 active site 999378006626 P-loop; other site 999378006627 phosphorylation site [posttranslational modification] 999378006628 UGMP family protein; Validated; Region: PRK09604 999378006629 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 999378006630 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 999378006631 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 999378006632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999378006633 Coenzyme A binding pocket [chemical binding]; other site 999378006634 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 999378006635 Glycoprotease family; Region: Peptidase_M22; pfam00814 999378006636 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 999378006637 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 999378006638 active site 999378006639 homotetramer interface [polypeptide binding]; other site 999378006640 homodimer interface [polypeptide binding]; other site 999378006641 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 999378006642 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 999378006643 active site 999378006644 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 999378006645 active site 2 [active] 999378006646 active site 1 [active] 999378006647 Predicted methyltransferases [General function prediction only]; Region: COG0313 999378006648 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 999378006649 putative SAM binding site [chemical binding]; other site 999378006650 putative homodimer interface [polypeptide binding]; other site 999378006651 Protein of unknown function (DUF972); Region: DUF972; pfam06156 999378006652 DNA polymerase III subunit delta'; Validated; Region: PRK08058 999378006653 DNA polymerase III subunit delta'; Validated; Region: PRK08485 999378006654 Protein of unknown function (DUF970); Region: DUF970; pfam06153 999378006655 thymidylate kinase; Validated; Region: tmk; PRK00698 999378006656 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 999378006657 TMP-binding site; other site 999378006658 ATP-binding site [chemical binding]; other site 999378006659 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 999378006660 recombination protein RecR; Reviewed; Region: recR; PRK00076 999378006661 RecR protein; Region: RecR; pfam02132 999378006662 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 999378006663 putative active site [active] 999378006664 putative metal-binding site [ion binding]; other site 999378006665 tetramer interface [polypeptide binding]; other site 999378006666 hypothetical protein; Validated; Region: PRK00153 999378006667 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 999378006668 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999378006669 Walker A motif; other site 999378006670 ATP binding site [chemical binding]; other site 999378006671 Walker B motif; other site 999378006672 arginine finger; other site 999378006673 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 999378006674 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 999378006675 nucleoside/Zn binding site; other site 999378006676 dimer interface [polypeptide binding]; other site 999378006677 catalytic motif [active] 999378006678 Methyltransferase domain; Region: Methyltransf_31; pfam13847 999378006679 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999378006680 S-adenosylmethionine binding site [chemical binding]; other site 999378006681 Predicted integral membrane protein [Function unknown]; Region: COG0392 999378006682 Uncharacterized conserved protein [Function unknown]; Region: COG2898 999378006683 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 999378006684 Transcriptional regulators [Transcription]; Region: PurR; COG1609 999378006685 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 999378006686 DNA binding site [nucleotide binding] 999378006687 domain linker motif; other site 999378006688 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 999378006689 putative dimerization interface [polypeptide binding]; other site 999378006690 putative ligand binding site [chemical binding]; other site 999378006691 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 999378006692 putative active site [active] 999378006693 catalytic triad [active] 999378006694 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 999378006695 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 999378006696 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 999378006697 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 999378006698 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 999378006699 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 999378006700 core dimer interface [polypeptide binding]; other site 999378006701 peripheral dimer interface [polypeptide binding]; other site 999378006702 L10 interface [polypeptide binding]; other site 999378006703 L11 interface [polypeptide binding]; other site 999378006704 putative EF-Tu interaction site [polypeptide binding]; other site 999378006705 putative EF-G interaction site [polypeptide binding]; other site 999378006706 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 999378006707 23S rRNA interface [nucleotide binding]; other site 999378006708 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 999378006709 drug efflux system protein MdtG; Provisional; Region: PRK09874 999378006710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378006711 putative substrate translocation pore; other site 999378006712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378006713 putative substrate translocation pore; other site 999378006714 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 999378006715 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 999378006716 NAD(P) binding site [chemical binding]; other site 999378006717 catalytic residues [active] 999378006718 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 999378006719 mRNA/rRNA interface [nucleotide binding]; other site 999378006720 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 999378006721 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 999378006722 23S rRNA interface [nucleotide binding]; other site 999378006723 L7/L12 interface [polypeptide binding]; other site 999378006724 putative thiostrepton binding site; other site 999378006725 L25 interface [polypeptide binding]; other site 999378006726 magnesium-transporting ATPase; Provisional; Region: PRK15122 999378006727 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 999378006728 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 999378006729 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 999378006730 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378006731 motif II; other site 999378006732 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 999378006733 amidase; Provisional; Region: PRK06529 999378006734 Amidase; Region: Amidase; cl11426 999378006735 Domain of unknown function (DU1801); Region: DUF1801; cl17490 999378006736 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 999378006737 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 999378006738 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 999378006739 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 999378006740 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 999378006741 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 999378006742 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 999378006743 putative homodimer interface [polypeptide binding]; other site 999378006744 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 999378006745 heterodimer interface [polypeptide binding]; other site 999378006746 homodimer interface [polypeptide binding]; other site 999378006747 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 999378006748 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 999378006749 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 999378006750 UbiA prenyltransferase family; Region: UbiA; pfam01040 999378006751 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 999378006752 UbiA prenyltransferase family; Region: UbiA; pfam01040 999378006753 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 999378006754 ApbE family; Region: ApbE; pfam02424 999378006755 FMN-binding domain; Region: FMN_bind; cl01081 999378006756 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 999378006757 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 999378006758 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 999378006759 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 999378006760 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 999378006761 trimer interface [polypeptide binding]; other site 999378006762 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 999378006763 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 999378006764 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 999378006765 substrate binding pocket [chemical binding]; other site 999378006766 chain length determination region; other site 999378006767 substrate-Mg2+ binding site; other site 999378006768 catalytic residues [active] 999378006769 aspartate-rich region 1; other site 999378006770 active site lid residues [active] 999378006771 aspartate-rich region 2; other site 999378006772 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 999378006773 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 999378006774 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 999378006775 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 999378006776 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 999378006777 YacP-like NYN domain; Region: NYN_YacP; pfam05991 999378006778 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 999378006779 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 999378006780 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 999378006781 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 999378006782 active site 999378006783 metal binding site [ion binding]; metal-binding site 999378006784 dimerization interface [polypeptide binding]; other site 999378006785 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 999378006786 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 999378006787 active site 999378006788 HIGH motif; other site 999378006789 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 999378006790 KMSKS motif; other site 999378006791 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 999378006792 tRNA binding surface [nucleotide binding]; other site 999378006793 anticodon binding site; other site 999378006794 FAD binding domain; Region: FAD_binding_4; pfam01565 999378006795 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 999378006796 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 999378006797 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 999378006798 active site 999378006799 HIGH motif; other site 999378006800 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 999378006801 active site 999378006802 KMSKS motif; other site 999378006803 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 999378006804 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 999378006805 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 999378006806 tetramer (dimer of dimers) interface [polypeptide binding]; other site 999378006807 active site 999378006808 dimer interface [polypeptide binding]; other site 999378006809 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 999378006810 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 999378006811 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 999378006812 putative active site [active] 999378006813 potential frameshift: common BLAST hit: gi|258540515|ref|YP_003175014.1| membrane protein 999378006814 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 999378006815 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 999378006816 Predicted membrane protein [General function prediction only]; Region: COG4194 999378006817 Predicted transcriptional regulators [Transcription]; Region: COG1725 999378006818 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999378006819 DNA-binding site [nucleotide binding]; DNA binding site 999378006820 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999378006821 putative DNA binding site [nucleotide binding]; other site 999378006822 dimerization interface [polypeptide binding]; other site 999378006823 putative Zn2+ binding site [ion binding]; other site 999378006824 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 999378006825 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378006826 Walker A/P-loop; other site 999378006827 ATP binding site [chemical binding]; other site 999378006828 Q-loop/lid; other site 999378006829 ABC transporter signature motif; other site 999378006830 Walker B; other site 999378006831 D-loop; other site 999378006832 H-loop/switch region; other site 999378006833 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 999378006834 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 999378006835 ABC-2 type transporter; Region: ABC2_membrane; cl17235 999378006836 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 999378006837 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 999378006838 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 999378006839 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 999378006840 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 999378006841 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 999378006842 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 999378006843 Walker A/P-loop; other site 999378006844 ATP binding site [chemical binding]; other site 999378006845 Q-loop/lid; other site 999378006846 ABC transporter signature motif; other site 999378006847 Walker B; other site 999378006848 D-loop; other site 999378006849 H-loop/switch region; other site 999378006850 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999378006851 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999378006852 non-specific DNA binding site [nucleotide binding]; other site 999378006853 salt bridge; other site 999378006854 sequence-specific DNA binding site [nucleotide binding]; other site 999378006855 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 999378006856 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 999378006857 putative active site [active] 999378006858 DNA repair protein RadA; Provisional; Region: PRK11823 999378006859 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 999378006860 Walker A motif/ATP binding site; other site 999378006861 ATP binding site [chemical binding]; other site 999378006862 Walker B motif; other site 999378006863 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 999378006864 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 999378006865 trimer interface [polypeptide binding]; other site 999378006866 active site 999378006867 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999378006868 Coenzyme A binding pocket [chemical binding]; other site 999378006869 Protein of unknown function (DUF805); Region: DUF805; pfam05656 999378006870 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 999378006871 trimer interface [polypeptide binding]; other site 999378006872 active site 999378006873 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 999378006874 trimer interface [polypeptide binding]; other site 999378006875 active site 999378006876 G bulge; other site 999378006877 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 999378006878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378006879 