-- dump date 20140619_123309 -- class Genbank::misc_feature -- table misc_feature_note -- id note 767455000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 767455000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 767455000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767455000004 Walker A motif; other site 767455000005 ATP binding site [chemical binding]; other site 767455000006 Walker B motif; other site 767455000007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 767455000008 arginine finger; other site 767455000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 767455000010 DnaA box-binding interface [nucleotide binding]; other site 767455000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 767455000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 767455000013 putative DNA binding surface [nucleotide binding]; other site 767455000014 dimer interface [polypeptide binding]; other site 767455000015 beta-clamp/clamp loader binding surface; other site 767455000016 beta-clamp/translesion DNA polymerase binding surface; other site 767455000017 S4 domain; Region: S4_2; pfam13275 767455000018 recombination protein F; Reviewed; Region: recF; PRK00064 767455000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 767455000020 Walker A/P-loop; other site 767455000021 ATP binding site [chemical binding]; other site 767455000022 Q-loop/lid; other site 767455000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767455000024 ABC transporter signature motif; other site 767455000025 Walker B; other site 767455000026 D-loop; other site 767455000027 H-loop/switch region; other site 767455000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 767455000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767455000030 Mg2+ binding site [ion binding]; other site 767455000031 G-X-G motif; other site 767455000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 767455000033 anchoring element; other site 767455000034 dimer interface [polypeptide binding]; other site 767455000035 ATP binding site [chemical binding]; other site 767455000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 767455000037 active site 767455000038 putative metal-binding site [ion binding]; other site 767455000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 767455000040 DNA gyrase subunit A; Validated; Region: PRK05560 767455000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 767455000042 CAP-like domain; other site 767455000043 active site 767455000044 primary dimer interface [polypeptide binding]; other site 767455000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767455000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767455000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767455000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767455000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767455000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767455000051 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 767455000052 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 767455000053 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 767455000054 dimer interface [polypeptide binding]; other site 767455000055 ssDNA binding site [nucleotide binding]; other site 767455000056 tetramer (dimer of dimers) interface [polypeptide binding]; other site 767455000057 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 767455000058 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 767455000059 DHH family; Region: DHH; pfam01368 767455000060 DHHA1 domain; Region: DHHA1; pfam02272 767455000061 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 767455000062 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 767455000063 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 767455000064 replicative DNA helicase; Region: DnaB; TIGR00665 767455000065 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 767455000066 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 767455000067 Walker A motif; other site 767455000068 ATP binding site [chemical binding]; other site 767455000069 Walker B motif; other site 767455000070 DNA binding loops [nucleotide binding] 767455000071 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 767455000072 nucleophilic elbow; other site 767455000073 catalytic triad; other site 767455000074 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767455000075 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767455000076 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767455000077 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 767455000078 MgtC family; Region: MgtC; pfam02308 767455000079 Predicted transcriptional regulator [Transcription]; Region: COG1959 767455000080 Transcriptional regulator; Region: Rrf2; pfam02082 767455000081 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 767455000082 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 767455000083 putative NAD(P) binding site [chemical binding]; other site 767455000084 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 767455000085 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767455000086 Walker A/P-loop; other site 767455000087 ATP binding site [chemical binding]; other site 767455000088 Q-loop/lid; other site 767455000089 ABC transporter signature motif; other site 767455000090 Walker B; other site 767455000091 D-loop; other site 767455000092 H-loop/switch region; other site 767455000093 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 767455000094 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 767455000095 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 767455000096 active site 767455000097 Bacterial surface layer protein; Region: SLAP; pfam03217 767455000098 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 767455000099 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767455000100 Coenzyme A binding pocket [chemical binding]; other site 767455000101 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 767455000102 substrate binding site [chemical binding]; other site 767455000103 ATP binding site [chemical binding]; other site 767455000104 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 767455000105 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 767455000106 PLD-like domain; Region: PLDc_2; pfam13091 767455000107 putative homodimer interface [polypeptide binding]; other site 767455000108 putative active site [active] 767455000109 catalytic site [active] 767455000110 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 767455000111 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767455000112 ATP binding site [chemical binding]; other site 767455000113 putative Mg++ binding site [ion binding]; other site 767455000114 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767455000115 nucleotide binding region [chemical binding]; other site 767455000116 ATP-binding site [chemical binding]; other site 767455000117 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 767455000118 Protein of unknown function (DUF975); Region: DUF975; cl10504 767455000119 YcxB-like protein; Region: YcxB; pfam14317 767455000120 Rrf2 family protein; Region: rrf2_super; TIGR00738 767455000121 Transcriptional regulator; Region: Rrf2; pfam02082 767455000122 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 767455000123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767455000124 NAD(P) binding site [chemical binding]; other site 767455000125 active site 767455000126 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 767455000127 active site 1 [active] 767455000128 dimer interface [polypeptide binding]; other site 767455000129 hexamer interface [polypeptide binding]; other site 767455000130 active site 2 [active] 767455000131 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 767455000132 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 767455000133 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 767455000134 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 767455000135 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 767455000136 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 767455000137 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 767455000138 DNA binding residues [nucleotide binding] 767455000139 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767455000140 Probable transposase; Region: OrfB_IS605; pfam01385 767455000141 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767455000142 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 767455000143 amphipathic channel; other site 767455000144 Asn-Pro-Ala signature motifs; other site 767455000145 Transcriptional regulators [Transcription]; Region: PurR; COG1609 767455000146 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 767455000147 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 767455000148 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 767455000149 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 767455000150 Ligand binding site; other site 767455000151 Putative Catalytic site; other site 767455000152 DXD motif; other site 767455000153 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 767455000154 EDD domain protein, DegV family; Region: DegV; TIGR00762 767455000155 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 767455000156 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 767455000157 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cd04761 767455000158 DNA binding residues [nucleotide binding] 767455000159 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 767455000160 catalytic residues [active] 767455000161 catalytic nucleophile [active] 767455000162 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767455000163 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767455000164 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 767455000165 catalytic triad [active] 767455000166 oxyanion hole [active] 767455000167 active site 767455000168 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767455000169 catalytic core [active] 767455000170 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767455000171 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 767455000172 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 767455000173 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767455000174 motif II; other site 767455000175 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 767455000176 active site 767455000177 DNA binding site [nucleotide binding] 767455000178 putative catalytic site [active] 767455000179 putative phosphate binding site [ion binding]; other site 767455000180 metal binding site A [ion binding]; metal-binding site 767455000181 AP binding site [nucleotide binding]; other site 767455000182 metal binding site B [ion binding]; metal-binding site 767455000183 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 767455000184 tetramer (dimer of dimers) interface [polypeptide binding]; other site 767455000185 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 767455000186 NAD binding site [chemical binding]; other site 767455000187 dimer interface [polypeptide binding]; other site 767455000188 substrate binding site [chemical binding]; other site 767455000189 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 767455000190 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 767455000191 active site 767455000192 catalytic tetrad [active] 767455000193 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 767455000194 Class II ribonucleotide reductase, monomeric form; Region: RNR_II_monomer; cd01676 767455000195 putative active site [active] 767455000196 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 767455000197 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 767455000198 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 767455000199 homodimer interface [polypeptide binding]; other site 767455000200 ligand binding site [chemical binding]; other site 767455000201 NAD binding site [chemical binding]; other site 767455000202 catalytic site [active] 767455000203 FAD binding domain; Region: FAD_binding_4; pfam01565 767455000204 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 767455000205 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 767455000206 active site 767455000207 catalytic residues [active] 767455000208 metal binding site [ion binding]; metal-binding site 767455000209 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 767455000210 S-ribosylhomocysteinase; Provisional; Region: PRK02260 767455000211 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 767455000212 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 767455000213 active site 767455000214 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 767455000215 Transposase; Region: DEDD_Tnp_IS110; pfam01548 767455000216 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 767455000217 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 767455000218 MutS domain III; Region: MutS_III; pfam05192 767455000219 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 767455000220 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767455000221 Walker A/P-loop; other site 767455000222 ATP binding site [chemical binding]; other site 767455000223 Q-loop/lid; other site 767455000224 ABC transporter signature motif; other site 767455000225 Walker B; other site 767455000226 D-loop; other site 767455000227 H-loop/switch region; other site 767455000228 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767455000229 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767455000230 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767455000231 dimerization interface [polypeptide binding]; other site 767455000232 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 767455000233 substrate binding site [chemical binding]; other site 767455000234 THF binding site; other site 767455000235 zinc-binding site [ion binding]; other site 767455000236 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 767455000237 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 767455000238 nucleotide binding site [chemical binding]; other site 767455000239 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 767455000240 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 767455000241 tetramer (dimer of dimers) interface [polypeptide binding]; other site 767455000242 NAD binding site [chemical binding]; other site 767455000243 dimer interface [polypeptide binding]; other site 767455000244 substrate binding site [chemical binding]; other site 767455000245 benzoate transport; Region: 2A0115; TIGR00895 767455000246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767455000247 putative substrate translocation pore; other site 767455000248 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767455000249 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767455000250 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 767455000251 putative dimerization interface [polypeptide binding]; other site 767455000252 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 767455000253 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 767455000254 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 767455000255 active site 767455000256 catalytic residue [active] 767455000257 dimer interface [polypeptide binding]; other site 767455000258 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 767455000259 shikimate binding site; other site 767455000260 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767455000261 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767455000262 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767455000263 dimerization interface [polypeptide binding]; other site 767455000264 FMN-binding domain; Region: FMN_bind; pfam04205 767455000265 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 767455000266 L-aspartate oxidase; Provisional; Region: PRK06175 767455000267 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 767455000268 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 767455000269 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 767455000270 AAA domain; Region: AAA_14; pfam13173 767455000271 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 767455000272 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767455000273 non-specific DNA binding site [nucleotide binding]; other site 767455000274 salt bridge; other site 767455000275 sequence-specific DNA binding site [nucleotide binding]; other site 767455000276 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 767455000277 Catalytic site [active] 767455000278 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767455000279 Helix-turn-helix domain; Region: HTH_38; pfam13936 767455000280 Integrase core domain; Region: rve; pfam00665 767455000281 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 767455000282 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 767455000283 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 767455000284 active site 767455000285 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 767455000286 