-- dump date 20140619_123118 -- class Genbank::misc_feature -- table misc_feature_note -- id note 748671000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 748671000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 748671000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748671000004 Walker A motif; other site 748671000005 ATP binding site [chemical binding]; other site 748671000006 Walker B motif; other site 748671000007 arginine finger; other site 748671000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 748671000009 DnaA box-binding interface [nucleotide binding]; other site 748671000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 748671000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 748671000012 putative DNA binding surface [nucleotide binding]; other site 748671000013 dimer interface [polypeptide binding]; other site 748671000014 beta-clamp/clamp loader binding surface; other site 748671000015 beta-clamp/translesion DNA polymerase binding surface; other site 748671000016 S4 domain; Region: S4_2; pfam13275 748671000017 recombination protein F; Reviewed; Region: recF; PRK00064 748671000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 748671000019 Walker A/P-loop; other site 748671000020 ATP binding site [chemical binding]; other site 748671000021 Q-loop/lid; other site 748671000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748671000023 ABC transporter signature motif; other site 748671000024 Walker B; other site 748671000025 D-loop; other site 748671000026 H-loop/switch region; other site 748671000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 748671000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748671000029 Mg2+ binding site [ion binding]; other site 748671000030 G-X-G motif; other site 748671000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 748671000032 anchoring element; other site 748671000033 dimer interface [polypeptide binding]; other site 748671000034 ATP binding site [chemical binding]; other site 748671000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 748671000036 active site 748671000037 putative metal-binding site [ion binding]; other site 748671000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 748671000039 DNA gyrase subunit A; Validated; Region: PRK05560 748671000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 748671000041 CAP-like domain; other site 748671000042 active site 748671000043 primary dimer interface [polypeptide binding]; other site 748671000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 748671000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 748671000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 748671000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 748671000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 748671000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 748671000050 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 748671000051 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 748671000052 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 748671000053 dimer interface [polypeptide binding]; other site 748671000054 ssDNA binding site [nucleotide binding]; other site 748671000055 tetramer (dimer of dimers) interface [polypeptide binding]; other site 748671000056 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 748671000057 Bacterial surface layer protein; Region: SLAP; pfam03217 748671000058 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 748671000059 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 748671000060 DHH family; Region: DHH; pfam01368 748671000061 DHHA1 domain; Region: DHHA1; pfam02272 748671000062 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 748671000063 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 748671000064 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 748671000065 replicative DNA helicase; Region: DnaB; TIGR00665 748671000066 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 748671000067 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 748671000068 Walker A motif; other site 748671000069 ATP binding site [chemical binding]; other site 748671000070 Walker B motif; other site 748671000071 DNA binding loops [nucleotide binding] 748671000072 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 748671000073 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 748671000074 substrate binding pocket [chemical binding]; other site 748671000075 membrane-bound complex binding site; other site 748671000076 hinge residues; other site 748671000077 EDD domain protein, DegV family; Region: DegV; TIGR00762 748671000078 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 748671000079 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 748671000080 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 748671000081 nucleotide binding site [chemical binding]; other site 748671000082 Predicted membrane protein [Function unknown]; Region: COG2261 748671000083 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 748671000084 MgtC family; Region: MgtC; pfam02308 748671000085 Predicted membrane protein [Function unknown]; Region: COG4905 748671000086 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 748671000087 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 748671000088 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 748671000089 MucBP domain; Region: MucBP; pfam06458 748671000090 MucBP domain; Region: MucBP; pfam06458 748671000091 MucBP domain; Region: MucBP; pfam06458 748671000092 Transposase; Region: DDE_Tnp_ISL3; pfam01610 748671000093 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 748671000094 Homeodomain-like domain; Region: HTH_23; cl17451 748671000095 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 748671000096 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 748671000097 peptide binding site [polypeptide binding]; other site 748671000098 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 748671000099 Domain of unknown function DUF20; Region: UPF0118; pfam01594 748671000100 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 748671000101 catalytic triad [active] 748671000102 oxyanion hole [active] 748671000103 active site 748671000104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748671000105 putative substrate translocation pore; other site 748671000106 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748671000107 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 748671000108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748671000109 Walker A/P-loop; other site 748671000110 ATP binding site [chemical binding]; other site 748671000111 Q-loop/lid; other site 748671000112 ABC transporter signature motif; other site 748671000113 Walker B; other site 748671000114 D-loop; other site 748671000115 H-loop/switch region; other site 748671000116 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 748671000117 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 748671000118 TM-ABC transporter signature motif; other site 748671000119 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 748671000120 zinc binding site [ion binding]; other site 748671000121 putative ligand binding site [chemical binding]; other site 748671000122 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748671000123 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748671000124 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748671000125 Walker A/P-loop; other site 748671000126 ATP binding site [chemical binding]; other site 748671000127 Q-loop/lid; other site 748671000128 ABC transporter signature motif; other site 748671000129 Walker B; other site 748671000130 D-loop; other site 748671000131 H-loop/switch region; other site 748671000132 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748671000133 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748671000134 non-specific DNA binding site [nucleotide binding]; other site 748671000135 salt bridge; other site 748671000136 sequence-specific DNA binding site [nucleotide binding]; other site 748671000137 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748671000138 motif II; other site 748671000139 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 748671000140 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 748671000141 oligomer interface [polypeptide binding]; other site 748671000142 Cl binding site [ion binding]; other site 748671000143 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 748671000144 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 748671000145 active site 748671000146 catalytic tetrad [active] 748671000147 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748671000148 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748671000149 non-specific DNA binding site [nucleotide binding]; other site 748671000150 salt bridge; other site 748671000151 sequence-specific DNA binding site [nucleotide binding]; other site 748671000152 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 748671000153 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 748671000154 G1 box; other site 748671000155 putative GEF interaction site [polypeptide binding]; other site 748671000156 GTP/Mg2+ binding site [chemical binding]; other site 748671000157 Switch I region; other site 748671000158 G2 box; other site 748671000159 G3 box; other site 748671000160 Switch II region; other site 748671000161 G4 box; other site 748671000162 G5 box; other site 748671000163 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 748671000164 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 748671000165 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 748671000166 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748671000167 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 748671000168 active site 748671000169 motif I; other site 748671000170 motif II; other site 748671000171 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 748671000172 D-lactate dehydrogenase; Validated; Region: PRK08605 748671000173 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 748671000174 homodimer interface [polypeptide binding]; other site 748671000175 ligand binding site [chemical binding]; other site 748671000176 NAD binding site [chemical binding]; other site 748671000177 catalytic site [active] 748671000178 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 748671000179 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 748671000180 active site 748671000181 putative catalytic site [active] 748671000182 DNA binding site [nucleotide binding] 748671000183 putative phosphate binding site [ion binding]; other site 748671000184 metal binding site A [ion binding]; metal-binding site 748671000185 AP binding site [nucleotide binding]; other site 748671000186 metal binding site B [ion binding]; metal-binding site 748671000187 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 748671000188 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 748671000189 PLD-like domain; Region: PLDc_2; pfam13091 748671000190 putative homodimer interface [polypeptide binding]; other site 748671000191 putative active site [active] 748671000192 catalytic site [active] 748671000193 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 748671000194 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748671000195 ATP binding site [chemical binding]; other site 748671000196 putative Mg++ binding site [ion binding]; other site 748671000197 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748671000198 nucleotide binding region [chemical binding]; other site 748671000199 ATP-binding site [chemical binding]; other site 748671000200 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 748671000201 Beta-lactamase; Region: Beta-lactamase; pfam00144 748671000202 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 748671000203 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 748671000204 AAA ATPase domain; Region: AAA_16; pfam13191 748671000205 Uncharacterized conserved protein [Function unknown]; Region: COG3410 748671000206 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 748671000207 active site 748671000208 catalytic residues [active] 748671000209 metal binding site [ion binding]; metal-binding site 748671000210 Domain of unknown function (DUF4323); Region: DUF4323; pfam14211 748671000211 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 748671000212 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 748671000213 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 748671000214 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 748671000215 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 748671000216 putative acyl-acceptor binding pocket; other site 748671000217 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 748671000218 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 748671000219 Ligand binding site; other site 748671000220 metal-binding site 748671000221 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 748671000222 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 748671000223 Ligand binding site; other site 748671000224 metal-binding site 748671000225 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 748671000226 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 748671000227 active site 748671000228 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 748671000229 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 748671000230 putative acyl-acceptor binding pocket; other site 748671000231 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748671000232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748671000233 active site 748671000234 phosphorylation site [posttranslational modification] 748671000235 intermolecular recognition site; other site 748671000236 dimerization interface [polypeptide binding]; other site 748671000237 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748671000238 DNA binding site [nucleotide binding] 748671000239 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 748671000240 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748671000241 dimerization interface [polypeptide binding]; other site 748671000242 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 748671000243 putative active site [active] 748671000244 heme pocket [chemical binding]; other site 748671000245 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748671000246 dimer interface [polypeptide binding]; other site 748671000247 phosphorylation site [posttranslational modification] 748671000248 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748671000249 ATP binding site [chemical binding]; other site 748671000250 Mg2+ binding site [ion binding]; other site 748671000251 G-X-G motif; other site 748671000252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 748671000253 YycH protein; Region: YycH; pfam07435 748671000254 YycH protein; Region: YycI; pfam09648 748671000255 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 748671000256 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 748671000257 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 748671000258 protein binding site [polypeptide binding]; other site 748671000259 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 748671000260 Bacterial surface layer protein; Region: SLAP; pfam03217 748671000261 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 748671000262 putative active site [active] 748671000263 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 748671000264 Cobalt transport protein; Region: CbiQ; cl00463 748671000265 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 748671000266 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 748671000267 Walker A/P-loop; other site 748671000268 ATP binding site [chemical binding]; other site 748671000269 Q-loop/lid; other site 748671000270 ABC transporter signature motif; other site 748671000271 Walker B; other site 748671000272 D-loop; other site 748671000273 H-loop/switch region; other site 748671000274 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 748671000275 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748671000276 Walker A/P-loop; other site 748671000277 ATP binding site [chemical binding]; other site 748671000278 Q-loop/lid; other site 748671000279 ABC transporter signature motif; other site 748671000280 Walker B; other site 748671000281 D-loop; other site 748671000282 H-loop/switch region; other site 748671000283 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 748671000284 Helix-turn-helix domain; Region: HTH_18; pfam12833 748671000285 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 748671000286 heat shock protein HtpX; Provisional; Region: PRK04897 748671000287 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 748671000288 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 748671000289 transmembrane helices; other site 748671000290 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 748671000291 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 748671000292 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 748671000293 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 748671000294 putative active site [active] 748671000295 catalytic site [active] 748671000296 putative metal binding site [ion binding]; other site 748671000297 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 748671000298 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 748671000299 DXD motif; other site 748671000300 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 748671000301 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 748671000302 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748671000303 Zn2+ binding site [ion binding]; other site 748671000304 Mg2+ binding site [ion binding]; other site 748671000305 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 748671000306 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 748671000307 active site 748671000308 Protein of unknown function (DUF805); Region: DUF805; pfam05656 748671000309 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 748671000310 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 748671000311 Walker A/P-loop; other site 748671000312 ATP binding site [chemical binding]; other site 748671000313 Q-loop/lid; other site 748671000314 ABC transporter signature motif; other site 748671000315 Walker B; other site 748671000316 D-loop; other site 748671000317 H-loop/switch region; other site 748671000318 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 748671000319 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 748671000320 substrate binding pocket [chemical binding]; other site 748671000321 membrane-bound complex binding site; other site 748671000322 hinge residues; other site 748671000323 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 748671000324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748671000325 dimer interface [polypeptide binding]; other site 748671000326 conserved gate region; other site 748671000327 putative PBP binding loops; other site 748671000328 ABC-ATPase subunit interface; other site 748671000329 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 748671000330 active site 748671000331 DNA binding site [nucleotide binding] 748671000332 Protein of unknown function, DUF488; Region: DUF488; cl01246 748671000333 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 748671000334 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 748671000335 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 748671000336 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 748671000337 DNA binding site [nucleotide binding] 748671000338 active site 748671000339 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 748671000340 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 748671000341 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 748671000342 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 748671000343 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 748671000344 putative active site [active] 748671000345 catalytic site [active] 748671000346 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 748671000347 putative active site [active] 748671000348 catalytic site [active] 748671000349 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 748671000350 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 748671000351 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 748671000352 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 748671000353 RNA/DNA hybrid binding site [nucleotide binding]; other site 748671000354 active site 748671000355 Predicted secreted protein [Function unknown]; Region: COG4086 748671000356 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 748671000357 putative glycosyl transferase; Provisional; Region: PRK10073 748671000358 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 748671000359 active site 748671000360 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 748671000361 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 748671000362 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748671000363 non-specific DNA binding site [nucleotide binding]; other site 748671000364 salt bridge; other site 748671000365 sequence-specific DNA binding site [nucleotide binding]; other site 748671000366 YcaO-like family; Region: YcaO; pfam02624 748671000367 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748671000368 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 748671000369 putative FMN binding site [chemical binding]; other site 748671000370 NADPH bind site [chemical binding]; other site 748671000371 Transposase, Mutator family; Region: Transposase_mut; pfam00872 748671000372 MULE transposase domain; Region: MULE; pfam10551 748671000373 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 748671000374 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 748671000375 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 748671000376 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748671000377 active site 748671000378 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748671000379 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 748671000380 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 748671000381 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 748671000382 substrate binding pocket [chemical binding]; other site 748671000383 membrane-bound complex binding site; other site 748671000384 hinge residues; other site 748671000385 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 748671000386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748671000387 dimer interface [polypeptide binding]; other site 748671000388 conserved gate region; other site 748671000389 putative PBP binding loops; other site 748671000390 ABC-ATPase subunit interface; other site 748671000391 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 748671000392 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 748671000393 Walker A/P-loop; other site 748671000394 ATP binding site [chemical binding]; other site 748671000395 Q-loop/lid; other site 748671000396 ABC transporter signature motif; other site 748671000397 Walker B; other site 748671000398 D-loop; other site 748671000399 H-loop/switch region; other site 748671000400 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 748671000401 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 748671000402 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 748671000403 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 748671000404 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 748671000405 DNA binding residues [nucleotide binding] 748671000406 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 748671000407 YibE/F-like protein; Region: YibE_F; pfam07907 748671000408 YibE/F-like protein; Region: YibE_F; pfam07907 748671000409 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 748671000410 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 748671000411 active site 748671000412 catalytic site [active] 748671000413 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 748671000414 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 748671000415 Interdomain contacts; other site 748671000416 Cytokine receptor motif; other site 748671000417 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 748671000418 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 748671000419 active site 748671000420 dimer interface [polypeptide binding]; other site 748671000421 Transposase, Mutator family; Region: Transposase_mut; pfam00872 748671000422 MULE transposase domain; Region: MULE; pfam10551 748671000423 RelB antitoxin; Region: RelB; cl01171 748671000424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 748671000425 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 748671000426 AAA domain; Region: AAA_14; pfam13173 748671000427 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 748671000428 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 748671000429 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 748671000430 active site 748671000431 phosphorylation site [posttranslational modification] 748671000432 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 748671000433 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 748671000434 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 748671000435 Ligand Binding Site [chemical binding]; other site 748671000436 Helix-turn-helix domain; Region: HTH_38; pfam13936 748671000437 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 748671000438 DNA-binding interface [nucleotide binding]; DNA binding site 748671000439 Integrase core domain; Region: rve; pfam00665 748671000440 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 748671000441 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 748671000442 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 748671000443 membrane-bound complex binding site; other site 748671000444 hinge residues; other site 748671000445 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 748671000446 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 748671000447 Walker A/P-loop; other site 748671000448 ATP binding site [chemical binding]; other site 748671000449 Q-loop/lid; other site 748671000450 ABC transporter signature motif; other site 748671000451 Walker B; other site 748671000452 D-loop; other site 748671000453 H-loop/switch region; other site 748671000454 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 748671000455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748671000456 dimer interface [polypeptide binding]; other site 748671000457 conserved gate region; other site 748671000458 putative PBP binding loops; other site 748671000459 ABC-ATPase subunit interface; other site 748671000460 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 748671000461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748671000462 dimer interface [polypeptide binding]; other site 748671000463 conserved gate region; other site 748671000464 putative PBP binding loops; other site 748671000465 ABC-ATPase subunit interface; other site 748671000466 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 748671000467 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 748671000468 active site 748671000469 metal binding site [ion binding]; metal-binding site 748671000470 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 748671000471 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 748671000472 active site 748671000473 dimer interface [polypeptide binding]; other site 748671000474 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 748671000475 Ligand Binding Site [chemical binding]; other site 748671000476 Molecular Tunnel; other site 748671000477 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 748671000478 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 748671000479 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 748671000480 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 748671000481 ATP cone domain; Region: ATP-cone; pfam03477 748671000482 Class III ribonucleotide reductase; Region: RNR_III; cd01675 748671000483 effector binding site; other site 748671000484 active site 748671000485 Zn binding site [ion binding]; other site 748671000486 glycine loop; other site 748671000487 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 748671000488 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 748671000489 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 748671000490 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 748671000491 Uncharacterized conserved protein [Function unknown]; Region: COG2461 748671000492 Family of unknown function (DUF438); Region: DUF438; pfam04282 748671000493 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 748671000494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748671000495 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748671000496 putative substrate translocation pore; other site 748671000497 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 748671000498 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 748671000499 active site 748671000500 Zn binding site [ion binding]; other site 748671000501 K+ potassium transporter; Region: K_trans; pfam02705 748671000502 CRISPR type AFERR-associated DEAD/DEAH-box helicase Csf4; Region: cas_csf4; TIGR03117 748671000503 PemK-like protein; Region: PemK; pfam02452 748671000504 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 748671000505 Bacterial surface layer protein; Region: SLAP; pfam03217 748671000506 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 748671000507 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 748671000508 RNA polymerase factor sigma-70; Validated; Region: PRK06759 748671000509 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 748671000510 Bacterial surface layer protein; Region: SLAP; pfam03217 748671000511 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 748671000512 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 748671000513 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 748671000514 Cadmium resistance transporter; Region: Cad; pfam03596 748671000515 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 748671000516 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 748671000517 Bacterial surface layer protein; Region: SLAP; pfam03217 748671000518 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 748671000519 amidase catalytic site [active] 748671000520 Zn binding residues [ion binding]; other site 748671000521 substrate binding site [chemical binding]; other site 748671000522 Bacterial surface layer protein; Region: SLAP; pfam03217 748671000523 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 748671000524 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 748671000525 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 748671000526 TrkA-N domain; Region: TrkA_N; pfam02254 748671000527 TrkA-C domain; Region: TrkA_C; pfam02080 748671000528 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 748671000529 putative substrate binding pocket [chemical binding]; other site 748671000530 AC domain interface; other site 748671000531 catalytic triad [active] 748671000532 AB domain interface; other site 748671000533 interchain disulfide; other site 748671000534 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 748671000535 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 748671000536 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 748671000537 catalytic core [active] 748671000538 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 748671000539 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 748671000540 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 748671000541 membrane protein; Provisional; Region: PRK14411 748671000542 Sulfatase; Region: Sulfatase; cl17466 748671000543 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 748671000544 Interdomain contacts; other site 748671000545 Cytokine receptor motif; other site 748671000546 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 748671000547 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 748671000548 active site 748671000549 HIGH motif; other site 748671000550 dimer interface [polypeptide binding]; other site 748671000551 KMSKS motif; other site 748671000552 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 748671000553 RNA binding surface [nucleotide binding]; other site 748671000554 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 748671000555 trimer interface [polypeptide binding]; other site 748671000556 active site 748671000557 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 748671000558 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 748671000559 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 748671000560 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 748671000561 peptide binding site [polypeptide binding]; other site 748671000562 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 748671000563 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 748671000564 peptide binding site [polypeptide binding]; other site 748671000565 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 748671000566 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 748671000567 active site 748671000568 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 748671000569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748671000570 dimer interface [polypeptide binding]; other site 748671000571 conserved gate region; other site 748671000572 putative PBP binding loops; other site 748671000573 ABC-ATPase subunit interface; other site 748671000574 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 748671000575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748671000576 dimer interface [polypeptide binding]; other site 748671000577 conserved gate region; other site 748671000578 putative PBP binding loops; other site 748671000579 ABC-ATPase subunit interface; other site 748671000580 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 748671000581 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 748671000582 Walker A/P-loop; other site 748671000583 ATP binding site [chemical binding]; other site 748671000584 Q-loop/lid; other site 748671000585 ABC transporter signature motif; other site 748671000586 Walker B; other site 748671000587 D-loop; other site 748671000588 H-loop/switch region; other site 748671000589 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 748671000590 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 748671000591 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 748671000592 Walker A/P-loop; other site 748671000593 ATP binding site [chemical binding]; other site 748671000594 Q-loop/lid; other site 748671000595 ABC transporter signature motif; other site 748671000596 Walker B; other site 748671000597 D-loop; other site 748671000598 H-loop/switch region; other site 748671000599 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 748671000600 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 748671000601 trimer interface [polypeptide binding]; other site 748671000602 active site 748671000603 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 748671000604 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 748671000605 putative dimer interface [polypeptide binding]; other site 748671000606 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 748671000607 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 748671000608 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 748671000609 CAAX protease self-immunity; Region: Abi; pfam02517 748671000610 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 748671000611 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 748671000612 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 748671000613 active site 748671000614 HIGH motif; other site 748671000615 dimer interface [polypeptide binding]; other site 748671000616 KMSKS motif; other site 748671000617 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 748671000618 catalytic motif [active] 748671000619 Zn binding site [ion binding]; other site 748671000620 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 748671000621 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 748671000622 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 748671000623 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 748671000624 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 748671000625 Soluble P-type ATPase [General function prediction only]; Region: COG4087 748671000626 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 748671000627 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 748671000628 active site 748671000629 HIGH motif; other site 748671000630 KMSKS motif; other site 748671000631 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 748671000632 tRNA binding surface [nucleotide binding]; other site 748671000633 anticodon binding site; other site 748671000634 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 748671000635 dimer interface [polypeptide binding]; other site 748671000636 putative tRNA-binding site [nucleotide binding]; other site 748671000637 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 748671000638 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 748671000639 active site 748671000640 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 748671000641 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 748671000642 putative active site [active] 748671000643 putative metal binding site [ion binding]; other site 748671000644 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 748671000645 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 748671000646 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 748671000647 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 748671000648 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 748671000649 pur operon repressor; Provisional; Region: PRK09213 748671000650 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 748671000651 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748671000652 active site 748671000653 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 748671000654 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 748671000655 Substrate binding site; other site 748671000656 Mg++ binding site; other site 748671000657 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 748671000658 active site 748671000659 substrate binding site [chemical binding]; other site 748671000660 CoA binding site [chemical binding]; other site 748671000661 Bacterial surface layer protein; Region: SLAP; pfam03217 748671000662 Bacterial surface layer protein; Region: SLAP; pfam03217 748671000663 Bacterial surface layer protein; Region: SLAP; pfam03217 748671000664 Bacterial surface layer protein; Region: SLAP; pfam03217 748671000665 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 748671000666 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 748671000667 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748671000668 active site 748671000669 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 748671000670 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 748671000671 nucleotide binding site [chemical binding]; other site 748671000672 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 748671000673 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748671000674 Zn2+ binding site [ion binding]; other site 748671000675 Mg2+ binding site [ion binding]; other site 748671000676 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 748671000677 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 748671000678 CTP synthetase; Validated; Region: pyrG; PRK05380 748671000679 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 748671000680 Catalytic site [active] 748671000681 active site 748671000682 UTP binding site [chemical binding]; other site 748671000683 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 748671000684 active site 748671000685 putative oxyanion hole; other site 748671000686 catalytic triad [active] 748671000687 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 748671000688 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 748671000689 hinge; other site 748671000690 active site 748671000691 Peptidase family C69; Region: Peptidase_C69; pfam03577 748671000692 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 748671000693 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 748671000694 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 748671000695 xanthine permease; Region: pbuX; TIGR03173 748671000696 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748671000697 active site 748671000698 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748671000699 non-specific DNA binding site [nucleotide binding]; other site 748671000700 salt bridge; other site 748671000701 sequence-specific DNA binding site [nucleotide binding]; other site 748671000702 GMP synthase; Reviewed; Region: guaA; PRK00074 748671000703 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 748671000704 AMP/PPi binding site [chemical binding]; other site 748671000705 candidate oxyanion hole; other site 748671000706 catalytic triad [active] 748671000707 potential glutamine specificity residues [chemical binding]; other site 748671000708 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 748671000709 ATP Binding subdomain [chemical binding]; other site 748671000710 Ligand Binding sites [chemical binding]; other site 748671000711 Dimerization subdomain; other site 748671000712 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 748671000713 Integrase core domain; Region: rve; pfam00665 748671000714 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748671000715 sequence-specific DNA binding site [nucleotide binding]; other site 748671000716 salt bridge; other site 748671000717 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 748671000718 Predicted transcriptional regulators [Transcription]; Region: COG1733 748671000719 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 748671000720 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 748671000721 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 748671000722 putative NAD(P) binding site [chemical binding]; other site 748671000723 dimer interface [polypeptide binding]; other site 748671000724 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 748671000725 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 748671000726 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 748671000727 Probable transposase; Region: OrfB_IS605; pfam01385 748671000728 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 748671000729 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 748671000730 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 748671000731 Probable transposase; Region: OrfB_IS605; pfam01385 748671000732 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 748671000733 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 748671000734 DNA binding residues [nucleotide binding] 748671000735 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 748671000736 catalytic residues [active] 748671000737 catalytic nucleophile [active] 748671000738 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 748671000739 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 748671000740 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 748671000741 DNA binding site [nucleotide binding] 748671000742 active site 748671000743 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 748671000744 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 748671000745 catalytic residues [active] 748671000746 catalytic nucleophile [active] 748671000747 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 748671000748 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 748671000749 Probable transposase; Region: OrfB_IS605; pfam01385 748671000750 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 748671000751 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 748671000752 pore gating glutamate residue; other site 748671000753 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 748671000754 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 748671000755 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 748671000756 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 748671000757 active site 748671000758 FMN binding site [chemical binding]; other site 748671000759 substrate binding site [chemical binding]; other site 748671000760 putative catalytic residues [active] 748671000761 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 748671000762 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 748671000763 dimer interface [polypeptide binding]; other site 748671000764 active site 748671000765 glycine-pyridoxal phosphate binding site [chemical binding]; other site 748671000766 folate binding site [chemical binding]; other site 748671000767 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 748671000768 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 748671000769 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 748671000770 active site 748671000771 motif I; other site 