Walker A/P-loop; other site 999378006880 ATP binding site [chemical binding]; other site 999378006881 Q-loop/lid; other site 999378006882 ABC transporter signature motif; other site 999378006883 Walker B; other site 999378006884 D-loop; other site 999378006885 H-loop/switch region; other site 999378006886 K+ potassium transporter; Region: K_trans; pfam02705 999378006887 pyruvate phosphate dikinase; Provisional; Region: PRK09279 999378006888 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 999378006889 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 999378006890 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 999378006891 HTH domain; Region: HTH_11; pfam08279 999378006892 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 999378006893 FOG: CBS domain [General function prediction only]; Region: COG0517 999378006894 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 999378006895 catalytic core [active] 999378006896 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 999378006897 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 999378006898 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 999378006899 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 999378006900 teramer interface [polypeptide binding]; other site 999378006901 active site 999378006902 FMN binding site [chemical binding]; other site 999378006903 catalytic residues [active] 999378006904 CsbD-like; Region: CsbD; pfam05532 999378006905 phosphopentomutase; Provisional; Region: PRK05362 999378006906 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 999378006907 benzoate transport; Region: 2A0115; TIGR00895 999378006908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378006909 putative substrate translocation pore; other site 999378006910 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 999378006911 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 999378006912 benzoate transport; Region: 2A0115; TIGR00895 999378006913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378006914 putative substrate translocation pore; other site 999378006915 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 999378006916 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 999378006917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378006918 H+ Antiporter protein; Region: 2A0121; TIGR00900 999378006919 putative substrate translocation pore; other site 999378006920 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 999378006921 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 999378006922 putative catalytic cysteine [active] 999378006923 gamma-glutamyl kinase; Provisional; Region: PRK05429 999378006924 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 999378006925 nucleotide binding site [chemical binding]; other site 999378006926 homotetrameric interface [polypeptide binding]; other site 999378006927 putative phosphate binding site [ion binding]; other site 999378006928 putative allosteric binding site; other site 999378006929 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 999378006930 active site 999378006931 catalytic site [active] 999378006932 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 999378006933 Cna protein B-type domain; Region: Cna_B; pfam05738 999378006934 Cna protein B-type domain; Region: Cna_B; pfam05738 999378006935 Cna protein B-type domain; Region: Cna_B; pfam05738 999378006936 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 999378006937 Uncharacterized conserved protein [Function unknown]; Region: COG3410 999378006938 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 999378006939 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999378006940 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999378006941 non-specific DNA binding site [nucleotide binding]; other site 999378006942 salt bridge; other site 999378006943 sequence-specific DNA binding site [nucleotide binding]; other site 999378006944 Predicted transcriptional regulators [Transcription]; Region: COG1695 999378006945 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 999378006946 Enterocin A Immunity; Region: EntA_Immun; pfam08951 999378006947 Enterocin A Immunity; Region: EntA_Immun; pfam08951 999378006948 Enterocin A Immunity; Region: EntA_Immun; pfam08951 999378006949 Uncharacterized conserved protein [Function unknown]; Region: COG2966 999378006950 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 999378006951 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 999378006952 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 999378006953 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 999378006954 HlyD family secretion protein; Region: HlyD_3; pfam13437 999378006955 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 999378006956 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 999378006957 putative active site [active] 999378006958 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999378006959 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378006960 Walker A/P-loop; other site 999378006961 ATP binding site [chemical binding]; other site 999378006962 Q-loop/lid; other site 999378006963 ABC transporter signature motif; other site 999378006964 Walker B; other site 999378006965 D-loop; other site 999378006966 H-loop/switch region; other site 999378006967 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 999378006968 putative active site [active] 999378006969 sensory histidine kinase DcuS; Provisional; Region: PRK11086 999378006970 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 999378006971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999378006972 active site 999378006973 phosphorylation site [posttranslational modification] 999378006974 intermolecular recognition site; other site 999378006975 dimerization interface [polypeptide binding]; other site 999378006976 LytTr DNA-binding domain; Region: LytTR; pfam04397 999378006977 CAAX protease self-immunity; Region: Abi; pfam02517 999378006978 CAAX protease self-immunity; Region: Abi; pfam02517 999378006979 Enterocin A Immunity; Region: EntA_Immun; pfam08951 999378006980 maltose O-acetyltransferase; Provisional; Region: PRK10092 999378006981 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 999378006982 active site 999378006983 substrate binding site [chemical binding]; other site 999378006984 trimer interface [polypeptide binding]; other site 999378006985 CoA binding site [chemical binding]; other site 999378006986 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 999378006987 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 999378006988 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 999378006989 active site 999378006990 catalytic tetrad [active] 999378006991 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 999378006992 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 999378006993 NAD(P) binding site [chemical binding]; other site 999378006994 active site 999378006995 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 999378006996 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 999378006997 putative active site [active] 999378006998 putative FMN binding site [chemical binding]; other site 999378006999 putative substrate binding site [chemical binding]; other site 999378007000 putative catalytic residue [active] 999378007001 fumarate hydratase; Reviewed; Region: fumC; PRK00485 999378007002 Class II fumarases; Region: Fumarase_classII; cd01362 999378007003 active site 999378007004 tetramer interface [polypeptide binding]; other site 999378007005 manganese transport protein MntH; Reviewed; Region: PRK00701 999378007006 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 999378007007 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 999378007008 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 999378007009 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 999378007010 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 999378007011 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378007012 motif II; other site 999378007013 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 999378007014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378007015 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 999378007016 putative substrate translocation pore; other site 999378007017 multicopper oxidase; Provisional; Region: PRK10965 999378007018 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 999378007019 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 999378007020 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 999378007021 Cation efflux family; Region: Cation_efflux; cl00316 999378007022 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999378007023 dimerization interface [polypeptide binding]; other site 999378007024 putative DNA binding site [nucleotide binding]; other site 999378007025 putative Zn2+ binding site [ion binding]; other site 999378007026 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 999378007027 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 999378007028 metal binding site [ion binding]; metal-binding site 999378007029 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 999378007030 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 999378007031 ABC-ATPase subunit interface; other site 999378007032 dimer interface [polypeptide binding]; other site 999378007033 putative PBP binding regions; other site 999378007034 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 999378007035 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 999378007036 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 999378007037 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 999378007038 NAD binding site [chemical binding]; other site 999378007039 catalytic residues [active] 999378007040 substrate binding site [chemical binding]; other site 999378007041 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 999378007042 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 999378007043 Helix-turn-helix domain; Region: HTH_38; pfam13936 999378007044 Integrase core domain; Region: rve; pfam00665 999378007045 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 999378007046 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 999378007047 metal binding site [ion binding]; metal-binding site 999378007048 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 999378007049 NADH(P)-binding; Region: NAD_binding_10; pfam13460 999378007050 putative NAD(P) binding site [chemical binding]; other site 999378007051 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 999378007052 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 999378007053 nudix motif; other site 999378007054 Collagen binding domain; Region: Collagen_bind; pfam05737 999378007055 Cna protein B-type domain; Region: Cna_B; pfam05738 999378007056 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 999378007057 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 999378007058 metal binding site [ion binding]; metal-binding site 999378007059 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 999378007060 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 999378007061 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 999378007062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999378007063 Walker A motif; other site 999378007064 ATP binding site [chemical binding]; other site 999378007065 Walker B motif; other site 999378007066 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 999378007067 Enolase, N-terminal domain; Region: Enolase_N; pfam03952 999378007068 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 999378007069 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 999378007070 membrane-bound complex binding site; other site 999378007071 hinge residues; other site 999378007072 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 999378007073 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 999378007074 Walker A/P-loop; other site 999378007075 ATP binding site [chemical binding]; other site 999378007076 Q-loop/lid; other site 999378007077 ABC transporter signature motif; other site 999378007078 Walker B; other site 999378007079 D-loop; other site 999378007080 H-loop/switch region; other site 999378007081 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 999378007082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378007083 dimer interface [polypeptide binding]; other site 999378007084 conserved gate region; other site 999378007085 putative PBP binding loops; other site 999378007086 ABC-ATPase subunit interface; other site 999378007087 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 999378007088 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378007089 dimer interface [polypeptide binding]; other site 999378007090 conserved gate region; other site 999378007091 putative PBP binding loops; other site 999378007092 ABC-ATPase subunit interface; other site 999378007093 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 999378007094 Helix-turn-helix domain; Region: HTH_38; pfam13936 999378007095 Integrase core domain; Region: rve; pfam00665 999378007096 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 999378007097 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 999378007098 substrate binding pocket [chemical binding]; other site 999378007099 membrane-bound complex binding site; other site 999378007100 hinge residues; other site 999378007101 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 999378007102 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 999378007103 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 999378007104 acyl-activating enzyme (AAE) consensus motif; other site 999378007105 acyl-activating enzyme (AAE) consensus motif; other site 999378007106 putative AMP binding site [chemical binding]; other site 999378007107 putative active site [active] 999378007108 putative CoA binding site [chemical binding]; other site 999378007109 Acyltransferase family; Region: Acyl_transf_3; pfam01757 999378007110 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 999378007111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378007112 Walker A/P-loop; other site 999378007113 ATP binding site [chemical binding]; other site 999378007114 Q-loop/lid; other site 999378007115 ABC transporter signature motif; other site 999378007116 Walker B; other site 999378007117 D-loop; other site 999378007118 H-loop/switch region; other site 999378007119 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 999378007120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378007121 putative PBP binding loops; other site 999378007122 dimer interface [polypeptide binding]; other site 999378007123 ABC-ATPase subunit interface; other site 999378007124 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 999378007125 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 999378007126 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 999378007127 ABC transporter; Region: ABC_tran; pfam00005 999378007128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378007129 Q-loop/lid; other site 999378007130 ABC transporter signature motif; other site 999378007131 Walker B; other site 999378007132 D-loop; other site 999378007133 H-loop/switch region; other site 999378007134 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 999378007135 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 999378007136 23S rRNA interface [nucleotide binding]; other site 999378007137 L3 interface [polypeptide binding]; other site 999378007138 