-- dump date   	20140619_123008
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1215914000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1215914000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1215914000003	Walker A motif; other site
1215914000004	ATP binding site [chemical binding]; other site
1215914000005	Walker B motif; other site
1215914000006	arginine finger; other site
1215914000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1215914000008	DnaA box-binding interface [nucleotide binding]; other site
1215914000009	DNA polymerase III subunit beta; Validated; Region: PRK05643
1215914000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1215914000011	putative DNA binding surface [nucleotide binding]; other site
1215914000012	dimer interface [polypeptide binding]; other site
1215914000013	beta-clamp/clamp loader binding surface; other site
1215914000014	beta-clamp/translesion DNA polymerase binding surface; other site
1215914000015	S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501
1215914000016	recombination protein F; Reviewed; Region: recF; PRK00064
1215914000017	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1215914000018	Walker A/P-loop; other site
1215914000019	ATP binding site [chemical binding]; other site
1215914000020	Q-loop/lid; other site
1215914000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914000022	ABC transporter signature motif; other site
1215914000023	Walker B; other site
1215914000024	D-loop; other site
1215914000025	H-loop/switch region; other site
1215914000026	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1215914000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1215914000028	Mg2+ binding site [ion binding]; other site
1215914000029	G-X-G motif; other site
1215914000030	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1215914000031	anchoring element; other site
1215914000032	dimer interface [polypeptide binding]; other site
1215914000033	ATP binding site [chemical binding]; other site
1215914000034	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1215914000035	active site
1215914000036	metal binding site [ion binding]; metal-binding site
1215914000037	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1215914000038	DNA gyrase subunit A; Validated; Region: PRK05560
1215914000039	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1215914000040	CAP-like domain; other site
1215914000041	active site
1215914000042	primary dimer interface [polypeptide binding]; other site
1215914000043	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1215914000044	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1215914000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1215914000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1215914000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1215914000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1215914000049	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1215914000050	intersubunit interface [polypeptide binding]; other site
1215914000051	active site
1215914000052	catalytic residue [active]
1215914000053	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1215914000054	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1215914000055	dimer interface [polypeptide binding]; other site
1215914000056	ssDNA binding site [nucleotide binding]; other site
1215914000057	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1215914000058	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1215914000059	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1215914000060	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1215914000061	dimer interface [polypeptide binding]; other site
1215914000062	ssDNA binding site [nucleotide binding]; other site
1215914000063	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1215914000064	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1215914000065	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1215914000066	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1215914000067	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
1215914000068	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1215914000069	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1215914000070	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1215914000071	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
1215914000072	CAAX protease self-immunity; Region: Abi; pfam02517
1215914000073	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
1215914000074	Surface antigen [General function prediction only]; Region: COG3942
1215914000075	CHAP domain; Region: CHAP; pfam05257
1215914000076	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1215914000077	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1215914000078	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1215914000079	FtsX-like permease family; Region: FtsX; pfam02687
1215914000080	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1215914000081	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1215914000082	Walker A/P-loop; other site
1215914000083	ATP binding site [chemical binding]; other site
1215914000084	Q-loop/lid; other site
1215914000085	ABC transporter signature motif; other site
1215914000086	Walker B; other site
1215914000087	D-loop; other site
1215914000088	H-loop/switch region; other site
1215914000089	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1215914000090	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1215914000091	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1215914000092	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1215914000093	active site
1215914000094	motif I; other site
1215914000095	motif II; other site
1215914000096	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1215914000097	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1215914000098	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1215914000099	BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418
1215914000100	active site
1215914000101	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
1215914000102	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1215914000103	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
1215914000104	Cl binding site [ion binding]; other site
1215914000105	oligomer interface [polypeptide binding]; other site
1215914000106	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1215914000107	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1215914000108	manganese transport protein MntH; Reviewed; Region: PRK00701
1215914000109	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1215914000110	Peptidase family C69; Region: Peptidase_C69; pfam03577
1215914000111	Enterocin A Immunity; Region: EntA_Immun; pfam08951
1215914000112	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1215914000113	Predicted membrane protein [Function unknown]; Region: COG4392
1215914000114	CAAX protease self-immunity; Region: Abi; pfam02517
1215914000115	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
1215914000116	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1215914000117	active site
1215914000118	intersubunit interface [polypeptide binding]; other site
1215914000119	catalytic residue [active]
1215914000120	Transposase domain (DUF772); Region: DUF772; pfam05598
1215914000121	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1215914000122	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1215914000123	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1215914000124	DNA-binding site [nucleotide binding]; DNA binding site
1215914000125	FCD domain; Region: FCD; pfam07729
1215914000126	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1215914000127	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914000128	non-specific DNA binding site [nucleotide binding]; other site
1215914000129	salt bridge; other site
1215914000130	sequence-specific DNA binding site [nucleotide binding]; other site
1215914000131	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
1215914000132	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
1215914000133	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1215914000134	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1215914000135	Walker A/P-loop; other site
1215914000136	ATP binding site [chemical binding]; other site
1215914000137	Q-loop/lid; other site
1215914000138	ABC transporter signature motif; other site
1215914000139	Walker B; other site
1215914000140	D-loop; other site
1215914000141	H-loop/switch region; other site
1215914000142	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914000143	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1215914000144	putative substrate translocation pore; other site
1215914000145	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914000146	Predicted membrane protein [General function prediction only]; Region: COG4194
1215914000147	MMPL family; Region: MMPL; pfam03176
1215914000148	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1215914000149	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1215914000150	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1215914000151	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1215914000152	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914000153	putative PBP binding loops; other site
1215914000154	dimer interface [polypeptide binding]; other site
1215914000155	ABC-ATPase subunit interface; other site
1215914000156	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1215914000157	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1215914000158	glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186
1215914000159	Walker A/P-loop; other site
1215914000160	ATP binding site [chemical binding]; other site
1215914000161	Q-loop/lid; other site
1215914000162	ABC transporter signature motif; other site
1215914000163	Walker B; other site
1215914000164	D-loop; other site
1215914000165	H-loop/switch region; other site
1215914000166	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
1215914000167	CAAX protease self-immunity; Region: Abi; pfam02517
1215914000168	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
1215914000169	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1215914000170	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1215914000171	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1215914000172	metal-binding site [ion binding]
1215914000173	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1215914000174	dinuclear metal binding motif [ion binding]; other site
1215914000175	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1215914000176	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1215914000177	ligand binding site [chemical binding]; other site
1215914000178	flexible hinge region; other site
1215914000179	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1215914000180	putative switch regulator; other site
1215914000181	non-specific DNA interactions [nucleotide binding]; other site
1215914000182	DNA binding site [nucleotide binding]
1215914000183	sequence specific DNA binding site [nucleotide binding]; other site
1215914000184	putative cAMP binding site [chemical binding]; other site
1215914000185	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1215914000186	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1215914000187	substrate binding site [chemical binding]; other site
1215914000188	active site
1215914000189	catalytic residues [active]
1215914000190	heterodimer interface [polypeptide binding]; other site
1215914000191	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1215914000192	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1215914000193	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1215914000194	catalytic residue [active]
1215914000195	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1215914000196	active site
1215914000197	ribulose/triose binding site [chemical binding]; other site
1215914000198	phosphate binding site [ion binding]; other site
1215914000199	substrate (anthranilate) binding pocket [chemical binding]; other site
1215914000200	product (indole) binding pocket [chemical binding]; other site
1215914000201	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1215914000202	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1215914000203	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1215914000204	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
1215914000205	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
1215914000206	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1215914000207	active site
1215914000208	P-loop; other site
1215914000209	phosphorylation site [posttranslational modification]
1215914000210	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1215914000211	active site
1215914000212	phosphorylation site [posttranslational modification]
1215914000213	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914000214	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1215914000215	putative substrate translocation pore; other site
1215914000216	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914000217	putative substrate translocation pore; other site
1215914000218	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1215914000219	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1215914000220	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
1215914000221	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1215914000222	Walker A/P-loop; other site
1215914000223	ATP binding site [chemical binding]; other site
1215914000224	Q-loop/lid; other site
1215914000225	ABC transporter signature motif; other site
1215914000226	Walker B; other site
1215914000227	D-loop; other site
1215914000228	H-loop/switch region; other site
1215914000229	PemK-like protein; Region: PemK; pfam02452
1215914000230	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
1215914000231	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1215914000232	BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418
1215914000233	active site
1215914000234	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1215914000235	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1215914000236	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1215914000237	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1215914000238	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1215914000239	dimer interface [polypeptide binding]; other site
1215914000240	active site
1215914000241	catalytic residue [active]
1215914000242	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1215914000243	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
1215914000244	metal binding site [ion binding]; metal-binding site
1215914000245	putative dimer interface [polypeptide binding]; other site
1215914000246	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1215914000247	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1215914000248	active site
1215914000249	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1215914000250	substrate binding site [chemical binding]; other site
1215914000251	catalytic residues [active]
1215914000252	dimer interface [polypeptide binding]; other site
1215914000253	aspartate kinase; Reviewed; Region: PRK09034
1215914000254	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
1215914000255	putative catalytic residues [active]
1215914000256	putative nucleotide binding site [chemical binding]; other site
1215914000257	putative aspartate binding site [chemical binding]; other site
1215914000258	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
1215914000259	allosteric regulatory residue; other site
1215914000260	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1215914000261	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1215914000262	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1215914000263	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1215914000264	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1215914000265	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1215914000266	EamA-like transporter family; Region: EamA; cl17759
1215914000267	PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417
1215914000268	catalytic residues [active]
1215914000269	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1215914000270	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1215914000271	DHH family; Region: DHH; pfam01368
1215914000272	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1215914000273	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1215914000274	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1215914000275	replicative DNA helicase; Provisional; Region: PRK05748
1215914000276	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1215914000277	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1215914000278	Walker A motif; other site
1215914000279	ATP binding site [chemical binding]; other site
1215914000280	Walker B motif; other site
1215914000281	DNA binding loops [nucleotide binding]
1215914000282	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1215914000283	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1215914000284	GDP-binding site [chemical binding]; other site
1215914000285	ACT binding site; other site
1215914000286	IMP binding site; other site
1215914000287	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
1215914000288	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1215914000289	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1215914000290	dimerization interface [polypeptide binding]; other site
1215914000291	putative DNA binding site [nucleotide binding]; other site
1215914000292	putative Zn2+ binding site [ion binding]; other site
1215914000293	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
1215914000294	plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647
1215914000295	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1215914000296	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
1215914000297	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1215914000298	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1215914000299	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1215914000300	dimerization interface [polypeptide binding]; other site
1215914000301	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1215914000302	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914000303	non-specific DNA binding site [nucleotide binding]; other site
1215914000304	salt bridge; other site
1215914000305	sequence-specific DNA binding site [nucleotide binding]; other site
1215914000306	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1215914000307	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1215914000308	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
1215914000309	Walker A/P-loop; other site
1215914000310	ATP binding site [chemical binding]; other site
1215914000311	Q-loop/lid; other site
1215914000312	ABC transporter signature motif; other site
1215914000313	Walker B; other site
1215914000314	D-loop; other site
1215914000315	H-loop/switch region; other site
1215914000316	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1215914000317	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1215914000318	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
1215914000319	ATP cone domain; Region: ATP-cone; pfam03477
1215914000320	Class III ribonucleotide reductase; Region: RNR_III; cd01675
1215914000321	effector binding site; other site
1215914000322	active site
1215914000323	Zn binding site [ion binding]; other site
1215914000324	glycine loop; other site
1215914000325	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1215914000326	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914000327	non-specific DNA binding site [nucleotide binding]; other site
1215914000328	salt bridge; other site
1215914000329	sequence-specific DNA binding site [nucleotide binding]; other site
1215914000330	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
1215914000331	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1215914000332	active site
1215914000333	metal binding site [ion binding]; metal-binding site
1215914000334	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1215914000335	FAD binding domain; Region: FAD_binding_4; pfam01565
1215914000336	Transposase domain (DUF772); Region: DUF772; pfam05598
1215914000337	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1215914000338	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
1215914000339	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
1215914000340	active site
1215914000341	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700
1215914000342	dimer interface [polypeptide binding]; other site
1215914000343	catalytic triad [active]
1215914000344	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700
1215914000345	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
1215914000346	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1215914000347	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1215914000348	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
1215914000349	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1215914000350	DNA binding site [nucleotide binding]
1215914000351	active site
1215914000352	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
1215914000353	D-lactate dehydrogenase; Validated; Region: PRK08605
1215914000354	homodimer interface [polypeptide binding]; other site
1215914000355	ligand binding site [chemical binding]; other site
1215914000356	NAD binding site [chemical binding]; other site
1215914000357	catalytic site [active]
1215914000358	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1215914000359	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1215914000360	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1215914000361	NAD(P) binding site [chemical binding]; other site
1215914000362	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
1215914000363	Protein of unknown function (DUF1516); Region: DUF1516; pfam07457
1215914000364	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1215914000365	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1215914000366	Helix-turn-helix domain; Region: HTH_38; pfam13936
1215914000367	Integrase core domain; Region: rve; pfam00665
1215914000368	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1215914000369	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1215914000370	Zn binding site [ion binding]; other site
1215914000371	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1215914000372	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1215914000373	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1215914000374	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1215914000375	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
1215914000376	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
1215914000377	Mga helix-turn-helix domain; Region: Mga; pfam05043
1215914000378	Protein of unknown function (DUF805); Region: DUF805; pfam05656
1215914000379	Protein of unknown function (DUF805); Region: DUF805; pfam05656
1215914000380	recombination factor protein RarA; Reviewed; Region: PRK13342
1215914000381	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1215914000382	Walker A motif; other site
1215914000383	ATP binding site [chemical binding]; other site
1215914000384	Walker B motif; other site
1215914000385	arginine finger; other site
1215914000386	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1215914000387	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1215914000388	propionate/acetate kinase; Provisional; Region: PRK12379
1215914000389	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
1215914000390	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1215914000391	active site
1215914000392	metal binding site [ion binding]; metal-binding site
1215914000393	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1215914000394	endonuclease III; Region: ENDO3c; smart00478
1215914000395	minor groove reading motif; other site
1215914000396	helix-hairpin-helix signature motif; other site
1215914000397	substrate binding pocket [chemical binding]; other site
1215914000398	active site
1215914000399	Domain of unknown function DUF77; Region: DUF77; pfam01910
1215914000400	Predicted membrane protein [Function unknown]; Region: COG1511
1215914000401	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1215914000402	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
1215914000403	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
1215914000404	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1215914000405	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1215914000406	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1215914000407	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914000408	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1215914000409	putative substrate translocation pore; other site
1215914000410	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914000411	putative phosphoketolase; Provisional; Region: PRK05261
1215914000412	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
1215914000413	TPP-binding site; other site
1215914000414	XFP C-terminal domain; Region: XFP_C; pfam09363
1215914000415	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1215914000416	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1215914000417	peptide binding site [polypeptide binding]; other site
1215914000418	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1215914000419	nudix motif; other site
1215914000420	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
1215914000421	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
1215914000422	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1215914000423	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1215914000424	Repair protein; Region: Repair_PSII; pfam04536
1215914000425	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1215914000426	Protein of unknown function (DUF1634); Region: DUF1634; pfam07843
1215914000427	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1215914000428	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
1215914000429	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1215914000430	putative ligand binding site [chemical binding]; other site
1215914000431	putative NAD binding site [chemical binding]; other site
1215914000432	catalytic site [active]
1215914000433	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1215914000434	Predicted membrane protein [Function unknown]; Region: COG2261
1215914000435	Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031
1215914000436	Asp23 family; Region: Asp23; pfam03780
1215914000437	Asp23 family; Region: Asp23; pfam03780
1215914000438	Protein of unknown function (DUF969); Region: DUF969; pfam06149
1215914000439	Predicted membrane protein [Function unknown]; Region: COG3817
1215914000440	Protein of unknown function (DUF979); Region: DUF979; pfam06166
1215914000441	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
1215914000442	putative substrate binding pocket [chemical binding]; other site
1215914000443	AC domain interface; other site
1215914000444	catalytic triad [active]
1215914000445	AB domain interface; other site
1215914000446	interchain disulfide; other site
1215914000447	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
1215914000448	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1215914000449	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1215914000450	catalytic triad [active]
1215914000451	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1215914000452	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1215914000453	S-adenosylmethionine binding site [chemical binding]; other site
1215914000454	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
1215914000455	ParB-like nuclease domain; Region: ParBc; pfam02195
1215914000456	KorB domain; Region: KorB; pfam08535
1215914000457	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1215914000458	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1215914000459	P-loop; other site
1215914000460	Magnesium ion binding site [ion binding]; other site
1215914000461	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1215914000462	Magnesium ion binding site [ion binding]; other site
1215914000463	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1215914000464	ParB-like nuclease domain; Region: ParB; smart00470
1215914000465	KorB domain; Region: KorB; pfam08535
1215914000466	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
1215914000467	GTP-binding protein YchF; Reviewed; Region: PRK09601
1215914000468	YchF GTPase; Region: YchF; cd01900
1215914000469	G1 box; other site
1215914000470	GTP/Mg2+ binding site [chemical binding]; other site
1215914000471	Switch I region; other site
1215914000472	G2 box; other site
1215914000473	Switch II region; other site
1215914000474	G3 box; other site
1215914000475	G4 box; other site
1215914000476	G5 box; other site
1215914000477	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1215914000478	Protein of unknown function (DUF1129); Region: DUF1129; pfam06570
1215914000479	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
1215914000480	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1215914000481	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1215914000482	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1215914000483	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1215914000484	active site
1215914000485	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1215914000486	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1215914000487	active site
1215914000488	phosphorylation site [posttranslational modification]
1215914000489	intermolecular recognition site; other site
1215914000490	dimerization interface [polypeptide binding]; other site
1215914000491	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1215914000492	DNA binding site [nucleotide binding]
1215914000493	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1215914000494	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1215914000495	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1215914000496	dimer interface [polypeptide binding]; other site
1215914000497	phosphorylation site [posttranslational modification]
1215914000498	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1215914000499	ATP binding site [chemical binding]; other site
1215914000500	Mg2+ binding site [ion binding]; other site
1215914000501	G-X-G motif; other site
1215914000502	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1215914000503	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1215914000504	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1215914000505	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1215914000506	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1215914000507	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1215914000508	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1215914000509	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1215914000510	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1215914000511	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1215914000512	aspartate racemase; Region: asp_race; TIGR00035
1215914000513	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1215914000514	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1215914000515	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1215914000516	active site
1215914000517	catalytic tetrad [active]
1215914000518	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1215914000519	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1215914000520	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1215914000521	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914000522	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1215914000523	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914000524	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1215914000525	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1215914000526	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1215914000527	NAD(P) binding site [chemical binding]; other site
1215914000528	catalytic residues [active]
1215914000529	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
1215914000530	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1215914000531	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1215914000532	substrate binding site [chemical binding]; other site
1215914000533	ATP binding site [chemical binding]; other site
1215914000534	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
1215914000535	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1215914000536	PYR/PP interface [polypeptide binding]; other site
1215914000537	dimer interface [polypeptide binding]; other site
1215914000538	TPP binding site [chemical binding]; other site
1215914000539	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1215914000540	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
1215914000541	TPP-binding site; other site
1215914000542	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1215914000543	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1215914000544	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1215914000545	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1215914000546	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1215914000547	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1215914000548	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1215914000549	Fructose-bisphosphate aldolase class-II; Region: F_bP_aldolase; pfam01116
1215914000550	active site
1215914000551	intersubunit interface [polypeptide binding]; other site
1215914000552	zinc binding site [ion binding]; other site
1215914000553	Na+ binding site [ion binding]; other site
1215914000554	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1215914000555	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1215914000556	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1215914000557	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1215914000558	putative active site [active]
1215914000559	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
1215914000560	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1215914000561	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
1215914000562	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
1215914000563	N- and C-terminal domain interface [polypeptide binding]; other site
1215914000564	active site
1215914000565	catalytic site [active]
1215914000566	metal binding site [ion binding]; metal-binding site
1215914000567	carbohydrate binding site [chemical binding]; other site
1215914000568	ATP binding site [chemical binding]; other site
1215914000569	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1215914000570	Citrate transporter; Region: CitMHS; pfam03600
1215914000571	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1215914000572	active site
1215914000573	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1215914000574	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1215914000575	active site
1215914000576	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1215914000577	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1215914000578	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1215914000579	active site
1215914000580	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
1215914000581	AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522
1215914000582	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1215914000583	active site
1215914000584	SH3-like domain; Region: SH3_8; pfam13457
1215914000585	SH3-like domain; Region: SH3_8; pfam13457
1215914000586	SH3-like domain; Region: SH3_8; pfam13457
1215914000587	SH3-like domain; Region: SH3_8; pfam13457
1215914000588	SH3-like domain; Region: SH3_8; pfam13457
1215914000589	SH3-like domain; Region: SH3_8; pfam13457
1215914000590	SH3-like domain; Region: SH3_8; pfam13457
1215914000591	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1215914000592	Polysaccharide biosynthesis protein; Region: Polysacc_synt; pfam01943
1215914000593	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1215914000594	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1215914000595	active site
1215914000596	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1215914000597	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1215914000598	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1215914000599	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1215914000600	putative PBP binding regions; other site
1215914000601	ABC-ATPase subunit  interface; other site
1215914000602	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1215914000603	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1215914000604	active site
1215914000605	metal binding site [ion binding]; metal-binding site
1215914000606	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1215914000607	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1215914000608	oligoendopeptidase F; Region: pepF; TIGR00181
1215914000609	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
1215914000610	active site
1215914000611	Zn binding site [ion binding]; other site
1215914000612	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1215914000613	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
1215914000614	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1215914000615	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1215914000616	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1215914000617	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1215914000618	active site
1215914000619	Protein of unknown function (DUF975); Region: DUF975; cl10504
1215914000620	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1215914000621	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1215914000622	Catalytic site [active]
1215914000623	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1215914000624	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
1215914000625	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1215914000626	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1215914000627	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1215914000628	ABC transporter; Region: ABC_tran_2; pfam12848
1215914000629	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1215914000630	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
1215914000631	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1215914000632	S-adenosylmethionine binding site [chemical binding]; other site
1215914000633	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1215914000634	catalytic residues [active]
1215914000635	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1215914000636	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1215914000637	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
1215914000638	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1215914000639	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1215914000640	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1215914000641	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1215914000642	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1215914000643	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1215914000644	TM-ABC transporter signature motif; other site
1215914000645	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1215914000646	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1215914000647	TM-ABC transporter signature motif; other site
1215914000648	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1215914000649	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1215914000650	Walker A/P-loop; other site
1215914000651	ATP binding site [chemical binding]; other site
1215914000652	Q-loop/lid; other site
1215914000653	ABC transporter signature motif; other site
1215914000654	Walker B; other site
1215914000655	D-loop; other site
1215914000656	H-loop/switch region; other site
1215914000657	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1215914000658	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1215914000659	Walker A/P-loop; other site
1215914000660	ATP binding site [chemical binding]; other site
1215914000661	Q-loop/lid; other site
1215914000662	ABC transporter signature motif; other site
1215914000663	Walker B; other site
1215914000664	D-loop; other site
1215914000665	H-loop/switch region; other site
1215914000666	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
1215914000667	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1215914000668	Class I aldolases; Region: Aldolase_Class_I; cl17187
1215914000669	catalytic residue [active]
1215914000670	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1215914000671	intersubunit interface [polypeptide binding]; other site
1215914000672	active site
1215914000673	catalytic residue [active]
1215914000674	phosphopentomutase; Provisional; Region: PRK05362
1215914000675	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1215914000676	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1215914000677	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1215914000678	NlpC/P60 family; Region: NLPC_P60; pfam00877
1215914000679	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
1215914000680	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1215914000681	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
1215914000682	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1215914000683	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1215914000684	DEAD_2; Region: DEAD_2; pfam06733
1215914000685	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1215914000686	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1215914000687	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1215914000688	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
1215914000689	active site
1215914000690	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1215914000691	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
1215914000692	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1215914000693	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1215914000694	DNA-binding site [nucleotide binding]; DNA binding site
1215914000695	UTRA domain; Region: UTRA; pfam07702
1215914000696	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
1215914000697	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1215914000698	dimer interface [polypeptide binding]; other site
1215914000699	active site
1215914000700	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
1215914000701	putative active site [active]
1215914000702	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1215914000703	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1215914000704	active site
1215914000705	dimer interface [polypeptide binding]; other site
1215914000706	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
1215914000707	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1215914000708	active site
1215914000709	phosphorylation site [posttranslational modification]
1215914000710	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
1215914000711	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
1215914000712	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1215914000713	active pocket/dimerization site; other site
1215914000714	active site
1215914000715	phosphorylation site [posttranslational modification]
1215914000716	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
1215914000717	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1215914000718	Transposase domain (DUF772); Region: DUF772; pfam05598
1215914000719	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1215914000720	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1215914000721	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1215914000722	homodimer interface [polypeptide binding]; other site
1215914000723	catalytic residue [active]
1215914000724	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1215914000725	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1215914000726	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1215914000727	active site
1215914000728	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1215914000729	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1215914000730	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1215914000731	active site
1215914000732	P-loop; other site
1215914000733	phosphorylation site [posttranslational modification]
1215914000734	PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255
1215914000735	active site
1215914000736	methionine cluster; other site
1215914000737	phosphorylation site [posttranslational modification]
1215914000738	metal binding site [ion binding]; metal-binding site
1215914000739	exoaminopeptidase; Provisional; Region: PRK09961
1215914000740	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1215914000741	oligomer interface [polypeptide binding]; other site
1215914000742	active site
1215914000743	metal binding site [ion binding]; metal-binding site
1215914000744	HTH domain; Region: HTH_11; pfam08279
1215914000745	PRD domain; Region: PRD; pfam00874
1215914000746	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1215914000747	active site
1215914000748	P-loop; other site
1215914000749	phosphorylation site [posttranslational modification]
1215914000750	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1215914000751	active site
1215914000752	phosphorylation site [posttranslational modification]
1215914000753	peptidase T; Region: peptidase-T; TIGR01882
1215914000754	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1215914000755	metal binding site [ion binding]; metal-binding site
1215914000756	dimer interface [polypeptide binding]; other site
1215914000757	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1215914000758	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1215914000759	peptide binding site [polypeptide binding]; other site
1215914000760	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1215914000761	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1215914000762	Coenzyme A binding pocket [chemical binding]; other site
1215914000763	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943
1215914000764	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1215914000765	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1215914000766	Walker A/P-loop; other site
1215914000767	ATP binding site [chemical binding]; other site
1215914000768	Q-loop/lid; other site
1215914000769	ABC transporter signature motif; other site
1215914000770	Walker B; other site
1215914000771	D-loop; other site
1215914000772	H-loop/switch region; other site
1215914000773	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1215914000774	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914000775	Walker A/P-loop; other site
1215914000776	ATP binding site [chemical binding]; other site
1215914000777	Q-loop/lid; other site
1215914000778	ABC transporter signature motif; other site
1215914000779	Walker B; other site
1215914000780	D-loop; other site
1215914000781	H-loop/switch region; other site
1215914000782	Cobalt transport protein; Region: CbiQ; cl00463
1215914000783	Putative transcription activator [Transcription]; Region: TenA; COG0819
1215914000784	Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952
1215914000785	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1215914000786	substrate binding site [chemical binding]; other site
1215914000787	multimerization interface [polypeptide binding]; other site
1215914000788	ATP binding site [chemical binding]; other site
1215914000789	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1215914000790	thiamine phosphate binding site [chemical binding]; other site
1215914000791	active site
1215914000792	pyrophosphate binding site [ion binding]; other site
1215914000793	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1215914000794	dimer interface [polypeptide binding]; other site
1215914000795	substrate binding site [chemical binding]; other site
1215914000796	ATP binding site [chemical binding]; other site
1215914000797	Amino acid permease; Region: AA_permease_2; pfam13520
1215914000798	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1215914000799	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1215914000800	DNA binding site [nucleotide binding]
1215914000801	domain linker motif; other site
1215914000802	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1215914000803	ligand binding site [chemical binding]; other site
1215914000804	dimerization interface [polypeptide binding]; other site
1215914000805	D-ribose pyranase; Provisional; Region: PRK11797
1215914000806	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1215914000807	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1215914000808	Walker A/P-loop; other site
1215914000809	ATP binding site [chemical binding]; other site
1215914000810	Q-loop/lid; other site
1215914000811	ABC transporter signature motif; other site
1215914000812	Walker B; other site
1215914000813	D-loop; other site
1215914000814	H-loop/switch region; other site
1215914000815	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1215914000816	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1215914000817	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1215914000818	TM-ABC transporter signature motif; other site
1215914000819	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
1215914000820	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1215914000821	ligand binding site [chemical binding]; other site
1215914000822	dimerization interface [polypeptide binding]; other site
1215914000823	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1215914000824	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1215914000825	substrate binding site [chemical binding]; other site
1215914000826	dimer interface [polypeptide binding]; other site
1215914000827	ATP binding site [chemical binding]; other site
1215914000828	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
1215914000829	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
1215914000830	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1215914000831	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1215914000832	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1215914000833	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914000834	putative substrate translocation pore; other site
1215914000835	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914000836	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1215914000837	MarR family; Region: MarR_2; pfam12802
1215914000838	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
1215914000839	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914000840	ABC transporter signature motif; other site
1215914000841	Walker B; other site
1215914000842	D-loop; other site
1215914000843	H-loop/switch region; other site
1215914000844	Transposase domain (DUF772); Region: DUF772; pfam05598
1215914000845	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1215914000846	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914000847	Walker A/P-loop; other site
1215914000848	ATP binding site [chemical binding]; other site
1215914000849	Q-loop/lid; other site
1215914000850	fumarate reductase flavoprotein subunit; Validated; Region: PRK06481
1215914000851	L-aspartate oxidase; Provisional; Region: PRK06175
1215914000852	Predicted oxidoreductase [General function prediction only]; Region: COG3573
1215914000853	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1215914000854	Mga helix-turn-helix domain; Region: Mga; pfam05043
1215914000855	PRD domain; Region: PRD; pfam00874
1215914000856	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1215914000857	active site
1215914000858	P-loop; other site
1215914000859	phosphorylation site [posttranslational modification]
1215914000860	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1215914000861	active site
1215914000862	phosphorylation site [posttranslational modification]
1215914000863	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1215914000864	active site
1215914000865	P-loop; other site
1215914000866	phosphorylation site [posttranslational modification]
1215914000867	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
1215914000868	Fructose-bisphosphate aldolase class-II; Region: F_bP_aldolase; pfam01116
1215914000869	active site
1215914000870	intersubunit interface [polypeptide binding]; other site
1215914000871	zinc binding site [ion binding]; other site
1215914000872	Na+ binding site [ion binding]; other site
1215914000873	AAA domain; Region: AAA_17; cl17253
1215914000874	AAA domain; Region: AAA_18; pfam13238
1215914000875	Predicted transcriptional regulators [Transcription]; Region: COG1378
1215914000876	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
1215914000877	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
1215914000878	C-terminal domain interface [polypeptide binding]; other site
1215914000879	sugar binding site [chemical binding]; other site
1215914000880	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1215914000881	ornithine cyclodeaminase; Validated; Region: PRK08618
1215914000882	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1215914000883	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1215914000884	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1215914000885	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1215914000886	Helix-turn-helix domain; Region: HTH_38; pfam13936
1215914000887	Integrase core domain; Region: rve; pfam00665
1215914000888	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1215914000889	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1215914000890	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1215914000891	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1215914000892	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1215914000893	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1215914000894	conserved hypothetical protein; Region: TIGR02328
1215914000895	Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013
1215914000896	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1215914000897	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1215914000898	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1215914000899	DNA binding site [nucleotide binding]
1215914000900	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1215914000901	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
1215914000902	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
1215914000903	Sulfatase; Region: Sulfatase; cl17466
1215914000904	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1215914000905	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1215914000906	Helix-turn-helix domain; Region: HTH_38; pfam13936
1215914000907	Integrase core domain; Region: rve; pfam00665
1215914000908	Sulfatase; Region: Sulfatase; cl17466
1215914000909	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1215914000910	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1215914000911	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1215914000912	anaerobic sulfatase-maturase; Provisional; Region: PRK13758
1215914000913	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1215914000914	FeS/SAM binding site; other site
1215914000915	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1215914000916	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1215914000917	active site
1215914000918	tetramer interface [polypeptide binding]; other site
1215914000919	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
1215914000920	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069
1215914000921	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1215914000922	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1215914000923	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1215914000924	DNA-binding site [nucleotide binding]; DNA binding site
1215914000925	Predicted esterase [General function prediction only]; Region: COG0627
1215914000926	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
1215914000927	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
1215914000928	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
1215914000929	active site
1215914000930	phosphorylation site [posttranslational modification]
1215914000931	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1215914000932	active pocket/dimerization site; other site
1215914000933	active site
1215914000934	phosphorylation site [posttranslational modification]
1215914000935	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
1215914000936	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1215914000937	Walker A motif; other site
1215914000938	ATP binding site [chemical binding]; other site
1215914000939	Walker B motif; other site
1215914000940	arginine finger; other site
1215914000941	Transcriptional antiterminator [Transcription]; Region: COG3933
1215914000942	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1215914000943	active pocket/dimerization site; other site
1215914000944	active site
1215914000945	phosphorylation site [posttranslational modification]
1215914000946	PRD domain; Region: PRD; pfam00874
1215914000947	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
1215914000948	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
1215914000949	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1215914000950	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1215914000951	HTH domain; Region: HTH_11; pfam08279
1215914000952	Mga helix-turn-helix domain; Region: Mga; pfam05043
1215914000953	PRD domain; Region: PRD; pfam00874
1215914000954	PRD domain; Region: PRD; pfam00874
1215914000955	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1215914000956	active site
1215914000957	P-loop; other site
1215914000958	phosphorylation site [posttranslational modification]
1215914000959	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
1215914000960	active site
1215914000961	phosphorylation site [posttranslational modification]
1215914000962	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1215914000963	intersubunit interface [polypeptide binding]; other site
1215914000964	active site
1215914000965	zinc binding site [ion binding]; other site
1215914000966	Na+ binding site [ion binding]; other site
1215914000967	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1215914000968	active site
1215914000969	phosphorylation site [posttranslational modification]
1215914000970	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1215914000971	active site
1215914000972	P-loop; other site
1215914000973	phosphorylation site [posttranslational modification]
1215914000974	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1215914000975	Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
1215914000976	active site
1215914000977	catalytic residues [active]
1215914000978	Protein of unknown function (DUF1498); Region: DUF1498; cl17840
1215914000979	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
1215914000980	N- and C-terminal domain interface [polypeptide binding]; other site
1215914000981	D-xylulose kinase; Region: XylB; TIGR01312
1215914000982	active site
1215914000983	MgATP binding site [chemical binding]; other site
1215914000984	catalytic site [active]
1215914000985	metal binding site [ion binding]; metal-binding site
1215914000986	xylulose binding site [chemical binding]; other site
1215914000987	homodimer interface [polypeptide binding]; other site
1215914000988	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1215914000989	Helix-turn-helix domain; Region: HTH_38; pfam13936
1215914000990	Integrase core domain; Region: rve; pfam00665
1215914000991	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1215914000992	active site
1215914000993	phosphorylation site [posttranslational modification]
1215914000994	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
1215914000995	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1215914000996	active site
1215914000997	P-loop; other site
1215914000998	phosphorylation site [posttranslational modification]
1215914000999	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1215914001000	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1215914001001	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1215914001002	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1215914001003	homodimer interface [polypeptide binding]; other site
1215914001004	catalytic residue [active]
1215914001005	putative frv operon regulatory protein; Provisional; Region: PRK09863
1215914001006	HTH domain; Region: HTH_11; pfam08279
1215914001007	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
1215914001008	active site
1215914001009	phosphorylation site [posttranslational modification]
1215914001010	HTH domain; Region: HTH_11; pfam08279
1215914001011	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1215914001012	PRD domain; Region: PRD; pfam00874
1215914001013	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
1215914001014	active site
1215914001015	phosphorylation site [posttranslational modification]
1215914001016	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1215914001017	intersubunit interface [polypeptide binding]; other site
1215914001018	active site
1215914001019	zinc binding site [ion binding]; other site
1215914001020	Na+ binding site [ion binding]; other site
1215914001021	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
1215914001022	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1215914001023	active site
1215914001024	phosphorylation site [posttranslational modification]
1215914001025	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1215914001026	active site
1215914001027	P-loop; other site
1215914001028	phosphorylation site [posttranslational modification]
1215914001029	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1215914001030	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1215914001031	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1215914001032	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1215914001033	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1215914001034	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1215914001035	sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171
1215914001036	classical (c) SDRs; Region: SDR_c; cd05233
1215914001037	NAD(P) binding site [chemical binding]; other site
1215914001038	active site
1215914001039	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1215914001040	active pocket/dimerization site; other site
1215914001041	active site
1215914001042	phosphorylation site [posttranslational modification]
1215914001043	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
1215914001044	active site
1215914001045	phosphorylation site [posttranslational modification]
1215914001046	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
1215914001047	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
1215914001048	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
1215914001049	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1215914001050	DAK2 domain; Region: Dak2; pfam02734
1215914001051	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1215914001052	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
1215914001053	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
1215914001054	active site
1215914001055	dimer interface [polypeptide binding]; other site
1215914001056	magnesium binding site [ion binding]; other site
1215914001057	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1215914001058	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
1215914001059	tetramer interface [polypeptide binding]; other site
1215914001060	active site
1215914001061	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1215914001062	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1215914001063	DNA-binding site [nucleotide binding]; DNA binding site
1215914001064	UTRA domain; Region: UTRA; pfam07702
1215914001065	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
1215914001066	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1215914001067	putative NAD(P) binding site [chemical binding]; other site
1215914001068	catalytic Zn binding site [ion binding]; other site
1215914001069	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1215914001070	DNA binding residues [nucleotide binding]
1215914001071	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1215914001072	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1215914001073	sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171
1215914001074	classical (c) SDRs; Region: SDR_c; cd05233
1215914001075	NAD(P) binding site [chemical binding]; other site
1215914001076	active site
1215914001077	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1215914001078	active pocket/dimerization site; other site
1215914001079	active site
1215914001080	phosphorylation site [posttranslational modification]
1215914001081	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1215914001082	active site
1215914001083	phosphorylation site [posttranslational modification]
1215914001084	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
1215914001085	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