748671000772 motif II; other site 748671000773 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 748671000774 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 748671000775 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 748671000776 Ca binding site [ion binding]; other site 748671000777 active site 748671000778 catalytic site [active] 748671000779 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 748671000780 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 748671000781 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 748671000782 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 748671000783 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 748671000784 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 748671000785 DEAD-like helicases superfamily; Region: DEXDc; smart00487 748671000786 ATP binding site [chemical binding]; other site 748671000787 Mg++ binding site [ion binding]; other site 748671000788 motif III; other site 748671000789 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748671000790 nucleotide binding region [chemical binding]; other site 748671000791 ATP-binding site [chemical binding]; other site 748671000792 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 748671000793 alanine racemase; Reviewed; Region: alr; PRK00053 748671000794 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 748671000795 active site 748671000796 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 748671000797 dimer interface [polypeptide binding]; other site 748671000798 substrate binding site [chemical binding]; other site 748671000799 catalytic residues [active] 748671000800 FOG: CBS domain [General function prediction only]; Region: COG0517 748671000801 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 748671000802 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 748671000803 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 748671000804 tetramer (dimer of dimers) interface [polypeptide binding]; other site 748671000805 NAD binding site [chemical binding]; other site 748671000806 dimer interface [polypeptide binding]; other site 748671000807 substrate binding site [chemical binding]; other site 748671000808 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 748671000809 putative active site [active] 748671000810 catalytic residue [active] 748671000811 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 748671000812 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 748671000813 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748671000814 ATP binding site [chemical binding]; other site 748671000815 putative Mg++ binding site [ion binding]; other site 748671000816 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748671000817 nucleotide binding region [chemical binding]; other site 748671000818 ATP-binding site [chemical binding]; other site 748671000819 TRCF domain; Region: TRCF; pfam03461 748671000820 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 748671000821 RNA binding surface [nucleotide binding]; other site 748671000822 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 748671000823 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 748671000824 Septum formation initiator; Region: DivIC; pfam04977 748671000825 S1 RNA binding domain; Region: S1; pfam00575 748671000826 RNA binding site [nucleotide binding]; other site 748671000827 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 748671000828 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 748671000829 Ligand Binding Site [chemical binding]; other site 748671000830 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 748671000831 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748671000832 Walker A motif; other site 748671000833 ATP binding site [chemical binding]; other site 748671000834 Walker B motif; other site 748671000835 arginine finger; other site 748671000836 Peptidase family M41; Region: Peptidase_M41; pfam01434 748671000837 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 748671000838 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 748671000839 dimerization interface [polypeptide binding]; other site 748671000840 domain crossover interface; other site 748671000841 redox-dependent activation switch; other site 748671000842 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 748671000843 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 748671000844 FMN binding site [chemical binding]; other site 748671000845 active site 748671000846 catalytic residues [active] 748671000847 substrate binding site [chemical binding]; other site 748671000848 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 748671000849 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 748671000850 dimer interface [polypeptide binding]; other site 748671000851 putative anticodon binding site; other site 748671000852 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 748671000853 motif 1; other site 748671000854 active site 748671000855 motif 2; other site 748671000856 motif 3; other site 748671000857 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 748671000858 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 748671000859 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 748671000860 putative active site [active] 748671000861 putative metal binding site [ion binding]; other site 748671000862 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 748671000863 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 748671000864 GAF domain; Region: GAF_2; pfam13185 748671000865 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 748671000866 Clp amino terminal domain; Region: Clp_N; pfam02861 748671000867 Clp amino terminal domain; Region: Clp_N; pfam02861 748671000868 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748671000869 Walker A motif; other site 748671000870 ATP binding site [chemical binding]; other site 748671000871 Walker B motif; other site 748671000872 arginine finger; other site 748671000873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748671000874 Walker A motif; other site 748671000875 ATP binding site [chemical binding]; other site 748671000876 Walker B motif; other site 748671000877 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 748671000878 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 748671000879 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 748671000880 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 748671000881 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 748671000882 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 748671000883 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 748671000884 RPB10 interaction site [polypeptide binding]; other site 748671000885 RPB1 interaction site [polypeptide binding]; other site 748671000886 RPB11 interaction site [polypeptide binding]; other site 748671000887 RPB3 interaction site [polypeptide binding]; other site 748671000888 RPB12 interaction site [polypeptide binding]; other site 748671000889 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 748671000890 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 748671000891 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 748671000892 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 748671000893 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 748671000894 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 748671000895 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 748671000896 G-loop; other site 748671000897 DNA binding site [nucleotide binding] 748671000898 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 748671000899 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 748671000900 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 748671000901 S17 interaction site [polypeptide binding]; other site 748671000902 S8 interaction site; other site 748671000903 16S rRNA interaction site [nucleotide binding]; other site 748671000904 streptomycin interaction site [chemical binding]; other site 748671000905 23S rRNA interaction site [nucleotide binding]; other site 748671000906 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 748671000907 30S ribosomal protein S7; Validated; Region: PRK05302 748671000908 elongation factor G; Reviewed; Region: PRK12739 748671000909 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 748671000910 G1 box; other site 748671000911 putative GEF interaction site [polypeptide binding]; other site 748671000912 GTP/Mg2+ binding site [chemical binding]; other site 748671000913 Switch I region; other site 748671000914 G2 box; other site 748671000915 G3 box; other site 748671000916 Switch II region; other site 748671000917 G4 box; other site 748671000918 G5 box; other site 748671000919 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 748671000920 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 748671000921 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 748671000922 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 748671000923 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 748671000924 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 748671000925 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 748671000926 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 748671000927 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 748671000928 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 748671000929 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 748671000930 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 748671000931 putative translocon binding site; other site 748671000932 protein-rRNA interface [nucleotide binding]; other site 748671000933 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 748671000934 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 748671000935 G-X-X-G motif; other site 748671000936 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 748671000937 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 748671000938 23S rRNA interface [nucleotide binding]; other site 748671000939 5S rRNA interface [nucleotide binding]; other site 748671000940 putative antibiotic binding site [chemical binding]; other site 748671000941 L25 interface [polypeptide binding]; other site 748671000942 L27 interface [polypeptide binding]; other site 748671000943 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 748671000944 23S rRNA interface [nucleotide binding]; other site 748671000945 putative translocon interaction site; other site 748671000946 signal recognition particle (SRP54) interaction site; other site 748671000947 L23 interface [polypeptide binding]; other site 748671000948 trigger factor interaction site; other site 748671000949 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 748671000950 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 748671000951 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 748671000952 RNA binding site [nucleotide binding]; other site 748671000953 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 748671000954 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 748671000955 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 748671000956 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 748671000957 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 748671000958 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 748671000959 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 748671000960 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 748671000961 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 748671000962 23S rRNA interface [nucleotide binding]; other site 748671000963 L21e interface [polypeptide binding]; other site 748671000964 5S rRNA interface [nucleotide binding]; other site 748671000965 L27 interface [polypeptide binding]; other site 748671000966 L5 interface [polypeptide binding]; other site 748671000967 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 748671000968 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 748671000969 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 748671000970 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 748671000971 23S rRNA binding site [nucleotide binding]; other site 748671000972 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 748671000973 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 748671000974 SecY translocase; Region: SecY; pfam00344 748671000975 adenylate kinase; Reviewed; Region: adk; PRK00279 748671000976 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 748671000977 AMP-binding site [chemical binding]; other site 748671000978 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 748671000979 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 748671000980 rRNA binding site [nucleotide binding]; other site 748671000981 predicted 30S ribosome binding site; other site 748671000982 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 748671000983 30S ribosomal protein S13; Region: bact_S13; TIGR03631 748671000984 30S ribosomal protein S11; Validated; Region: PRK05309 748671000985 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 748671000986 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 748671000987 alphaNTD homodimer interface [polypeptide binding]; other site 748671000988 alphaNTD - beta interaction site [polypeptide binding]; other site 748671000989 alphaNTD - beta' interaction site [polypeptide binding]; other site 748671000990 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 748671000991 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 748671000992 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13640 748671000993 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 748671000994 Walker A/P-loop; other site 748671000995 ATP binding site [chemical binding]; other site 748671000996 Q-loop/lid; other site 748671000997 ABC transporter signature motif; other site 748671000998 Walker B; other site 748671000999 D-loop; other site 748671001000 H-loop/switch region; other site 748671001001 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13641 748671001002 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 748671001003 Walker A/P-loop; other site 748671001004 ATP binding site [chemical binding]; other site 748671001005 Q-loop/lid; other site 748671001006 ABC transporter signature motif; other site 748671001007 Walker B; other site 748671001008 D-loop; other site 748671001009 H-loop/switch region; other site 748671001010 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 748671001011 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 748671001012 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 748671001013 dimerization interface 3.5A [polypeptide binding]; other site 748671001014 active site 748671001015 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 748671001016 23S rRNA interface [nucleotide binding]; other site 748671001017 L3 interface [polypeptide binding]; other site 748671001018 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 748671001019 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 748671001020 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748671001021 Coenzyme A binding pocket [chemical binding]; other site 748671001022 DJ-1 family protein; Region: not_thiJ; TIGR01383 748671001023 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 748671001024 conserved cys residue [active] 748671001025 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 748671001026 hypothetical protein; Provisional; Region: PRK10621 748671001027 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 748671001028 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 748671001029 catalytic core [active] 748671001030 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 748671001031 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 748671001032 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 748671001033 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 748671001034 catalytic core [active] 748671001035 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 748671001036 AAA domain; Region: AAA_33; pfam13671 748671001037 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 748671001038 trimer interface [polypeptide binding]; other site 748671001039 active site 748671001040 G bulge; other site 748671001041 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 748671001042 trimer interface [polypeptide binding]; other site 748671001043 active site 748671001044 DNA repair protein RadA; Provisional; Region: PRK11823 748671001045 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 748671001046 Walker A motif/ATP binding site; other site 748671001047 ATP binding site [chemical binding]; other site 748671001048 Walker B motif; other site 748671001049 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 748671001050 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 748671001051 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 748671001052 active site 748671001053 HIGH motif; other site 748671001054 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 748671001055 active site 748671001056 KMSKS motif; other site 748671001057 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 748671001058 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 748671001059 active site 748671001060 HIGH motif; other site 748671001061 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 748671001062 KMSKS motif; other site 748671001063 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 748671001064 tRNA binding surface [nucleotide binding]; other site 748671001065 anticodon binding site; other site 748671001066 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 748671001067 active site 748671001068 metal binding site [ion binding]; metal-binding site 748671001069 dimerization interface [polypeptide binding]; other site 748671001070 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 748671001071 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 748671001072 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 748671001073 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 748671001074 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 748671001075 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 748671001076 N- and C-terminal domain interface [polypeptide binding]; other site 748671001077 active site 748671001078 catalytic site [active] 748671001079 metal binding site [ion binding]; metal-binding site 748671001080 carbohydrate binding site [chemical binding]; other site 748671001081 ATP binding site [chemical binding]; other site 748671001082 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 748671001083 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 748671001084 TPP-binding site; other site 748671001085 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 748671001086 PYR/PP interface [polypeptide binding]; other site 748671001087 dimer interface [polypeptide binding]; other site 748671001088 TPP binding site [chemical binding]; other site 748671001089 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 748671001090 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 748671001091 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 748671001092 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 748671001093 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 748671001094 putative homodimer interface [polypeptide binding]; other site 748671001095 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 748671001096 heterodimer interface [polypeptide binding]; other site 748671001097 homodimer interface [polypeptide binding]; other site 748671001098 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 748671001099 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 748671001100 23S rRNA interface [nucleotide binding]; other site 748671001101 L7/L12 interface [polypeptide binding]; other site 748671001102 putative thiostrepton binding site; other site 748671001103 L25 interface [polypeptide binding]; other site 748671001104 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 748671001105 mRNA/rRNA interface [nucleotide binding]; other site 748671001106 PBP superfamily domain; Region: PBP_like_2; cl17296 748671001107 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 748671001108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748671001109 dimer interface [polypeptide binding]; other site 748671001110 conserved gate region; other site 748671001111 putative PBP binding loops; other site 748671001112 ABC-ATPase subunit interface; other site 748671001113 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 748671001114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748671001115 dimer interface [polypeptide binding]; other site 748671001116 conserved gate region; other site 748671001117 putative PBP binding loops; other site 748671001118 ABC-ATPase subunit interface; other site 748671001119 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 748671001120 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 748671001121 Walker A/P-loop; other site 748671001122 ATP binding site [chemical binding]; other site 748671001123 Q-loop/lid; other site 748671001124 ABC transporter signature motif; other site 748671001125 Walker B; other site 748671001126 D-loop; other site 748671001127 H-loop/switch region; other site 748671001128 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14251 748671001129 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 748671001130 Walker A/P-loop; other site 748671001131 ATP binding site [chemical binding]; other site 748671001132 Q-loop/lid; other site 748671001133 ABC transporter signature motif; other site 748671001134 Walker B; other site 748671001135 D-loop; other site 748671001136 H-loop/switch region; other site 748671001137 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 748671001138 PhoU domain; Region: PhoU; pfam01895 748671001139 PhoU domain; Region: PhoU; pfam01895 748671001140 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 748671001141 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 748671001142 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 748671001143 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 748671001144 23S rRNA interface [nucleotide binding]; other site 748671001145 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 748671001146 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 748671001147 core dimer interface [polypeptide binding]; other site 748671001148 peripheral dimer interface [polypeptide binding]; other site 748671001149 L10 interface [polypeptide binding]; other site 748671001150 L11 interface [polypeptide binding]; other site 748671001151 putative EF-Tu interaction site [polypeptide binding]; other site 748671001152 putative EF-G interaction site [polypeptide binding]; other site 748671001153 Ion transport protein; Region: Ion_trans; pfam00520 748671001154 Ion channel; Region: Ion_trans_2; pfam07885 748671001155 Methyltransferase domain; Region: Methyltransf_31; pfam13847 748671001156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748671001157 S-adenosylmethionine binding site [chemical binding]; other site 748671001158 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 748671001159 nucleoside/Zn binding site; other site 748671001160 dimer interface [polypeptide binding]; other site 748671001161 catalytic motif [active] 748671001162 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 748671001163 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748671001164 Walker A motif; other site 748671001165 ATP binding site [chemical binding]; other site 748671001166 Walker B motif; other site 748671001167 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 748671001168 Domain of unknown function (DUF1792); Region: DUF1792; cl07392 748671001169 Domain of unknown function (DUF1792); Region: DUF1792; cl07392 748671001170 hypothetical protein; Validated; Region: PRK00153 748671001171 recombination protein RecR; Reviewed; Region: recR; PRK00076 748671001172 RecR protein; Region: RecR; pfam02132 748671001173 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 748671001174 putative active site [active] 748671001175 putative metal-binding site [ion binding]; other site 748671001176 tetramer interface [polypeptide binding]; other site 748671001177 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 748671001178 thymidylate kinase; Validated; Region: tmk; PRK00698 748671001179 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 748671001180 TMP-binding site; other site 748671001181 ATP-binding site [chemical binding]; other site 748671001182 Protein of unknown function (DUF970); Region: DUF970; cl17525 748671001183 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 748671001184 DNA polymerase III subunit delta'; Validated; Region: PRK08485 748671001185 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 748671001186 Predicted methyltransferases [General function prediction only]; Region: COG0313 748671001187 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 748671001188 putative SAM binding site [chemical binding]; other site 748671001189 putative homodimer interface [polypeptide binding]; other site 748671001190 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 748671001191 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 748671001192 active site 748671001193 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 748671001194 active site 748671001195 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 748671001196 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 748671001197 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 748671001198 Glycoprotease family; Region: Peptidase_M22; pfam00814 748671001199 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 748671001200 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748671001201 Coenzyme A binding pocket [chemical binding]; other site 748671001202 UGMP family protein; Validated; Region: PRK09604 748671001203 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 748671001204 Transposase; Region: DEDD_Tnp_IS110; pfam01548 748671001205 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 748671001206 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 748671001207 Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884 748671001208 HTH-like domain; Region: HTH_21; pfam13276 748671001209 Integrase core domain; Region: rve; pfam00665 748671001210 Integrase core domain; Region: rve_2; pfam13333 748671001211 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 748671001212 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 748671001213 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 748671001214 ABC transporter; Region: ABC_tran_2; pfam12848 748671001215 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 748671001216 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 748671001217 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 748671001218 CoA binding domain; Region: CoA_binding; pfam02629 748671001219 Transcriptional regulators [Transcription]; Region: PurR; COG1609 748671001220 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 748671001221 DNA binding site [nucleotide binding] 748671001222 domain linker motif; other site 748671001223 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 748671001224 dimerization interface [polypeptide binding]; other site 748671001225 ligand binding site [chemical binding]; other site 748671001226 sodium binding site [ion binding]; other site 748671001227 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 748671001228 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 748671001229 substrate binding [chemical binding]; other site 748671001230 active site 748671001231 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 748671001232 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 748671001233 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 748671001234 active site turn [active] 748671001235 phosphorylation site [posttranslational modification] 748671001236 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 748671001237 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 748671001238 HPr interaction site; other site 748671001239 glycerol kinase (GK) interaction site [polypeptide binding]; other site 748671001240 active site 748671001241 phosphorylation site [posttranslational modification] 748671001242 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 748671001243 NlpC/P60 family; Region: NLPC_P60; cl17555 748671001244 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 748671001245 oligomerisation interface [polypeptide binding]; other site 748671001246 mobile loop; other site 748671001247 roof hairpin; other site 748671001248 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 748671001249 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 748671001250 ring oligomerisation interface [polypeptide binding]; other site 748671001251 ATP/Mg binding site [chemical binding]; other site 748671001252 stacking interactions; other site 748671001253 hinge regions; other site 748671001254 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 748671001255 MutS domain I; Region: MutS_I; pfam01624 748671001256 MutS domain II; Region: MutS_II; pfam05188 748671001257 MutS domain III; Region: MutS_III; pfam05192 748671001258 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 748671001259 Walker A/P-loop; other site 748671001260 ATP binding site [chemical binding]; other site 748671001261 Q-loop/lid; other site 748671001262 ABC transporter signature motif; other site 748671001263 Walker B; other site 748671001264 D-loop; other site 748671001265 H-loop/switch region; other site 748671001266 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 748671001267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748671001268 ATP binding site [chemical binding]; other site 748671001269 Mg2+ binding site [ion binding]; other site 748671001270 G-X-G motif; other site 748671001271 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 748671001272 ATP binding site [chemical binding]; other site 748671001273 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 748671001274 RuvA N terminal domain; Region: RuvA_N; pfam01330 748671001275 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 748671001276 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 748671001277 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748671001278 Walker A motif; other site 748671001279 ATP binding site [chemical binding]; other site 748671001280 Walker B motif; other site 748671001281 arginine finger; other site 748671001282 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 748671001283 Preprotein translocase subunit; Region: YajC; pfam02699 748671001284 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 748671001285 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 748671001286 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 748671001287 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 748671001288 active site 748671001289 DNA polymerase IV; Validated; Region: PRK02406 748671001290 DNA binding site [nucleotide binding] 748671001291 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 748671001292 DHH family; Region: DHH; pfam01368 748671001293 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 748671001294 DEAD-like helicases superfamily; Region: DEXDc; smart00487 748671001295 ATP binding site [chemical binding]; other site 748671001296 putative Mg++ binding site [ion binding]; other site 748671001297 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748671001298 nucleotide binding region [chemical binding]; other site 748671001299 ATP-binding site [chemical binding]; other site 748671001300 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 748671001301 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 748671001302 motif 1; other site 748671001303 active site 748671001304 motif 2; other site 748671001305 motif 3; other site 748671001306 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 748671001307 DHHA1 domain; Region: DHHA1; pfam02272 748671001308 hypothetical protein; Provisional; Region: PRK05473 748671001309 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 748671001310 hypothetical protein; Provisional; Region: PRK13678 748671001311 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 748671001312 MutS domain III; Region: MutS_III; pfam05192 748671001313 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 748671001314 Walker A/P-loop; other site 748671001315 ATP binding site [chemical binding]; other site 748671001316 Q-loop/lid; other site 748671001317 ABC transporter signature motif; other site 748671001318 Walker B; other site 748671001319 D-loop; other site 748671001320 H-loop/switch region; other site 748671001321 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 748671001322 Smr domain; Region: Smr; pfam01713 748671001323 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 748671001324 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 748671001325 catalytic residues [active] 748671001326 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 748671001327 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 748671001328 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 748671001329 glutamate racemase; Provisional; Region: PRK00865 748671001330 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 748671001331 active site 748671001332 dimerization interface [polypeptide binding]; other site 748671001333 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 748671001334 Mechanosensitive ion channel; Region: MS_channel; pfam00924 748671001335 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 748671001336 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 748671001337 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 748671001338 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 748671001339 active site 748671001340 catabolite control protein A; Region: ccpA; TIGR01481 748671001341 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 748671001342 DNA binding site [nucleotide binding] 748671001343 domain linker motif; other site 748671001344 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 748671001345 dimerization interface [polypeptide binding]; other site 748671001346 effector binding site; other site 748671001347 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 748671001348 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 748671001349 active site 748671001350 catalytic site [active] 748671001351 metal binding site [ion binding]; metal-binding site 748671001352 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 748671001353 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 748671001354 active site 748671001355 metal binding site [ion binding]; metal-binding site 748671001356 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 748671001357 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 748671001358 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 748671001359 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748671001360 active site 748671001361 motif I; other site 748671001362 motif II; other site 748671001363 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748671001364 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 748671001365 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 748671001366 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 748671001367 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 748671001368 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748671001369 Domain of unknown function (DUF4323); Region: DUF4323; pfam14211 748671001370 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 748671001371 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 748671001372 putative ADP-binding pocket [chemical binding]; other site 748671001373 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 748671001374 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; pfam13579 748671001375 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 748671001376 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 748671001377 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 748671001378 Sulfatase; Region: Sulfatase; pfam00884 748671001379 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 748671001380 ribonuclease R; Region: RNase_R; TIGR02063 748671001381 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 748671001382 RNB domain; Region: RNB; pfam00773 748671001383 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 748671001384 RNA binding site [nucleotide binding]; other site 748671001385 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 748671001386 SmpB-tmRNA interface; other site 748671001387 Domain of unknown function (DUF4323); Region: DUF4323; pfam14211 748671001388 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 748671001389 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 748671001390 active pocket/dimerization site; other site 748671001391 active site 748671001392 phosphorylation site [posttranslational modification] 748671001393 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 748671001394 active site 748671001395 phosphorylation site [posttranslational modification] 748671001396 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 748671001397 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 748671001398 Domain of unknown function (DUF956); Region: DUF956; pfam06115 748671001399 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748671001400 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748671001401 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 748671001402 dimerization interface [polypeptide binding]; other site 748671001403 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 748671001404 putative trimer interface [polypeptide binding]; other site 748671001405 putative CoA binding site [chemical binding]; other site 748671001406 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 748671001407 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 748671001408 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 748671001409 putative catalytic cysteine [active] 748671001410 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 748671001411 putative active site [active] 748671001412 metal binding site [ion binding]; metal-binding site 748671001413 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 748671001414 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 748671001415 glutaminase active site [active] 748671001416 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 748671001417 dimer interface [polypeptide binding]; other site 748671001418 active site 748671001419 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 748671001420 dimer interface [polypeptide binding]; other site 748671001421 active site 748671001422 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 748671001423 HTH domain; Region: HTH_11; pfam08279 748671001424 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 748671001425 active site 748671001426 P-loop; other site 748671001427 phosphorylation site [posttranslational modification] 748671001428 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 748671001429 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 748671001430 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 748671001431 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 748671001432 active site 748671001433 P-loop; other site 748671001434 phosphorylation site [posttranslational modification] 748671001435 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 748671001436 active site 748671001437 P-loop; other site 748671001438 phosphorylation site [posttranslational modification] 748671001439 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 748671001440 active site 748671001441 phosphorylation site [posttranslational modification] 748671001442 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 748671001443 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 748671001444 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 748671001445 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 748671001446 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 748671001447 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 748671001448 nudix motif; other site 748671001449 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748671001450 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748671001451 non-specific DNA binding site [nucleotide binding]; other site 748671001452 salt bridge; other site 748671001453 sequence-specific DNA binding site [nucleotide binding]; other site 748671001454 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 748671001455 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 748671001456 active site 748671001457 ATP binding site [chemical binding]; other site 748671001458 substrate binding site [chemical binding]; other site 748671001459 activation loop (A-loop); other site 748671001460 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748671001461 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748671001462 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 748671001463 Walker A/P-loop; other site 748671001464 ATP binding site [chemical binding]; other site 748671001465 Q-loop/lid; other site 748671001466 ABC transporter signature motif; other site 748671001467 Walker B; other site 748671001468 D-loop; other site 748671001469 H-loop/switch region; other site 748671001470 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 748671001471 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 748671001472 active site 748671001473 metal-binding site [ion binding] 748671001474 nucleotide-binding site [chemical binding]; other site 748671001475 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 748671001476 AAA ATPase domain; Region: AAA_16; pfam13191 748671001477 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 748671001478 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748671001479 ATP binding site [chemical binding]; other site 748671001480 putative Mg++ binding site [ion binding]; other site 748671001481 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748671001482 nucleotide binding region [chemical binding]; other site 748671001483 ATP-binding site [chemical binding]; other site 748671001484 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 748671001485 dimer interface [polypeptide binding]; other site 748671001486 FMN binding site [chemical binding]; other site 748671001487 NADPH bind site [chemical binding]; other site 748671001488 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 748671001489 maltose O-acetyltransferase; Provisional; Region: PRK10092 748671001490 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 748671001491 active site 748671001492 substrate binding site [chemical binding]; other site 748671001493 trimer interface [polypeptide binding]; other site 748671001494 CoA binding site [chemical binding]; other site 748671001495 4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194 748671001496 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 748671001497 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 748671001498 active site 748671001499 metal binding site [ion binding]; metal-binding site 748671001500 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 748671001501 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 748671001502 DNA binding residues [nucleotide binding] 748671001503 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 748671001504 catalytic residues [active] 748671001505 catalytic nucleophile [active] 748671001506 Probable transposase; Region: OrfB_IS605; pfam01385 748671001507 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 748671001508 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 748671001509 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 748671001510 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 748671001511 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 748671001512 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 748671001513 catalytic core [active] 748671001514 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 748671001515 catalytic core [active] 748671001516 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 748671001517 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 748671001518 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 748671001519 active site 748671001520 catalytic site [active] 748671001521 Transcriptional regulators [Transcription]; Region: PurR; COG1609 748671001522 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 748671001523 DNA binding site [nucleotide binding] 748671001524 domain linker motif; other site 748671001525 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 748671001526 dimerization interface [polypeptide binding]; other site 748671001527 ligand binding site [chemical binding]; other site 748671001528 sodium binding site [ion binding]; other site 748671001529 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 748671001530 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 