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999378007139 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999378007140 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 999378007141 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 999378007142 Walker A/P-loop; other site 999378007143 ATP binding site [chemical binding]; other site 999378007144 Q-loop/lid; other site 999378007145 ABC transporter signature motif; other site 999378007146 Walker B; other site 999378007147 D-loop; other site 999378007148 H-loop/switch region; other site 999378007149 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 999378007150 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 999378007151 DNA binding residues [nucleotide binding] 999378007152 dimer interface [polypeptide binding]; other site 999378007153 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 999378007154 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 999378007155 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 999378007156 dimerization interface 3.5A [polypeptide binding]; other site 999378007157 active site 999378007158 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 999378007159 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 999378007160 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 999378007161 Walker A/P-loop; other site 999378007162 ATP binding site [chemical binding]; other site 999378007163 Q-loop/lid; other site 999378007164 ABC transporter signature motif; other site 999378007165 Walker B; other site 999378007166 D-loop; other site 999378007167 H-loop/switch region; other site 999378007168 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 999378007169 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 999378007170 Walker A/P-loop; other site 999378007171 ATP binding site [chemical binding]; other site 999378007172 Q-loop/lid; other site 999378007173 ABC transporter signature motif; other site 999378007174 Walker B; other site 999378007175 D-loop; other site 999378007176 H-loop/switch region; other site 999378007177 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 999378007178 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 999378007179 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 999378007180 alphaNTD homodimer interface [polypeptide binding]; other site 999378007181 alphaNTD - beta interaction site [polypeptide binding]; other site 999378007182 alphaNTD - beta' interaction site [polypeptide binding]; other site 999378007183 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 999378007184 30S ribosomal protein S11; Validated; Region: PRK05309 999378007185 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 999378007186 30S ribosomal protein S13; Region: bact_S13; TIGR03631 999378007187 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 999378007188 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 999378007189 rRNA binding site [nucleotide binding]; other site 999378007190 predicted 30S ribosome binding site; other site 999378007191 adenylate kinase; Reviewed; Region: adk; PRK00279 999378007192 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 999378007193 AMP-binding site [chemical binding]; other site 999378007194 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 999378007195 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 999378007196 SecY translocase; Region: SecY; pfam00344 999378007197 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 999378007198 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 999378007199 23S rRNA binding site [nucleotide binding]; other site 999378007200 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 999378007201 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 999378007202 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 999378007203 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 999378007204 5S rRNA interface [nucleotide binding]; other site 999378007205 L27 interface [polypeptide binding]; other site 999378007206 23S rRNA interface [nucleotide binding]; other site 999378007207 L5 interface [polypeptide binding]; other site 999378007208 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 999378007209 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 999378007210 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 999378007211 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 999378007212 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 999378007213 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 999378007214 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 999378007215 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 999378007216 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 999378007217 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 999378007218 RNA binding site [nucleotide binding]; other site 999378007219 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 999378007220 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 999378007221 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 999378007222 23S rRNA interface [nucleotide binding]; other site 999378007223 putative translocon interaction site; other site 999378007224 signal recognition particle (SRP54) interaction site; other site 999378007225 L23 interface [polypeptide binding]; other site 999378007226 trigger factor interaction site; other site 999378007227 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 999378007228 23S rRNA interface [nucleotide binding]; other site 999378007229 5S rRNA interface [nucleotide binding]; other site 999378007230 putative antibiotic binding site [chemical binding]; other site 999378007231 L25 interface [polypeptide binding]; other site 999378007232 L27 interface [polypeptide binding]; other site 999378007233 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 999378007234 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 999378007235 G-X-X-G motif; other site 999378007236 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 999378007237 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 999378007238 putative translocon binding site; other site 999378007239 protein-rRNA interface [nucleotide binding]; other site 999378007240 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 999378007241 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 999378007242 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 999378007243 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 999378007244 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 999378007245 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 999378007246 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 999378007247 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 999378007248 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 999378007249 peroxiredoxin; Region: AhpC; TIGR03137 999378007250 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 999378007251 dimer interface [polypeptide binding]; other site 999378007252 decamer (pentamer of dimers) interface [polypeptide binding]; other site 999378007253 catalytic triad [active] 999378007254 peroxidatic and resolving cysteines [active] 999378007255 Predicted transcriptional regulator [Transcription]; Region: COG2378 999378007256 WYL domain; Region: WYL; pfam13280 999378007257 elongation factor G; Reviewed; Region: PRK12739 999378007258 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 999378007259 G1 box; other site 999378007260 putative GEF interaction site [polypeptide binding]; other site 999378007261 GTP/Mg2+ binding site [chemical binding]; other site 999378007262 Switch I region; other site 999378007263 G2 box; other site 999378007264 G3 box; other site 999378007265 Switch II region; other site 999378007266 G4 box; other site 999378007267 G5 box; other site 999378007268 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 999378007269 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 999378007270 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 999378007271 30S ribosomal protein S7; Validated; Region: PRK05302 999378007272 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 999378007273 S17 interaction site [polypeptide binding]; other site 999378007274 S8 interaction site; other site 999378007275 16S rRNA interaction site [nucleotide binding]; other site 999378007276 streptomycin interaction site [chemical binding]; other site 999378007277 23S rRNA interaction site [nucleotide binding]; other site 999378007278 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 999378007279 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 999378007280 Cna protein B-type domain; Region: Cna_B; pfam05738 999378007281 Cna protein B-type domain; Region: Cna_B; pfam05738 999378007282 Cna protein B-type domain; Region: Cna_B; pfam05738 999378007283 Cna protein B-type domain; Region: Cna_B; pfam05738 999378007284 Cna protein B-type domain; Region: Cna_B; pfam05738 999378007285 Cna protein B-type domain; Region: Cna_B; pfam05738 999378007286 Cna protein B-type domain; Region: Cna_B; pfam05738 999378007287 Cna protein B-type domain; Region: Cna_B; pfam05738 999378007288 Cna protein B-type domain; Region: Cna_B; pfam05738 999378007289 Cna protein B-type domain; Region: Cna_B; pfam05738 999378007290 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 999378007291 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 999378007292 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 999378007293 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 999378007294 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 999378007295 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 999378007296 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 999378007297 DNA binding site [nucleotide binding] 999378007298 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 999378007299 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 999378007300 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 999378007301 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 999378007302 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 999378007303 RPB1 interaction site [polypeptide binding]; other site 999378007304 RPB10 interaction site [polypeptide binding]; other site 999378007305 RPB11 interaction site [polypeptide binding]; other site 999378007306 RPB3 interaction site [polypeptide binding]; other site 999378007307 RPB12 interaction site [polypeptide binding]; other site 999378007308 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 999378007309 Clp amino terminal domain; Region: Clp_N; pfam02861 999378007310 Clp amino terminal domain; Region: Clp_N; pfam02861 999378007311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999378007312 Walker A motif; other site 999378007313 ATP binding site [chemical binding]; other site 999378007314 Walker B motif; other site 999378007315 arginine finger; other site 999378007316 UvrB/uvrC motif; Region: UVR; pfam02151 999378007317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999378007318 Walker A motif; other site 999378007319 ATP binding site [chemical binding]; other site 999378007320 Walker B motif; other site 999378007321 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 999378007322 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 999378007323 Domain of unknown function (DUF4323); Region: DUF4323; pfam14211 999378007324 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 999378007325 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 999378007326 dimer interface [polypeptide binding]; other site 999378007327 putative anticodon binding site; other site 999378007328 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 999378007329 motif 1; other site 999378007330 active site 999378007331 motif 2; other site 999378007332 motif 3; other site 999378007333 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 999378007334 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 999378007335 FMN binding site [chemical binding]; other site 999378007336 active site 999378007337 catalytic residues [active] 999378007338 substrate binding site [chemical binding]; other site 999378007339 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 999378007340 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 999378007341 dimerization interface [polypeptide binding]; other site 999378007342 domain crossover interface; other site 999378007343 redox-dependent activation switch; other site 999378007344 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 999378007345 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 999378007346 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 999378007347 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 999378007348 legume lectins; Region: lectin_L-type; cl14058 999378007349 homotetramer interaction site [polypeptide binding]; other site 999378007350 homodimer interaction site [polypeptide binding]; other site 999378007351 carbohydrate binding site [chemical binding]; other site 999378007352 metal binding site [ion binding]; metal-binding site 999378007353 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 999378007354 WxL domain surface cell wall-binding; Region: WxL; pfam13731 999378007355 FtsH Extracellular; Region: FtsH_ext; pfam06480 999378007356 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 999378007357 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999378007358 Walker A motif; other site 999378007359 ATP binding site [chemical binding]; other site 999378007360 Walker B motif; other site 999378007361 arginine finger; other site 999378007362 Peptidase family M41; Region: Peptidase_M41; pfam01434 999378007363 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 999378007364 active site 999378007365 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 999378007366 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 999378007367 Ligand Binding Site [chemical binding]; other site 999378007368 TilS substrate C-terminal domain; Region: TilS_C; smart00977 999378007369 hypothetical protein; Provisional; Region: PRK08582 999378007370 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 999378007371 RNA binding site [nucleotide binding]; other site 999378007372 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 999378007373 Septum formation initiator; Region: DivIC; pfam04977 999378007374 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 999378007375 RNA binding surface [nucleotide binding]; other site 999378007376 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 999378007377 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 999378007378 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 999378007379 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 999378007380 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 999378007381 ATP binding site [chemical binding]; other site 999378007382 putative Mg++ binding site [ion binding]; other site 999378007383 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 999378007384 nucleotide binding region [chemical binding]; other site 999378007385 ATP-binding site [chemical binding]; other site 999378007386 TRCF domain; Region: TRCF; pfam03461 999378007387 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 999378007388 putative active site [active] 999378007389 catalytic residue [active] 999378007390 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 999378007391 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 999378007392 tetramer (dimer of dimers) interface [polypeptide binding]; other site 999378007393 NAD