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 767455000287 putative acyl-acceptor binding pocket; other site 767455000288 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 767455000289 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 767455000290 active site 767455000291 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 767455000292 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 767455000293 putative acyl-acceptor binding pocket; other site 767455000294 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767455000295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767455000296 active site 767455000297 phosphorylation site [posttranslational modification] 767455000298 intermolecular recognition site; other site 767455000299 dimerization interface [polypeptide binding]; other site 767455000300 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767455000301 DNA binding site [nucleotide binding] 767455000302 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 767455000303 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767455000304 dimerization interface [polypeptide binding]; other site 767455000305 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767455000306 putative active site [active] 767455000307 heme pocket [chemical binding]; other site 767455000308 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767455000309 dimer interface [polypeptide binding]; other site 767455000310 phosphorylation site [posttranslational modification] 767455000311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767455000312 ATP binding site [chemical binding]; other site 767455000313 Mg2+ binding site [ion binding]; other site 767455000314 G-X-G motif; other site 767455000315 YycH protein; Region: YycH; pfam07435 767455000316 YycH protein; Region: YycI; pfam09648 767455000317 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 767455000318 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 767455000319 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 767455000320 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 767455000321 protein binding site [polypeptide binding]; other site 767455000322 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 767455000323 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767455000324 non-specific DNA binding site [nucleotide binding]; other site 767455000325 salt bridge; other site 767455000326 sequence-specific DNA binding site [nucleotide binding]; other site 767455000327 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 767455000328 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 767455000329 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767455000330 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767455000331 Walker A/P-loop; other site 767455000332 ATP binding site [chemical binding]; other site 767455000333 Q-loop/lid; other site 767455000334 ABC transporter signature motif; other site 767455000335 Walker B; other site 767455000336 D-loop; other site 767455000337 H-loop/switch region; other site 767455000338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767455000339 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 767455000340 Walker A/P-loop; other site 767455000341 ATP binding site [chemical binding]; other site 767455000342 Q-loop/lid; other site 767455000343 ABC transporter signature motif; other site 767455000344 Walker B; other site 767455000345 D-loop; other site 767455000346 H-loop/switch region; other site 767455000347 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 767455000348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767455000349 putative substrate translocation pore; other site 767455000350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767455000351 Helix-turn-helix domain; Region: HTH_18; pfam12833 767455000352 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767455000353 Helix-turn-helix domain; Region: HTH_38; pfam13936 767455000354 Integrase core domain; Region: rve; pfam00665 767455000355 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767455000356 non-specific DNA binding site [nucleotide binding]; other site 767455000357 salt bridge; other site 767455000358 sequence-specific DNA binding site [nucleotide binding]; other site 767455000359 heat shock protein HtpX; Provisional; Region: PRK04897 767455000360 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 767455000361 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 767455000362 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 767455000363 transmembrane helices; other site 767455000364 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 767455000365 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 767455000366 active site 767455000367 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767455000368 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767455000369 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 767455000370 NlpC/P60 family; Region: NLPC_P60; pfam00877 767455000371 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 767455000372 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 767455000373 Walker A/P-loop; other site 767455000374 ATP binding site [chemical binding]; other site 767455000375 Q-loop/lid; other site 767455000376 ABC transporter signature motif; other site 767455000377 Walker B; other site 767455000378 D-loop; other site 767455000379 H-loop/switch region; other site 767455000380 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767455000381 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767455000382 substrate binding pocket [chemical binding]; other site 767455000383 membrane-bound complex binding site; other site 767455000384 hinge residues; other site 767455000385 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 767455000386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767455000387 dimer interface [polypeptide binding]; other site 767455000388 conserved gate region; other site 767455000389 putative PBP binding loops; other site 767455000390 ABC-ATPase subunit interface; other site 767455000391 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 767455000392 active site 767455000393 DNA binding site [nucleotide binding] 767455000394 Protein of unknown function, DUF488; Region: DUF488; cl01246 767455000395 NAD-dependent deacetylase; Provisional; Region: PRK00481 767455000396 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 767455000397 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 767455000398 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 767455000399 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 767455000400 putative active site [active] 767455000401 catalytic site [active] 767455000402 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 767455000403 putative active site [active] 767455000404 catalytic site [active] 767455000405 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 767455000406 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 767455000407 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 767455000408 RNA/DNA hybrid binding site [nucleotide binding]; other site 767455000409 active site 767455000410 Predicted secreted protein [Function unknown]; Region: COG4086 767455000411 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 767455000412 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 767455000413 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 767455000414 active site 767455000415 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 767455000416 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 767455000417 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 767455000418 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 767455000419 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767455000420 active site 767455000421 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767455000422 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767455000423 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 767455000424 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 767455000425 ligand binding site [chemical binding]; other site 767455000426 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 767455000427 non-specific DNA interactions [nucleotide binding]; other site 767455000428 DNA binding site [nucleotide binding] 767455000429 sequence specific DNA binding site [nucleotide binding]; other site 767455000430 putative cAMP binding site [chemical binding]; other site 767455000431 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 767455000432 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 767455000433 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 767455000434 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767455000435 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 767455000436 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 767455000437 DNA binding residues [nucleotide binding] 767455000438 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 767455000439 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 767455000440 DNA binding residues [nucleotide binding] 767455000441 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 767455000442 catalytic residues [active] 767455000443 catalytic nucleophile [active] 767455000444 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767455000445 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 767455000446 YibE/F-like protein; Region: YibE_F; pfam07907 767455000447 YibE/F-like protein; Region: YibE_F; pfam07907 767455000448 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 767455000449 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 767455000450 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767455000451 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 767455000452 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 767455000453 Ca binding site [ion binding]; other site 767455000454 active site 767455000455 catalytic site [active] 767455000456 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 767455000457 Transcriptional regulators [Transcription]; Region: PurR; COG1609 767455000458 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767455000459 DNA binding site [nucleotide binding] 767455000460 domain linker motif; other site 767455000461 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 767455000462 ligand binding site [chemical binding]; other site 767455000463 dimerization interface [polypeptide binding]; other site 767455000464 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 767455000465 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 767455000466 Ca binding site [ion binding]; other site 767455000467 active site 767455000468 catalytic site [active] 767455000469 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 767455000470 homodimer interface [polypeptide binding]; other site 767455000471 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 767455000472 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 767455000473 active site 767455000474 homodimer interface [polypeptide binding]; other site 767455000475 catalytic site [active] 767455000476 maltose phosphorylase; Provisional; Region: PRK13807 767455000477 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 767455000478 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 767455000479 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 767455000480 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 767455000481 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 767455000482 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 767455000483 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 767455000484 Walker A/P-loop; other site 767455000485 ATP binding site [chemical binding]; other site 767455000486 Q-loop/lid; other site 767455000487 ABC transporter signature motif; other site 767455000488 Walker B; other site 767455000489 D-loop; other site 767455000490 H-loop/switch region; other site 767455000491 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 767455000492 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 767455000493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767455000494 dimer interface [polypeptide binding]; other site 767455000495 conserved gate region; other site 767455000496 ABC-ATPase subunit interface; other site 767455000497 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 767455000498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767455000499 dimer interface [polypeptide binding]; other site 767455000500 conserved gate region; other site 767455000501 putative PBP binding loops; other site 767455000502 ABC-ATPase subunit interface; other site 767455000503 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 767455000504 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 767455000505 active site 767455000506 catalytic site [active] 767455000507 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 767455000508 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 767455000509 Interdomain contacts; other site 767455000510 Cytokine receptor motif; other site 767455000511 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 767455000512 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 767455000513 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 767455000514 active site 767455000515 dimer interface [polypeptide binding]; other site 767455000516 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 767455000517 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 767455000518 active site 767455000519 phosphorylation site [posttranslational modification] 767455000520 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 767455000521 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 767455000522 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 767455000523 Ligand Binding Site [chemical binding]; other site 767455000524 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 767455000525 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767455000526 membrane-bound complex binding site; other site 767455000527 hinge residues; other site 767455000528 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 767455000529 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 767455000530 Walker A/P-loop; other site 767455000531 ATP binding site [chemical binding]; other site 767455000532 Q-loop/lid; other site 767455000533 ABC transporter signature motif; other site 767455000534 Walker B; other site 767455000535 D-loop; other site 767455000536 H-loop/switch region; other site 767455000537 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 767455000538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767455000539 dimer interface [polypeptide binding]; other site 767455000540 conserved gate region; other site 767455000541 ABC-ATPase subunit interface; other site 767455000542 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 767455000543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767455000544 dimer interface [polypeptide binding]; other site 767455000545 conserved gate region; other site 767455000546 putative PBP binding loops; other site 767455000547 ABC-ATPase subunit interface; other site 767455000548 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767455000549 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767455000550 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767455000551 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767455000552 MULE transposase domain; Region: MULE; pfam10551 767455000553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 767455000554 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 767455000555 Transposase; Region: DEDD_Tnp_IS110; pfam01548 767455000556 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 767455000557 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 767455000558 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 767455000559 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767455000560 active site 767455000561 metal binding site [ion binding]; metal-binding site 767455000562 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 767455000563 active site 767455000564 dimer interface [polypeptide binding]; other site 767455000565 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 767455000566 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 767455000567 Ligand Binding Site [chemical binding]; other site 767455000568 Molecular Tunnel; other site 767455000569 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 767455000570 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 767455000571 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767455000572 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 767455000573 Class III ribonucleotide reductase; Region: RNR_III; cd01675 767455000574 effector binding site; other site 767455000575 active site 767455000576 Zn binding site [ion binding]; other site 767455000577 glycine loop; other site 767455000578 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 767455000579 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 