748671001531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748671001532 dimer interface [polypeptide binding]; other site 748671001533 conserved gate region; other site 748671001534 putative PBP binding loops; other site 748671001535 ABC-ATPase subunit interface; other site 748671001536 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 748671001537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748671001538 dimer interface [polypeptide binding]; other site 748671001539 conserved gate region; other site 748671001540 putative PBP binding loops; other site 748671001541 ABC-ATPase subunit interface; other site 748671001542 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 748671001543 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 748671001544 substrate binding [chemical binding]; other site 748671001545 active site 748671001546 Src homology 2 (SH2) domain; Region: SH2; cl15255 748671001547 phosphotyrosine binding pocket [polypeptide binding]; other site 748671001548 hydrophobic binding pocket [polypeptide binding]; other site 748671001549 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 748671001550 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 748671001551 Walker A/P-loop; other site 748671001552 ATP binding site [chemical binding]; other site 748671001553 Q-loop/lid; other site 748671001554 ABC transporter signature motif; other site 748671001555 Walker B; other site 748671001556 D-loop; other site 748671001557 H-loop/switch region; other site 748671001558 TOBE domain; Region: TOBE_2; pfam08402 748671001559 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 748671001560 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 748671001561 active site 748671001562 homodimer interface [polypeptide binding]; other site 748671001563 catalytic site [active] 748671001564 aromatic amino acid aminotransferase; Validated; Region: PRK07309 748671001565 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748671001566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748671001567 homodimer interface [polypeptide binding]; other site 748671001568 catalytic residue [active] 748671001569 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 748671001570 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 748671001571 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 748671001572 tetramer (dimer of dimers) interface [polypeptide binding]; other site 748671001573 active site 748671001574 dimer interface [polypeptide binding]; other site 748671001575 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 748671001576 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 748671001577 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 748671001578 putative active site [active] 748671001579 Bacterial surface layer protein; Region: SLAP; pfam03217 748671001580 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 748671001581 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 748671001582 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748671001583 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 748671001584 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 748671001585 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 748671001586 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 748671001587 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 748671001588 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 748671001589 peptide binding site [polypeptide binding]; other site 748671001590 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 748671001591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748671001592 DNA-binding site [nucleotide binding]; DNA binding site 748671001593 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 748671001594 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 748671001595 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 748671001596 active site 748671001597 nucleotide binding site [chemical binding]; other site 748671001598 HIGH motif; other site 748671001599 KMSKS motif; other site 748671001600 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 748671001601 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 748671001602 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 748671001603 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 748671001604 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 748671001605 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 748671001606 active site 748671001607 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 748671001608 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 748671001609 homodimer interface [polypeptide binding]; other site 748671001610 NAD binding pocket [chemical binding]; other site 748671001611 ATP binding pocket [chemical binding]; other site 748671001612 Mg binding site [ion binding]; other site 748671001613 active-site loop [active] 748671001614 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 748671001615 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 748671001616 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 748671001617 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 748671001618 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 748671001619 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 748671001620 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 748671001621 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 748671001622 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 748671001623 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 748671001624 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 748671001625 hypothetical protein; Provisional; Region: PRK04351 748671001626 SprT homologues; Region: SprT; cl01182 748671001627 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 748671001628 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 748671001629 Part of AAA domain; Region: AAA_19; pfam13245 748671001630 Family description; Region: UvrD_C_2; pfam13538 748671001631 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 748671001632 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 748671001633 nucleotide binding pocket [chemical binding]; other site 748671001634 K-X-D-G motif; other site 748671001635 catalytic site [active] 748671001636 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 748671001637 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 748671001638 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 748671001639 Dimer interface [polypeptide binding]; other site 748671001640 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 748671001641 putative dimer interface [polypeptide binding]; other site 748671001642 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 748671001643 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 748671001644 putative dimer interface [polypeptide binding]; other site 748671001645 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 748671001646 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 748671001647 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 748671001648 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 748671001649 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 748671001650 GatB domain; Region: GatB_Yqey; smart00845 748671001651 putative lipid kinase; Reviewed; Region: PRK13337 748671001652 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 748671001653 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 748671001654 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 748671001655 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 748671001656 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 748671001657 Walker A/P-loop; other site 748671001658 ATP binding site [chemical binding]; other site 748671001659 Q-loop/lid; other site 748671001660 ABC transporter signature motif; other site 748671001661 Walker B; other site 748671001662 D-loop; other site 748671001663 H-loop/switch region; other site 748671001664 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 748671001665 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748671001666 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 748671001667 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 748671001668 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 748671001669 catalytic residues [active] 748671001670 catalytic nucleophile [active] 748671001671 Presynaptic Site I dimer interface [polypeptide binding]; other site 748671001672 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 748671001673 Synaptic Flat tetramer interface [polypeptide binding]; other site 748671001674 Synaptic Site I dimer interface [polypeptide binding]; other site 748671001675 DNA binding site [nucleotide binding] 748671001676 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 748671001677 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 748671001678 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 748671001679 Helix-turn-helix domain; Region: HTH_38; pfam13936 748671001680 Integrase core domain; Region: rve; pfam00665 748671001681 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 748671001682 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 748671001683 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 748671001684 DNA binding residues [nucleotide binding] 748671001685 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 748671001686 catalytic residues [active] 748671001687 catalytic nucleophile [active] 748671001688 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 748671001689 Probable transposase; Region: OrfB_IS605; pfam01385 748671001690 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 748671001691 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 748671001692 Beta-lactamase; Region: Beta-lactamase; pfam00144 748671001693 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 748671001694 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 748671001695 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 748671001696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748671001697 S-adenosylmethionine binding site [chemical binding]; other site 748671001698 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 748671001699 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748671001700 Coenzyme A binding pocket [chemical binding]; other site 748671001701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748671001702 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748671001703 putative substrate translocation pore; other site 748671001704 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748671001705 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748671001706 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 748671001707 myosin-cross-reactive antigen; Provisional; Region: PRK13977 748671001708 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748671001709 Coenzyme A binding pocket [chemical binding]; other site 748671001710 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 748671001711 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 748671001712 active site 748671001713 catalytic tetrad [active] 748671001714 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 748671001715 Divergent AAA domain; Region: AAA_4; pfam04326 748671001716 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 748671001717 Penicillinase repressor; Region: Pencillinase_R; cl17580 748671001718 uracil transporter; Provisional; Region: PRK10720 748671001719 Sulfate transporter family; Region: Sulfate_transp; pfam00916 748671001720 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 748671001721 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748671001722 active site 748671001723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748671001724 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748671001725 putative substrate translocation pore; other site 748671001726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748671001727 drug efflux system protein MdtG; Provisional; Region: PRK09874 748671001728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748671001729 putative substrate translocation pore; other site 748671001730 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 748671001731 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 748671001732 oligomer interface [polypeptide binding]; other site 748671001733 active site 748671001734 metal binding site [ion binding]; metal-binding site 748671001735 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 748671001736 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 748671001737 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 748671001738 ABC transporter; Region: ABC_tran_2; pfam12848 748671001739 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 748671001740 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 748671001741 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 748671001742 active site 748671001743 catalytic tetrad [active] 748671001744 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 748671001745 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 748671001746 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 748671001747 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 748671001748 catalytic triad [active] 748671001749 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 748671001750 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 748671001751 substrate binding pocket [chemical binding]; other site 748671001752 membrane-bound complex binding site; other site 748671001753 hinge residues; other site 748671001754 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 748671001755 Transcriptional regulators [Transcription]; Region: MarR; COG1846 748671001756 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748671001757 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748671001758 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748671001759 Walker A/P-loop; other site 748671001760 ATP binding site [chemical binding]; other site 748671001761 Q-loop/lid; other site 748671001762 ABC transporter signature motif; other site 748671001763 Walker B; other site 748671001764 D-loop; other site 748671001765 H-loop/switch region; other site 748671001766 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748671001767 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748671001768 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 748671001769 Walker A/P-loop; other site 748671001770 ATP binding site [chemical binding]; other site 748671001771 Q-loop/lid; other site 748671001772 ABC transporter signature motif; other site 748671001773 Walker B; other site 748671001774 D-loop; other site 748671001775 H-loop/switch region; other site 748671001776 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 748671001777 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748671001778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748671001779 putative substrate translocation pore; other site 748671001780 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 748671001781 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 748671001782 Sugar specificity; other site 748671001783 Pyrimidine base specificity; other site 748671001784 ATP-binding site [chemical binding]; other site 748671001785 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 748671001786 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 748671001787 Walker A/P-loop; other site 748671001788 ATP binding site [chemical binding]; other site 748671001789 Q-loop/lid; other site 748671001790 ABC transporter signature motif; other site 748671001791 Walker B; other site 748671001792 D-loop; other site 748671001793 H-loop/switch region; other site 748671001794 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 748671001795 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 748671001796 substrate binding pocket [chemical binding]; other site 748671001797 membrane-bound complex binding site; other site 748671001798 hinge residues; other site 748671001799 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 748671001800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748671001801 dimer interface [polypeptide binding]; other site 748671001802 conserved gate region; other site 748671001803 putative PBP binding loops; other site 748671001804 ABC-ATPase subunit interface; other site 748671001805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748671001806 dimer interface [polypeptide binding]; other site 748671001807 conserved gate region; other site 748671001808 putative PBP binding loops; other site 748671001809 ABC-ATPase subunit interface; other site 748671001810 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 748671001811 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 748671001812 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 748671001813 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 748671001814 DNA binding residues [nucleotide binding] 748671001815 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 748671001816 catalytic residues [active] 748671001817 catalytic nucleophile [active] 748671001818 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 748671001819 Probable transposase; Region: OrfB_IS605; pfam01385 748671001820 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 748671001821 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 748671001822 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 748671001823 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 748671001824 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 748671001825 nucleotide binding site/active site [active] 748671001826 HIT family signature motif; other site 748671001827 catalytic residue [active] 748671001828 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 748671001829 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 748671001830 substrate binding site [chemical binding]; other site 748671001831 dimer interface [polypeptide binding]; other site 748671001832 ATP binding site [chemical binding]; other site 748671001833 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 748671001834 tetramer (dimer of dimers) interface [polypeptide binding]; other site 748671001835 active site 748671001836 dimer interface [polypeptide binding]; other site 748671001837 K+ potassium transporter; Region: K_trans; pfam02705 748671001838 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 748671001839 active site 748671001840 tetramer interface [polypeptide binding]; other site 748671001841 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748671001842 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 748671001843 DNA-binding site [nucleotide binding]; DNA binding site 748671001844 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 748671001845 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 748671001846 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 748671001847 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748671001848 Enterocin A Immunity; Region: EntA_Immun; pfam08951 748671001849 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 748671001850 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 748671001851 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 748671001852 putative phosphoketolase; Provisional; Region: PRK05261 748671001853 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 748671001854 TPP-binding site; other site 748671001855 XFP C-terminal domain; Region: XFP_C; pfam09363 748671001856 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 748671001857 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 748671001858 active site 748671001859 nucleophile elbow; other site 748671001860 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 748671001861 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748671001862 active site 748671001863 motif I; other site 748671001864 motif II; other site 748671001865 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748671001866 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 748671001867 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 748671001868 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 748671001869 active site turn [active] 748671001870 phosphorylation site [posttranslational modification] 748671001871 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 748671001872 active site turn [active] 748671001873 phosphorylation site [posttranslational modification] 748671001874 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 748671001875 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 748671001876 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 748671001877 putative active site [active] 748671001878 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 748671001879 HPr interaction site; other site 748671001880 glycerol kinase (GK) interaction site [polypeptide binding]; other site 748671001881 active site 748671001882 phosphorylation site [posttranslational modification] 748671001883 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 748671001884 putative FMN binding site [chemical binding]; other site 748671001885 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 748671001886 Domain of unknown function DUF21; Region: DUF21; pfam01595 748671001887 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 748671001888 Transporter associated domain; Region: CorC_HlyC; smart01091 748671001889 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748671001890 active site 748671001891 FMN-binding domain; Region: FMN_bind; cl01081 748671001892 L-aspartate oxidase; Provisional; Region: PRK06175 748671001893 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 748671001894 Predicted oxidoreductase [General function prediction only]; Region: COG3573 748671001895 FMN-binding domain; Region: FMN_bind; pfam04205 748671001896 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 748671001897 L-aspartate oxidase; Provisional; Region: PRK06175 748671001898 Amino acid permease; Region: AA_permease_2; pfam13520 748671001899 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 748671001900 active site 748671001901 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 748671001902 DEAD-like helicases superfamily; Region: DEXDc; smart00487 748671001903 DEAD/DEAH box helicase; Region: DEAD; pfam00270 748671001904 ATP binding site [chemical binding]; other site 748671001905 putative Mg++ binding site [ion binding]; other site 748671001906 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748671001907 nucleotide binding region [chemical binding]; other site 748671001908 ATP-binding site [chemical binding]; other site 748671001909 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 748671001910 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 748671001911 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 748671001912 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 748671001913 active site 748671001914 homodimer interface [polypeptide binding]; other site 748671001915 Predicted membrane protein [Function unknown]; Region: COG2246 748671001916 GtrA-like protein; Region: GtrA; pfam04138 748671001917 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 748671001918 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 748671001919 methionine aminopeptidase; Provisional; Region: PRK08671 748671001920 active site 748671001921 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 748671001922 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 748671001923 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 748671001924 active site 748671001925 tetramer interface; other site 748671001926 putative acyltransferase; Provisional; Region: PRK05790 748671001927 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 748671001928 dimer interface [polypeptide binding]; other site 748671001929 active site 748671001930 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 748671001931 homodimer interface [polypeptide binding]; other site 748671001932 catalytic residues [active] 748671001933 NAD binding site [chemical binding]; other site 748671001934 substrate binding pocket [chemical binding]; other site 748671001935 flexible flap; other site 748671001936 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 748671001937 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 748671001938 dimer interface [polypeptide binding]; other site 748671001939 active site 748671001940 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 748671001941 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 748671001942 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 748671001943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748671001944 S-adenosylmethionine binding site [chemical binding]; other site 748671001945 recombination regulator RecX; Provisional; Region: recX; PRK14135 748671001946 FOG: CBS domain [General function prediction only]; Region: COG0517 748671001947 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 748671001948 Transporter associated domain; Region: CorC_HlyC; pfam03471 748671001949 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 748671001950 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 748671001951 G1 box; other site 748671001952 putative GEF interaction site [polypeptide binding]; other site 748671001953 GTP/Mg2+ binding site [chemical binding]; other site 748671001954 Switch I region; other site 748671001955 G2 box; other site 748671001956 G3 box; other site 748671001957 Switch II region; other site 748671001958 G4 box; other site 748671001959 G5 box; other site 748671001960 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 748671001961 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748671001962 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748671001963 non-specific DNA binding site [nucleotide binding]; other site 748671001964 salt bridge; other site 748671001965 sequence-specific DNA binding site [nucleotide binding]; other site 748671001966 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748671001967 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 748671001968 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 748671001969 Walker A/P-loop; other site 748671001970 ATP binding site [chemical binding]; other site 748671001971 Q-loop/lid; other site 748671001972 ABC transporter signature motif; other site 748671001973 Walker B; other site 748671001974 D-loop; other site 748671001975 H-loop/switch region; other site 748671001976 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 748671001977 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 748671001978 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 748671001979 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 748671001980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748671001981 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 748671001982 Walker A motif; other site 748671001983 ATP binding site [chemical binding]; other site 748671001984 Walker B motif; other site 748671001985 arginine finger; other site 748671001986 UvrB/uvrC motif; Region: UVR; pfam02151 748671001987 endopeptidase Clp ATP-binding regulatory subunit (clpX); Region: clpX; TIGR00382 748671001988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748671001989 Walker A motif; other site 748671001990 ATP binding site [chemical binding]; other site 748671001991 Walker B motif; other site 748671001992 arginine finger; other site 748671001993 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 748671001994 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 748671001995 dimerization domain swap beta strand [polypeptide binding]; other site 748671001996 regulatory protein interface [polypeptide binding]; other site 748671001997 active site 748671001998 regulatory phosphorylation site [posttranslational modification]; other site 748671001999 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 748671002000 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 748671002001 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 748671002002 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 748671002003 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 748671002004 ArsC family; Region: ArsC; pfam03960 748671002005 putative catalytic residues [active] 748671002006 thiol/disulfide switch; other site 748671002007 adaptor protein; Provisional; Region: PRK02315 748671002008 Competence protein CoiA-like family; Region: CoiA; cl11541 748671002009 Thioredoxin; Region: Thioredoxin_5; pfam13743 748671002010 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 748671002011 putative active site [active] 748671002012 putative metal binding residues [ion binding]; other site 748671002013 signature motif; other site 748671002014 putative triphosphate binding site [ion binding]; other site 748671002015 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 748671002016 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 748671002017 synthetase active site [active] 748671002018 NTP binding site [chemical binding]; other site 748671002019 metal binding site [ion binding]; metal-binding site 748671002020 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 748671002021 ATP-NAD kinase; Region: NAD_kinase; pfam01513 748671002022 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 748671002023 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 748671002024 active site 748671002025 myosin-cross-reactive antigen; Provisional; Region: PRK13977 748671002026 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 748671002027 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 748671002028 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 748671002029 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 748671002030 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 748671002031 Domain of unknown function DUF20; Region: UPF0118; pfam01594 748671002032 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 748671002033 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 748671002034 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 748671002035 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 748671002036 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 748671002037 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 748671002038 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 748671002039 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 748671002040 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 748671002041 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 748671002042 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 748671002043 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 748671002044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 748671002045 NAD(P) binding site [chemical binding]; other site 748671002046 active site 748671002047 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 748671002048 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748671002049 non-specific DNA binding site [nucleotide binding]; other site 748671002050 salt bridge; other site 748671002051 sequence-specific DNA binding site [nucleotide binding]; other site 748671002052 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 748671002053 recombinase A; Provisional; Region: recA; PRK09354 748671002054 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 748671002055 hexamer interface [polypeptide binding]; other site 748671002056 Walker A motif; other site 748671002057 ATP binding site [chemical binding]; other site 748671002058 Walker B motif; other site 748671002059 phosphodiesterase; Provisional; Region: PRK12704 748671002060 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748671002061 Zn2+ binding site [ion binding]; other site 748671002062 Mg2+ binding site [ion binding]; other site 748671002063 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 748671002064 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 748671002065 Mg++ binding site [ion binding]; other site 748671002066 putative catalytic motif [active] 748671002067 substrate binding site [chemical binding]; other site 748671002068 Uncharacterized conserved protein [Function unknown]; Region: COG1739 748671002069 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 748671002070 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 748671002071 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 748671002072 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748671002073 ATP binding site [chemical binding]; other site 748671002074 putative Mg++ binding site [ion binding]; other site 748671002075 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748671002076 nucleotide binding region [chemical binding]; other site 748671002077 ATP-binding site [chemical binding]; other site 748671002078 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 748671002079 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748671002080 active site 748671002081 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 748671002082 30S subunit binding site; other site 748671002083 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 748671002084 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 748671002085 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748671002086 nucleotide binding region [chemical binding]; other site 748671002087 ATP-binding site [chemical binding]; other site 748671002088 peptide chain release factor 2; Provisional; Region: PRK05589 748671002089 This domain is found in peptide chain release factors; Region: PCRF; smart00937 748671002090 RF-1 domain; Region: RF-1; pfam00472 748671002091 HPr kinase/phosphorylase; Provisional; Region: PRK05428 748671002092 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 748671002093 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 748671002094 Hpr binding site; other site 748671002095 active site 748671002096 homohexamer subunit interaction site [polypeptide binding]; other site 748671002097 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 748671002098 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 748671002099 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 748671002100 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 748671002101 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 748671002102 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 748671002103 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748671002104 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 748671002105 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 748671002106 active site 748671002107 substrate binding site [chemical binding]; other site 748671002108 metal binding site [ion binding]; metal-binding site 748671002109 excinuclease ABC subunit B; Provisional; Region: PRK05298 748671002110 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 748671002111 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748671002112 ATP-binding site [chemical binding]; other site 748671002113 ATP binding site [chemical binding]; other site 748671002114 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748671002115 nucleotide binding region [chemical binding]; other site 748671002116 ATP-binding site [chemical binding]; other site 748671002117 Ultra-violet resistance protein B; Region: UvrB; pfam12344 748671002118 UvrB/uvrC motif; Region: UVR; pfam02151 748671002119 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 748671002120 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 748671002121 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 748671002122 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 748671002123 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 748671002124 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 748671002125 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 748671002126 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 748671002127 putative substrate binding pocket [chemical binding]; other site 748671002128 dimer interface [polypeptide binding]; other site 748671002129 phosphate binding site [ion binding]; other site 748671002130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 748671002131 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 748671002132 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 748671002133 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 748671002134 oligomer interface [polypeptide binding]; other site 748671002135 active site residues [active] 748671002136 SH3-like domain; Region: SH3_8; pfam13457 748671002137 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 748671002138 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 748671002139 Walker A/P-loop; other site 748671002140 ATP binding site [chemical binding]; other site 748671002141 Q-loop/lid; other site 748671002142 ABC transporter signature motif; other site 748671002143 Walker B; other site 748671002144 D-loop; other site 748671002145 H-loop/switch region; other site 748671002146 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 748671002147 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 748671002148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748671002149 putative substrate translocation pore; other site 748671002150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748671002151 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 748671002152 DNA binding residues [nucleotide binding] 748671002153 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 748671002154 putative dimer interface [polypeptide binding]; other site 748671002155 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 748671002156 Amino acid permease; Region: AA_permease_2; pfam13520 748671002157 Predicted transcriptional regulator [Transcription]; Region: COG3388 748671002158 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 748671002159 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 748671002160 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 748671002161 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 748671002162 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 748671002163 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 748671002164 Phosphoglycerate kinase; Region: PGK; pfam00162 748671002165 substrate binding site [chemical binding]; other site 748671002166 hinge regions; other site 748671002167 ADP binding site [chemical binding]; other site 748671002168 catalytic site [active] 748671002169 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 748671002170 triosephosphate isomerase; Provisional; Region: PRK14567 748671002171 substrate binding site [chemical binding]; other site 748671002172 dimer interface [polypeptide binding]; other site 748671002173 catalytic triad [active] 748671002174 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 748671002175 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 748671002176 active site 748671002177 motif I; other site 748671002178 motif II; other site 748671002179 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748671002180 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 748671002181 ligand binding site [chemical binding]; other site 748671002182 active site 748671002183 UGI interface [polypeptide binding]; other site 748671002184 catalytic site [active] 748671002185 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 748671002186 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 748671002187 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 748671002188 active site 748671002189 catalytic site [active] 748671002190 substrate binding site [chemical binding]; other site 748671002191 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 748671002192 FAD binding domain; Region: FAD_binding_4; pfam01565 748671002193 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 748671002194 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 748671002195 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 748671002196 Walker A/P-loop; other site 748671002197 ATP binding site [chemical binding]; other site 748671002198 Q-loop/lid; other site 748671002199 ABC transporter signature motif; other site 748671002200 Walker B; other site 748671002201 D-loop; other site 748671002202 H-loop/switch region; other site 748671002203 TOBE domain; Region: TOBE_2; pfam08402 748671002204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748671002205 dimer interface [polypeptide binding]; other site 748671002206 conserved gate region; other site 748671002207 putative PBP binding loops; other site 748671002208 ABC-ATPase subunit interface; other site 748671002209 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 748671002210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748671002211 dimer interface [polypeptide binding]; other site 748671002212 conserved gate region; other site 748671002213 putative PBP binding loops; other site 748671002214 ABC-ATPase subunit interface; other site 748671002215 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 748671002216 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 748671002217 Uncharacterized conserved protein [Function unknown]; Region: COG1624 748671002218 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 748671002219 YbbR-like protein; Region: YbbR; pfam07949 748671002220 YbbR-like protein; Region: YbbR; pfam07949 748671002221 YbbR-like protein; Region: YbbR; pfam07949 748671002222 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 748671002223 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 748671002224 active site 748671002225 substrate binding site [chemical binding]; other site 748671002226 metal binding site [ion binding]; metal-binding site 748671002227 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 748671002228 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748671002229 active site 748671002230 motif I; other site 748671002231 motif II; other site 748671002232 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 748671002233 Penicillinase repressor; Region: Pencillinase_R; pfam03965 748671002234 clostripain; Region: clostrip; TIGR02806 748671002235 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 748671002236 Low molecular weight phosphatase family; Region: LMWPc; cd00115 748671002237 active site 748671002238 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 748671002239 transcriptional antiterminator BglG; Provisional; Region: PRK09772 748671002240 CAT RNA binding domain; Region: CAT_RBD; smart01061 748671002241 PRD domain; Region: PRD; pfam00874 748671002242 PRD domain; Region: PRD; pfam00874 748671002243 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 748671002244 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 748671002245 active site turn [active] 748671002246 phosphorylation site [posttranslational modification] 748671002247 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 748671002248 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 748671002249 HPr interaction site; other site 748671002250 glycerol kinase (GK) interaction site [polypeptide binding]; other site 748671002251 active site 748671002252 phosphorylation site [posttranslational modification] 748671002253 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 748671002254 beta-galactosidase; Region: BGL; TIGR03356 748671002255 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 748671002256 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 748671002257 Amino acid permease; Region: AA_permease_2; pfam13520 748671002258 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 748671002259 NADH(P)-binding; Region: NAD_binding_10; pfam13460 748671002260 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 748671002261 NAD(P) binding site [chemical binding]; other site 748671002262 active site 748671002263 Predicted integral membrane protein [Function unknown]; Region: COG5652 748671002264 hypothetical protein; Validated; Region: PRK00110 748671002265 Type II/IV secretion system protein; Region: T2SE; pfam00437 748671002266 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 748671002267 Walker A motif; other site 748671002268 ATP binding site [chemical binding]; other site 748671002269 Walker B motif; other site 748671002270 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 748671002271 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 748671002272 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 748671002273 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 748671002274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748671002275 S-adenosylmethionine binding site [chemical binding]; other site 748671002276 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 748671002277 propionate/acetate kinase; Provisional; Region: PRK12379 748671002278 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 748671002279 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 748671002280 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748671002281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748671002282 homodimer interface [polypeptide binding]; other site 748671002283 catalytic residue [active] 748671002284 