1215914001086	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1215914001087	intersubunit interface [polypeptide binding]; other site
1215914001088	active site
1215914001089	zinc binding site [ion binding]; other site
1215914001090	Na+ binding site [ion binding]; other site
1215914001091	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1215914001092	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1215914001093	transmembrane helices; other site
1215914001094	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
1215914001095	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1215914001096	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1215914001097	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1215914001098	dimerization interface [polypeptide binding]; other site
1215914001099	Uncharacterized conserved protein [Function unknown]; Region: COG1912
1215914001100	hypothetical protein; Provisional; Region: PRK13661
1215914001101	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1215914001102	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1215914001103	Walker A/P-loop; other site
1215914001104	ATP binding site [chemical binding]; other site
1215914001105	Q-loop/lid; other site
1215914001106	ABC transporter signature motif; other site
1215914001107	Walker B; other site
1215914001108	D-loop; other site
1215914001109	H-loop/switch region; other site
1215914001110	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
1215914001111	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1215914001112	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1215914001113	Walker A/P-loop; other site
1215914001114	ATP binding site [chemical binding]; other site
1215914001115	Q-loop/lid; other site
1215914001116	ABC transporter signature motif; other site
1215914001117	Walker B; other site
1215914001118	D-loop; other site
1215914001119	H-loop/switch region; other site
1215914001120	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1215914001121	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1215914001122	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1215914001123	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
1215914001124	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1215914001125	Transcriptional antiterminator [Transcription]; Region: COG3933
1215914001126	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1215914001127	active pocket/dimerization site; other site
1215914001128	active site
1215914001129	phosphorylation site [posttranslational modification]
1215914001130	PRD domain; Region: PRD; pfam00874
1215914001131	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1215914001132	active pocket/dimerization site; other site
1215914001133	active site
1215914001134	phosphorylation site [posttranslational modification]
1215914001135	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
1215914001136	active site
1215914001137	phosphorylation site [posttranslational modification]
1215914001138	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
1215914001139	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
1215914001140	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1215914001141	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1215914001142	motif II; other site
1215914001143	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1215914001144	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1215914001145	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1215914001146	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
1215914001147	active site
1215914001148	dimer interface [polypeptide binding]; other site
1215914001149	magnesium binding site [ion binding]; other site
1215914001150	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
1215914001151	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
1215914001152	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
1215914001153	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1215914001154	active site
1215914001155	P-loop; other site
1215914001156	phosphorylation site [posttranslational modification]
1215914001157	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1215914001158	active site
1215914001159	phosphorylation site [posttranslational modification]
1215914001160	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1215914001161	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
1215914001162	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1215914001163	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1215914001164	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
1215914001165	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1215914001166	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1215914001167	substrate binding pocket [chemical binding]; other site
1215914001168	membrane-bound complex binding site; other site
1215914001169	hinge residues; other site
1215914001170	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914001171	dimer interface [polypeptide binding]; other site
1215914001172	conserved gate region; other site
1215914001173	putative PBP binding loops; other site
1215914001174	ABC-ATPase subunit interface; other site
1215914001175	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
1215914001176	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914001177	putative substrate translocation pore; other site
1215914001178	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1215914001179	YvrJ protein family; Region: YvrJ; pfam12841
1215914001180	AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522
1215914001181	active site
1215914001182	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1215914001183	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1215914001184	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1215914001185	classical (c) SDRs; Region: SDR_c; cd05233
1215914001186	NAD(P) binding site [chemical binding]; other site
1215914001187	active site
1215914001188	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1215914001189	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1215914001190	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1215914001191	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1215914001192	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1215914001193	FtsX-like permease family; Region: FtsX; pfam02687
1215914001194	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1215914001195	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1215914001196	Walker A/P-loop; other site
1215914001197	ATP binding site [chemical binding]; other site
1215914001198	Q-loop/lid; other site
1215914001199	ABC transporter signature motif; other site
1215914001200	Walker B; other site
1215914001201	D-loop; other site
1215914001202	H-loop/switch region; other site
1215914001203	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914001204	non-specific DNA binding site [nucleotide binding]; other site
1215914001205	salt bridge; other site
1215914001206	sequence-specific DNA binding site [nucleotide binding]; other site
1215914001207	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
1215914001208	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
1215914001209	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1215914001210	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1215914001211	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1215914001212	active site
1215914001213	motif I; other site
1215914001214	motif II; other site
1215914001215	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
1215914001216	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1215914001217	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
1215914001218	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1215914001219	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1215914001220	DNA binding site [nucleotide binding]
1215914001221	domain linker motif; other site
1215914001222	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
1215914001223	putative dimerization interface [polypeptide binding]; other site
1215914001224	putative ligand binding site [chemical binding]; other site
1215914001225	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
1215914001226	active site
1215914001227	phosphorylation site [posttranslational modification]
1215914001228	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
1215914001229	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
1215914001230	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
1215914001231	This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595
1215914001232	putative active site [active]
1215914001233	putative catalytic site [active]
1215914001234	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1215914001235	active pocket/dimerization site; other site
1215914001236	active site
1215914001237	phosphorylation site [posttranslational modification]
1215914001238	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1215914001239	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1215914001240	Ca binding site [ion binding]; other site
1215914001241	active site
1215914001242	catalytic site [active]
1215914001243	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1215914001244	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1215914001245	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1215914001246	Walker A/P-loop; other site
1215914001247	ATP binding site [chemical binding]; other site
1215914001248	Q-loop/lid; other site
1215914001249	ABC transporter signature motif; other site
1215914001250	Walker B; other site
1215914001251	D-loop; other site
1215914001252	H-loop/switch region; other site
1215914001253	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1215914001254	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1215914001255	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1215914001256	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1215914001257	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914001258	Walker A/P-loop; other site
1215914001259	ATP binding site [chemical binding]; other site
1215914001260	Q-loop/lid; other site
1215914001261	ABC transporter signature motif; other site
1215914001262	Walker B; other site
1215914001263	D-loop; other site
1215914001264	H-loop/switch region; other site
1215914001265	Predicted membrane protein [Function unknown]; Region: COG1511
1215914001266	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1215914001267	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1215914001268	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1215914001269	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1215914001270	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1215914001271	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1215914001272	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
1215914001273	active site
1215914001274	myosin-cross-reactive antigen; Provisional; Region: PRK13977
1215914001275	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1215914001276	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1215914001277	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
1215914001278	DAK2 domain; Region: Dak2; cl03685
1215914001279	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
1215914001280	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1215914001281	OsmC-like protein; Region: OsmC; cl00767
1215914001282	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1215914001283	active site
1215914001284	catalytic site [active]
1215914001285	substrate binding site [chemical binding]; other site
1215914001286	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1215914001287	dimerization interface [polypeptide binding]; other site
1215914001288	putative DNA binding site [nucleotide binding]; other site
1215914001289	putative Zn2+ binding site [ion binding]; other site
1215914001290	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914001291	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1215914001292	putative substrate translocation pore; other site
1215914001293	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1215914001294	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1215914001295	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1215914001296	intersubunit interface [polypeptide binding]; other site
1215914001297	active site
1215914001298	zinc binding site [ion binding]; other site
1215914001299	Na+ binding site [ion binding]; other site
1215914001300	pyruvate oxidase; Provisional; Region: PRK08611
1215914001301	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1215914001302	PYR/PP interface [polypeptide binding]; other site
1215914001303	dimer interface [polypeptide binding]; other site
1215914001304	tetramer interface [polypeptide binding]; other site
1215914001305	TPP binding site [chemical binding]; other site
1215914001306	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1215914001307	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1215914001308	TPP-binding site [chemical binding]; other site
1215914001309	Beta-lactamase; Region: Beta-lactamase; pfam00144
1215914001310	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1215914001311	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1215914001312	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1215914001313	S-adenosylmethionine binding site [chemical binding]; other site
1215914001314	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1215914001315	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1215914001316	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1215914001317	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1215914001318	Amino acid permease; Region: AA_permease_2; pfam13520
1215914001319	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1215914001320	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1215914001321	DNA binding residues [nucleotide binding]
1215914001322	putative dimer interface [polypeptide binding]; other site
1215914001323	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1215914001324	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1215914001325	active site
1215914001326	catalytic tetrad [active]
1215914001327	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1215914001328	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1215914001329	putative NAD(P) binding site [chemical binding]; other site
1215914001330	dimer interface [polypeptide binding]; other site
1215914001331	Predicted transcriptional regulators [Transcription]; Region: COG1733
1215914001332	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1215914001333	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1215914001334	beta-galactosidase; Region: BGL; TIGR03356
1215914001335	PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255
1215914001336	active site
1215914001337	methionine cluster; other site
1215914001338	phosphorylation site [posttranslational modification]
1215914001339	metal binding site [ion binding]; metal-binding site
1215914001340	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1215914001341	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1215914001342	active site
1215914001343	P-loop; other site
1215914001344	phosphorylation site [posttranslational modification]
1215914001345	HTH domain; Region: HTH_11; cl17392
1215914001346	Mga helix-turn-helix domain; Region: Mga; pfam05043
1215914001347	PRD domain; Region: PRD; pfam00874
1215914001348	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1215914001349	active site
1215914001350	phosphorylation site [posttranslational modification]
1215914001351	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1215914001352	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1215914001353	catalytic residues [active]
1215914001354	catalytic nucleophile [active]
1215914001355	Presynaptic Site I dimer interface [polypeptide binding]; other site
1215914001356	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1215914001357	Synaptic Flat tetramer interface [polypeptide binding]; other site
1215914001358	Synaptic Site I dimer interface [polypeptide binding]; other site
1215914001359	DNA binding site [nucleotide binding]
1215914001360	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1215914001361	metal ion-dependent adhesion site (MIDAS); other site
1215914001362	Cna protein B-type domain; Region: Cna_B; pfam05738
1215914001363	Cna protein B-type domain; Region: Cna_B; pfam05738
1215914001364	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1215914001365	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1215914001366	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
1215914001367	active site
1215914001368	catalytic site [active]
1215914001369	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1215914001370	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
1215914001371	Walker A/P-loop; other site
1215914001372	ATP binding site [chemical binding]; other site
1215914001373	Q-loop/lid; other site
1215914001374	ABC transporter signature motif; other site
1215914001375	Walker B; other site
1215914001376	D-loop; other site
1215914001377	H-loop/switch region; other site
1215914001378	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1215914001379	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1215914001380	active site
1215914001381	phosphorylation site [posttranslational modification]
1215914001382	intermolecular recognition site; other site
1215914001383	dimerization interface [polypeptide binding]; other site
1215914001384	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1215914001385	DNA binding site [nucleotide binding]
1215914001386	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1215914001387	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1215914001388	dimerization interface [polypeptide binding]; other site
1215914001389	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1215914001390	dimer interface [polypeptide binding]; other site
1215914001391	phosphorylation site [posttranslational modification]
1215914001392	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1215914001393	ATP binding site [chemical binding]; other site
1215914001394	Mg2+ binding site [ion binding]; other site
1215914001395	G-X-G motif; other site
1215914001396	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
1215914001397	Walker A/P-loop; other site
1215914001398	ATP binding site [chemical binding]; other site
1215914001399	ABC transporter; Region: ABC_tran; pfam00005
1215914001400	Q-loop/lid; other site
1215914001401	ABC transporter signature motif; other site
1215914001402	Walker B; other site
1215914001403	D-loop; other site
1215914001404	H-loop/switch region; other site
1215914001405	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1215914001406	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
1215914001407	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
1215914001408	catalytic triad [active]
1215914001409	putative active site [active]
1215914001410	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
1215914001411	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
1215914001412	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
1215914001413	catalytic triad [active]
1215914001414	putative active site [active]
1215914001415	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
1215914001416	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
1215914001417	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
1215914001418	Zn binding site [ion binding]; other site
1215914001419	inner membrane transporter YjeM; Provisional; Region: PRK15238
1215914001420	Protein of unknown function (DUF1440); Region: DUF1440; pfam07274
1215914001421	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1215914001422	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1215914001423	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
1215914001424	putative dimerization interface [polypeptide binding]; other site
1215914001425	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1215914001426	classical (c) SDRs; Region: SDR_c; cd05233
1215914001427	NAD(P) binding site [chemical binding]; other site
1215914001428	active site
1215914001429	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1215914001430	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1215914001431	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1215914001432	shikimate binding site; other site
1215914001433	NAD(P) binding site [chemical binding]; other site
1215914001434	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914001435	putative substrate translocation pore; other site
1215914001436	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1215914001437	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
1215914001438	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1215914001439	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1215914001440	shikimate binding site; other site
1215914001441	NAD(P) binding site [chemical binding]; other site
1215914001442	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
1215914001443	proposed active site lysine [active]
1215914001444	conserved cys residue [active]
1215914001445	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1215914001446	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1215914001447	dimer interface [polypeptide binding]; other site
1215914001448	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1215914001449	catalytic residue [active]
1215914001450	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1215914001451	Int/Topo IB signature motif; other site
1215914001452	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1215914001453	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1215914001454	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914001455	non-specific DNA binding site [nucleotide binding]; other site
1215914001456	salt bridge; other site
1215914001457	sequence-specific DNA binding site [nucleotide binding]; other site
1215914001458	Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509
1215914001459	ORF6N domain; Region: ORF6N; pfam10543
1215914001460	ORF6C domain; Region: ORF6C; pfam10552
1215914001461	Domain of unknown function (DUF1883); Region: DUF1883; pfam08980
1215914001462	Domain of unknown function (DUF771); Region: DUF771; pfam05595
1215914001463	DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061
1215914001464	Helix-turn-helix domain; Region: HTH_36; pfam13730
1215914001465	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
1215914001466	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
1215914001467	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
1215914001468	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1215914001469	Walker A motif; other site
1215914001470	ATP binding site [chemical binding]; other site
1215914001471	Walker B motif; other site
1215914001472	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
1215914001473	active site
1215914001474	catalytic site [active]
1215914001475	substrate binding site [chemical binding]; other site
1215914001476	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
1215914001477	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1215914001478	active site
1215914001479	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1215914001480	Helix-turn-helix domain; Region: HTH_38; pfam13936
1215914001481	Integrase core domain; Region: rve; pfam00665
1215914001482	GcrA cell cycle regulator; Region: GcrA; cl11564
1215914001483	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1215914001484	Transposase; Region: HTH_Tnp_1; pfam01527
1215914001485	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1215914001486	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1215914001487	Homeodomain-like domain; Region: HTH_23; cl17451
1215914001488	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1215914001489	Transposase; Region: HTH_Tnp_1; cl17663
1215914001490	Helix-turn-helix domain; Region: HTH_28; pfam13518
1215914001491	putative transposase OrfB; Reviewed; Region: PHA02517
1215914001492	HTH-like domain; Region: HTH_21; pfam13276
1215914001493	Integrase core domain; Region: rve; pfam00665
1215914001494	Integrase core domain; Region: rve_3; pfam13683
1215914001495	HTH-like domain; Region: HTH_21; pfam13276
1215914001496	Integrase core domain; Region: rve; pfam00665
1215914001497	Integrase core domain; Region: rve_3; cl15866
1215914001498	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1215914001499	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
1215914001500	generic binding surface II; other site
1215914001501	generic binding surface I; other site
1215914001502	AAA-like domain; Region: AAA_10; pfam12846
1215914001503	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1215914001504	Walker A motif; other site
1215914001505	ATP binding site [chemical binding]; other site
1215914001506	Walker B motif; other site
1215914001507	hypothetical protein; Provisional; Region: PRK12495
1215914001508	AAA-like domain; Region: AAA_10; pfam12846
1215914001509	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
1215914001510	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1215914001511	NlpC/P60 family; Region: NLPC_P60; cl17555
1215914001512	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1215914001513	catalytic residues [active]
1215914001514	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
1215914001515	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1215914001516	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
1215914001517	Toprim-like; Region: Toprim_2; pfam13155
1215914001518	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
1215914001519	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1215914001520	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
1215914001521	active site
1215914001522	catalytic site [active]
1215914001523	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
1215914001524	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1215914001525	Cl- selectivity filter; other site
1215914001526	Cl- binding residues [ion binding]; other site
1215914001527	pore gating glutamate residue; other site
1215914001528	dimer interface [polypeptide binding]; other site
1215914001529	H+/Cl- coupling transport residue; other site
1215914001530	TrkA-C domain; Region: TrkA_C; pfam02080
1215914001531	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1215914001532	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1215914001533	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1215914001534	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1215914001535	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1215914001536	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1215914001537	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1215914001538	active site
1215914001539	motif I; other site
1215914001540	motif II; other site
1215914001541	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1215914001542	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1215914001543	Integrase core domain; Region: rve; pfam00665
1215914001544	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1215914001545	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
1215914001546	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1215914001547	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1215914001548	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1215914001549	Integrase core domain; Region: rve; pfam00665
1215914001550	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1215914001551	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1215914001552	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
1215914001553	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
1215914001554	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021
1215914001555	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021
1215914001556	active site
1215914001557	phosphorylation site [posttranslational modification]
1215914001558	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1215914001559	active pocket/dimerization site; other site
1215914001560	active site
1215914001561	phosphorylation site [posttranslational modification]
1215914001562	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1215914001563	intersubunit interface [polypeptide binding]; other site
1215914001564	active site
1215914001565	catalytic residue [active]
1215914001566	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1215914001567	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1215914001568	DNA-binding site [nucleotide binding]; DNA binding site
1215914001569	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1215914001570	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1215914001571	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1215914001572	catalytic residues [active]
1215914001573	catalytic nucleophile [active]
1215914001574	Presynaptic Site I dimer interface [polypeptide binding]; other site
1215914001575	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1215914001576	Synaptic Flat tetramer interface [polypeptide binding]; other site
1215914001577	Synaptic Site I dimer interface [polypeptide binding]; other site
1215914001578	DNA binding site [nucleotide binding]
1215914001579	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
1215914001580	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
1215914001581	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1215914001582	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1215914001583	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
1215914001584	putative transposase OrfB; Reviewed; Region: PHA02517
1215914001585	HTH-like domain; Region: HTH_21; pfam13276
1215914001586	Integrase core domain; Region: rve; pfam00665
1215914001587	Integrase core domain; Region: rve_3; pfam13683
1215914001588	Helix-turn-helix domain; Region: HTH_28; pfam13518
1215914001589	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
1215914001590	ApbE family; Region: ApbE; pfam02424
1215914001591	Predicted flavoprotein [General function prediction only]; Region: COG0431
1215914001592	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1215914001593	Predicted flavoprotein [General function prediction only]; Region: COG0431
1215914001594	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1215914001595	PAS domain; Region: PAS_10; pfam13596
1215914001596	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1215914001597	Transposase; Region: HTH_Tnp_1; pfam01527
1215914001598	HTH-like domain; Region: HTH_21; pfam13276
1215914001599	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1215914001600	Integrase core domain; Region: rve; pfam00665
1215914001601	Integrase core domain; Region: rve_3; pfam13683
1215914001602	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
1215914001603	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1215914001604	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1215914001605	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1215914001606	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1215914001607	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1215914001608	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1215914001609	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1215914001610	transmembrane helices; other site
1215914001611	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
1215914001612	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1215914001613	Transposase; Region: HTH_Tnp_1; cl17663
1215914001614	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
1215914001615	active site
1215914001616	Bacterial SH3 domain; Region: SH3_5; pfam08460
1215914001617	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1215914001618	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1215914001619	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
1215914001620	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1215914001621	homodimer interface [polypeptide binding]; other site
1215914001622	substrate-cofactor binding pocket; other site
1215914001623	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1215914001624	catalytic residue [active]
1215914001625	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1215914001626	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1215914001627	substrate binding pocket [chemical binding]; other site
1215914001628	membrane-bound complex binding site; other site
1215914001629	hinge residues; other site
1215914001630	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914001631	dimer interface [polypeptide binding]; other site
1215914001632	conserved gate region; other site
1215914001633	putative PBP binding loops; other site
1215914001634	ABC-ATPase subunit interface; other site
1215914001635	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
1215914001636	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1215914001637	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
1215914001638	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
1215914001639	legume lectins; Region: lectin_L-type; cd01951
1215914001640	homotetramer interaction site [polypeptide binding]; other site
1215914001641	homodimer interaction site [polypeptide binding]; other site
1215914001642	carbohydrate binding site [chemical binding]; other site
1215914001643	metal binding site [ion binding]; metal-binding site
1215914001644	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1215914001645	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1215914001646	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1215914001647	legume lectins; Region: lectin_L-type; cd01951
1215914001648	homotetramer interaction site [polypeptide binding]; other site
1215914001649	carbohydrate binding site [chemical binding]; other site
1215914001650	metal binding site [ion binding]; metal-binding site
1215914001651	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1215914001652	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1215914001653	EamA-like transporter family; Region: EamA; pfam00892
1215914001654	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1215914001655	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1215914001656	Walker A/P-loop; other site
1215914001657	ATP binding site [chemical binding]; other site
1215914001658	Q-loop/lid; other site
1215914001659	ABC transporter signature motif; other site
1215914001660	Walker B; other site
1215914001661	D-loop; other site
1215914001662	H-loop/switch region; other site
1215914001663	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
1215914001664	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1215914001665	substrate binding site [chemical binding]; other site
1215914001666	ATP binding site [chemical binding]; other site
1215914001667	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
1215914001668	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1215914001669	THF binding site; other site
1215914001670	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1215914001671	substrate binding site [chemical binding]; other site
1215914001672	THF binding site; other site
1215914001673	zinc-binding site [ion binding]; other site
1215914001674	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1215914001675	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1215914001676	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914001677	Walker A/P-loop; other site
1215914001678	ATP binding site [chemical binding]; other site
1215914001679	Q-loop/lid; other site
1215914001680	ABC transporter signature motif; other site
1215914001681	Walker B; other site
1215914001682	D-loop; other site
1215914001683	H-loop/switch region; other site
1215914001684	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1215914001685	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1215914001686	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1215914001687	Walker A/P-loop; other site
1215914001688	ATP binding site [chemical binding]; other site
1215914001689	Q-loop/lid; other site
1215914001690	ABC transporter signature motif; other site
1215914001691	Walker B; other site
1215914001692	D-loop; other site
1215914001693	H-loop/switch region; other site
1215914001694	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
1215914001695	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914001696	putative substrate translocation pore; other site
1215914001697	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
1215914001698	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1215914001699	DNA-binding site [nucleotide binding]; DNA binding site
1215914001700	UTRA domain; Region: UTRA; pfam07702
1215914001701	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1215914001702	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1215914001703	Ca binding site [ion binding]; other site
1215914001704	active site
1215914001705	catalytic site [active]
1215914001706	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1215914001707	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1215914001708	HPr interaction site; other site
1215914001709	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1215914001710	active site
1215914001711	phosphorylation site [posttranslational modification]
1215914001712	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1215914001713	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1215914001714	active site turn [active]
1215914001715	phosphorylation site [posttranslational modification]
1215914001716	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1215914001717	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1215914001718	serine/threonine transporter SstT; Provisional; Region: PRK13628
1215914001719	amino acid transporter; Region: 2A0306; TIGR00909
1215914001720	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1215914001721	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1215914001722	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1215914001723	NAD binding site [chemical binding]; other site
1215914001724	dimer interface [polypeptide binding]; other site
1215914001725	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1215914001726	substrate binding site [chemical binding]; other site
1215914001727	glutamate dehydrogenase; Provisional; Region: PRK09414
1215914001728	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1215914001729	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1215914001730	NAD(P) binding site [chemical binding]; other site
1215914001731	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1215914001732	DNA-binding site [nucleotide binding]; DNA binding site
1215914001733	RNA-binding motif; other site
1215914001734	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
1215914001735	OsmC-like protein; Region: OsmC; pfam02566
1215914001736	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1215914001737	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1215914001738	ABC transporter; Region: ABC_tran_2; pfam12848
1215914001739	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1215914001740	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
1215914001741	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1215914001742	NAD(P) binding site [chemical binding]; other site
1215914001743	putative active site [active]
1215914001744	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1215914001745	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1215914001746	active site
1215914001747	catalytic tetrad [active]
1215914001748	putative transport protein YifK; Provisional; Region: PRK10746
1215914001749	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
1215914001750	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1215914001751	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
1215914001752	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1215914001753	LytTr DNA-binding domain; Region: LytTR; smart00850
1215914001754	Predicted membrane protein [Function unknown]; Region: COG1511
1215914001755	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1215914001756	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914001757	Walker A/P-loop; other site
1215914001758	ATP binding site [chemical binding]; other site
1215914001759	Q-loop/lid; other site
1215914001760	ABC transporter signature motif; other site
1215914001761	Walker B; other site
1215914001762	D-loop; other site
1215914001763	H-loop/switch region; other site
1215914001764	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
1215914001765	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
1215914001766	active site
1215914001767	zinc binding site [ion binding]; other site
1215914001768	hypothetical protein; Provisional; Region: PRK00967
1215914001769	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1215914001770	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1215914001771	putative NAD(P) binding site [chemical binding]; other site
1215914001772	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1215914001773	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
1215914001774	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1215914001775	MgtC family; Region: MgtC; pfam02308
1215914001776	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930
1215914001777	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1215914001778	Rhomboid family; Region: Rhomboid; cl11446
1215914001779	Rhomboid family; Region: Rhomboid; cl11446
1215914001780	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914001781	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1215914001782	Walker A/P-loop; other site
1215914001783	ATP binding site [chemical binding]; other site
1215914001784	Q-loop/lid; other site
1215914001785	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1215914001786	ABC transporter; Region: ABC_tran_2; pfam12848
1215914001787	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1215914001788	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914001789	Walker A/P-loop; other site
1215914001790	ATP binding site [chemical binding]; other site
1215914001791	Q-loop/lid; other site
1215914001792	ABC transporter signature motif; other site
1215914001793	Walker B; other site
1215914001794	D-loop; other site
1215914001795	H-loop/switch region; other site
1215914001796	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
1215914001797	putative uracil binding site [chemical binding]; other site
1215914001798	putative active site [active]
1215914001799	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
1215914001800	amphipathic channel; other site
1215914001801	Asn-Pro-Ala signature motifs; other site
1215914001802	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1215914001803	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1215914001804	glycerol kinase; Provisional; Region: glpK; PRK00047
1215914001805	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1215914001806	N- and C-terminal domain interface [polypeptide binding]; other site
1215914001807	active site
1215914001808	MgATP binding site [chemical binding]; other site
1215914001809	catalytic site [active]
1215914001810	metal binding site [ion binding]; metal-binding site
1215914001811	glycerol binding site [chemical binding]; other site
1215914001812	homotetramer interface [polypeptide binding]; other site
1215914001813	homodimer interface [polypeptide binding]; other site
1215914001814	FBP binding site [chemical binding]; other site
1215914001815	protein IIAGlc interface [polypeptide binding]; other site
1215914001816	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1215914001817	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1215914001818	active site
1215914001819	CAT RNA binding domain; Region: CAT_RBD; pfam03123
1215914001820	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1215914001821	PRD domain; Region: PRD; pfam00874
1215914001822	PRD domain; Region: PRD; pfam00874
1215914001823	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
1215914001824	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1215914001825	PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565
1215914001826	active site
1215914001827	P-loop; other site
1215914001828	phosphorylation site [posttranslational modification]
1215914001829	6-phospho-beta-galactosidase; Region: lacG; TIGR01233
1215914001830	beta-galactosidase; Region: BGL; TIGR03356
1215914001831	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1215914001832	methionine cluster; other site
1215914001833	active site
1215914001834	phosphorylation site [posttranslational modification]
1215914001835	metal binding site [ion binding]; metal-binding site
1215914001836	galactokinase; Provisional; Region: PRK05322
1215914001837	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1215914001838	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1215914001839	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1215914001840	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1215914001841	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1215914001842	NAD binding site [chemical binding]; other site
1215914001843	homodimer interface [polypeptide binding]; other site
1215914001844	active site
1215914001845	substrate binding site [chemical binding]; other site
1215914001846	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
1215914001847	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
1215914001848	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
1215914001849	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1215914001850	DNA binding site [nucleotide binding]
1215914001851	domain linker motif; other site
1215914001852	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
1215914001853	putative dimerization interface [polypeptide binding]; other site
1215914001854	putative ligand binding site [chemical binding]; other site
1215914001855	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1215914001856	active site
1215914001857	catalytic residues [active]
1215914001858	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1215914001859	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1215914001860	active site
1215914001861	phosphorylation site [posttranslational modification]
1215914001862	Phosphotransferase system, galactitol-specific IIB component [Carbohydrate transport and metabolism]; Region: SgaB; COG3414
1215914001863	active site
1215914001864	P-loop; other site
1215914001865	phosphorylation site [posttranslational modification]
1215914001866	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
1215914001867	PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611
1215914001868	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1215914001869	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
1215914001870	putative substrate binding site [chemical binding]; other site
1215914001871	putative ATP binding site [chemical binding]; other site
1215914001872	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
1215914001873	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
1215914001874	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
1215914001875	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1215914001876	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1215914001877	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1215914001878	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1215914001879	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1215914001880	motif II; other site
1215914001881	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1215914001882	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1215914001883	active site
1215914001884	metal binding site [ion binding]; metal-binding site
1215914001885	DNA binding site [nucleotide binding]
1215914001886	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1215914001887	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1215914001888	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1215914001889	Walker A/P-loop; other site
1215914001890	ATP binding site [chemical binding]; other site
1215914001891	Q-loop/lid; other site
1215914001892	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914001893	ABC transporter signature motif; other site
1215914001894	Walker B; other site
1215914001895	D-loop; other site
1215914001896	H-loop/switch region; other site
1215914001897	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1215914001898	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
1215914001899	putative dimer interface [polypeptide binding]; other site
1215914001900	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1215914001901	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1215914001902	minor groove reading motif; other site
1215914001903	helix-hairpin-helix signature motif; other site
1215914001904	substrate binding pocket [chemical binding]; other site
1215914001905	active site
1215914001906	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1215914001907	DNA binding and oxoG recognition site [nucleotide binding]
1215914001908	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1215914001909	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1215914001910	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
1215914001911	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
1215914001912	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1215914001913	dimer interface [polypeptide binding]; other site
1215914001914	substrate binding site [chemical binding]; other site
1215914001915	ATP binding site [chemical binding]; other site
1215914001916	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1215914001917	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1215914001918	NAD binding site [chemical binding]; other site
1215914001919	substrate binding site [chemical binding]; other site
1215914001920	putative active site [active]
1215914001921	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1215914001922	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1215914001923	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1215914001924	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1215914001925	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
1215914001926	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1215914001927	zinc binding site [ion binding]; other site
1215914001928	putative ligand binding site [chemical binding]; other site
1215914001929	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
1215914001930	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1215914001931	zinc binding site [ion binding]; other site
1215914001932	putative ligand binding site [chemical binding]; other site
1215914001933	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1215914001934	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
1215914001935	TM-ABC transporter signature motif; other site
1215914001936	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
1215914001937	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914001938	Walker A/P-loop; other site
1215914001939	ATP binding site [chemical binding]; other site
1215914001940	Q-loop/lid; other site
1215914001941	ABC transporter signature motif; other site
1215914001942	Walker B; other site
1215914001943	D-loop; other site
1215914001944	H-loop/switch region; other site
1215914001945	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
1215914001946	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1215914001947	NADP binding site [chemical binding]; other site
1215914001948	dimer interface [polypeptide binding]; other site
1215914001949	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1215914001950	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
1215914001951	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1215914001952	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1215914001953	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1215914001954	motif II; other site
1215914001955	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1215914001956	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1215914001957	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1215914001958	Ligand binding site; other site
1215914001959	Putative Catalytic site; other site
1215914001960	DXD motif; other site
1215914001961	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1215914001962	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1215914001963	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
1215914001964	Predicted membrane protein [Function unknown]; Region: COG2246
1215914001965	GtrA-like protein; Region: GtrA; pfam04138
1215914001966	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1215914001967	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1215914001968	active site
1215914001969	phosphorylation site [posttranslational modification]
1215914001970	intermolecular recognition site; other site
1215914001971	dimerization interface [polypeptide binding]; other site
1215914001972	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1215914001973	DNA binding site [nucleotide binding]
1215914001974	Di-sulfide bridge nucleocytoplasmic transport domain; Region: Brr6_like_C_C; cl12377
1215914001975	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1215914001976	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1215914001977	dimer interface [polypeptide binding]; other site
1215914001978	phosphorylation site [posttranslational modification]
1215914001979	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1215914001980	ATP binding site [chemical binding]; other site
1215914001981	Mg2+ binding site [ion binding]; other site
1215914001982	G-X-G motif; other site
1215914001983	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918
1215914001984	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1215914001985	hypothetical protein; Provisional; Region: PRK06194
1215914001986	classical (c) SDRs; Region: SDR_c; cd05233
1215914001987	NAD(P) binding site [chemical binding]; other site
1215914001988	active site
1215914001989	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
1215914001990	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1215914001991	dimer interface [polypeptide binding]; other site
1215914001992	FMN binding site [chemical binding]; other site
1215914001993	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1215914001994	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
1215914001995	phosphate binding site [ion binding]; other site
1215914001996	Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083
1215914001997	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1215914001998	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1215914001999	putative NAD(P) binding site [chemical binding]; other site
1215914002000	dimer interface [polypeptide binding]; other site
1215914002001	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1215914002002	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1215914002003	LexA repressor; Validated; Region: PRK00215
1215914002004	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1215914002005	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1215914002006	Catalytic site [active]
1215914002007	Membrane transport protein; Region: Mem_trans; pfam03547
1215914002008	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1215914002009	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1215914002010	Uncharacterized conserved protein [Function unknown]; Region: COG3189
1215914002011	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1215914002012	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
1215914002013	Cl binding site [ion binding]; other site
1215914002014	oligomer interface [polypeptide binding]; other site
1215914002015	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1215914002016	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1215914002017	The substrate binding domain of LysR-type transcriptional regulator MleR which required for malolactic fermentation, contains type 2 periplasmic binidning fold; Region: PBP2_MleR; cd08437
1215914002018	putative dimerization interface [polypeptide binding]; other site
1215914002019	malate dehydrogenase; Provisional; Region: PRK13529
1215914002020	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1215914002021	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
1215914002022	NAD(P) binding site [chemical binding]; other site
1215914002023	Membrane transport protein; Region: Mem_trans; pfam03547
1215914002024	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1215914002025	dimer interface [polypeptide binding]; other site
1215914002026	catalytic triad [active]
1215914002027	peroxidatic and resolving cysteines [active]
1215914002028	Flavodoxin domain; Region: Flavodoxin_5; cl17428
1215914002029	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1215914002030	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914002031	non-specific DNA binding site [nucleotide binding]; other site
1215914002032	salt bridge; other site
1215914002033	sequence-specific DNA binding site [nucleotide binding]; other site
1215914002034	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
1215914002035	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1215914002036	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1215914002037	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1215914002038	Walker A/P-loop; other site
1215914002039	ATP binding site [chemical binding]; other site
1215914002040	Q-loop/lid; other site
1215914002041	ABC transporter signature motif; other site
1215914002042	Walker B; other site
1215914002043	D-loop; other site
1215914002044	H-loop/switch region; other site
1215914002045	oligoendopeptidase F; Region: pepF; TIGR00181
1215914002046	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609
1215914002047	active site
1215914002048	Zn binding site [ion binding]; other site
1215914002049	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1215914002050	glucose-1-dehydrogenase; Provisional; Region: PRK06947
1215914002051	NAD(P) binding site [chemical binding]; other site
1215914002052	active site
1215914002053	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1215914002054	active site
1215914002055	multimer interface [polypeptide binding]; other site
1215914002056	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1215914002057	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
1215914002058	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1215914002059	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
1215914002060	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1215914002061	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1215914002062	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1215914002063	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1215914002064	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1215914002065	motif II; other site
1215914002066	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1215914002067	MarR family; Region: MarR_2; pfam12802
1215914002068	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1215914002069	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1215914002070	flavoprotein NrdI; Provisional; Region: PRK02551
1215914002071	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1215914002072	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1215914002073	active site
1215914002074	catalytic tetrad [active]
1215914002075	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
1215914002076	Predicted membrane protein [Function unknown]; Region: COG2323
1215914002077	Protein of unknown function (DUF3290); Region: DUF3290; pfam11694
1215914002078	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1215914002079	substrate binding site [chemical binding]; other site
1215914002080	THF binding site; other site
1215914002081	zinc-binding site [ion binding]; other site
1215914002082	S-ribosylhomocysteinase; Provisional; Region: PRK02260
1215914002083	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1215914002084	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1215914002085	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1215914002086	RuvA N terminal domain; Region: RuvA_N; pfam01330
1215914002087	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1215914002088	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1215914002089	Walker A motif; other site
1215914002090	ATP binding site [chemical binding]; other site
1215914002091	Walker B motif; other site
1215914002092	arginine finger; other site
1215914002093	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1215914002094	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1215914002095	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1215914002096	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1215914002097	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1215914002098	Preprotein translocase subunit; Region: YajC; pfam02699
1215914002099	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
1215914002100	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1215914002101	putative catalytic cysteine [active]
1215914002102	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
1215914002103	putative active site [active]
1215914002104	metal binding site [ion binding]; metal-binding site
1215914002105	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1215914002106	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
1215914002107	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1215914002108	FeoA domain; Region: FeoA; pfam04023
1215914002109	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1215914002110	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1215914002111	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1215914002112	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1215914002113	active site
1215914002114	DNA polymerase IV; Validated; Region: PRK02406
1215914002115	DNA binding site [nucleotide binding]
1215914002116	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
1215914002117	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1215914002118	DNA-binding site [nucleotide binding]; DNA binding site
1215914002119	DRTGG domain; Region: DRTGG; pfam07085
1215914002120	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1215914002121	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1215914002122	DHH family; Region: DHH; pfam01368
1215914002123	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1215914002124	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1215914002125	ATP binding site [chemical binding]; other site
1215914002126	Mg++ binding site [ion binding]; other site
1215914002127	motif III; other site
1215914002128	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1215914002129	nucleotide binding region [chemical binding]; other site
1215914002130	ATP-binding site [chemical binding]; other site
1215914002131	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1215914002132	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1215914002133	motif 1; other site
1215914002134	active site
1215914002135	motif 2; other site
1215914002136	motif 3; other site
1215914002137	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1215914002138	DHHA1 domain; Region: DHHA1; pfam02272
1215914002139	Protein of unknown function (DUF1343); Region: DUF1343; cl01598
1215914002140	hypothetical protein; Provisional; Region: PRK05473
1215914002141	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1215914002142	hypothetical protein; Provisional; Region: PRK13678
1215914002143	Cell division protein ZapA; Region: ZapA; pfam05164
1215914002144	Colicin V production protein; Region: Colicin_V; pfam02674
1215914002145	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1215914002146	MutS domain III; Region: MutS_III; pfam05192
1215914002147	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914002148	Walker A/P-loop; other site
1215914002149	ATP binding site [chemical binding]; other site
1215914002150	Q-loop/lid; other site
1215914002151	ABC transporter signature motif; other site
1215914002152	Walker B; other site
1215914002153	D-loop; other site
1215914002154	H-loop/switch region; other site
1215914002155	V-type ATP synthase subunit H; Validated; Region: PRK06397
1215914002156	Smr domain; Region: Smr; pfam01713
1215914002157	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1215914002158	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1215914002159	catalytic residues [active]
1215914002160	D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734
1215914002161	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
1215914002162	acyl-activating enzyme (AAE) consensus motif; other site
1215914002163	AMP binding site [chemical binding]; other site
1215914002164	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
1215914002165	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
1215914002166	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
1215914002167	DltD N-terminal region; Region: DltD_N; pfam04915
1215914002168	DltD central region; Region: DltD_M; pfam04918
1215914002169	DltD C-terminal region; Region: DltD_C; pfam04914