767455000580 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 767455000581 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 767455000582 Uncharacterized conserved protein [Function unknown]; Region: COG2461 767455000583 Family of unknown function (DUF438); Region: DUF438; pfam04282 767455000584 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 767455000585 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767455000586 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767455000587 putative substrate translocation pore; other site 767455000588 Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545 767455000589 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 767455000590 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 767455000591 active site 767455000592 Zn binding site [ion binding]; other site 767455000593 K+ potassium transporter; Region: K_trans; pfam02705 767455000594 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 767455000595 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 767455000596 Bacterial surface layer protein; Region: SLAP; pfam03217 767455000597 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 767455000598 amidase catalytic site [active] 767455000599 Zn binding residues [ion binding]; other site 767455000600 substrate binding site [chemical binding]; other site 767455000601 Bacterial surface layer protein; Region: SLAP; pfam03217 767455000602 Bacterial surface layer protein; Region: SLAP; pfam03217 767455000603 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 767455000604 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 767455000605 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 767455000606 TrkA-N domain; Region: TrkA_N; pfam02254 767455000607 TrkA-C domain; Region: TrkA_C; pfam02080 767455000608 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 767455000609 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 767455000610 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767455000611 catalytic core [active] 767455000612 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767455000613 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 767455000614 membrane protein; Provisional; Region: PRK14411 767455000615 Sulfatase; Region: Sulfatase; cl17466 767455000616 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 767455000617 Acyltransferase family; Region: Acyl_transf_3; pfam01757 767455000618 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 767455000619 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 767455000620 active site 767455000621 HIGH motif; other site 767455000622 dimer interface [polypeptide binding]; other site 767455000623 KMSKS motif; other site 767455000624 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767455000625 RNA binding surface [nucleotide binding]; other site 767455000626 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767455000627 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 767455000628 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 767455000629 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 767455000630 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 767455000631 peptide binding site [polypeptide binding]; other site 767455000632 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 767455000633 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 767455000634 peptide binding site [polypeptide binding]; other site 767455000635 potential frameshift: common BLAST hit: gi|116513389|ref|YP_812295.1| ABC oligopeptide transporter periplasmic component 767455000636 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 767455000637 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 767455000638 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 767455000639 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 767455000640 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 767455000641 peptide binding site [polypeptide binding]; other site 767455000642 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767455000643 Helix-turn-helix domain; Region: HTH_38; pfam13936 767455000644 Integrase core domain; Region: rve; pfam00665 767455000645 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 767455000646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767455000647 dimer interface [polypeptide binding]; other site 767455000648 conserved gate region; other site 767455000649 putative PBP binding loops; other site 767455000650 ABC-ATPase subunit interface; other site 767455000651 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 767455000652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767455000653 dimer interface [polypeptide binding]; other site 767455000654 conserved gate region; other site 767455000655 putative PBP binding loops; other site 767455000656 ABC-ATPase subunit interface; other site 767455000657 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 767455000658 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 767455000659 Walker A/P-loop; other site 767455000660 ATP binding site [chemical binding]; other site 767455000661 Q-loop/lid; other site 767455000662 ABC transporter signature motif; other site 767455000663 Walker B; other site 767455000664 D-loop; other site 767455000665 H-loop/switch region; other site 767455000666 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 767455000667 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 767455000668 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 767455000669 Walker A/P-loop; other site 767455000670 ATP binding site [chemical binding]; other site 767455000671 Q-loop/lid; other site 767455000672 ABC transporter signature motif; other site 767455000673 Walker B; other site 767455000674 D-loop; other site 767455000675 H-loop/switch region; other site 767455000676 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 767455000677 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 767455000678 trimer interface [polypeptide binding]; other site 767455000679 active site 767455000680 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 767455000681 trimer interface [polypeptide binding]; other site 767455000682 active site 767455000683 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 767455000684 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 767455000685 putative dimer interface [polypeptide binding]; other site 767455000686 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 767455000687 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 767455000688 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 767455000689 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 767455000690 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 767455000691 GDP-binding site [chemical binding]; other site 767455000692 ACT binding site; other site 767455000693 IMP binding site; other site 767455000694 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 767455000695 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 767455000696 active site 767455000697 Transposase; Region: DEDD_Tnp_IS110; pfam01548 767455000698 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 767455000699 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 767455000700 DNA polymerase IV; Reviewed; Region: PRK03103 767455000701 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 767455000702 active site 767455000703 DNA binding site [nucleotide binding] 767455000704 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 767455000705 xanthine permease; Region: pbuX; TIGR03173 767455000706 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767455000707 active site 767455000708 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 767455000709 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 767455000710 active site 767455000711 GMP synthase; Reviewed; Region: guaA; PRK00074 767455000712 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 767455000713 AMP/PPi binding site [chemical binding]; other site 767455000714 candidate oxyanion hole; other site 767455000715 catalytic triad [active] 767455000716 potential glutamine specificity residues [chemical binding]; other site 767455000717 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 767455000718 ATP Binding subdomain [chemical binding]; other site 767455000719 Ligand Binding sites [chemical binding]; other site 767455000720 Dimerization subdomain; other site 767455000721 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 767455000722 HicB family; Region: HicB; pfam05534 767455000723 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 767455000724 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 767455000725 active site 767455000726 ATP binding site [chemical binding]; other site 767455000727 substrate binding site [chemical binding]; other site 767455000728 activation loop (A-loop); other site 767455000729 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 767455000730 active site 767455000731 zinc binding site [ion binding]; other site 767455000732 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 767455000733 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 767455000734 Walker A/P-loop; other site 767455000735 ATP binding site [chemical binding]; other site 767455000736 Q-loop/lid; other site 767455000737 ABC transporter signature motif; other site 767455000738 Walker B; other site 767455000739 D-loop; other site 767455000740 H-loop/switch region; other site 767455000741 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 767455000742 beta-galactosidase; Region: BGL; TIGR03356 767455000743 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767455000744 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767455000745 substrate binding pocket [chemical binding]; other site 767455000746 membrane-bound complex binding site; other site 767455000747 hinge residues; other site 767455000748 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 767455000749 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767455000750 Walker A/P-loop; other site 767455000751 ATP binding site [chemical binding]; other site 767455000752 Q-loop/lid; other site 767455000753 ABC transporter signature motif; other site 767455000754 Walker B; other site 767455000755 D-loop; other site 767455000756 H-loop/switch region; other site 767455000757 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 767455000758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767455000759 dimer interface [polypeptide binding]; other site 767455000760 conserved gate region; other site 767455000761 putative PBP binding loops; other site 767455000762 ABC-ATPase subunit interface; other site 767455000763 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 767455000764 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 767455000765 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 767455000766 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 767455000767 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 767455000768 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767455000769 putative DNA binding site [nucleotide binding]; other site 767455000770 S-methylmethionine transporter; Provisional; Region: PRK11387 767455000771 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 767455000772 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 767455000773 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 767455000774 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767455000775 MarR family; Region: MarR_2; pfam12802 767455000776 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 767455000777 active site 767455000778 homodimer interface [polypeptide binding]; other site 767455000779 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 767455000780 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767455000781 active site 767455000782 motif I; other site 767455000783 motif II; other site 767455000784 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 767455000785 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767455000786 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 767455000787 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 767455000788 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 767455000789 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 767455000790 active site 767455000791 Isochorismatase family; Region: Isochorismatase; pfam00857 767455000792 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 767455000793 catalytic triad [active] 767455000794 conserved cis-peptide bond; other site 767455000795 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 767455000796 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 767455000797 nudix motif; other site 767455000798 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 767455000799 Enterocin A Immunity; Region: EntA_Immun; pfam08951 767455000800 CAAX protease self-immunity; Region: Abi; pfam02517 767455000801 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 767455000802 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 767455000803 active site 767455000804 HIGH motif; other site 767455000805 dimer interface [polypeptide binding]; other site 767455000806 KMSKS motif; other site 767455000807 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 767455000808 catalytic motif [active] 767455000809 Zn binding site [ion binding]; other site 767455000810 magnesium-transporting ATPase; Provisional; Region: PRK15122 767455000811 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 767455000812 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767455000813 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 767455000814 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 767455000815 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 767455000816 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 767455000817 active site 767455000818 HIGH motif; other site 767455000819 KMSKS motif; other site 767455000820 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 767455000821 tRNA binding surface [nucleotide binding]; other site 767455000822 anticodon binding site; other site 767455000823 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 767455000824 dimer interface [polypeptide binding]; other site 767455000825 putative tRNA-binding site [nucleotide binding]; other site 767455000826 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 767455000827 active site 767455000828 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 767455000829 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 767455000830 putative active site [active] 767455000831 putative metal binding site [ion binding]; other site 767455000832 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 767455000833 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 767455000834 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 767455000835 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 767455000836 pur operon repressor; Provisional; Region: PRK09213 767455000837 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 767455000838 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767455000839 active site 767455000840 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 767455000841 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 767455000842 Substrate binding site; other site 767455000843 Mg++ binding site; other site 767455000844 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 767455000845 active site 767455000846 substrate binding site [chemical binding]; other site 767455000847 CoA binding site [chemical binding]; other site 767455000848 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 767455000849 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 767455000850 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767455000851 active site 767455000852 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 767455000853 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767455000854 Zn2+ binding site [ion binding]; other site 767455000855 Mg2+ binding site [ion binding]; other site 767455000856 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 767455000857 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 767455000858 CTP synthetase; Validated; Region: pyrG; PRK05380 767455000859 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 767455000860 Catalytic site [active] 767455000861 active site 767455000862 UTP binding site [chemical binding]; other site 767455000863 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 767455000864 active site 767455000865 putative oxyanion hole; other site 767455000866 catalytic triad [active] 767455000867 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 767455000868 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 767455000869 hinge; other site 767455000870 active site 767455000871 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 767455000872 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 767455000873 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 767455000874 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767455000875 