binding site [chemical binding]; other site 999378007394 dimer interface [polypeptide binding]; other site 999378007395 substrate binding site [chemical binding]; other site 999378007396 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 999378007397 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 999378007398 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 999378007399 Predicted transcriptional regulators [Transcription]; Region: COG1695 999378007400 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 999378007401 Predicted membrane protein [Function unknown]; Region: COG1511 999378007402 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 999378007403 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 999378007404 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 999378007405 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 999378007406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 999378007407 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 999378007408 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 999378007409 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 999378007410 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 999378007411 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 999378007412 active site 999378007413 dimer interface [polypeptide binding]; other site 999378007414 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 999378007415 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 999378007416 active site 999378007417 FMN binding site [chemical binding]; other site 999378007418 substrate binding site [chemical binding]; other site 999378007419 3Fe-4S cluster binding site [ion binding]; other site 999378007420 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 999378007421 domain interface; other site 999378007422 QueT transporter; Region: QueT; pfam06177 999378007423 PemK-like protein; Region: PemK; pfam02452 999378007424 hypothetical protein; Region: PHA01623 999378007425 alanine racemase; Reviewed; Region: alr; PRK00053 999378007426 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 999378007427 active site 999378007428 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 999378007429 dimer interface [polypeptide binding]; other site 999378007430 substrate binding site [chemical binding]; other site 999378007431 catalytic residues [active] 999378007432 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 999378007433 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 999378007434 DEAD-like helicases superfamily; Region: DEXDc; smart00487 999378007435 ATP binding site [chemical binding]; other site 999378007436 Mg++ binding site [ion binding]; other site 999378007437 motif III; other site 999378007438 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 999378007439 nucleotide binding region [chemical binding]; other site 999378007440 ATP-binding site [chemical binding]; other site 999378007441 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 999378007442 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 999378007443 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 999378007444 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 999378007445 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 999378007446 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 999378007447 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 999378007448 hinge; other site 999378007449 active site 999378007450 CTP synthetase; Validated; Region: pyrG; PRK05380 999378007451 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 999378007452 Catalytic site [active] 999378007453 active site 999378007454 UTP binding site [chemical binding]; other site 999378007455 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 999378007456 active site 999378007457 putative oxyanion hole; other site 999378007458 catalytic triad [active] 999378007459 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 999378007460 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 999378007461 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 999378007462 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 999378007463 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 999378007464 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 999378007465 Zn2+ binding site [ion binding]; other site 999378007466 Mg2+ binding site [ion binding]; other site 999378007467 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 999378007468 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 999378007469 putative active site [active] 999378007470 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 999378007471 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 999378007472 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 999378007473 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 999378007474 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 999378007475 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 999378007476 active site 999378007477 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 999378007478 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 999378007479 Substrate binding site; other site 999378007480 Mg++ binding site; other site 999378007481 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 999378007482 active site 999378007483 substrate binding site [chemical binding]; other site 999378007484 CoA binding site [chemical binding]; other site 999378007485 VanZ like family; Region: VanZ; pfam04892 999378007486 RDD family; Region: RDD; pfam06271 999378007487 pur operon repressor; Provisional; Region: PRK09213 999378007488 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 999378007489 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 999378007490 active site 999378007491 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 999378007492 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 999378007493 Walker A/P-loop; other site 999378007494 ATP binding site [chemical binding]; other site 999378007495 Q-loop/lid; other site 999378007496 ABC transporter signature motif; other site 999378007497 Walker B; other site 999378007498 D-loop; other site 999378007499 H-loop/switch region; other site 999378007500 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 999378007501 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 999378007502 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 999378007503 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 999378007504 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 999378007505 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 999378007506 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 999378007507 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 999378007508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999378007509 S-adenosylmethionine binding site [chemical binding]; other site 999378007510 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 999378007511 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 999378007512 putative active site [active] 999378007513 putative metal binding site [ion binding]; other site 999378007514 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 999378007515 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 999378007516 active site 999378007517 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 999378007518 active site 999378007519 phosphorylation site [posttranslational modification] 999378007520 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 999378007521 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 999378007522 active site 999378007523 catalytic residues [active] 999378007524 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 999378007525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999378007526 active site 999378007527 phosphorylation site [posttranslational modification] 999378007528 intermolecular recognition site; other site 999378007529 dimerization interface [polypeptide binding]; other site 999378007530 LytTr DNA-binding domain; Region: LytTR; smart00850 999378007531 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 999378007532 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 999378007533 ATP binding site [chemical binding]; other site 999378007534 Mg2+ binding site [ion binding]; other site 999378007535 G-X-G motif; other site 999378007536 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 999378007537 Transmembrane protein 231; Region: TM231; pfam10149 999378007538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378007539 Walker A/P-loop; other site 999378007540 ATP binding site [chemical binding]; other site 999378007541 Q-loop/lid; other site 999378007542 ABC transporter signature motif; other site 999378007543 Walker B; other site 999378007544 D-loop; other site 999378007545 H-loop/switch region; other site 999378007546 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 999378007547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378007548 Walker A/P-loop; other site 999378007549 ATP binding site [chemical binding]; other site 999378007550 Q-loop/lid; other site 999378007551 ABC transporter signature motif; other site 999378007552 Walker B; other site 999378007553 D-loop; other site 999378007554 H-loop/switch region; other site 999378007555 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 999378007556 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 999378007557 active site 999378007558 HIGH motif; other site 999378007559 KMSKS motif; other site 999378007560 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 999378007561 tRNA binding surface [nucleotide binding]; other site 999378007562 anticodon binding site; other site 999378007563 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 999378007564 dimer interface [polypeptide binding]; other site 999378007565 putative tRNA-binding site [nucleotide binding]; other site 999378007566 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 999378007567 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 999378007568 Protein of unknown function DUF72; Region: DUF72; pfam01904 999378007569 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 999378007570 putative active site [active] 999378007571 nucleotide binding site [chemical binding]; other site 999378007572 nudix motif; other site 999378007573 putative metal binding site [ion binding]; other site 999378007574 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 999378007575 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 999378007576 LDH/MDH dimer interface [polypeptide binding]; other site 999378007577 NAD(P) binding site [chemical binding]; other site 999378007578 substrate binding site [chemical binding]; other site 999378007579 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 999378007580 NAD-dependent deacetylase; Provisional; Region: PRK00481 999378007581 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 999378007582 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 999378007583 substrate binding site [chemical binding]; other site 999378007584 Predicted secreted protein [Function unknown]; Region: COG4086 999378007585 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 999378007586 exopolyphosphatase; Region: exo_poly_only; TIGR03706 999378007587 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 999378007588 polyphosphate kinase; Provisional; Region: PRK05443 999378007589 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 999378007590 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 999378007591 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 999378007592 putative domain interface [polypeptide binding]; other site 999378007593 putative active site [active] 999378007594 catalytic site [active] 999378007595 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 999378007596 putative domain interface [polypeptide binding]; other site 999378007597 putative active site [active] 999378007598 catalytic site [active] 999378007599 exopolyphosphatase; Region: exo_poly_only; TIGR03706 999378007600 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 999378007601 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 999378007602 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 999378007603 active site 999378007604 catalytic tetrad [active] 999378007605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 999378007606 Methyltransferase domain; Region: Methyltransf_23; pfam13489 999378007607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999378007608 S-adenosylmethionine binding site [chemical binding]; other site 999378007609 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 999378007610 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 999378007611 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 999378007612 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 999378007613 Repair protein; Region: Repair_PSII; pfam04536 999378007614 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 999378007615 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 999378007616 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 999378007617 active site 999378007618 HIGH motif; other site 999378007619 dimer interface [polypeptide binding]; other site 999378007620 KMSKS motif; other site 999378007621 FtsX-like permease family; Region: FtsX; pfam02687 999378007622 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 999378007623 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 999378007624 Walker A/P-loop; other site 999378007625 ATP binding site [chemical binding]; other site 999378007626 Q-loop/lid; other site 999378007627 ABC transporter signature motif; other site 999378007628 Walker B; other site 999378007629 D-loop; other site 999378007630 H-loop/switch region; other site 999378007631 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 999378007632 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 999378007633 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 999378007634 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 999378007635 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378007636 Walker A/P-loop; other site 999378007637 ATP binding site [chemical binding]; other site 999378007638 Q-loop/lid; other site 999378007639 ABC transporter signature motif; other site 999378007640 Walker B; other site 999378007641 D-loop; other site 999378007642 H-loop/switch region; other site 999378007643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378007644 conserved gate region; other site 999378007645 ABC-ATPase subunit interface; other site 999378007646 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 999378007647 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 999378007648 Part of AAA domain; Region: AAA_19; pfam13245 999378007649 Family description; Region: UvrD_C_2; pfam13538 999378007650 Transcriptional regulator [Transcription]; Region: LysR; COG0583 999378007651 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 999378007652 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 999378007653 dimerization interface [polypeptide binding]; other site 999378007654 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 999378007655 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 999378007656 gating phenylalanine in ion channel; other site 999378007657 CAAX protease self-immunity; Region: Abi; pfam02517 999378007658 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 999378007659 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 999378007660 Zn2+ binding site [ion