1215914002170	Protein of unknown function (DUF2507); Region: DUF2507; pfam10702
1215914002171	glutamate racemase; Provisional; Region: PRK00865
1215914002172	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1215914002173	active site
1215914002174	dimerization interface [polypeptide binding]; other site
1215914002175	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1215914002176	active site
1215914002177	metal binding site [ion binding]; metal-binding site
1215914002178	homotetramer interface [polypeptide binding]; other site
1215914002179	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1215914002180	amphipathic channel; other site
1215914002181	Asn-Pro-Ala signature motifs; other site
1215914002182	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
1215914002183	FOG: CBS domain [General function prediction only]; Region: COG0517
1215914002184	Domain of unknown function (DUF368); Region: DUF368; pfam04018
1215914002185	Domain of unknown function (DUF368); Region: DUF368; cl00893
1215914002186	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1215914002187	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1215914002188	Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103
1215914002189	YtxH-like protein; Region: YtxH; pfam12732
1215914002190	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
1215914002191	HTH domain; Region: HTH_11; pfam08279
1215914002192	3H domain; Region: 3H; pfam02829
1215914002193	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1215914002194	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1215914002195	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1215914002196	active site
1215914002197	catabolite control protein A; Region: ccpA; TIGR01481
1215914002198	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1215914002199	DNA binding site [nucleotide binding]
1215914002200	domain linker motif; other site
1215914002201	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
1215914002202	dimerization interface [polypeptide binding]; other site
1215914002203	effector binding site; other site
1215914002204	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1215914002205	Helix-turn-helix domain; Region: HTH_38; pfam13936
1215914002206	Homeodomain-like domain; Region: HTH_32; pfam13565
1215914002207	Integrase core domain; Region: rve; pfam00665
1215914002208	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1215914002209	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1215914002210	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
1215914002211	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1215914002212	motif II; other site
1215914002213	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1215914002214	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1215914002215	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1215914002216	dipeptidase PepV; Reviewed; Region: PRK07318
1215914002217	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1215914002218	active site
1215914002219	metal binding site [ion binding]; metal-binding site
1215914002220	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1215914002221	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
1215914002222	active site
1215914002223	catalytic site [active]
1215914002224	metal binding site [ion binding]; metal-binding site
1215914002225	YibE/F-like protein; Region: YibE_F; cl02259
1215914002226	YibE/F-like protein; Region: YibE_F; pfam07907
1215914002227	YibE/F-like protein; Region: YibE_F; pfam07907
1215914002228	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
1215914002229	putative active site [active]
1215914002230	putative metal binding site [ion binding]; other site
1215914002231	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1215914002232	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1215914002233	active site
1215914002234	metal binding site [ion binding]; metal-binding site
1215914002235	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1215914002236	Protein of unknown function (DUF1027); Region: DUF1027; pfam06265
1215914002237	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
1215914002238	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1215914002239	active site
1215914002240	motif I; other site
1215914002241	motif II; other site
1215914002242	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1215914002243	Protein of unknown function (DUF1461); Region: DUF1461; pfam07314
1215914002244	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1215914002245	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1215914002246	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1215914002247	tetramer interfaces [polypeptide binding]; other site
1215914002248	binuclear metal-binding site [ion binding]; other site
1215914002249	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1215914002250	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1215914002251	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1215914002252	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
1215914002253	active site
1215914002254	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164
1215914002255	RNA binding site [nucleotide binding]; other site
1215914002256	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1215914002257	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1215914002258	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1215914002259	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1215914002260	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1215914002261	RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984
1215914002262	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1215914002263	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1215914002264	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1215914002265	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
1215914002266	putative ADP-binding pocket [chemical binding]; other site
1215914002267	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1215914002268	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1215914002269	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1215914002270	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
1215914002271	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
1215914002272	aromatic amino acid aminotransferase; Validated; Region: PRK07309
1215914002273	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1215914002274	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1215914002275	homodimer interface [polypeptide binding]; other site
1215914002276	catalytic residue [active]
1215914002277	Protein of unknown function (DUF1797); Region: DUF1797; pfam08796
1215914002278	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1215914002279	Sulfatase; Region: Sulfatase; pfam00884
1215914002280	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1215914002281	metal binding site 2 [ion binding]; metal-binding site
1215914002282	putative DNA binding helix; other site
1215914002283	metal binding site 1 [ion binding]; metal-binding site
1215914002284	dimer interface [polypeptide binding]; other site
1215914002285	structural Zn2+ binding site [ion binding]; other site
1215914002286	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1215914002287	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1215914002288	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1215914002289	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1215914002290	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1215914002291	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914002292	putative substrate translocation pore; other site
1215914002293	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1215914002294	DNA binding residues [nucleotide binding]
1215914002295	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1215914002296	putative dimer interface [polypeptide binding]; other site
1215914002297	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914002298	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1215914002299	putative substrate translocation pore; other site
1215914002300	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914002301	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1215914002302	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1215914002303	active site
1215914002304	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1215914002305	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1215914002306	HIGH motif; other site
1215914002307	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1215914002308	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1215914002309	active site
1215914002310	KMSKS motif; other site
1215914002311	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1215914002312	tRNA binding surface [nucleotide binding]; other site
1215914002313	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1215914002314	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1215914002315	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1215914002316	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1215914002317	RNA binding surface [nucleotide binding]; other site
1215914002318	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1215914002319	active site
1215914002320	uracil binding [chemical binding]; other site
1215914002321	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855
1215914002322	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1215914002323	putative substrate binding site [chemical binding]; other site
1215914002324	putative ATP binding site [chemical binding]; other site
1215914002325	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
1215914002326	nudix motif; other site
1215914002327	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1215914002328	Int/Topo IB signature motif; other site
1215914002329	Abi-like protein; Region: Abi_2; pfam07751
1215914002330	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
1215914002331	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1215914002332	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1215914002333	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914002334	non-specific DNA binding site [nucleotide binding]; other site
1215914002335	salt bridge; other site
1215914002336	sequence-specific DNA binding site [nucleotide binding]; other site
1215914002337	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
1215914002338	Domain of unknown function (DUF771); Region: DUF771; cl09962
1215914002339	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
1215914002340	RecT family; Region: RecT; cl04285
1215914002341	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1215914002342	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914002343	non-specific DNA binding site [nucleotide binding]; other site
1215914002344	salt bridge; other site
1215914002345	sequence-specific DNA binding site [nucleotide binding]; other site
1215914002346	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1215914002347	DNA-binding site [nucleotide binding]; DNA binding site
1215914002348	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
1215914002349	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
1215914002350	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1215914002351	Walker A motif; other site
1215914002352	ATP binding site [chemical binding]; other site
1215914002353	Walker B motif; other site
1215914002354	HNH endonuclease; Region: HNH_3; pfam13392
1215914002355	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
1215914002356	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1215914002357	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
1215914002358	DNA binding residues [nucleotide binding]
1215914002359	HNH endonuclease; Region: HNH; pfam01844
1215914002360	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
1215914002361	Phage-related protein [Function unknown]; Region: COG4695; cl01923
1215914002362	Phage portal protein; Region: Phage_portal; pfam04860
1215914002363	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
1215914002364	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
1215914002365	oligomer interface [polypeptide binding]; other site
1215914002366	active site residues [active]
1215914002367	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
1215914002368	Phage capsid family; Region: Phage_capsid; pfam05065
1215914002369	Phage head-tail joining protein; Region: Phage_H_T_join; cl11461
1215914002370	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
1215914002371	Tropomyosin like; Region: Tropomyosin_1; pfam12718
1215914002372	tape measure domain; Region: tape_meas_nterm; TIGR02675
1215914002373	Phage-related protein [Function unknown]; Region: COG5412
1215914002374	Phage-related protein [Function unknown]; Region: COG4722
1215914002375	Phage tail protein; Region: Sipho_tail; cl17486
1215914002376	Phage-related protein [Function unknown]; Region: PblB; COG4926
1215914002377	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
1215914002378	Protein of unknown function (DUF1617); Region: DUF1617; pfam07761
1215914002379	Bacteriophage holin; Region: Phage_holin_1; pfam04531
1215914002380	Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382
1215914002381	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1215914002382	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1215914002383	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1215914002384	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
1215914002385	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1215914002386	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1215914002387	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1215914002388	catalytic residues [active]
1215914002389	dimer interface [polypeptide binding]; other site
1215914002390	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1215914002391	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1215914002392	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1215914002393	homodimer interface [polypeptide binding]; other site
1215914002394	catalytic residue [active]
1215914002395	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1215914002396	Helix-turn-helix domain; Region: HTH_38; pfam13936
1215914002397	Integrase core domain; Region: rve; pfam00665
1215914002398	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1215914002399	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1215914002400	active site
1215914002401	metal binding site [ion binding]; metal-binding site
1215914002402	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
1215914002403	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
1215914002404	Competence protein CoiA-like family; Region: CoiA; cl11541
1215914002405	Thioredoxin; Region: Thioredoxin_5; pfam13743
1215914002406	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
1215914002407	putative active site [active]
1215914002408	putative metal binding residues [ion binding]; other site
1215914002409	signature motif; other site
1215914002410	putative triphosphate binding site [ion binding]; other site
1215914002411	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1215914002412	synthetase active site [active]
1215914002413	NTP binding site [chemical binding]; other site
1215914002414	metal binding site [ion binding]; metal-binding site
1215914002415	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
1215914002416	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1215914002417	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1215914002418	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1215914002419	RNA binding surface [nucleotide binding]; other site
1215914002420	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1215914002421	active site
1215914002422	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
1215914002423	ApbE family; Region: ApbE; pfam02424
1215914002424	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
1215914002425	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1215914002426	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1215914002427	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829
1215914002428	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1215914002429	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
1215914002430	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1215914002431	active site
1215914002432	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1215914002433	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
1215914002434	Cl binding site [ion binding]; other site
1215914002435	oligomer interface [polypeptide binding]; other site
1215914002436	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1215914002437	Protein of unknown function (DUF1149); Region: DUF1149; pfam06619
1215914002438	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1215914002439	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1215914002440	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1215914002441	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1215914002442	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1215914002443	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1215914002444	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1215914002445	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1215914002446	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1215914002447	classical (c) SDRs; Region: SDR_c; cd05233
1215914002448	NAD(P) binding site [chemical binding]; other site
1215914002449	active site
1215914002450	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
1215914002451	Helix-turn-helix domain; Region: HTH_25; pfam13413
1215914002452	non-specific DNA binding site [nucleotide binding]; other site
1215914002453	salt bridge; other site
1215914002454	sequence-specific DNA binding site [nucleotide binding]; other site
1215914002455	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
1215914002456	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
1215914002457	competence damage-inducible protein A; Provisional; Region: PRK00549
1215914002458	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1215914002459	putative MPT binding site; other site
1215914002460	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
1215914002461	recombinase A; Provisional; Region: recA; PRK09354
1215914002462	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1215914002463	hexamer interface [polypeptide binding]; other site
1215914002464	Walker A motif; other site
1215914002465	ATP binding site [chemical binding]; other site
1215914002466	Walker B motif; other site
1215914002467	Domain of unknown function (DUF3552); Region: DUF3552; pfam12072
1215914002468	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1215914002469	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1215914002470	Zn2+ binding site [ion binding]; other site
1215914002471	Mg2+ binding site [ion binding]; other site
1215914002472	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1215914002473	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1215914002474	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1215914002475	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
1215914002476	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1215914002477	ATP binding site [chemical binding]; other site
1215914002478	putative Mg++ binding site [ion binding]; other site
1215914002479	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1215914002480	nucleotide binding region [chemical binding]; other site
1215914002481	ATP-binding site [chemical binding]; other site
1215914002482	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1215914002483	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1215914002484	active site
1215914002485	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1215914002486	30S subunit binding site; other site
1215914002487	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906
1215914002488	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1215914002489	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1215914002490	nucleotide binding region [chemical binding]; other site
1215914002491	ATP-binding site [chemical binding]; other site
1215914002492	peptide chain release factor 2; Validated; Region: prfB; PRK00578
1215914002493	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
1215914002494	PCRF domain; Region: PCRF; pfam03462
1215914002495	RF-1 domain; Region: RF-1; pfam00472
1215914002496	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1215914002497	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914002498	Walker A/P-loop; other site
1215914002499	ATP binding site [chemical binding]; other site
1215914002500	Q-loop/lid; other site
1215914002501	ABC transporter signature motif; other site
1215914002502	Walker B; other site
1215914002503	D-loop; other site
1215914002504	H-loop/switch region; other site
1215914002505	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1215914002506	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
1215914002507	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1215914002508	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1215914002509	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1215914002510	active site
1215914002511	phosphorylation site [posttranslational modification]
1215914002512	intermolecular recognition site; other site
1215914002513	dimerization interface [polypeptide binding]; other site
1215914002514	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1215914002515	DNA binding site [nucleotide binding]
1215914002516	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1215914002517	PAS domain; Region: PAS_8; pfam13188
1215914002518	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1215914002519	dimer interface [polypeptide binding]; other site
1215914002520	phosphorylation site [posttranslational modification]
1215914002521	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1215914002522	ATP binding site [chemical binding]; other site
1215914002523	Mg2+ binding site [ion binding]; other site
1215914002524	G-X-G motif; other site
1215914002525	phosphate binding protein; Region: ptsS_2; TIGR02136
1215914002526	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1215914002527	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1215914002528	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914002529	dimer interface [polypeptide binding]; other site
1215914002530	conserved gate region; other site
1215914002531	putative PBP binding loops; other site
1215914002532	ABC-ATPase subunit interface; other site
1215914002533	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1215914002534	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914002535	dimer interface [polypeptide binding]; other site
1215914002536	conserved gate region; other site
1215914002537	putative PBP binding loops; other site
1215914002538	ABC-ATPase subunit interface; other site
1215914002539	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
1215914002540	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1215914002541	Walker A/P-loop; other site
1215914002542	ATP binding site [chemical binding]; other site
1215914002543	Q-loop/lid; other site
1215914002544	ABC transporter signature motif; other site
1215914002545	Walker B; other site
1215914002546	D-loop; other site
1215914002547	H-loop/switch region; other site
1215914002548	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14255
1215914002549	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1215914002550	Walker A/P-loop; other site
1215914002551	ATP binding site [chemical binding]; other site
1215914002552	Q-loop/lid; other site
1215914002553	ABC transporter signature motif; other site
1215914002554	Walker B; other site
1215914002555	D-loop; other site
1215914002556	H-loop/switch region; other site
1215914002557	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1215914002558	PhoU domain; Region: PhoU; pfam01895
1215914002559	PhoU domain; Region: PhoU; pfam01895
1215914002560	Uncharacterized conserved protein [Function unknown]; Region: COG3595
1215914002561	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1215914002562	Membrane protein of unknown function; Region: DUF360; pfam04020
1215914002563	HPr kinase/phosphorylase; Provisional; Region: PRK05428
1215914002564	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
1215914002565	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
1215914002566	Hpr binding site; other site
1215914002567	active site
1215914002568	homohexamer subunit interaction site [polypeptide binding]; other site
1215914002569	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
1215914002570	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1215914002571	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1215914002572	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1215914002573	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1215914002574	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1215914002575	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1215914002576	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
1215914002577	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1215914002578	active site
1215914002579	substrate binding site [chemical binding]; other site
1215914002580	metal binding site [ion binding]; metal-binding site
1215914002581	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1215914002582	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1215914002583	active site
1215914002584	phosphorylation site [posttranslational modification]
1215914002585	intermolecular recognition site; other site
1215914002586	dimerization interface [polypeptide binding]; other site
1215914002587	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1215914002588	DNA binding site [nucleotide binding]
1215914002589	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1215914002590	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
1215914002591	dimer interface [polypeptide binding]; other site
1215914002592	phosphorylation site [posttranslational modification]
1215914002593	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1215914002594	ATP binding site [chemical binding]; other site
1215914002595	Mg2+ binding site [ion binding]; other site
1215914002596	G-X-G motif; other site
1215914002597	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914002598	Walker A/P-loop; other site
1215914002599	ATP binding site [chemical binding]; other site
1215914002600	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1215914002601	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1215914002602	Q-loop/lid; other site
1215914002603	ABC transporter signature motif; other site
1215914002604	Walker B; other site
1215914002605	D-loop; other site
1215914002606	H-loop/switch region; other site
1215914002607	FtsX-like permease family; Region: FtsX; pfam02687
1215914002608	HD domain; Region: HD_3; cl17350
1215914002609	excinuclease ABC subunit B; Provisional; Region: PRK05298
1215914002610	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1215914002611	ATP binding site [chemical binding]; other site
1215914002612	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1215914002613	nucleotide binding region [chemical binding]; other site
1215914002614	ATP-binding site [chemical binding]; other site
1215914002615	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1215914002616	UvrB/uvrC motif; Region: UVR; pfam02151
1215914002617	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1215914002618	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1215914002619	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1215914002620	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1215914002621	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
1215914002622	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1215914002623	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1215914002624	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1215914002625	phosphate binding site [ion binding]; other site
1215914002626	putative substrate binding pocket [chemical binding]; other site
1215914002627	dimer interface [polypeptide binding]; other site
1215914002628	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1215914002629	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1215914002630	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1215914002631	MarR family; Region: MarR; pfam01047
1215914002632	Clp protease; Region: CLP_protease; pfam00574
1215914002633	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1215914002634	oligomer interface [polypeptide binding]; other site
1215914002635	active site residues [active]
1215914002636	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1215914002637	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1215914002638	Int/Topo IB signature motif; other site
1215914002639	Ion transport protein; Region: Ion_trans; pfam00520
1215914002640	Ion channel; Region: Ion_trans_2; pfam07885
1215914002641	Short C-terminal domain; Region: SHOCT; pfam09851
1215914002642	Domain of unknown function (DUF955); Region: DUF955; cl01076
1215914002643	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1215914002644	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914002645	non-specific DNA binding site [nucleotide binding]; other site
1215914002646	salt bridge; other site
1215914002647	sequence-specific DNA binding site [nucleotide binding]; other site
1215914002648	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1215914002649	sequence-specific DNA binding site [nucleotide binding]; other site
1215914002650	salt bridge; other site
1215914002651	ORF6N domain; Region: ORF6N; pfam10543
1215914002652	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
1215914002653	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
1215914002654	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1215914002655	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1215914002656	ATP binding site [chemical binding]; other site
1215914002657	putative Mg++ binding site [ion binding]; other site
1215914002658	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1215914002659	nucleotide binding region [chemical binding]; other site
1215914002660	ATP-binding site [chemical binding]; other site
1215914002661	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
1215914002662	nucleotide binding site [chemical binding]; other site
1215914002663	polymerase nucleotide-binding site; other site
1215914002664	primase nucleotide-binding site [nucleotide binding]; other site
1215914002665	DNA-binding residues [nucleotide binding]; DNA binding site
1215914002666	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
1215914002667	Virulence-associated protein E; Region: VirE; pfam05272
1215914002668	VRR-NUC domain; Region: VRR_NUC; pfam08774
1215914002669	HNH endonuclease; Region: HNH_3; pfam13392
1215914002670	phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636
1215914002671	HNH endonuclease; Region: HNH; pfam01844
1215914002672	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
1215914002673	Phage-related protein [Function unknown]; Region: COG4695; cl01923
1215914002674	Phage portal protein; Region: Phage_portal; pfam04860
1215914002675	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
1215914002676	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
1215914002677	oligomer interface [polypeptide binding]; other site
1215914002678	active site residues [active]
1215914002679	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
1215914002680	Phage capsid family; Region: Phage_capsid; pfam05065
1215914002681	Phage head-tail joining protein; Region: Phage_H_T_join; cl11461
1215914002682	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
1215914002683	Phage-related minor tail protein [Function unknown]; Region: COG5280
1215914002684	Phage-related protein [Function unknown]; Region: COG5412
1215914002685	Phage-related protein [Function unknown]; Region: COG4722
1215914002686	Phage tail protein; Region: Sipho_tail; cl17486
1215914002687	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
1215914002688	Protein of unknown function (DUF1617); Region: DUF1617; pfam07761
1215914002689	Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890
1215914002690	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1215914002691	amidase catalytic site [active]
1215914002692	Zn binding residues [ion binding]; other site
1215914002693	substrate binding site [chemical binding]; other site
1215914002694	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1215914002695	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1215914002696	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
1215914002697	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1215914002698	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1215914002699	Phosphoglycerate kinase; Region: PGK; pfam00162
1215914002700	substrate binding site [chemical binding]; other site
1215914002701	hinge regions; other site
1215914002702	ADP binding site [chemical binding]; other site
1215914002703	catalytic site [active]
1215914002704	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1215914002705	triosephosphate isomerase; Provisional; Region: PRK14567
1215914002706	substrate binding site [chemical binding]; other site
1215914002707	dimer interface [polypeptide binding]; other site
1215914002708	catalytic triad [active]
1215914002709	enolase; Provisional; Region: eno; PRK00077
1215914002710	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1215914002711	dimer interface [polypeptide binding]; other site
1215914002712	metal binding site [ion binding]; metal-binding site
1215914002713	substrate binding pocket [chemical binding]; other site
1215914002714	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914002715	H+ Antiporter protein; Region: 2A0121; TIGR00900
1215914002716	putative substrate translocation pore; other site
1215914002717	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
1215914002718	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1215914002719	Cl- selectivity filter; other site
1215914002720	Cl- binding residues [ion binding]; other site
1215914002721	pore gating glutamate residue; other site
1215914002722	dimer interface [polypeptide binding]; other site
1215914002723	H+/Cl- coupling transport residue; other site
1215914002724	TrkA-C domain; Region: TrkA_C; pfam02080
1215914002725	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
1215914002726	Esterase/lipase [General function prediction only]; Region: COG1647
1215914002727	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1215914002728	ribonuclease R; Region: RNase_R; TIGR02063
1215914002729	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1215914002730	RNB domain; Region: RNB; pfam00773
1215914002731	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1215914002732	RNA binding site [nucleotide binding]; other site
1215914002733	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1215914002734	SmpB-tmRNA interface; other site
1215914002735	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1215914002736	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1215914002737	DNA binding site [nucleotide binding]
1215914002738	domain linker motif; other site
1215914002739	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1215914002740	ligand binding site [chemical binding]; other site
1215914002741	dimerization interface [polypeptide binding]; other site
1215914002742	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1215914002743	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1215914002744	active site
1215914002745	catalytic site [active]
1215914002746	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
1215914002747	homodimer interface [polypeptide binding]; other site
1215914002748	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1215914002749	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1215914002750	active site
1215914002751	homodimer interface [polypeptide binding]; other site
1215914002752	catalytic site [active]
1215914002753	maltose phosphorylase; Provisional; Region: PRK13807
1215914002754	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
1215914002755	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
1215914002756	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
1215914002757	beta-phosphoglucomutase; Region: bPGM; TIGR01990
1215914002758	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1215914002759	motif II; other site
1215914002760	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1215914002761	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1215914002762	Walker A/P-loop; other site
1215914002763	ATP binding site [chemical binding]; other site
1215914002764	Q-loop/lid; other site
1215914002765	ABC transporter signature motif; other site
1215914002766	Walker B; other site
1215914002767	D-loop; other site
1215914002768	H-loop/switch region; other site
1215914002769	TOBE domain; Region: TOBE_2; pfam08402
1215914002770	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1215914002771	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1215914002772	Ca binding site [ion binding]; other site
1215914002773	active site
1215914002774	catalytic site [active]
1215914002775	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
1215914002776	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1215914002777	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1215914002778	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914002779	dimer interface [polypeptide binding]; other site
1215914002780	conserved gate region; other site
1215914002781	putative PBP binding loops; other site
1215914002782	ABC-ATPase subunit interface; other site
1215914002783	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1215914002784	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914002785	dimer interface [polypeptide binding]; other site
1215914002786	conserved gate region; other site
1215914002787	ABC-ATPase subunit interface; other site
1215914002788	ATP synthase regulation protein NCA2; Region: NCA2; pfam08637
1215914002789	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1215914002790	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914002791	non-specific DNA binding site [nucleotide binding]; other site
1215914002792	salt bridge; other site
1215914002793	sequence-specific DNA binding site [nucleotide binding]; other site
1215914002794	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1215914002795	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1215914002796	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1215914002797	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1215914002798	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1215914002799	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1215914002800	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914002801	dimer interface [polypeptide binding]; other site
1215914002802	conserved gate region; other site
1215914002803	putative PBP binding loops; other site
1215914002804	ABC-ATPase subunit interface; other site
1215914002805	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914002806	dimer interface [polypeptide binding]; other site
1215914002807	conserved gate region; other site
1215914002808	putative PBP binding loops; other site
1215914002809	ABC-ATPase subunit interface; other site
1215914002810	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1215914002811	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914002812	Walker A/P-loop; other site
1215914002813	ATP binding site [chemical binding]; other site
1215914002814	Q-loop/lid; other site
1215914002815	ABC transporter signature motif; other site
1215914002816	Walker B; other site
1215914002817	D-loop; other site
1215914002818	H-loop/switch region; other site
1215914002819	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1215914002820	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1215914002821	Coenzyme A binding pocket [chemical binding]; other site
1215914002822	Tubby C 2; Region: Tub_2; cl02043
1215914002823	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1215914002824	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1215914002825	active site
1215914002826	motif I; other site
1215914002827	motif II; other site
1215914002828	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1215914002829	ligand binding site [chemical binding]; other site
1215914002830	active site
1215914002831	UGI interface [polypeptide binding]; other site
1215914002832	catalytic site [active]
1215914002833	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1215914002834	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1215914002835	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1215914002836	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914002837	Walker A/P-loop; other site
1215914002838	ATP binding site [chemical binding]; other site
1215914002839	Q-loop/lid; other site
1215914002840	ABC transporter signature motif; other site
1215914002841	Walker B; other site
1215914002842	D-loop; other site
1215914002843	H-loop/switch region; other site
1215914002844	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1215914002845	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1215914002846	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
1215914002847	active site
1215914002848	catalytic site [active]
1215914002849	substrate binding site [chemical binding]; other site
1215914002850	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
1215914002851	active site
1215914002852	putative catalytic site [active]
1215914002853	DNA binding site [nucleotide binding]
1215914002854	putative phosphate binding site [ion binding]; other site
1215914002855	metal binding site A [ion binding]; metal-binding site
1215914002856	AP binding site [nucleotide binding]; other site
1215914002857	metal binding site B [ion binding]; metal-binding site
1215914002858	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
1215914002859	FAD binding domain; Region: FAD_binding_4; pfam01565
1215914002860	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1215914002861	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1215914002862	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1215914002863	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1215914002864	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914002865	non-specific DNA binding site [nucleotide binding]; other site
1215914002866	salt bridge; other site
1215914002867	sequence-specific DNA binding site [nucleotide binding]; other site
1215914002868	Cupin domain; Region: Cupin_2; pfam07883
1215914002869	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1215914002870	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
1215914002871	Walker A/P-loop; other site
1215914002872	ATP binding site [chemical binding]; other site
1215914002873	Q-loop/lid; other site
1215914002874	ABC transporter signature motif; other site
1215914002875	Walker B; other site
1215914002876	D-loop; other site
1215914002877	H-loop/switch region; other site
1215914002878	TOBE domain; Region: TOBE_2; pfam08402
1215914002879	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1215914002880	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914002881	dimer interface [polypeptide binding]; other site
1215914002882	conserved gate region; other site
1215914002883	putative PBP binding loops; other site
1215914002884	ABC-ATPase subunit interface; other site
1215914002885	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1215914002886	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914002887	dimer interface [polypeptide binding]; other site
1215914002888	conserved gate region; other site
1215914002889	putative PBP binding loops; other site
1215914002890	ABC-ATPase subunit interface; other site
1215914002891	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1215914002892	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1215914002893	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1215914002894	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1215914002895	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1215914002896	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1215914002897	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1215914002898	motif II; other site
1215914002899	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1215914002900	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1215914002901	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1215914002902	PXA domain; Region: PXA; cl02564
1215914002903	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1215914002904	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1215914002905	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
1215914002906	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1215914002907	Walker A/P-loop; other site
1215914002908	ATP binding site [chemical binding]; other site
1215914002909	Q-loop/lid; other site
1215914002910	ABC transporter signature motif; other site
1215914002911	Walker B; other site
1215914002912	D-loop; other site
1215914002913	H-loop/switch region; other site
1215914002914	Uncharacterized conserved protein [Function unknown]; Region: COG1624
1215914002915	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1215914002916	YbbR-like protein; Region: YbbR; pfam07949
1215914002917	YbbR-like protein; Region: YbbR; pfam07949
1215914002918	YbbR-like protein; Region: YbbR; pfam07949
1215914002919	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
1215914002920	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1215914002921	active site
1215914002922	substrate binding site [chemical binding]; other site
1215914002923	metal binding site [ion binding]; metal-binding site
1215914002924	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1215914002925	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1215914002926	glutaminase active site [active]
1215914002927	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1215914002928	dimer interface [polypeptide binding]; other site
1215914002929	active site
1215914002930	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1215914002931	dimer interface [polypeptide binding]; other site
1215914002932	active site
1215914002933	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
1215914002934	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
1215914002935	active site
1215914002936	Zn binding site [ion binding]; other site
1215914002937	hypothetical protein; Validated; Region: PRK00110
1215914002938	Type II/IV secretion system protein; Region: T2SE; pfam00437
1215914002939	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1215914002940	Walker A motif; other site
1215914002941	ATP binding site [chemical binding]; other site
1215914002942	Walker B motif; other site
1215914002943	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1215914002944	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
1215914002945	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
1215914002946	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
1215914002947	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1215914002948	S-adenosylmethionine binding site [chemical binding]; other site
1215914002949	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1215914002950	Spore germination protein; Region: Spore_permease; cl17796
1215914002951	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1215914002952	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1215914002953	putative acyl-acceptor binding pocket; other site
1215914002954	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
1215914002955	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
1215914002956	Ligand binding site; other site
1215914002957	metal-binding site
1215914002958	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
1215914002959	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
1215914002960	Ligand binding site; other site
1215914002961	metal-binding site
1215914002962	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1215914002963	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1215914002964	putative acyl-acceptor binding pocket; other site
1215914002965	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
1215914002966	Melibiase; Region: Melibiase; pfam02065
1215914002967	5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739
1215914002968	SdpI/YhfL protein family; Region: SdpI; pfam13630
1215914002969	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1215914002970	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1215914002971	active site
1215914002972	phosphorylation site [posttranslational modification]
1215914002973	intermolecular recognition site; other site
1215914002974	dimerization interface [polypeptide binding]; other site
1215914002975	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1215914002976	DNA binding site [nucleotide binding]
1215914002977	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1215914002978	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1215914002979	dimerization interface [polypeptide binding]; other site
1215914002980	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1215914002981	dimer interface [polypeptide binding]; other site
1215914002982	phosphorylation site [posttranslational modification]
1215914002983	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1215914002984	ATP binding site [chemical binding]; other site
1215914002985	Mg2+ binding site [ion binding]; other site
1215914002986	G-X-G motif; other site
1215914002987	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1215914002988	Predicted acetyltransferase [General function prediction only]; Region: COG3153
1215914002989	hypothetical protein; Provisional; Region: PRK04435
1215914002990	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1215914002991	DNA-binding interface [nucleotide binding]; DNA binding site
1215914002992	C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888
1215914002993	DNA polymerase IV; Reviewed; Region: PRK03103
1215914002994	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
1215914002995	active site
1215914002996	DNA binding site [nucleotide binding]
1215914002997	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1215914002998	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1215914002999	Double zinc ribbon; Region: DZR; pfam12773
1215914003000	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1215914003001	active site
1215914003002	catalytic triad [active]
1215914003003	oxyanion hole [active]
1215914003004	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1215914003005	Part of AAA domain; Region: AAA_19; pfam13245
1215914003006	Family description; Region: UvrD_C_2; pfam13538
1215914003007	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1215914003008	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1215914003009	nucleotide binding pocket [chemical binding]; other site
1215914003010	K-X-D-G motif; other site
1215914003011	catalytic site [active]
1215914003012	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1215914003013	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1215914003014	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1215914003015	Dimer interface [polypeptide binding]; other site
1215914003016	BRCT sequence motif; other site
1215914003017	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
1215914003018	putative dimer interface [polypeptide binding]; other site
1215914003019	CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537
1215914003020	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
1215914003021	putative dimer interface [polypeptide binding]; other site
1215914003022	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1215914003023	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1215914003024	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1215914003025	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1215914003026	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1215914003027	GatB domain; Region: GatB_Yqey; smart00845
1215914003028	putative lipid kinase; Reviewed; Region: PRK13055
1215914003029	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1215914003030	TRAM domain; Region: TRAM; pfam01938
1215914003031	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1215914003032	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1215914003033	S-adenosylmethionine binding site [chemical binding]; other site
1215914003034	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914003035	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1215914003036	putative substrate translocation pore; other site
1215914003037	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1215914003038	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1215914003039	active site
1215914003040	motif I; other site
1215914003041	motif II; other site
1215914003042	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1215914003043	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
1215914003044	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
1215914003045	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
1215914003046	active site
1215914003047	Zn binding site [ion binding]; other site
1215914003048	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914003049	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1215914003050	putative substrate translocation pore; other site
1215914003051	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1215914003052	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1215914003053	Coenzyme A binding pocket [chemical binding]; other site
1215914003054	EDD domain protein, DegV family; Region: DegV; TIGR00762
1215914003055	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1215914003056	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1215914003057	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1215914003058	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419
1215914003059	active site
1215914003060	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1215914003061	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
1215914003062	formate dehydrogenase; Provisional; Region: PRK07574
1215914003063	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
1215914003064	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1215914003065	ATP binding site [chemical binding]; other site
1215914003066	putative Mg++ binding site [ion binding]; other site
1215914003067	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1215914003068	nucleotide binding region [chemical binding]; other site
1215914003069	ATP-binding site [chemical binding]; other site
1215914003070	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166
1215914003071	active site
1215914003072	methionine cluster; other site
1215914003073	phosphorylation site [posttranslational modification]
1215914003074	metal binding site [ion binding]; metal-binding site
1215914003075	Domain of unknown function (DUF3284); Region: DUF3284; pfam11687
1215914003076	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
1215914003077	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1215914003078	ATP binding site [chemical binding]; other site
1215914003079	putative Mg++ binding site [ion binding]; other site
1215914003080	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1215914003081	nucleotide binding region [chemical binding]; other site
1215914003082	ATP-binding site [chemical binding]; other site
1215914003083	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1215914003084	HRDC domain; Region: HRDC; pfam00570
1215914003085	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1215914003086	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1215914003087	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1215914003088	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1215914003089	WHG domain; Region: WHG; pfam13305
1215914003090	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
1215914003091	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
1215914003092	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1215914003093	flavodoxin; Validated; Region: PRK07308
1215914003094	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1215914003095	active site
1215914003096	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1215914003097	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1215914003098	active site
1215914003099	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
1215914003100	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
1215914003101	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1215914003102	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1215914003103	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1215914003104	active site
1215914003105	tetramer interface; other site
1215914003106	putative transposase OrfB; Reviewed; Region: PHA02517
1215914003107	HTH-like domain; Region: HTH_21; pfam13276
1215914003108	Integrase core domain; Region: rve; pfam00665
1215914003109	Integrase core domain; Region: rve_3; pfam13683
1215914003110	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
1215914003111	active site
1215914003112	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1215914003113	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1215914003114	NAD(P) binding site [chemical binding]; other site
1215914003115	active site
1215914003116	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1215914003117	Helix-turn-helix domain; Region: HTH_38; pfam13936
1215914003118	Integrase core domain; Region: rve; pfam00665
1215914003119	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
1215914003120	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
1215914003121	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1215914003122	beta-galactosidase; Region: BGL; TIGR03356
1215914003123	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
1215914003124	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1215914003125	active site turn [active]
1215914003126	phosphorylation site [posttranslational modification]
1215914003127	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1215914003128	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1215914003129	HPr interaction site; other site
1215914003130	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1215914003131	active site
1215914003132	phosphorylation site [posttranslational modification]
1215914003133	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1215914003134	CAT RNA binding domain; Region: CAT_RBD; smart01061
1215914003135	PRD domain; Region: PRD; pfam00874
1215914003136	PRD domain; Region: PRD; pfam00874
1215914003137	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
1215914003138	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
1215914003139	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1215914003140	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1215914003141	Ligand binding site; other site
1215914003142	Putative Catalytic site; other site
1215914003143	DXD motif; other site
1215914003144	Predicted membrane protein [Function unknown]; Region: COG4129
1215914003145	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1215914003146	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
1215914003147	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1215914003148	DNA-binding site [nucleotide binding]; DNA binding site
1215914003149	RNA-binding motif; other site
1215914003150	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1215914003151	Coenzyme A binding pocket [chemical binding]; other site
1215914003152	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
1215914003153	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1215914003154	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1215914003155	active site
1215914003156	xanthine permease; Region: pbuX; TIGR03173
1215914003157	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1215914003158	adenylosuccinate lyase; Provisional; Region: PRK07492
1215914003159	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1215914003160	tetramer interface [polypeptide binding]; other site
1215914003161	active site
1215914003162	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1215914003163	Sulfatase; Region: Sulfatase; pfam00884
1215914003164	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
1215914003165	Sugar transport protein; Region: Sugar_transport; pfam06800
1215914003166	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
1215914003167	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1215914003168	active site
1215914003169	dimer interface [polypeptide binding]; other site
1215914003170	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1215914003171	dimer interface [polypeptide binding]; other site
1215914003172	active site
1215914003173	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1215914003174	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1215914003175	Int/Topo IB signature motif; other site
1215914003176	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1215914003177	Domain of unknown function (DUF4041); Region: DUF4041; pfam13250
1215914003178	This entry represents the putative helicase A859L; Region: T5orf172; smart00974
1215914003179	Domain of unknown function (DUF955); Region: DUF955; cl01076
1215914003180	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1215914003181	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914003182	non-specific DNA binding site [nucleotide binding]; other site
1215914003183	salt bridge; other site
1215914003184	sequence-specific DNA binding site [nucleotide binding]; other site
1215914003185	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1215914003186	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914003187	non-specific DNA binding site [nucleotide binding]; other site
1215914003188	salt bridge; other site
1215914003189	sequence-specific DNA binding site [nucleotide binding]; other site
1215914003190	Thylakoid formation protein; Region: ThylakoidFormat; cl12138
1215914003191	Helix-turn-helix domain; Region: HTH_17; cl17695
1215914003192	RecT family; Region: RecT; cl04285
1215914003193	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
1215914003194	Helix-turn-helix domain; Region: HTH_36; pfam13730
1215914003195	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
1215914003196	Hypothetical protein (DUF2513); Region: DUF2513; pfam10711
1215914003197	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914003198	non-specific DNA binding site [nucleotide binding]; other site
1215914003199	salt bridge; other site
1215914003200	sequence-specific DNA binding site [nucleotide binding]; other site
1215914003201	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
1215914003202	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
1215914003203	GcrA cell cycle regulator; Region: GcrA; cl11564
1215914003204	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1215914003205	Terminase small subunit; Region: Terminase_2; pfam03592
1215914003206	Phage terminase large subunit; Region: Terminase_3; cl12054
1215914003207	Terminase-like family; Region: Terminase_6; pfam03237
1215914003208	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
1215914003209	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
1215914003210	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
1215914003211	Domain of unknown function (DUF4355); Region: DUF4355; pfam14265
1215914003212	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
1215914003213	Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135
1215914003214	Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883
1215914003215	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
1215914003216	Phage major tail protein 2; Region: Phage_tail_2; pfam06199
1215914003217	Phage protein; Region: DUF3647; pfam12363
1215914003218	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
1215914003219	Phage-related protein [Function unknown]; Region: COG5412
1215914003220	Phage tail protein; Region: Sipho_tail; pfam05709
1215914003221	Phage tail protein; Region: Sipho_tail; cl17486
1215914003222	Phage tail protein; Region: Sipho_tail; cl17486
1215914003223	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
1215914003224	Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900
1215914003225	Bacteriophage holin; Region: Phage_holin_1; pfam04531
1215914003226	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
1215914003227	active site
1215914003228	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1215914003229	Bacterial SH3 domain; Region: SH3_5; pfam08460
1215914003230	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1215914003231	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1215914003232	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
1215914003233	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
1215914003234	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
1215914003235	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1215914003236	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930