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 767455000876 DEAD-like helicases superfamily; Region: DEXDc; smart00487 767455000877 ATP binding site [chemical binding]; other site 767455000878 Mg++ binding site [ion binding]; other site 767455000879 motif III; other site 767455000880 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767455000881 nucleotide binding region [chemical binding]; other site 767455000882 ATP-binding site [chemical binding]; other site 767455000883 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 767455000884 alanine racemase; Reviewed; Region: alr; PRK00053 767455000885 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 767455000886 active site 767455000887 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 767455000888 dimer interface [polypeptide binding]; other site 767455000889 substrate binding site [chemical binding]; other site 767455000890 catalytic residues [active] 767455000891 FOG: CBS domain [General function prediction only]; Region: COG0517 767455000892 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 767455000893 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 767455000894 putative active site [active] 767455000895 catalytic residue [active] 767455000896 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 767455000897 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 767455000898 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767455000899 ATP binding site [chemical binding]; other site 767455000900 putative Mg++ binding site [ion binding]; other site 767455000901 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767455000902 nucleotide binding region [chemical binding]; other site 767455000903 ATP-binding site [chemical binding]; other site 767455000904 TRCF domain; Region: TRCF; pfam03461 767455000905 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767455000906 RNA binding surface [nucleotide binding]; other site 767455000907 Septum formation initiator; Region: DivIC; pfam04977 767455000908 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 767455000909 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 767455000910 RNA binding site [nucleotide binding]; other site 767455000911 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 767455000912 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 767455000913 Ligand Binding Site [chemical binding]; other site 767455000914 TilS substrate C-terminal domain; Region: TilS_C; smart00977 767455000915 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 767455000916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767455000917 Walker A motif; other site 767455000918 ATP binding site [chemical binding]; other site 767455000919 Walker B motif; other site 767455000920 arginine finger; other site 767455000921 Peptidase family M41; Region: Peptidase_M41; pfam01434 767455000922 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 767455000923 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 767455000924 dimerization interface [polypeptide binding]; other site 767455000925 domain crossover interface; other site 767455000926 redox-dependent activation switch; other site 767455000927 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 767455000928 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 767455000929 peptide binding site [polypeptide binding]; other site 767455000930 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 767455000931 peptidase T; Region: peptidase-T; TIGR01882 767455000932 metal binding site [ion binding]; metal-binding site 767455000933 dimer interface [polypeptide binding]; other site 767455000934 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 767455000935 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 767455000936 FMN binding site [chemical binding]; other site 767455000937 active site 767455000938 catalytic residues [active] 767455000939 substrate binding site [chemical binding]; other site 767455000940 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 767455000941 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 767455000942 dimer interface [polypeptide binding]; other site 767455000943 putative anticodon binding site; other site 767455000944 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 767455000945 motif 1; other site 767455000946 active site 767455000947 motif 2; other site 767455000948 motif 3; other site 767455000949 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 767455000950 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 767455000951 metal binding site [ion binding]; metal-binding site 767455000952 active site 767455000953 I-site; other site 767455000954 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 767455000955 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 767455000956 homodimer interface [polypeptide binding]; other site 767455000957 substrate-cofactor binding pocket; other site 767455000958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767455000959 catalytic residue [active] 767455000960 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 767455000961 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 767455000962 Clp amino terminal domain; Region: Clp_N; pfam02861 767455000963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767455000964 Walker A motif; other site 767455000965 ATP binding site [chemical binding]; other site 767455000966 Walker B motif; other site 767455000967 arginine finger; other site 767455000968 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767455000969 Walker A motif; other site 767455000970 ATP binding site [chemical binding]; other site 767455000971 Walker B motif; other site 767455000972 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 767455000973 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 767455000974 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 767455000975 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 767455000976 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 767455000977 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 767455000978 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 767455000979 RPB10 interaction site [polypeptide binding]; other site 767455000980 RPB1 interaction site [polypeptide binding]; other site 767455000981 RPB11 interaction site [polypeptide binding]; other site 767455000982 RPB3 interaction site [polypeptide binding]; other site 767455000983 RPB12 interaction site [polypeptide binding]; other site 767455000984 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 767455000985 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 767455000986 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 767455000987 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 767455000988 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 767455000989 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 767455000990 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 767455000991 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 767455000992 G-loop; other site 767455000993 DNA binding site [nucleotide binding] 767455000994 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 767455000995 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 767455000996 S17 interaction site [polypeptide binding]; other site 767455000997 S8 interaction site; other site 767455000998 16S rRNA interaction site [nucleotide binding]; other site 767455000999 streptomycin interaction site [chemical binding]; other site 767455001000 23S rRNA interaction site [nucleotide binding]; other site 767455001001 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 767455001002 30S ribosomal protein S7; Validated; Region: PRK05302 767455001003 elongation factor G; Reviewed; Region: PRK12739 767455001004 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 767455001005 G1 box; other site 767455001006 putative GEF interaction site [polypeptide binding]; other site 767455001007 GTP/Mg2+ binding site [chemical binding]; other site 767455001008 Switch I region; other site 767455001009 G2 box; other site 767455001010 G3 box; other site 767455001011 Switch II region; other site 767455001012 G4 box; other site 767455001013 G5 box; other site 767455001014 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 767455001015 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 767455001016 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 767455001017 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767455001018 Helix-turn-helix domain; Region: HTH_38; pfam13936 767455001019 Integrase core domain; Region: rve; pfam00665 767455001020 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 767455001021 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 767455001022 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 767455001023 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 767455001024 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 767455001025 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 767455001026 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 767455001027 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 767455001028 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 767455001029 putative translocon binding site; other site 767455001030 protein-rRNA interface [nucleotide binding]; other site 767455001031 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 767455001032 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 767455001033 G-X-X-G motif; other site 767455001034 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 767455001035 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 767455001036 23S rRNA interface [nucleotide binding]; other site 767455001037 5S rRNA interface [nucleotide binding]; other site 767455001038 putative antibiotic binding site [chemical binding]; other site 767455001039 L25 interface [polypeptide binding]; other site 767455001040 L27 interface [polypeptide binding]; other site 767455001041 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 767455001042 23S rRNA interface [nucleotide binding]; other site 767455001043 putative translocon interaction site; other site 767455001044 signal recognition particle (SRP54) interaction site; other site 767455001045 L23 interface [polypeptide binding]; other site 767455001046 trigger factor interaction site; other site 767455001047 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 767455001048 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 767455001049 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 767455001050 RNA binding site [nucleotide binding]; other site 767455001051 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 767455001052 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 767455001053 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 767455001054 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 767455001055 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 767455001056 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 767455001057 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 767455001058 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 767455001059 5S rRNA interface [nucleotide binding]; other site 767455001060 L27 interface [polypeptide binding]; other site 767455001061 23S rRNA interface [nucleotide binding]; other site 767455001062 L5 interface [polypeptide binding]; other site 767455001063 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 767455001064 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 767455001065 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 767455001066 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 767455001067 23S rRNA binding site [nucleotide binding]; other site 767455001068 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 767455001069 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 767455001070 SecY translocase; Region: SecY; pfam00344 767455001071 adenylate kinase; Reviewed; Region: adk; PRK00279 767455001072 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 767455001073 AMP-binding site [chemical binding]; other site 767455001074 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 767455001075 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 767455001076 rRNA binding site [nucleotide binding]; other site 767455001077 predicted 30S ribosome binding site; other site 767455001078 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 767455001079 30S ribosomal protein S13; Region: bact_S13; TIGR03631 767455001080 30S ribosomal protein S11; Validated; Region: PRK05309 767455001081 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 767455001082 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 767455001083 alphaNTD homodimer interface [polypeptide binding]; other site 767455001084 alphaNTD - beta interaction site [polypeptide binding]; other site 767455001085 alphaNTD - beta' interaction site [polypeptide binding]; other site 767455001086 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 767455001087 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 767455001088 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13640 767455001089 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767455001090 Walker A/P-loop; other site 767455001091 ATP binding site [chemical binding]; other site 767455001092 Q-loop/lid; other site 767455001093 ABC transporter signature motif; other site 767455001094 Walker B; other site 767455001095 D-loop; other site 767455001096 H-loop/switch region; other site 767455001097 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13641 767455001098 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767455001099 Walker A/P-loop; other site 767455001100 ATP binding site [chemical binding]; other site 767455001101 Q-loop/lid; other site 767455001102 ABC transporter signature motif; other site 767455001103 Walker B; other site 767455001104 D-loop; other site 767455001105 H-loop/switch region; other site 767455001106 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 767455001107 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 767455001108 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 767455001109 dimerization interface 3.5A [polypeptide binding]; other site 767455001110 active site 767455001111 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 767455001112 23S rRNA interface [nucleotide binding]; other site 767455001113 L3 interface [polypeptide binding]; other site 767455001114 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 767455001115 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767455001116 active site 767455001117 DNA binding site [nucleotide binding] 767455001118 Int/Topo IB signature motif; other site 767455001119 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 767455001120 DEAD-like helicases superfamily; Region: DEXDc; smart00487 767455001121 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767455001122 ATP binding site [chemical binding]; other site 767455001123 putative Mg++ binding site [ion binding]; other site 767455001124 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 767455001125 nucleotide binding region [chemical binding]; other site 767455001126 ATP-binding site [chemical binding]; other site 767455001127 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 767455001128 HsdM N-terminal domain; Region: HsdM_N; pfam12161 767455001129 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 767455001130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767455001131 S-adenosylmethionine binding site [chemical binding]; other site 767455001132 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 767455001133 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 767455001134 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 767455001135 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 767455001136 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 767455001137 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 767455001138 peptide binding site [polypeptide binding]; other site 767455001139 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 767455001140 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 767455001141 nudix motif; other site 767455001142 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 767455001143 substrate binding site [chemical binding]; other site 767455001144 aromatic amino acid aminotransferase; Validated; Region: PRK07309 767455001145 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767455001146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767455001147 homodimer interface [polypeptide binding]; other site 767455001148 catalytic residue [active] 767455001149 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 767455001150 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 767455001151 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 767455001152 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 767455001153 peptide binding site [polypeptide binding]; other site 767455001154 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 