binding]; other site 999378007661 Mg2+ binding site [ion binding]; other site 999378007662 Transcriptional regulators [Transcription]; Region: MarR; COG1846 999378007663 MarR family; Region: MarR; pfam01047 999378007664 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378007665 Walker A/P-loop; other site 999378007666 ATP binding site [chemical binding]; other site 999378007667 Q-loop/lid; other site 999378007668 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 999378007669 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 999378007670 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378007671 ABC transporter signature motif; other site 999378007672 Walker B; other site 999378007673 D-loop; other site 999378007674 H-loop/switch region; other site 999378007675 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378007676 Walker A/P-loop; other site 999378007677 ATP binding site [chemical binding]; other site 999378007678 Q-loop/lid; other site 999378007679 ABC transporter signature motif; other site 999378007680 Walker B; other site 999378007681 D-loop; other site 999378007682 H-loop/switch region; other site 999378007683 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 999378007684 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 999378007685 active site 999378007686 catalytic tetrad [active] 999378007687 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 999378007688 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378007689 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 999378007690 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 999378007691 catalytic core [active] 999378007692 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 999378007693 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378007694 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 999378007695 active site 999378007696 motif I; other site 999378007697 motif II; other site 999378007698 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 999378007699 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 999378007700 RNA/DNA hybrid binding site [nucleotide binding]; other site 999378007701 active site 999378007702 Transcriptional regulator [Transcription]; Region: LysR; COG0583 999378007703 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 999378007704 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 999378007705 dimerization interface [polypeptide binding]; other site 999378007706 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 999378007707 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 999378007708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999378007709 homodimer interface [polypeptide binding]; other site 999378007710 catalytic residue [active] 999378007711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378007712 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999378007713 putative substrate translocation pore; other site 999378007714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378007715 putative substrate translocation pore; other site 999378007716 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 999378007717 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999378007718 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 999378007719 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 999378007720 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 999378007721 hexamer interface [polypeptide binding]; other site 999378007722 Walker A motif; other site 999378007723 ATP binding site [chemical binding]; other site 999378007724 Walker B motif; other site 999378007725 Protein of unknown function (DUF554); Region: DUF554; pfam04474 999378007726 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 999378007727 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 999378007728 active site 999378007729 P-loop; other site 999378007730 phosphorylation site [posttranslational modification] 999378007731 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 999378007732 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 999378007733 active site 999378007734 phosphorylation site [posttranslational modification] 999378007735 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 999378007736 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 999378007737 putative substrate binding site [chemical binding]; other site 999378007738 putative ATP binding site [chemical binding]; other site 999378007739 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 999378007740 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 999378007741 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 999378007742 putative active site [active] 999378007743 glycerol kinase; Provisional; Region: glpK; PRK00047 999378007744 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 999378007745 N- and C-terminal domain interface [polypeptide binding]; other site 999378007746 active site 999378007747 MgATP binding site [chemical binding]; other site 999378007748 catalytic site [active] 999378007749 metal binding site [ion binding]; metal-binding site 999378007750 glycerol binding site [chemical binding]; other site 999378007751 homotetramer interface [polypeptide binding]; other site 999378007752 homodimer interface [polypeptide binding]; other site 999378007753 FBP binding site [chemical binding]; other site 999378007754 protein IIAGlc interface [polypeptide binding]; other site 999378007755 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 999378007756 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999378007757 DNA-binding site [nucleotide binding]; DNA binding site 999378007758 UTRA domain; Region: UTRA; cl17743 999378007759 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 999378007760 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 999378007761 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 999378007762 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 999378007763 active pocket/dimerization site; other site 999378007764 active site 999378007765 phosphorylation site [posttranslational modification] 999378007766 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 999378007767 active site 999378007768 phosphorylation site [posttranslational modification] 999378007769 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 999378007770 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 999378007771 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 999378007772 active site 999378007773 methionine cluster; other site 999378007774 phosphorylation site [posttranslational modification] 999378007775 metal binding site [ion binding]; metal-binding site 999378007776 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 999378007777 active site 999378007778 P-loop; other site 999378007779 phosphorylation site [posttranslational modification] 999378007780 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 999378007781 beta-galactosidase; Region: BGL; TIGR03356 999378007782 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 999378007783 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 999378007784 nucleotide binding site [chemical binding]; other site 999378007785 Uncharacterized conserved protein [Function unknown]; Region: COG3538 999378007786 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 999378007787 alpha-mannosidase; Provisional; Region: PRK09819 999378007788 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 999378007789 active site 999378007790 metal binding site [ion binding]; metal-binding site 999378007791 catalytic site [active] 999378007792 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 999378007793 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 999378007794 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 999378007795 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 999378007796 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999378007797 DNA-binding site [nucleotide binding]; DNA binding site 999378007798 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 999378007799 hypothetical protein; Provisional; Region: PRK06357 999378007800 intersubunit interface [polypeptide binding]; other site 999378007801 active site 999378007802 Zn2+ binding site [ion binding]; other site 999378007803 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 999378007804 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 999378007805 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 999378007806 active site 999378007807 P-loop; other site 999378007808 phosphorylation site [posttranslational modification] 999378007809 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 999378007810 active site 999378007811 phosphorylation site [posttranslational modification] 999378007812 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 999378007813 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 999378007814 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 999378007815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999378007816 S-adenosylmethionine binding site [chemical binding]; other site 999378007817 Methyltransferase domain; Region: Methyltransf_31; pfam13847 999378007818 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 999378007819 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 999378007820 Ca binding site [ion binding]; other site 999378007821 active site 999378007822 catalytic site [active] 999378007823 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 999378007824 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 999378007825 Preprotein translocase subunit; Region: YajC; pfam02699 999378007826 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 999378007827 active pocket/dimerization site; other site 999378007828 active site 999378007829 phosphorylation site [posttranslational modification] 999378007830 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 999378007831 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 999378007832 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 999378007833 active site 999378007834 phosphorylation site [posttranslational modification] 999378007835 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 999378007836 Transcriptional regulator [Transcription]; Region: IclR; COG1414 999378007837 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 999378007838 Bacterial transcriptional regulator; Region: IclR; pfam01614 999378007839 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 999378007840 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 999378007841 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 999378007842 NADP binding site [chemical binding]; other site 999378007843 homodimer interface [polypeptide binding]; other site 999378007844 active site 999378007845 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 999378007846 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 999378007847 active site 999378007848 intersubunit interface [polypeptide binding]; other site 999378007849 catalytic residue [active] 999378007850 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 999378007851 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 999378007852 substrate binding site [chemical binding]; other site 999378007853 ATP binding site [chemical binding]; other site 999378007854 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 999378007855 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 999378007856 active site 999378007857 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 999378007858 tetramer (dimer of dimers) interface [polypeptide binding]; other site 999378007859 active site 999378007860 dimer interface [polypeptide binding]; other site 999378007861 conserved hypothetical integral membrane protein; Region: TIGR03766 999378007862 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 999378007863 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 999378007864 Ligand binding site; other site 999378007865 Putative Catalytic site; other site 999378007866 DXD motif; other site 999378007867 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 999378007868 active site 999378007869 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 999378007870 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 999378007871 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 999378007872 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 999378007873 HAMP domain; Region: HAMP; pfam00672 999378007874 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 999378007875 dimer interface [polypeptide binding]; other site 999378007876 phosphorylation site [posttranslational modification] 999378007877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999378007878 ATP binding site [chemical binding]; other site 999378007879 Mg2+ binding site [ion binding]; other site 999378007880 G-X-G motif; other site 999378007881 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 999378007882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999378007883 active site 999378007884 phosphorylation site [posttranslational modification] 999378007885 intermolecular recognition site; other site 999378007886 dimerization interface [polypeptide binding]; other site 999378007887 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 999378007888 DNA binding site [nucleotide binding] 999378007889 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 999378007890 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 999378007891 NAD binding site [chemical binding]; other site 999378007892 sugar binding site [chemical binding]; other site 999378007893 divalent metal binding site [ion binding]; other site 999378007894 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 999378007895 dimer interface [polypeptide binding]; other site 999378007896 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 999378007897 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 999378007898 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 999378007899 active site turn [active] 999378007900 phosphorylation site [posttranslational modification] 999378007901 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 999378007902 substrate binding site [chemical binding]; other site 999378007903 catalytic residues [active] 999378007904 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 999378007905 Helix-turn-helix domain; Region: HTH_38; pfam13936 999378007906 Integrase core domain; Region: rve; pfam00665 999378007907 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 999378007908 Mga helix-turn-helix domain; Region: Mga; pfam05043 999378007909 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 999378007910 Homeodomain-like domain; Region: HTH_23; cl17451 999378007911 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 999378007912 Transposase; Region: HTH_Tnp_1; cl17663 999378007913 Helix-turn-helix domain; Region: HTH_28; pfam13518 999378007914 putative transposase OrfB; Reviewed; Region: PHA02517 999378007915 HTH-like domain; Region: HTH_21; pfam13276 999378007916 Integrase core domain; Region: rve; pfam00665 999378007917 Integrase core domain; Region: rve_3; pfam13683 999378007918 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 999378007919 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 999378007920 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 999378007921 putative active site [active] 999378007922 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 999378007923 HPr interaction site; other site 999378007924 glycerol kinase (GK) interaction site [polypeptide