1215914003237	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1215914003238	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1215914003239	Helix-turn-helix domain; Region: HTH_38; pfam13936
1215914003240	Integrase core domain; Region: rve; pfam00665
1215914003241	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1215914003242	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1215914003243	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1215914003244	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1215914003245	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1215914003246	nucleoside/Zn binding site; other site
1215914003247	dimer interface [polypeptide binding]; other site
1215914003248	catalytic motif [active]
1215914003249	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1215914003250	TspO/MBR family; Region: TspO_MBR; pfam03073
1215914003251	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914003252	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1215914003253	putative substrate translocation pore; other site
1215914003254	Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
1215914003255	Peptidase family C69; Region: Peptidase_C69; pfam03577
1215914003256	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1215914003257	catalytic core [active]
1215914003258	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1215914003259	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1215914003260	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1215914003261	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1215914003262	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1215914003263	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914003264	Walker A/P-loop; other site
1215914003265	ATP binding site [chemical binding]; other site
1215914003266	Q-loop/lid; other site
1215914003267	ABC transporter signature motif; other site
1215914003268	Walker B; other site
1215914003269	D-loop; other site
1215914003270	H-loop/switch region; other site
1215914003271	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1215914003272	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1215914003273	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1215914003274	Walker A/P-loop; other site
1215914003275	ATP binding site [chemical binding]; other site
1215914003276	Q-loop/lid; other site
1215914003277	ABC transporter signature motif; other site
1215914003278	Walker B; other site
1215914003279	D-loop; other site
1215914003280	H-loop/switch region; other site
1215914003281	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1215914003282	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1215914003283	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
1215914003284	putative metal binding site [ion binding]; other site
1215914003285	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1215914003286	active site
1215914003287	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1215914003288	Beta-lactamase; Region: Beta-lactamase; pfam00144
1215914003289	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1215914003290	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
1215914003291	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1215914003292	thymidine kinase; Provisional; Region: PRK04296
1215914003293	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1215914003294	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1215914003295	RF-1 domain; Region: RF-1; pfam00472
1215914003296	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1215914003297	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1215914003298	S-adenosylmethionine binding site [chemical binding]; other site
1215914003299	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1215914003300	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
1215914003301	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1215914003302	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1215914003303	dimer interface [polypeptide binding]; other site
1215914003304	active site
1215914003305	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1215914003306	folate binding site [chemical binding]; other site
1215914003307	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1215914003308	active site
1215914003309	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1215914003310	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1215914003311	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1215914003312	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1215914003313	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1215914003314	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1215914003315	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1215914003316	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1215914003317	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1215914003318	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1215914003319	beta subunit interaction interface [polypeptide binding]; other site
1215914003320	Walker A motif; other site
1215914003321	ATP binding site [chemical binding]; other site
1215914003322	Walker B motif; other site
1215914003323	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1215914003324	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1215914003325	core domain interface [polypeptide binding]; other site
1215914003326	delta subunit interface [polypeptide binding]; other site
1215914003327	epsilon subunit interface [polypeptide binding]; other site
1215914003328	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1215914003329	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1215914003330	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1215914003331	alpha subunit interaction interface [polypeptide binding]; other site
1215914003332	Walker A motif; other site
1215914003333	ATP binding site [chemical binding]; other site
1215914003334	Walker B motif; other site
1215914003335	inhibitor binding site; inhibition site
1215914003336	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1215914003337	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1215914003338	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1215914003339	gamma subunit interface [polypeptide binding]; other site
1215914003340	epsilon subunit interface [polypeptide binding]; other site
1215914003341	LBP interface [polypeptide binding]; other site
1215914003342	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
1215914003343	rod shape-determining protein MreB; Provisional; Region: PRK13930
1215914003344	MreB and similar proteins; Region: MreB_like; cd10225
1215914003345	nucleotide binding site [chemical binding]; other site
1215914003346	Mg binding site [ion binding]; other site
1215914003347	putative protofilament interaction site [polypeptide binding]; other site
1215914003348	RodZ interaction site [polypeptide binding]; other site
1215914003349	Haemolytic domain; Region: Haemolytic; cl00506
1215914003350	Protein of unknown function (DUF2969); Region: DUF2969; pfam11184
1215914003351	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1215914003352	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1215914003353	lipoyl attachment site [posttranslational modification]; other site
1215914003354	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
1215914003355	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
1215914003356	metal binding site [ion binding]; metal-binding site
1215914003357	dimer interface [polypeptide binding]; other site
1215914003358	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1215914003359	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1215914003360	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1215914003361	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1215914003362	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1215914003363	Walker A/P-loop; other site
1215914003364	ATP binding site [chemical binding]; other site
1215914003365	Q-loop/lid; other site
1215914003366	ABC transporter signature motif; other site
1215914003367	Walker B; other site
1215914003368	D-loop; other site
1215914003369	H-loop/switch region; other site
1215914003370	NIL domain; Region: NIL; pfam09383
1215914003371	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914003372	dimer interface [polypeptide binding]; other site
1215914003373	conserved gate region; other site
1215914003374	ABC-ATPase subunit interface; other site
1215914003375	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1215914003376	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1215914003377	Walker A/P-loop; other site
1215914003378	ATP binding site [chemical binding]; other site
1215914003379	Q-loop/lid; other site
1215914003380	ABC transporter signature motif; other site
1215914003381	Walker B; other site
1215914003382	D-loop; other site
1215914003383	H-loop/switch region; other site
1215914003384	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
1215914003385	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1215914003386	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1215914003387	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1215914003388	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1215914003389	catalytic residue [active]
1215914003390	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1215914003391	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1215914003392	trimerization site [polypeptide binding]; other site
1215914003393	active site
1215914003394	FeS assembly protein SufB; Region: sufB; TIGR01980
1215914003395	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1215914003396	Protein of unknown function (DUF1694); Region: DUF1694; pfam07997
1215914003397	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
1215914003398	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1215914003399	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1215914003400	motif II; other site
1215914003401	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1215914003402	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914003403	non-specific DNA binding site [nucleotide binding]; other site
1215914003404	salt bridge; other site
1215914003405	sequence-specific DNA binding site [nucleotide binding]; other site
1215914003406	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1215914003407	Ligand Binding Site [chemical binding]; other site
1215914003408	recombination factor protein RarA; Reviewed; Region: PRK13342
1215914003409	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1215914003410	Walker A motif; other site
1215914003411	ATP binding site [chemical binding]; other site
1215914003412	Walker B motif; other site
1215914003413	arginine finger; other site
1215914003414	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1215914003415	D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181
1215914003416	Protein of unknown function (DUF1694); Region: DUF1694; pfam07997
1215914003417	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
1215914003418	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
1215914003419	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
1215914003420	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1215914003421	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
1215914003422	putative L-serine binding site [chemical binding]; other site
1215914003423	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
1215914003424	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1215914003425	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1215914003426	catalytic core [active]
1215914003427	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1215914003428	short chain dehydrogenase; Provisional; Region: PRK06197
1215914003429	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
1215914003430	putative NAD(P) binding site [chemical binding]; other site
1215914003431	active site
1215914003432	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
1215914003433	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1215914003434	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1215914003435	active site
1215914003436	hypothetical protein; Provisional; Region: PRK07329
1215914003437	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1215914003438	active site
1215914003439	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1215914003440	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1215914003441	peptide binding site [polypeptide binding]; other site
1215914003442	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1215914003443	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1215914003444	dimer interface [polypeptide binding]; other site
1215914003445	phosphorylation site [posttranslational modification]
1215914003446	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1215914003447	ATP binding site [chemical binding]; other site
1215914003448	Mg2+ binding site [ion binding]; other site
1215914003449	G-X-G motif; other site
1215914003450	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1215914003451	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1215914003452	active site
1215914003453	phosphorylation site [posttranslational modification]
1215914003454	intermolecular recognition site; other site
1215914003455	dimerization interface [polypeptide binding]; other site
1215914003456	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1215914003457	DNA binding site [nucleotide binding]
1215914003458	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1215914003459	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914003460	Walker A/P-loop; other site
1215914003461	ATP binding site [chemical binding]; other site
1215914003462	Q-loop/lid; other site
1215914003463	ABC transporter signature motif; other site
1215914003464	Walker B; other site
1215914003465	D-loop; other site
1215914003466	H-loop/switch region; other site
1215914003467	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1215914003468	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1215914003469	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1215914003470	dimerization interface [polypeptide binding]; other site
1215914003471	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1215914003472	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1215914003473	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1215914003474	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1215914003475	NAD(P) binding site [chemical binding]; other site
1215914003476	active site
1215914003477	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1215914003478	dimerization interface [polypeptide binding]; other site
1215914003479	putative DNA binding site [nucleotide binding]; other site
1215914003480	putative Zn2+ binding site [ion binding]; other site
1215914003481	glutathionine S-transferase; Provisional; Region: PRK10542
1215914003482	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
1215914003483	C-terminal domain interface [polypeptide binding]; other site
1215914003484	GSH binding site (G-site) [chemical binding]; other site
1215914003485	dimer interface [polypeptide binding]; other site
1215914003486	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
1215914003487	dimer interface [polypeptide binding]; other site
1215914003488	substrate binding pocket (H-site) [chemical binding]; other site
1215914003489	N-terminal domain interface [polypeptide binding]; other site
1215914003490	SAP domain; Region: SAP; pfam02037
1215914003491	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1215914003492	Coenzyme A binding pocket [chemical binding]; other site
1215914003493	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1215914003494	Coenzyme A binding pocket [chemical binding]; other site
1215914003495	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1215914003496	Coenzyme A binding pocket [chemical binding]; other site
1215914003497	EDD domain protein, DegV family; Region: DegV; TIGR00762
1215914003498	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1215914003499	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1215914003500	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1215914003501	active site
1215914003502	phosphorylation site [posttranslational modification]
1215914003503	intermolecular recognition site; other site
1215914003504	dimerization interface [polypeptide binding]; other site
1215914003505	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1215914003506	DNA binding residues [nucleotide binding]
1215914003507	dimerization interface [polypeptide binding]; other site
1215914003508	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1215914003509	Histidine kinase; Region: HisKA_3; pfam07730
1215914003510	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1215914003511	ATP binding site [chemical binding]; other site
1215914003512	Mg2+ binding site [ion binding]; other site
1215914003513	G-X-G motif; other site
1215914003514	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1215914003515	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1215914003516	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1215914003517	Walker A/P-loop; other site
1215914003518	ATP binding site [chemical binding]; other site
1215914003519	Q-loop/lid; other site
1215914003520	ABC transporter signature motif; other site
1215914003521	Walker B; other site
1215914003522	D-loop; other site
1215914003523	H-loop/switch region; other site
1215914003524	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
1215914003525	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1215914003526	DNA binding residues [nucleotide binding]
1215914003527	dimer interface [polypeptide binding]; other site
1215914003528	Protein of unknown function (DUF2568); Region: DUF2568; pfam10823
1215914003529	Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664
1215914003530	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1215914003531	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1215914003532	Coenzyme A binding pocket [chemical binding]; other site
1215914003533	RelB antitoxin; Region: RelB; cl01171
1215914003534	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
1215914003535	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1215914003536	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1215914003537	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1215914003538	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1215914003539	RNA binding site [nucleotide binding]; other site
1215914003540	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1215914003541	Helix-turn-helix domain; Region: HTH_38; pfam13936
1215914003542	Integrase core domain; Region: rve; pfam00665
1215914003543	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1215914003544	Transposase domain (DUF772); Region: DUF772; pfam05598
1215914003545	HerA helicase [Replication, recombination, and repair]; Region: COG0433
1215914003546	SIR2-like domain; Region: SIR2_2; pfam13289
1215914003547	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1215914003548	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1215914003549	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1215914003550	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1215914003551	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1215914003552	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1215914003553	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1215914003554	RNA binding surface [nucleotide binding]; other site
1215914003555	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1215914003556	GAF domain; Region: GAF_2; pfam13185
1215914003557	septation ring formation regulator EzrA; Provisional; Region: PRK04778
1215914003558	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1215914003559	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1215914003560	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1215914003561	catalytic residue [active]
1215914003562	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
1215914003563	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1215914003564	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1215914003565	Ligand Binding Site [chemical binding]; other site
1215914003566	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
1215914003567	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1215914003568	CoA binding domain; Region: CoA_binding; pfam02629
1215914003569	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1215914003570	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1215914003571	active site
1215914003572	HIGH motif; other site
1215914003573	nucleotide binding site [chemical binding]; other site
1215914003574	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1215914003575	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1215914003576	active site
1215914003577	KMSKS motif; other site
1215914003578	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1215914003579	tRNA binding surface [nucleotide binding]; other site
1215914003580	anticodon binding site; other site
1215914003581	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1215914003582	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
1215914003583	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1215914003584	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
1215914003585	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1215914003586	motif II; other site
1215914003587	hypothetical protein; Reviewed; Region: PRK00024
1215914003588	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1215914003589	MPN+ (JAMM) motif; other site
1215914003590	Zinc-binding site [ion binding]; other site
1215914003591	rod shape-determining protein MreB; Provisional; Region: PRK13927
1215914003592	MreB and similar proteins; Region: MreB_like; cd10225
1215914003593	nucleotide binding site [chemical binding]; other site
1215914003594	Mg binding site [ion binding]; other site
1215914003595	putative protofilament interaction site [polypeptide binding]; other site
1215914003596	RodZ interaction site [polypeptide binding]; other site
1215914003597	rod shape-determining protein MreC; Provisional; Region: PRK13922
1215914003598	rod shape-determining protein MreC; Region: MreC; pfam04085
1215914003599	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
1215914003600	septum formation inhibitor; Reviewed; Region: minC; PRK00513
1215914003601	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
1215914003602	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
1215914003603	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
1215914003604	Switch I; other site
1215914003605	Switch II; other site
1215914003606	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914003607	dimer interface [polypeptide binding]; other site
1215914003608	conserved gate region; other site
1215914003609	putative PBP binding loops; other site
1215914003610	ABC-ATPase subunit interface; other site
1215914003611	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1215914003612	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914003613	Walker A/P-loop; other site
1215914003614	ATP binding site [chemical binding]; other site
1215914003615	Q-loop/lid; other site
1215914003616	ABC transporter signature motif; other site
1215914003617	Walker B; other site
1215914003618	D-loop; other site
1215914003619	H-loop/switch region; other site
1215914003620	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1215914003621	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1215914003622	substrate binding pocket [chemical binding]; other site
1215914003623	membrane-bound complex binding site; other site
1215914003624	hinge residues; other site
1215914003625	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1215914003626	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1215914003627	PLD-like domain; Region: PLDc_2; pfam13091
1215914003628	putative active site [active]
1215914003629	catalytic site [active]
1215914003630	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1215914003631	PLD-like domain; Region: PLDc_2; pfam13091
1215914003632	putative active site [active]
1215914003633	catalytic site [active]
1215914003634	cell division protein MraZ; Reviewed; Region: PRK00326
1215914003635	MraZ protein; Region: MraZ; pfam02381
1215914003636	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1215914003637	MraW methylase family; Region: Methyltransf_5; pfam01795
1215914003638	Cell division protein FtsL; Region: FtsL; cl11433
1215914003639	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1215914003640	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1215914003641	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1215914003642	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
1215914003643	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
1215914003644	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1215914003645	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1215914003646	Mg++ binding site [ion binding]; other site
1215914003647	putative catalytic motif [active]
1215914003648	putative substrate binding site [chemical binding]; other site
1215914003649	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
1215914003650	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
1215914003651	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1215914003652	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1215914003653	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1215914003654	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1215914003655	active site
1215914003656	homodimer interface [polypeptide binding]; other site
1215914003657	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1215914003658	Cell division protein FtsQ; Region: FtsQ; pfam03799
1215914003659	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
1215914003660	Cell division protein FtsA; Region: FtsA; smart00842
1215914003661	Cell division protein FtsA; Region: FtsA; pfam14450
1215914003662	cell division protein FtsZ; Validated; Region: PRK09330
1215914003663	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1215914003664	nucleotide binding site [chemical binding]; other site
1215914003665	SulA interaction site; other site
1215914003666	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
1215914003667	YGGT family; Region: YGGT; pfam02325
1215914003668	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
1215914003669	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1215914003670	RNA binding surface [nucleotide binding]; other site
1215914003671	DivIVA protein; Region: DivIVA; pfam05103
1215914003672	DivIVA domain; Region: DivI1A_domain; TIGR03544
1215914003673	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1215914003674	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1215914003675	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1215914003676	active site
1215914003677	HIGH motif; other site
1215914003678	nucleotide binding site [chemical binding]; other site
1215914003679	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1215914003680	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1215914003681	active site
1215914003682	KMSKS motif; other site
1215914003683	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1215914003684	tRNA binding surface [nucleotide binding]; other site
1215914003685	anticodon binding site; other site
1215914003686	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1215914003687	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1215914003688	DNA-binding site [nucleotide binding]; DNA binding site
1215914003689	RNA-binding motif; other site
1215914003690	PBP superfamily domain; Region: PBP_like_2; cl17296
1215914003691	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1215914003692	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1215914003693	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914003694	putative substrate translocation pore; other site
1215914003695	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914003696	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
1215914003697	5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112
1215914003698	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1215914003699	dimer interface [polypeptide binding]; other site
1215914003700	ADP-ribose binding site [chemical binding]; other site
1215914003701	active site
1215914003702	nudix motif; other site
1215914003703	metal binding site [ion binding]; metal-binding site
1215914003704	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1215914003705	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1215914003706	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1215914003707	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1215914003708	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1215914003709	catalytic residue [active]
1215914003710	Putative amino acid metabolism; Region: DUF1831; pfam08866
1215914003711	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914003712	Walker A/P-loop; other site
1215914003713	ATP binding site [chemical binding]; other site
1215914003714	Q-loop/lid; other site
1215914003715	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914003716	ABC transporter signature motif; other site
1215914003717	Walker B; other site
1215914003718	D-loop; other site
1215914003719	H-loop/switch region; other site
1215914003720	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914003721	AAA domain; Region: AAA_21; pfam13304
1215914003722	Walker A/P-loop; other site
1215914003723	ATP binding site [chemical binding]; other site
1215914003724	Q-loop/lid; other site
1215914003725	ABC transporter signature motif; other site
1215914003726	Walker B; other site
1215914003727	D-loop; other site
1215914003728	H-loop/switch region; other site
1215914003729	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1215914003730	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1215914003731	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1215914003732	catalytic core [active]
1215914003733	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
1215914003734	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
1215914003735	AAA domain; Region: AAA_30; pfam13604
1215914003736	Family description; Region: UvrD_C_2; pfam13538
1215914003737	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
1215914003738	Sterol carrier protein domain; Region: SCP2_2; pfam13530
1215914003739	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1215914003740	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1215914003741	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1215914003742	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1215914003743	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1215914003744	Protein of unknown function (DUF1447); Region: DUF1447; pfam07288
1215914003745	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1215914003746	active site
1215914003747	catalytic residues [active]
1215914003748	metal binding site [ion binding]; metal-binding site
1215914003749	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1215914003750	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1215914003751	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
1215914003752	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1215914003753	TPP-binding site [chemical binding]; other site
1215914003754	tetramer interface [polypeptide binding]; other site
1215914003755	heterodimer interface [polypeptide binding]; other site
1215914003756	phosphorylation loop region [posttranslational modification]
1215914003757	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1215914003758	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1215914003759	alpha subunit interface [polypeptide binding]; other site
1215914003760	TPP binding site [chemical binding]; other site
1215914003761	heterodimer interface [polypeptide binding]; other site
1215914003762	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1215914003763	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
1215914003764	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1215914003765	E3 interaction surface; other site
1215914003766	lipoyl attachment site [posttranslational modification]; other site
1215914003767	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1215914003768	E3 interaction surface; other site
1215914003769	lipoyl attachment site [posttranslational modification]; other site
1215914003770	e3 binding domain; Region: E3_binding; pfam02817
1215914003771	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1215914003772	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1215914003773	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1215914003774	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1215914003775	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1215914003776	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
1215914003777	NAD(P) binding site [chemical binding]; other site
1215914003778	substrate binding site [chemical binding]; other site
1215914003779	Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256
1215914003780	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1215914003781	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1215914003782	active site
1215914003783	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1215914003784	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1215914003785	G1 box; other site
1215914003786	putative GEF interaction site [polypeptide binding]; other site
1215914003787	GTP/Mg2+ binding site [chemical binding]; other site
1215914003788	Switch I region; other site
1215914003789	G2 box; other site
1215914003790	G3 box; other site
1215914003791	Switch II region; other site
1215914003792	G4 box; other site
1215914003793	G5 box; other site
1215914003794	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1215914003795	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1215914003796	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1215914003797	pyruvate carboxylase; Reviewed; Region: PRK12999
1215914003798	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1215914003799	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1215914003800	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1215914003801	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1215914003802	active site
1215914003803	catalytic residues [active]
1215914003804	metal binding site [ion binding]; metal-binding site
1215914003805	homodimer binding site [polypeptide binding]; other site
1215914003806	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1215914003807	carboxyltransferase (CT) interaction site; other site
1215914003808	biotinylation site [posttranslational modification]; other site
1215914003809	Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902
1215914003810	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1215914003811	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1215914003812	S-adenosylmethionine binding site [chemical binding]; other site
1215914003813	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1215914003814	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1215914003815	active site
1215914003816	(T/H)XGH motif; other site
1215914003817	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
1215914003818	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
1215914003819	protein binding site [polypeptide binding]; other site
1215914003820	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1215914003821	SLBB domain; Region: SLBB; pfam10531
1215914003822	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1215914003823	Helix-hairpin-helix motif; Region: HHH; pfam00633
1215914003824	Competence protein; Region: Competence; pfam03772
1215914003825	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
1215914003826	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1215914003827	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1215914003828	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1215914003829	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1215914003830	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1215914003831	16S/18S rRNA binding site [nucleotide binding]; other site
1215914003832	S13e-L30e interaction site [polypeptide binding]; other site
1215914003833	25S rRNA binding site [nucleotide binding]; other site
1215914003834	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1215914003835	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1215914003836	elongation factor Tu; Reviewed; Region: PRK00049
1215914003837	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1215914003838	G1 box; other site
1215914003839	GEF interaction site [polypeptide binding]; other site
1215914003840	GTP/Mg2+ binding site [chemical binding]; other site
1215914003841	Switch I region; other site
1215914003842	G2 box; other site
1215914003843	G3 box; other site
1215914003844	Switch II region; other site
1215914003845	G4 box; other site
1215914003846	G5 box; other site
1215914003847	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1215914003848	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1215914003849	Antibiotic Binding Site [chemical binding]; other site
1215914003850	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1215914003851	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1215914003852	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1215914003853	Walker A/P-loop; other site
1215914003854	ATP binding site [chemical binding]; other site
1215914003855	Q-loop/lid; other site
1215914003856	ABC transporter signature motif; other site
1215914003857	Walker B; other site
1215914003858	D-loop; other site
1215914003859	H-loop/switch region; other site
1215914003860	trigger factor; Provisional; Region: tig; PRK01490
1215914003861	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1215914003862	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1215914003863	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1215914003864	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1215914003865	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1215914003866	Walker A motif; other site
1215914003867	ATP binding site [chemical binding]; other site
1215914003868	Walker B motif; other site
1215914003869	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1215914003870	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
1215914003871	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1215914003872	G1 box; other site
1215914003873	GTP/Mg2+ binding site [chemical binding]; other site
1215914003874	Switch I region; other site
1215914003875	G2 box; other site
1215914003876	G3 box; other site
1215914003877	Switch II region; other site
1215914003878	G4 box; other site
1215914003879	G5 box; other site
1215914003880	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
1215914003881	putative metal binding site [ion binding]; other site
1215914003882	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1215914003883	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1215914003884	substrate binding pocket [chemical binding]; other site
1215914003885	membrane-bound complex binding site; other site
1215914003886	hinge residues; other site
1215914003887	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1215914003888	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914003889	dimer interface [polypeptide binding]; other site
1215914003890	conserved gate region; other site
1215914003891	putative PBP binding loops; other site
1215914003892	ABC-ATPase subunit interface; other site
1215914003893	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1215914003894	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1215914003895	Walker A/P-loop; other site
1215914003896	ATP binding site [chemical binding]; other site
1215914003897	Q-loop/lid; other site
1215914003898	ABC transporter signature motif; other site
1215914003899	Walker B; other site
1215914003900	D-loop; other site
1215914003901	H-loop/switch region; other site
1215914003902	Pleckstrin homology-like domain; Region: PH-like; cl17171
1215914003903	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1215914003904	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1215914003905	GIY-YIG motif/motif A; other site
1215914003906	active site
1215914003907	catalytic site [active]
1215914003908	putative DNA binding site [nucleotide binding]; other site
1215914003909	metal binding site [ion binding]; metal-binding site
1215914003910	UvrB/uvrC motif; Region: UVR; pfam02151
1215914003911	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1215914003912	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
1215914003913	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1215914003914	active site
1215914003915	phosphorylation site [posttranslational modification]
1215914003916	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1215914003917	active site
1215914003918	P-loop; other site
1215914003919	phosphorylation site [posttranslational modification]
1215914003920	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1215914003921	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1215914003922	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1215914003923	putative substrate binding site [chemical binding]; other site
1215914003924	putative ATP binding site [chemical binding]; other site
1215914003925	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1215914003926	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1215914003927	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1215914003928	GTPase CgtA; Reviewed; Region: obgE; PRK12297
1215914003929	GTP1/OBG; Region: GTP1_OBG; pfam01018
1215914003930	Obg GTPase; Region: Obg; cd01898
1215914003931	G1 box; other site
1215914003932	GTP/Mg2+ binding site [chemical binding]; other site
1215914003933	Switch I region; other site
1215914003934	G2 box; other site
1215914003935	G3 box; other site
1215914003936	Switch II region; other site
1215914003937	G4 box; other site
1215914003938	G5 box; other site
1215914003939	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1215914003940	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1215914003941	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1215914003942	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1215914003943	catalytic triad [active]
1215914003944	catalytic triad [active]
1215914003945	oxyanion hole [active]
1215914003946	ribonuclease Z; Region: RNase_Z; TIGR02651
1215914003947	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1215914003948	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1215914003949	NAD(P) binding site [chemical binding]; other site
1215914003950	active site
1215914003951	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
1215914003952	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1215914003953	Clp amino terminal domain; Region: Clp_N; pfam02861
1215914003954	Clp amino terminal domain; Region: Clp_N; pfam02861
1215914003955	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1215914003956	Walker A motif; other site
1215914003957	ATP binding site [chemical binding]; other site
1215914003958	Walker B motif; other site
1215914003959	arginine finger; other site
1215914003960	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1215914003961	Walker A motif; other site
1215914003962	ATP binding site [chemical binding]; other site
1215914003963	Walker B motif; other site
1215914003964	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1215914003965	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
1215914003966	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
1215914003967	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1215914003968	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1215914003969	active site
1215914003970	metal binding site [ion binding]; metal-binding site
1215914003971	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1215914003972	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
1215914003973	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
1215914003974	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
1215914003975	active site
1215914003976	PHP Thumb interface [polypeptide binding]; other site
1215914003977	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1215914003978	generic binding surface I; other site
1215914003979	generic binding surface II; other site
1215914003980	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
1215914003981	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1215914003982	active site
1215914003983	ADP/pyrophosphate binding site [chemical binding]; other site
1215914003984	dimerization interface [polypeptide binding]; other site
1215914003985	allosteric effector site; other site
1215914003986	fructose-1,6-bisphosphate binding site; other site
1215914003987	pyruvate kinase; Provisional; Region: PRK06354
1215914003988	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1215914003989	active site
1215914003990	domain interfaces; other site
1215914003991	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
1215914003992	Protein of unknown function (DUF441); Region: DUF441; pfam04284
1215914003993	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1215914003994	S1 domain; Region: S1_2; pfam13509
1215914003995	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1215914003996	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1215914003997	active site
1215914003998	Int/Topo IB signature motif; other site
1215914003999	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
1215914004000	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
1215914004001	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1215914004002	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1215914004003	RNA binding surface [nucleotide binding]; other site
1215914004004	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1215914004005	active site
1215914004006	Predicted membrane protein [Function unknown]; Region: COG3601
1215914004007	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1215914004008	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
1215914004009	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
1215914004010	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
1215914004011	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1215914004012	ATP binding site [chemical binding]; other site
1215914004013	putative Mg++ binding site [ion binding]; other site
1215914004014	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1215914004015	nucleotide binding region [chemical binding]; other site
1215914004016	ATP-binding site [chemical binding]; other site
1215914004017	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1215914004018	cytidylate kinase; Provisional; Region: cmk; PRK00023
1215914004019	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1215914004020	CMP-binding site; other site
1215914004021	The sites determining sugar specificity; other site
1215914004022	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
1215914004023	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1215914004024	RNA binding site [nucleotide binding]; other site
1215914004025	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1215914004026	RNA binding site [nucleotide binding]; other site
1215914004027	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1215914004028	RNA binding site [nucleotide binding]; other site
1215914004029	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1215914004030	RNA binding site [nucleotide binding]; other site
1215914004031	GTP-binding protein Der; Reviewed; Region: PRK00093
1215914004032	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1215914004033	G1 box; other site
1215914004034	GTP/Mg2+ binding site [chemical binding]; other site
1215914004035	Switch I region; other site
1215914004036	G2 box; other site
1215914004037	Switch II region; other site
1215914004038	G3 box; other site
1215914004039	G4 box; other site
1215914004040	G5 box; other site
1215914004041	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1215914004042	G1 box; other site
1215914004043	GTP/Mg2+ binding site [chemical binding]; other site
1215914004044	Switch I region; other site
1215914004045	G2 box; other site
1215914004046	G3 box; other site
1215914004047	Switch II region; other site
1215914004048	G4 box; other site
1215914004049	G5 box; other site
1215914004050	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1215914004051	IHF dimer interface [polypeptide binding]; other site
1215914004052	IHF - DNA interface [nucleotide binding]; other site
1215914004053	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1215914004054	TPR motif; other site
1215914004055	binding surface
1215914004056	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1215914004057	binding surface
1215914004058	TPR motif; other site
1215914004059	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1215914004060	binding surface
1215914004061	TPR motif; other site
1215914004062	TPR repeat; Region: TPR_11; pfam13414
1215914004063	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1215914004064	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1215914004065	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1215914004066	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1215914004067	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
1215914004068	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1215914004069	active site
1215914004070	NTP binding site [chemical binding]; other site
1215914004071	metal binding triad [ion binding]; metal-binding site
1215914004072	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1215914004073	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1215914004074	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1215914004075	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914004076	Walker A/P-loop; other site
1215914004077	ATP binding site [chemical binding]; other site
1215914004078	Q-loop/lid; other site
1215914004079	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1215914004080	ABC transporter signature motif; other site
1215914004081	Walker B; other site
1215914004082	D-loop; other site
1215914004083	ABC transporter; Region: ABC_tran_2; pfam12848
1215914004084	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1215914004085	thymidylate synthase; Region: thym_sym; TIGR03284
1215914004086	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1215914004087	dimerization interface [polypeptide binding]; other site
1215914004088	active site
1215914004089	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1215914004090	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1215914004091	folate binding site [chemical binding]; other site
1215914004092	NADP+ binding site [chemical binding]; other site
1215914004093	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1215914004094	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1215914004095	EDD domain protein, DegV family; Region: DegV; TIGR00762
1215914004096	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1215914004097	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
1215914004098	active site
1215914004099	catalytic triad [active]
1215914004100	oxyanion hole [active]
1215914004101	Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911
1215914004102	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
1215914004103	hypothetical protein; Provisional; Region: PRK13672
1215914004104	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1215914004105	C-terminal peptidase (prc); Region: prc; TIGR00225
1215914004106	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1215914004107	protein binding site [polypeptide binding]; other site
1215914004108	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1215914004109	Catalytic dyad [active]
1215914004110	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1215914004111	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1215914004112	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
1215914004113	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1215914004114	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914004115	sequence-specific DNA binding site [nucleotide binding]; other site
1215914004116	salt bridge; other site
1215914004117	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
1215914004118	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1215914004119	GTP/Mg2+ binding site [chemical binding]; other site
1215914004120	G4 box; other site
1215914004121	G5 box; other site
1215914004122	G1 box; other site
1215914004123	Switch I region; other site
1215914004124	G2 box; other site
1215914004125	G3 box; other site
1215914004126	Switch II region; other site
1215914004127	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1215914004128	RNA/DNA hybrid binding site [nucleotide binding]; other site
1215914004129	active site
1215914004130	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1215914004131	DNA protecting protein DprA; Region: dprA; TIGR00732
1215914004132	DNA topoisomerase I; Validated; Region: PRK05582
1215914004133	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1215914004134	active site
1215914004135	interdomain interaction site; other site
1215914004136	putative metal-binding site [ion binding]; other site
1215914004137	nucleotide binding site [chemical binding]; other site
1215914004138	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1215914004139	domain I; other site
1215914004140	DNA binding groove [nucleotide binding]
1215914004141	phosphate binding site [ion binding]; other site
1215914004142	domain II; other site
1215914004143	domain III; other site
1215914004144	nucleotide binding site [chemical binding]; other site
1215914004145	catalytic site [active]
1215914004146	domain IV; other site
1215914004147	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1215914004148	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1215914004149	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1215914004150	Glucose inhibited division protein A; Region: GIDA; pfam01134
1215914004151	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1215914004152	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1215914004153	active site
1215914004154	Int/Topo IB signature motif; other site
1215914004155	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1215914004156	active site
1215914004157	HslU subunit interaction site [polypeptide binding]; other site
1215914004158	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1215914004159	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1215914004160	Walker A motif; other site
1215914004161	ATP binding site [chemical binding]; other site
1215914004162	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1215914004163	Walker B motif; other site
1215914004164	arginine finger; other site
1215914004165	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1215914004166	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
1215914004167	active site
1215914004168	catalytic residues [active]
1215914004169	membrane protein; Provisional; Region: PRK14392
1215914004170	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
1215914004171	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1215914004172	Mg2+ binding site [ion binding]; other site
1215914004173	G-X-G motif; other site
1215914004174	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1215914004175	anchoring element; other site
1215914004176	dimer interface [polypeptide binding]; other site
1215914004177	ATP binding site [chemical binding]; other site
1215914004178	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1215914004179	active site
1215914004180	putative metal-binding site [ion binding]; other site
1215914004181	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1215914004182	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1215914004183	CAP-like domain; other site
1215914004184	active site
1215914004185	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
1215914004186	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
1215914004187	primary dimer interface [polypeptide binding]; other site
1215914004188	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1215914004189	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1215914004190	Pyruvate formate lyase 1; Region: PFL1; cd01678
1215914004191	coenzyme A binding site [chemical binding]; other site
1215914004192	active site
1215914004193	catalytic residues [active]
1215914004194	glycine loop; other site
1215914004195	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
1215914004196	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1215914004197	FeS/SAM binding site; other site
1215914004198	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1215914004199	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1215914004200	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1215914004201	dimerization interface [polypeptide binding]; other site
1215914004202	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
1215914004203	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1215914004204	DHHA2 domain; Region: DHHA2; pfam02833
1215914004205	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
1215914004206	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1215914004207	active site
1215914004208	DNA binding site [nucleotide binding]
1215914004209	Int/Topo IB signature motif; other site
1215914004210	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1215914004211	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1215914004212	ATP binding site [chemical binding]; other site
1215914004213	Mg2+ binding site [ion binding]; other site
1215914004214	G-X-G motif; other site
1215914004215	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1215914004216	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1215914004217	active site
1215914004218	phosphorylation site [posttranslational modification]
1215914004219	intermolecular recognition site; other site
1215914004220	dimerization interface [polypeptide binding]; other site
1215914004221	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1215914004222	DNA binding site [nucleotide binding]
1215914004223	H+ Antiporter protein; Region: 2A0121; TIGR00900
1215914004224	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914004225	putative substrate translocation pore; other site
1215914004226	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1215914004227	Coenzyme A binding pocket [chemical binding]; other site
1215914004228	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1215914004229	dimer interface [polypeptide binding]; other site
1215914004230	FMN binding site [chemical binding]; other site
1215914004231	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
1215914004232	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1215914004233	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1215914004234	homodimer interface [polypeptide binding]; other site
1215914004235	catalytic residue [active]
1215914004236	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1215914004237	metal binding site [ion binding]; metal-binding site
1215914004238	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1215914004239	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1215914004240	substrate binding site [chemical binding]; other site
1215914004241	glutamase interaction surface [polypeptide binding]; other site
1215914004242	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1215914004243	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
1215914004244	catalytic residues [active]
1215914004245	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
1215914004246	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1215914004247	putative active site [active]
1215914004248	oxyanion strand; other site
1215914004249	catalytic triad [active]
1215914004250	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1215914004251	4-fold oligomerization interface [polypeptide binding]; other site
1215914004252	putative active site pocket [active]
1215914004253	metal binding residues [ion binding]; metal-binding site
1215914004254	3-fold/trimer interface [polypeptide binding]; other site
1215914004255	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1215914004256	histidinol dehydrogenase; Region: hisD; TIGR00069
1215914004257	NAD binding site [chemical binding]; other site
1215914004258	dimerization interface [polypeptide binding]; other site
1215914004259	product binding site; other site
1215914004260	substrate binding site [chemical binding]; other site
1215914004261	zinc binding site [ion binding]; other site
1215914004262	catalytic residues [active]
1215914004263	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
1215914004264	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
1215914004265	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
1215914004266	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1215914004267	dimer interface [polypeptide binding]; other site
1215914004268	motif 1; other site
1215914004269	active site
1215914004270	motif 2; other site
1215914004271	motif 3; other site
1215914004272	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
1215914004273	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1215914004274	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1215914004275	homodimer interface [polypeptide binding]; other site
1215914004276	catalytic residue [active]
1215914004277	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
1215914004278	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1215914004279	dimer interface [polypeptide binding]; other site
1215914004280	ADP-ribose binding site [chemical binding]; other site
1215914004281	active site
1215914004282	nudix motif; other site
1215914004283	metal binding site [ion binding]; metal-binding site
1215914004284	EDD domain protein, DegV family; Region: DegV; TIGR00762
1215914004285	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1215914004286	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
1215914004287	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1215914004288	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Sulfolobus solfataricus (Ss) and its homologs from archaea and bacteria; Region: NTP-PPase_SsMazG; cd11535
1215914004289	metal binding site [ion binding]; metal-binding site
1215914004290	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1215914004291	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1215914004292	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1215914004293	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1215914004294	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1215914004295	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1215914004296	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1215914004297	E3 interaction surface; other site
1215914004298	lipoyl attachment site [posttranslational modification]; other site
1215914004299	e3 binding domain; Region: E3_binding; pfam02817
1215914004300	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1215914004301	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1215914004302	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1215914004303	alpha subunit interface [polypeptide binding]; other site
1215914004304	TPP binding site [chemical binding]; other site
1215914004305	heterodimer interface [polypeptide binding]; other site
1215914004306	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1215914004307	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
1215914004308	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1215914004309	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1215914004310	butyrate kinase; Provisional; Region: PRK03011
1215914004311	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
1215914004312	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1215914004313	active site
1215914004314	dimer interface [polypeptide binding]; other site
1215914004315	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
1215914004316	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
1215914004317	heterodimer interface [polypeptide binding]; other site
1215914004318	active site
1215914004319	FMN binding site [chemical binding]; other site
1215914004320	homodimer interface [polypeptide binding]; other site
1215914004321	substrate binding site [chemical binding]; other site
1215914004322	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1215914004323	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1215914004324	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1215914004325	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1215914004326	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1215914004327	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1215914004328	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1215914004329	IMP binding site; other site
1215914004330	dimer interface [polypeptide binding]; other site
1215914004331	interdomain contacts; other site
1215914004332	partial ornithine binding site; other site