767455001155 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 767455001156 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767455001157 DNA-binding site [nucleotide binding]; DNA binding site 767455001158 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 767455001159 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 767455001160 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 767455001161 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 767455001162 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 767455001163 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 767455001164 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 767455001165 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767455001166 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 767455001167 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 767455001168 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 767455001169 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 767455001170 homodimer interface [polypeptide binding]; other site 767455001171 NAD binding pocket [chemical binding]; other site 767455001172 ATP binding pocket [chemical binding]; other site 767455001173 Mg binding site [ion binding]; other site 767455001174 active-site loop [active] 767455001175 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 767455001176 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 767455001177 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767455001178 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 767455001179 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767455001180 motif II; other site 767455001181 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 767455001182 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767455001183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767455001184 Walker A/P-loop; other site 767455001185 ATP binding site [chemical binding]; other site 767455001186 Q-loop/lid; other site 767455001187 ABC transporter signature motif; other site 767455001188 H-loop/switch region; other site 767455001189 SprT homologues; Region: SprT; cl01182 767455001190 hypothetical protein; Provisional; Region: PRK04351 767455001191 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 767455001192 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 767455001193 Part of AAA domain; Region: AAA_19; pfam13245 767455001194 Family description; Region: UvrD_C_2; pfam13538 767455001195 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 767455001196 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 767455001197 nucleotide binding pocket [chemical binding]; other site 767455001198 K-X-D-G motif; other site 767455001199 catalytic site [active] 767455001200 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 767455001201 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 767455001202 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 767455001203 Dimer interface [polypeptide binding]; other site 767455001204 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 767455001205 putative dimer interface [polypeptide binding]; other site 767455001206 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 767455001207 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 767455001208 putative dimer interface [polypeptide binding]; other site 767455001209 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 767455001210 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 767455001211 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 767455001212 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 767455001213 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 767455001214 GatB domain; Region: GatB_Yqey; smart00845 767455001215 putative lipid kinase; Reviewed; Region: PRK13337 767455001216 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 767455001217 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 767455001218 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 767455001219 TRAM domain; Region: TRAM; pfam01938 767455001220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767455001221 S-adenosylmethionine binding site [chemical binding]; other site 767455001222 Mrr N-terminal domain; Region: Mrr_N; pfam14338 767455001223 Restriction endonuclease; Region: Mrr_cat; pfam04471 767455001224 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 767455001225 active site 767455001226 zinc binding site [ion binding]; other site 767455001227 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 767455001228 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 767455001229 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767455001230 Soluble P-type ATPase [General function prediction only]; Region: COG4087 767455001231 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 767455001232 metal-binding site [ion binding] 767455001233 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 767455001234 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 767455001235 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 767455001236 ligand binding site [chemical binding]; other site 767455001237 flexible hinge region; other site 767455001238 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 767455001239 putative switch regulator; other site 767455001240 non-specific DNA interactions [nucleotide binding]; other site 767455001241 DNA binding site [nucleotide binding] 767455001242 sequence specific DNA binding site [nucleotide binding]; other site 767455001243 putative cAMP binding site [chemical binding]; other site 767455001244 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 767455001245 Uncharacterized conserved protein [Function unknown]; Region: COG1359 767455001246 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 767455001247 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767455001248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767455001249 motif II; other site 767455001250 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 767455001251 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 767455001252 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 767455001253 active site 767455001254 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 767455001255 putative NADH binding site [chemical binding]; other site 767455001256 putative active site [active] 767455001257 nudix motif; other site 767455001258 putative metal binding site [ion binding]; other site 767455001259 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 767455001260 metal binding site [ion binding]; metal-binding site 767455001261 active site 767455001262 I-site; other site 767455001263 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 767455001264 RRXRR protein; Region: RRXRR; pfam14239 767455001265 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 767455001266 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 767455001267 active site 767455001268 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 767455001269 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 767455001270 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 767455001271 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 767455001272 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767455001273 putative DNA binding site [nucleotide binding]; other site 767455001274 putative Zn2+ binding site [ion binding]; other site 767455001275 AsnC family; Region: AsnC_trans_reg; pfam01037 767455001276 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 767455001277 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 767455001278 glutaminase active site [active] 767455001279 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 767455001280 dimer interface [polypeptide binding]; other site 767455001281 active site 767455001282 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 767455001283 dimer interface [polypeptide binding]; other site 767455001284 active site 767455001285 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 767455001286 HTH domain; Region: HTH_11; pfam08279 767455001287 Mga helix-turn-helix domain; Region: Mga; pfam05043 767455001288 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 767455001289 active site 767455001290 P-loop; other site 767455001291 phosphorylation site [posttranslational modification] 767455001292 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 767455001293 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 767455001294 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 767455001295 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 767455001296 active site 767455001297 P-loop; other site 767455001298 phosphorylation site [posttranslational modification] 767455001299 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 767455001300 active site 767455001301 P-loop; other site 767455001302 phosphorylation site [posttranslational modification] 767455001303 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 767455001304 active site 767455001305 phosphorylation site [posttranslational modification] 767455001306 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 767455001307 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 767455001308 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 767455001309 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 767455001310 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 767455001311 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 767455001312 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767455001313 Walker A/P-loop; other site 767455001314 ATP binding site [chemical binding]; other site 767455001315 Q-loop/lid; other site 767455001316 ABC transporter signature motif; other site 767455001317 Walker B; other site 767455001318 D-loop; other site 767455001319 H-loop/switch region; other site 767455001320 ABC transporter; Region: ABC_tran_2; pfam12848 767455001321 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767455001322 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767455001323 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767455001324 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 767455001325 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cd04761 767455001326 DNA binding residues [nucleotide binding] 767455001327 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 767455001328 catalytic residues [active] 767455001329 catalytic nucleophile [active] 767455001330 drug efflux system protein MdtG; Provisional; Region: PRK09874 767455001331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767455001332 putative substrate translocation pore; other site 767455001333 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 767455001334 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 767455001335 glutamate racemase; Provisional; Region: PRK00865 767455001336 Peptidase family C69; Region: Peptidase_C69; pfam03577 767455001337 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 767455001338 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 767455001339 oligomer interface [polypeptide binding]; other site 767455001340 active site 767455001341 metal binding site [ion binding]; metal-binding site 767455001342 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 767455001343 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 767455001344 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 767455001345 ATP-binding site [chemical binding]; other site 767455001346 Sugar specificity; other site 767455001347 Pyrimidine base specificity; other site 767455001348 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 767455001349 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 767455001350 Sugar specificity; other site 767455001351 Pyrimidine base specificity; other site 767455001352 ATP-binding site [chemical binding]; other site 767455001353 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 767455001354 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 767455001355 Walker A/P-loop; other site 767455001356 ATP binding site [chemical binding]; other site 767455001357 Q-loop/lid; other site 767455001358 ABC transporter signature motif; other site 767455001359 Walker B; other site 767455001360 D-loop; other site 767455001361 H-loop/switch region; other site 767455001362 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767455001363 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767455001364 substrate binding pocket [chemical binding]; other site 767455001365 membrane-bound complex binding site; other site 767455001366 hinge residues; other site 767455001367 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 767455001368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767455001369 dimer interface [polypeptide binding]; other site 767455001370 conserved gate region; other site 767455001371 putative PBP binding loops; other site 767455001372 ABC-ATPase subunit interface; other site 767455001373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767455001374 dimer interface [polypeptide binding]; other site 767455001375 conserved gate region; other site 767455001376 putative PBP binding loops; other site 767455001377 ABC-ATPase subunit interface; other site 767455001378 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767455001379 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767455001380 substrate binding pocket [chemical binding]; other site 767455001381 membrane-bound complex binding site; other site 767455001382 hinge residues; other site 767455001383 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 767455001384 polyphosphate kinase; Provisional; Region: PRK05443 767455001385 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 767455001386 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 767455001387 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 767455001388 putative domain interface [polypeptide binding]; other site 767455001389 putative active site [active] 767455001390 catalytic site [active] 767455001391 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 767455001392 putative domain interface [polypeptide binding]; other site 767455001393 putative active site [active] 767455001394 catalytic site [active] 767455001395 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 767455001396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 767455001397 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 767455001398 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 767455001399 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 767455001400 substrate binding site [chemical binding]; other site 767455001401 dimer interface [polypeptide binding]; other site 767455001402 ATP binding site [chemical binding]; other site 767455001403 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 767455001404 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 767455001405 substrate binding site [chemical binding]; other site 767455001406 hexamer interface [polypeptide binding]; other site 767455001407 metal binding site [ion binding]; metal-binding site 767455001408 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 767455001409 tetramer (dimer of dimers) interface [polypeptide binding]; other site 767455001410 active site 767455001411 dimer interface [polypeptide binding]; other site 767455001412 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 767455001413 active site 767455001414 tetramer interface [polypeptide binding]; other site 767455001415 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767455001416 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 767455001417 DNA-binding site [nucleotide binding]; DNA binding site 767455001418 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 767455001419 putative phosphoketolase; Provisional; Region: PRK05261 767455001420 XFP N-terminal domain; Region: XFP_N; pfam09364 767455001421 XFP C-terminal domain; Region: XFP_C; pfam09363 767455001422 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 767455001423 Domain of unknown function DUF21; Region: DUF21; pfam01595 767455001424 FOG: CBS domain [General function prediction only]; Region: COG0517 767455001425 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 767455001426 Transporter associated domain; Region: CorC_HlyC; smart01091 767455001427 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767455001428 active site 767455001429 amino acid transporter; Region: 2A0306; TIGR00909 767455001430 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 767455001431 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 767455001432 active site 767455001433 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 767455001434 DEAD-like helicases superfamily; Region: DEXDc; smart00487 767455001435 ATP binding site [chemical binding]; other site 767455001436 putative Mg++ binding site [ion binding]; other site 767455001437 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767455001438 nucleotide binding region [chemical binding]; other site 767455001439 ATP-binding site [chemical binding]; other