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 748671002285 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 748671002286 SdpI/YhfL protein family; Region: SdpI; pfam13630 748671002287 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748671002288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748671002289 active site 748671002290 phosphorylation site [posttranslational modification] 748671002291 intermolecular recognition site; other site 748671002292 dimerization interface [polypeptide binding]; other site 748671002293 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748671002294 DNA binding site [nucleotide binding] 748671002295 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748671002296 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748671002297 dimerization interface [polypeptide binding]; other site 748671002298 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748671002299 dimer interface [polypeptide binding]; other site 748671002300 phosphorylation site [posttranslational modification] 748671002301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748671002302 ATP binding site [chemical binding]; other site 748671002303 Mg2+ binding site [ion binding]; other site 748671002304 G-X-G motif; other site 748671002305 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 748671002306 Sulfatase; Region: Sulfatase; pfam00884 748671002307 VanZ like family; Region: VanZ; pfam04892 748671002308 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 748671002309 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 748671002310 active site 748671002311 dimer interface [polypeptide binding]; other site 748671002312 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 748671002313 dimer interface [polypeptide binding]; other site 748671002314 active site 748671002315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748671002316 putative substrate translocation pore; other site 748671002317 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 748671002318 Beta-lactamase; Region: Beta-lactamase; pfam00144 748671002319 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 748671002320 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 748671002321 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 748671002322 thymidine kinase; Provisional; Region: PRK04296 748671002323 peptide chain release factor 1; Validated; Region: prfA; PRK00591 748671002324 This domain is found in peptide chain release factors; Region: PCRF; smart00937 748671002325 RF-1 domain; Region: RF-1; pfam00472 748671002326 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 748671002327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748671002328 S-adenosylmethionine binding site [chemical binding]; other site 748671002329 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 748671002330 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 748671002331 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748671002332 active site 748671002333 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 748671002334 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 748671002335 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 748671002336 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 748671002337 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 748671002338 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 748671002339 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 748671002340 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 748671002341 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 748671002342 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 748671002343 beta subunit interaction interface [polypeptide binding]; other site 748671002344 Walker A motif; other site 748671002345 ATP binding site [chemical binding]; other site 748671002346 Walker B motif; other site 748671002347 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 748671002348 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 748671002349 core domain interface [polypeptide binding]; other site 748671002350 delta subunit interface [polypeptide binding]; other site 748671002351 epsilon subunit interface [polypeptide binding]; other site 748671002352 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 748671002353 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 748671002354 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 748671002355 alpha subunit interaction interface [polypeptide binding]; other site 748671002356 Walker A motif; other site 748671002357 ATP binding site [chemical binding]; other site 748671002358 Walker B motif; other site 748671002359 inhibitor binding site; inhibition site 748671002360 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 748671002361 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 748671002362 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 748671002363 gamma subunit interface [polypeptide binding]; other site 748671002364 epsilon subunit interface [polypeptide binding]; other site 748671002365 LBP interface [polypeptide binding]; other site 748671002366 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 748671002367 rod shape-determining protein MreB; Provisional; Region: PRK13930 748671002368 MreB and similar proteins; Region: MreB_like; cd10225 748671002369 nucleotide binding site [chemical binding]; other site 748671002370 Mg binding site [ion binding]; other site 748671002371 putative protofilament interaction site [polypeptide binding]; other site 748671002372 RodZ interaction site [polypeptide binding]; other site 748671002373 hypothetical protein; Provisional; Region: PRK14379 748671002374 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 748671002375 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 748671002376 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 748671002377 Ligand Binding Site [chemical binding]; other site 748671002378 recombination factor protein RarA; Reviewed; Region: PRK13342 748671002379 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748671002380 Walker A motif; other site 748671002381 ATP binding site [chemical binding]; other site 748671002382 Walker B motif; other site 748671002383 arginine finger; other site 748671002384 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 748671002385 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 748671002386 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 748671002387 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 748671002388 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 748671002389 RNA binding surface [nucleotide binding]; other site 748671002390 septation ring formation regulator EzrA; Provisional; Region: PRK04778 748671002391 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 748671002392 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 748671002393 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 748671002394 catalytic residue [active] 748671002395 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 748671002396 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 748671002397 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 748671002398 Ligand Binding Site [chemical binding]; other site 748671002399 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 748671002400 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 748671002401 RNA binding surface [nucleotide binding]; other site 748671002402 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 748671002403 active site 748671002404 uracil binding [chemical binding]; other site 748671002405 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748671002406 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748671002407 non-specific DNA binding site [nucleotide binding]; other site 748671002408 salt bridge; other site 748671002409 sequence-specific DNA binding site [nucleotide binding]; other site 748671002410 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748671002411 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748671002412 non-specific DNA binding site [nucleotide binding]; other site 748671002413 salt bridge; other site 748671002414 sequence-specific DNA binding site [nucleotide binding]; other site 748671002415 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 748671002416 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748671002417 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748671002418 non-specific DNA binding site [nucleotide binding]; other site 748671002419 salt bridge; other site 748671002420 sequence-specific DNA binding site [nucleotide binding]; other site 748671002421 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 748671002422 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 748671002423 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 748671002424 Bacterial surface layer protein; Region: SLAP; pfam03217 748671002425 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 748671002426 Transposase; Region: DDE_Tnp_ISL3; pfam01610 748671002427 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 748671002428 Transposase; Region: DDE_Tnp_ISL3; pfam01610 748671002429 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 748671002430 Bacterial surface layer protein; Region: SLAP; pfam03217 748671002431 Protein of unknown function (DUF3232); Region: DUF3232; pfam11554 748671002432 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748671002433 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748671002434 non-specific DNA binding site [nucleotide binding]; other site 748671002435 salt bridge; other site 748671002436 sequence-specific DNA binding site [nucleotide binding]; other site 748671002437 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 748671002438 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 748671002439 RNA binding surface [nucleotide binding]; other site 748671002440 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 748671002441 active site 748671002442 uracil binding [chemical binding]; other site 748671002443 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 748671002444 Predicted membrane protein [Function unknown]; Region: COG2246 748671002445 GtrA-like protein; Region: GtrA; pfam04138 748671002446 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 748671002447 Ligand binding site; other site 748671002448 Putative Catalytic site; other site 748671002449 DXD motif; other site 748671002450 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 748671002451 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 748671002452 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 748671002453 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 748671002454 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 748671002455 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748671002456 motif II; other site 748671002457 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 748671002458 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 748671002459 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 748671002460 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748671002461 salt bridge; other site 748671002462 non-specific DNA binding site [nucleotide binding]; other site 748671002463 sequence-specific DNA binding site [nucleotide binding]; other site 748671002464 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 748671002465 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 748671002466 active site 748671002467 HIGH motif; other site 748671002468 nucleotide binding site [chemical binding]; other site 748671002469 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 748671002470 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 748671002471 active site 748671002472 KMSKS motif; other site 748671002473 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 748671002474 tRNA binding surface [nucleotide binding]; other site 748671002475 anticodon binding site; other site 748671002476 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 748671002477 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 748671002478 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 748671002479 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 748671002480 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 748671002481 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748671002482 motif II; other site 748671002483 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 748671002484 MPN+ (JAMM) motif; other site 748671002485 Zinc-binding site [ion binding]; other site 748671002486 rod shape-determining protein MreB; Provisional; Region: PRK13927 748671002487 MreB and similar proteins; Region: MreB_like; cd10225 748671002488 nucleotide binding site [chemical binding]; other site 748671002489 Mg binding site [ion binding]; other site 748671002490 putative protofilament interaction site [polypeptide binding]; other site 748671002491 RodZ interaction site [polypeptide binding]; other site 748671002492 rod shape-determining protein MreC; Provisional; Region: PRK13922 748671002493 rod shape-determining protein MreC; Region: MreC; pfam04085 748671002494 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 748671002495 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 748671002496 cell division protein MraZ; Reviewed; Region: PRK00326 748671002497 MraZ protein; Region: MraZ; pfam02381 748671002498 MraZ protein; Region: MraZ; pfam02381 748671002499 MraW methylase family; Region: Methyltransf_5; pfam01795 748671002500 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 748671002501 Cell division protein FtsL; Region: FtsL; cl11433 748671002502 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 748671002503 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 748671002504 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 748671002505 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 748671002506 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 748671002507 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 748671002508 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 748671002509 Mg++ binding site [ion binding]; other site 748671002510 putative catalytic motif [active] 748671002511 putative substrate binding site [chemical binding]; other site 748671002512 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 748671002513 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 748671002514 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 748671002515 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 748671002516 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 748671002517 active site 748671002518 homodimer interface [polypeptide binding]; other site 748671002519 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 748671002520 Cell division protein FtsQ; Region: FtsQ; pfam03799 748671002521 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 748671002522 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 748671002523 nucleotide binding site [chemical binding]; other site 748671002524 Cell division protein FtsA; Region: FtsA; cl17206 748671002525 Cell division protein FtsA; Region: FtsA; pfam14450 748671002526 cell division protein FtsZ; Validated; Region: PRK09330 748671002527 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 748671002528 nucleotide binding site [chemical binding]; other site 748671002529 SulA interaction site; other site 748671002530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 748671002531 YGGT family; Region: YGGT; pfam02325 748671002532 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 748671002533 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 748671002534 RNA binding surface [nucleotide binding]; other site 748671002535 DivIVA protein; Region: DivIVA; pfam05103 748671002536 DivIVA domain; Region: DivI1A_domain; TIGR03544 748671002537 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 748671002538 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 748671002539 active site 748671002540 HIGH motif; other site 748671002541 nucleotide binding site [chemical binding]; other site 748671002542 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 748671002543 active site 748671002544 KMSKS motif; other site 748671002545 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 748671002546 tRNA binding surface [nucleotide binding]; other site 748671002547 anticodon binding site; other site 748671002548 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 748671002549 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 748671002550 DNA-binding site [nucleotide binding]; DNA binding site 748671002551 RNA-binding motif; other site 748671002552 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 748671002553 dimer interface [polypeptide binding]; other site 748671002554 ADP-ribose binding site [chemical binding]; other site 748671002555 active site 748671002556 nudix motif; other site 748671002557 metal binding site [ion binding]; metal-binding site 748671002558 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 748671002559 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 748671002560 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 748671002561 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 748671002562 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 748671002563 catalytic residue [active] 748671002564 Putative amino acid metabolism; Region: DUF1831; pfam08866 748671002565 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 748671002566 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 748671002567 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 748671002568 catalytic core [active] 748671002569 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748671002570 binding surface 748671002571 TPR motif; other site 748671002572 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 748671002573 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 748671002574 AAA domain; Region: AAA_30; pfam13604 748671002575 Family description; Region: UvrD_C_2; pfam13538 748671002576 Nuclease-related domain; Region: NERD; pfam08378 748671002577 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 748671002578 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 748671002579 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 748671002580 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 748671002581 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 748671002582 hypothetical protein; Provisional; Region: PRK13667 748671002583 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 748671002584 active site 748671002585 catalytic residues [active] 748671002586 metal binding site [ion binding]; metal-binding site 748671002587 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 748671002588 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 748671002589 G1 box; other site 748671002590 putative GEF interaction site [polypeptide binding]; other site 748671002591 GTP/Mg2+ binding site [chemical binding]; other site 748671002592 Switch I region; other site 748671002593 G2 box; other site 748671002594 G3 box; other site 748671002595 Switch II region; other site 748671002596 G4 box; other site 748671002597 G5 box; other site 748671002598 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 748671002599 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 748671002600 cell division protein FtsW; Region: ftsW; TIGR02614 748671002601 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 748671002602 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 748671002603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748671002604 S-adenosylmethionine binding site [chemical binding]; other site 748671002605 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 748671002606 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 748671002607 active site 748671002608 (T/H)XGH motif; other site 748671002609 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 748671002610 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 748671002611 SLBB domain; Region: SLBB; pfam10531 748671002612 comEA protein; Region: comE; TIGR01259 748671002613 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 748671002614 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 748671002615 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 748671002616 Competence protein; Region: Competence; pfam03772 748671002617 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 748671002618 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 748671002619 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 748671002620 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 748671002621 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 748671002622 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 748671002623 16S/18S rRNA binding site [nucleotide binding]; other site 748671002624 S13e-L30e interaction site [polypeptide binding]; other site 748671002625 25S rRNA binding site [nucleotide binding]; other site 748671002626 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 748671002627 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 748671002628 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 748671002629 elongation factor Tu; Reviewed; Region: PRK00049 748671002630 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 748671002631 G1 box; other site 748671002632 GEF interaction site [polypeptide binding]; other site 748671002633 GTP/Mg2+ binding site [chemical binding]; other site 748671002634 Switch I region; other site 748671002635 G2 box; other site 748671002636 G3 box; other site 748671002637 Switch II region; other site 748671002638 G4 box; other site 748671002639 G5 box; other site 748671002640 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 748671002641 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 748671002642 Antibiotic Binding Site [chemical binding]; other site 748671002643 trigger factor; Provisional; Region: tig; PRK01490 748671002644 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 748671002645 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 748671002646 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 748671002647 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 748671002648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748671002649 Walker A motif; other site 748671002650 ATP binding site [chemical binding]; other site 748671002651 Walker B motif; other site 748671002652 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 748671002653 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 748671002654 G1 box; other site 748671002655 GTP/Mg2+ binding site [chemical binding]; other site 748671002656 Switch I region; other site 748671002657 G2 box; other site 748671002658 G3 box; other site 748671002659 Switch II region; other site 748671002660 G4 box; other site 748671002661 G5 box; other site 748671002662 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 748671002663 inner membrane transporter YjeM; Provisional; Region: PRK15238 748671002664 inner membrane transporter YjeM; Provisional; Region: PRK15238 748671002665 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 748671002666 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 748671002667 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 748671002668 aspartate kinase; Reviewed; Region: PRK09034 748671002669 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 748671002670 putative catalytic residues [active] 748671002671 putative nucleotide binding site [chemical binding]; other site 748671002672 putative aspartate binding site [chemical binding]; other site 748671002673 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 748671002674 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 748671002675 diaminopimelate decarboxylase; Region: lysA; TIGR01048 748671002676 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 748671002677 active site 748671002678 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 748671002679 substrate binding site [chemical binding]; other site 748671002680 catalytic residues [active] 748671002681 dimer interface [polypeptide binding]; other site 748671002682 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 748671002683 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 748671002684 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 748671002685 putative trimer interface [polypeptide binding]; other site 748671002686 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 748671002687 putative CoA binding site [chemical binding]; other site 748671002688 putative trimer interface [polypeptide binding]; other site 748671002689 putative CoA binding site [chemical binding]; other site 748671002690 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 748671002691 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 748671002692 metal binding site [ion binding]; metal-binding site 748671002693 putative dimer interface [polypeptide binding]; other site 748671002694 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 748671002695 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 748671002696 dimer interface [polypeptide binding]; other site 748671002697 active site 748671002698 catalytic residue [active] 748671002699 dihydrodipicolinate reductase; Provisional; Region: PRK00048 748671002700 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 748671002701 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 748671002702 aromatic amino acid aminotransferase; Validated; Region: PRK07309 748671002703 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748671002704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748671002705 homodimer interface [polypeptide binding]; other site 748671002706 catalytic residue [active] 748671002707 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 748671002708 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 748671002709 Beta-lactamase; Region: Beta-lactamase; pfam00144 748671002710 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 748671002711 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 748671002712 nucleophilic elbow; other site 748671002713 catalytic triad; other site 748671002714 FMN-binding domain; Region: FMN_bind; pfam04205 748671002715 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 748671002716 active site 748671002717 dimerization interface [polypeptide binding]; other site 748671002718 A new structural DNA glycosylase; Region: AlkD_like; cl11434 748671002719 A new structural DNA glycosylase; Region: AlkD_like; cl11434 748671002720 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 748671002721 active site 748671002722 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 748671002723 beta-galactosidase; Region: BGL; TIGR03356 748671002724 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 748671002725 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748671002726 DNA-binding site [nucleotide binding]; DNA binding site 748671002727 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 748671002728 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 748671002729 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 748671002730 active site 748671002731 P-loop; other site 748671002732 phosphorylation site [posttranslational modification] 748671002733 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 748671002734 active site 748671002735 methionine cluster; other site 748671002736 phosphorylation site [posttranslational modification] 748671002737 metal binding site [ion binding]; metal-binding site 748671002738 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 748671002739 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 748671002740 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 748671002741 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 748671002742 beta-galactosidase; Region: BGL; TIGR03356 748671002743 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 748671002744 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748671002745 DNA-binding site [nucleotide binding]; DNA binding site 748671002746 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 748671002747 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 748671002748 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 748671002749 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 748671002750 beta-galactosidase; Region: BGL; TIGR03356 748671002751 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 748671002752 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 748671002753 nucleotide binding site [chemical binding]; other site 748671002754 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 748671002755 FMN binding site [chemical binding]; other site 748671002756 dimer interface [polypeptide binding]; other site 748671002757 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 748671002758 enolase; Provisional; Region: eno; PRK00077 748671002759 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 748671002760 dimer interface [polypeptide binding]; other site 748671002761 metal binding site [ion binding]; metal-binding site 748671002762 substrate binding pocket [chemical binding]; other site 748671002763 EDD domain protein, DegV family; Region: DegV; TIGR00762 748671002764 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 748671002765 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 748671002766 active site 748671002767 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 748671002768 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 748671002769 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 748671002770 active site 748671002771 Predicted membrane protein [Function unknown]; Region: COG2855 748671002772 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 748671002773 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 748671002774 dimerization interface [polypeptide binding]; other site 748671002775 DPS ferroxidase diiron center [ion binding]; other site 748671002776 ion pore; other site 748671002777 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 748671002778 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 748671002779 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748671002780 motif II; other site 748671002781 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 748671002782 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 748671002783 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 748671002784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748671002785 Coenzyme A binding pocket [chemical binding]; other site 748671002786 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 748671002787 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 748671002788 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 748671002789 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 748671002790 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 748671002791 MucBP domain; Region: MucBP; pfam06458 748671002792 MucBP domain; Region: MucBP; pfam06458 748671002793 MucBP domain; Region: MucBP; pfam06458 748671002794 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 748671002795 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 748671002796 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 748671002797 DXD motif; other site 748671002798 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 748671002799 Helix-turn-helix domain; Region: HTH_38; pfam13936 748671002800 DNA-binding interface [nucleotide binding]; DNA binding site 748671002801 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 748671002802 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 748671002803 putative active site [active] 748671002804 putative NTP binding site [chemical binding]; other site 748671002805 putative nucleic acid binding site [nucleotide binding]; other site 748671002806 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 748671002807 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 748671002808 homopentamer interface [polypeptide binding]; other site 748671002809 active site 748671002810 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 748671002811 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 748671002812 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 748671002813 dimerization interface [polypeptide binding]; other site 748671002814 active site 748671002815 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 748671002816 Lumazine binding domain; Region: Lum_binding; pfam00677 748671002817 Lumazine binding domain; Region: Lum_binding; pfam00677 748671002818 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 748671002819 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 748671002820 catalytic motif [active] 748671002821 Zn binding site [ion binding]; other site 748671002822 RibD C-terminal domain; Region: RibD_C; cl17279 748671002823 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 748671002824 classical (c) SDRs; Region: SDR_c; cd05233 748671002825 NAD(P) binding site [chemical binding]; other site 748671002826 active site 748671002827 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 748671002828 LytTr DNA-binding domain; Region: LytTR; smart00850 748671002829 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748671002830 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 748671002831 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 748671002832 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 748671002833 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 748671002834 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 748671002835 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 748671002836 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 748671002837 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 748671002838 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 748671002839 nudix motif; other site 748671002840 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 748671002841 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 748671002842 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 748671002843 dimer interface [polypeptide binding]; other site 748671002844 catalytic triad [active] 748671002845 peroxidatic and resolving cysteines [active] 748671002846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748671002847 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 748671002848 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 748671002849 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 748671002850 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748671002851 Coenzyme A binding pocket [chemical binding]; other site 748671002852 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 748671002853 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786 748671002854 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748671002855 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748671002856 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 748671002857 Walker A/P-loop; other site 748671002858 ATP binding site [chemical binding]; other site 748671002859 Q-loop/lid; other site 748671002860 ABC transporter signature motif; other site 748671002861 Walker B; other site 748671002862 D-loop; other site 748671002863 H-loop/switch region; other site 748671002864 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748671002865 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748671002866 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 748671002867 Walker A/P-loop; other site 748671002868 ATP binding site [chemical binding]; other site 748671002869 Q-loop/lid; other site 748671002870 ABC transporter signature motif; other site 748671002871 Walker B; other site 748671002872 D-loop; other site 748671002873 H-loop/switch region; other site 748671002874 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 748671002875 thymidylate synthase; Region: thym_sym; TIGR03284 748671002876 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 748671002877 dimerization interface [polypeptide binding]; other site 748671002878 active site 748671002879 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 748671002880 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 748671002881 folate binding site [chemical binding]; other site 748671002882 NADP+ binding site [chemical binding]; other site 748671002883 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 748671002884 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 748671002885 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748671002886 motif II; other site 748671002887 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 748671002888 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 748671002889 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 748671002890 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 748671002891 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 748671002892 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 748671002893 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 748671002894 Walker A/P-loop; other site 748671002895 ATP binding site [chemical binding]; other site 748671002896 Q-loop/lid; other site 748671002897 ABC transporter signature motif; other site 748671002898 Walker B; other site 748671002899 D-loop; other site 748671002900 H-loop/switch region; other site 748671002901 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 748671002902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748671002903 dimer interface [polypeptide binding]; other site 748671002904 conserved gate region; other site 748671002905 ABC-ATPase subunit interface; other site 748671002906 fumarate hydratase; Reviewed; Region: fumC; PRK00485 748671002907 Class II fumarases; Region: Fumarase_classII; cd01362 748671002908 active site 748671002909 tetramer interface [polypeptide binding]; other site 748671002910 L-aspartate oxidase; Provisional; Region: PRK06175 748671002911 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 748671002912 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 748671002913 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 748671002914 tetramer (dimer of dimers) interface [polypeptide binding]; other site 748671002915 NAD binding site [chemical binding]; other site 748671002916 dimer interface [polypeptide binding]; other site 748671002917 substrate binding site [chemical binding]; other site 748671002918 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 748671002919 trimer interface [polypeptide binding]; other site 748671002920 active site 748671002921 G bulge; other site 748671002922 hypothetical protein; Validated; Region: PRK06201 748671002923 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 748671002924 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 748671002925 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 748671002926 transmembrane helices; other site 748671002927 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 748671002928 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 748671002929 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 748671002930 putative active site [active] 748671002931 (T/H)XGH motif; other site 748671002932 citrate lyase subunit gamma; Provisional; Region: PRK13253 748671002933 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 748671002934 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 748671002935 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 748671002936 Protein of unknown function (DUF441); Region: DUF441; pfam04284 748671002937 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 748671002938 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 748671002939 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 748671002940 Walker A/P-loop; other site 748671002941 ATP binding site [chemical binding]; other site 748671002942 Q-loop/lid; other site 748671002943 ABC transporter signature motif; other site 748671002944 Walker B; other site 748671002945 D-loop; other site 748671002946 H-loop/switch region; other site 748671002947 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 748671002948 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 748671002949 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 748671002950 Walker A/P-loop; other site 748671002951 ATP binding site [chemical binding]; other site 748671002952 Q-loop/lid; other site 748671002953 ABC transporter signature motif; other site 748671002954 Walker B; other site 748671002955 D-loop; other site 748671002956 H-loop/switch region; other site 748671002957 hypothetical protein; Provisional; Region: PRK13661 748671002958 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 748671002959 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 748671002960 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 748671002961 Uncharacterized conserved protein [Function unknown]; Region: COG2966 748671002962 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 748671002963 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 748671002964 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 748671002965 putative deacylase active site [active] 748671002966 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 748671002967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748671002968 S-adenosylmethionine binding site [chemical binding]; other site 748671002969 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 748671002970 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748671002971 Zn2+ binding site [ion binding]; other site 748671002972 Mg2+ binding site [ion binding]; other site 748671002973 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 748671002974 synthetase active site [active] 748671002975 NTP binding site [chemical binding]; other site 748671002976 metal binding site [ion binding]; metal-binding site 748671002977 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 748671002978 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 748671002979 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 748671002980 putative active site [active] 748671002981 dimerization interface [polypeptide binding]; other site 748671002982 putative tRNAtyr binding site [nucleotide binding]; other site 748671002983 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 748671002984 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 748671002985 dimer interface [polypeptide binding]; other site 748671002986 motif 1; other site 748671002987 active site 748671002988 motif 2; other site 748671002989 motif 3; other site 748671002990 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 748671002991 anticodon binding site; other site 748671002992 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 748671002993 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 748671002994 dimer interface [polypeptide binding]; other site 748671002995 anticodon binding site; other site 748671002996 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 748671002997 homodimer interface [polypeptide binding]; other site 748671002998 motif 1; other site 748671002999 active site 748671003000 motif 2; other site 748671003001 GAD domain; Region: GAD; pfam02938 748671003002 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 748671003003 active site 748671003004 motif 3; other site 748671003005 aromatic amino acid aminotransferase; Validated; Region: PRK07309 748671003006 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748671003007 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748671003008 homodimer interface [polypeptide binding]; other site 748671003009 catalytic residue [active] 748671003010 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 748671003011 Flavoprotein; Region: Flavoprotein; pfam02441 748671003012 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 748671003013 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 748671003014 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 748671003015 active site 748671003016 catalytic tetrad [active] 748671003017 sugar phosphate phosphatase; Provisional; Region: PRK10513 748671003018 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748671003019 active site 748671003020 motif I; other site 748671003021 motif II; other site 748671003022 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 748671003023 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 748671003024 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 748671003025 putative ligand binding site [chemical binding]; other site 748671003026 putative NAD binding site [chemical binding]; other site 748671003027 catalytic site [active] 748671003028 amino acid transporter; Region: 2A0306; TIGR00909 748671003029 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 748671003030 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 748671003031 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 748671003032 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 748671003033 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 748671003034 GIY-YIG motif/motif A; other site 748671003035 active site 748671003036 catalytic site [active] 