1215914004333	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1215914004334	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1215914004335	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1215914004336	catalytic site [active]
1215914004337	subunit interface [polypeptide binding]; other site
1215914004338	dihydroorotase; Validated; Region: pyrC; PRK09357
1215914004339	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1215914004340	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1215914004341	active site
1215914004342	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1215914004343	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1215914004344	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1215914004345	uracil transporter; Provisional; Region: PRK10720
1215914004346	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1215914004347	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1215914004348	RNA binding surface [nucleotide binding]; other site
1215914004349	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1215914004350	active site
1215914004351	lipoprotein signal peptidase; Provisional; Region: PRK14797
1215914004352	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
1215914004353	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1215914004354	Potassium binding sites [ion binding]; other site
1215914004355	Cesium cation binding sites [ion binding]; other site
1215914004356	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
1215914004357	RNA/DNA hybrid binding site [nucleotide binding]; other site
1215914004358	active site
1215914004359	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
1215914004360	dimer interface [polypeptide binding]; other site
1215914004361	FMN binding site [chemical binding]; other site
1215914004362	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
1215914004363	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1215914004364	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1215914004365	putative active site [active]
1215914004366	catalytic site [active]
1215914004367	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1215914004368	putative active site [active]
1215914004369	catalytic site [active]
1215914004370	Mga helix-turn-helix domain; Region: Mga; pfam05043
1215914004371	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1215914004372	catalytic residues [active]
1215914004373	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
1215914004374	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1215914004375	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1215914004376	active site
1215914004377	dimer interface [polypeptide binding]; other site
1215914004378	catalytic residues [active]
1215914004379	effector binding site; other site
1215914004380	R2 peptide binding site; other site
1215914004381	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1215914004382	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1215914004383	dimer interface [polypeptide binding]; other site
1215914004384	putative radical transfer pathway; other site
1215914004385	diiron center [ion binding]; other site
1215914004386	tyrosyl radical; other site
1215914004387	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1215914004388	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1215914004389	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1215914004390	dimerization interface [polypeptide binding]; other site
1215914004391	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
1215914004392	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
1215914004393	active site
1215914004394	Zn binding site [ion binding]; other site
1215914004395	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1215914004396	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1215914004397	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1215914004398	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1215914004399	Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155
1215914004400	putative ligand binding site [chemical binding]; other site
1215914004401	NAD binding site [chemical binding]; other site
1215914004402	catalytic site [active]
1215914004403	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
1215914004404	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1215914004405	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1215914004406	cell division protein GpsB; Provisional; Region: PRK14127
1215914004407	DivIVA domain; Region: DivI1A_domain; TIGR03544
1215914004408	hypothetical protein; Provisional; Region: PRK13660
1215914004409	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
1215914004410	Transglycosylase; Region: Transgly; pfam00912
1215914004411	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1215914004412	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1215914004413	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
1215914004414	catalytic motif [active]
1215914004415	Zn binding site [ion binding]; other site
1215914004416	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1215914004417	endonuclease III; Region: ENDO3c; smart00478
1215914004418	minor groove reading motif; other site
1215914004419	helix-hairpin-helix signature motif; other site
1215914004420	substrate binding pocket [chemical binding]; other site
1215914004421	active site
1215914004422	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
1215914004423	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1215914004424	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1215914004425	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
1215914004426	putative dimer interface [polypeptide binding]; other site
1215914004427	putative anticodon binding site; other site
1215914004428	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1215914004429	homodimer interface [polypeptide binding]; other site
1215914004430	motif 1; other site
1215914004431	motif 2; other site
1215914004432	active site
1215914004433	motif 3; other site
1215914004434	aspartate aminotransferase; Provisional; Region: PRK05764
1215914004435	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1215914004436	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1215914004437	homodimer interface [polypeptide binding]; other site
1215914004438	catalytic residue [active]
1215914004439	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
1215914004440	DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407
1215914004441	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1215914004442	active site
1215914004443	catalytic site [active]
1215914004444	substrate binding site [chemical binding]; other site
1215914004445	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1215914004446	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
1215914004447	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1215914004448	ATP binding site [chemical binding]; other site
1215914004449	Family description; Region: UvrD_C_2; pfam13538
1215914004450	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1215914004451	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
1215914004452	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1215914004453	mevalonate kinase; Region: mevalon_kin; TIGR00549
1215914004454	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1215914004455	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1215914004456	diphosphomevalonate decarboxylase; Region: PLN02407
1215914004457	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
1215914004458	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
1215914004459	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
1215914004460	homotetramer interface [polypeptide binding]; other site
1215914004461	FMN binding site [chemical binding]; other site
1215914004462	homodimer contacts [polypeptide binding]; other site
1215914004463	putative active site [active]
1215914004464	putative substrate binding site [chemical binding]; other site
1215914004465	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
1215914004466	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1215914004467	S-adenosylmethionine binding site [chemical binding]; other site
1215914004468	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
1215914004469	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1215914004470	4-oxalocrotonate tautomerase; Provisional; Region: PRK02220
1215914004471	active site 1 [active]
1215914004472	dimer interface [polypeptide binding]; other site
1215914004473	hexamer interface [polypeptide binding]; other site
1215914004474	active site 2 [active]
1215914004475	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1215914004476	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1215914004477	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
1215914004478	Family of unknown function (DUF633); Region: DUF633; pfam04816
1215914004479	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
1215914004480	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1215914004481	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1215914004482	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1215914004483	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1215914004484	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1215914004485	DNA binding residues [nucleotide binding]
1215914004486	DNA primase; Validated; Region: dnaG; PRK05667
1215914004487	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1215914004488	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1215914004489	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1215914004490	active site
1215914004491	metal binding site [ion binding]; metal-binding site
1215914004492	interdomain interaction site; other site
1215914004493	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1215914004494	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1215914004495	Recombination protein O N terminal; Region: RecO_N; pfam11967
1215914004496	DNA repair protein RecO; Region: reco; TIGR00613
1215914004497	Recombination protein O C terminal; Region: RecO_C; pfam02565
1215914004498	GTPase Era; Reviewed; Region: era; PRK00089
1215914004499	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1215914004500	G1 box; other site
1215914004501	GTP/Mg2+ binding site [chemical binding]; other site
1215914004502	Switch I region; other site
1215914004503	G2 box; other site
1215914004504	Switch II region; other site
1215914004505	G3 box; other site
1215914004506	G4 box; other site
1215914004507	G5 box; other site
1215914004508	KH domain; Region: KH_2; pfam07650
1215914004509	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1215914004510	active site
1215914004511	catalytic motif [active]
1215914004512	Zn binding site [ion binding]; other site
1215914004513	metal-binding heat shock protein; Provisional; Region: PRK00016
1215914004514	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1215914004515	PhoH-like protein; Region: PhoH; pfam02562
1215914004516	Yqey-like protein; Region: YqeY; pfam09424
1215914004517	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1215914004518	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
1215914004519	endonuclease IV; Provisional; Region: PRK01060
1215914004520	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1215914004521	AP (apurinic/apyrimidinic) site pocket; other site
1215914004522	DNA interaction; other site
1215914004523	Metal-binding active site; metal-binding site
1215914004524	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1215914004525	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1215914004526	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1215914004527	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1215914004528	SelR domain; Region: SelR; pfam01641
1215914004529	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1215914004530	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1215914004531	dimer interface [polypeptide binding]; other site
1215914004532	anticodon binding site; other site
1215914004533	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1215914004534	homodimer interface [polypeptide binding]; other site
1215914004535	motif 1; other site
1215914004536	active site
1215914004537	motif 2; other site
1215914004538	GAD domain; Region: GAD; pfam02938
1215914004539	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1215914004540	motif 3; other site
1215914004541	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1215914004542	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1215914004543	dimer interface [polypeptide binding]; other site
1215914004544	motif 1; other site
1215914004545	active site
1215914004546	motif 2; other site
1215914004547	motif 3; other site
1215914004548	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1215914004549	anticodon binding site; other site
1215914004550	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217
1215914004551	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1215914004552	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1215914004553	putative NAD(P) binding site [chemical binding]; other site
1215914004554	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1215914004555	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914004556	non-specific DNA binding site [nucleotide binding]; other site
1215914004557	salt bridge; other site
1215914004558	sequence-specific DNA binding site [nucleotide binding]; other site
1215914004559	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1215914004560	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
1215914004561	Walker A/P-loop; other site
1215914004562	ATP binding site [chemical binding]; other site
1215914004563	Q-loop/lid; other site
1215914004564	ABC transporter signature motif; other site
1215914004565	Walker B; other site
1215914004566	D-loop; other site
1215914004567	H-loop/switch region; other site
1215914004568	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
1215914004569	Bacterial SH3 domain; Region: SH3_3; pfam08239
1215914004570	Bacterial SH3 domain; Region: SH3_3; pfam08239
1215914004571	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1215914004572	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1215914004573	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1215914004574	active site
1215914004575	metal binding site [ion binding]; metal-binding site
1215914004576	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1215914004577	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1215914004578	motif II; other site
1215914004579	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1215914004580	putative active site [active]
1215914004581	dimerization interface [polypeptide binding]; other site
1215914004582	putative tRNAtyr binding site [nucleotide binding]; other site
1215914004583	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1215914004584	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1215914004585	Zn2+ binding site [ion binding]; other site
1215914004586	Mg2+ binding site [ion binding]; other site
1215914004587	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1215914004588	synthetase active site [active]
1215914004589	NTP binding site [chemical binding]; other site
1215914004590	metal binding site [ion binding]; metal-binding site
1215914004591	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1215914004592	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1215914004593	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1215914004594	RNA methyltransferase, RsmE family; Region: TIGR00046
1215914004595	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
1215914004596	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1215914004597	S-adenosylmethionine binding site [chemical binding]; other site
1215914004598	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1215914004599	active site
1215914004600	DNA binding site [nucleotide binding]
1215914004601	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
1215914004602	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1215914004603	Coenzyme A binding pocket [chemical binding]; other site
1215914004604	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1215914004605	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1215914004606	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1215914004607	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1215914004608	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
1215914004609	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
1215914004610	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1215914004611	putative deacylase active site [active]
1215914004612	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1215914004613	active site
1215914004614	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1215914004615	DHH family; Region: DHH; pfam01368
1215914004616	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538
1215914004617	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
1215914004618	GTP-binding protein LepA; Provisional; Region: PRK05433
1215914004619	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1215914004620	G1 box; other site
1215914004621	putative GEF interaction site [polypeptide binding]; other site
1215914004622	GTP/Mg2+ binding site [chemical binding]; other site
1215914004623	Switch I region; other site
1215914004624	G2 box; other site
1215914004625	G3 box; other site
1215914004626	Switch II region; other site
1215914004627	G4 box; other site
1215914004628	G5 box; other site
1215914004629	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1215914004630	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1215914004631	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1215914004632	chaperone protein DnaJ; Provisional; Region: PRK14276
1215914004633	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1215914004634	HSP70 interaction site [polypeptide binding]; other site
1215914004635	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1215914004636	substrate binding site [polypeptide binding]; other site
1215914004637	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1215914004638	Zn binding sites [ion binding]; other site
1215914004639	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1215914004640	dimer interface [polypeptide binding]; other site
1215914004641	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1215914004642	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1215914004643	nucleotide binding site [chemical binding]; other site
1215914004644	NEF interaction site [polypeptide binding]; other site
1215914004645	SBD interface [polypeptide binding]; other site
1215914004646	GrpE; Region: GrpE; pfam01025
1215914004647	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1215914004648	dimer interface [polypeptide binding]; other site
1215914004649	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1215914004650	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1215914004651	HTH domain; Region: HTH_11; pfam08279
1215914004652	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1215914004653	HemN C-terminal domain; Region: HemN_C; pfam06969
1215914004654	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
1215914004655	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1215914004656	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1215914004657	active site
1215914004658	Riboflavin kinase; Region: Flavokinase; smart00904
1215914004659	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484
1215914004660	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1215914004661	RNA binding site [nucleotide binding]; other site
1215914004662	active site
1215914004663	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
1215914004664	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1215914004665	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1215914004666	translation initiation factor IF-2; Region: IF-2; TIGR00487
1215914004667	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1215914004668	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1215914004669	G1 box; other site
1215914004670	putative GEF interaction site [polypeptide binding]; other site
1215914004671	GTP/Mg2+ binding site [chemical binding]; other site
1215914004672	Switch I region; other site
1215914004673	G2 box; other site
1215914004674	G3 box; other site
1215914004675	Switch II region; other site
1215914004676	G4 box; other site
1215914004677	G5 box; other site
1215914004678	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1215914004679	Translation-initiation factor 2; Region: IF-2; pfam11987
1215914004680	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1215914004681	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
1215914004682	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
1215914004683	putative RNA binding cleft [nucleotide binding]; other site
1215914004684	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1215914004685	NusA N-terminal domain; Region: NusA_N; pfam08529
1215914004686	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1215914004687	RNA binding site [nucleotide binding]; other site
1215914004688	homodimer interface [polypeptide binding]; other site
1215914004689	NusA-like KH domain; Region: KH_5; pfam13184
1215914004690	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1215914004691	G-X-X-G motif; other site
1215914004692	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1215914004693	Sm and related proteins; Region: Sm_like; cl00259
1215914004694	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1215914004695	putative oligomer interface [polypeptide binding]; other site
1215914004696	putative RNA binding site [nucleotide binding]; other site
1215914004697	DNA polymerase III PolC; Validated; Region: polC; PRK00448
1215914004698	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
1215914004699	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
1215914004700	generic binding surface II; other site
1215914004701	generic binding surface I; other site
1215914004702	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1215914004703	active site
1215914004704	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1215914004705	active site
1215914004706	catalytic site [active]
1215914004707	substrate binding site [chemical binding]; other site
1215914004708	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
1215914004709	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1215914004710	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1215914004711	dimer interface [polypeptide binding]; other site
1215914004712	motif 1; other site
1215914004713	active site
1215914004714	motif 2; other site
1215914004715	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1215914004716	putative deacylase active site [active]
1215914004717	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1215914004718	active site
1215914004719	motif 3; other site
1215914004720	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1215914004721	anticodon binding site; other site
1215914004722	RIP metalloprotease RseP; Region: TIGR00054
1215914004723	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1215914004724	active site
1215914004725	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1215914004726	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1215914004727	protein binding site [polypeptide binding]; other site
1215914004728	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1215914004729	putative substrate binding region [chemical binding]; other site
1215914004730	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1215914004731	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1215914004732	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830
1215914004733	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1215914004734	catalytic residue [active]
1215914004735	putative FPP diphosphate  binding site; other site
1215914004736	putative FPP binding hydrophobic cleft; other site
1215914004737	dimer interface [polypeptide binding]; other site
1215914004738	putative IPP diphosphate binding site; other site
1215914004739	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1215914004740	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1215914004741	hinge region; other site
1215914004742	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1215914004743	putative nucleotide binding site [chemical binding]; other site
1215914004744	uridine monophosphate binding site [chemical binding]; other site
1215914004745	homohexameric interface [polypeptide binding]; other site
1215914004746	elongation factor Ts; Provisional; Region: tsf; PRK09377
1215914004747	UBA/TS-N domain; Region: UBA; pfam00627
1215914004748	Elongation factor TS; Region: EF_TS; pfam00889
1215914004749	Elongation factor TS; Region: EF_TS; pfam00889
1215914004750	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1215914004751	rRNA interaction site [nucleotide binding]; other site
1215914004752	S8 interaction site; other site
1215914004753	putative laminin-1 binding site; other site
1215914004754	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1215914004755	GIY-YIG motif/motif A; other site
1215914004756	putative active site [active]
1215914004757	putative metal binding site [ion binding]; other site
1215914004758	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1215914004759	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1215914004760	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1215914004761	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1215914004762	putative acyl-acceptor binding pocket; other site
1215914004763	amino acid transporter; Region: 2A0306; TIGR00909
1215914004764	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1215914004765	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1215914004766	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1215914004767	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1215914004768	Walker A/P-loop; other site
1215914004769	ATP binding site [chemical binding]; other site
1215914004770	Q-loop/lid; other site
1215914004771	ABC transporter signature motif; other site
1215914004772	Walker B; other site
1215914004773	D-loop; other site
1215914004774	H-loop/switch region; other site
1215914004775	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
1215914004776	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
1215914004777	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1215914004778	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1215914004779	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1215914004780	RimM N-terminal domain; Region: RimM; pfam01782
1215914004781	PRC-barrel domain; Region: PRC; pfam05239
1215914004782	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
1215914004783	KH domain; Region: KH_4; pfam13083
1215914004784	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1215914004785	signal recognition particle protein; Provisional; Region: PRK10867
1215914004786	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1215914004787	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1215914004788	P loop; other site
1215914004789	GTP binding site [chemical binding]; other site
1215914004790	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1215914004791	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
1215914004792	putative DNA-binding protein; Validated; Region: PRK00118
1215914004793	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1215914004794	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1215914004795	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1215914004796	P loop; other site
1215914004797	GTP binding site [chemical binding]; other site
1215914004798	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1215914004799	AAA domain; Region: AAA_23; pfam13476
1215914004800	Walker A/P-loop; other site
1215914004801	ATP binding site [chemical binding]; other site
1215914004802	Q-loop/lid; other site
1215914004803	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1215914004804	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1215914004805	ABC transporter signature motif; other site
1215914004806	Walker B; other site
1215914004807	D-loop; other site
1215914004808	H-loop/switch region; other site
1215914004809	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
1215914004810	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1215914004811	dimerization interface [polypeptide binding]; other site
1215914004812	active site
1215914004813	metal binding site [ion binding]; metal-binding site
1215914004814	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1215914004815	The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510
1215914004816	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1215914004817	peptide binding site [polypeptide binding]; other site
1215914004818	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1215914004819	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1215914004820	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914004821	dimer interface [polypeptide binding]; other site
1215914004822	conserved gate region; other site
1215914004823	putative PBP binding loops; other site
1215914004824	ABC-ATPase subunit interface; other site
1215914004825	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1215914004826	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914004827	dimer interface [polypeptide binding]; other site
1215914004828	conserved gate region; other site
1215914004829	putative PBP binding loops; other site
1215914004830	ABC-ATPase subunit interface; other site
1215914004831	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1215914004832	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1215914004833	Walker A/P-loop; other site
1215914004834	ATP binding site [chemical binding]; other site
1215914004835	Q-loop/lid; other site
1215914004836	ABC transporter signature motif; other site
1215914004837	Walker B; other site
1215914004838	D-loop; other site
1215914004839	H-loop/switch region; other site
1215914004840	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1215914004841	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1215914004842	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1215914004843	Walker A/P-loop; other site
1215914004844	ATP binding site [chemical binding]; other site
1215914004845	Q-loop/lid; other site
1215914004846	ABC transporter signature motif; other site
1215914004847	Walker B; other site
1215914004848	D-loop; other site
1215914004849	H-loop/switch region; other site
1215914004850	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1215914004851	acyl carrier protein; Provisional; Region: acpP; PRK00982
1215914004852	putative phosphate acyltransferase; Provisional; Region: PRK05331
1215914004853	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1215914004854	Y-family of DNA polymerases; Region: PolY; cl12025
1215914004855	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1215914004856	generic binding surface II; other site
1215914004857	ssDNA binding site; other site
1215914004858	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1215914004859	ATP binding site [chemical binding]; other site
1215914004860	putative Mg++ binding site [ion binding]; other site
1215914004861	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1215914004862	nucleotide binding region [chemical binding]; other site
1215914004863	ATP-binding site [chemical binding]; other site
1215914004864	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
1215914004865	DAK2 domain; Region: Dak2; pfam02734
1215914004866	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1215914004867	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1215914004868	Thiamine pyrophosphokinase; Region: TPK; cd07995
1215914004869	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
1215914004870	active site
1215914004871	dimerization interface [polypeptide binding]; other site
1215914004872	thiamine binding site [chemical binding]; other site
1215914004873	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1215914004874	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1215914004875	substrate binding site [chemical binding]; other site
1215914004876	hexamer interface [polypeptide binding]; other site
1215914004877	metal binding site [ion binding]; metal-binding site
1215914004878	GTPase RsgA; Reviewed; Region: PRK00098
1215914004879	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
1215914004880	RNA binding site [nucleotide binding]; other site
1215914004881	homodimer interface [polypeptide binding]; other site
1215914004882	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1215914004883	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1215914004884	GTP/Mg2+ binding site [chemical binding]; other site
1215914004885	G4 box; other site
1215914004886	G5 box; other site
1215914004887	G1 box; other site
1215914004888	Switch I region; other site
1215914004889	G2 box; other site
1215914004890	G3 box; other site
1215914004891	Switch II region; other site
1215914004892	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1215914004893	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1215914004894	active site
1215914004895	ATP binding site [chemical binding]; other site
1215914004896	substrate binding site [chemical binding]; other site
1215914004897	activation loop (A-loop); other site
1215914004898	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1215914004899	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1215914004900	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1215914004901	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1215914004902	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1215914004903	active site
1215914004904	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
1215914004905	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1215914004906	S-adenosylmethionine binding site [chemical binding]; other site
1215914004907	NusB family; Region: NusB; pfam01029
1215914004908	putative RNA binding site [nucleotide binding]; other site
1215914004909	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1215914004910	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1215914004911	substrate binding site [chemical binding]; other site
1215914004912	putative active site [active]
1215914004913	putative cosubstrate binding site; other site
1215914004914	catalytic site [active]
1215914004915	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1215914004916	substrate binding site [chemical binding]; other site
1215914004917	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
1215914004918	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1215914004919	ATP binding site [chemical binding]; other site
1215914004920	putative Mg++ binding site [ion binding]; other site
1215914004921	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1215914004922	nucleotide binding region [chemical binding]; other site
1215914004923	ATP-binding site [chemical binding]; other site
1215914004924	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1215914004925	phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313
1215914004926	Flavoprotein; Region: Flavoprotein; pfam02441
1215914004927	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1215914004928	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1215914004929	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1215914004930	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1215914004931	catalytic site [active]
1215914004932	G-X2-G-X-G-K; other site
1215914004933	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1215914004934	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1215914004935	nucleophile elbow; other site
1215914004936	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1215914004937	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1215914004938	Walker A/P-loop; other site
1215914004939	ATP binding site [chemical binding]; other site
1215914004940	Q-loop/lid; other site
1215914004941	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1215914004942	ABC transporter signature motif; other site
1215914004943	Walker B; other site
1215914004944	D-loop; other site
1215914004945	H-loop/switch region; other site
1215914004946	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1215914004947	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1215914004948	RNA binding surface [nucleotide binding]; other site
1215914004949	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1215914004950	S-adenosylmethionine binding site [chemical binding]; other site
1215914004951	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1215914004952	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1215914004953	substrate binding pocket [chemical binding]; other site
1215914004954	chain length determination region; other site
1215914004955	substrate-Mg2+ binding site; other site
1215914004956	catalytic residues [active]
1215914004957	aspartate-rich region 1; other site
1215914004958	active site lid residues [active]
1215914004959	aspartate-rich region 2; other site
1215914004960	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1215914004961	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1215914004962	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1215914004963	generic binding surface II; other site
1215914004964	generic binding surface I; other site
1215914004965	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14169
1215914004966	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1215914004967	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1215914004968	homodimer interface [polypeptide binding]; other site
1215914004969	NADP binding site [chemical binding]; other site
1215914004970	substrate binding site [chemical binding]; other site
1215914004971	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1215914004972	putative RNA binding site [nucleotide binding]; other site
1215914004973	Asp23 family; Region: Asp23; pfam03780
1215914004974	elongation factor P; Validated; Region: PRK00529
1215914004975	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1215914004976	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1215914004977	RNA binding site [nucleotide binding]; other site
1215914004978	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1215914004979	RNA binding site [nucleotide binding]; other site
1215914004980	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1215914004981	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1215914004982	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1215914004983	active site
1215914004984	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1215914004985	Protein of unknown function (DUF464); Region: DUF464; pfam04327
1215914004986	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1215914004987	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
1215914004988	X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168
1215914004989	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
1215914004990	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1215914004991	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1215914004992	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1215914004993	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1215914004994	DNA binding residues [nucleotide binding]
1215914004995	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1215914004996	putative dimer interface [polypeptide binding]; other site
1215914004997	Orn/Lys/Arg decarboxylase, major domain; Region: OKR_DC_1; pfam01276
1215914004998	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1215914004999	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1215914005000	catalytic residue [active]
1215914005001	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1215914005002	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
1215914005003	Aluminium resistance protein; Region: Alum_res; pfam06838
1215914005004	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1215914005005	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1215914005006	Protein of unknown function (DUF3042); Region: DUF3042; pfam11240
1215914005007	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1215914005008	active site residue [active]
1215914005009	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1215914005010	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1215914005011	nucleotide binding site [chemical binding]; other site
1215914005012	Rhomboid family; Region: Rhomboid; pfam01694
1215914005013	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1215914005014	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1215914005015	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1215914005016	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
1215914005017	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1215914005018	Helix-turn-helix domain; Region: HTH_38; pfam13936
1215914005019	Integrase core domain; Region: rve; pfam00665
1215914005020	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
1215914005021	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
1215914005022	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1215914005023	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1215914005024	active site
1215914005025	phosphorylation site [posttranslational modification]
1215914005026	intermolecular recognition site; other site
1215914005027	dimerization interface [polypeptide binding]; other site
1215914005028	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1215914005029	DNA binding residues [nucleotide binding]
1215914005030	dimerization interface [polypeptide binding]; other site
1215914005031	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1215914005032	Histidine kinase; Region: HisKA_3; pfam07730
1215914005033	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1215914005034	ATP binding site [chemical binding]; other site
1215914005035	Mg2+ binding site [ion binding]; other site
1215914005036	G-X-G motif; other site
1215914005037	Predicted membrane protein [Function unknown]; Region: COG4758
1215914005038	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
1215914005039	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1215914005040	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1215914005041	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1215914005042	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1215914005043	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
1215914005044	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1215914005045	ATP-binding site [chemical binding]; other site
1215914005046	Sugar specificity; other site
1215914005047	Pyrimidine base specificity; other site
1215914005048	YceG-like family; Region: YceG; pfam02618
1215914005049	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1215914005050	dimerization interface [polypeptide binding]; other site
1215914005051	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1215914005052	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1215914005053	putative tRNA-binding site [nucleotide binding]; other site
1215914005054	B3/4 domain; Region: B3_4; pfam03483
1215914005055	tRNA synthetase B5 domain; Region: B5; smart00874
1215914005056	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1215914005057	dimer interface [polypeptide binding]; other site
1215914005058	motif 1; other site
1215914005059	motif 3; other site
1215914005060	motif 2; other site
1215914005061	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1215914005062	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1215914005063	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1215914005064	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1215914005065	dimer interface [polypeptide binding]; other site
1215914005066	motif 1; other site
1215914005067	active site
1215914005068	motif 2; other site
1215914005069	motif 3; other site
1215914005070	Predicted transcriptional regulators [Transcription]; Region: COG1733
1215914005071	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1215914005072	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1215914005073	Zn2+ binding site [ion binding]; other site
1215914005074	Mg2+ binding site [ion binding]; other site
1215914005075	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1215914005076	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1215914005077	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1215914005078	Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254
1215914005079	OxaA-like protein precursor; Provisional; Region: PRK02463
1215914005080	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1215914005081	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1215914005082	HAMP domain; Region: HAMP; pfam00672
1215914005083	dimerization interface [polypeptide binding]; other site
1215914005084	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1215914005085	dimer interface [polypeptide binding]; other site
1215914005086	phosphorylation site [posttranslational modification]
1215914005087	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1215914005088	ATP binding site [chemical binding]; other site
1215914005089	Mg2+ binding site [ion binding]; other site
1215914005090	G-X-G motif; other site
1215914005091	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1215914005092	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1215914005093	active site
1215914005094	phosphorylation site [posttranslational modification]
1215914005095	intermolecular recognition site; other site
1215914005096	dimerization interface [polypeptide binding]; other site
1215914005097	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1215914005098	DNA binding site [nucleotide binding]
1215914005099	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1215914005100	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1215914005101	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1215914005102	Protein of unknown function (DUF3781); Region: DUF3781; pfam12636
1215914005103	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
1215914005104	hypothetical protein; Provisional; Region: PRK13670
1215914005105	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
1215914005106	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
1215914005107	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1215914005108	S-adenosylmethionine binding site [chemical binding]; other site
1215914005109	Oligomerisation domain; Region: Oligomerisation; pfam02410
1215914005110	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1215914005111	Zn2+ binding site [ion binding]; other site
1215914005112	Mg2+ binding site [ion binding]; other site
1215914005113	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1215914005114	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1215914005115	active site
1215914005116	(T/H)XGH motif; other site
1215914005117	GTPase YqeH; Provisional; Region: PRK13796
1215914005118	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
1215914005119	GTP/Mg2+ binding site [chemical binding]; other site
1215914005120	G4 box; other site
1215914005121	G5 box; other site
1215914005122	G1 box; other site
1215914005123	Switch I region; other site
1215914005124	G2 box; other site
1215914005125	G3 box; other site
1215914005126	Switch II region; other site
1215914005127	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1215914005128	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1215914005129	Zn binding site [ion binding]; other site
1215914005130	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1215914005131	Zn binding site [ion binding]; other site
1215914005132	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1215914005133	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1215914005134	Zn binding site [ion binding]; other site
1215914005135	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1215914005136	Zn binding site [ion binding]; other site
1215914005137	Predicted esterase [General function prediction only]; Region: COG0400
1215914005138	putative hydrolase; Provisional; Region: PRK11460
1215914005139	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1215914005140	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1215914005141	putative NAD(P) binding site [chemical binding]; other site
1215914005142	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
1215914005143	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1215914005144	23S rRNA binding site [nucleotide binding]; other site
1215914005145	L21 binding site [polypeptide binding]; other site
1215914005146	L13 binding site [polypeptide binding]; other site
1215914005147	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1215914005148	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1215914005149	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1215914005150	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1215914005151	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1215914005152	catalytic core [active]
1215914005153	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1215914005154	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1215914005155	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1215914005156	active site
1215914005157	dimer interface [polypeptide binding]; other site
1215914005158	motif 1; other site
1215914005159	motif 2; other site
1215914005160	motif 3; other site
1215914005161	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1215914005162	anticodon binding site; other site
1215914005163	primosomal protein DnaI; Reviewed; Region: PRK08939
1215914005164	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
1215914005165	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1215914005166	Walker A motif; other site
1215914005167	ATP binding site [chemical binding]; other site
1215914005168	Walker B motif; other site
1215914005169	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
1215914005170	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
1215914005171	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1215914005172	ATP cone domain; Region: ATP-cone; pfam03477
1215914005173	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1215914005174	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1215914005175	CoA-binding site [chemical binding]; other site
1215914005176	ATP-binding [chemical binding]; other site
1215914005177	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1215914005178	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1215914005179	DNA binding site [nucleotide binding]
1215914005180	catalytic residue [active]
1215914005181	H2TH interface [polypeptide binding]; other site
1215914005182	putative catalytic residues [active]
1215914005183	turnover-facilitating residue; other site
1215914005184	intercalation triad [nucleotide binding]; other site
1215914005185	8OG recognition residue [nucleotide binding]; other site
1215914005186	putative reading head residues; other site
1215914005187	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1215914005188	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1215914005189	DNA polymerase I; Provisional; Region: PRK05755
1215914005190	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1215914005191	active site
1215914005192	metal binding site 1 [ion binding]; metal-binding site
1215914005193	putative 5' ssDNA interaction site; other site
1215914005194	metal binding site 3; metal-binding site
1215914005195	metal binding site 2 [ion binding]; metal-binding site
1215914005196	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1215914005197	putative DNA binding site [nucleotide binding]; other site
1215914005198	putative metal binding site [ion binding]; other site
1215914005199	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1215914005200	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1215914005201	active site
1215914005202	DNA binding site [nucleotide binding]
1215914005203	catalytic site [active]
1215914005204	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1215914005205	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
1215914005206	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1215914005207	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1215914005208	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1215914005209	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1215914005210	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1215914005211	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1215914005212	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
1215914005213	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1215914005214	putative tRNA-binding site [nucleotide binding]; other site
1215914005215	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1215914005216	catalytic residues [active]
1215914005217	Predicted small secreted protein [Function unknown]; Region: COG5584
1215914005218	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1215914005219	S-adenosylmethionine binding site [chemical binding]; other site
1215914005220	Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510
1215914005221	Phosphotransferase enzyme family; Region: APH; pfam01636
1215914005222	substrate binding site [chemical binding]; other site
1215914005223	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
1215914005224	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1215914005225	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1215914005226	Walker A/P-loop; other site
1215914005227	ATP binding site [chemical binding]; other site
1215914005228	Q-loop/lid; other site
1215914005229	ABC transporter signature motif; other site
1215914005230	Walker B; other site
1215914005231	D-loop; other site
1215914005232	H-loop/switch region; other site
1215914005233	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1215914005234	HIT family signature motif; other site
1215914005235	catalytic residue [active]
1215914005236	YtxH-like protein; Region: YtxH; pfam12732
1215914005237	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
1215914005238	SurA N-terminal domain; Region: SurA_N_3; cl07813
1215914005239	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1215914005240	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
1215914005241	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
1215914005242	generic binding surface I; other site
1215914005243	generic binding surface II; other site
1215914005244	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1215914005245	Zn2+ binding site [ion binding]; other site
1215914005246	Mg2+ binding site [ion binding]; other site
1215914005247	Protein of unknown function (DUF964); Region: DUF964; cl01483
1215914005248	Transglycosylase; Region: Transgly; pfam00912
1215914005249	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1215914005250	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1215914005251	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1215914005252	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1215914005253	active site
1215914005254	Arginine repressor [Transcription]; Region: ArgR; COG1438
1215914005255	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1215914005256	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1215914005257	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
1215914005258	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1215914005259	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1215914005260	active site
1215914005261	HIGH motif; other site
1215914005262	KMSK motif region; other site
1215914005263	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1215914005264	tRNA binding surface [nucleotide binding]; other site
1215914005265	anticodon binding site; other site
1215914005266	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
1215914005267	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
1215914005268	active site
1215914005269	FMN binding site [chemical binding]; other site
1215914005270	substrate binding site [chemical binding]; other site
1215914005271	catalytic residues [active]
1215914005272	homodimer interface [polypeptide binding]; other site
1215914005273	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110
1215914005274	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1215914005275	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
1215914005276	putative active site [active]
1215914005277	catalytic site [active]
1215914005278	putative metal binding site [ion binding]; other site
1215914005279	adaptor protein; Provisional; Region: PRK02315
1215914005280	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1215914005281	ArsC family; Region: ArsC; pfam03960
1215914005282	putative catalytic residues [active]
1215914005283	thiol/disulfide switch; other site
1215914005284	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1215914005285	FtsX-like permease family; Region: FtsX; pfam02687
1215914005286	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914005287	H-loop/switch region; other site
1215914005288	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1215914005289	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1215914005290	Walker A/P-loop; other site
1215914005291	ATP binding site [chemical binding]; other site
1215914005292	ABC transporter; Region: ABC_tran; pfam00005
1215914005293	Q-loop/lid; other site
1215914005294	ABC transporter signature motif; other site
1215914005295	Walker B; other site
1215914005296	D-loop; other site
1215914005297	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1215914005298	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1215914005299	active site
1215914005300	phosphorylation site [posttranslational modification]
1215914005301	intermolecular recognition site; other site
1215914005302	dimerization interface [polypeptide binding]; other site
1215914005303	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1215914005304	DNA binding site [nucleotide binding]
1215914005305	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1215914005306	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1215914005307	ATP binding site [chemical binding]; other site
1215914005308	Mg2+ binding site [ion binding]; other site
1215914005309	G-X-G motif; other site
1215914005310	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
1215914005311	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
1215914005312	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1215914005313	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1215914005314	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1215914005315	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1215914005316	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1215914005317	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1215914005318	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1215914005319	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1215914005320	purine monophosphate binding site [chemical binding]; other site
1215914005321	dimer interface [polypeptide binding]; other site
1215914005322	putative catalytic residues [active]
1215914005323	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1215914005324	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1215914005325	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
1215914005326	catalytic site [active]
1215914005327	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1215914005328	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1215914005329	dimerization interface [polypeptide binding]; other site
1215914005330	putative ATP binding site [chemical binding]; other site
1215914005331	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1215914005332	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1215914005333	dimerization interface [polypeptide binding]; other site
1215914005334	ATP binding site [chemical binding]; other site
1215914005335	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1215914005336	dimerization interface [polypeptide binding]; other site
1215914005337	ATP binding site [chemical binding]; other site
1215914005338	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1215914005339	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1215914005340	putative active site [active]
1215914005341	catalytic triad [active]
1215914005342	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
1215914005343	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1215914005344	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1215914005345	ATP binding site [chemical binding]; other site
1215914005346	active site
1215914005347	substrate binding site [chemical binding]; other site
1215914005348	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1215914005349	ATP-grasp domain; Region: ATP-grasp; pfam02222
1215914005350	AIR carboxylase; Region: AIRC; pfam00731
1215914005351	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515
1215914005352	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
1215914005353	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914005354	putative substrate translocation pore; other site
1215914005355	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914005356	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1215914005357	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1215914005358	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1215914005359	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1215914005360	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1215914005361	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1215914005362	dimerization domain swap beta strand [polypeptide binding]; other site
1215914005363	regulatory protein interface [polypeptide binding]; other site
1215914005364	active site
1215914005365	regulatory phosphorylation site [posttranslational modification]; other site
1215914005366	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1215914005367	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1215914005368	Walker A motif; other site
1215914005369	ATP binding site [chemical binding]; other site
1215914005370	Walker B motif; other site
1215914005371	arginine finger; other site
1215914005372	UvrB/uvrC motif; Region: UVR; pfam02151
1215914005373	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1215914005374	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1215914005375	Walker B motif; other site
1215914005376	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1215914005377	Domain of unknown function (DUF1827); Region: DUF1827; pfam08860
1215914005378	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1215914005379	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1215914005380	G1 box; other site
1215914005381	putative GEF interaction site [polypeptide binding]; other site
1215914005382	GTP/Mg2+ binding site [chemical binding]; other site
1215914005383	Switch I region; other site
1215914005384	G2 box; other site
1215914005385	G3 box; other site
1215914005386	Switch II region; other site
1215914005387	G4 box; other site
1215914005388	G5 box; other site
1215914005389	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1215914005390	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1215914005391	Domain of unknown function DUF21; Region: DUF21; pfam01595
1215914005392	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1215914005393	Transporter associated domain; Region: CorC_HlyC; pfam03471
1215914005394	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1215914005395	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1215914005396	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1215914005397	Coenzyme A binding pocket [chemical binding]; other site
1215914005398	hypothetical protein; Provisional; Region: PRK13662
1215914005399	RecX family; Region: RecX; cl00936
1215914005400	Mga helix-turn-helix domain; Region: Mga; pfam05043
1215914005401	TRAM domain; Region: TRAM; pfam01938
1215914005402	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1215914005403	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1215914005404	S-adenosylmethionine binding site [chemical binding]; other site
1215914005405	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
1215914005406	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1215914005407	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1215914005408	DNA-binding site [nucleotide binding]; DNA binding site
1215914005409	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1215914005410	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1215914005411	beta-galactosidase; Region: BGL; TIGR03356
1215914005412	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1215914005413	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1215914005414	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1215914005415	active site
1215914005416	methionine cluster; other site
1215914005417	phosphorylation site [posttranslational modification]
1215914005418	metal binding site [ion binding]; metal-binding site
1215914005419	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1215914005420	active site