site 767455001440 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 767455001441 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 767455001442 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 767455001443 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 767455001444 uracil transporter; Provisional; Region: PRK10720 767455001445 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 767455001446 Aluminium resistance protein; Region: Alum_res; pfam06838 767455001447 putative ornithine decarboxylase; Region: lacto_ODC_hypo; TIGR04318 767455001448 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 767455001449 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767455001450 catalytic residue [active] 767455001451 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 767455001452 Amino acid permease; Region: AA_permease_2; pfam13520 767455001453 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 767455001454 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 767455001455 active site 767455001456 homodimer interface [polypeptide binding]; other site 767455001457 Predicted membrane protein [Function unknown]; Region: COG2246 767455001458 GtrA-like protein; Region: GtrA; pfam04138 767455001459 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 767455001460 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 767455001461 methionine aminopeptidase; Provisional; Region: PRK08671 767455001462 active site 767455001463 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 767455001464 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 767455001465 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 767455001466 active site 767455001467 tetramer interface; other site 767455001468 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 767455001469 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 767455001470 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 767455001471 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 767455001472 TRAM domain; Region: TRAM; pfam01938 767455001473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767455001474 S-adenosylmethionine binding site [chemical binding]; other site 767455001475 recombination regulator RecX; Provisional; Region: recX; PRK14135 767455001476 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 767455001477 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 767455001478 Transporter associated domain; Region: CorC_HlyC; smart01091 767455001479 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 767455001480 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 767455001481 G1 box; other site 767455001482 putative GEF interaction site [polypeptide binding]; other site 767455001483 GTP/Mg2+ binding site [chemical binding]; other site 767455001484 Switch I region; other site 767455001485 G2 box; other site 767455001486 G3 box; other site 767455001487 Switch II region; other site 767455001488 G4 box; other site 767455001489 G5 box; other site 767455001490 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 767455001491 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 767455001492 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 767455001493 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 767455001494 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 767455001495 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767455001496 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 767455001497 Walker A motif; other site 767455001498 ATP binding site [chemical binding]; other site 767455001499 Walker B motif; other site 767455001500 arginine finger; other site 767455001501 UvrB/uvrC motif; Region: UVR; pfam02151 767455001502 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767455001503 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 767455001504 Walker A motif; other site 767455001505 ATP binding site [chemical binding]; other site 767455001506 Walker B motif; other site 767455001507 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 767455001508 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 767455001509 dimerization domain swap beta strand [polypeptide binding]; other site 767455001510 regulatory protein interface [polypeptide binding]; other site 767455001511 active site 767455001512 regulatory phosphorylation site [posttranslational modification]; other site 767455001513 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 767455001514 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 767455001515 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 767455001516 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 767455001517 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 767455001518 ArsC family; Region: ArsC; pfam03960 767455001519 putative catalytic residues [active] 767455001520 thiol/disulfide switch; other site 767455001521 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 767455001522 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767455001523 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 767455001524 MucBP domain; Region: MucBP; pfam06458 767455001525 MucBP domain; Region: MucBP; pfam06458 767455001526 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 767455001527 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 767455001528 Transposase; Region: DEDD_Tnp_IS110; pfam01548 767455001529 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 767455001530 Competence protein CoiA-like family; Region: CoiA; cl11541 767455001531 Thioredoxin; Region: Thioredoxin_5; pfam13743 767455001532 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 767455001533 putative active site [active] 767455001534 putative metal binding residues [ion binding]; other site 767455001535 signature motif; other site 767455001536 putative triphosphate binding site [ion binding]; other site 767455001537 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 767455001538 synthetase active site [active] 767455001539 NTP binding site [chemical binding]; other site 767455001540 metal binding site [ion binding]; metal-binding site 767455001541 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 767455001542 ATP-NAD kinase; Region: NAD_kinase; pfam01513 767455001543 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 767455001544 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 767455001545 active site 767455001546 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 767455001547 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 767455001548 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 767455001549 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 767455001550 Domain of unknown function DUF20; Region: UPF0118; pfam01594 767455001551 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 767455001552 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 767455001553 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 767455001554 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 767455001555 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 767455001556 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 767455001557 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 767455001558 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 767455001559 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 767455001560 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 767455001561 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 767455001562 classical (c) SDRs; Region: SDR_c; cd05233 767455001563 NAD(P) binding site [chemical binding]; other site 767455001564 active site 767455001565 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 767455001566 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767455001567 non-specific DNA binding site [nucleotide binding]; other site 767455001568 salt bridge; other site 767455001569 sequence-specific DNA binding site [nucleotide binding]; other site 767455001570 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 767455001571 recombinase A; Provisional; Region: recA; PRK09354 767455001572 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 767455001573 hexamer interface [polypeptide binding]; other site 767455001574 Walker A motif; other site 767455001575 ATP binding site [chemical binding]; other site 767455001576 Walker B motif; other site 767455001577 phosphodiesterase; Provisional; Region: PRK12704 767455001578 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767455001579 Zn2+ binding site [ion binding]; other site 767455001580 Mg2+ binding site [ion binding]; other site 767455001581 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 767455001582 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 767455001583 Mg++ binding site [ion binding]; other site 767455001584 putative catalytic motif [active] 767455001585 substrate binding site [chemical binding]; other site 767455001586 Uncharacterized conserved protein [Function unknown]; Region: COG1739 767455001587 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 767455001588 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 767455001589 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 767455001590 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767455001591 ATP binding site [chemical binding]; other site 767455001592 putative Mg++ binding site [ion binding]; other site 767455001593 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767455001594 nucleotide binding region [chemical binding]; other site 767455001595 ATP-binding site [chemical binding]; other site 767455001596 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 767455001597 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767455001598 active site 767455001599 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 767455001600 30S subunit binding site; other site 767455001601 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 767455001602 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 767455001603 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767455001604 nucleotide binding region [chemical binding]; other site 767455001605 ATP-binding site [chemical binding]; other site 767455001606 peptide chain release factor 2; Provisional; Region: PRK05589 767455001607 This domain is found in peptide chain release factors; Region: PCRF; smart00937 767455001608 RF-1 domain; Region: RF-1; pfam00472 767455001609 HPr kinase/phosphorylase; Provisional; Region: PRK05428 767455001610 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 767455001611 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 767455001612 Hpr binding site; other site 767455001613 active site 767455001614 homohexamer subunit interaction site [polypeptide binding]; other site 767455001615 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 767455001616 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 767455001617 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 767455001618 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 767455001619 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 767455001620 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767455001621 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767455001622 excinuclease ABC subunit B; Provisional; Region: PRK05298 767455001623 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767455001624 ATP binding site [chemical binding]; other site 767455001625 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767455001626 nucleotide binding region [chemical binding]; other site 767455001627 ATP-binding site [chemical binding]; other site 767455001628 Ultra-violet resistance protein B; Region: UvrB; pfam12344 767455001629 UvrB/uvrC motif; Region: UVR; pfam02151 767455001630 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 767455001631 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 767455001632 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 767455001633 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 767455001634 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 767455001635 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 767455001636 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 767455001637 homotetramer interface [polypeptide binding]; other site 767455001638 active site pocket [active] 767455001639 cleavage site 767455001640 homodimer interface [polypeptide binding]; other site 767455001641 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 767455001642 AAA domain; Region: AAA_18; pfam13238 767455001643 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 767455001644 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 767455001645 phosphate binding site [ion binding]; other site 767455001646 putative substrate binding pocket [chemical binding]; other site 767455001647 dimer interface [polypeptide binding]; other site 767455001648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 767455001649 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 767455001650 Clp protease; Region: CLP_protease; pfam00574 767455001651 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 767455001652 oligomer interface [polypeptide binding]; other site 767455001653 active site residues [active] 767455001654 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 767455001655 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 767455001656 zinc binding site [ion binding]; other site 767455001657 putative ligand binding site [chemical binding]; other site 767455001658 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 767455001659 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 767455001660 TM-ABC transporter signature motif; other site 767455001661 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 767455001662 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767455001663 Walker A/P-loop; other site 767455001664 ATP binding site [chemical binding]; other site 767455001665 Q-loop/lid; other site 767455001666 ABC transporter signature motif; other site 767455001667 Walker B; other site 767455001668 D-loop; other site 767455001669 H-loop/switch region; other site 767455001670 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 767455001671 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 767455001672 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 767455001673 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 767455001674 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 767455001675 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 767455001676 Phosphoglycerate kinase; Region: PGK; pfam00162 767455001677 substrate binding site [chemical binding]; other site 767455001678 hinge regions; other site 767455001679 ADP binding site [chemical binding]; other site 767455001680 catalytic site [active] 767455001681 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 767455001682 triosephosphate isomerase; Provisional; Region: PRK14567 767455001683 substrate binding site [chemical binding]; other site 767455001684 dimer interface [polypeptide binding]; other site 767455001685 catalytic triad [active] 767455001686 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 767455001687 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767455001688 Coenzyme A binding pocket [chemical binding]; other site 767455001689 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767455001690 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 767455001691 active site 767455001692 motif I; other site 767455001693 motif II; other site 767455001694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767455001695 motif II; other site 767455001696 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 767455001697 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 767455001698 ligand binding site [chemical binding]; other site 767455001699 active site 767455001700 UGI interface [polypeptide binding]; other site 767455001701 catalytic site [active] 767455001702 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 767455001703 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 767455001704 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 767455001705 active site 767455001706 catalytic site [active] 767455001707 substrate binding site [chemical binding]; other site 767455001708 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 767455001709 FAD binding domain; Region: FAD_binding_4; pfam01565 767455001710 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 767455001711 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 767455001712 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 767455001713 Walker A/P-loop; other site 767455001714 ATP binding site [chemical binding]; other site 767455001715 Q-loop/lid; other site 767455001716 ABC transporter signature motif; other site 767455001717 Walker B; other site 767455001718 D-loop; other site 767455001719 H-loop/switch region; other site 767455001720 TOBE domain; Region: TOBE_2; pfam08402 767455001721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767455001722 dimer interface [polypeptide binding]; other site 767455001723 conserved gate region; other site 