binding]; other site 999378007925 active site 999378007926 phosphorylation site [posttranslational modification] 999378007927 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 999378007928 Uncharacterized conserved protein [Function unknown]; Region: COG1434 999378007929 putative active site [active] 999378007930 Protein of unknown function (DUF1341); Region: DUF1341; pfam07071 999378007931 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 999378007932 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 999378007933 dihydroorotase; Provisional; Region: PRK09237 999378007934 active site 999378007935 Domain of unknown function (DUF4310); Region: DUF4310; pfam14187 999378007936 Domain of unknown function (DUF4311); Region: DUF4311; cl11919 999378007937 Domain of unknown function (DUF4312); Region: DUF4312; cl11917 999378007938 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 999378007939 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 999378007940 HTH domain; Region: HTH_11; pfam08279 999378007941 HTH domain; Region: HTH_11; pfam08279 999378007942 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 999378007943 active site 999378007944 P-loop; other site 999378007945 phosphorylation site [posttranslational modification] 999378007946 Class I aldolases; Region: Aldolase_Class_I; cl17187 999378007947 catalytic residue [active] 999378007948 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 999378007949 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 999378007950 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 999378007951 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 999378007952 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 999378007953 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 999378007954 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 999378007955 HTH domain; Region: HTH_11; pfam08279 999378007956 PRD domain; Region: PRD; pfam00874 999378007957 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 999378007958 active site 999378007959 phosphorylation site [posttranslational modification] 999378007960 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 999378007961 classical (c) SDRs; Region: SDR_c; cd05233 999378007962 NAD(P) binding site [chemical binding]; other site 999378007963 active site 999378007964 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 999378007965 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 999378007966 intersubunit interface [polypeptide binding]; other site 999378007967 active site 999378007968 Zn2+ binding site [ion binding]; other site 999378007969 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378007970 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 999378007971 active site 999378007972 motif I; other site 999378007973 motif II; other site 999378007974 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378007975 motif II; other site 999378007976 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 999378007977 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 999378007978 AP (apurinic/apyrimidinic) site pocket; other site 999378007979 DNA interaction; other site 999378007980 Metal-binding active site; metal-binding site 999378007981 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 999378007982 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 999378007983 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 999378007984 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 999378007985 active site 999378007986 dimer interface [polypeptide binding]; other site 999378007987 magnesium binding site [ion binding]; other site 999378007988 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 999378007989 active site 999378007990 P-loop; other site 999378007991 phosphorylation site [posttranslational modification] 999378007992 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 999378007993 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 999378007994 active site 999378007995 phosphorylation site [posttranslational modification] 999378007996 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 999378007997 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 999378007998 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 999378007999 tetramer (dimer of dimers) interface [polypeptide binding]; other site 999378008000 active site 999378008001 dimer interface [polypeptide binding]; other site 999378008002 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 999378008003 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 999378008004 NAD(P) binding site [chemical binding]; other site 999378008005 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 999378008006 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 999378008007 substrate binding site [chemical binding]; other site 999378008008 hexamer interface [polypeptide binding]; other site 999378008009 metal binding site [ion binding]; metal-binding site 999378008010 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 999378008011 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 999378008012 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 999378008013 active site 999378008014 phosphorylation site [posttranslational modification] 999378008015 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 999378008016 active pocket/dimerization site; other site 999378008017 active site 999378008018 phosphorylation site [posttranslational modification] 999378008019 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 999378008020 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 999378008021 NAD(P) binding site [chemical binding]; other site 999378008022 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 999378008023 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 999378008024 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 999378008025 putative phosphoketolase; Provisional; Region: PRK05261 999378008026 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 999378008027 TPP-binding site; other site 999378008028 XFP C-terminal domain; Region: XFP_C; pfam09363 999378008029 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 999378008030 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 999378008031 nucleotide binding site [chemical binding]; other site 999378008032 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 999378008033 active site 999378008034 dimer interface [polypeptide binding]; other site 999378008035 catalytic nucleophile [active] 999378008036 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 999378008037 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 999378008038 active site 999378008039 metal binding site [ion binding]; metal-binding site 999378008040 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 999378008041 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999378008042 DNA-binding site [nucleotide binding]; DNA binding site 999378008043 UTRA domain; Region: UTRA; pfam07702 999378008044 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 999378008045 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 999378008046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999378008047 homodimer interface [polypeptide binding]; other site 999378008048 catalytic residue [active] 999378008049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378008050 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999378008051 putative substrate translocation pore; other site 999378008052 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 999378008053 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 999378008054 D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK; cd07803 999378008055 N- and C-terminal domain interface [polypeptide binding]; other site 999378008056 D-xylulose kinase; Region: XylB; TIGR01312 999378008057 active site 999378008058 MgATP binding site [chemical binding]; other site 999378008059 catalytic site [active] 999378008060 metal binding site [ion binding]; metal-binding site 999378008061 xylulose binding site [chemical binding]; other site 999378008062 homodimer interface [polypeptide binding]; other site 999378008063 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 999378008064 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 999378008065 NAD(P) binding site [chemical binding]; other site 999378008066 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 999378008067 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 999378008068 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 999378008069 active site 999378008070 phosphorylation site [posttranslational modification] 999378008071 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 999378008072 active pocket/dimerization site; other site 999378008073 active site 999378008074 phosphorylation site [posttranslational modification] 999378008075 PRD domain; Region: PRD; pfam00874 999378008076 PRD domain; Region: PRD; pfam00874 999378008077 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 999378008078 active site 999378008079 P-loop; other site 999378008080 phosphorylation site [posttranslational modification] 999378008081 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 999378008082 active site 999378008083 phosphorylation site [posttranslational modification] 999378008084 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 999378008085 Helix-turn-helix domain; Region: HTH_38; pfam13936 999378008086 Integrase core domain; Region: rve; pfam00665 999378008087 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 999378008088 intersubunit interface [polypeptide binding]; other site 999378008089 active site 999378008090 zinc binding site [ion binding]; other site 999378008091 Na+ binding site [ion binding]; other site 999378008092 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 999378008093 putative N- and C-terminal domain interface [polypeptide binding]; other site 999378008094 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 999378008095 putative active site [active] 999378008096 putative MgATP binding site [chemical binding]; other site 999378008097 catalytic site [active] 999378008098 metal binding site [ion binding]; metal-binding site 999378008099 putative carbohydrate binding site [chemical binding]; other site 999378008100 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 999378008101 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 999378008102 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 999378008103 active site 999378008104 P-loop; other site 999378008105 phosphorylation site [posttranslational modification] 999378008106 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 999378008107 active site 999378008108 phosphorylation site [posttranslational modification] 999378008109 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 999378008110 intersubunit interface [polypeptide binding]; other site 999378008111 active site 999378008112 zinc binding site [ion binding]; other site 999378008113 Na+ binding site [ion binding]; other site 999378008114 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 999378008115 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999378008116 DNA-binding site [nucleotide binding]; DNA binding site 999378008117 UTRA domain; Region: UTRA; pfam07702 999378008118 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 999378008119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999378008120 Coenzyme A binding pocket [chemical binding]; other site 999378008121 Predicted transcriptional regulators [Transcription]; Region: COG1695 999378008122 Transcriptional regulator PadR-like family; Region: PadR; cl17335 999378008123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378008124 D-galactonate transporter; Region: 2A0114; TIGR00893 999378008125 putative substrate translocation pore; other site 999378008126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378008127 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 999378008128 Coenzyme A binding pocket [chemical binding]; other site 999378008129 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 999378008130 Isochorismatase family; Region: Isochorismatase; pfam00857 999378008131 catalytic triad [active] 999378008132 conserved cis-peptide bond; other site 999378008133 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 999378008134 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999378008135 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999378008136 non-specific DNA binding site [nucleotide binding]; other site 999378008137 salt bridge; other site 999378008138 sequence-specific DNA binding site [nucleotide binding]; other site 999378008139 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 999378008140 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 999378008141 active site 999378008142 catalytic site [active] 999378008143 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 999378008144 Low molecular weight phosphatase family; Region: LMWPc; cd00115 999378008145 active site 999378008146 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 999378008147 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 999378008148 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 999378008149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378008150 dimer interface [polypeptide binding]; other site 999378008151 conserved gate region; other site 999378008152 putative PBP binding loops; other site 999378008153 ABC-ATPase subunit interface; other site 999378008154 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 999378008155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378008156 dimer interface [polypeptide binding]; other site 999378008157 conserved gate region; other site 999378008158 putative PBP binding loops; other site 999378008159 ABC-ATPase subunit interface; other site 999378008160 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 999378008161 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999378008162 Walker A/P-loop; other site 999378008163 ATP binding site [chemical binding]; other site 999378008164 Q-loop/lid; other site 999378008165 ABC transporter signature motif; other site 999378008166 Walker B; other site 999378008167 D-loop; other site 999378008168 H-loop/switch region; other site 999378008169 TOBE domain; Region: TOBE_2; pfam08402 999378008170 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 999378008171 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 999378008172 active site 999378008173 Isochorismatase family; Region: Isochorismatase; pfam00857 999378008174 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 999378008175 catalytic triad [active] 999378008176 conserved cis-peptide bond; other site 999378008177 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 999378008178 nudix motif; other site 999378008179 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 999378008180 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 999378008181 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 999378008182 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 999378008183 active site 999378008184 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 999378008185 Beta-lactamase; Region: Beta-lactamase; pfam00144 999378008186 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 999378008187 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 999378008188 putative active site [active] 999378008189 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 999378008190 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 