1215914005421	P-loop; other site
1215914005422	phosphorylation site [posttranslational modification]
1215914005423	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1215914005424	pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720
1215914005425	PYR/PP interface [polypeptide binding]; other site
1215914005426	dimer interface [polypeptide binding]; other site
1215914005427	tetramer interface [polypeptide binding]; other site
1215914005428	TPP binding site [chemical binding]; other site
1215914005429	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1215914005430	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1215914005431	TPP-binding site [chemical binding]; other site
1215914005432	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
1215914005433	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
1215914005434	dimer interface [polypeptide binding]; other site
1215914005435	active site
1215914005436	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
1215914005437	homodimer interface [polypeptide binding]; other site
1215914005438	catalytic residues [active]
1215914005439	NAD binding site [chemical binding]; other site
1215914005440	substrate binding pocket [chemical binding]; other site
1215914005441	flexible flap; other site
1215914005442	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1215914005443	Restriction endonuclease; Region: Mrr_cat; pfam04471
1215914005444	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
1215914005445	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
1215914005446	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
1215914005447	metal binding site [ion binding]; metal-binding site
1215914005448	dimer interface [polypeptide binding]; other site
1215914005449	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1215914005450	Predicted membrane protein [Function unknown]; Region: COG4684
1215914005451	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1215914005452	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1215914005453	Coenzyme A binding pocket [chemical binding]; other site
1215914005454	hypothetical protein; Provisional; Region: PRK04351
1215914005455	SprT homologues; Region: SprT; cl01182
1215914005456	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
1215914005457	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914005458	Walker A/P-loop; other site
1215914005459	ATP binding site [chemical binding]; other site
1215914005460	Q-loop/lid; other site
1215914005461	ABC transporter signature motif; other site
1215914005462	Walker B; other site
1215914005463	D-loop; other site
1215914005464	H-loop/switch region; other site
1215914005465	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
1215914005466	TM-ABC transporter signature motif; other site
1215914005467	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
1215914005468	zinc binding site [ion binding]; other site
1215914005469	putative ligand binding site [chemical binding]; other site
1215914005470	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
1215914005471	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1215914005472	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1215914005473	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1215914005474	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1215914005475	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1215914005476	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1215914005477	Beta-lactamase; Region: Beta-lactamase; pfam00144
1215914005478	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1215914005479	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1215914005480	homodimer interface [polypeptide binding]; other site
1215914005481	NAD binding pocket [chemical binding]; other site
1215914005482	ATP binding pocket [chemical binding]; other site
1215914005483	Mg binding site [ion binding]; other site
1215914005484	active-site loop [active]
1215914005485	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1215914005486	Beta-lactamase; Region: Beta-lactamase; pfam00144
1215914005487	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1215914005488	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1215914005489	active site
1215914005490	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1215914005491	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1215914005492	DNA-binding site [nucleotide binding]; DNA binding site
1215914005493	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1215914005494	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1215914005495	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1215914005496	active site
1215914005497	dimer interface [polypeptide binding]; other site
1215914005498	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
1215914005499	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1215914005500	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
1215914005501	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1215914005502	putative phosphoesterase; Region: acc_ester; TIGR03729
1215914005503	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1215914005504	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1215914005505	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914005506	putative substrate translocation pore; other site
1215914005507	POT family; Region: PTR2; pfam00854
1215914005508	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1215914005509	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1215914005510	Walker A/P-loop; other site
1215914005511	ATP binding site [chemical binding]; other site
1215914005512	Q-loop/lid; other site
1215914005513	ABC transporter signature motif; other site
1215914005514	Walker B; other site
1215914005515	D-loop; other site
1215914005516	H-loop/switch region; other site
1215914005517	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1215914005518	FtsX-like permease family; Region: FtsX; pfam02687
1215914005519	MFS/sugar transport protein; Region: MFS_2; pfam13347
1215914005520	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
1215914005521	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
1215914005522	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
1215914005523	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1215914005524	catalytic residues [active]
1215914005525	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
1215914005526	active site
1215914005527	nucleotide-binding site [chemical binding]; other site
1215914005528	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1215914005529	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1215914005530	G1 box; other site
1215914005531	GTP/Mg2+ binding site [chemical binding]; other site
1215914005532	Switch I region; other site
1215914005533	G2 box; other site
1215914005534	G3 box; other site
1215914005535	Switch II region; other site
1215914005536	G4 box; other site
1215914005537	G5 box; other site
1215914005538	Nucleoside recognition; Region: Gate; pfam07670
1215914005539	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1215914005540	Nucleoside recognition; Region: Gate; pfam07670
1215914005541	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
1215914005542	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1215914005543	catalytic triad [active]
1215914005544	catalytic triad [active]
1215914005545	oxyanion hole [active]
1215914005546	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1215914005547	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1215914005548	NAD binding site [chemical binding]; other site
1215914005549	substrate binding site [chemical binding]; other site
1215914005550	putative active site [active]
1215914005551	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1215914005552	Domain of unknown function (DUF4330); Region: DUF4330; pfam14221
1215914005553	seryl-tRNA synthetase; Provisional; Region: PRK05431
1215914005554	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1215914005555	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1215914005556	dimer interface [polypeptide binding]; other site
1215914005557	active site
1215914005558	motif 1; other site
1215914005559	motif 2; other site
1215914005560	motif 3; other site
1215914005561	Mga helix-turn-helix domain; Region: Mga; pfam05043
1215914005562	Mga helix-turn-helix domain; Region: Mga; pfam05043
1215914005563	lysine transporter; Provisional; Region: PRK10836
1215914005564	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
1215914005565	acetolactate synthase; Reviewed; Region: PRK08617
1215914005566	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1215914005567	PYR/PP interface [polypeptide binding]; other site
1215914005568	dimer interface [polypeptide binding]; other site
1215914005569	TPP binding site [chemical binding]; other site
1215914005570	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1215914005571	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1215914005572	TPP-binding site [chemical binding]; other site
1215914005573	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1215914005574	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1215914005575	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
1215914005576	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
1215914005577	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1215914005578	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1215914005579	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1215914005580	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1215914005581	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1215914005582	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1215914005583	active site
1215914005584	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1215914005585	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1215914005586	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
1215914005587	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
1215914005588	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1215914005589	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1215914005590	DNA-binding site [nucleotide binding]; DNA binding site
1215914005591	FCD domain; Region: FCD; pfam07729
1215914005592	oxaloacetate decarboxylase; Provisional; Region: PRK12331
1215914005593	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1215914005594	active site
1215914005595	catalytic residues [active]
1215914005596	metal binding site [ion binding]; metal-binding site
1215914005597	homodimer binding site [polypeptide binding]; other site
1215914005598	2'-(5''-triphosphoribosyl)-3'- dephospho-CoA:apo-citrate lyase; Reviewed; Region: citX; PRK01392
1215914005599	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
1215914005600	Coenzyme A transferase; Region: CoA_trans; cl17247
1215914005601	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1215914005602	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
1215914005603	citrate lyase subunit gamma; Provisional; Region: PRK13253
1215914005604	[citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124
1215914005605	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1215914005606	active site
1215914005607	nucleotide binding site [chemical binding]; other site
1215914005608	HIGH motif; other site
1215914005609	KMSKS motif; other site
1215914005610	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
1215914005611	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549
1215914005612	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1215914005613	carboxyltransferase (CT) interaction site; other site
1215914005614	biotinylation site [posttranslational modification]; other site
1215914005615	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
1215914005616	Citrate transporter; Region: CitMHS; pfam03600
1215914005617	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
1215914005618	RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885
1215914005619	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
1215914005620	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1215914005621	Coenzyme A binding pocket [chemical binding]; other site
1215914005622	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
1215914005623	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1215914005624	Predicted transcriptional regulators [Transcription]; Region: COG1695
1215914005625	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1215914005626	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1215914005627	dimer interface [polypeptide binding]; other site
1215914005628	FMN binding site [chemical binding]; other site
1215914005629	NADPH bind site [chemical binding]; other site
1215914005630	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1215914005631	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1215914005632	Walker A/P-loop; other site
1215914005633	ATP binding site [chemical binding]; other site
1215914005634	Q-loop/lid; other site
1215914005635	ABC transporter signature motif; other site
1215914005636	Walker B; other site
1215914005637	D-loop; other site
1215914005638	H-loop/switch region; other site
1215914005639	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
1215914005640	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1215914005641	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1215914005642	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914005643	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1215914005644	putative substrate translocation pore; other site
1215914005645	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914005646	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1215914005647	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1215914005648	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914005649	non-specific DNA binding site [nucleotide binding]; other site
1215914005650	salt bridge; other site
1215914005651	sequence-specific DNA binding site [nucleotide binding]; other site
1215914005652	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
1215914005653	Predicted transcriptional regulators [Transcription]; Region: COG1725
1215914005654	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1215914005655	DNA-binding site [nucleotide binding]; DNA binding site
1215914005656	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1215914005657	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914005658	Walker A/P-loop; other site
1215914005659	ATP binding site [chemical binding]; other site
1215914005660	Q-loop/lid; other site
1215914005661	ABC transporter signature motif; other site
1215914005662	Walker B; other site
1215914005663	D-loop; other site
1215914005664	H-loop/switch region; other site
1215914005665	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1215914005666	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1215914005667	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1215914005668	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1215914005669	Walker A/P-loop; other site
1215914005670	ATP binding site [chemical binding]; other site
1215914005671	Q-loop/lid; other site
1215914005672	ABC transporter signature motif; other site
1215914005673	Walker B; other site
1215914005674	D-loop; other site
1215914005675	H-loop/switch region; other site
1215914005676	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1215914005677	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1215914005678	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1215914005679	Walker A/P-loop; other site
1215914005680	ATP binding site [chemical binding]; other site
1215914005681	Q-loop/lid; other site
1215914005682	ABC transporter signature motif; other site
1215914005683	Walker B; other site
1215914005684	D-loop; other site
1215914005685	H-loop/switch region; other site
1215914005686	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1215914005687	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1215914005688	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914005689	dimer interface [polypeptide binding]; other site
1215914005690	conserved gate region; other site
1215914005691	putative PBP binding loops; other site
1215914005692	ABC-ATPase subunit interface; other site
1215914005693	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1215914005694	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914005695	dimer interface [polypeptide binding]; other site
1215914005696	conserved gate region; other site
1215914005697	putative PBP binding loops; other site
1215914005698	ABC-ATPase subunit interface; other site
1215914005699	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1215914005700	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1215914005701	peptide binding site [polypeptide binding]; other site
1215914005702	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1215914005703	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
1215914005704	potential catalytic triad [active]
1215914005705	conserved cys residue [active]
1215914005706	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1215914005707	putative DNA binding site [nucleotide binding]; other site
1215914005708	putative Zn2+ binding site [ion binding]; other site
1215914005709	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1215914005710	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
1215914005711	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914005712	Walker A/P-loop; other site
1215914005713	ATP binding site [chemical binding]; other site
1215914005714	Q-loop/lid; other site
1215914005715	ABC transporter signature motif; other site
1215914005716	Walker B; other site
1215914005717	D-loop; other site
1215914005718	H-loop/switch region; other site
1215914005719	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1215914005720	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1215914005721	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1215914005722	Walker A/P-loop; other site
1215914005723	ATP binding site [chemical binding]; other site
1215914005724	Q-loop/lid; other site
1215914005725	ABC transporter signature motif; other site
1215914005726	Walker B; other site
1215914005727	D-loop; other site
1215914005728	H-loop/switch region; other site
1215914005729	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1215914005730	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1215914005731	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
1215914005732	active site
1215914005733	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1215914005734	Helix-turn-helix domain; Region: HTH_38; pfam13936
1215914005735	Integrase core domain; Region: rve; pfam00665
1215914005736	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1215914005737	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1215914005738	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1215914005739	SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133
1215914005740	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1215914005741	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914005742	non-specific DNA binding site [nucleotide binding]; other site
1215914005743	salt bridge; other site
1215914005744	sequence-specific DNA binding site [nucleotide binding]; other site
1215914005745	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
1215914005746	Homeodomain-like domain; Region: HTH_23; cl17451
1215914005747	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1215914005748	Integrase core domain; Region: rve; pfam00665
1215914005749	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1215914005750	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1215914005751	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1215914005752	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1215914005753	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1215914005754	Helix-turn-helix domain; Region: HTH_38; pfam13936
1215914005755	Integrase core domain; Region: rve; pfam00665
1215914005756	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1215914005757	Transposase; Region: HTH_Tnp_1; pfam01527
1215914005758	HTH-like domain; Region: HTH_21; pfam13276
1215914005759	Integrase core domain; Region: rve; pfam00665
1215914005760	Integrase core domain; Region: rve_3; pfam13683
1215914005761	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1215914005762	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
1215914005763	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1215914005764	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
1215914005765	Cl binding site [ion binding]; other site
1215914005766	oligomer interface [polypeptide binding]; other site
1215914005767	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1215914005768	Helix-turn-helix domain; Region: HTH_38; pfam13936
1215914005769	Integrase core domain; Region: rve; pfam00665
1215914005770	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
1215914005771	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1215914005772	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_2; cd08769
1215914005773	SxDxEG motif; other site
1215914005774	putative active site [active]
1215914005775	putative metal binding site [ion binding]; other site
1215914005776	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1215914005777	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
1215914005778	oligomer interface [polypeptide binding]; other site
1215914005779	active site
1215914005780	metal binding site [ion binding]; metal-binding site
1215914005781	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1215914005782	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1215914005783	peptide binding site [polypeptide binding]; other site
1215914005784	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1215914005785	Integrase core domain; Region: rve; pfam00665
1215914005786	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1215914005787	Helix-turn-helix domain; Region: HTH_16; pfam12645
1215914005788	Domain of unknown function (DUF3173); Region: DUF3173; pfam11372
1215914005789	PAZ domain, named PAZ after the proteins Piwi Argonaut and Zwille. PAZ is found in two families of proteins that are essential components of RNA-mediated gene-silencing pathways, including RNA interference, the piwi and Dicer families. PAZ functions as a...; Region: PAZ; cl00301
1215914005790	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
1215914005791	nucleic acid-binding interface [nucleotide binding]; other site
1215914005792	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1215914005793	Int/Topo IB signature motif; other site
1215914005794	GMP synthase; Reviewed; Region: guaA; PRK00074
1215914005795	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1215914005796	AMP/PPi binding site [chemical binding]; other site
1215914005797	candidate oxyanion hole; other site
1215914005798	catalytic triad [active]
1215914005799	potential glutamine specificity residues [chemical binding]; other site
1215914005800	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1215914005801	ATP Binding subdomain [chemical binding]; other site
1215914005802	Dimerization subdomain; other site
1215914005803	pantothenate kinase; Provisional; Region: PRK05439
1215914005804	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
1215914005805	ATP-binding site [chemical binding]; other site
1215914005806	CoA-binding site [chemical binding]; other site
1215914005807	Mg2+-binding site [ion binding]; other site
1215914005808	Peptidase family C69; Region: Peptidase_C69; pfam03577
1215914005809	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1215914005810	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
1215914005811	Part of AAA domain; Region: AAA_19; pfam13245
1215914005812	Family description; Region: UvrD_C_2; pfam13538
1215914005813	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1215914005814	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1215914005815	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1215914005816	TrkA-C domain; Region: TrkA_C; pfam02080
1215914005817	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
1215914005818	manganese transport protein MntH; Reviewed; Region: PRK00701
1215914005819	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1215914005820	Ferrochelatase; Region: Ferrochelatase; pfam00762
1215914005821	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1215914005822	C-terminal domain interface [polypeptide binding]; other site
1215914005823	active site
1215914005824	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1215914005825	active site
1215914005826	N-terminal domain interface [polypeptide binding]; other site
1215914005827	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1215914005828	catalytic core [active]
1215914005829	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1215914005830	FtsX-like permease family; Region: FtsX; pfam02687
1215914005831	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1215914005832	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1215914005833	Walker A/P-loop; other site
1215914005834	ATP binding site [chemical binding]; other site
1215914005835	Q-loop/lid; other site
1215914005836	ABC transporter signature motif; other site
1215914005837	Walker B; other site
1215914005838	D-loop; other site
1215914005839	H-loop/switch region; other site
1215914005840	Amino acid permease; Region: AA_permease_2; pfam13520
1215914005841	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1215914005842	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1215914005843	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1215914005844	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1215914005845	HflX GTPase family; Region: HflX; cd01878
1215914005846	G1 box; other site
1215914005847	GTP/Mg2+ binding site [chemical binding]; other site
1215914005848	Switch I region; other site
1215914005849	G2 box; other site
1215914005850	G3 box; other site
1215914005851	Switch II region; other site
1215914005852	G4 box; other site
1215914005853	G5 box; other site
1215914005854	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1215914005855	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
1215914005856	NodB motif; other site
1215914005857	active site
1215914005858	catalytic site [active]
1215914005859	Zn binding site [ion binding]; other site
1215914005860	Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264
1215914005861	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
1215914005862	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
1215914005863	putative active site [active]
1215914005864	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1215914005865	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1215914005866	NADP binding site [chemical binding]; other site
1215914005867	active site
1215914005868	putative substrate binding site [chemical binding]; other site
1215914005869	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1215914005870	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1215914005871	NAD binding site [chemical binding]; other site
1215914005872	substrate binding site [chemical binding]; other site
1215914005873	homodimer interface [polypeptide binding]; other site
1215914005874	active site
1215914005875	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
1215914005876	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1215914005877	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1215914005878	substrate binding site; other site
1215914005879	tetramer interface; other site
1215914005880	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1215914005881	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1215914005882	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1215914005883	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1215914005884	NAD(P) binding site [chemical binding]; other site
1215914005885	active site
1215914005886	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1215914005887	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914005888	dimer interface [polypeptide binding]; other site
1215914005889	conserved gate region; other site
1215914005890	putative PBP binding loops; other site
1215914005891	ABC-ATPase subunit interface; other site
1215914005892	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1215914005893	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914005894	dimer interface [polypeptide binding]; other site
1215914005895	conserved gate region; other site
1215914005896	putative PBP binding loops; other site
1215914005897	ABC-ATPase subunit interface; other site
1215914005898	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1215914005899	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1215914005900	substrate binding pocket [chemical binding]; other site
1215914005901	membrane-bound complex binding site; other site
1215914005902	hinge residues; other site
1215914005903	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1215914005904	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1215914005905	Walker A/P-loop; other site
1215914005906	ATP binding site [chemical binding]; other site
1215914005907	Q-loop/lid; other site
1215914005908	ABC transporter signature motif; other site
1215914005909	Walker B; other site
1215914005910	D-loop; other site
1215914005911	H-loop/switch region; other site
1215914005912	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1215914005913	metal binding site 2 [ion binding]; metal-binding site
1215914005914	putative DNA binding helix; other site
1215914005915	metal binding site 1 [ion binding]; metal-binding site
1215914005916	dimer interface [polypeptide binding]; other site
1215914005917	structural Zn2+ binding site [ion binding]; other site
1215914005918	Guanylate kinase; Region: Guanylate_kin; pfam00625
1215914005919	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1215914005920	active site
1215914005921	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1215914005922	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1215914005923	Coenzyme A binding pocket [chemical binding]; other site
1215914005924	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
1215914005925	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1215914005926	NlpC/P60 family; Region: NLPC_P60; pfam00877
1215914005927	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
1215914005928	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1215914005929	active site
1215914005930	KMSKS motif; other site
1215914005931	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1215914005932	RNA binding surface [nucleotide binding]; other site
1215914005933	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1215914005934	active site
1215914005935	HIGH motif; other site
1215914005936	nucleotide binding site [chemical binding]; other site
1215914005937	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1215914005938	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1215914005939	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1215914005940	dimerization interface [polypeptide binding]; other site
1215914005941	putative DNA binding site [nucleotide binding]; other site
1215914005942	putative Zn2+ binding site [ion binding]; other site
1215914005943	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
1215914005944	ApbE family; Region: ApbE; pfam02424
1215914005945	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1215914005946	active site
1215914005947	homodimer interface [polypeptide binding]; other site
1215914005948	catalytic site [active]
1215914005949	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1215914005950	homodimer interface [polypeptide binding]; other site
1215914005951	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
1215914005952	active site pocket [active]
1215914005953	glycogen synthase; Provisional; Region: glgA; PRK00654
1215914005954	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1215914005955	ADP-binding pocket [chemical binding]; other site
1215914005956	homodimer interface [polypeptide binding]; other site
1215914005957	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
1215914005958	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1215914005959	active site
1215914005960	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1215914005961	dimer interface [polypeptide binding]; other site
1215914005962	N-terminal domain interface [polypeptide binding]; other site
1215914005963	sulfate 1 binding site; other site
1215914005964	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
1215914005965	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1215914005966	ligand binding site; other site
1215914005967	oligomer interface; other site
1215914005968	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1215914005969	dimer interface [polypeptide binding]; other site
1215914005970	N-terminal domain interface [polypeptide binding]; other site
1215914005971	sulfate 1 binding site; other site
1215914005972	glycogen branching enzyme; Provisional; Region: PRK12313
1215914005973	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1215914005974	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1215914005975	active site
1215914005976	catalytic site [active]
1215914005977	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1215914005978	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1215914005979	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1215914005980	homodimer interface [polypeptide binding]; other site
1215914005981	substrate-cofactor binding pocket; other site
1215914005982	catalytic residue [active]
1215914005983	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
1215914005984	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1215914005985	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1215914005986	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1215914005987	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
1215914005988	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1215914005989	ArsC family; Region: ArsC; pfam03960
1215914005990	putative catalytic residues [active]
1215914005991	thiol/disulfide switch; other site
1215914005992	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1215914005993	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1215914005994	Walker A motif; other site
1215914005995	ATP binding site [chemical binding]; other site
1215914005996	Walker B motif; other site
1215914005997	arginine finger; other site
1215914005998	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1215914005999	Walker A motif; other site
1215914006000	ATP binding site [chemical binding]; other site
1215914006001	Walker B motif; other site
1215914006002	arginine finger; other site
1215914006003	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1215914006004	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
1215914006005	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1215914006006	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1215914006007	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1215914006008	Transposase domain (DUF772); Region: DUF772; pfam05598
1215914006009	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1215914006010	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
1215914006011	Homeodomain-like domain; Region: HTH_23; pfam13384
1215914006012	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1215914006013	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1215914006014	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1215914006015	NADP binding site [chemical binding]; other site
1215914006016	active site
1215914006017	putative substrate binding site [chemical binding]; other site
1215914006018	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1215914006019	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1215914006020	NAD binding site [chemical binding]; other site
1215914006021	substrate binding site [chemical binding]; other site
1215914006022	homodimer interface [polypeptide binding]; other site
1215914006023	active site
1215914006024	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
1215914006025	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1215914006026	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1215914006027	substrate binding site; other site
1215914006028	tetramer interface; other site
1215914006029	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1215914006030	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1215914006031	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1215914006032	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1215914006033	active site
1215914006034	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1215914006035	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1215914006036	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1215914006037	trimer interface [polypeptide binding]; other site
1215914006038	active site
1215914006039	substrate binding site [chemical binding]; other site
1215914006040	CoA binding site [chemical binding]; other site
1215914006041	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1215914006042	active site
1215914006043	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1215914006044	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1215914006045	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1215914006046	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
1215914006047	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1215914006048	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1215914006049	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1215914006050	Chain length determinant protein; Region: Wzz; cl15801
1215914006051	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
1215914006052	catalytic triad [active]
1215914006053	catalytic triad [active]
1215914006054	oxyanion hole [active]
1215914006055	QueT transporter; Region: QueT; pfam06177
1215914006056	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
1215914006057	classical (c) SDRs; Region: SDR_c; cd05233
1215914006058	NAD(P) binding site [chemical binding]; other site
1215914006059	active site
1215914006060	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
1215914006061	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1215914006062	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914006063	non-specific DNA binding site [nucleotide binding]; other site
1215914006064	salt bridge; other site
1215914006065	sequence-specific DNA binding site [nucleotide binding]; other site
1215914006066	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1215914006067	catalytic core [active]
1215914006068	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1215914006069	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1215914006070	Walker A/P-loop; other site
1215914006071	ATP binding site [chemical binding]; other site
1215914006072	Q-loop/lid; other site
1215914006073	ABC transporter signature motif; other site
1215914006074	Walker B; other site
1215914006075	D-loop; other site
1215914006076	H-loop/switch region; other site
1215914006077	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1215914006078	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1215914006079	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1215914006080	Walker A/P-loop; other site
1215914006081	ATP binding site [chemical binding]; other site
1215914006082	Q-loop/lid; other site
1215914006083	ABC transporter signature motif; other site
1215914006084	Walker B; other site
1215914006085	D-loop; other site
1215914006086	H-loop/switch region; other site
1215914006087	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1215914006088	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1215914006089	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1215914006090	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914006091	dimer interface [polypeptide binding]; other site
1215914006092	conserved gate region; other site
1215914006093	putative PBP binding loops; other site
1215914006094	ABC-ATPase subunit interface; other site
1215914006095	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1215914006096	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914006097	dimer interface [polypeptide binding]; other site
1215914006098	conserved gate region; other site
1215914006099	putative PBP binding loops; other site
1215914006100	ABC-ATPase subunit interface; other site
1215914006101	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1215914006102	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1215914006103	peptide binding site [polypeptide binding]; other site
1215914006104	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1215914006105	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914006106	putative substrate translocation pore; other site
1215914006107	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1215914006108	Helix-turn-helix domain; Region: HTH_38; pfam13936
1215914006109	Integrase core domain; Region: rve; pfam00665
1215914006110	elongation factor P; Validated; Region: PRK00529
1215914006111	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1215914006112	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1215914006113	RNA binding site [nucleotide binding]; other site
1215914006114	Elongation factor P, C-terminal; Region: Elong-fact-P_C; pfam09285
1215914006115	RNA binding site [nucleotide binding]; other site
1215914006116	Uncharacterized conserved protein [Function unknown]; Region: COG1556
1215914006117	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
1215914006118	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1215914006119	4Fe-4S binding domain; Region: Fer4; pfam00037
1215914006120	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1215914006121	Cysteine-rich domain; Region: CCG; pfam02754
1215914006122	Cysteine-rich domain; Region: CCG; pfam02754
1215914006123	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1215914006124	active site
1215914006125	methionine cluster; other site
1215914006126	phosphorylation site [posttranslational modification]
1215914006127	metal binding site [ion binding]; metal-binding site
1215914006128	Uncharacterized conserved protein [Function unknown]; Region: COG3589
1215914006129	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
1215914006130	Domain of unknown function (DUF3284); Region: DUF3284; pfam11687
1215914006131	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1215914006132	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1215914006133	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
1215914006134	Melibiase; Region: Melibiase; pfam02065
1215914006135	hypothetical protein; Validated; Region: PRK02101
1215914006136	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1215914006137	DNA binding residues [nucleotide binding]
1215914006138	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1215914006139	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
1215914006140	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
1215914006141	AAA domain; Region: AAA_30; pfam13604
1215914006142	Family description; Region: UvrD_C_2; pfam13538
1215914006143	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1215914006144	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1215914006145	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1215914006146	substrate binding site [chemical binding]; other site
1215914006147	ATP binding site [chemical binding]; other site
1215914006148	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1215914006149	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1215914006150	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1215914006151	Uncharacterized conserved protein [Function unknown]; Region: COG3535
1215914006152	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1215914006153	Na binding site [ion binding]; other site
1215914006154	Protein of unknown function DUF262; Region: DUF262; pfam03235
1215914006155	Uncharacterized conserved protein [Function unknown]; Region: COG1479
1215914006156	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1215914006157	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1215914006158	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1215914006159	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1215914006160	Int/Topo IB signature motif; other site
1215914006161	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1215914006162	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1215914006163	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1215914006164	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1215914006165	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1215914006166	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1215914006167	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1215914006168	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1215914006169	ATP binding site [chemical binding]; other site
1215914006170	putative Mg++ binding site [ion binding]; other site
1215914006171	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
1215914006172	Protein of unknown function (DUF998); Region: DUF998; pfam06197
1215914006173	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1215914006174	HPr interaction site; other site
1215914006175	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1215914006176	active site
1215914006177	phosphorylation site [posttranslational modification]
1215914006178	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1215914006179	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1215914006180	active site turn [active]
1215914006181	phosphorylation site [posttranslational modification]
1215914006182	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1215914006183	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1215914006184	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1215914006185	Ca binding site [ion binding]; other site
1215914006186	active site
1215914006187	catalytic site [active]
1215914006188	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1215914006189	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1215914006190	DNA binding site [nucleotide binding]
1215914006191	domain linker motif; other site
1215914006192	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1215914006193	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
1215914006194	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1215914006195	substrate binding [chemical binding]; other site
1215914006196	active site
1215914006197	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1215914006198	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1215914006199	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1215914006200	NADP binding site [chemical binding]; other site
1215914006201	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1215914006202	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1215914006203	S-adenosylmethionine binding site [chemical binding]; other site
1215914006204	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1215914006205	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1215914006206	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1215914006207	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1215914006208	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1215914006209	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1215914006210	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1215914006211	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1215914006212	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1215914006213	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1215914006214	carboxyltransferase (CT) interaction site; other site
1215914006215	biotinylation site [posttranslational modification]; other site
1215914006216	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1215914006217	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1215914006218	dimer interface [polypeptide binding]; other site
1215914006219	active site
1215914006220	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1215914006221	active site
1215914006222	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1215914006223	NAD(P) binding site [chemical binding]; other site
1215914006224	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1215914006225	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1215914006226	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
1215914006227	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1215914006228	FMN binding site [chemical binding]; other site
1215914006229	substrate binding site [chemical binding]; other site
1215914006230	putative catalytic residue [active]
1215914006231	acyl carrier protein; Provisional; Region: acpP; PRK00982
1215914006232	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1215914006233	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1215914006234	dimer interface [polypeptide binding]; other site
1215914006235	active site
1215914006236	CoA binding pocket [chemical binding]; other site
1215914006237	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1215914006238	MarR family; Region: MarR_2; pfam12802
1215914006239	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1215914006240	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1215914006241	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
1215914006242	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
1215914006243	dimer interface [polypeptide binding]; other site
1215914006244	active site
1215914006245	metal binding site [ion binding]; metal-binding site
1215914006246	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1215914006247	Helix-turn-helix domain; Region: HTH_38; pfam13936
1215914006248	Integrase core domain; Region: rve; pfam00665
1215914006249	Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078
1215914006250	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1215914006251	MarR family; Region: MarR_2; pfam12802
1215914006252	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
1215914006253	S-formylglutathione hydrolase; Region: PLN02442
1215914006254	Putative esterase; Region: Esterase; pfam00756
1215914006255	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1215914006256	Double zinc ribbon; Region: DZR; pfam12773
1215914006257	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1215914006258	putative DNA binding site [nucleotide binding]; other site
1215914006259	putative Zn2+ binding site [ion binding]; other site
1215914006260	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1215914006261	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1215914006262	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914006263	Walker A/P-loop; other site
1215914006264	ATP binding site [chemical binding]; other site
1215914006265	Q-loop/lid; other site
1215914006266	ABC transporter signature motif; other site
1215914006267	Walker B; other site
1215914006268	D-loop; other site
1215914006269	H-loop/switch region; other site
1215914006270	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
1215914006271	nudix motif; other site
1215914006272	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1215914006273	catalytic core [active]
1215914006274	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1215914006275	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1215914006276	Double zinc ribbon; Region: DZR; pfam12773
1215914006277	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1215914006278	Beta-lactamase; Region: Beta-lactamase; pfam00144
1215914006279	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
1215914006280	active site
1215914006281	catalytic site [active]
1215914006282	Predicted membrane protein [Function unknown]; Region: COG2246
1215914006283	GtrA-like protein; Region: GtrA; pfam04138
1215914006284	lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147
1215914006285	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1215914006286	Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440
1215914006287	pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720
1215914006288	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
1215914006289	PYR/PP interface [polypeptide binding]; other site
1215914006290	dimer interface [polypeptide binding]; other site
1215914006291	TPP binding site [chemical binding]; other site
1215914006292	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1215914006293	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1215914006294	TPP-binding site [chemical binding]; other site
1215914006295	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1215914006296	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1215914006297	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1215914006298	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914006299	dimer interface [polypeptide binding]; other site
1215914006300	conserved gate region; other site
1215914006301	putative PBP binding loops; other site
1215914006302	ABC-ATPase subunit interface; other site
1215914006303	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
1215914006304	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
1215914006305	Walker A/P-loop; other site
1215914006306	ATP binding site [chemical binding]; other site
1215914006307	Q-loop/lid; other site
1215914006308	ABC transporter signature motif; other site
1215914006309	Walker B; other site
1215914006310	D-loop; other site
1215914006311	H-loop/switch region; other site
1215914006312	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1215914006313	DNA-binding protein, stimulates sugar fermentation [General function prediction only]; Region: SfsA; COG1489
1215914006314	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1215914006315	Ligand Binding Site [chemical binding]; other site
1215914006316	Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919
1215914006317	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1215914006318	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1215914006319	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
1215914006320	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1215914006321	catalytic residue [active]
1215914006322	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
1215914006323	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1215914006324	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1215914006325	aspartate kinase; Reviewed; Region: PRK09034
1215914006326	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
1215914006327	nucleotide binding site [chemical binding]; other site
1215914006328	substrate binding site [chemical binding]; other site
1215914006329	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1215914006330	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
1215914006331	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
1215914006332	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1215914006333	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
1215914006334	aromatic amino acid aminotransferase; Validated; Region: PRK07309
1215914006335	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1215914006336	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1215914006337	homodimer interface [polypeptide binding]; other site
1215914006338	catalytic residue [active]
1215914006339	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
1215914006340	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
1215914006341	nucleotide binding site/active site [active]
1215914006342	HIT family signature motif; other site
1215914006343	catalytic residue [active]
1215914006344	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
1215914006345	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1215914006346	active site
1215914006347	dimer interface [polypeptide binding]; other site
1215914006348	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1215914006349	Ligand Binding Site [chemical binding]; other site
1215914006350	Molecular Tunnel; other site
1215914006351	Predicted integral membrane protein [Function unknown]; Region: COG0392
1215914006352	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1215914006353	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1215914006354	active site
1215914006355	metal binding site [ion binding]; metal-binding site
1215914006356	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1215914006357	UbiA prenyltransferase family; Region: UbiA; pfam01040
1215914006358	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
1215914006359	aspartate-rich region 2; other site
1215914006360	substrate-Mg2+ binding site; other site
1215914006361	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1215914006362	propionate/acetate kinase; Provisional; Region: PRK12379
1215914006363	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1215914006364	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914006365	Walker A/P-loop; other site
1215914006366	ATP binding site [chemical binding]; other site
1215914006367	Q-loop/lid; other site
1215914006368	ABC transporter signature motif; other site
1215914006369	Walker B; other site
1215914006370	D-loop; other site
1215914006371	H-loop/switch region; other site
1215914006372	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1215914006373	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1215914006374	Predicted transcriptional regulators [Transcription]; Region: COG1725
1215914006375	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1215914006376	DNA-binding site [nucleotide binding]; DNA binding site
1215914006377	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1215914006378	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1215914006379	Walker A/P-loop; other site
1215914006380	ATP binding site [chemical binding]; other site
1215914006381	Q-loop/lid; other site
1215914006382	ABC transporter signature motif; other site
1215914006383	Walker B; other site
1215914006384	D-loop; other site
1215914006385	H-loop/switch region; other site
1215914006386	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
1215914006387	glucose-1-dehydrogenase; Provisional; Region: PRK08936
1215914006388	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
1215914006389	NAD binding site [chemical binding]; other site
1215914006390	homodimer interface [polypeptide binding]; other site
1215914006391	active site
1215914006392	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1215914006393	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1215914006394	hexamer interface [polypeptide binding]; other site
1215914006395	ligand binding site [chemical binding]; other site
1215914006396	putative active site [active]
1215914006397	NAD(P) binding site [chemical binding]; other site
1215914006398	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1215914006399	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1215914006400	tetramer interface [polypeptide binding]; other site
1215914006401	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1215914006402	catalytic residue [active]
1215914006403	OPT oligopeptide transporter protein; Region: OPT; cl14607
1215914006404	OPT oligopeptide transporter protein; Region: OPT; cl14607
1215914006405	OPT oligopeptide transporter protein; Region: OPT; cl14607
1215914006406	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
1215914006407	Peptidase family C69; Region: Peptidase_C69; pfam03577
1215914006408	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
1215914006409	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1215914006410	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1215914006411	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1215914006412	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914006413	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1215914006414	putative substrate translocation pore; other site
1215914006415	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1215914006416	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1215914006417	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1215914006418	beta-galactosidase; Region: BGL; TIGR03356
1215914006419	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1215914006420	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
1215914006421	active site turn [active]
1215914006422	phosphorylation site [posttranslational modification]
1215914006423	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1215914006424	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
1215914006425	HPr interaction site; other site
1215914006426	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1215914006427	active site
1215914006428	phosphorylation site [posttranslational modification]
1215914006429	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1215914006430	CAT RNA binding domain; Region: CAT_RBD; smart01061
1215914006431	PRD domain; Region: PRD; pfam00874
1215914006432	PRD domain; Region: PRD; pfam00874
1215914006433	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1215914006434	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1215914006435	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1215914006436	Walker A/P-loop; other site
1215914006437	ATP binding site [chemical binding]; other site
1215914006438	Q-loop/lid; other site
1215914006439	ABC transporter signature motif; other site
1215914006440	Walker B; other site
1215914006441	D-loop; other site
1215914006442	H-loop/switch region; other site
1215914006443	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1215914006444	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1215914006445	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914006446	Walker A/P-loop; other site
1215914006447	ATP binding site [chemical binding]; other site
1215914006448	Q-loop/lid; other site
1215914006449	ABC transporter signature motif; other site
1215914006450	Walker B; other site
1215914006451	D-loop; other site
1215914006452	H-loop/switch region; other site
1215914006453	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
1215914006454	trimer interface [polypeptide binding]; other site
1215914006455	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1215914006456	Transposase; Region: HTH_Tnp_1; pfam01527
1215914006457	HTH-like domain; Region: HTH_21; pfam13276
1215914006458	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1215914006459	Integrase core domain; Region: rve; pfam00665
1215914006460	Integrase core domain; Region: rve_3; pfam13683
1215914006461	CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd12218
1215914006462	CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866
1215914006463	tetramer interface [polypeptide binding]; other site
1215914006464	putative DNA binding site [nucleotide binding]; other site
1215914006465	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442
1215914006466	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
1215914006467	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
1215914006468	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
1215914006469	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
1215914006470	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
1215914006471	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1215914006472	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
1215914006473	Walker A/P-loop; other site
1215914006474	ATP binding site [chemical binding]; other site
1215914006475	Q-loop/lid; other site
1215914006476	ABC transporter signature motif; other site
1215914006477	Walker B; other site
1215914006478	D-loop; other site
1215914006479	H-loop/switch region; other site
1215914006480	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1215914006481	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1215914006482	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
1215914006483	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1215914006484	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
1215914006485	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1215914006486	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1215914006487	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
1215914006488	adenosine deaminase; Provisional; Region: PRK09358
1215914006489	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1215914006490	active site
1215914006491	Protein of unknown function (DUF460); Region: DUF460; pfam04312
1215914006492	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1215914006493	EamA-like transporter family; Region: EamA; pfam00892
1215914006494	EamA-like transporter family; Region: EamA; pfam00892
1215914006495	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1215914006496	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1215914006497	Ligand Binding Site [chemical binding]; other site
1215914006498	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1215914006499	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914006500	non-specific DNA binding site [nucleotide binding]; other site
1215914006501	salt bridge; other site
1215914006502	sequence-specific DNA binding site [nucleotide binding]; other site
1215914006503	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