767455001724 putative PBP binding loops; other site 767455001725 ABC-ATPase subunit interface; other site 767455001726 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 767455001727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767455001728 dimer interface [polypeptide binding]; other site 767455001729 conserved gate region; other site 767455001730 ABC-ATPase subunit interface; other site 767455001731 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 767455001732 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 767455001733 Uncharacterized conserved protein [Function unknown]; Region: COG1624 767455001734 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 767455001735 YbbR-like protein; Region: YbbR; pfam07949 767455001736 YbbR-like protein; Region: YbbR; pfam07949 767455001737 YbbR-like protein; Region: YbbR; pfam07949 767455001738 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 767455001739 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 767455001740 active site 767455001741 substrate binding site [chemical binding]; other site 767455001742 metal binding site [ion binding]; metal-binding site 767455001743 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 767455001744 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767455001745 active site 767455001746 motif I; other site 767455001747 motif II; other site 767455001748 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 767455001749 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 767455001750 Beta-lactamase; Region: Beta-lactamase; pfam00144 767455001751 Penicillinase repressor; Region: Pencillinase_R; pfam03965 767455001752 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 767455001753 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 767455001754 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767455001755 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767455001756 motif II; other site 767455001757 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 767455001758 camphor resistance protein CrcB; Provisional; Region: PRK14220 767455001759 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 767455001760 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 767455001761 metal binding site [ion binding]; metal-binding site 767455001762 active site 767455001763 I-site; other site 767455001764 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 767455001765 Low molecular weight phosphatase family; Region: LMWPc; cd00115 767455001766 active site 767455001767 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767455001768 NADH(P)-binding; Region: NAD_binding_10; pfam13460 767455001769 NAD(P) binding site [chemical binding]; other site 767455001770 active site 767455001771 Amino acid permease; Region: AA_permease_2; pfam13520 767455001772 putative transposase OrfB; Reviewed; Region: PHA02517 767455001773 HTH-like domain; Region: HTH_21; pfam13276 767455001774 Integrase core domain; Region: rve; pfam00665 767455001775 Integrase core domain; Region: rve_2; pfam13333 767455001776 methionine sulfoxide reductase A; Provisional; Region: PRK14054 767455001777 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 767455001778 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 767455001779 active site 767455001780 nucleophile elbow; other site 767455001781 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 767455001782 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 767455001783 intersubunit interface [polypeptide binding]; other site 767455001784 Predicted integral membrane protein [Function unknown]; Region: COG5652 767455001785 hypothetical protein; Validated; Region: PRK00110 767455001786 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 767455001787 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 767455001788 Walker A motif; other site 767455001789 ATP binding site [chemical binding]; other site 767455001790 Walker B motif; other site 767455001791 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 767455001792 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 767455001793 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 767455001794 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 767455001795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767455001796 S-adenosylmethionine binding site [chemical binding]; other site 767455001797 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 767455001798 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 767455001799 propionate/acetate kinase; Provisional; Region: PRK12379 767455001800 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767455001801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767455001802 active site 767455001803 phosphorylation site [posttranslational modification] 767455001804 intermolecular recognition site; other site 767455001805 dimerization interface [polypeptide binding]; other site 767455001806 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767455001807 DNA binding site [nucleotide binding] 767455001808 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767455001809 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767455001810 dimerization interface [polypeptide binding]; other site 767455001811 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767455001812 dimer interface [polypeptide binding]; other site 767455001813 phosphorylation site [posttranslational modification] 767455001814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767455001815 ATP binding site [chemical binding]; other site 767455001816 Mg2+ binding site [ion binding]; other site 767455001817 G-X-G motif; other site 767455001818 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 767455001819 Sulfatase; Region: Sulfatase; pfam00884 767455001820 VanZ like family; Region: VanZ; cl01971 767455001821 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 767455001822 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 767455001823 active site 767455001824 dimer interface [polypeptide binding]; other site 767455001825 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 767455001826 dimer interface [polypeptide binding]; other site 767455001827 active site 767455001828 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 767455001829 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 767455001830 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 767455001831 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 767455001832 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 767455001833 Beta-lactamase; Region: Beta-lactamase; pfam00144 767455001834 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 767455001835 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767455001836 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 767455001837 thymidine kinase; Provisional; Region: PRK04296 767455001838 peptide chain release factor 1; Validated; Region: prfA; PRK00591 767455001839 This domain is found in peptide chain release factors; Region: PCRF; smart00937 767455001840 RF-1 domain; Region: RF-1; pfam00472 767455001841 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 767455001842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767455001843 S-adenosylmethionine binding site [chemical binding]; other site 767455001844 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 767455001845 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 767455001846 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767455001847 active site 767455001848 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 767455001849 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 767455001850 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 767455001851 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 767455001852 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 767455001853 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 767455001854 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 767455001855 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 767455001856 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 767455001857 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 767455001858 beta subunit interaction interface [polypeptide binding]; other site 767455001859 Walker A motif; other site 767455001860 ATP binding site [chemical binding]; other site 767455001861 Walker B motif; other site 767455001862 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 767455001863 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 767455001864 core domain interface [polypeptide binding]; other site 767455001865 delta subunit interface [polypeptide binding]; other site 767455001866 epsilon subunit interface [polypeptide binding]; other site 767455001867 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 767455001868 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 767455001869 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 767455001870 alpha subunit interaction interface [polypeptide binding]; other site 767455001871 Walker A motif; other site 767455001872 ATP binding site [chemical binding]; other site 767455001873 Walker B motif; other site 767455001874 inhibitor binding site; inhibition site 767455001875 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 767455001876 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 767455001877 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 767455001878 epsilon subunit interface [polypeptide binding]; other site 767455001879 LBP interface [polypeptide binding]; other site 767455001880 gamma subunit interface [polypeptide binding]; other site 767455001881 Protein of unknown function (DUF1146); Region: DUF1146; pfam06612 767455001882 rod shape-determining protein MreB; Provisional; Region: PRK13930 767455001883 MreB and similar proteins; Region: MreB_like; cd10225 767455001884 nucleotide binding site [chemical binding]; other site 767455001885 Mg binding site [ion binding]; other site 767455001886 putative protofilament interaction site [polypeptide binding]; other site 767455001887 RodZ interaction site [polypeptide binding]; other site 767455001888 hypothetical protein; Provisional; Region: PRK14379 767455001889 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 767455001890 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 767455001891 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 767455001892 Ligand Binding Site [chemical binding]; other site 767455001893 DDE superfamily endonuclease; Region: DDE_3; pfam13358 767455001894 Winged helix-turn helix; Region: HTH_29; pfam13551 767455001895 Helix-turn-helix domain; Region: HTH_28; pfam13518 767455001896 Homeodomain-like domain; Region: HTH_32; pfam13565 767455001897 recombination factor protein RarA; Reviewed; Region: PRK13342 767455001898 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767455001899 Walker A motif; other site 767455001900 ATP binding site [chemical binding]; other site 767455001901 Walker B motif; other site 767455001902 arginine finger; other site 767455001903 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 767455001904 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 767455001905 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 767455001906 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 767455001907 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767455001908 RNA binding surface [nucleotide binding]; other site 767455001909 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 767455001910 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 767455001911 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 767455001912 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767455001913 catalytic residue [active] 767455001914 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 767455001915 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 767455001916 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 767455001917 Ligand Binding Site [chemical binding]; other site 767455001918 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 767455001919 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767455001920 RNA binding surface [nucleotide binding]; other site 767455001921 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 767455001922 active site 767455001923 uracil binding [chemical binding]; other site 767455001924 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 767455001925 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767455001926 active site 767455001927 HIGH motif; other site 767455001928 nucleotide binding site [chemical binding]; other site 767455001929 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 767455001930 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 767455001931 active site 767455001932 KMSKS motif; other site 767455001933 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 767455001934 tRNA binding surface [nucleotide binding]; other site 767455001935 anticodon binding site; other site 767455001936 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 767455001937 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 767455001938 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767455001939 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767455001940 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 767455001941 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767455001942 motif II; other site 767455001943 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 767455001944 MPN+ (JAMM) motif; other site 767455001945 Zinc-binding site [ion binding]; other site 767455001946 rod shape-determining protein MreB; Provisional; Region: PRK13927 767455001947 MreB and similar proteins; Region: MreB_like; cd10225 767455001948 nucleotide binding site [chemical binding]; other site 767455001949 Mg binding site [ion binding]; other site 767455001950 putative protofilament interaction site [polypeptide binding]; other site 767455001951 RodZ interaction site [polypeptide binding]; other site 767455001952 rod shape-determining protein MreC; Provisional; Region: PRK13922 767455001953 Protein of unknown function (DUF904); Region: DUF904; cl11531 767455001954 rod shape-determining protein MreC; Region: MreC; pfam04085 767455001955 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 767455001956 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 767455001957 cell division protein MraZ; Reviewed; Region: PRK00326 767455001958 MraZ protein; Region: MraZ; pfam02381 767455001959 MraZ protein; Region: MraZ; pfam02381 767455001960 MraW methylase family; Region: Methyltransf_5; pfam01795 767455001961 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 767455001962 cell division protein FtsL; Region: ftsL_broad; TIGR02209 767455001963 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 767455001964 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 767455001965 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 767455001966 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 767455001967 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 767455001968 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 767455001969 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 767455001970 Mg++ binding site [ion binding]; other site 767455001971 putative catalytic motif [active] 767455001972 putative substrate binding site [chemical binding]; other site 767455001973 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 767455001974 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767455001975 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767455001976 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 767455001977 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 767455001978 active site 767455001979 homodimer interface [polypeptide binding]; other site 767455001980 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 767455001981 Cell division protein FtsQ; Region: FtsQ; pfam03799 767455001982 cell division protein FtsA; Region: ftsA; TIGR01174 767455001983 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 767455001984 nucleotide binding site [chemical binding]; other site 767455001985 Cell division protein FtsA; Region: FtsA; cl17206 767455001986 Cell division protein FtsA; Region: FtsA; pfam14450 767455001987 cell division protein FtsZ; Validated; Region: PRK09330 767455001988 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 767455001989 nucleotide binding site [chemical binding]; other site 767455001990 SulA interaction site; other site 767455001991 Protein of unknown function (DUF552); Region: DUF552; cl00775 767455001992 YGGT family; Region: YGGT; pfam02325 767455001993 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 767455001994 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767455001995 RNA binding surface [nucleotide binding]; other site 767455001996 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 767455001997 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767455001998 active site 767455001999 HIGH motif; other site 767455002000 nucleotide binding site [chemical