748671003037 putative DNA binding site [nucleotide binding]; other site 748671003038 metal binding site [ion binding]; metal-binding site 748671003039 UvrB/uvrC motif; Region: UVR; pfam02151 748671003040 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 748671003041 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 748671003042 DNA binding site [nucleotide binding] 748671003043 GTPase CgtA; Reviewed; Region: obgE; PRK12297 748671003044 GTP1/OBG; Region: GTP1_OBG; pfam01018 748671003045 Obg GTPase; Region: Obg; cd01898 748671003046 G1 box; other site 748671003047 GTP/Mg2+ binding site [chemical binding]; other site 748671003048 Switch I region; other site 748671003049 G2 box; other site 748671003050 G3 box; other site 748671003051 Switch II region; other site 748671003052 G4 box; other site 748671003053 G5 box; other site 748671003054 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 748671003055 Acyltransferase family; Region: Acyl_transf_3; pfam01757 748671003056 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 748671003057 catalytic triad [active] 748671003058 oxyanion hole [active] 748671003059 catalytic triad [active] 748671003060 ribonuclease Z; Region: RNase_Z; TIGR02651 748671003061 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 748671003062 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 748671003063 NAD(P) binding site [chemical binding]; other site 748671003064 active site 748671003065 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 748671003066 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 748671003067 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 748671003068 active site 748671003069 metal binding site [ion binding]; metal-binding site 748671003070 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 748671003071 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 748671003072 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 748671003073 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 748671003074 active site 748671003075 PHP Thumb interface [polypeptide binding]; other site 748671003076 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 748671003077 generic binding surface I; other site 748671003078 generic binding surface II; other site 748671003079 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 748671003080 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 748671003081 active site 748671003082 ADP/pyrophosphate binding site [chemical binding]; other site 748671003083 dimerization interface [polypeptide binding]; other site 748671003084 allosteric effector site; other site 748671003085 fructose-1,6-bisphosphate binding site; other site 748671003086 pyruvate kinase; Provisional; Region: PRK06354 748671003087 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 748671003088 domain interfaces; other site 748671003089 active site 748671003090 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 748671003091 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 748671003092 S1 domain; Region: S1_2; pfam13509 748671003093 MarR family; Region: MarR_2; cl17246 748671003094 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 748671003095 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 748671003096 active site 748671003097 Int/Topo IB signature motif; other site 748671003098 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 748671003099 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 748671003100 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 748671003101 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 748671003102 RNA binding surface [nucleotide binding]; other site 748671003103 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 748671003104 active site 748671003105 Predicted membrane protein [Function unknown]; Region: COG3601 748671003106 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 748671003107 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 748671003108 cytidylate kinase; Provisional; Region: cmk; PRK00023 748671003109 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 748671003110 CMP-binding site; other site 748671003111 The sites determining sugar specificity; other site 748671003112 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 748671003113 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 748671003114 RNA binding site [nucleotide binding]; other site 748671003115 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 748671003116 RNA binding site [nucleotide binding]; other site 748671003117 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 748671003118 RNA binding site [nucleotide binding]; other site 748671003119 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 748671003120 RNA binding site [nucleotide binding]; other site 748671003121 GTP-binding protein Der; Reviewed; Region: PRK00093 748671003122 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 748671003123 G1 box; other site 748671003124 GTP/Mg2+ binding site [chemical binding]; other site 748671003125 Switch I region; other site 748671003126 G2 box; other site 748671003127 Switch II region; other site 748671003128 G3 box; other site 748671003129 G4 box; other site 748671003130 G5 box; other site 748671003131 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 748671003132 G1 box; other site 748671003133 GTP/Mg2+ binding site [chemical binding]; other site 748671003134 Switch I region; other site 748671003135 G2 box; other site 748671003136 G3 box; other site 748671003137 Switch II region; other site 748671003138 G4 box; other site 748671003139 G5 box; other site 748671003140 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 748671003141 IHF dimer interface [polypeptide binding]; other site 748671003142 IHF - DNA interface [nucleotide binding]; other site 748671003143 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748671003144 TPR motif; other site 748671003145 binding surface 748671003146 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 748671003147 binding surface 748671003148 TPR motif; other site 748671003149 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 748671003150 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 748671003151 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 748671003152 putative active site [active] 748671003153 catalytic site [active] 748671003154 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 748671003155 putative active site [active] 748671003156 catalytic site [active] 748671003157 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748671003158 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748671003159 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 748671003160 Walker A/P-loop; other site 748671003161 ATP binding site [chemical binding]; other site 748671003162 Q-loop/lid; other site 748671003163 ABC transporter signature motif; other site 748671003164 Walker B; other site 748671003165 D-loop; other site 748671003166 H-loop/switch region; other site 748671003167 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 748671003168 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 748671003169 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 748671003170 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Sulfolobus solfataricus (Ss) and its homologs from archaea and bacteria; Region: NTP-PPase_SsMazG; cd11535 748671003171 metal binding site [ion binding]; metal-binding site 748671003172 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 748671003173 Glutaminase; Region: Glutaminase; cl00907 748671003174 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 748671003175 Interdomain contacts; other site 748671003176 Cytokine receptor motif; other site 748671003177 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 748671003178 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 748671003179 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 748671003180 PGAP1-like protein; Region: PGAP1; pfam07819 748671003181 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 748671003182 hypothetical protein; Provisional; Region: PRK06762 748671003183 AAA domain; Region: AAA_33; pfam13671 748671003184 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 748671003185 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 748671003186 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 748671003187 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 748671003188 amino acid transporter; Region: 2A0306; TIGR00909 748671003189 cationic amino acid transport permease; Region: 2A0303; TIGR00906 748671003190 Bacterial surface layer protein; Region: SLAP; pfam03217 748671003191 Uncharacterized conserved protein [Function unknown]; Region: COG1284 748671003192 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 748671003193 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 748671003194 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 748671003195 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 748671003196 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 748671003197 active site 748671003198 NTP binding site [chemical binding]; other site 748671003199 metal binding triad [ion binding]; metal-binding site 748671003200 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 748671003201 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 748671003202 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 748671003203 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 748671003204 EDD domain protein, DegV family; Region: DegV; TIGR00762 748671003205 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 748671003206 hypothetical protein; Provisional; Region: PRK13672 748671003207 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 748671003208 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 748671003209 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 748671003210 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 748671003211 GTP/Mg2+ binding site [chemical binding]; other site 748671003212 G4 box; other site 748671003213 G5 box; other site 748671003214 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 748671003215 G1 box; other site 748671003216 G1 box; other site 748671003217 GTP/Mg2+ binding site [chemical binding]; other site 748671003218 Switch I region; other site 748671003219 G2 box; other site 748671003220 G2 box; other site 748671003221 Switch I region; other site 748671003222 G3 box; other site 748671003223 G3 box; other site 748671003224 Switch II region; other site 748671003225 Switch II region; other site 748671003226 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 748671003227 RNA/DNA hybrid binding site [nucleotide binding]; other site 748671003228 active site 748671003229 DNA protecting protein DprA; Region: dprA; TIGR00732 748671003230 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 748671003231 DNA topoisomerase I; Validated; Region: PRK05582 748671003232 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 748671003233 active site 748671003234 interdomain interaction site; other site 748671003235 putative metal-binding site [ion binding]; other site 748671003236 nucleotide binding site [chemical binding]; other site 748671003237 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 748671003238 domain I; other site 748671003239 DNA binding groove [nucleotide binding] 748671003240 phosphate binding site [ion binding]; other site 748671003241 domain II; other site 748671003242 domain III; other site 748671003243 nucleotide binding site [chemical binding]; other site 748671003244 catalytic site [active] 748671003245 domain IV; other site 748671003246 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 748671003247 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 748671003248 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 748671003249 Glucose inhibited division protein A; Region: GIDA; pfam01134 748671003250 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 748671003251 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 748671003252 DNA binding site [nucleotide binding] 748671003253 active site 748671003254 Int/Topo IB signature motif; other site 748671003255 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 748671003256 active site 748671003257 HslU subunit interaction site [polypeptide binding]; other site 748671003258 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 748671003259 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748671003260 Walker A motif; other site 748671003261 ATP binding site [chemical binding]; other site 748671003262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 748671003263 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 748671003264 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 748671003265 active site 748671003266 catalytic residues [active] 748671003267 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 748671003268 catalytic tetrad [active] 748671003269 Aldo/keto reductases, related to diketogulonate reductase [General function prediction only]; Region: ARA1; COG0656 748671003270 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 748671003271 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 748671003272 camphor resistance protein CrcB; Provisional; Region: PRK14220 748671003273 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 748671003274 S-methylmethionine transporter; Provisional; Region: PRK11387 748671003275 dipeptidase PepV; Reviewed; Region: PRK07318 748671003276 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 748671003277 active site 748671003278 metal binding site [ion binding]; metal-binding site 748671003279 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 748671003280 Amino acid permease; Region: AA_permease_2; pfam13520 748671003281 putative ornithine decarboxylase; Region: lacto_ODC_hypo; TIGR04318 748671003282 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 748671003283 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 748671003284 catalytic residue [active] 748671003285 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 748671003286 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 748671003287 Aluminium resistance protein; Region: Alum_res; pfam06838 748671003288 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 748671003289 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748671003290 ATP binding site [chemical binding]; other site 748671003291 putative Mg++ binding site [ion binding]; other site 748671003292 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748671003293 nucleotide binding region [chemical binding]; other site 748671003294 ATP-binding site [chemical binding]; other site 748671003295 RQC domain; Region: RQC; pfam09382 748671003296 HRDC domain; Region: HRDC; pfam00570 748671003297 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 748671003298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748671003299 Walker A/P-loop; other site 748671003300 ATP binding site [chemical binding]; other site 748671003301 Q-loop/lid; other site 748671003302 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 748671003303 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748671003304 ABC transporter signature motif; other site 748671003305 Walker B; other site 748671003306 D-loop; other site 748671003307 H-loop/switch region; other site 748671003308 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748671003309 Walker A/P-loop; other site 748671003310 ATP binding site [chemical binding]; other site 748671003311 Q-loop/lid; other site 748671003312 ABC transporter signature motif; other site 748671003313 Walker B; other site 748671003314 D-loop; other site 748671003315 H-loop/switch region; other site 748671003316 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 748671003317 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 748671003318 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 748671003319 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 748671003320 active site 748671003321 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 748671003322 Coenzyme A binding pocket [chemical binding]; other site 748671003323 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 748671003324 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 748671003325 active site 748671003326 substrate binding site [chemical binding]; other site 748671003327 trimer interface [polypeptide binding]; other site 748671003328 CoA binding site [chemical binding]; other site 748671003329 Beta-lactamase; Region: Beta-lactamase; pfam00144 748671003330 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 748671003331 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 748671003332 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 748671003333 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 748671003334 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 748671003335 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 748671003336 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 748671003337 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 748671003338 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 748671003339 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748671003340 Coenzyme A binding pocket [chemical binding]; other site 748671003341 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 748671003342 peptidase T; Region: peptidase-T; TIGR01882 748671003343 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 748671003344 metal binding site [ion binding]; metal-binding site 748671003345 dimer interface [polypeptide binding]; other site 748671003346 recombination factor protein RarA; Provisional; Region: PRK14700 748671003347 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 748671003348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748671003349 Walker A motif; other site 748671003350 ATP binding site [chemical binding]; other site 748671003351 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 748671003352 putative catalytic residues [active] 748671003353 thiol/disulfide switch; other site 748671003354 ArsC family; Region: ArsC; pfam03960 748671003355 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 748671003356 active site 748671003357 catalytic site [active] 748671003358 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 748671003359 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 748671003360 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 748671003361 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 748671003362 active site 748671003363 metal binding site [ion binding]; metal-binding site 748671003364 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 748671003365 Bacterial surface layer protein; Region: SLAP; pfam03217 748671003366 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 748671003367 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748671003368 ATP binding site [chemical binding]; other site 748671003369 putative Mg++ binding site [ion binding]; other site 748671003370 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748671003371 nucleotide binding region [chemical binding]; other site 748671003372 ATP-binding site [chemical binding]; other site 748671003373 AAA domain; Region: AAA_21; pfam13304 748671003374 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 748671003375 HsdM N-terminal domain; Region: HsdM_N; pfam12161 748671003376 Methyltransferase domain; Region: Methyltransf_26; pfam13659 748671003377 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 748671003378 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 748671003379 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 748671003380 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 748671003381 TIR domain; Region: TIR_2; cl17458 748671003382 Uncharacterized conserved protein [Function unknown]; Region: COG1479 748671003383 Protein of unknown function DUF262; Region: DUF262; pfam03235 748671003384 Uncharacterized conserved protein [Function unknown]; Region: COG3472 748671003385 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 748671003386 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 748671003387 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 748671003388 Sel1-like repeats; Region: SEL1; smart00671 748671003389 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 748671003390 AAA domain; Region: AAA_33; pfam13671 748671003391 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748671003392 Walker A/P-loop; other site 748671003393 ATP binding site [chemical binding]; other site 748671003394 Q-loop/lid; other site 748671003395 Walker B; other site 748671003396 D-loop; other site 748671003397 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 748671003398 Sel1-like repeats; Region: SEL1; smart00671 748671003399 Sel1-like repeats; Region: SEL1; smart00671 748671003400 MucBP domain; Region: MucBP; pfam06458 748671003401 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 748671003402 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 748671003403 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 748671003404 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 748671003405 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 748671003406 Potassium binding sites [ion binding]; other site 748671003407 Cesium cation binding sites [ion binding]; other site 748671003408 lipoprotein signal peptidase; Provisional; Region: PRK14787 748671003409 lipoprotein signal peptidase; Provisional; Region: PRK14797 748671003410 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 748671003411 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 748671003412 RNA binding surface [nucleotide binding]; other site 748671003413 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 748671003414 active site 748671003415 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 748671003416 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 748671003417 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 748671003418 conserved cys residue [active] 748671003419 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 748671003420 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 748671003421 ATP-grasp domain; Region: ATP-grasp_4; cl17255 748671003422 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 748671003423 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 748671003424 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 748671003425 IMP binding site; other site 748671003426 dimer interface [polypeptide binding]; other site 748671003427 interdomain contacts; other site 748671003428 partial ornithine binding site; other site 748671003429 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 748671003430 Domain of unknown function (DUF814); Region: DUF814; pfam05670 748671003431 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 748671003432 EDD domain protein, DegV family; Region: DegV; TIGR00762 748671003433 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 748671003434 MutS domain III; Region: MutS_III; pfam05192 748671003435 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 748671003436 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748671003437 Walker A/P-loop; other site 748671003438 ATP binding site [chemical binding]; other site 748671003439 Q-loop/lid; other site 748671003440 ABC transporter signature motif; other site 748671003441 Walker B; other site 748671003442 D-loop; other site 748671003443 H-loop/switch region; other site 748671003444 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 748671003445 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 748671003446 active site 748671003447 DNA binding site [nucleotide binding] 748671003448 Int/Topo IB signature motif; other site 748671003449 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 748671003450 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 748671003451 active site 748671003452 Bacterial surface layer protein; Region: SLAP; pfam03217 748671003453 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 748671003454 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 748671003455 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748671003456 non-specific DNA binding site [nucleotide binding]; other site 748671003457 salt bridge; other site 748671003458 sequence-specific DNA binding site [nucleotide binding]; other site 748671003459 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 748671003460 active site 748671003461 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 748671003462 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 748671003463 DHHA2 domain; Region: DHHA2; pfam02833 748671003464 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748671003465 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748671003466 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 748671003467 dimerization interface [polypeptide binding]; other site 748671003468 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 748671003469 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 748671003470 CAP-like domain; other site 748671003471 active site 748671003472 primary dimer interface [polypeptide binding]; other site 748671003473 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 748671003474 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 748671003475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748671003476 Mg2+ binding site [ion binding]; other site 748671003477 G-X-G motif; other site 748671003478 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 748671003479 anchoring element; other site 748671003480 dimer interface [polypeptide binding]; other site 748671003481 ATP binding site [chemical binding]; other site 748671003482 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 748671003483 active site 748671003484 putative metal-binding site [ion binding]; other site 748671003485 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 748671003486 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 748671003487 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 748671003488 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 748671003489 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748671003490 ATP binding site [chemical binding]; other site 748671003491 putative Mg++ binding site [ion binding]; other site 748671003492 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748671003493 nucleotide binding region [chemical binding]; other site 748671003494 ATP-binding site [chemical binding]; other site 748671003495 Transposase, Mutator family; Region: Transposase_mut; pfam00872 748671003496 MULE transposase domain; Region: MULE; pfam10551 748671003497 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 748671003498 Isochorismatase family; Region: Isochorismatase; pfam00857 748671003499 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 748671003500 catalytic triad [active] 748671003501 conserved cis-peptide bond; other site 748671003502 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 748671003503 active site 748671003504 dimerization interface [polypeptide binding]; other site 748671003505 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 748671003506 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 748671003507 active site 748671003508 metal binding site [ion binding]; metal-binding site 748671003509 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 748671003510 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 748671003511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 748671003512 DivIVA protein; Region: DivIVA; pfam05103 748671003513 DivIVA domain; Region: DivI1A_domain; TIGR03544 748671003514 hypothetical protein; Provisional; Region: PRK13660 748671003515 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 748671003516 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 748671003517 Transglycosylase; Region: Transgly; pfam00912 748671003518 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 748671003519 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 748671003520 endonuclease III; Region: ENDO3c; smart00478 748671003521 minor groove reading motif; other site 748671003522 helix-hairpin-helix signature motif; other site 748671003523 substrate binding pocket [chemical binding]; other site 748671003524 active site 748671003525 Helix-turn-helix domain; Region: HTH_36; pfam13730 748671003526 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 748671003527 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 748671003528 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 748671003529 putative dimer interface [polypeptide binding]; other site 748671003530 putative anticodon binding site; other site 748671003531 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 748671003532 homodimer interface [polypeptide binding]; other site 748671003533 motif 1; other site 748671003534 motif 2; other site 748671003535 active site 748671003536 motif 3; other site 748671003537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 748671003538 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 748671003539 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 748671003540 active site 748671003541 catalytic site [active] 748671003542 substrate binding site [chemical binding]; other site 748671003543 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748671003544 ATP binding site [chemical binding]; other site 748671003545 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 748671003546 putative Mg++ binding site [ion binding]; other site 748671003547 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 748671003548 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 748671003549 Part of AAA domain; Region: AAA_19; pfam13245 748671003550 Family description; Region: UvrD_C_2; pfam13538 748671003551 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 748671003552 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 748671003553 mevalonate kinase; Region: mevalon_kin; TIGR00549 748671003554 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 748671003555 mevalonate kinase; Region: mevalon_kin; TIGR00549 748671003556 diphosphomevalonate decarboxylase; Region: PLN02407 748671003557 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 748671003558 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 748671003559 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 748671003560 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 748671003561 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 748671003562 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 748671003563 homotetramer interface [polypeptide binding]; other site 748671003564 FMN binding site [chemical binding]; other site 748671003565 homodimer contacts [polypeptide binding]; other site 748671003566 putative active site [active] 748671003567 putative substrate binding site [chemical binding]; other site 748671003568 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 748671003569 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 748671003570 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748671003571 active site 748671003572 motif I; other site 748671003573 motif II; other site 748671003574 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 748671003575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748671003576 S-adenosylmethionine binding site [chemical binding]; other site 748671003577 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 748671003578 conjugal transfer coupling protein TraG; Provisional; Region: PRK13822 748671003579 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 748671003580 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 748671003581 Catalytic site [active] 748671003582 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 748671003583 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 748671003584 Walker A/P-loop; other site 748671003585 ATP binding site [chemical binding]; other site 748671003586 Q-loop/lid; other site 748671003587 ABC transporter signature motif; other site 748671003588 Walker B; other site 748671003589 D-loop; other site 748671003590 H-loop/switch region; other site 748671003591 Predicted transcriptional regulators [Transcription]; Region: COG1725 748671003592 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748671003593 DNA-binding site [nucleotide binding]; DNA binding site 748671003594 peptidase T; Region: peptidase-T; TIGR01882 748671003595 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 748671003596 metal binding site [ion binding]; metal-binding site 748671003597 dimer interface [polypeptide binding]; other site 748671003598 Uncharacterized conserved protein [Function unknown]; Region: COG0327 748671003599 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 748671003600 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 748671003601 Family of unknown function (DUF633); Region: DUF633; pfam04816 748671003602 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 748671003603 putative active site [active] 748671003604 nucleotide binding site [chemical binding]; other site 748671003605 nudix motif; other site 748671003606 putative metal binding site [ion binding]; other site 748671003607 Peptidase family M23; Region: Peptidase_M23; pfam01551 748671003608 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 748671003609 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 748671003610 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 748671003611 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 748671003612 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 748671003613 DNA binding residues [nucleotide binding] 748671003614 DNA primase; Validated; Region: dnaG; PRK05667 748671003615 CHC2 zinc finger; Region: zf-CHC2; cl17510 748671003616 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 748671003617 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 748671003618 active site 748671003619 metal binding site [ion binding]; metal-binding site 748671003620 interdomain interaction site; other site 748671003621 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 748671003622 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 748671003623 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 748671003624 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 748671003625 motif 1; other site 748671003626 dimer interface [polypeptide binding]; other site 748671003627 active site 748671003628 motif 2; other site 748671003629 motif 3; other site 748671003630 Recombination protein O N terminal; Region: RecO_N; pfam11967 748671003631 DNA repair protein RecO; Region: reco; TIGR00613 748671003632 Recombination protein O C terminal; Region: RecO_C; pfam02565 748671003633 GTPase Era; Reviewed; Region: era; PRK00089 748671003634 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 748671003635 G1 box; other site 748671003636 GTP/Mg2+ binding site [chemical binding]; other site 748671003637 Switch I region; other site 748671003638 G2 box; other site 748671003639 Switch II region; other site 748671003640 G3 box; other site 748671003641 G4 box; other site 748671003642 G5 box; other site 748671003643 metal-binding heat shock protein; Provisional; Region: PRK00016 748671003644 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 748671003645 PhoH-like protein; Region: PhoH; pfam02562 748671003646 Yqey-like protein; Region: YqeY; pfam09424 748671003647 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 748671003648 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 748671003649 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 748671003650 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 748671003651 active site 748671003652 catalytic site [active] 748671003653 substrate binding site [chemical binding]; other site 748671003654 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 748671003655 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 748671003656 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 748671003657 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 748671003658 CT1975-like protein; Region: Cas_CT1975; pfam09344 748671003659 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 748671003660 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 748671003661 helicase Cas3; Provisional; Region: PRK09694 748671003662 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 748671003663 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 748671003664 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 748671003665 Transposase; Region: DDE_Tnp_ISL3; pfam01610 748671003666 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 748671003667 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 748671003668 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 748671003669 ligand binding site [chemical binding]; other site 748671003670 flexible hinge region; other site 748671003671 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 748671003672 non-specific DNA interactions [nucleotide binding]; other site 748671003673 DNA binding site [nucleotide binding] 748671003674 sequence specific DNA binding site [nucleotide binding]; other site 748671003675 putative cAMP binding site [chemical binding]; other site 748671003676 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 748671003677 dinuclear metal binding motif [ion binding]; other site 748671003678 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 748671003679 metal-binding site [ion binding] 748671003680 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 748671003681 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 748671003682 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 748671003683 Peptidase family M23; Region: Peptidase_M23; pfam01551 748671003684 methionine sulfoxide reductase A; Provisional; Region: PRK14054 748671003685 Uncharacterized conserved protein [Function unknown]; Region: COG1284 748671003686 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 748671003687 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 748671003688 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 748671003689 homoserine kinase; Provisional; Region: PRK01212 748671003690 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 748671003691 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 748671003692 homoserine dehydrogenase; Provisional; Region: PRK06349 748671003693 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 748671003694 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 748671003695 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 748671003696 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 748671003697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748671003698 catalytic residue [active] 748671003699 aspartate kinase; Reviewed; Region: PRK09034 748671003700 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 748671003701 putative catalytic residues [active] 748671003702 putative nucleotide binding site [chemical binding]; other site 748671003703 putative aspartate binding site [chemical binding]; other site 748671003704 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 748671003705 allosteric regulatory residue; other site 748671003706 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 748671003707 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 748671003708 catalytic core [active] 748671003709 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 748671003710 PLD-like domain; Region: PLDc_2; pfam13091 748671003711 homodimer interface [polypeptide binding]; other site 748671003712 putative active site [active] 748671003713 catalytic site [active] 748671003714 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 748671003715 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 748671003716 Walker A/P-loop; other site 748671003717 ATP binding site [chemical binding]; other site 748671003718 Q-loop/lid; other site 748671003719 ABC transporter signature motif; other site 748671003720 Walker B; other site 748671003721 D-loop; other site 748671003722 H-loop/switch region; other site 748671003723 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748671003724 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 748671003725 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748671003726 Walker A/P-loop; other site 748671003727 ATP binding site [chemical binding]; other site 748671003728 Q-loop/lid; other site 748671003729 ABC transporter signature motif; other site 748671003730 Walker B; other site 748671003731 D-loop; other site 748671003732 H-loop/switch region; other site 748671003733 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 748671003734 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 748671003735 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 748671003736 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748671003737 dimerization interface [polypeptide binding]; other site 748671003738 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 748671003739 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748671003740 Coenzyme A binding pocket [chemical binding]; other site 748671003741 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 748671003742 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 748671003743 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 748671003744 nucleotide binding site [chemical binding]; other site 748671003745 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 748671003746 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 748671003747 arginine deiminase; Provisional; Region: PRK01388 748671003748 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748671003749 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 748671003750 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748671003751 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748671003752 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 748671003753 dimerization interface [polypeptide binding]; other site 748671003754 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 748671003755 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 748671003756 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 748671003757 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748671003758 motif II; other site 748671003759 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 748671003760 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 748671003761 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 748671003762 Uncharacterized conserved protein [Function unknown]; Region: COG3589 748671003763 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 748671003764 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 748671003765 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 748671003766 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 748671003767 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748671003768 active site 748671003769 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 748671003770 DHH family; Region: DHH; pfam01368 748671003771 DHHA1 domain; Region: DHHA1; pfam02272 748671003772 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 748671003773 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 748671003774 active site 748671003775 catalytic site [active] 748671003776 GTP-binding protein LepA; Provisional; Region: PRK05433 748671003777 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 748671003778 G1 box; other site 748671003779 putative GEF interaction site [polypeptide binding]; other site 748671003780 GTP/Mg2+ binding site [chemical binding]; other site 748671003781 Switch I region; other site 748671003782 G2 box; other site 748671003783 G3 box; other site 748671003784 Switch II region; other site 748671003785 G4 box; other site 748671003786 G5 box; other site 748671003787 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 748671003788 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 748671003789 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 748671003790 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 748671003791 active site 748671003792 Ap4A binding cleft/pocket [chemical binding]; other site 748671003793 P4 phosphate binding site; other site 748671003794 nudix motif; other site 748671003795 putative P2/P3 phosphate binding site [ion binding]; other site 748671003796 chaperone protein DnaJ; Provisional; Region: PRK14276 748671003797 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 748671003798 HSP70 interaction site [polypeptide binding]; other site 748671003799 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 748671003800 substrate binding site [polypeptide binding]; other site 748671003801 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 748671003802 Zn binding sites [ion binding]; other site 748671003803 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 748671003804 dimer interface [polypeptide binding]; other site 748671003805 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 748671003806 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 748671003807 nucleotide binding site [chemical binding]; other site 748671003808 NEF interaction site [polypeptide