1215914006504	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
1215914006505	epoxyqueuosine reductase; Region: TIGR00276
1215914006506	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1215914006507	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
1215914006508	protein binding surface [polypeptide binding]; other site
1215914006509	HEAT repeats; Region: HEAT_2; pfam13646
1215914006510	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1215914006511	Helix-turn-helix domain; Region: HTH_38; pfam13936
1215914006512	Integrase core domain; Region: rve; pfam00665
1215914006513	BioY family; Region: BioY; pfam02632
1215914006514	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1215914006515	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1215914006516	DNA binding residues [nucleotide binding]
1215914006517	putative dimer interface [polypeptide binding]; other site
1215914006518	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1215914006519	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
1215914006520	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1215914006521	catalytic Zn binding site [ion binding]; other site
1215914006522	NAD(P) binding site [chemical binding]; other site
1215914006523	structural Zn binding site [ion binding]; other site
1215914006524	atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267
1215914006525	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1215914006526	putative NAD(P) binding site [chemical binding]; other site
1215914006527	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1215914006528	S-adenosylmethionine binding site [chemical binding]; other site
1215914006529	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1215914006530	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1215914006531	catalytic triad [active]
1215914006532	Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021
1215914006533	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
1215914006534	Domain of unknown function DUF21; Region: DUF21; pfam01595
1215914006535	FOG: CBS domain [General function prediction only]; Region: COG0517
1215914006536	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1215914006537	Transporter associated domain; Region: CorC_HlyC; smart01091
1215914006538	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914006539	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1215914006540	Maf-like protein; Region: Maf; pfam02545
1215914006541	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1215914006542	active site
1215914006543	dimer interface [polypeptide binding]; other site
1215914006544	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1215914006545	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1215914006546	ATP binding site [chemical binding]; other site
1215914006547	Mg2+ binding site [ion binding]; other site
1215914006548	G-X-G motif; other site
1215914006549	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1215914006550	ATP binding site [chemical binding]; other site
1215914006551	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1215914006552	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1215914006553	MutS domain I; Region: MutS_I; pfam01624
1215914006554	MutS domain II; Region: MutS_II; pfam05188
1215914006555	MutS domain III; Region: MutS_III; pfam05192
1215914006556	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1215914006557	Walker A/P-loop; other site
1215914006558	ATP binding site [chemical binding]; other site
1215914006559	Q-loop/lid; other site
1215914006560	ABC transporter signature motif; other site
1215914006561	Walker B; other site
1215914006562	D-loop; other site
1215914006563	H-loop/switch region; other site
1215914006564	Amino acid permease; Region: AA_permease_2; pfam13520
1215914006565	Domain of unknown function (DUF1827); Region: DUF1827; pfam08860
1215914006566	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1215914006567	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1215914006568	ring oligomerisation interface [polypeptide binding]; other site
1215914006569	ATP/Mg binding site [chemical binding]; other site
1215914006570	stacking interactions; other site
1215914006571	hinge regions; other site
1215914006572	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1215914006573	oligomerisation interface [polypeptide binding]; other site
1215914006574	mobile loop; other site
1215914006575	roof hairpin; other site
1215914006576	CAAX protease self-immunity; Region: Abi; pfam02517
1215914006577	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1215914006578	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1215914006579	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1215914006580	Walker A/P-loop; other site
1215914006581	ATP binding site [chemical binding]; other site
1215914006582	Q-loop/lid; other site
1215914006583	ABC transporter signature motif; other site
1215914006584	Walker B; other site
1215914006585	D-loop; other site
1215914006586	H-loop/switch region; other site
1215914006587	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1215914006588	DNA-binding site [nucleotide binding]; DNA binding site
1215914006589	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
1215914006590	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1215914006591	CoA binding domain; Region: CoA_binding; pfam02629
1215914006592	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1215914006593	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914006594	Walker A/P-loop; other site
1215914006595	ATP binding site [chemical binding]; other site
1215914006596	Q-loop/lid; other site
1215914006597	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1215914006598	ABC transporter signature motif; other site
1215914006599	Walker B; other site
1215914006600	D-loop; other site
1215914006601	ABC transporter; Region: ABC_tran_2; pfam12848
1215914006602	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1215914006603	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1215914006604	active site
1215914006605	P-loop; other site
1215914006606	phosphorylation site [posttranslational modification]
1215914006607	UGMP family protein; Validated; Region: PRK09604
1215914006608	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1215914006609	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
1215914006610	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1215914006611	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1215914006612	Coenzyme A binding pocket [chemical binding]; other site
1215914006613	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1215914006614	Glycoprotease family; Region: Peptidase_M22; pfam00814
1215914006615	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1215914006616	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1215914006617	active site
1215914006618	homotetramer interface [polypeptide binding]; other site
1215914006619	homodimer interface [polypeptide binding]; other site
1215914006620	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
1215914006621	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1215914006622	active site
1215914006623	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1215914006624	active site 2 [active]
1215914006625	active site 1 [active]
1215914006626	Predicted methyltransferases [General function prediction only]; Region: COG0313
1215914006627	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1215914006628	putative SAM binding site [chemical binding]; other site
1215914006629	putative homodimer interface [polypeptide binding]; other site
1215914006630	DNA polymerase III subunit delta'; Validated; Region: PRK08058
1215914006631	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1215914006632	Protein of unknown function (DUF970); Region: DUF970; pfam06153
1215914006633	thymidylate kinase; Validated; Region: tmk; PRK00698
1215914006634	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1215914006635	TMP-binding site; other site
1215914006636	ATP-binding site [chemical binding]; other site
1215914006637	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
1215914006638	recombination protein RecR; Reviewed; Region: recR; PRK00076
1215914006639	RecR protein; Region: RecR; pfam02132
1215914006640	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1215914006641	putative active site [active]
1215914006642	putative metal-binding site [ion binding]; other site
1215914006643	tetramer interface [polypeptide binding]; other site
1215914006644	hypothetical protein; Validated; Region: PRK00153
1215914006645	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
1215914006646	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1215914006647	Walker A motif; other site
1215914006648	ATP binding site [chemical binding]; other site
1215914006649	Walker B motif; other site
1215914006650	arginine finger; other site
1215914006651	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1215914006652	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1215914006653	nucleoside/Zn binding site; other site
1215914006654	dimer interface [polypeptide binding]; other site
1215914006655	catalytic motif [active]
1215914006656	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1215914006657	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1215914006658	S-adenosylmethionine binding site [chemical binding]; other site
1215914006659	Predicted integral membrane protein [Function unknown]; Region: COG0392
1215914006660	Uncharacterized conserved protein [Function unknown]; Region: COG2898
1215914006661	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1215914006662	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1215914006663	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1215914006664	DNA binding site [nucleotide binding]
1215914006665	domain linker motif; other site
1215914006666	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
1215914006667	putative dimerization interface [polypeptide binding]; other site
1215914006668	putative ligand binding site [chemical binding]; other site
1215914006669	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
1215914006670	putative active site [active]
1215914006671	catalytic triad [active]
1215914006672	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
1215914006673	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
1215914006674	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
1215914006675	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
1215914006676	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1215914006677	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1215914006678	core dimer interface [polypeptide binding]; other site
1215914006679	peripheral dimer interface [polypeptide binding]; other site
1215914006680	L10 interface [polypeptide binding]; other site
1215914006681	L11 interface [polypeptide binding]; other site
1215914006682	putative EF-Tu interaction site [polypeptide binding]; other site
1215914006683	putative EF-G interaction site [polypeptide binding]; other site
1215914006684	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1215914006685	23S rRNA interface [nucleotide binding]; other site
1215914006686	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1215914006687	drug efflux system protein MdtG; Provisional; Region: PRK09874
1215914006688	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914006689	putative substrate translocation pore; other site
1215914006690	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914006691	putative substrate translocation pore; other site
1215914006692	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1215914006693	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
1215914006694	NAD(P) binding site [chemical binding]; other site
1215914006695	catalytic residues [active]
1215914006696	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1215914006697	mRNA/rRNA interface [nucleotide binding]; other site
1215914006698	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1215914006699	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1215914006700	23S rRNA interface [nucleotide binding]; other site
1215914006701	L7/L12 interface [polypeptide binding]; other site
1215914006702	putative thiostrepton binding site; other site
1215914006703	L25 interface [polypeptide binding]; other site
1215914006704	magnesium-transporting ATPase; Provisional; Region: PRK15122
1215914006705	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1215914006706	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1215914006707	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1215914006708	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1215914006709	motif II; other site
1215914006710	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1215914006711	amidase; Provisional; Region: PRK06529
1215914006712	Amidase; Region: Amidase; cl11426
1215914006713	Domain of unknown function (DU1801); Region: DUF1801; cl17490
1215914006714	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
1215914006715	ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505
1215914006716	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1215914006717	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
1215914006718	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
1215914006719	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1215914006720	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1215914006721	putative homodimer interface [polypeptide binding]; other site
1215914006722	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1215914006723	heterodimer interface [polypeptide binding]; other site
1215914006724	homodimer interface [polypeptide binding]; other site
1215914006725	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1215914006726	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
1215914006727	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
1215914006728	UbiA prenyltransferase family; Region: UbiA; pfam01040
1215914006729	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
1215914006730	UbiA prenyltransferase family; Region: UbiA; pfam01040
1215914006731	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
1215914006732	ApbE family; Region: ApbE; pfam02424
1215914006733	FMN-binding domain; Region: FMN_bind; cl01081
1215914006734	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
1215914006735	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1215914006736	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1215914006737	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1215914006738	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
1215914006739	trimer interface [polypeptide binding]; other site
1215914006740	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456
1215914006741	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1215914006742	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1215914006743	substrate binding pocket [chemical binding]; other site
1215914006744	chain length determination region; other site
1215914006745	substrate-Mg2+ binding site; other site
1215914006746	catalytic residues [active]
1215914006747	aspartate-rich region 1; other site
1215914006748	active site lid residues [active]
1215914006749	aspartate-rich region 2; other site
1215914006750	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
1215914006751	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1215914006752	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1215914006753	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1215914006754	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1215914006755	YacP-like NYN domain; Region: NYN_YacP; pfam05991
1215914006756	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
1215914006757	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1215914006758	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1215914006759	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1215914006760	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1215914006761	active site
1215914006762	HIGH motif; other site
1215914006763	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1215914006764	KMSKS motif; other site
1215914006765	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1215914006766	tRNA binding surface [nucleotide binding]; other site
1215914006767	anticodon binding site; other site
1215914006768	FAD binding domain; Region: FAD_binding_4; pfam01565
1215914006769	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
1215914006770	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1215914006771	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1215914006772	active site
1215914006773	HIGH motif; other site
1215914006774	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1215914006775	active site
1215914006776	KMSKS motif; other site
1215914006777	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1215914006778	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1215914006779	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1215914006780	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1215914006781	active site
1215914006782	dimer interface [polypeptide binding]; other site
1215914006783	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1215914006784	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1215914006785	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1215914006786	putative active site [active]
1215914006787	Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086
1215914006788	Predicted membrane protein [General function prediction only]; Region: COG4194
1215914006789	Predicted transcriptional regulators [Transcription]; Region: COG1725
1215914006790	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1215914006791	DNA-binding site [nucleotide binding]; DNA binding site
1215914006792	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1215914006793	putative DNA binding site [nucleotide binding]; other site
1215914006794	dimerization interface [polypeptide binding]; other site
1215914006795	putative Zn2+ binding site [ion binding]; other site
1215914006796	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914006797	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1215914006798	Walker A/P-loop; other site
1215914006799	ATP binding site [chemical binding]; other site
1215914006800	Q-loop/lid; other site
1215914006801	ABC transporter signature motif; other site
1215914006802	Walker B; other site
1215914006803	D-loop; other site
1215914006804	H-loop/switch region; other site
1215914006805	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1215914006806	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1215914006807	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1215914006808	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
1215914006809	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1215914006810	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1215914006811	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
1215914006812	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1215914006813	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1215914006814	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
1215914006815	Walker A/P-loop; other site
1215914006816	ATP binding site [chemical binding]; other site
1215914006817	Q-loop/lid; other site
1215914006818	ABC transporter signature motif; other site
1215914006819	Walker B; other site
1215914006820	D-loop; other site
1215914006821	H-loop/switch region; other site
1215914006822	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1215914006823	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914006824	non-specific DNA binding site [nucleotide binding]; other site
1215914006825	salt bridge; other site
1215914006826	sequence-specific DNA binding site [nucleotide binding]; other site
1215914006827	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
1215914006828	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
1215914006829	putative active site [active]
1215914006830	DNA repair protein RadA; Provisional; Region: PRK11823
1215914006831	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1215914006832	Walker A motif/ATP binding site; other site
1215914006833	ATP binding site [chemical binding]; other site
1215914006834	Walker B motif; other site
1215914006835	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1215914006836	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1215914006837	trimer interface [polypeptide binding]; other site
1215914006838	active site
1215914006839	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1215914006840	Coenzyme A binding pocket [chemical binding]; other site
1215914006841	Protein of unknown function (DUF805); Region: DUF805; pfam05656
1215914006842	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
1215914006843	trimer interface [polypeptide binding]; other site
1215914006844	active site
1215914006845	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
1215914006846	trimer interface [polypeptide binding]; other site
1215914006847	active site
1215914006848	G bulge; other site
1215914006849	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1215914006850	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914006851	Walker A/P-loop; other site
1215914006852	ATP binding site [chemical binding]; other site
1215914006853	Q-loop/lid; other site
1215914006854	ABC transporter signature motif; other site
1215914006855	Walker B; other site
1215914006856	D-loop; other site
1215914006857	H-loop/switch region; other site
1215914006858	K+ potassium transporter; Region: K_trans; pfam02705
1215914006859	pyruvate phosphate dikinase; Provisional; Region: PRK09279
1215914006860	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1215914006861	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1215914006862	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1215914006863	HTH domain; Region: HTH_11; pfam08279
1215914006864	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1215914006865	FOG: CBS domain [General function prediction only]; Region: COG0517
1215914006866	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1215914006867	catalytic core [active]
1215914006868	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
1215914006869	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
1215914006870	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
1215914006871	L-lactate oxidase; Region: L_lactate_ox; TIGR02708
1215914006872	L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2.  This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737
1215914006873	teramer interface [polypeptide binding]; other site
1215914006874	active site
1215914006875	FMN binding site [chemical binding]; other site
1215914006876	catalytic residues [active]
1215914006877	CsbD-like; Region: CsbD; pfam05532
1215914006878	phosphopentomutase; Provisional; Region: PRK05362
1215914006879	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1215914006880	benzoate transport; Region: 2A0115; TIGR00895
1215914006881	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914006882	putative substrate translocation pore; other site
1215914006883	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1215914006884	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1215914006885	benzoate transport; Region: 2A0115; TIGR00895
1215914006886	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914006887	putative substrate translocation pore; other site
1215914006888	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
1215914006889	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1215914006890	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914006891	H+ Antiporter protein; Region: 2A0121; TIGR00900
1215914006892	putative substrate translocation pore; other site
1215914006893	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1215914006894	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1215914006895	putative catalytic cysteine [active]
1215914006896	gamma-glutamyl kinase; Provisional; Region: PRK05429
1215914006897	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1215914006898	nucleotide binding site [chemical binding]; other site
1215914006899	homotetrameric interface [polypeptide binding]; other site
1215914006900	putative phosphate binding site [ion binding]; other site
1215914006901	putative allosteric binding site; other site
1215914006902	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
1215914006903	active site
1215914006904	catalytic site [active]
1215914006905	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
1215914006906	Cna protein B-type domain; Region: Cna_B; pfam05738
1215914006907	Cna protein B-type domain; Region: Cna_B; pfam05738
1215914006908	Cna protein B-type domain; Region: Cna_B; pfam05738
1215914006909	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
1215914006910	Uncharacterized conserved protein [Function unknown]; Region: COG3410
1215914006911	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
1215914006912	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1215914006913	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914006914	non-specific DNA binding site [nucleotide binding]; other site
1215914006915	salt bridge; other site
1215914006916	sequence-specific DNA binding site [nucleotide binding]; other site
1215914006917	Predicted transcriptional regulators [Transcription]; Region: COG1695
1215914006918	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1215914006919	Enterocin A Immunity; Region: EntA_Immun; pfam08951
1215914006920	Enterocin A Immunity; Region: EntA_Immun; pfam08951
1215914006921	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1215914006922	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1215914006923	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
1215914006924	bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000
1215914006925	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1215914006926	HlyD family secretion protein; Region: HlyD_3; pfam13437
1215914006927	ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193
1215914006928	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
1215914006929	putative active site [active]
1215914006930	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1215914006931	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914006932	Walker A/P-loop; other site
1215914006933	ATP binding site [chemical binding]; other site
1215914006934	Q-loop/lid; other site
1215914006935	ABC transporter signature motif; other site
1215914006936	Walker B; other site
1215914006937	D-loop; other site
1215914006938	H-loop/switch region; other site
1215914006939	sensory histidine kinase DcuS; Provisional; Region: PRK11086
1215914006940	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1215914006941	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1215914006942	active site
1215914006943	phosphorylation site [posttranslational modification]
1215914006944	intermolecular recognition site; other site
1215914006945	dimerization interface [polypeptide binding]; other site
1215914006946	LytTr DNA-binding domain; Region: LytTR; pfam04397
1215914006947	CAAX protease self-immunity; Region: Abi; pfam02517
1215914006948	CAAX protease self-immunity; Region: Abi; pfam02517
1215914006949	Enterocin A Immunity; Region: EntA_Immun; pfam08951
1215914006950	maltose O-acetyltransferase; Provisional; Region: PRK10092
1215914006951	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1215914006952	active site
1215914006953	substrate binding site [chemical binding]; other site
1215914006954	trimer interface [polypeptide binding]; other site
1215914006955	CoA binding site [chemical binding]; other site
1215914006956	Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439
1215914006957	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1215914006958	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1215914006959	active site
1215914006960	catalytic tetrad [active]
1215914006961	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1215914006962	classical (c) SDRs; Region: SDR_c; cd05233
1215914006963	NAD(P) binding site [chemical binding]; other site
1215914006964	active site
1215914006965	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
1215914006966	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1215914006967	putative active site [active]
1215914006968	putative FMN binding site [chemical binding]; other site
1215914006969	putative substrate binding site [chemical binding]; other site
1215914006970	putative catalytic residue [active]
1215914006971	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1215914006972	Class II fumarases; Region: Fumarase_classII; cd01362
1215914006973	active site
1215914006974	tetramer interface [polypeptide binding]; other site
1215914006975	manganese transport protein MntH; Reviewed; Region: PRK00701
1215914006976	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1215914006977	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1215914006978	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1215914006979	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1215914006980	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1215914006981	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1215914006982	motif II; other site
1215914006983	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1215914006984	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914006985	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1215914006986	putative substrate translocation pore; other site
1215914006987	multicopper oxidase; Provisional; Region: PRK10965
1215914006988	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1215914006989	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1215914006990	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1215914006991	Cation efflux family; Region: Cation_efflux; cl00316
1215914006992	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1215914006993	dimerization interface [polypeptide binding]; other site
1215914006994	putative DNA binding site [nucleotide binding]; other site
1215914006995	putative Zn2+ binding site [ion binding]; other site
1215914006996	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1215914006997	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
1215914006998	metal binding site [ion binding]; metal-binding site
1215914006999	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1215914007000	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1215914007001	Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088
1215914007002	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1215914007003	NAD binding site [chemical binding]; other site
1215914007004	catalytic residues [active]
1215914007005	substrate binding site [chemical binding]; other site
1215914007006	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1215914007007	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1215914007008	Helix-turn-helix domain; Region: HTH_38; pfam13936
1215914007009	Integrase core domain; Region: rve; pfam00665
1215914007010	Metal binding protein TroA_b.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020
1215914007011	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1215914007012	metal binding site [ion binding]; metal-binding site
1215914007013	atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267
1215914007014	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1215914007015	putative NAD(P) binding site [chemical binding]; other site
1215914007016	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
1215914007017	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
1215914007018	nudix motif; other site
1215914007019	Collagen binding domain; Region: Collagen_bind; pfam05737
1215914007020	Cna protein B-type domain; Region: Cna_B; pfam05738
1215914007021	Metal binding protein TroA_b.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020
1215914007022	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1215914007023	metal binding site [ion binding]; metal-binding site
1215914007024	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
1215914007025	SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320
1215914007026	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
1215914007027	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1215914007028	Walker A motif; other site
1215914007029	ATP binding site [chemical binding]; other site
1215914007030	Walker B motif; other site
1215914007031	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
1215914007032	Enolase, N-terminal domain; Region: Enolase_N; pfam03952
1215914007033	phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098
1215914007034	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1215914007035	membrane-bound complex binding site; other site
1215914007036	hinge residues; other site
1215914007037	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1215914007038	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1215914007039	Walker A/P-loop; other site
1215914007040	ATP binding site [chemical binding]; other site
1215914007041	Q-loop/lid; other site
1215914007042	ABC transporter signature motif; other site
1215914007043	Walker B; other site
1215914007044	D-loop; other site
1215914007045	H-loop/switch region; other site
1215914007046	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1215914007047	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914007048	dimer interface [polypeptide binding]; other site
1215914007049	conserved gate region; other site
1215914007050	putative PBP binding loops; other site
1215914007051	ABC-ATPase subunit interface; other site
1215914007052	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1215914007053	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914007054	dimer interface [polypeptide binding]; other site
1215914007055	conserved gate region; other site
1215914007056	putative PBP binding loops; other site
1215914007057	ABC-ATPase subunit interface; other site
1215914007058	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1215914007059	Helix-turn-helix domain; Region: HTH_38; pfam13936
1215914007060	Integrase core domain; Region: rve; pfam00665
1215914007061	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1215914007062	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1215914007063	substrate binding pocket [chemical binding]; other site
1215914007064	membrane-bound complex binding site; other site
1215914007065	hinge residues; other site
1215914007066	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1215914007067	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1215914007068	Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926
1215914007069	acyl-activating enzyme (AAE) consensus motif; other site
1215914007070	acyl-activating enzyme (AAE) consensus motif; other site
1215914007071	putative AMP binding site [chemical binding]; other site
1215914007072	putative active site [active]
1215914007073	putative CoA binding site [chemical binding]; other site
1215914007074	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1215914007075	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
1215914007076	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914007077	Walker A/P-loop; other site
1215914007078	ATP binding site [chemical binding]; other site
1215914007079	Q-loop/lid; other site
1215914007080	ABC transporter signature motif; other site
1215914007081	Walker B; other site
1215914007082	D-loop; other site
1215914007083	H-loop/switch region; other site
1215914007084	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1215914007085	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914007086	putative PBP binding loops; other site
1215914007087	dimer interface [polypeptide binding]; other site
1215914007088	ABC-ATPase subunit interface; other site
1215914007089	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1215914007090	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
1215914007091	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1215914007092	anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771
1215914007093	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914007094	Walker A/P-loop; other site
1215914007095	ATP binding site [chemical binding]; other site
1215914007096	Q-loop/lid; other site
1215914007097	ABC transporter signature motif; other site
1215914007098	Walker B; other site
1215914007099	D-loop; other site
1215914007100	H-loop/switch region; other site
1215914007101	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
1215914007102	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1215914007103	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1215914007104	23S rRNA interface [nucleotide binding]; other site
1215914007105	L3 interface [polypeptide binding]; other site
1215914007106	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1215914007107	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1215914007108	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1215914007109	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1215914007110	Walker A/P-loop; other site
1215914007111	ATP binding site [chemical binding]; other site
1215914007112	Q-loop/lid; other site
1215914007113	ABC transporter signature motif; other site
1215914007114	Walker B; other site
1215914007115	D-loop; other site
1215914007116	H-loop/switch region; other site
1215914007117	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1215914007118	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1215914007119	DNA binding residues [nucleotide binding]
1215914007120	dimer interface [polypeptide binding]; other site
1215914007121	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1215914007122	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1215914007123	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1215914007124	dimerization interface 3.5A [polypeptide binding]; other site
1215914007125	active site
1215914007126	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
1215914007127	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1215914007128	Walker A/P-loop; other site
1215914007129	ATP binding site [chemical binding]; other site
1215914007130	Q-loop/lid; other site
1215914007131	ABC transporter signature motif; other site
1215914007132	Walker B; other site
1215914007133	D-loop; other site
1215914007134	H-loop/switch region; other site
1215914007135	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
1215914007136	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1215914007137	Walker A/P-loop; other site
1215914007138	ATP binding site [chemical binding]; other site
1215914007139	Q-loop/lid; other site
1215914007140	ABC transporter signature motif; other site
1215914007141	Walker B; other site
1215914007142	D-loop; other site
1215914007143	H-loop/switch region; other site
1215914007144	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1215914007145	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1215914007146	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1215914007147	alphaNTD homodimer interface [polypeptide binding]; other site
1215914007148	alphaNTD - beta interaction site [polypeptide binding]; other site
1215914007149	alphaNTD - beta' interaction site [polypeptide binding]; other site
1215914007150	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1215914007151	30S ribosomal protein S11; Validated; Region: PRK05309
1215914007152	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1215914007153	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1215914007154	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
1215914007155	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1215914007156	rRNA binding site [nucleotide binding]; other site
1215914007157	predicted 30S ribosome binding site; other site
1215914007158	adenylate kinase; Reviewed; Region: adk; PRK00279
1215914007159	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1215914007160	AMP-binding site [chemical binding]; other site
1215914007161	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1215914007162	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1215914007163	SecY translocase; Region: SecY; pfam00344
1215914007164	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1215914007165	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1215914007166	23S rRNA binding site [nucleotide binding]; other site
1215914007167	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1215914007168	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1215914007169	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1215914007170	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1215914007171	5S rRNA interface [nucleotide binding]; other site
1215914007172	L27 interface [polypeptide binding]; other site
1215914007173	23S rRNA interface [nucleotide binding]; other site
1215914007174	L5 interface [polypeptide binding]; other site
1215914007175	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1215914007176	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1215914007177	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1215914007178	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1215914007179	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
1215914007180	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1215914007181	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1215914007182	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1215914007183	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1215914007184	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1215914007185	RNA binding site [nucleotide binding]; other site
1215914007186	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1215914007187	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1215914007188	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1215914007189	23S rRNA interface [nucleotide binding]; other site
1215914007190	putative translocon interaction site; other site
1215914007191	signal recognition particle (SRP54) interaction site; other site
1215914007192	L23 interface [polypeptide binding]; other site
1215914007193	trigger factor interaction site; other site
1215914007194	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1215914007195	23S rRNA interface [nucleotide binding]; other site
1215914007196	5S rRNA interface [nucleotide binding]; other site
1215914007197	putative antibiotic binding site [chemical binding]; other site
1215914007198	L25 interface [polypeptide binding]; other site
1215914007199	L27 interface [polypeptide binding]; other site
1215914007200	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1215914007201	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1215914007202	G-X-X-G motif; other site
1215914007203	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1215914007204	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1215914007205	putative translocon binding site; other site
1215914007206	protein-rRNA interface [nucleotide binding]; other site
1215914007207	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1215914007208	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1215914007209	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1215914007210	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1215914007211	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1215914007212	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1215914007213	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1215914007214	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1215914007215	phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833
1215914007216	peroxiredoxin; Region: AhpC; TIGR03137
1215914007217	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1215914007218	dimer interface [polypeptide binding]; other site
1215914007219	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1215914007220	catalytic triad [active]
1215914007221	peroxidatic and resolving cysteines [active]
1215914007222	Predicted transcriptional regulator [Transcription]; Region: COG2378
1215914007223	WYL domain; Region: WYL; pfam13280
1215914007224	elongation factor G; Reviewed; Region: PRK12739
1215914007225	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1215914007226	G1 box; other site
1215914007227	putative GEF interaction site [polypeptide binding]; other site
1215914007228	GTP/Mg2+ binding site [chemical binding]; other site
1215914007229	Switch I region; other site
1215914007230	G2 box; other site
1215914007231	G3 box; other site
1215914007232	Switch II region; other site
1215914007233	G4 box; other site
1215914007234	G5 box; other site
1215914007235	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1215914007236	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1215914007237	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1215914007238	30S ribosomal protein S7; Validated; Region: PRK05302
1215914007239	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1215914007240	S17 interaction site [polypeptide binding]; other site
1215914007241	S8 interaction site; other site
1215914007242	16S rRNA interaction site [nucleotide binding]; other site
1215914007243	streptomycin interaction site [chemical binding]; other site
1215914007244	23S rRNA interaction site [nucleotide binding]; other site
1215914007245	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1215914007246	Cna protein B-type domain; Region: Cna_B; pfam05738
1215914007247	Cna protein B-type domain; Region: Cna_B; pfam05738
1215914007248	Cna protein B-type domain; Region: Cna_B; pfam05738
1215914007249	Cna protein B-type domain; Region: Cna_B; pfam05738
1215914007250	Cna protein B-type domain; Region: Cna_B; pfam05738
1215914007251	Cna protein B-type domain; Region: Cna_B; pfam05738
1215914007252	Cna protein B-type domain; Region: Cna_B; pfam05738
1215914007253	Cna protein B-type domain; Region: Cna_B; pfam05738
1215914007254	Cna protein B-type domain; Region: Cna_B; pfam05738
1215914007255	Cna protein B-type domain; Region: Cna_B; pfam05738
1215914007256	Cna protein B-type domain; Region: Cna_B; pfam05738
1215914007257	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1215914007258	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1215914007259	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1215914007260	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1215914007261	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1215914007262	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1215914007263	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1215914007264	DNA binding site [nucleotide binding]
1215914007265	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1215914007266	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1215914007267	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1215914007268	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1215914007269	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1215914007270	RPB1 interaction site [polypeptide binding]; other site
1215914007271	RPB10 interaction site [polypeptide binding]; other site
1215914007272	RPB11 interaction site [polypeptide binding]; other site
1215914007273	RPB3 interaction site [polypeptide binding]; other site
1215914007274	RPB12 interaction site [polypeptide binding]; other site
1215914007275	Clp amino terminal domain; Region: Clp_N; pfam02861
1215914007276	Clp amino terminal domain; Region: Clp_N; pfam02861
1215914007277	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1215914007278	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1215914007279	Walker A motif; other site
1215914007280	ATP binding site [chemical binding]; other site
1215914007281	Walker B motif; other site
1215914007282	arginine finger; other site
1215914007283	UvrB/uvrC motif; Region: UVR; pfam02151
1215914007284	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
1215914007285	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1215914007286	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1215914007287	dimer interface [polypeptide binding]; other site
1215914007288	putative anticodon binding site; other site
1215914007289	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1215914007290	motif 1; other site
1215914007291	active site
1215914007292	motif 2; other site
1215914007293	motif 3; other site
1215914007294	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1215914007295	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1215914007296	FMN binding site [chemical binding]; other site
1215914007297	active site
1215914007298	catalytic residues [active]
1215914007299	substrate binding site [chemical binding]; other site
1215914007300	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1215914007301	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1215914007302	dimerization interface [polypeptide binding]; other site
1215914007303	domain crossover interface; other site
1215914007304	redox-dependent activation switch; other site
1215914007305	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
1215914007306	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
1215914007307	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
1215914007308	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
1215914007309	legume lectins; Region: lectin_L-type; cl14058
1215914007310	homotetramer interaction site [polypeptide binding]; other site
1215914007311	homodimer interaction site [polypeptide binding]; other site
1215914007312	carbohydrate binding site [chemical binding]; other site
1215914007313	metal binding site [ion binding]; metal-binding site
1215914007314	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
1215914007315	WxL domain surface cell wall-binding; Region: WxL; pfam13731
1215914007316	FtsH Extracellular; Region: FtsH_ext; pfam06480
1215914007317	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1215914007318	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1215914007319	Walker A motif; other site
1215914007320	ATP binding site [chemical binding]; other site
1215914007321	Walker B motif; other site
1215914007322	arginine finger; other site
1215914007323	Peptidase family M41; Region: Peptidase_M41; pfam01434
1215914007324	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1215914007325	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1215914007326	active site
1215914007327	TilS substrate C-terminal domain; Region: TilS_C; smart00977
1215914007328	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1215914007329	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1215914007330	Ligand Binding Site [chemical binding]; other site
1215914007331	hypothetical protein; Provisional; Region: PRK08582
1215914007332	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1215914007333	RNA binding site [nucleotide binding]; other site
1215914007334	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1215914007335	Septum formation initiator; Region: DivIC; pfam04977
1215914007336	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1215914007337	RNA binding surface [nucleotide binding]; other site
1215914007338	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1215914007339	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1215914007340	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1215914007341	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1215914007342	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1215914007343	ATP binding site [chemical binding]; other site
1215914007344	putative Mg++ binding site [ion binding]; other site
1215914007345	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1215914007346	nucleotide binding region [chemical binding]; other site
1215914007347	ATP-binding site [chemical binding]; other site
1215914007348	TRCF domain; Region: TRCF; pfam03461
1215914007349	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1215914007350	putative active site [active]
1215914007351	catalytic residue [active]
1215914007352	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1215914007353	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1215914007354	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1215914007355	NAD binding site [chemical binding]; other site
1215914007356	dimer interface [polypeptide binding]; other site
1215914007357	substrate binding site [chemical binding]; other site
1215914007358	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
1215914007359	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
1215914007360	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1215914007361	Predicted transcriptional regulators [Transcription]; Region: COG1695
1215914007362	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1215914007363	Predicted membrane protein [Function unknown]; Region: COG1511
1215914007364	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1215914007365	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1215914007366	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1215914007367	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1215914007368	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1215914007369	FOG: CBS domain [General function prediction only]; Region: COG0517
1215914007370	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1215914007371	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1215914007372	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
1215914007373	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1215914007374	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1215914007375	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1215914007376	active site
1215914007377	dimer interface [polypeptide binding]; other site
1215914007378	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1215914007379	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1215914007380	active site
1215914007381	FMN binding site [chemical binding]; other site
1215914007382	substrate binding site [chemical binding]; other site
1215914007383	3Fe-4S cluster binding site [ion binding]; other site
1215914007384	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1215914007385	domain interface; other site
1215914007386	QueT transporter; Region: QueT; pfam06177
1215914007387	PemK-like protein; Region: PemK; pfam02452
1215914007388	hypothetical protein; Region: PHA01623
1215914007389	alanine racemase; Reviewed; Region: alr; PRK00053
1215914007390	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1215914007391	active site
1215914007392	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1215914007393	dimer interface [polypeptide binding]; other site
1215914007394	substrate binding site [chemical binding]; other site
1215914007395	catalytic residues [active]
1215914007396	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1215914007397	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1215914007398	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1215914007399	ATP binding site [chemical binding]; other site
1215914007400	Mg++ binding site [ion binding]; other site
1215914007401	motif III; other site
1215914007402	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1215914007403	nucleotide binding region [chemical binding]; other site
1215914007404	ATP-binding site [chemical binding]; other site
1215914007405	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1215914007406	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1215914007407	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1215914007408	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1215914007409	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1215914007410	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1215914007411	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1215914007412	hinge; other site
1215914007413	active site
1215914007414	CTP synthetase; Validated; Region: pyrG; PRK05380
1215914007415	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1215914007416	Catalytic site [active]
1215914007417	active site
1215914007418	UTP binding site [chemical binding]; other site
1215914007419	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1215914007420	active site
1215914007421	putative oxyanion hole; other site
1215914007422	catalytic triad [active]
1215914007423	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
1215914007424	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
1215914007425	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
1215914007426	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1215914007427	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1215914007428	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1215914007429	Zn2+ binding site [ion binding]; other site
1215914007430	Mg2+ binding site [ion binding]; other site
1215914007431	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1215914007432	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1215914007433	putative active site [active]
1215914007434	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1215914007435	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
1215914007436	ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555
1215914007437	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1215914007438	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1215914007439	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1215914007440	active site
1215914007441	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
1215914007442	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1215914007443	Substrate binding site; other site
1215914007444	Mg++ binding site; other site
1215914007445	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1215914007446	active site
1215914007447	substrate binding site [chemical binding]; other site
1215914007448	CoA binding site [chemical binding]; other site
1215914007449	VanZ like family; Region: VanZ; pfam04892
1215914007450	RDD family; Region: RDD; pfam06271
1215914007451	pur operon repressor; Provisional; Region: PRK09213
1215914007452	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
1215914007453	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1215914007454	active site
1215914007455	putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247
1215914007456	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1215914007457	Walker A/P-loop; other site
1215914007458	ATP binding site [chemical binding]; other site
1215914007459	Q-loop/lid; other site
1215914007460	ABC transporter signature motif; other site
1215914007461	Walker B; other site
1215914007462	D-loop; other site
1215914007463	H-loop/switch region; other site
1215914007464	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
1215914007465	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1215914007466	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1215914007467	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
1215914007468	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1215914007469	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1215914007470	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
1215914007471	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1215914007472	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1215914007473	S-adenosylmethionine binding site [chemical binding]; other site
1215914007474	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
1215914007475	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1215914007476	putative active site [active]
1215914007477	putative metal binding site [ion binding]; other site
1215914007478	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
1215914007479	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1215914007480	active site
1215914007481	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
1215914007482	active site
1215914007483	phosphorylation site [posttranslational modification]
1215914007484	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
1215914007485	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
1215914007486	active site
1215914007487	catalytic residues [active]
1215914007488	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1215914007489	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1215914007490	active site
1215914007491	phosphorylation site [posttranslational modification]
1215914007492	intermolecular recognition site; other site
1215914007493	dimerization interface [polypeptide binding]; other site
1215914007494	LytTr DNA-binding domain; Region: LytTR; smart00850
1215914007495	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1215914007496	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1215914007497	ATP binding site [chemical binding]; other site
1215914007498	Mg2+ binding site [ion binding]; other site
1215914007499	G-X-G motif; other site
1215914007500	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1215914007501	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914007502	Walker A/P-loop; other site
1215914007503	ATP binding site [chemical binding]; other site
1215914007504	Q-loop/lid; other site
1215914007505	ABC transporter signature motif; other site
1215914007506	Walker B; other site
1215914007507	D-loop; other site
1215914007508	H-loop/switch region; other site
1215914007509	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1215914007510	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914007511	Walker A/P-loop; other site
1215914007512	ATP binding site [chemical binding]; other site
1215914007513	Q-loop/lid; other site
1215914007514	ABC transporter signature motif; other site
1215914007515	Walker B; other site
1215914007516	D-loop; other site
1215914007517	H-loop/switch region; other site
1215914007518	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
1215914007519	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1215914007520	active site
1215914007521	HIGH motif; other site
1215914007522	KMSKS motif; other site
1215914007523	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1215914007524	tRNA binding surface [nucleotide binding]; other site
1215914007525	anticodon binding site; other site
1215914007526	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1215914007527	dimer interface [polypeptide binding]; other site
1215914007528	putative tRNA-binding site [nucleotide binding]; other site
1215914007529	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
1215914007530	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1215914007531	Protein of unknown function DUF72; Region: DUF72; pfam01904
1215914007532	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
1215914007533	putative active site [active]
1215914007534	nucleotide binding site [chemical binding]; other site
1215914007535	nudix motif; other site
1215914007536	putative metal binding site [ion binding]; other site
1215914007537	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
1215914007538	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
1215914007539	LDH/MDH dimer interface [polypeptide binding]; other site
1215914007540	NAD(P) binding site [chemical binding]; other site
1215914007541	substrate binding site [chemical binding]; other site
1215914007542	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
1215914007543	NAD-dependent deacetylase; Provisional; Region: PRK00481
1215914007544	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
1215914007545	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1215914007546	substrate binding site [chemical binding]; other site
1215914007547	Predicted secreted protein [Function unknown]; Region: COG4086
1215914007548	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
1215914007549	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1215914007550	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1215914007551	polyphosphate kinase; Provisional; Region: PRK05443
1215914007552	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1215914007553	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1215914007554	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
1215914007555	putative domain interface [polypeptide binding]; other site
1215914007556	putative active site [active]
1215914007557	catalytic site [active]
1215914007558	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
1215914007559	putative domain interface [polypeptide binding]; other site
1215914007560	putative active site [active]
1215914007561	catalytic site [active]
1215914007562	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1215914007563	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1215914007564	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1215914007565	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1215914007566	active site
1215914007567	catalytic tetrad [active]
1215914007568	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1215914007569	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1215914007570	S-adenosylmethionine binding site [chemical binding]; other site
1215914007571	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1215914007572	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1215914007573	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1215914007574	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