999378008191 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 999378008192 putative active site [active] 999378008193 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 999378008194 active site 999378008195 phosphorylation site [posttranslational modification] 999378008196 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 999378008197 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 999378008198 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 999378008199 putative phosphate binding site [ion binding]; other site 999378008200 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 999378008201 DHH family; Region: DHH; pfam01368 999378008202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 999378008203 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 999378008204 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 999378008205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999378008206 Coenzyme A binding pocket [chemical binding]; other site 999378008207 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 999378008208 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999378008209 Coenzyme A binding pocket [chemical binding]; other site 999378008210 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 999378008211 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378008212 active site 999378008213 motif I; other site 999378008214 motif II; other site 999378008215 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 999378008216 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 999378008217 putative NAD(P) binding site [chemical binding]; other site 999378008218 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 999378008219 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 999378008220 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 999378008221 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 999378008222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999378008223 Coenzyme A binding pocket [chemical binding]; other site 999378008224 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 999378008225 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999378008226 Coenzyme A binding pocket [chemical binding]; other site 999378008227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 999378008228 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 999378008229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999378008230 Coenzyme A binding pocket [chemical binding]; other site 999378008231 Divergent AAA domain; Region: AAA_4; pfam04326 999378008232 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 999378008233 Integrase core domain; Region: rve; pfam00665 999378008234 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 999378008235 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 999378008236 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 999378008237 transmembrane helices; other site 999378008238 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 999378008239 hypothetical protein; Provisional; Region: PRK06446 999378008240 metal binding site [ion binding]; metal-binding site 999378008241 dimer interface [polypeptide binding]; other site 999378008242 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 999378008243 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 999378008244 peptide binding site [polypeptide binding]; other site 999378008245 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 999378008246 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 999378008247 Soluble P-type ATPase [General function prediction only]; Region: COG4087 999378008248 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 999378008249 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 999378008250 putative dimer interface [polypeptide binding]; other site 999378008251 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 999378008252 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 999378008253 protein binding site [polypeptide binding]; other site 999378008254 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 999378008255 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 999378008256 YycH protein; Region: YycI; pfam09648 999378008257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 999378008258 YycH protein; Region: YycH; pfam07435 999378008259 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 999378008260 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 999378008261 dimerization interface [polypeptide binding]; other site 999378008262 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 999378008263 putative active site [active] 999378008264 heme pocket [chemical binding]; other site 999378008265 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 999378008266 dimer interface [polypeptide binding]; other site 999378008267 phosphorylation site [posttranslational modification] 999378008268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999378008269 ATP binding site [chemical binding]; other site 999378008270 Mg2+ binding site [ion binding]; other site 999378008271 G-X-G motif; other site 999378008272 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 999378008273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999378008274 active site 999378008275 phosphorylation site [posttranslational modification] 999378008276 intermolecular recognition site; other site 999378008277 dimerization interface [polypeptide binding]; other site 999378008278 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 999378008279 DNA binding site [nucleotide binding] 999378008280 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 999378008281 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 999378008282 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 999378008283 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 999378008284 substrate binding pocket [chemical binding]; other site 999378008285 membrane-bound complex binding site; other site 999378008286 hinge residues; other site 999378008287 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 999378008288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378008289 dimer interface [polypeptide binding]; other site 999378008290 conserved gate region; other site 999378008291 putative PBP binding loops; other site 999378008292 ABC-ATPase subunit interface; other site 999378008293 argininosuccinate synthase; Provisional; Region: PRK13820 999378008294 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 999378008295 ANP binding site [chemical binding]; other site 999378008296 Substrate Binding Site II [chemical binding]; other site 999378008297 Substrate Binding Site I [chemical binding]; other site 999378008298 argininosuccinate lyase; Provisional; Region: PRK00855 999378008299 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 999378008300 active sites [active] 999378008301 tetramer interface [polypeptide binding]; other site 999378008302 Uncharacterized conserved protein [Function unknown]; Region: COG3589 999378008303 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 999378008304 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 999378008305 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 999378008306 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 999378008307 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 999378008308 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999378008309 DNA-binding site [nucleotide binding]; DNA binding site 999378008310 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 999378008311 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 999378008312 active site 999378008313 P-loop; other site 999378008314 phosphorylation site [posttranslational modification] 999378008315 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 999378008316 active site 999378008317 methionine cluster; other site 999378008318 phosphorylation site [posttranslational modification] 999378008319 metal binding site [ion binding]; metal-binding site 999378008320 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 999378008321 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 999378008322 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 999378008323 nudix motif; other site 999378008324 hypothetical protein; Provisional; Region: PRK06762 999378008325 AAA domain; Region: AAA_33; pfam13671 999378008326 Isochorismatase family; Region: Isochorismatase; pfam00857 999378008327 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 999378008328 catalytic triad [active] 999378008329 dimer interface [polypeptide binding]; other site 999378008330 conserved cis-peptide bond; other site 999378008331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378008332 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999378008333 putative substrate translocation pore; other site 999378008334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378008335 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 999378008336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378008337 putative substrate translocation pore; other site 999378008338 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 999378008339 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 999378008340 active site 999378008341 catalytic tetrad [active] 999378008342 Domain of unknown function (DUF956); Region: DUF956; pfam06115 999378008343 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 999378008344 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 999378008345 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 999378008346 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 999378008347 active pocket/dimerization site; other site 999378008348 active site 999378008349 phosphorylation site [posttranslational modification] 999378008350 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 999378008351 active site 999378008352 phosphorylation site [posttranslational modification] 999378008353 H+ Antiporter protein; Region: 2A0121; TIGR00900 999378008354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999378008355 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999378008356 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999378008357 non-specific DNA binding site [nucleotide binding]; other site 999378008358 salt bridge; other site 999378008359 sequence-specific DNA binding site [nucleotide binding]; other site 999378008360 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 999378008361 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999378008362 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999378008363 non-specific DNA binding site [nucleotide binding]; other site 999378008364 salt bridge; other site 999378008365 sequence-specific DNA binding site [nucleotide binding]; other site 999378008366 Helix-turn-helix domain; Region: HTH_19; pfam12844 999378008367 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 999378008368 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 999378008369 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 999378008370 substrate binding pocket [chemical binding]; other site 999378008371 membrane-bound complex binding site; other site 999378008372 hinge residues; other site 999378008373 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 999378008374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378008375 dimer interface [polypeptide binding]; other site 999378008376 conserved gate region; other site 999378008377 putative PBP binding loops; other site 999378008378 ABC-ATPase subunit interface; other site 999378008379 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 999378008380 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 999378008381 Walker A/P-loop; other site 999378008382 ATP binding site [chemical binding]; other site 999378008383 Q-loop/lid; other site 999378008384 ABC transporter signature motif; other site 999378008385 Walker B; other site 999378008386 D-loop; other site 999378008387 H-loop/switch region; other site 999378008388 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 999378008389 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 999378008390 Protein of unknown function (DUF975); Region: DUF975; cl10504 999378008391 Uncharacterized conserved protein [Function unknown]; Region: COG3402 999378008392 Predicted membrane protein [Function unknown]; Region: COG3428 999378008393 Bacterial PH domain; Region: DUF304; pfam03703 999378008394 Bacterial PH domain; Region: DUF304; pfam03703 999378008395 Bacterial PH domain; Region: DUF304; cl01348 999378008396 Predicted ATPase [General function prediction only]; Region: COG3910 999378008397 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 999378008398 Walker A/P-loop; other site 999378008399 ATP binding site [chemical binding]; other site 999378008400 Q-loop/lid; other site 999378008401 ABC transporter signature motif; other site 999378008402 Walker B; other site 999378008403 D-loop; other site 999378008404 H-loop/switch region; other site 999378008405 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 999378008406 Phosphotransferase enzyme family; Region: APH; pfam01636 999378008407 active site 999378008408 ATP binding site [chemical binding]; other site 999378008409 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 999378008410 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 999378008411 Walker A/P-loop; other site 999378008412 ATP binding site [chemical binding]; other site 999378008413 Q-loop/lid; other site 999378008414 ABC transporter signature motif; other site 999378008415 Walker B; other site 999378008416 D-loop; other site 999378008417 H-loop/switch region; other site 999378008418 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 999378008419 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 999378008420 substrate binding pocket [chemical binding]; other site 999378008421 membrane-bound complex binding site; other site 999378008422 hinge residues; other site 999378008423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378008424 dimer interface [polypeptide binding]; other site 999378008425 conserved gate region; other site 999378008426 putative PBP binding loops; other site 999378008427 ABC-ATPase subunit interface; other site 999378008428 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 999378008429 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 999378008430 substrate binding pocket [chemical binding]; other site 999378008431 membrane-bound complex binding site; other site 999378008432 hinge residues; other site 999378008433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999378008434 dimer interface [polypeptide binding]; other site 999378008435 conserved gate region; other site 999378008436 putative PBP binding loops; other site 999378008437 ABC-ATPase subunit interface; other site 999378008438 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 999378008439 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 999378008440 Integral membrane protein DUF95; Region: DUF95; pfam01944 999378008441 MoxR-like ATPases [General function prediction only]; Region: COG0714 999378008442 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999378008443 Walker A motif; other site 999378008444 ATP binding site [chemical binding]; other site 999378008445 Walker B motif; other site 999378008446 MoxR-like ATPases [General function prediction only]; Region: COG0714 999378008447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 999378008448 Protein of unknown function DUF58; Region: DUF58; pfam01882 999378008449 