binding]; other site 748671003809 SBD interface [polypeptide binding]; other site 748671003810 GrpE; Region: GrpE; pfam01025 748671003811 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 748671003812 dimer interface [polypeptide binding]; other site 748671003813 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 748671003814 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 748671003815 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 748671003816 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 748671003817 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 748671003818 active site 748671003819 Riboflavin kinase; Region: Flavokinase; smart00904 748671003820 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 748671003821 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 748671003822 RNA binding site [nucleotide binding]; other site 748671003823 active site 748671003824 ribosome-binding factor A; Provisional; Region: PRK13818 748671003825 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 748671003826 translation initiation factor IF-2; Validated; Region: infB; PRK05306 748671003827 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 748671003828 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 748671003829 G1 box; other site 748671003830 putative GEF interaction site [polypeptide binding]; other site 748671003831 GTP/Mg2+ binding site [chemical binding]; other site 748671003832 Switch I region; other site 748671003833 G2 box; other site 748671003834 G3 box; other site 748671003835 Switch II region; other site 748671003836 G4 box; other site 748671003837 G5 box; other site 748671003838 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 748671003839 Translation-initiation factor 2; Region: IF-2; pfam11987 748671003840 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 748671003841 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 748671003842 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 748671003843 putative RNA binding cleft [nucleotide binding]; other site 748671003844 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 748671003845 NusA N-terminal domain; Region: NusA_N; pfam08529 748671003846 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 748671003847 RNA binding site [nucleotide binding]; other site 748671003848 homodimer interface [polypeptide binding]; other site 748671003849 NusA-like KH domain; Region: KH_5; pfam13184 748671003850 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 748671003851 G-X-X-G motif; other site 748671003852 ribosome maturation protein RimP; Reviewed; Region: PRK00092 748671003853 Sm and related proteins; Region: Sm_like; cl00259 748671003854 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 748671003855 putative oligomer interface [polypeptide binding]; other site 748671003856 putative RNA binding site [nucleotide binding]; other site 748671003857 DNA polymerase III PolC; Validated; Region: polC; PRK00448 748671003858 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 748671003859 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 748671003860 generic binding surface II; other site 748671003861 generic binding surface I; other site 748671003862 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 748671003863 active site 748671003864 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 748671003865 active site 748671003866 catalytic site [active] 748671003867 substrate binding site [chemical binding]; other site 748671003868 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 748671003869 prolyl-tRNA synthetase; Provisional; Region: PRK09194 748671003870 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 748671003871 dimer interface [polypeptide binding]; other site 748671003872 motif 1; other site 748671003873 active site 748671003874 motif 2; other site 748671003875 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 748671003876 putative deacylase active site [active] 748671003877 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 748671003878 active site 748671003879 motif 3; other site 748671003880 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 748671003881 anticodon binding site; other site 748671003882 RIP metalloprotease RseP; Region: TIGR00054 748671003883 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 748671003884 active site 748671003885 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 748671003886 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 748671003887 protein binding site [polypeptide binding]; other site 748671003888 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 748671003889 putative substrate binding region [chemical binding]; other site 748671003890 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 748671003891 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 748671003892 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 748671003893 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 748671003894 catalytic residue [active] 748671003895 putative FPP diphosphate binding site; other site 748671003896 putative FPP binding hydrophobic cleft; other site 748671003897 dimer interface [polypeptide binding]; other site 748671003898 putative IPP diphosphate binding site; other site 748671003899 ribosome recycling factor; Reviewed; Region: frr; PRK00083 748671003900 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 748671003901 hinge region; other site 748671003902 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 748671003903 putative nucleotide binding site [chemical binding]; other site 748671003904 uridine monophosphate binding site [chemical binding]; other site 748671003905 homohexameric interface [polypeptide binding]; other site 748671003906 elongation factor Ts; Provisional; Region: tsf; PRK09377 748671003907 UBA/TS-N domain; Region: UBA; pfam00627 748671003908 Elongation factor TS; Region: EF_TS; pfam00889 748671003909 Elongation factor TS; Region: EF_TS; pfam00889 748671003910 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 748671003911 rRNA interaction site [nucleotide binding]; other site 748671003912 S8 interaction site; other site 748671003913 putative laminin-1 binding site; other site 748671003914 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 748671003915 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748671003916 S-adenosylmethionine binding site [chemical binding]; other site 748671003917 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 748671003918 GIY-YIG motif/motif A; other site 748671003919 putative active site [active] 748671003920 putative metal binding site [ion binding]; other site 748671003921 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 748671003922 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 748671003923 putative acyl-acceptor binding pocket; other site 748671003924 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 748671003925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748671003926 S-adenosylmethionine binding site [chemical binding]; other site 748671003927 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 748671003928 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 748671003929 active site 748671003930 Zn binding site [ion binding]; other site 748671003931 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748671003932 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748671003933 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 748671003934 Walker A/P-loop; other site 748671003935 ATP binding site [chemical binding]; other site 748671003936 Q-loop/lid; other site 748671003937 ABC transporter signature motif; other site 748671003938 Walker B; other site 748671003939 D-loop; other site 748671003940 H-loop/switch region; other site 748671003941 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 748671003942 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748671003943 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748671003944 Walker A/P-loop; other site 748671003945 ATP binding site [chemical binding]; other site 748671003946 Q-loop/lid; other site 748671003947 ABC transporter signature motif; other site 748671003948 Walker B; other site 748671003949 D-loop; other site 748671003950 H-loop/switch region; other site 748671003951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 748671003952 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 748671003953 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748671003954 LexA repressor; Validated; Region: PRK00215 748671003955 putative DNA binding site [nucleotide binding]; other site 748671003956 putative Zn2+ binding site [ion binding]; other site 748671003957 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 748671003958 Catalytic site [active] 748671003959 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 748671003960 active site 748671003961 catalytic triad [active] 748671003962 oxyanion hole [active] 748671003963 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 748671003964 active site 748671003965 Fe-S cluster binding site [ion binding]; other site 748671003966 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 748671003967 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 748671003968 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 748671003969 RimM N-terminal domain; Region: RimM; pfam01782 748671003970 PRC-barrel domain; Region: PRC; pfam05239 748671003971 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 748671003972 signal recognition particle protein; Provisional; Region: PRK10867 748671003973 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 748671003974 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 748671003975 P loop; other site 748671003976 GTP binding site [chemical binding]; other site 748671003977 Signal peptide binding domain; Region: SRP_SPB; pfam02978 748671003978 putative DNA-binding protein; Validated; Region: PRK00118 748671003979 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 748671003980 amino acid transporter; Region: 2A0306; TIGR00909 748671003981 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 748671003982 FtsX-like permease family; Region: FtsX; pfam02687 748671003983 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 748671003984 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 748671003985 Walker A/P-loop; other site 748671003986 ATP binding site [chemical binding]; other site 748671003987 Q-loop/lid; other site 748671003988 ABC transporter signature motif; other site 748671003989 Walker B; other site 748671003990 D-loop; other site 748671003991 H-loop/switch region; other site 748671003992 Peptidase family C69; Region: Peptidase_C69; pfam03577 748671003993 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 748671003994 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 748671003995 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 748671003996 P loop; other site 748671003997 GTP binding site [chemical binding]; other site 748671003998 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 748671003999 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 748671004000 Walker A/P-loop; other site 748671004001 ATP binding site [chemical binding]; other site 748671004002 Q-loop/lid; other site 748671004003 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 748671004004 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 748671004005 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 748671004006 ABC transporter signature motif; other site 748671004007 Walker B; other site 748671004008 D-loop; other site 748671004009 H-loop/switch region; other site 748671004010 ribonuclease III; Reviewed; Region: rnc; PRK00102 748671004011 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 748671004012 dimerization interface [polypeptide binding]; other site 748671004013 active site 748671004014 metal binding site [ion binding]; metal-binding site 748671004015 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 748671004016 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 748671004017 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 748671004018 peptide binding site [polypeptide binding]; other site 748671004019 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 748671004020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748671004021 dimer interface [polypeptide binding]; other site 748671004022 conserved gate region; other site 748671004023 putative PBP binding loops; other site 748671004024 ABC-ATPase subunit interface; other site 748671004025 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 748671004026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748671004027 dimer interface [polypeptide binding]; other site 748671004028 conserved gate region; other site 748671004029 putative PBP binding loops; other site 748671004030 ABC-ATPase subunit interface; other site 748671004031 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 748671004032 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 748671004033 Walker A/P-loop; other site 748671004034 ATP binding site [chemical binding]; other site 748671004035 Q-loop/lid; other site 748671004036 ABC transporter signature motif; other site 748671004037 Walker B; other site 748671004038 D-loop; other site 748671004039 H-loop/switch region; other site 748671004040 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 748671004041 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 748671004042 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 748671004043 Walker A/P-loop; other site 748671004044 ATP binding site [chemical binding]; other site 748671004045 Q-loop/lid; other site 748671004046 ABC transporter signature motif; other site 748671004047 Walker B; other site 748671004048 D-loop; other site 748671004049 H-loop/switch region; other site 748671004050 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 748671004051 acyl carrier protein; Provisional; Region: acpP; PRK00982 748671004052 putative phosphate acyltransferase; Provisional; Region: PRK05331 748671004053 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 748671004054 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 748671004055 ssDNA binding site; other site 748671004056 generic binding surface II; other site 748671004057 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748671004058 ATP binding site [chemical binding]; other site 748671004059 putative Mg++ binding site [ion binding]; other site 748671004060 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748671004061 nucleotide binding region [chemical binding]; other site 748671004062 ATP-binding site [chemical binding]; other site 748671004063 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 748671004064 DAK2 domain; Region: Dak2; pfam02734 748671004065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 748671004066 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 748671004067 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 748671004068 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 748671004069 Transposase; Region: DDE_Tnp_ISL3; pfam01610 748671004070 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 748671004071 Thiamine pyrophosphokinase; Region: TPK; cd07995 748671004072 active site 748671004073 dimerization interface [polypeptide binding]; other site 748671004074 thiamine binding site [chemical binding]; other site 748671004075 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 748671004076 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 748671004077 substrate binding site [chemical binding]; other site 748671004078 hexamer interface [polypeptide binding]; other site 748671004079 metal binding site [ion binding]; metal-binding site 748671004080 GTPase RsgA; Reviewed; Region: PRK00098 748671004081 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 748671004082 RNA binding site [nucleotide binding]; other site 748671004083 homodimer interface [polypeptide binding]; other site 748671004084 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 748671004085 GTPase/Zn-binding domain interface [polypeptide binding]; other site 748671004086 GTP/Mg2+ binding site [chemical binding]; other site 748671004087 G4 box; other site 748671004088 G5 box; other site 748671004089 G1 box; other site 748671004090 Switch I region; other site 748671004091 G2 box; other site 748671004092 G3 box; other site 748671004093 Switch II region; other site 748671004094 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 748671004095 Catalytic domain of Protein Kinases; Region: PKc; cd00180 748671004096 active site 748671004097 ATP binding site [chemical binding]; other site 748671004098 substrate binding site [chemical binding]; other site 748671004099 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 748671004100 substrate binding site [chemical binding]; other site 748671004101 activation loop (A-loop); other site 748671004102 activation loop (A-loop); other site 748671004103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 748671004104 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 748671004105 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 748671004106 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 748671004107 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 748671004108 Protein phosphatase 2C; Region: PP2C; pfam00481 748671004109 active site 748671004110 16S rRNA methyltransferase B; Provisional; Region: PRK14902 748671004111 NusB family; Region: NusB; pfam01029 748671004112 putative RNA binding site [nucleotide binding]; other site 748671004113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748671004114 S-adenosylmethionine binding site [chemical binding]; other site 748671004115 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 748671004116 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 748671004117 putative active site [active] 748671004118 substrate binding site [chemical binding]; other site 748671004119 putative cosubstrate binding site; other site 748671004120 catalytic site [active] 748671004121 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 748671004122 substrate binding site [chemical binding]; other site 748671004123 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 748671004124 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 748671004125 ATP binding site [chemical binding]; other site 748671004126 putative Mg++ binding site [ion binding]; other site 748671004127 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 748671004128 nucleotide binding region [chemical binding]; other site 748671004129 ATP-binding site [chemical binding]; other site 748671004130 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 748671004131 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 748671004132 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 748671004133 catalytic site [active] 748671004134 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 748671004135 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 748671004136 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 748671004137 Walker A/P-loop; other site 748671004138 ATP binding site [chemical binding]; other site 748671004139 Q-loop/lid; other site 748671004140 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 748671004141 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 748671004142 ABC transporter signature motif; other site 748671004143 Walker B; other site 748671004144 D-loop; other site 748671004145 H-loop/switch region; other site 748671004146 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 748671004147 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 748671004148 RNA binding surface [nucleotide binding]; other site 748671004149 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 748671004150 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 748671004151 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 748671004152 substrate binding pocket [chemical binding]; other site 748671004153 chain length determination region; other site 748671004154 substrate-Mg2+ binding site; other site 748671004155 catalytic residues [active] 748671004156 aspartate-rich region 1; other site 748671004157 active site lid residues [active] 748671004158 aspartate-rich region 2; other site 748671004159 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 748671004160 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 748671004161 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 748671004162 generic binding surface II; other site 748671004163 generic binding surface I; other site 748671004164 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 748671004165 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 748671004166 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 748671004167 homodimer interface [polypeptide binding]; other site 748671004168 NADP binding site [chemical binding]; other site 748671004169 substrate binding site [chemical binding]; other site 748671004170 transcription antitermination factor NusB; Region: nusB; TIGR01951 748671004171 putative RNA binding site [nucleotide binding]; other site 748671004172 Asp23 family; Region: Asp23; pfam03780 748671004173 elongation factor P; Validated; Region: PRK00529 748671004174 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 748671004175 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 748671004176 RNA binding site [nucleotide binding]; other site 748671004177 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 748671004178 RNA binding site [nucleotide binding]; other site 748671004179 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 748671004180 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 748671004181 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 748671004182 active site 748671004183 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 748671004184 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 748671004185 Uncharacterized conserved protein [Function unknown]; Region: COG1284 748671004186 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 748671004187 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 748671004188 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 748671004189 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 748671004190 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 748671004191 active site 1 [active] 748671004192 dimer interface [polypeptide binding]; other site 748671004193 hexamer interface [polypeptide binding]; other site 748671004194 active site 2 [active] 748671004195 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 748671004196 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 748671004197 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 748671004198 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 748671004199 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 748671004200 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 748671004201 active site 748671004202 Bacterial surface layer protein; Region: SLAP; pfam03217 748671004203 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 748671004204 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 748671004205 substrate binding pocket [chemical binding]; other site 748671004206 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 748671004207 ArsC family; Region: ArsC; pfam03960 748671004208 putative ArsC-like catalytic residues; other site 748671004209 putative TRX-like catalytic residues [active] 748671004210 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748671004211 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748671004212 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748671004213 Walker A/P-loop; other site 748671004214 ATP binding site [chemical binding]; other site 748671004215 Q-loop/lid; other site 748671004216 ABC transporter signature motif; other site 748671004217 Walker B; other site 748671004218 D-loop; other site 748671004219 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 748671004220 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 748671004221 Walker A/P-loop; other site 748671004222 ATP binding site [chemical binding]; other site 748671004223 Q-loop/lid; other site 748671004224 ABC transporter signature motif; other site 748671004225 Walker B; other site 748671004226 D-loop; other site 748671004227 H-loop/switch region; other site 748671004228 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 748671004229 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 748671004230 active site 748671004231 motif I; other site 748671004232 motif II; other site 748671004233 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 748671004234 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 748671004235 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696 748671004236 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696 748671004237 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 748671004238 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 748671004239 methionine sulfoxide reductase B; Provisional; Region: PRK00222 748671004240 SelR domain; Region: SelR; pfam01641 748671004241 Sugar transport protein; Region: Sugar_transport; pfam06800 748671004242 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 748671004243 L-lactate permease; Region: Lactate_perm; cl00701 748671004244 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 748671004245 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 748671004246 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 748671004247 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 748671004248 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 748671004249 ATP-grasp domain; Region: ATP-grasp_4; cl17255 748671004250 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 748671004251 IMP binding site; other site 748671004252 dimer interface [polypeptide binding]; other site 748671004253 partial ornithine binding site; other site 748671004254 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 748671004255 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 748671004256 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 748671004257 catalytic site [active] 748671004258 subunit interface [polypeptide binding]; other site 748671004259 dihydroorotase; Validated; Region: pyrC; PRK09357 748671004260 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 748671004261 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 748671004262 active site 748671004263 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 748671004264 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 748671004265 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 748671004266 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 748671004267 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748671004268 active site 748671004269 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 748671004270 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 748671004271 heterodimer interface [polypeptide binding]; other site 748671004272 active site 748671004273 FMN binding site [chemical binding]; other site 748671004274 homodimer interface [polypeptide binding]; other site 748671004275 substrate binding site [chemical binding]; other site 748671004276 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 748671004277 active site 748671004278 dimer interface [polypeptide binding]; other site 748671004279 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748671004280 active site 748671004281 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 748671004282 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 748671004283 dimer interface [polypeptide binding]; other site 748671004284 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 748671004285 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 748671004286 ABC transporter; Region: ABC_tran_2; pfam12848 748671004287 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 748671004288 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 748671004289 Viral Desmoplakin N-terminus; Region: Desmo_N; pfam06771 748671004290 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 748671004291 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 748671004292 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 748671004293 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 748671004294 dimer interface [polypeptide binding]; other site 748671004295 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 748671004296 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 748671004297 Probable transposase; Region: OrfB_IS605; pfam01385 748671004298 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 748671004299 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 748671004300 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 748671004301 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 748671004302 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 748671004303 DNA binding residues [nucleotide binding] 748671004304 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 748671004305 catalytic nucleophile [active] 748671004306 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 748671004307 teramer interface [polypeptide binding]; other site 748671004308 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 748671004309 active site 748671004310 FMN binding site [chemical binding]; other site 748671004311 catalytic residues [active] 748671004312 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 748671004313 propionate/acetate kinase; Provisional; Region: PRK12379 748671004314 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 748671004315 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 748671004316 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 748671004317 inner membrane transporter YjeM; Provisional; Region: PRK15238 748671004318 Fic family protein [Function unknown]; Region: COG3177 748671004319 Fic/DOC family; Region: Fic; pfam02661 748671004320 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 748671004321 Protein of unknown function (DUF805); Region: DUF805; pfam05656 748671004322 OsmC-like protein; Region: OsmC; pfam02566 748671004323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748671004324 putative substrate translocation pore; other site 748671004325 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748671004326 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 748671004327 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748671004328 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748671004329 dimer interface [polypeptide binding]; other site 748671004330 phosphorylation site [posttranslational modification] 748671004331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748671004332 ATP binding site [chemical binding]; other site 748671004333 Mg2+ binding site [ion binding]; other site 748671004334 G-X-G motif; other site 748671004335 Response regulator receiver domain; Region: Response_reg; pfam00072 748671004336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748671004337 active site 748671004338 phosphorylation site [posttranslational modification] 748671004339 intermolecular recognition site; other site 748671004340 dimerization interface [polypeptide binding]; other site 748671004341 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 748671004342 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 748671004343 synthetase active site [active] 748671004344 NTP binding site [chemical binding]; other site 748671004345 metal binding site [ion binding]; metal-binding site 748671004346 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 748671004347 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 748671004348 active site 748671004349 homodimer interface [polypeptide binding]; other site 748671004350 catalytic site [active] 748671004351 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 748671004352 Melibiase; Region: Melibiase; pfam02065 748671004353 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 748671004354 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 748671004355 Walker A/P-loop; other site 748671004356 ATP binding site [chemical binding]; other site 748671004357 Q-loop/lid; other site 748671004358 ABC transporter signature motif; other site 748671004359 Walker B; other site 748671004360 D-loop; other site 748671004361 H-loop/switch region; other site 748671004362 TOBE domain; Region: TOBE; pfam03459 748671004363 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 748671004364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748671004365 dimer interface [polypeptide binding]; other site 748671004366 conserved gate region; other site 748671004367 putative PBP binding loops; other site 748671004368 ABC-ATPase subunit interface; other site 748671004369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748671004370 dimer interface [polypeptide binding]; other site 748671004371 conserved gate region; other site 748671004372 putative PBP binding loops; other site 748671004373 ABC-ATPase subunit interface; other site 748671004374 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 748671004375 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 748671004376 Transcriptional regulators [Transcription]; Region: PurR; COG1609 748671004377 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 748671004378 DNA binding site [nucleotide binding] 748671004379 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 748671004380 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 748671004381 active site 748671004382 catalytic residues [active] 748671004383 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 748671004384 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 748671004385 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 748671004386 galactokinase; Provisional; Region: PRK05322 748671004387 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 748671004388 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 748671004389 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 748671004390 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 748671004391 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 748671004392 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 748671004393 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 748671004394 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 748671004395 HPr interaction site; other site 748671004396 glycerol kinase (GK) interaction site [polypeptide binding]; other site 748671004397 active site 748671004398 phosphorylation site [posttranslational modification] 748671004399 Transcriptional regulators [Transcription]; Region: PurR; COG1609 748671004400 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 748671004401 DNA binding site [nucleotide binding] 748671004402 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 748671004403 putative dimerization interface [polypeptide binding]; other site 748671004404 putative ligand binding site [chemical binding]; other site 748671004405 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 748671004406 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 748671004407 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 748671004408 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 748671004409 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 748671004410 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 748671004411 NAD binding site [chemical binding]; other site 748671004412 homodimer interface [polypeptide binding]; other site 748671004413 active site 748671004414 substrate binding site [chemical binding]; other site 748671004415 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 748671004416 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 748671004417 Transcriptional regulators [Transcription]; Region: PurR; COG1609 748671004418 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 748671004419 DNA binding site [nucleotide binding] 748671004420 domain linker motif; other site 748671004421 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 748671004422 TIGR02687 family protein; Region: TIGR02687 748671004423 PglZ domain; Region: PglZ; pfam08665 748671004424 Transposase; Region: DEDD_Tnp_IS110; pfam01548 748671004425 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 748671004426 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 748671004427 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 748671004428 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 748671004429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 748671004430 homodimer interface [polypeptide binding]; other site 748671004431 catalytic residue [active] 748671004432 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 748671004433 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 748671004434 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 748671004435 active site 748671004436 RDD family; Region: RDD; pfam06271 748671004437 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 748671004438 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 748671004439 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 748671004440 active site 748671004441 P-loop; other site 748671004442 phosphorylation site [posttranslational modification] 748671004443 methionine cluster; other site 748671004444 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 748671004445 active site 748671004446 phosphorylation site [posttranslational modification] 748671004447 metal binding site [ion binding]; metal-binding site 748671004448 exoaminopeptidase; Provisional; Region: PRK09961 748671004449 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 748671004450 oligomer interface [polypeptide binding]; other site 748671004451 active site 748671004452 metal binding site [ion binding]; metal-binding site 748671004453 HTH domain; Region: HTH_11; pfam08279 748671004454 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 748671004455 PRD domain; Region: PRD; pfam00874 748671004456 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 748671004457 active site 748671004458 P-loop; other site 748671004459 phosphorylation site [posttranslational modification] 748671004460 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 748671004461 active site 748671004462 phosphorylation site [posttranslational modification] 748671004463 hypothetical protein; Provisional; Region: PRK06194 748671004464 classical (c) SDRs; Region: SDR_c; cd05233 748671004465 NAD(P) binding site [chemical binding]; other site 748671004466 active site 748671004467 hypothetical protein; Provisional; Region: PRK06194 748671004468 classical (c) SDRs; Region: SDR_c; cd05233 748671004469 NAD(P) binding site [chemical binding]; other site 748671004470 active site 748671004471 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 748671004472 dimer interface [polypeptide binding]; other site 748671004473 FMN binding site [chemical binding]; other site 748671004474 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 748671004475 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 748671004476 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 748671004477 active pocket/dimerization site; other site 748671004478 active site 748671004479 phosphorylation site [posttranslational modification] 748671004480 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 748671004481 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 748671004482 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 748671004483 active site 748671004484 phosphorylation site [posttranslational modification] 748671004485 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 748671004486 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 748671004487 DNA-binding site [nucleotide binding]; DNA binding site 748671004488 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 748671004489 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 748671004490 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 748671004491 putative active site [active] 748671004492 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 748671004493 dimer interface [polypeptide binding]; other site 748671004494 active site 748671004495 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 748671004496 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 748671004497 Integrase core domain; Region: rve; pfam00665 748671004498 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 748671004499 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 748671004500 Transcriptional regulators [Transcription]; Region: PurR; COG1609 748671004501 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 748671004502 DNA binding site [nucleotide binding] 748671004503 domain linker motif; other site 748671004504 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 748671004505 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 748671004506 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 748671004507 putative active site [active] 748671004508 putative catalytic site [active] 748671004509 DNA polymerase IV; Reviewed; Region: PRK03103 748671004510 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 748671004511 active site 748671004512 DNA binding site [nucleotide binding] 748671004513 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 748671004514 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 748671004515 Transposase; Region: DDE_Tnp_ISL3; pfam01610 748671004516 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 748671004517 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 748671004518 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 748671004519 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 748671004520 Aluminium resistance protein; Region: Alum_res; pfam06838 748671004521 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 748671004522 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 748671004523 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 748671004524 active site residue [active] 748671004525 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 748671004526 Rhomboid family; Region: Rhomboid; pfam01694 748671004527 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 748671004528 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 748671004529 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 748671004530 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 748671004531 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 748671004532 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 748671004533 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 748671004534 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 748671004535 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 748671004536 nucleotide binding site [chemical binding]; other site 748671004537 RelB antitoxin; Region: RelB; cl01171 748671004538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 748671004539 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 748671004540 IHF - DNA interface [nucleotide binding]; other site 748671004541 IHF dimer interface [polypeptide binding]; other site 748671004542 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 748671004543 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 748671004544 Walker A/P-loop; other site 748671004545 ATP binding site [chemical binding]; other site 748671004546 Q-loop/lid; other site 748671004547 ABC transporter signature motif; other site 748671004548 Walker B; other site 748671004549 D-loop; other site 748671004550 H-loop/switch region; other site 748671004551 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 748671004552 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 748671004553 ABC-ATPase subunit interface; other site 748671004554 dimer interface [polypeptide binding]; other site 748671004555 putative PBP binding regions; other site 748671004556 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 748671004557 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 748671004558 intersubunit interface [polypeptide binding]; other site 748671004559 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 748671004560 heme-binding site [chemical binding]; other site 748671004561 Bacterial surface layer protein; Region: SLAP; pfam03217 748671004562 TIGR02452 family protein; Region: TIGR02452 748671004563 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 748671004564 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 748671004565 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 748671004566 amidohydrolase; Region: amidohydrolases; TIGR01891 748671004567 metal binding site [ion binding]; metal-binding site 748671004568 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 748671004569 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 748671004570 active site 748671004571 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 748671004572 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 748671004573 peptide binding site [polypeptide binding]; other site 748671004574 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748671004575 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 