1215914007575	Repair protein; Region: Repair_PSII; pfam04536
1215914007576	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
1215914007577	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1215914007578	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1215914007579	active site
1215914007580	HIGH motif; other site
1215914007581	dimer interface [polypeptide binding]; other site
1215914007582	KMSKS motif; other site
1215914007583	FtsX-like permease family; Region: FtsX; pfam02687
1215914007584	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1215914007585	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1215914007586	Walker A/P-loop; other site
1215914007587	ATP binding site [chemical binding]; other site
1215914007588	Q-loop/lid; other site
1215914007589	ABC transporter signature motif; other site
1215914007590	Walker B; other site
1215914007591	D-loop; other site
1215914007592	H-loop/switch region; other site
1215914007593	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
1215914007594	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1215914007595	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1215914007596	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1215914007597	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914007598	Walker A/P-loop; other site
1215914007599	ATP binding site [chemical binding]; other site
1215914007600	Q-loop/lid; other site
1215914007601	ABC transporter signature motif; other site
1215914007602	Walker B; other site
1215914007603	D-loop; other site
1215914007604	H-loop/switch region; other site
1215914007605	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914007606	conserved gate region; other site
1215914007607	ABC-ATPase subunit interface; other site
1215914007608	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1215914007609	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
1215914007610	Part of AAA domain; Region: AAA_19; pfam13245
1215914007611	Family description; Region: UvrD_C_2; pfam13538
1215914007612	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1215914007613	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1215914007614	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1215914007615	dimerization interface [polypeptide binding]; other site
1215914007616	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
1215914007617	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
1215914007618	gating phenylalanine in ion channel; other site
1215914007619	CAAX protease self-immunity; Region: Abi; pfam02517
1215914007620	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1215914007621	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
1215914007622	Zn2+ binding site [ion binding]; other site
1215914007623	Mg2+ binding site [ion binding]; other site
1215914007624	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1215914007625	MarR family; Region: MarR; pfam01047
1215914007626	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914007627	Walker A/P-loop; other site
1215914007628	ATP binding site [chemical binding]; other site
1215914007629	Q-loop/lid; other site
1215914007630	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1215914007631	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
1215914007632	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914007633	ABC transporter signature motif; other site
1215914007634	Walker B; other site
1215914007635	D-loop; other site
1215914007636	H-loop/switch region; other site
1215914007637	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914007638	Walker A/P-loop; other site
1215914007639	ATP binding site [chemical binding]; other site
1215914007640	Q-loop/lid; other site
1215914007641	ABC transporter signature motif; other site
1215914007642	Walker B; other site
1215914007643	D-loop; other site
1215914007644	H-loop/switch region; other site
1215914007645	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1215914007646	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1215914007647	active site
1215914007648	catalytic tetrad [active]
1215914007649	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1215914007650	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1215914007651	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
1215914007652	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1215914007653	catalytic core [active]
1215914007654	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
1215914007655	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1215914007656	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1215914007657	active site
1215914007658	motif I; other site
1215914007659	motif II; other site
1215914007660	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1215914007661	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1215914007662	RNA/DNA hybrid binding site [nucleotide binding]; other site
1215914007663	active site
1215914007664	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1215914007665	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1215914007666	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1215914007667	dimerization interface [polypeptide binding]; other site
1215914007668	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
1215914007669	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1215914007670	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1215914007671	homodimer interface [polypeptide binding]; other site
1215914007672	catalytic residue [active]
1215914007673	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1215914007674	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914007675	putative substrate translocation pore; other site
1215914007676	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1215914007677	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1215914007678	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1215914007679	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1215914007680	RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468
1215914007681	hexamer interface [polypeptide binding]; other site
1215914007682	Walker A motif; other site
1215914007683	ATP binding site [chemical binding]; other site
1215914007684	Walker B motif; other site
1215914007685	Protein of unknown function (DUF554); Region: DUF554; pfam04474
1215914007686	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
1215914007687	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1215914007688	active site
1215914007689	P-loop; other site
1215914007690	phosphorylation site [posttranslational modification]
1215914007691	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1215914007692	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1215914007693	active site
1215914007694	phosphorylation site [posttranslational modification]
1215914007695	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1215914007696	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1215914007697	putative substrate binding site [chemical binding]; other site
1215914007698	putative ATP binding site [chemical binding]; other site
1215914007699	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1215914007700	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1215914007701	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1215914007702	putative active site [active]
1215914007703	glycerol kinase; Provisional; Region: glpK; PRK00047
1215914007704	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1215914007705	N- and C-terminal domain interface [polypeptide binding]; other site
1215914007706	active site
1215914007707	MgATP binding site [chemical binding]; other site
1215914007708	catalytic site [active]
1215914007709	metal binding site [ion binding]; metal-binding site
1215914007710	glycerol binding site [chemical binding]; other site
1215914007711	homotetramer interface [polypeptide binding]; other site
1215914007712	homodimer interface [polypeptide binding]; other site
1215914007713	FBP binding site [chemical binding]; other site
1215914007714	protein IIAGlc interface [polypeptide binding]; other site
1215914007715	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1215914007716	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1215914007717	DNA-binding site [nucleotide binding]; DNA binding site
1215914007718	UTRA domain; Region: UTRA; cl17743
1215914007719	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
1215914007720	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
1215914007721	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1215914007722	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
1215914007723	active pocket/dimerization site; other site
1215914007724	active site
1215914007725	phosphorylation site [posttranslational modification]
1215914007726	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1215914007727	active site
1215914007728	phosphorylation site [posttranslational modification]
1215914007729	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
1215914007730	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
1215914007731	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1215914007732	active site
1215914007733	methionine cluster; other site
1215914007734	phosphorylation site [posttranslational modification]
1215914007735	metal binding site [ion binding]; metal-binding site
1215914007736	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1215914007737	active site
1215914007738	P-loop; other site
1215914007739	phosphorylation site [posttranslational modification]
1215914007740	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1215914007741	beta-galactosidase; Region: BGL; TIGR03356
1215914007742	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1215914007743	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1215914007744	nucleotide binding site [chemical binding]; other site
1215914007745	Uncharacterized conserved protein [Function unknown]; Region: COG3538
1215914007746	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
1215914007747	alpha-mannosidase; Provisional; Region: PRK09819
1215914007748	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
1215914007749	active site
1215914007750	metal binding site [ion binding]; metal-binding site
1215914007751	catalytic site [active]
1215914007752	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
1215914007753	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1215914007754	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1215914007755	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1215914007756	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1215914007757	DNA-binding site [nucleotide binding]; DNA binding site
1215914007758	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1215914007759	hypothetical protein; Provisional; Region: PRK06357
1215914007760	intersubunit interface [polypeptide binding]; other site
1215914007761	active site
1215914007762	Zn2+ binding site [ion binding]; other site
1215914007763	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
1215914007764	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
1215914007765	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
1215914007766	active site
1215914007767	P-loop; other site
1215914007768	phosphorylation site [posttranslational modification]
1215914007769	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1215914007770	active site
1215914007771	phosphorylation site [posttranslational modification]
1215914007772	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1215914007773	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1215914007774	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1215914007775	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1215914007776	S-adenosylmethionine binding site [chemical binding]; other site
1215914007777	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1215914007778	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1215914007779	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1215914007780	Ca binding site [ion binding]; other site
1215914007781	active site
1215914007782	catalytic site [active]
1215914007783	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1215914007784	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
1215914007785	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1215914007786	active pocket/dimerization site; other site
1215914007787	active site
1215914007788	phosphorylation site [posttranslational modification]
1215914007789	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
1215914007790	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
1215914007791	active site
1215914007792	phosphorylation site [posttranslational modification]
1215914007793	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
1215914007794	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1215914007795	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1215914007796	Bacterial transcriptional regulator; Region: IclR; pfam01614
1215914007797	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
1215914007798	2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935
1215914007799	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1215914007800	NADP binding site [chemical binding]; other site
1215914007801	homodimer interface [polypeptide binding]; other site
1215914007802	active site
1215914007803	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
1215914007804	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1215914007805	active site
1215914007806	intersubunit interface [polypeptide binding]; other site
1215914007807	catalytic residue [active]
1215914007808	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1215914007809	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1215914007810	substrate binding site [chemical binding]; other site
1215914007811	ATP binding site [chemical binding]; other site
1215914007812	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
1215914007813	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
1215914007814	active site
1215914007815	conserved hypothetical integral membrane protein; Region: TIGR03766
1215914007816	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1215914007817	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1215914007818	Ligand binding site; other site
1215914007819	Putative Catalytic site; other site
1215914007820	DXD motif; other site
1215914007821	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1215914007822	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1215914007823	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1215914007824	HAMP domain; Region: HAMP; pfam00672
1215914007825	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1215914007826	dimer interface [polypeptide binding]; other site
1215914007827	phosphorylation site [posttranslational modification]
1215914007828	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1215914007829	ATP binding site [chemical binding]; other site
1215914007830	Mg2+ binding site [ion binding]; other site
1215914007831	G-X-G motif; other site
1215914007832	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1215914007833	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1215914007834	active site
1215914007835	phosphorylation site [posttranslational modification]
1215914007836	intermolecular recognition site; other site
1215914007837	dimerization interface [polypeptide binding]; other site
1215914007838	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1215914007839	DNA binding site [nucleotide binding]
1215914007840	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1215914007841	Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298
1215914007842	NAD binding site [chemical binding]; other site
1215914007843	sugar binding site [chemical binding]; other site
1215914007844	divalent metal binding site [ion binding]; other site
1215914007845	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
1215914007846	dimer interface [polypeptide binding]; other site
1215914007847	bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110
1215914007848	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1215914007849	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1215914007850	active site turn [active]
1215914007851	phosphorylation site [posttranslational modification]
1215914007852	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
1215914007853	substrate binding site [chemical binding]; other site
1215914007854	catalytic residues [active]
1215914007855	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
1215914007856	Mga helix-turn-helix domain; Region: Mga; pfam05043
1215914007857	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1215914007858	Homeodomain-like domain; Region: HTH_23; cl17451
1215914007859	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1215914007860	Transposase; Region: HTH_Tnp_1; cl17663
1215914007861	Helix-turn-helix domain; Region: HTH_28; pfam13518
1215914007862	putative transposase OrfB; Reviewed; Region: PHA02517
1215914007863	HTH-like domain; Region: HTH_21; pfam13276
1215914007864	Integrase core domain; Region: rve; pfam00665
1215914007865	Integrase core domain; Region: rve_3; pfam13683
1215914007866	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1215914007867	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1215914007868	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1215914007869	putative active site [active]
1215914007870	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1215914007871	HPr interaction site; other site
1215914007872	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1215914007873	active site
1215914007874	phosphorylation site [posttranslational modification]
1215914007875	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1215914007876	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1215914007877	putative active site [active]
1215914007878	Protein of unknown function (DUF1341); Region: DUF1341; pfam07071
1215914007879	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1215914007880	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1215914007881	dihydroorotase; Provisional; Region: PRK09237
1215914007882	active site
1215914007883	Domain of unknown function (DUF4310); Region: DUF4310; pfam14187
1215914007884	Domain of unknown function (DUF4311); Region: DUF4311; cl11919
1215914007885	Domain of unknown function (DUF4312); Region: DUF4312; cl11917
1215914007886	Glycine-rich SFCGS; Region: Gly_rich_SFCGS; cl11916
1215914007887	PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582
1215914007888	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1215914007889	HTH domain; Region: HTH_11; pfam08279
1215914007890	HTH domain; Region: HTH_11; pfam08279
1215914007891	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1215914007892	active site
1215914007893	P-loop; other site
1215914007894	phosphorylation site [posttranslational modification]
1215914007895	Class I aldolases; Region: Aldolase_Class_I; cl17187
1215914007896	catalytic residue [active]
1215914007897	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829
1215914007898	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
1215914007899	PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825
1215914007900	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
1215914007901	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608
1215914007902	Glucitol operon activator protein (GutM); Region: GutM; pfam06923
1215914007903	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1215914007904	HTH domain; Region: HTH_11; pfam08279
1215914007905	PRD domain; Region: PRD; pfam00874
1215914007906	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
1215914007907	active site
1215914007908	phosphorylation site [posttranslational modification]
1215914007909	sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171
1215914007910	classical (c) SDRs; Region: SDR_c; cd05233
1215914007911	NAD(P) binding site [chemical binding]; other site
1215914007912	active site
1215914007913	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
1215914007914	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
1215914007915	intersubunit interface [polypeptide binding]; other site
1215914007916	active site
1215914007917	Zn2+ binding site [ion binding]; other site
1215914007918	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1215914007919	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1215914007920	active site
1215914007921	motif I; other site
1215914007922	motif II; other site
1215914007923	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1215914007924	motif II; other site
1215914007925	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
1215914007926	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1215914007927	AP (apurinic/apyrimidinic) site pocket; other site
1215914007928	DNA interaction; other site
1215914007929	Metal-binding active site; metal-binding site
1215914007930	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1215914007931	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1215914007932	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1215914007933	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
1215914007934	active site
1215914007935	dimer interface [polypeptide binding]; other site
1215914007936	magnesium binding site [ion binding]; other site
1215914007937	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1215914007938	active site
1215914007939	P-loop; other site
1215914007940	phosphorylation site [posttranslational modification]
1215914007941	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
1215914007942	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1215914007943	active site
1215914007944	phosphorylation site [posttranslational modification]
1215914007945	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
1215914007946	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1215914007947	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1215914007948	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1215914007949	active site
1215914007950	dimer interface [polypeptide binding]; other site
1215914007951	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1215914007952	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1215914007953	NAD(P) binding site [chemical binding]; other site
1215914007954	Class I aldolases; Region: Aldolase_Class_I; cl17187
1215914007955	catalytic residue [active]
1215914007956	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1215914007957	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1215914007958	substrate binding site [chemical binding]; other site
1215914007959	hexamer interface [polypeptide binding]; other site
1215914007960	metal binding site [ion binding]; metal-binding site
1215914007961	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
1215914007962	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
1215914007963	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
1215914007964	active site
1215914007965	phosphorylation site [posttranslational modification]
1215914007966	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1215914007967	active pocket/dimerization site; other site
1215914007968	active site
1215914007969	phosphorylation site [posttranslational modification]
1215914007970	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1215914007971	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1215914007972	NAD(P) binding site [chemical binding]; other site
1215914007973	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1215914007974	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1215914007975	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1215914007976	putative phosphoketolase; Provisional; Region: PRK05261
1215914007977	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
1215914007978	TPP-binding site; other site
1215914007979	XFP C-terminal domain; Region: XFP_C; pfam09363
1215914007980	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1215914007981	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1215914007982	nucleotide binding site [chemical binding]; other site
1215914007983	Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513
1215914007984	active site
1215914007985	dimer interface [polypeptide binding]; other site
1215914007986	catalytic nucleophile [active]
1215914007987	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1215914007988	dipeptidase, putative; Region: dipeptidaselike; TIGR01887
1215914007989	active site
1215914007990	metal binding site [ion binding]; metal-binding site
1215914007991	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1215914007992	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1215914007993	DNA-binding site [nucleotide binding]; DNA binding site
1215914007994	UTRA domain; Region: UTRA; pfam07702
1215914007995	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
1215914007996	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1215914007997	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1215914007998	homodimer interface [polypeptide binding]; other site
1215914007999	catalytic residue [active]
1215914008000	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914008001	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1215914008002	putative substrate translocation pore; other site
1215914008003	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
1215914008004	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
1215914008005	D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK; cd07803
1215914008006	N- and C-terminal domain interface [polypeptide binding]; other site
1215914008007	D-xylulose kinase; Region: XylB; TIGR01312
1215914008008	active site
1215914008009	MgATP binding site [chemical binding]; other site
1215914008010	catalytic site [active]
1215914008011	metal binding site [ion binding]; metal-binding site
1215914008012	xylulose binding site [chemical binding]; other site
1215914008013	homodimer interface [polypeptide binding]; other site
1215914008014	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1215914008015	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1215914008016	NAD(P) binding site [chemical binding]; other site
1215914008017	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
1215914008018	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
1215914008019	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
1215914008020	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
1215914008021	active site
1215914008022	phosphorylation site [posttranslational modification]
1215914008023	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1215914008024	active pocket/dimerization site; other site
1215914008025	active site
1215914008026	phosphorylation site [posttranslational modification]
1215914008027	PRD domain; Region: PRD; pfam00874
1215914008028	PRD domain; Region: PRD; pfam00874
1215914008029	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
1215914008030	active site
1215914008031	P-loop; other site
1215914008032	phosphorylation site [posttranslational modification]
1215914008033	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1215914008034	active site
1215914008035	phosphorylation site [posttranslational modification]
1215914008036	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1215914008037	Helix-turn-helix domain; Region: HTH_38; pfam13936
1215914008038	Integrase core domain; Region: rve; pfam00665
1215914008039	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1215914008040	intersubunit interface [polypeptide binding]; other site
1215914008041	active site
1215914008042	zinc binding site [ion binding]; other site
1215914008043	Na+ binding site [ion binding]; other site
1215914008044	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
1215914008045	uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774
1215914008046	putative N- and C-terminal domain interface [polypeptide binding]; other site
1215914008047	putative active site [active]
1215914008048	putative MgATP binding site [chemical binding]; other site
1215914008049	catalytic site [active]
1215914008050	metal binding site [ion binding]; metal-binding site
1215914008051	putative carbohydrate binding site [chemical binding]; other site
1215914008052	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
1215914008053	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
1215914008054	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
1215914008055	active site
1215914008056	P-loop; other site
1215914008057	phosphorylation site [posttranslational modification]
1215914008058	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1215914008059	active site
1215914008060	phosphorylation site [posttranslational modification]
1215914008061	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1215914008062	intersubunit interface [polypeptide binding]; other site
1215914008063	active site
1215914008064	zinc binding site [ion binding]; other site
1215914008065	Na+ binding site [ion binding]; other site
1215914008066	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1215914008067	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1215914008068	DNA-binding site [nucleotide binding]; DNA binding site
1215914008069	UTRA domain; Region: UTRA; pfam07702
1215914008070	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1215914008071	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1215914008072	Coenzyme A binding pocket [chemical binding]; other site
1215914008073	Predicted transcriptional regulators [Transcription]; Region: COG1695
1215914008074	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1215914008075	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914008076	D-galactonate transporter; Region: 2A0114; TIGR00893
1215914008077	putative substrate translocation pore; other site
1215914008078	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914008079	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1215914008080	Coenzyme A binding pocket [chemical binding]; other site
1215914008081	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1215914008082	Isochorismatase family; Region: Isochorismatase; pfam00857
1215914008083	catalytic triad [active]
1215914008084	conserved cis-peptide bond; other site
1215914008085	Protein of unknown function (DUF3923); Region: DUF3923; pfam13061
1215914008086	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1215914008087	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914008088	non-specific DNA binding site [nucleotide binding]; other site
1215914008089	salt bridge; other site
1215914008090	sequence-specific DNA binding site [nucleotide binding]; other site
1215914008091	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1215914008092	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1215914008093	active site
1215914008094	catalytic site [active]
1215914008095	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1215914008096	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1215914008097	active site
1215914008098	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1215914008099	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1215914008100	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1215914008101	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914008102	dimer interface [polypeptide binding]; other site
1215914008103	conserved gate region; other site
1215914008104	putative PBP binding loops; other site
1215914008105	ABC-ATPase subunit interface; other site
1215914008106	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1215914008107	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1215914008108	Walker A/P-loop; other site
1215914008109	ATP binding site [chemical binding]; other site
1215914008110	Q-loop/lid; other site
1215914008111	ABC transporter signature motif; other site
1215914008112	Walker B; other site
1215914008113	D-loop; other site
1215914008114	H-loop/switch region; other site
1215914008115	TOBE domain; Region: TOBE_2; pfam08402
1215914008116	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1215914008117	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1215914008118	active site
1215914008119	Isochorismatase family; Region: Isochorismatase; pfam00857
1215914008120	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1215914008121	catalytic triad [active]
1215914008122	conserved cis-peptide bond; other site
1215914008123	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
1215914008124	nudix motif; other site
1215914008125	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
1215914008126	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1215914008127	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
1215914008128	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
1215914008129	active site
1215914008130	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1215914008131	Beta-lactamase; Region: Beta-lactamase; pfam00144
1215914008132	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1215914008133	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1215914008134	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1215914008135	putative active site [active]
1215914008136	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
1215914008137	active site
1215914008138	phosphorylation site [posttranslational modification]
1215914008139	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
1215914008140	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1215914008141	putative phosphate binding site [ion binding]; other site
1215914008142	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1215914008143	DHH family; Region: DHH; pfam01368
1215914008144	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1215914008145	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1215914008146	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
1215914008147	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1215914008148	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
1215914008149	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1215914008150	Coenzyme A binding pocket [chemical binding]; other site
1215914008151	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
1215914008152	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1215914008153	active site
1215914008154	motif I; other site
1215914008155	motif II; other site
1215914008156	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1215914008157	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1215914008158	putative NAD(P) binding site [chemical binding]; other site
1215914008159	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
1215914008160	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
1215914008161	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
1215914008162	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1215914008163	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1215914008164	Coenzyme A binding pocket [chemical binding]; other site
1215914008165	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1215914008166	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1215914008167	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1215914008168	Coenzyme A binding pocket [chemical binding]; other site
1215914008169	Divergent AAA domain; Region: AAA_4; pfam04326
1215914008170	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1215914008171	Integrase core domain; Region: rve; pfam00665
1215914008172	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1215914008173	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1215914008174	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1215914008175	transmembrane helices; other site
1215914008176	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681
1215914008177	hypothetical protein; Provisional; Region: PRK06446
1215914008178	metal binding site [ion binding]; metal-binding site
1215914008179	dimer interface [polypeptide binding]; other site
1215914008180	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1215914008181	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1215914008182	peptide binding site [polypeptide binding]; other site
1215914008183	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
1215914008184	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1215914008185	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1215914008186	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1215914008187	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
1215914008188	putative dimer interface [polypeptide binding]; other site
1215914008189	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1215914008190	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1215914008191	protein binding site [polypeptide binding]; other site
1215914008192	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1215914008193	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1215914008194	YycH protein; Region: YycI; pfam09648
1215914008195	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1215914008196	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1215914008197	dimerization interface [polypeptide binding]; other site
1215914008198	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1215914008199	putative active site [active]
1215914008200	heme pocket [chemical binding]; other site
1215914008201	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1215914008202	dimer interface [polypeptide binding]; other site
1215914008203	phosphorylation site [posttranslational modification]
1215914008204	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1215914008205	ATP binding site [chemical binding]; other site
1215914008206	Mg2+ binding site [ion binding]; other site
1215914008207	G-X-G motif; other site
1215914008208	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1215914008209	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1215914008210	active site
1215914008211	phosphorylation site [posttranslational modification]
1215914008212	intermolecular recognition site; other site
1215914008213	dimerization interface [polypeptide binding]; other site
1215914008214	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1215914008215	DNA binding site [nucleotide binding]
1215914008216	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1215914008217	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1215914008218	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1215914008219	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1215914008220	substrate binding pocket [chemical binding]; other site
1215914008221	membrane-bound complex binding site; other site
1215914008222	hinge residues; other site
1215914008223	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1215914008224	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914008225	dimer interface [polypeptide binding]; other site
1215914008226	conserved gate region; other site
1215914008227	putative PBP binding loops; other site
1215914008228	ABC-ATPase subunit interface; other site
1215914008229	argininosuccinate synthase; Provisional; Region: PRK13820
1215914008230	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1215914008231	ANP binding site [chemical binding]; other site
1215914008232	Substrate Binding Site II [chemical binding]; other site
1215914008233	Substrate Binding Site I [chemical binding]; other site
1215914008234	argininosuccinate lyase; Provisional; Region: PRK00855
1215914008235	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1215914008236	active sites [active]
1215914008237	tetramer interface [polypeptide binding]; other site
1215914008238	Uncharacterized conserved protein [Function unknown]; Region: COG3589
1215914008239	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
1215914008240	Domain of unknown function (DUF3284); Region: DUF3284; pfam11687
1215914008241	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1215914008242	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1215914008243	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1215914008244	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1215914008245	DNA-binding site [nucleotide binding]; DNA binding site
1215914008246	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1215914008247	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1215914008248	active site
1215914008249	P-loop; other site
1215914008250	phosphorylation site [posttranslational modification]
1215914008251	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1215914008252	active site
1215914008253	methionine cluster; other site
1215914008254	phosphorylation site [posttranslational modification]
1215914008255	metal binding site [ion binding]; metal-binding site
1215914008256	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1215914008257	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1215914008258	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
1215914008259	nudix motif; other site
1215914008260	hypothetical protein; Provisional; Region: PRK06762
1215914008261	AAA domain; Region: AAA_33; pfam13671
1215914008262	Isochorismatase family; Region: Isochorismatase; pfam00857
1215914008263	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
1215914008264	catalytic triad [active]
1215914008265	dimer interface [polypeptide binding]; other site
1215914008266	conserved cis-peptide bond; other site
1215914008267	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914008268	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1215914008269	putative substrate translocation pore; other site
1215914008270	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914008271	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
1215914008272	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914008273	putative substrate translocation pore; other site
1215914008274	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1215914008275	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1215914008276	active site
1215914008277	catalytic tetrad [active]
1215914008278	Domain of unknown function (DUF956); Region: DUF956; pfam06115
1215914008279	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
1215914008280	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
1215914008281	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
1215914008282	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1215914008283	active pocket/dimerization site; other site
1215914008284	active site
1215914008285	phosphorylation site [posttranslational modification]
1215914008286	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1215914008287	active site
1215914008288	phosphorylation site [posttranslational modification]
1215914008289	H+ Antiporter protein; Region: 2A0121; TIGR00900
1215914008290	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1215914008291	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914008292	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1215914008293	non-specific DNA binding site [nucleotide binding]; other site
1215914008294	salt bridge; other site
1215914008295	sequence-specific DNA binding site [nucleotide binding]; other site
1215914008296	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
1215914008297	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1215914008298	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914008299	non-specific DNA binding site [nucleotide binding]; other site
1215914008300	salt bridge; other site
1215914008301	sequence-specific DNA binding site [nucleotide binding]; other site
1215914008302	Helix-turn-helix domain; Region: HTH_19; pfam12844
1215914008303	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
1215914008304	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1215914008305	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1215914008306	substrate binding pocket [chemical binding]; other site
1215914008307	membrane-bound complex binding site; other site
1215914008308	hinge residues; other site
1215914008309	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1215914008310	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914008311	dimer interface [polypeptide binding]; other site
1215914008312	conserved gate region; other site
1215914008313	putative PBP binding loops; other site
1215914008314	ABC-ATPase subunit interface; other site
1215914008315	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1215914008316	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1215914008317	Walker A/P-loop; other site
1215914008318	ATP binding site [chemical binding]; other site
1215914008319	Q-loop/lid; other site
1215914008320	ABC transporter signature motif; other site
1215914008321	Walker B; other site
1215914008322	D-loop; other site
1215914008323	H-loop/switch region; other site
1215914008324	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1215914008325	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1215914008326	Protein of unknown function (DUF975); Region: DUF975; cl10504
1215914008327	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918
1215914008328	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1215914008329	Uncharacterized conserved protein [Function unknown]; Region: COG3402
1215914008330	Predicted membrane protein [Function unknown]; Region: COG3428
1215914008331	Bacterial PH domain; Region: DUF304; pfam03703
1215914008332	Bacterial PH domain; Region: DUF304; pfam03703
1215914008333	Bacterial PH domain; Region: DUF304; cl01348
1215914008334	Predicted ATPase [General function prediction only]; Region: COG3910
1215914008335	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
1215914008336	Walker A/P-loop; other site
1215914008337	ATP binding site [chemical binding]; other site
1215914008338	Q-loop/lid; other site
1215914008339	ABC transporter signature motif; other site
1215914008340	Walker B; other site
1215914008341	D-loop; other site
1215914008342	H-loop/switch region; other site
1215914008343	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1215914008344	Phosphotransferase enzyme family; Region: APH; pfam01636
1215914008345	active site
1215914008346	ATP binding site [chemical binding]; other site
1215914008347	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1215914008348	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1215914008349	Walker A/P-loop; other site
1215914008350	ATP binding site [chemical binding]; other site
1215914008351	Q-loop/lid; other site
1215914008352	ABC transporter signature motif; other site
1215914008353	Walker B; other site
1215914008354	D-loop; other site
1215914008355	H-loop/switch region; other site
1215914008356	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1215914008357	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1215914008358	substrate binding pocket [chemical binding]; other site
1215914008359	membrane-bound complex binding site; other site
1215914008360	hinge residues; other site
1215914008361	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914008362	dimer interface [polypeptide binding]; other site
1215914008363	conserved gate region; other site
1215914008364	putative PBP binding loops; other site
1215914008365	ABC-ATPase subunit interface; other site
1215914008366	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1215914008367	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1215914008368	substrate binding pocket [chemical binding]; other site
1215914008369	membrane-bound complex binding site; other site
1215914008370	hinge residues; other site
1215914008371	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1215914008372	dimer interface [polypeptide binding]; other site
1215914008373	conserved gate region; other site
1215914008374	putative PBP binding loops; other site
1215914008375	ABC-ATPase subunit interface; other site
1215914008376	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1215914008377	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1215914008378	Integral membrane protein DUF95; Region: DUF95; pfam01944
1215914008379	MoxR-like ATPases [General function prediction only]; Region: COG0714
1215914008380	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1215914008381	Walker A motif; other site
1215914008382	ATP binding site [chemical binding]; other site
1215914008383	Walker B motif; other site
1215914008384	MoxR-like ATPases [General function prediction only]; Region: COG0714
1215914008385	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1215914008386	Protein of unknown function DUF58; Region: DUF58; pfam01882
1215914008387	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1215914008388	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1215914008389	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
1215914008390	putative ADP-binding pocket [chemical binding]; other site
1215914008391	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1215914008392	maltose O-acetyltransferase; Provisional; Region: PRK10092
1215914008393	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1215914008394	active site
1215914008395	substrate binding site [chemical binding]; other site
1215914008396	trimer interface [polypeptide binding]; other site
1215914008397	CoA binding site [chemical binding]; other site
1215914008398	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1215914008399	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1215914008400	active site
1215914008401	motif I; other site
1215914008402	motif II; other site
1215914008403	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1215914008404	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1215914008405	Aspartase; Region: Aspartase; cd01357
1215914008406	active sites [active]
1215914008407	tetramer interface [polypeptide binding]; other site
1215914008408	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
1215914008409	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1215914008410	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
1215914008411	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1215914008412	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1215914008413	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1215914008414	putative NAD(P) binding site [chemical binding]; other site
1215914008415	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
1215914008416	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1215914008417	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1215914008418	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1215914008419	active site
1215914008420	phosphorylation site [posttranslational modification]
1215914008421	intermolecular recognition site; other site
1215914008422	dimerization interface [polypeptide binding]; other site
1215914008423	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1215914008424	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1215914008425	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
1215914008426	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1215914008427	Agrin NtA domain; Region: NtA; pfam03146
1215914008428	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1215914008429	Int/Topo IB signature motif; other site
1215914008430	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1215914008431	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1215914008432	non-specific DNA binding site [nucleotide binding]; other site
1215914008433	salt bridge; other site
1215914008434	sequence-specific DNA binding site [nucleotide binding]; other site
1215914008435	Helix-turn-helix domain; Region: HTH_17; pfam12728
1215914008436	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
1215914008437	polymerase nucleotide-binding site; other site
1215914008438	DNA-binding residues [nucleotide binding]; DNA binding site
1215914008439	nucleotide binding site [chemical binding]; other site
1215914008440	primase nucleotide-binding site [nucleotide binding]; other site
1215914008441	Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942
1215914008442	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
1215914008443	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
1215914008444	HNH endonuclease; Region: HNH; pfam01844
1215914008445	active site
1215914008446	Phage terminase, small subunit; Region: Terminase_4; pfam05119
1215914008447	Phage Terminase; Region: Terminase_1; pfam03354
1215914008448	Phage portal protein; Region: Phage_portal; pfam04860
1215914008449	Phage-related protein [Function unknown]; Region: COG4695; cl01923
1215914008450	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
1215914008451	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
1215914008452	Phage capsid family; Region: Phage_capsid; pfam05065
1215914008453	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
1215914008454	oligomerization interface [polypeptide binding]; other site
1215914008455	Predicted membrane protein [Function unknown]; Region: COG2261
1215914008456	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1215914008457	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1215914008458	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1215914008459	active site
1215914008460	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1215914008461	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1215914008462	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1215914008463	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1215914008464	substrate binding pocket [chemical binding]; other site
1215914008465	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
1215914008466	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1215914008467	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1215914008468	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1215914008469	active site
1215914008470	phosphorylation site [posttranslational modification]
1215914008471	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1215914008472	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1215914008473	Mga helix-turn-helix domain; Region: Mga; pfam05043
1215914008474	DNA-binding interface [nucleotide binding]; DNA binding site
1215914008475	PRD domain; Region: PRD; pfam00874
1215914008476	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1215914008477	active site
1215914008478	P-loop; other site
1215914008479	phosphorylation site [posttranslational modification]
1215914008480	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
1215914008481	active site
1215914008482	phosphorylation site [posttranslational modification]
1215914008483	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
1215914008484	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
1215914008485	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1215914008486	active site
1215914008487	P-loop; other site
1215914008488	phosphorylation site [posttranslational modification]
1215914008489	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1215914008490	active site
1215914008491	P-loop; other site
1215914008492	phosphorylation site [posttranslational modification]
1215914008493	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1215914008494	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1215914008495	active site
1215914008496	trimer interface [polypeptide binding]; other site
1215914008497	allosteric site; other site
1215914008498	active site lid [active]
1215914008499	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1215914008500	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1215914008501	motif II; other site
1215914008502	HlyD family secretion protein; Region: HlyD_2; pfam12700
1215914008503	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1215914008504	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1215914008505	Walker A/P-loop; other site
1215914008506	ATP binding site [chemical binding]; other site
1215914008507	Q-loop/lid; other site
1215914008508	ABC transporter signature motif; other site
1215914008509	Walker B; other site
1215914008510	D-loop; other site
1215914008511	H-loop/switch region; other site
1215914008512	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1215914008513	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1215914008514	FtsX-like permease family; Region: FtsX; pfam02687
1215914008515	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1215914008516	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
1215914008517	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
1215914008518	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
1215914008519	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
1215914008520	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
1215914008521	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
1215914008522	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
1215914008523	putative active site [active]
1215914008524	metal binding site [ion binding]; metal-binding site
1215914008525	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1215914008526	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1215914008527	metal binding site [ion binding]; metal-binding site
1215914008528	dimer interface [polypeptide binding]; other site
1215914008529	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
1215914008530	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1215914008531	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1215914008532	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1215914008533	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
1215914008534	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1215914008535	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1215914008536	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1215914008537	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1215914008538	G1 box; other site
1215914008539	GTP/Mg2+ binding site [chemical binding]; other site
1215914008540	Switch I region; other site
1215914008541	G2 box; other site
1215914008542	Switch II region; other site
1215914008543	G3 box; other site
1215914008544	G4 box; other site
1215914008545	G5 box; other site
1215914008546	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1215914008547	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
1215914008548	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1215914008549	ribonuclease P; Reviewed; Region: rnpA; PRK00499
1215914008550	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
1215914008551	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
1215914008552	Toprim-like; Region: Toprim_2; pfam13155
1215914008553	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
1215914008554	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
1215914008555	Domain of unknown function (DUF955); Region: DUF955; cl01076
1215914008556	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1215914008557	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1215914008558	Peptidase family M23; Region: Peptidase_M23; pfam01551
1215914008559	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
1215914008560	Surface antigen [General function prediction only]; Region: COG3942
1215914008561	CHAP domain; Region: CHAP; pfam05257
1215914008562	AAA-like domain; Region: AAA_10; pfam12846
1215914008563	Domain of unknown function DUF87; Region: DUF87; pfam01935
1215914008564	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
1215914008565	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1215914008566	Walker A motif; other site
1215914008567	ATP binding site [chemical binding]; other site
1215914008568	Walker B motif; other site
1215914008569	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
1215914008570	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1215914008571	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1215914008572	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1215914008573	Integrase core domain; Region: rve; pfam00665
1215914008574	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
1215914008575	AIR carboxylase; Region: AIRC; smart01001
1215914008576	Protein of unknown function DUF111; Region: DUF111; cl03398
1215914008577	Protein of unknown function DUF111; Region: DUF111; cl03398
1215914008578	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
1215914008579	amphipathic channel; other site
1215914008580	Asn-Pro-Ala signature motifs; other site
1215914008581	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
1215914008582	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
1215914008583	Ligand Binding Site [chemical binding]; other site
1215914008584	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1215914008585	Integrase core domain; Region: rve; pfam00665
1215914008586	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
1215914008587	Pleckstrin homology-like domain; Region: PH-like; cl17171
1215914008588	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1215914008589	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1215914008590	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1215914008591	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1215914008592	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1215914008593	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1215914008594	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1215914008595	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1215914008596	ATP binding site [chemical binding]; other site
1215914008597	putative Mg++ binding site [ion binding]; other site
1215914008598	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1215914008599	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1215914008600	dimer interface [polypeptide binding]; other site
1215914008601	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1215914008602	catalytic residue [active]
1215914008603	cystathionine beta-lyase; Provisional; Region: PRK07671
1215914008604	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1215914008605	homodimer interface [polypeptide binding]; other site
1215914008606	substrate-cofactor binding pocket; other site
1215914008607	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1215914008608	catalytic residue [active]
1215914008609	serine O-acetyltransferase; Region: cysE; TIGR01172
1215914008610	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1215914008611	trimer interface [polypeptide binding]; other site
1215914008612	active site
1215914008613	substrate binding site [chemical binding]; other site
1215914008614	CoA binding site [chemical binding]; other site
1215914008615	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1215914008616	Dimer interface [polypeptide binding]; other site
1215914008617	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1215914008618	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1215914008619	catalytic residues [active]
1215914008620	catalytic nucleophile [active]
1215914008621	Presynaptic Site I dimer interface [polypeptide binding]; other site
1215914008622	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1215914008623	Synaptic Flat tetramer interface [polypeptide binding]; other site
1215914008624	Synaptic Site I dimer interface [polypeptide binding]; other site
1215914008625	DNA binding site [nucleotide binding]
1215914008626	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
1215914008627	HTH-like domain; Region: HTH_21; pfam13276
1215914008628	Integrase core domain; Region: rve; pfam00665
1215914008629	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1215914008630	Transposase; Region: HTH_Tnp_1; pfam01527
1215914008631	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
1215914008632	Collagen binding domain; Region: Collagen_bind; pfam05737
1215914008633	Collagen binding domain; Region: Collagen_bind; pfam05737
1215914008634	Collagen binding domain; Region: Collagen_bind; pfam05737
1215914008635	Collagen binding domain; Region: Collagen_bind; pfam05737
1215914008636	Cna protein B-type domain; Region: Cna_B; pfam05738
1215914008637	Cna protein B-type domain; Region: Cna_B; pfam05738
1215914008638	Cna protein B-type domain; Region: Cna_B; pfam05738
1215914008639	Cna protein B-type domain; Region: Cna_B; pfam05738
1215914008640	Cna protein B-type domain; Region: Cna_B; pfam05738
1215914008641	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1215914008642	Transposase; Region: HTH_Tnp_1; pfam01527
1215914008643	putative transposase OrfB; Reviewed; Region: PHA02517
1215914008644	HTH-like domain; Region: HTH_21; pfam13276
1215914008645	Integrase core domain; Region: rve; pfam00665
1215914008646	Integrase core domain; Region: rve_3; pfam13683
1215914008647	DNA polymerase IV; Reviewed; Region: PRK03103
1215914008648	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
1215914008649	active site
1215914008650	DNA binding site [nucleotide binding]
1215914008651	AAA domain; Region: AAA_31; pfam13614
1215914008652	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1215914008653	P-loop; other site
1215914008654	Magnesium ion binding site [ion binding]; other site
1215914008655	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1215914008656	Magnesium ion binding site [ion binding]; other site
1215914008657	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
1215914008658	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1215914008659	Integrase core domain; Region: rve; pfam00665