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 999378008450 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 999378008451 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 999378008452 putative ADP-binding pocket [chemical binding]; other site 999378008453 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 999378008454 maltose O-acetyltransferase; Provisional; Region: PRK10092 999378008455 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 999378008456 active site 999378008457 substrate binding site [chemical binding]; other site 999378008458 trimer interface [polypeptide binding]; other site 999378008459 CoA binding site [chemical binding]; other site 999378008460 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378008461 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 999378008462 active site 999378008463 motif I; other site 999378008464 motif II; other site 999378008465 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378008466 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 999378008467 Aspartase; Region: Aspartase; cd01357 999378008468 active sites [active] 999378008469 tetramer interface [polypeptide binding]; other site 999378008470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 999378008471 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 999378008472 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 999378008473 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 999378008474 Malic enzyme, N-terminal domain; Region: malic; pfam00390 999378008475 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 999378008476 putative NAD(P) binding site [chemical binding]; other site 999378008477 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 999378008478 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 999378008479 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 999378008480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999378008481 active site 999378008482 phosphorylation site [posttranslational modification] 999378008483 intermolecular recognition site; other site 999378008484 dimerization interface [polypeptide binding]; other site 999378008485 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 999378008486 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 999378008487 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 999378008488 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 999378008489 Agrin NtA domain; Region: NtA; pfam03146 999378008490 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 999378008491 Int/Topo IB signature motif; other site 999378008492 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999378008493 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999378008494 non-specific DNA binding site [nucleotide binding]; other site 999378008495 salt bridge; other site 999378008496 sequence-specific DNA binding site [nucleotide binding]; other site 999378008497 Helix-turn-helix domain; Region: HTH_17; pfam12728 999378008498 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 999378008499 polymerase nucleotide-binding site; other site 999378008500 DNA-binding residues [nucleotide binding]; DNA binding site 999378008501 nucleotide binding site [chemical binding]; other site 999378008502 primase nucleotide-binding site [nucleotide binding]; other site 999378008503 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 999378008504 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 999378008505 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 999378008506 Phage terminase, small subunit; Region: Terminase_4; pfam05119 999378008507 Phage Terminase; Region: Terminase_1; pfam03354 999378008508 Phage portal protein; Region: Phage_portal; pfam04860 999378008509 Phage-related protein [Function unknown]; Region: COG4695; cl01923 999378008510 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 999378008511 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 999378008512 Phage capsid family; Region: Phage_capsid; pfam05065 999378008513 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 999378008514 oligomerization interface [polypeptide binding]; other site 999378008515 Predicted membrane protein [Function unknown]; Region: COG2261 999378008516 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 999378008517 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 999378008518 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 999378008519 active site 999378008520 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 999378008521 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 999378008522 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 999378008523 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 999378008524 substrate binding pocket [chemical binding]; other site 999378008525 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 999378008526 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 999378008527 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 999378008528 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 999378008529 active site 999378008530 phosphorylation site [posttranslational modification] 999378008531 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 999378008532 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 999378008533 Mga helix-turn-helix domain; Region: Mga; pfam05043 999378008534 DNA-binding interface [nucleotide binding]; DNA binding site 999378008535 PRD domain; Region: PRD; pfam00874 999378008536 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 999378008537 active site 999378008538 P-loop; other site 999378008539 phosphorylation site [posttranslational modification] 999378008540 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 999378008541 active site 999378008542 phosphorylation site [posttranslational modification] 999378008543 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 999378008544 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 999378008545 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 999378008546 active site 999378008547 P-loop; other site 999378008548 phosphorylation site [posttranslational modification] 999378008549 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 999378008550 active site 999378008551 P-loop; other site 999378008552 phosphorylation site [posttranslational modification] 999378008553 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 999378008554 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 999378008555 active site 999378008556 trimer interface [polypeptide binding]; other site 999378008557 allosteric site; other site 999378008558 active site lid [active] 999378008559 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999378008560 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 999378008561 active site 999378008562 motif I; other site 999378008563 motif II; other site 999378008564 HlyD family secretion protein; Region: HlyD_2; pfam12700 999378008565 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 999378008566 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 999378008567 Walker A/P-loop; other site 999378008568 ATP binding site [chemical binding]; other site 999378008569 Q-loop/lid; other site 999378008570 ABC transporter signature motif; other site 999378008571 Walker B; other site 999378008572 D-loop; other site 999378008573 H-loop/switch region; other site 999378008574 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 999378008575 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 999378008576 FtsX-like permease family; Region: FtsX; pfam02687 999378008577 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 999378008578 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 999378008579 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 999378008580 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 999378008581 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 999378008582 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 999378008583 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 999378008584 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 999378008585 putative active site [active] 999378008586 metal binding site [ion binding]; metal-binding site 999378008587 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 999378008588 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 999378008589 metal binding site [ion binding]; metal-binding site 999378008590 dimer interface [polypeptide binding]; other site 999378008591 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 999378008592 Uncharacterized conserved protein [Function unknown]; Region: COG2966 999378008593 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 999378008594 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 999378008595 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 999378008596 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 999378008597 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 999378008598 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 999378008599 trmE is a tRNA modification GTPase; Region: trmE; cd04164 999378008600 G1 box; other site 999378008601 GTP/Mg2+ binding site [chemical binding]; other site 999378008602 Switch I region; other site 999378008603 G2 box; other site 999378008604 Switch II region; other site 999378008605 G3 box; other site 999378008606 G4 box; other site 999378008607 G5 box; other site 999378008608 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 999378008609 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 999378008610 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 999378008611 G-X-X-G motif; other site 999378008612 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 999378008613 RxxxH motif; other site 999378008614 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 999378008615 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 999378008616 ribonuclease P; Reviewed; Region: rnpA; PRK00499 999378008617 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 999378008618 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 999378008619 Dimer interface [polypeptide binding]; other site 999378008620 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 999378008621 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 999378008622 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 999378008623 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 999378008624 active site 999378008625 CAT RNA binding domain; Region: CAT_RBD; pfam03123 999378008626 transcriptional antiterminator BglG; Provisional; Region: PRK09772 999378008627 PRD domain; Region: PRD; pfam00874 999378008628 PRD domain; Region: PRD; pfam00874 999378008629 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 999378008630 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 999378008631 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 999378008632 active site 999378008633 P-loop; other site 999378008634 phosphorylation site [posttranslational modification] 999378008635 6-phospho-beta-galactosidase; Region: lacG; TIGR01233 999378008636 beta-galactosidase; Region: BGL; TIGR03356 999378008637 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 999378008638 methionine cluster; other site 999378008639 active site 999378008640 phosphorylation site [posttranslational modification] 999378008641 metal binding site [ion binding]; metal-binding site 999378008642 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 999378008643 Transposase; Region: DDE_Tnp_ISL3; pfam01610 999378008644 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 999378008645 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 999378008646 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 999378008647 trimer interface [polypeptide binding]; other site 999378008648 active site 999378008649 substrate binding site [chemical binding]; other site 999378008650 CoA binding site [chemical binding]; other site 999378008651 cystathionine beta-lyase; Provisional; Region: PRK07671 999378008652 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 999378008653 homodimer interface [polypeptide binding]; other site 999378008654 substrate-cofactor binding pocket; other site 999378008655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999378008656 catalytic residue [active] 999378008657 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 999378008658 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 999378008659 dimer interface [polypeptide binding]; other site 999378008660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999378008661 catalytic residue [active] 999378008662 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 999378008663 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 999378008664 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 999378008665 ATP binding site [chemical binding]; other site 999378008666 putative Mg++ binding site [ion binding]; other site 999378008667 HsdM N-terminal domain; Region: HsdM_N; pfam12161 999378008668 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 999378008669 Methyltransferase domain; Region: Methyltransf_26; pfam13659 999378008670 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 999378008671 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 999378008672 Pleckstrin homology-like domain; Region: PH-like; cl17171 999378008673 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 999378008674 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 999378008675 Integrase core domain; Region: rve; pfam00665 999378008676 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 999378008677 AAA domain; Region: AAA_31; pfam13614 999378008678 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 999378008679 P-loop; other site 999378008680 Magnesium ion binding site [ion binding]; other site 999378008681 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 999378008682 Magnesium ion binding site [ion binding]; other site 999378008683 DNA polymerase IV; Reviewed; Region: PRK03103 999378008684 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 999378008685 active site 999378008686 DNA binding site [nucleotide binding] 999378008687 putative transposase OrfB; Reviewed; Region: PHA02517 999378008688 HTH-like domain; Region: HTH_21; pfam13276 999378008689 Integrase core domain; Region: rve; pfam00665 999378008690 Integrase core domain; Region: rve_3; pfam13683 999378008691 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 999378008692 Transposase; Region: HTH_Tnp_1; pfam01527 999378008693 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 999378008694 Collagen binding domain; Region: Collagen_bind; pfam05737 999378008695 Collagen binding domain; Region: Collagen_bind; pfam05737 999378008696 Collagen binding domain; Region: Collagen_bind; pfam05737 999378008697 Collagen binding domain; Region: Collagen_bind; pfam05737 999378008698 Cna protein B-type domain; Region: Cna_B; pfam05738 999378008699 Cna protein B-type domain; Region: Cna_B; pfam05738 999378008700 Cna protein B-type domain; Region: Cna_B; pfam05738 999378008701 Cna protein B-type domain; Region: Cna_B; pfam05738 999378008702 Cna protein B-type domain; Region: Cna_B; pfam05738 999378008703 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 999378008704 Transposase; Region: HTH_Tnp_1; pfam01527 999378008705 HTH-like domain; Region: HTH_21; pfam13276 999378008706 Integrase core domain; Region: rve; pfam00665 999378008707 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 999378008708 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257