748671004576 active site 748671004577 motif I; other site 748671004578 motif II; other site 748671004579 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 748671004580 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 748671004581 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 748671004582 Multicopper oxidase; Region: Cu-oxidase; pfam00394 748671004583 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 748671004584 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 748671004585 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 748671004586 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 748671004587 NAD(P) binding site [chemical binding]; other site 748671004588 LDH/MDH dimer interface [polypeptide binding]; other site 748671004589 substrate binding site [chemical binding]; other site 748671004590 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 748671004591 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 748671004592 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 748671004593 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 748671004594 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 748671004595 putative tRNA-binding site [nucleotide binding]; other site 748671004596 B3/4 domain; Region: B3_4; pfam03483 748671004597 tRNA synthetase B5 domain; Region: B5; smart00874 748671004598 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 748671004599 dimer interface [polypeptide binding]; other site 748671004600 motif 1; other site 748671004601 motif 3; other site 748671004602 motif 2; other site 748671004603 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 748671004604 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 748671004605 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 748671004606 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 748671004607 dimer interface [polypeptide binding]; other site 748671004608 motif 1; other site 748671004609 active site 748671004610 motif 2; other site 748671004611 motif 3; other site 748671004612 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 748671004613 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 748671004614 substrate binding pocket [chemical binding]; other site 748671004615 membrane-bound complex binding site; other site 748671004616 hinge residues; other site 748671004617 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 748671004618 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 748671004619 Walker A/P-loop; other site 748671004620 ATP binding site [chemical binding]; other site 748671004621 Q-loop/lid; other site 748671004622 ABC transporter signature motif; other site 748671004623 Walker B; other site 748671004624 D-loop; other site 748671004625 H-loop/switch region; other site 748671004626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748671004627 dimer interface [polypeptide binding]; other site 748671004628 conserved gate region; other site 748671004629 putative PBP binding loops; other site 748671004630 ABC-ATPase subunit interface; other site 748671004631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748671004632 dimer interface [polypeptide binding]; other site 748671004633 conserved gate region; other site 748671004634 putative PBP binding loops; other site 748671004635 ABC-ATPase subunit interface; other site 748671004636 Predicted transcriptional regulators [Transcription]; Region: COG1733 748671004637 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 748671004638 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 748671004639 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 748671004640 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 748671004641 Acylphosphatase; Region: Acylphosphatase; pfam00708 748671004642 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 748671004643 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 748671004644 putative deacylase active site [active] 748671004645 CAAX protease self-immunity; Region: Abi; cl00558 748671004646 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 748671004647 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 748671004648 dimerization interface [polypeptide binding]; other site 748671004649 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748671004650 dimer interface [polypeptide binding]; other site 748671004651 phosphorylation site [posttranslational modification] 748671004652 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748671004653 ATP binding site [chemical binding]; other site 748671004654 Mg2+ binding site [ion binding]; other site 748671004655 G-X-G motif; other site 748671004656 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748671004657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748671004658 active site 748671004659 phosphorylation site [posttranslational modification] 748671004660 intermolecular recognition site; other site 748671004661 dimerization interface [polypeptide binding]; other site 748671004662 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748671004663 DNA binding site [nucleotide binding] 748671004664 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 748671004665 hypothetical protein; Provisional; Region: PRK13670 748671004666 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 748671004667 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 748671004668 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748671004669 Zn2+ binding site [ion binding]; other site 748671004670 Mg2+ binding site [ion binding]; other site 748671004671 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 748671004672 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 748671004673 active site 748671004674 (T/H)XGH motif; other site 748671004675 GTPase YqeH; Provisional; Region: PRK13796 748671004676 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 748671004677 GTP/Mg2+ binding site [chemical binding]; other site 748671004678 G4 box; other site 748671004679 G5 box; other site 748671004680 G1 box; other site 748671004681 Switch I region; other site 748671004682 G2 box; other site 748671004683 G3 box; other site 748671004684 Switch II region; other site 748671004685 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase 748671004686 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748671004687 active site 748671004688 motif I; other site 748671004689 motif II; other site 748671004690 adenosine deaminase; Provisional; Region: PRK09358 748671004691 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 748671004692 active site 748671004693 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 748671004694 Melibiase; Region: Melibiase; pfam02065 748671004695 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 748671004696 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 748671004697 active site turn [active] 748671004698 phosphorylation site [posttranslational modification] 748671004699 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 748671004700 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 748671004701 HPr interaction site; other site 748671004702 glycerol kinase (GK) interaction site [polypeptide binding]; other site 748671004703 active site 748671004704 phosphorylation site [posttranslational modification] 748671004705 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 748671004706 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 748671004707 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 748671004708 substrate binding [chemical binding]; other site 748671004709 active site 748671004710 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 748671004711 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 748671004712 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 748671004713 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 748671004714 23S rRNA binding site [nucleotide binding]; other site 748671004715 L21 binding site [polypeptide binding]; other site 748671004716 L13 binding site [polypeptide binding]; other site 748671004717 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 748671004718 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 748671004719 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 748671004720 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 748671004721 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748671004722 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 748671004723 Coenzyme A binding pocket [chemical binding]; other site 748671004724 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 748671004725 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 748671004726 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 748671004727 Walker A/P-loop; other site 748671004728 ATP binding site [chemical binding]; other site 748671004729 Q-loop/lid; other site 748671004730 ABC transporter signature motif; other site 748671004731 Walker B; other site 748671004732 D-loop; other site 748671004733 H-loop/switch region; other site 748671004734 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 748671004735 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 748671004736 LytTr DNA-binding domain; Region: LytTR; smart00850 748671004737 Abi-like protein; Region: Abi_2; pfam07751 748671004738 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 748671004739 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 748671004740 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 748671004741 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 748671004742 active site 748671004743 dimer interface [polypeptide binding]; other site 748671004744 motif 1; other site 748671004745 motif 2; other site 748671004746 motif 3; other site 748671004747 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 748671004748 anticodon binding site; other site 748671004749 primosomal protein DnaI; Reviewed; Region: PRK08939 748671004750 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 748671004751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748671004752 Walker A motif; other site 748671004753 ATP binding site [chemical binding]; other site 748671004754 Walker B motif; other site 748671004755 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 748671004756 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 748671004757 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 748671004758 ATP cone domain; Region: ATP-cone; pfam03477 748671004759 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 748671004760 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 748671004761 CoA-binding site [chemical binding]; other site 748671004762 ATP-binding [chemical binding]; other site 748671004763 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 748671004764 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 748671004765 DNA binding site [nucleotide binding] 748671004766 catalytic residue [active] 748671004767 H2TH interface [polypeptide binding]; other site 748671004768 putative catalytic residues [active] 748671004769 turnover-facilitating residue; other site 748671004770 intercalation triad [nucleotide binding]; other site 748671004771 8OG recognition residue [nucleotide binding]; other site 748671004772 putative reading head residues; other site 748671004773 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 748671004774 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 748671004775 DNA polymerase I; Provisional; Region: PRK05755 748671004776 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 748671004777 active site 748671004778 metal binding site 1 [ion binding]; metal-binding site 748671004779 putative 5' ssDNA interaction site; other site 748671004780 metal binding site 3; metal-binding site 748671004781 metal binding site 2 [ion binding]; metal-binding site 748671004782 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 748671004783 putative DNA binding site [nucleotide binding]; other site 748671004784 putative metal binding site [ion binding]; other site 748671004785 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 748671004786 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 748671004787 active site 748671004788 DNA binding site [nucleotide binding] 748671004789 catalytic site [active] 748671004790 HflC protein; Region: hflC; TIGR01932 748671004791 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 748671004792 RelB antitoxin; Region: RelB; cl01171 748671004793 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 748671004794 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 748671004795 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 748671004796 Zn binding site [ion binding]; other site 748671004797 amino-acid N-acetyltransferase; Region: PLN02825 748671004798 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 748671004799 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 748671004800 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 748671004801 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 748671004802 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 748671004803 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 748671004804 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 748671004805 putative tRNA-binding site [nucleotide binding]; other site 748671004806 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 748671004807 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 748671004808 catalytic residues [active] 748671004809 Protein of unknown function (DUF805); Region: DUF805; pfam05656 748671004810 Protein of unknown function (DUF805); Region: DUF805; cl01224 748671004811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748671004812 S-adenosylmethionine binding site [chemical binding]; other site 748671004813 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 748671004814 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 748671004815 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 748671004816 Walker A/P-loop; other site 748671004817 ATP binding site [chemical binding]; other site 748671004818 Q-loop/lid; other site 748671004819 ABC transporter signature motif; other site 748671004820 Walker B; other site 748671004821 D-loop; other site 748671004822 H-loop/switch region; other site 748671004823 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 748671004824 HIT family signature motif; other site 748671004825 catalytic residue [active] 748671004826 YtxH-like protein; Region: YtxH; cl02079 748671004827 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 748671004828 SurA N-terminal domain; Region: SurA_N_3; cl07813 748671004829 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 748671004830 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 748671004831 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 748671004832 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 748671004833 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 748671004834 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 748671004835 intersubunit interface [polypeptide binding]; other site 748671004836 catalytic residue [active] 748671004837 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 748671004838 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 748671004839 generic binding surface I; other site 748671004840 generic binding surface II; other site 748671004841 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 748671004842 Zn2+ binding site [ion binding]; other site 748671004843 Mg2+ binding site [ion binding]; other site 748671004844 P-loop containing region of AAA domain; Region: AAA_29; cl17516 748671004845 AAA domain; Region: AAA_23; pfam13476 748671004846 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 748671004847 active site 748671004848 metal binding site [ion binding]; metal-binding site 748671004849 DNA binding site [nucleotide binding] 748671004850 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 748671004851 hypothetical protein; Provisional; Region: PRK13676 748671004852 Transglycosylase; Region: Transgly; pfam00912 748671004853 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 748671004854 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 748671004855 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 748671004856 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 748671004857 active site 748671004858 phosphoenolpyruvate synthase; Validated; Region: PRK06464 748671004859 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 748671004860 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 748671004861 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 748671004862 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 748671004863 catalytic core [active] 748671004864 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 748671004865 amphipathic channel; other site 748671004866 Asn-Pro-Ala signature motifs; other site 748671004867 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 748671004868 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 748671004869 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 748671004870 beta-galactosidase; Region: BGL; TIGR03356 748671004871 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 748671004872 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 748671004873 Lipase (class 2); Region: Lipase_2; pfam01674 748671004874 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 748671004875 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293; cl07913 748671004876 malonate decarboxylase, beta subunit; Region: malonate_beta; TIGR03133 748671004877 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 748671004878 malonate decarboxylase acyl carrier protein; Region: malonate_delta; TIGR03130 748671004879 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 748671004880 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 748671004881 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 748671004882 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748671004883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748671004884 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 748671004885 dimerization interface [polypeptide binding]; other site 748671004886 Acyltransferase family; Region: Acyl_transf_3; pfam01757 748671004887 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 748671004888 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 748671004889 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 748671004890 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 748671004891 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 748671004892 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 748671004893 putative active site [active] 748671004894 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 748671004895 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 748671004896 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 748671004897 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 748671004898 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 748671004899 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 748671004900 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 748671004901 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 748671004902 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 748671004903 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748671004904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748671004905 putative substrate translocation pore; other site 748671004906 Transcriptional regulators [Transcription]; Region: PurR; COG1609 748671004907 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 748671004908 DNA binding site [nucleotide binding] 748671004909 domain linker motif; other site 748671004910 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 748671004911 dimerization interface [polypeptide binding]; other site 748671004912 ligand binding site [chemical binding]; other site 748671004913 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 748671004914 tetramer (dimer of dimers) interface [polypeptide binding]; other site 748671004915 active site 748671004916 dimer interface [polypeptide binding]; other site 748671004917 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 748671004918 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 748671004919 substrate binding site [chemical binding]; other site 748671004920 hexamer interface [polypeptide binding]; other site 748671004921 metal binding site [ion binding]; metal-binding site 748671004922 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 748671004923 putative active site [active] 748671004924 YdjC motif; other site 748671004925 Mg binding site [ion binding]; other site 748671004926 putative homodimer interface [polypeptide binding]; other site 748671004927 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 748671004928 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 748671004929 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 748671004930 active site turn [active] 748671004931 phosphorylation site [posttranslational modification] 748671004932 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 748671004933 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 748671004934 active site turn [active] 748671004935 phosphorylation site [posttranslational modification] 748671004936 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 748671004937 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 748671004938 HPr interaction site; other site 748671004939 glycerol kinase (GK) interaction site [polypeptide binding]; other site 748671004940 active site 748671004941 phosphorylation site [posttranslational modification] 748671004942 CAT RNA binding domain; Region: CAT_RBD; smart01061 748671004943 transcriptional antiterminator BglG; Provisional; Region: PRK09772 748671004944 PRD domain; Region: PRD; pfam00874 748671004945 PRD domain; Region: PRD; pfam00874 748671004946 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 748671004947 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 748671004948 hexamer (dimer of trimers) interface [polypeptide binding]; other site 748671004949 trimer interface [polypeptide binding]; other site 748671004950 substrate binding site [chemical binding]; other site 748671004951 Mn binding site [ion binding]; other site 748671004952 Transcriptional regulators [Transcription]; Region: PurR; COG1609 748671004953 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 748671004954 DNA binding site [nucleotide binding] 748671004955 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 748671004956 ligand binding site [chemical binding]; other site 748671004957 dimerization interface [polypeptide binding]; other site 748671004958 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 748671004959 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 748671004960 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 748671004961 EDD domain protein, DegV family; Region: DegV; TIGR00762 748671004962 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 748671004963 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 748671004964 Helix-turn-helix domain; Region: HTH_38; pfam13936 748671004965 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 748671004966 DNA-binding interface [nucleotide binding]; DNA binding site 748671004967 Integrase core domain; Region: rve; pfam00665 748671004968 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 748671004969 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 748671004970 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 748671004971 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 748671004972 Cupin domain; Region: Cupin_2; cl17218 748671004973 Helix-turn-helix domain; Region: HTH_18; pfam12833 748671004974 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 748671004975 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 748671004976 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 748671004977 nucleotide binding site [chemical binding]; other site 748671004978 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 748671004979 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748671004980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748671004981 putative substrate translocation pore; other site 748671004982 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 748671004983 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 748671004984 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 748671004985 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 748671004986 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 748671004987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 748671004988 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 748671004989 Enterocin A Immunity; Region: EntA_Immun; pfam08951 748671004990 Response regulator receiver domain; Region: Response_reg; pfam00072 748671004991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748671004992 active site 748671004993 phosphorylation site [posttranslational modification] 748671004994 intermolecular recognition site; other site 748671004995 dimerization interface [polypeptide binding]; other site 748671004996 LytTr DNA-binding domain; Region: LytTR; cl04498 748671004997 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 748671004998 Enterocin A Immunity; Region: EntA_Immun; pfam08951 748671004999 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 748671005000 UbiA prenyltransferase family; Region: UbiA; pfam01040 748671005001 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 748671005002 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 748671005003 nudix motif; other site 748671005004 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 748671005005 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 748671005006 intersubunit interface [polypeptide binding]; other site 748671005007 active site 748671005008 zinc binding site [ion binding]; other site 748671005009 Na+ binding site [ion binding]; other site 748671005010 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 748671005011 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 748671005012 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 748671005013 active site 748671005014 HIGH motif; other site 748671005015 KMSK motif region; other site 748671005016 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 748671005017 tRNA binding surface [nucleotide binding]; other site 748671005018 anticodon binding site; other site 748671005019 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 748671005020 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 748671005021 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 748671005022 putative substrate binding site [chemical binding]; other site 748671005023 putative ATP binding site [chemical binding]; other site 748671005024 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 748671005025 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 748671005026 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 748671005027 PspC domain; Region: PspC; pfam04024 748671005028 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 748671005029 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 748671005030 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 748671005031 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 748671005032 HIGH motif; other site 748671005033 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 748671005034 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 748671005035 active site 748671005036 KMSKS motif; other site 748671005037 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 748671005038 tRNA binding surface [nucleotide binding]; other site 748671005039 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 748671005040 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 748671005041 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 748671005042 active site 748671005043 Transcriptional regulator [Transcription]; Region: LysR; COG0583 748671005044 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 748671005045 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 748671005046 dimerization interface [polypeptide binding]; other site 748671005047 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 748671005048 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 748671005049 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 748671005050 UbiA prenyltransferase family; Region: UbiA; pfam01040 748671005051 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 748671005052 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 748671005053 substrate binding pocket [chemical binding]; other site 748671005054 chain length determination region; other site 748671005055 substrate-Mg2+ binding site; other site 748671005056 catalytic residues [active] 748671005057 aspartate-rich region 1; other site 748671005058 active site lid residues [active] 748671005059 aspartate-rich region 2; other site 748671005060 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 748671005061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748671005062 S-adenosylmethionine binding site [chemical binding]; other site 748671005063 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 748671005064 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 748671005065 Walker A/P-loop; other site 748671005066 ATP binding site [chemical binding]; other site 748671005067 Q-loop/lid; other site 748671005068 ABC transporter signature motif; other site 748671005069 Walker B; other site 748671005070 D-loop; other site 748671005071 H-loop/switch region; other site 748671005072 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 748671005073 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 748671005074 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748671005075 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748671005076 Walker A/P-loop; other site 748671005077 ATP binding site [chemical binding]; other site 748671005078 Q-loop/lid; other site 748671005079 ABC transporter signature motif; other site 748671005080 Walker B; other site 748671005081 D-loop; other site 748671005082 H-loop/switch region; other site 748671005083 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 748671005084 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 748671005085 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 748671005086 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 748671005087 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 748671005088 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 748671005089 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 748671005090 putative active site [active] 748671005091 Uncharacterized conserved protein [Function unknown]; Region: COG3589 748671005092 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 748671005093 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 748671005094 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 748671005095 putative active site [active] 748671005096 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 748671005097 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 748671005098 active site turn [active] 748671005099 phosphorylation site [posttranslational modification] 748671005100 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 748671005101 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 748671005102 HPr interaction site; other site 748671005103 glycerol kinase (GK) interaction site [polypeptide binding]; other site 748671005104 active site 748671005105 phosphorylation site [posttranslational modification] 748671005106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748671005107 Major Facilitator Superfamily; Region: MFS_1; pfam07690 748671005108 putative substrate translocation pore; other site 748671005109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748671005110 S-adenosylmethionine synthetase; Validated; Region: PRK05250 748671005111 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 748671005112 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 748671005113 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 748671005114 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 748671005115 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 748671005116 intersubunit interface [polypeptide binding]; other site 748671005117 Domain of unknown function (DUF4323); Region: DUF4323; pfam14211 748671005118 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 748671005119 seryl-tRNA synthetase; Provisional; Region: PRK05431 748671005120 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 748671005121 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 748671005122 dimer interface [polypeptide binding]; other site 748671005123 active site 748671005124 motif 1; other site 748671005125 motif 2; other site 748671005126 motif 3; other site 748671005127 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 748671005128 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 748671005129 Uncharacterized conserved protein [Function unknown]; Region: COG0398 748671005130 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 748671005131 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 748671005132 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 748671005133 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748671005134 non-specific DNA binding site [nucleotide binding]; other site 748671005135 salt bridge; other site 748671005136 sequence-specific DNA binding site [nucleotide binding]; other site 748671005137 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 748671005138 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 748671005139 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 748671005140 NAD(P) binding site [chemical binding]; other site 748671005141 catalytic residues [active] 748671005142 Transposase; Region: DEDD_Tnp_IS110; pfam01548 748671005143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 748671005144 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 748671005145 Double zinc ribbon; Region: DZR; pfam12773 748671005146 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 748671005147 MMPL family; Region: MMPL; pfam03176 748671005148 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 748671005149 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 748671005150 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 748671005151 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 748671005152 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748671005153 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 748671005154 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 748671005155 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 748671005156 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 748671005157 Cl binding site [ion binding]; other site 748671005158 oligomer interface [polypeptide binding]; other site 748671005159 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 748671005160 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 748671005161 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 748671005162 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 748671005163 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 748671005164 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 748671005165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748671005166 dimer interface [polypeptide binding]; other site 748671005167 conserved gate region; other site 748671005168 ABC-ATPase subunit interface; other site 748671005169 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 748671005170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748671005171 dimer interface [polypeptide binding]; other site 748671005172 conserved gate region; other site 748671005173 putative PBP binding loops; other site 748671005174 ABC-ATPase subunit interface; other site 748671005175 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 748671005176 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 748671005177 Walker A/P-loop; other site 748671005178 ATP binding site [chemical binding]; other site 748671005179 Q-loop/lid; other site 748671005180 ABC transporter signature motif; other site 748671005181 Walker B; other site 748671005182 D-loop; other site 748671005183 H-loop/switch region; other site 748671005184 TOBE domain; Region: TOBE_2; pfam08402 748671005185 Peptidase family C69; Region: Peptidase_C69; pfam03577 748671005186 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 748671005187 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 748671005188 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 748671005189 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 748671005190 active site 748671005191 catalytic site [active] 748671005192 substrate binding site [chemical binding]; other site 748671005193 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 748671005194 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 748671005195 Predicted membrane protein [Function unknown]; Region: COG2323 748671005196 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 748671005197 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 748671005198 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 748671005199 beta-galactosidase; Region: BGL; TIGR03356 748671005200 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 748671005201 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 748671005202 active site turn [active] 748671005203 phosphorylation site [posttranslational modification] 748671005204 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 748671005205 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 748671005206 HPr interaction site; other site 748671005207 glycerol kinase (GK) interaction site [polypeptide binding]; other site 748671005208 active site 748671005209 phosphorylation site [posttranslational modification] 748671005210 transcriptional antiterminator BglG; Provisional; Region: PRK09772 748671005211 CAT RNA binding domain; Region: CAT_RBD; smart01061 748671005212 PRD domain; Region: PRD; pfam00874 748671005213 PRD domain; Region: PRD; pfam00874 748671005214 PAS domain; Region: PAS_10; pfam13596 748671005215 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748671005216 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748671005217 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 748671005218 Walker A/P-loop; other site 748671005219 ATP binding site [chemical binding]; other site 748671005220 Q-loop/lid; other site 748671005221 ABC transporter signature motif; other site 748671005222 Walker B; other site 748671005223 D-loop; other site 748671005224 H-loop/switch region; other site 748671005225 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 748671005226 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748671005227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748671005228 active site 748671005229 phosphorylation site [posttranslational modification] 748671005230 intermolecular recognition site; other site 748671005231 dimerization interface [polypeptide binding]; other site 748671005232 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748671005233 DNA binding site [nucleotide binding] 748671005234 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 748671005235 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748671005236 dimer interface [polypeptide binding]; other site 748671005237 phosphorylation site [posttranslational modification] 748671005238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748671005239 ATP binding site [chemical binding]; other site 748671005240 Mg2+ binding site [ion binding]; other site 748671005241 G-X-G motif; other site 748671005242 Predicted membrane protein [Function unknown]; Region: COG3212 748671005243 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 748671005244 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 748671005245 Predicted membrane protein [Function unknown]; Region: COG3212 748671005246 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 748671005247 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 748671005248 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 748671005249 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748671005250 Coenzyme A binding pocket [chemical binding]; other site 748671005251 Transcriptional regulators [Transcription]; Region: MarR; COG1846 748671005252 MarR family; Region: MarR; pfam01047 748671005253 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 748671005254 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 748671005255 peptide binding site [polypeptide binding]; other site 748671005256 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 748671005257 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 748671005258 elongation factor P; Validated; Region: PRK00529 748671005259 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 748671005260 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 748671005261 RNA binding site [nucleotide binding]; other site 748671005262 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 748671005263 RNA binding site [nucleotide binding]; other site 748671005264 pantothenate kinase; Provisional; Region: PRK05439 748671005265 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 748671005266 ATP-binding site [chemical binding]; other site 748671005267 CoA-binding site [chemical binding]; other site 748671005268 Mg2+-binding site [ion binding]; other site 748671005269 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 748671005270 active site 748671005271 catalytic triad [active] 748671005272 oxyanion hole [active] 748671005273 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 748671005274 Coenzyme A binding pocket [chemical binding]; other site 748671005275 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 748671005276 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 748671005277 substrate binding pocket [chemical binding]; other site 748671005278 membrane-bound complex binding site; other site 748671005279 hinge residues; other site 748671005280 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 748671005281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748671005282 Walker A/P-loop; other site 748671005283 ATP binding site [chemical binding]; other site 748671005284 Q-loop/lid; other site 748671005285 ABC transporter signature motif; other site 748671005286 Walker B; other site 748671005287 D-loop; other site 748671005288 H-loop/switch region; other site 748671005289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748671005290 dimer interface [polypeptide binding]; other site 748671005291 conserved gate region; other site 748671005292 putative PBP binding loops; other site 748671005293 ABC-ATPase subunit interface; other site 748671005294 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 748671005295 Part of AAA domain; Region: AAA_19; pfam13245 748671005296 Family description; Region: UvrD_C_2; pfam13538 748671005297 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 748671005298 active site 748671005299 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 748671005300 catalytic core [active] 748671005301 Predicted membrane protein [Function unknown]; Region: COG4640 748671005302 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 748671005303 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 748671005304 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 748671005305 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 748671005306 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 748671005307 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748671005308 motif II; other site 748671005309 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 748671005310 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 748671005311 active pocket/dimerization site; other site 748671005312 active site 748671005313 phosphorylation site [posttranslational modification] 748671005314 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 748671005315 active site 748671005316 homodimer interface [polypeptide binding]; other site 748671005317 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 748671005318 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 748671005319 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 748671005320 putative active site [active] 748671005321 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 748671005322 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 748671005323 NAD binding site [chemical binding]; other site 748671005324 sugar binding site [chemical binding]; other site 748671005325 divalent metal binding site [ion binding]; other site 748671005326 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 748671005327 dimer interface [polypeptide binding]; other site 748671005328 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 748671005329 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748671005330 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 748671005331 active site 748671005332 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 748671005333 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 748671005334 Coenzyme A binding pocket [chemical binding]; other site 748671005335 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 748671005336 Uncharacterized conserved protein [Function unknown]; Region: COG3589 748671005337 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 748671005338 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 748671005339 putative active site [active] 748671005340 putative metal binding site [ion binding]; other site 748671005341 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 748671005342 Bacterial surface layer protein; Region: SLAP; pfam03217 748671005343 Transposase [DNA replication, recombination, and repair]; Region: COG5421 748671005344 Transposase, Mutator family; Region: Transposase_mut; pfam00872 748671005345 MULE transposase domain; Region: MULE; pfam10551 748671005346 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748671005347 non-specific DNA binding site [nucleotide binding]; other site 748671005348 salt bridge; other site 748671005349 sequence-specific DNA binding site [nucleotide binding]; other site 748671005350 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 748671005351 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 748671005352 Transposase; Region: DEDD_Tnp_IS110; pfam01548 748671005353 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 748671005354 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 748671005355 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 748671005356 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 748671005357 NADP binding site [chemical binding]; other site 748671005358 active site 748671005359 putative substrate binding site [chemical binding]; other site 748671005360 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 748671005361 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 748671005362 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 748671005363 substrate binding site; other site 748671005364 tetramer interface; other site 748671005365 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 748671005366 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 748671005367 NAD binding site [chemical binding]; other site 748671005368 substrate binding site [chemical binding]; other site 748671005369 homodimer interface [polypeptide binding]; other site 748671005370 active site 748671005371 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 748671005372 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 748671005373 DNA binding residues [nucleotide binding] 748671005374 dimer interface [polypeptide binding]; other site 748671005375 Methyltransferase domain; Region: Methyltransf_31; pfam13847 748671005376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748671005377 S-adenosylmethionine binding site [chemical binding]; other site 748671005378 RelB antitoxin; Region: RelB; cl01171 748671005379 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 748671005380 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 748671005381 active site 748671005382 Abi-like protein; Region: Abi_2; cl01988 748671005383 Transposase, Mutator family; Region: Transposase_mut; pfam00872 748671005384 MULE transposase domain; Region: MULE; pfam10551 748671005385 Abi-like protein; Region: Abi_2; pfam07751 748671005386 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 748671005387 Transposase; Region: DEDD_Tnp_IS110; pfam01548 748671005388 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 748671005389 Transposase; Region: DEDD_Tnp_IS110; pfam01548 748671005390 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 748671005391 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 748671005392 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 748671005393 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 748671005394 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 748671005395 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 748671005396 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 748671005397 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 748671005398 UDP-galactopyranose mutase; Region: GLF; pfam03275 748671005399 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 748671005400 active site 748671005401 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 748671005402 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 748671005403 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 748671005404 active site 748671005405 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 748671005406 Bacterial sugar transferase; Region: Bac_transf; pfam02397 748671005407 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 748671005408 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 748671005409 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 748671005410 Chain length determinant protein; Region: Wzz; cl15801 748671005411 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 748671005412 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 748671005413 Helix-turn-helix domain; Region: HTH_38; pfam13936 748671005414 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 748671005415 DNA-binding interface [nucleotide binding]; DNA binding site 748671005416 Integrase core domain; Region: rve; pfam00665 748671005417 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 748671005418 RelB antitoxin; Region: RelB; cl01171 748671005419 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 748671005420 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 748671005421 HflX GTPase family; Region: HflX; cd01878 748671005422 G1 box; other site 748671005423 GTP/Mg2+ binding site [chemical binding]; other site 748671005424 Switch I region; other site 748671005425 G2 box; other site 748671005426 G3 box; other site 748671005427 Switch II region; other site 748671005428 G4 box; other site 748671005429 G5 box; other site 748671005430 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 748671005431 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 748671005432 NlpC/P60 family; Region: NLPC_P60; pfam00877 748671005433 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 748671005434 NlpC/P60 family; Region: NLPC_P60; pfam00877 748671005435 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 748671005436 NlpC/P60 family; Region: NLPC_P60; pfam00877 748671005437 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 748671005438 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 748671005439 catalytic site [active] 748671005440 G-X2-G-X-G-K; other site 748671005441 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 748671005442 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 748671005443 Probable transposase; Region: OrfB_IS605; pfam01385 748671005444 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 748671005445 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 748671005446 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 748671005447 dimer interface [polypeptide binding]; other site 748671005448 putative radical transfer pathway; other site 748671005449 diiron center [ion binding]; other site 748671005450 tyrosyl radical; other site 748671005451 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 748671005452 putative active site [active] 748671005453 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 748671005454 Uncharacterized conserved protein [Function unknown]; Region: COG2966 748671005455 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 748671005456 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 748671005457 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 748671005458 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748671005459 Walker A/P-loop; other site 748671005460 ATP binding site [chemical binding]; other site 748671005461 Q-loop/lid; other site 748671005462 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 748671005463 ABC transporter signature motif; other site 748671005464 Walker B; other site 748671005465 D-loop; other site 748671005466 ABC transporter; Region: ABC_tran_2; pfam12848 748671005467 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 748671005468 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 748671005469 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 748671005470 Protein of unknown function (DUF554); Region: DUF554; pfam04474 748671005471 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 748671005472 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 748671005473 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 748671005474 active site 748671005475 Zn binding site [ion binding]; other site 748671005476 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 748671005477 Fic/DOC family; Region: Fic; cl00960 748671005478 Enterocin A Immunity; Region: EntA_Immun; pfam08951 748671005479 CAAX protease self-immunity; Region: Abi; pfam02517 748671005480 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748671005481 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748671005482 non-specific DNA binding site [nucleotide binding]; other site 748671005483 salt bridge; other site 748671005484 sequence-specific DNA binding site [nucleotide binding]; other site 748671005485 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 748671005486 substrate binding site [chemical binding]; other site 748671005487 THF binding site; other site 748671005488 zinc-binding site [ion binding]; other site 748671005489 S-ribosylhomocysteinase; Provisional; Region: PRK02260 748671005490 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 748671005491 L-lactate permease; Region: Lactate_perm; cl00701 748671005492 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 748671005493 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 748671005494 dimer interface [polypeptide binding]; other site 748671005495 putative PBP binding regions; other site 748671005496 ABC-ATPase subunit interface; other site 748671005497 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 748671005498 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 748671005499 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 748671005500 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 748671005501 intersubunit interface [polypeptide binding]; other site 748671005502 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 748671005503 dimerization interface [polypeptide binding]; other site 748671005504 putative DNA binding site [nucleotide binding]; other site 748671005505 putative Zn2+ binding site [ion binding]; other site 748671005506 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 748671005507 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 748671005508 active site 748671005509 phosphorylation site [posttranslational modification] 748671005510 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 748671005511 active site 748671005512 P-loop; other site 748671005513 phosphorylation site [posttranslational modification] 748671005514 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 748671005515 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 748671005516 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 748671005517 putative substrate binding site [chemical binding]; other site 748671005518 putative ATP binding site [chemical binding]; other site 748671005519 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 748671005520 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 748671005521 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 748671005522 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 748671005523 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 748671005524 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 748671005525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748671005526 Walker A/P-loop; other site 748671005527 ATP binding site [chemical binding]; other site 748671005528 Q-loop/lid; other site 748671005529 ABC transporter signature motif; other site 748671005530 Walker B; other site 748671005531 D-loop; other site 748671005532 H-loop/switch region; other site 748671005533 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748671005534 salt bridge; other site 748671005535 non-specific DNA binding site [nucleotide binding]; other site 748671005536 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 748671005537 sequence-specific DNA binding site [nucleotide binding]; other site 748671005538 Helix-turn-helix domain; Region: HTH_38; pfam13936 748671005539 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 748671005540 DNA-binding interface [nucleotide binding]; DNA binding site 748671005541 Integrase core domain; Region: rve; pfam00665 748671005542 Response regulator receiver domain; Region: Response_reg; pfam00072 748671005543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748671005544 active site 748671005545 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 748671005546 phosphorylation site [posttranslational modification] 748671005547 intermolecular recognition site; other site 748671005548 dimerization interface [polypeptide binding]; other site 748671005549 LytTr DNA-binding domain; Region: LytTR; pfam04397 748671005550 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 748671005551 CAAX protease self-immunity; Region: Abi; pfam02517 748671005552 CAAX protease self-immunity; Region: Abi; pfam02517 748671005553 alpha-glucosidase; Provisional; Region: PRK10426 748671005554 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 748671005555 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 748671005556 trimer interface [polypeptide binding]; other site 748671005557 active site 748671005558 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 748671005559 catalytic site [active] 748671005560 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 748671005561 FAD binding domain; Region: FAD_binding_4; pfam01565 748671005562 Enterocin A Immunity; Region: EntA_Immun; pfam08951 748671005563 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 748671005564 aspartate racemase; Region: asp_race; TIGR00035 748671005565 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 748671005566 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 748671005567 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 748671005568 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 748671005569 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 748671005570 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 748671005571 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 748671005572 dimer interface [polypeptide binding]; other site 748671005573 phosphorylation site [posttranslational modification] 748671005574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 748671005575 ATP binding site [chemical binding]; other site 748671005576 Mg2+ binding site [ion binding]; other site 748671005577 G-X-G motif; other site 748671005578 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 748671005579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 748671005580 active site 748671005581 phosphorylation site [posttranslational modification] 748671005582 intermolecular recognition site; other site 748671005583 dimerization interface [polypeptide binding]; other site 748671005584 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 748671005585 DNA binding site [nucleotide binding] 748671005586 hypothetical protein; Validated; Region: PRK07121 748671005587 FMN-binding domain; Region: FMN_bind; pfam04205 748671005588 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 748671005589 HPr interaction site; other site 748671005590 glycerol kinase (GK) interaction site [polypeptide binding]; other site 748671005591 active site 748671005592 phosphorylation site [posttranslational modification] 748671005593 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 748671005594 beta-galactosidase; Region: BGL; TIGR03356 748671005595 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 748671005596 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 748671005597 active site turn [active] 748671005598 phosphorylation site [posttranslational modification] 748671005599 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 748671005600 transcriptional antiterminator BglG; Provisional; Region: PRK09772 748671005601 CAT RNA binding domain; Region: CAT_RBD; smart01061 748671005602 PRD domain; Region: PRD; pfam00874 748671005603 PRD domain; Region: PRD; pfam00874 748671005604 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748671005605 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748671005606 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 748671005607 Walker A/P-loop; other site 748671005608 ATP binding site [chemical binding]; other site 748671005609 Q-loop/lid; other site 748671005610 ABC transporter signature motif; other site 748671005611 Walker B; other site 748671005612 D-loop; other site 748671005613 H-loop/switch region; other site 748671005614 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748671005615 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748671005616 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748671005617 Walker A/P-loop; other site 748671005618 ATP binding site [chemical binding]; other site 748671005619 Q-loop/lid; other site 748671005620 ABC transporter signature motif; other site 748671005621 Walker B; other site 748671005622 D-loop; other site 748671005623 H-loop/switch region; other site 748671005624 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 748671005625 GTP-binding protein YchF; Reviewed; Region: PRK09601 748671005626 YchF GTPase; Region: YchF; cd01900 748671005627 G1 box; other site 748671005628 GTP/Mg2+ binding site [chemical binding]; other site 748671005629 Switch I region; other site 748671005630 G2 box; other site 748671005631 Switch II region; other site 748671005632 G3 box; other site 748671005633 G4 box; other site 748671005634 G5 box; other site 748671005635 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 748671005636 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 748671005637 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 748671005638 ParB-like nuclease domain; Region: ParB; smart00470 748671005639 Helix-turn-helix; Region: HTH_3; pfam01381 748671005640 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 748671005641 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 748671005642 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 748671005643 ParB-like nuclease domain; Region: ParB; smart00470 748671005644 KorB domain; Region: KorB; pfam08535 748671005645 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 748671005646 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 748671005647 S-adenosylmethionine binding site [chemical binding]; other site 748671005648 Colicin V production protein; Region: Colicin_V; pfam02674 748671005649 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 748671005650 ApbE family; Region: ApbE; pfam02424 748671005651 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 748671005652 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 748671005653 Predicted flavoprotein [General function prediction only]; Region: COG0431 748671005654 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 748671005655 Predicted flavoprotein [General function prediction only]; Region: COG0431 748671005656 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 748671005657 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748671005658 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 748671005659 WHG domain; Region: WHG; pfam13305 748671005660 Peptidase family C69; Region: Peptidase_C69; pfam03577 748671005661 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748671005662 Walker B; other site 748671005663 D-loop; other site 748671005664 H-loop/switch region; other site 748671005665 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 748671005666 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 748671005667 Probable transposase; Region: OrfB_IS605; pfam01385 748671005668 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 748671005669 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 748671005670 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 748671005671 DNA binding residues [nucleotide binding] 748671005672 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 748671005673 catalytic residues [active] 748671005674 catalytic nucleophile [active] 748671005675 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748671005676 Q-loop/lid; other site 748671005677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748671005678 Walker A/P-loop; other site 748671005679 ATP binding site [chemical binding]; other site 748671005680 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 748671005681 FtsX-like permease family; Region: FtsX; pfam02687 748671005682 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 748671005683 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 748671005684 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 748671005685 catalytic core [active] 748671005686 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 748671005687 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 748671005688 catalytic site [active] 748671005689 hypothetical protein; Validated; Region: PRK02101 748671005690 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 748671005691 nucleotide binding site/active site [active] 748671005692 HIT family signature motif; other site 748671005693 catalytic residue [active] 748671005694 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 748671005695 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 748671005696 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 748671005697 Probable transposase; Region: OrfB_IS605; pfam01385 748671005698 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 748671005699 Sec23/Sec24 zinc finger; Region: zf-Sec23_Sec24; pfam04810 748671005700 LytTr DNA-binding domain; Region: LytTR; pfam04397 748671005701 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 748671005702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748671005703 POT family; Region: PTR2; cl17359 748671005704 Peptidase family M1; Region: Peptidase_M1; pfam01433 748671005705 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 748671005706 Zn binding site [ion binding]; other site 748671005707 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 748671005708 drug efflux system protein MdtG; Provisional; Region: PRK09874 748671005709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748671005710 putative substrate translocation pore; other site 748671005711 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 748671005712 putative ADP-ribose binding site [chemical binding]; other site 748671005713 putative active site [active] 748671005714 Transposase, Mutator family; Region: Transposase_mut; pfam00872 748671005715 MULE transposase domain; Region: MULE; pfam10551 748671005716 Transposase, Mutator family; Region: Transposase_mut; pfam00872 748671005717 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748671005718 non-specific DNA binding site [nucleotide binding]; other site 748671005719 salt bridge; other site 748671005720 sequence-specific DNA binding site [nucleotide binding]; other site 748671005721 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 748671005722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748671005723 dimer interface [polypeptide binding]; other site 748671005724 conserved gate region; other site 748671005725 putative PBP binding loops; other site 748671005726 ABC-ATPase subunit interface; other site 748671005727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 748671005728 dimer interface [polypeptide binding]; other site 748671005729 conserved gate region; other site 748671005730 ABC-ATPase subunit interface; other site 748671005731 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 748671005732 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 748671005733 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 748671005734 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 748671005735 Walker A/P-loop; other site 748671005736 ATP binding site [chemical binding]; other site 748671005737 Q-loop/lid; other site 748671005738 ABC transporter signature motif; other site 748671005739 Walker B; other site 748671005740 D-loop; other site 748671005741 H-loop/switch region; other site 748671005742 TOBE domain; Region: TOBE_2; pfam08402 748671005743 beta-phosphoglucomutase; Region: bPGM; TIGR01990 748671005744 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748671005745 motif II; other site 748671005746 maltose phosphorylase; Provisional; Region: PRK13807 748671005747 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 748671005748 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 748671005749 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 748671005750 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 748671005751 homodimer interface [polypeptide binding]; other site 748671005752 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 748671005753 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 748671005754 active site 748671005755 homodimer interface [polypeptide binding]; other site 748671005756 catalytic site [active] 748671005757 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 748671005758 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 748671005759 Ca binding site [ion binding]; other site 748671005760 active site 748671005761 catalytic site [active] 748671005762 PAS domain; Region: PAS_10; pfam13596 748671005763 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 748671005764 propionate/acetate kinase; Provisional; Region: PRK12379 748671005765 Transcriptional regulators [Transcription]; Region: PurR; COG1609 748671005766 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 748671005767 DNA binding site [nucleotide binding] 748671005768 domain linker motif; other site 748671005769 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 748671005770 ligand binding site [chemical binding]; other site 748671005771 dimerization interface [polypeptide binding]; other site 748671005772 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 748671005773 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 748671005774 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748671005775 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 748671005776 Walker A/P-loop; other site 748671005777 ATP binding site [chemical binding]; other site 748671005778 ABC transporter; Region: ABC_tran; pfam00005 748671005779 Q-loop/lid; other site 748671005780 ABC transporter signature motif; other site 748671005781 Walker B; other site 748671005782 D-loop; other site 748671005783 H-loop/switch region; other site 748671005784 Transposase, Mutator family; Region: Transposase_mut; pfam00872 748671005785 MULE transposase domain; Region: MULE; pfam10551 748671005786 glycerol kinase; Provisional; Region: glpK; PRK00047 748671005787 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 748671005788 N- and C-terminal domain interface [polypeptide binding]; other site 748671005789 active site 748671005790 MgATP binding site [chemical binding]; other site 748671005791 catalytic site [active] 748671005792 metal binding site [ion binding]; metal-binding site 748671005793 glycerol binding site [chemical binding]; other site 748671005794 homotetramer interface [polypeptide binding]; other site 748671005795 homodimer interface [polypeptide binding]; other site 748671005796 FBP binding site [chemical binding]; other site 748671005797 protein IIAGlc interface [polypeptide binding]; other site 748671005798 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 748671005799 dimer interface [polypeptide binding]; other site 748671005800 substrate binding site [chemical binding]; other site 748671005801 ATP binding site [chemical binding]; other site 748671005802 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748671005803 non-specific DNA binding site [nucleotide binding]; other site 748671005804 salt bridge; other site 748671005805 sequence-specific DNA binding site [nucleotide binding]; other site 748671005806 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 748671005807 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 748671005808 RelB antitoxin; Region: RelB; cl01171 748671005809 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 748671005810 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 748671005811 catalytic triad [active] 748671005812 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 748671005813 NlpC/P60 family; Region: NLPC_P60; pfam00877 748671005814 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748671005815 non-specific DNA binding site [nucleotide binding]; other site 748671005816 salt bridge; other site 748671005817 sequence-specific DNA binding site [nucleotide binding]; other site 748671005818 EamA-like transporter family; Region: EamA; pfam00892 748671005819 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 748671005820 EamA-like transporter family; Region: EamA; pfam00892 748671005821 EamA-like transporter family; Region: EamA; pfam00892 748671005822 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 748671005823 EamA-like transporter family; Region: EamA; pfam00892 748671005824 EamA-like transporter family; Region: EamA; pfam00892 748671005825 Uncharacterized conserved protein [Function unknown]; Region: COG1434 748671005826 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 748671005827 putative active site [active] 748671005828 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 748671005829 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 748671005830 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 748671005831 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 748671005832 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 748671005833 adenylosuccinate lyase; Provisional; Region: PRK07492 748671005834 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 748671005835 tetramer interface [polypeptide binding]; other site 748671005836 active site 748671005837 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 748671005838 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 748671005839 GDP-binding site [chemical binding]; other site 748671005840 ACT binding site; other site 748671005841 IMP binding site; other site 748671005842 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 748671005843 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 748671005844 active site 748671005845 Uncharacterized conserved protein [Function unknown]; Region: COG3589 748671005846 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 748671005847 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 748671005848 dimer interface [polypeptide binding]; other site 748671005849 active site 748671005850 YcaO-like family; Region: YcaO; pfam02624 748671005851 YcaO-like family; Region: YcaO; pfam02624 748671005852 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 748671005853 putative FMN binding site [chemical binding]; other site 748671005854 NADPH bind site [chemical binding]; other site 748671005855 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 748671005856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748671005857 Walker A/P-loop; other site 748671005858 ATP binding site [chemical binding]; other site 748671005859 Q-loop/lid; other site 748671005860 ABC transporter signature motif; other site 748671005861 Walker B; other site 748671005862 D-loop; other site 748671005863 H-loop/switch region; other site 748671005864 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 748671005865 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 748671005866 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 748671005867 catalytic triad [active] 748671005868 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 748671005869 active site 748671005870 putative transport protein YifK; Provisional; Region: PRK10746 748671005871 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 748671005872 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 748671005873 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 748671005874 Catalytic site [active] 748671005875 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 748671005876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748671005877 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 748671005878 Walker A motif; other site 748671005879 ATP binding site [chemical binding]; other site 748671005880 Walker B motif; other site 748671005881 arginine finger; other site 748671005882 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 748671005883 Walker A motif; other site 748671005884 ATP binding site [chemical binding]; other site 748671005885 Walker B motif; other site 748671005886 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 748671005887 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 748671005888 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 748671005889 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 748671005890 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 748671005891 Walker A/P-loop; other site 748671005892 ATP binding site [chemical binding]; other site 748671005893 Q-loop/lid; other site 748671005894 ABC transporter signature motif; other site 748671005895 Walker B; other site 748671005896 D-loop; other site 748671005897 H-loop/switch region; other site 748671005898 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 748671005899 FtsX-like permease family; Region: FtsX; pfam02687 748671005900 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 748671005901 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 748671005902 FtsX-like permease family; Region: FtsX; pfam02687 748671005903 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 748671005904 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 748671005905 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 748671005906 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 748671005907 active site 748671005908 Protein of unknown function (DUF975); Region: DUF975; cl10504 748671005909 Beta-lactamase; Region: Beta-lactamase; pfam00144 748671005910 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 748671005911 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 748671005912 DltD N-terminal region; Region: DltD_N; pfam04915 748671005913 DltD central region; Region: DltD_M; pfam04918 748671005914 DltD C-terminal region; Region: DltD_C; pfam04914 748671005915 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 748671005916 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 748671005917 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 748671005918 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 748671005919 acyl-activating enzyme (AAE) consensus motif; other site 748671005920 AMP binding site [chemical binding]; other site 748671005921 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 748671005922 Uncharacterized conserved protein [Function unknown]; Region: COG3391 748671005923 FOG: CBS domain [General function prediction only]; Region: COG0517 748671005924 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 748671005925 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 748671005926 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 748671005927 Soluble P-type ATPase [General function prediction only]; Region: COG4087 748671005928 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 748671005929 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 748671005930 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 748671005931 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 748671005932 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 748671005933 Walker A/P-loop; other site 748671005934 ATP binding site [chemical binding]; other site 748671005935 Q-loop/lid; other site 748671005936 ABC transporter signature motif; other site 748671005937 Walker B; other site 748671005938 D-loop; other site 748671005939 H-loop/switch region; other site 748671005940 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 748671005941 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 748671005942 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 748671005943 non-specific DNA binding site [nucleotide binding]; other site 748671005944 salt bridge; other site 748671005945 sequence-specific DNA binding site [nucleotide binding]; other site 748671005946 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 748671005947 CAAX protease self-immunity; Region: Abi; pfam02517 748671005948 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 748671005949 putative active site [active] 748671005950 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 748671005951 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 748671005952 Walker A/P-loop; other site 748671005953 ATP binding site [chemical binding]; other site 748671005954 Q-loop/lid; other site 748671005955 ABC transporter signature motif; other site 748671005956 Walker B; other site 748671005957 D-loop; other site 748671005958 H-loop/switch region; other site 748671005959 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 748671005960 FtsX-like permease family; Region: FtsX; pfam02687 748671005961 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 748671005962 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 748671005963 Predicted membrane protein [Function unknown]; Region: COG4684 748671005964 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 748671005965 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 748671005966 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 748671005967 ligand binding site [chemical binding]; other site 748671005968 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 748671005969 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 748671005970 ligand binding site [chemical binding]; other site 748671005971 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 748671005972 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 748671005973 Walker A/P-loop; other site 748671005974 ATP binding site [chemical binding]; other site 748671005975 Q-loop/lid; other site 748671005976 ABC transporter signature motif; other site 748671005977 Walker B; other site 748671005978 D-loop; other site 748671005979 H-loop/switch region; other site 748671005980 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 748671005981 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 748671005982 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 748671005983 TM-ABC transporter signature motif; other site 748671005984 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 748671005985 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 748671005986 TM-ABC transporter signature motif; other site 748671005987 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 748671005988 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 748671005989 active site 748671005990 catalytic tetrad [active] 748671005991 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 748671005992 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 748671005993 active site 748671005994 trimer interface [polypeptide binding]; other site 748671005995 allosteric site; other site 748671005996 active site lid [active] 748671005997 hexamer (dimer of trimers) interface [polypeptide binding]; other site 748671005998 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 748671005999 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 748671006000 Substrate-binding site [chemical binding]; other site 748671006001 Substrate specificity [chemical binding]; other site 748671006002 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 748671006003 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 748671006004 Substrate-binding site [chemical binding]; other site 748671006005 Substrate specificity [chemical binding]; other site 748671006006 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748671006007 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 748671006008 active site 748671006009 motif I; other site 748671006010 motif II; other site 748671006011 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 748671006012 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 748671006013 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 748671006014 AAA domain; Region: AAA_14; pfam13173 748671006015 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 748671006016 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 748671006017 DNA binding residues [nucleotide binding] 748671006018 dimer interface [polypeptide binding]; other site 748671006019 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 748671006020 RelB antitoxin; Region: RelB; cl01171 748671006021 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 748671006022 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 748671006023 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 748671006024 AAA domain; Region: AAA_14; pfam13173 748671006025 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748671006026 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 748671006027 active site 748671006028 motif I; other site 748671006029 motif II; other site 748671006030 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 748671006031 motif II; other site 748671006032 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 748671006033 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 748671006034 Penicillinase repressor; Region: Pencillinase_R; pfam03965 748671006035 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 748671006036 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 748671006037 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 748671006038 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 748671006039 Soluble P-type ATPase [General function prediction only]; Region: COG4087 748671006040 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 748671006041 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 748671006042 ligand binding site [chemical binding]; other site 748671006043 flexible hinge region; other site 748671006044 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 748671006045 putative switch regulator; other site 748671006046 non-specific DNA interactions [nucleotide binding]; other site 748671006047 DNA binding site [nucleotide binding] 748671006048 sequence specific DNA binding site [nucleotide binding]; other site 748671006049 putative cAMP binding site [chemical binding]; other site 748671006050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748671006051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 748671006052 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 748671006053 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 748671006054 Cl- selectivity filter; other site 748671006055 Cl- binding residues [ion binding]; other site 748671006056 pore gating glutamate residue; other site 748671006057 dimer interface [polypeptide binding]; other site 748671006058 H+/Cl- coupling transport residue; other site 748671006059 TrkA-C domain; Region: TrkA_C; pfam02080 748671006060 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 748671006061 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 748671006062 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 748671006063 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 748671006064 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 748671006065 PYR/PP interface [polypeptide binding]; other site 748671006066 dimer interface [polypeptide binding]; other site 748671006067 tetramer interface [polypeptide binding]; other site 748671006068 TPP binding site [chemical binding]; other site 748671006069 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 748671006070 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 748671006071 TPP-binding site [chemical binding]; other site 748671006072 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 748671006073 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 748671006074 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 748671006075 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 748671006076 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 748671006077 trmE is a tRNA modification GTPase; Region: trmE; cd04164 748671006078 G1 box; other site 748671006079 GTP/Mg2+ binding site [chemical binding]; other site 748671006080 Switch I region; other site 748671006081 G2 box; other site 748671006082 Switch II region; other site 748671006083 G3 box; other site 748671006084 G4 box; other site 748671006085 G5 box; other site 748671006086 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 748671006087 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 748671006088 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 748671006089 ribonuclease P; Reviewed; Region: rnpA; PRK00499 748671006090 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399