binding]; other site 767455002001 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 767455002002 active site 767455002003 KMSKS motif; other site 767455002004 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 767455002005 tRNA binding surface [nucleotide binding]; other site 767455002006 anticodon binding site; other site 767455002007 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 767455002008 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 767455002009 DNA-binding site [nucleotide binding]; DNA binding site 767455002010 RNA-binding motif; other site 767455002011 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 767455002012 dimer interface [polypeptide binding]; other site 767455002013 ADP-ribose binding site [chemical binding]; other site 767455002014 active site 767455002015 nudix motif; other site 767455002016 metal binding site [ion binding]; metal-binding site 767455002017 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 767455002018 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 767455002019 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 767455002020 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 767455002021 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767455002022 catalytic residue [active] 767455002023 Putative amino acid metabolism; Region: DUF1831; pfam08866 767455002024 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 767455002025 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 767455002026 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767455002027 catalytic core [active] 767455002028 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767455002029 binding surface 767455002030 TPR motif; other site 767455002031 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 767455002032 binding surface 767455002033 TPR motif; other site 767455002034 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 767455002035 AAA domain; Region: AAA_30; pfam13604 767455002036 Family description; Region: UvrD_C_2; pfam13538 767455002037 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 767455002038 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767455002039 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 767455002040 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767455002041 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767455002042 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 767455002043 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 767455002044 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 767455002045 hypothetical protein; Provisional; Region: PRK13667 767455002046 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 767455002047 active site 767455002048 catalytic residues [active] 767455002049 metal binding site [ion binding]; metal-binding site 767455002050 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 767455002051 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 767455002052 G1 box; other site 767455002053 putative GEF interaction site [polypeptide binding]; other site 767455002054 GTP/Mg2+ binding site [chemical binding]; other site 767455002055 Switch I region; other site 767455002056 G2 box; other site 767455002057 G3 box; other site 767455002058 Switch II region; other site 767455002059 G4 box; other site 767455002060 G5 box; other site 767455002061 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 767455002062 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 767455002063 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 767455002064 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 767455002065 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 767455002066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767455002067 S-adenosylmethionine binding site [chemical binding]; other site 767455002068 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 767455002069 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 767455002070 active site 767455002071 (T/H)XGH motif; other site 767455002072 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 767455002073 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 767455002074 SLBB domain; Region: SLBB; pfam10531 767455002075 Helix-hairpin-helix motif; Region: HHH; pfam00633 767455002076 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 767455002077 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 767455002078 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 767455002079 Competence protein; Region: Competence; pfam03772 767455002080 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 767455002081 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 767455002082 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 767455002083 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 767455002084 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 767455002085 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 767455002086 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 767455002087 16S/18S rRNA binding site [nucleotide binding]; other site 767455002088 S13e-L30e interaction site [polypeptide binding]; other site 767455002089 25S rRNA binding site [nucleotide binding]; other site 767455002090 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 767455002091 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 767455002092 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 767455002093 elongation factor Tu; Reviewed; Region: PRK00049 767455002094 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 767455002095 G1 box; other site 767455002096 GEF interaction site [polypeptide binding]; other site 767455002097 GTP/Mg2+ binding site [chemical binding]; other site 767455002098 Switch I region; other site 767455002099 G2 box; other site 767455002100 G3 box; other site 767455002101 Switch II region; other site 767455002102 G4 box; other site 767455002103 G5 box; other site 767455002104 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 767455002105 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 767455002106 Antibiotic Binding Site [chemical binding]; other site 767455002107 trigger factor; Provisional; Region: tig; PRK01490 767455002108 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 767455002109 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 767455002110 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 767455002111 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 767455002112 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767455002113 Walker A motif; other site 767455002114 ATP binding site [chemical binding]; other site 767455002115 Walker B motif; other site 767455002116 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 767455002117 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 767455002118 G1 box; other site 767455002119 GTP/Mg2+ binding site [chemical binding]; other site 767455002120 Switch I region; other site 767455002121 G2 box; other site 767455002122 G3 box; other site 767455002123 Switch II region; other site 767455002124 G4 box; other site 767455002125 G5 box; other site 767455002126 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 767455002127 nucleophilic elbow; other site 767455002128 catalytic triad; other site 767455002129 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 767455002130 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 767455002131 FMN binding site [chemical binding]; other site 767455002132 dimer interface [polypeptide binding]; other site 767455002133 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 767455002134 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 767455002135 peptide binding site [polypeptide binding]; other site 767455002136 ABC transporter C family member; Provisional; Region: PLN03232 767455002137 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 767455002138 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cd04761 767455002139 DNA binding residues [nucleotide binding] 767455002140 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 767455002141 catalytic residues [active] 767455002142 catalytic nucleophile [active] 767455002143 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 767455002144 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 767455002145 homodimer interface [polypeptide binding]; other site 767455002146 ligand binding site [chemical binding]; other site 767455002147 NAD binding site [chemical binding]; other site 767455002148 catalytic site [active] 767455002149 thymidylate synthase; Region: thym_sym; TIGR03284 767455002150 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 767455002151 dimerization interface [polypeptide binding]; other site 767455002152 active site 767455002153 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 767455002154 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 767455002155 folate binding site [chemical binding]; other site 767455002156 NADP+ binding site [chemical binding]; other site 767455002157 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 767455002158 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767455002159 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767455002160 motif II; other site 767455002161 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 767455002162 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 767455002163 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 767455002164 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 767455002165 Walker A/P-loop; other site 767455002166 ATP binding site [chemical binding]; other site 767455002167 Q-loop/lid; other site 767455002168 ABC transporter signature motif; other site 767455002169 Walker B; other site 767455002170 D-loop; other site 767455002171 H-loop/switch region; other site 767455002172 NIL domain; Region: NIL; pfam09383 767455002173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767455002174 dimer interface [polypeptide binding]; other site 767455002175 conserved gate region; other site 767455002176 ABC-ATPase subunit interface; other site 767455002177 L-aspartate oxidase; Provisional; Region: PRK06175 767455002178 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 767455002179 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 767455002180 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 767455002181 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 767455002182 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767455002183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767455002184 homodimer interface [polypeptide binding]; other site 767455002185 catalytic residue [active] 767455002186 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767455002187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767455002188 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767455002189 dimerization interface [polypeptide binding]; other site 767455002190 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 767455002191 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 767455002192 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 767455002193 active site 767455002194 HIGH motif; other site 767455002195 KMSK motif region; other site 767455002196 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 767455002197 tRNA binding surface [nucleotide binding]; other site 767455002198 anticodon binding site; other site 767455002199 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 767455002200 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 767455002201 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 767455002202 Flavoprotein; Region: Flavoprotein; pfam02441 767455002203 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 767455002204 Amidohydrolase; Region: Amidohydro_2; pfam04909 767455002205 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 767455002206 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 767455002207 putative ligand binding site [chemical binding]; other site 767455002208 putative NAD binding site [chemical binding]; other site 767455002209 catalytic site [active] 767455002210 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 767455002211 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767455002212 ATP binding site [chemical binding]; other site 767455002213 putative Mg++ binding site [ion binding]; other site 767455002214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767455002215 nucleotide binding region [chemical binding]; other site 767455002216 ATP-binding site [chemical binding]; other site 767455002217 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 767455002218 HRDC domain; Region: HRDC; pfam00570 767455002219 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 767455002220 active site 767455002221 dimerization interface [polypeptide binding]; other site 767455002222 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 767455002223 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 767455002224 GIY-YIG motif/motif A; other site 767455002225 active site 767455002226 catalytic site [active] 767455002227 putative DNA binding site [nucleotide binding]; other site 767455002228 metal binding site [ion binding]; metal-binding site 767455002229 UvrB/uvrC motif; Region: UVR; pfam02151 767455002230 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 767455002231 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 767455002232 DNA binding site [nucleotide binding] 767455002233 GTPase CgtA; Reviewed; Region: obgE; PRK12297 767455002234 GTP1/OBG; Region: GTP1_OBG; pfam01018 767455002235 Obg GTPase; Region: Obg; cd01898 767455002236 G1 box; other site 767455002237 GTP/Mg2+ binding site [chemical binding]; other site 767455002238 Switch I region; other site 767455002239 G2 box; other site 767455002240 G3 box; other site 767455002241 Switch II region; other site 767455002242 G4 box; other site 767455002243 G5 box; other site 767455002244 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 767455002245 Acyltransferase family; Region: Acyl_transf_3; pfam01757 767455002246 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 767455002247 catalytic triad [active] 767455002248 catalytic triad [active] 767455002249 oxyanion hole [active] 767455002250 ribonuclease Z; Region: RNase_Z; TIGR02651 767455002251 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767455002252 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 767455002253 NAD(P) binding site [chemical binding]; other site 767455002254 active site 767455002255 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 767455002256 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 767455002257 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 767455002258 active site 767455002259 metal binding site [ion binding]; metal-binding site 767455002260 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 767455002261 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 767455002262 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767455002263 nucleotide binding region [chemical binding]; other site 767455002264 ATP-binding site [chemical binding]; other site 767455002265 hypothetical protein; Provisional; Region: PRK13690 767455002266 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 767455002267 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 767455002268 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 767455002269 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 767455002270 putative catalytic cysteine [active] 767455002271 gamma-glutamyl kinase; Provisional; Region: PRK05429 767455002272 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 767455002273 nucleotide binding site [chemical binding]; other site 767455002274 homotetrameric interface [polypeptide binding]; other site 767455002275 putative phosphate binding site [ion binding]; other site 767455002276 putative allosteric binding site; other site 767455002277 PUA domain; Region: PUA; pfam01472 767455002278 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 767455002279 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 767455002280 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 767455002281 active site 767455002282 PHP Thumb interface [polypeptide binding]; other site 767455002283 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 767455002284 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 767455002285 active site 767455002286 ADP/pyrophosphate binding site [chemical binding]; other site 767455002287 dimerization interface [polypeptide binding]; other site 767455002288 allosteric effector site; other site 767455002289 fructose-1,6-bisphosphate binding site; other site 767455002290 pyruvate kinase; Provisional; Region: PRK06354 767455002291 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 767455002292 domain interfaces; other site 767455002293 active site 767455002294 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 767455002295 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767455002296 Q-loop/lid; other site 767455002297 ABC transporter signature motif; other site 767455002298 Acyltransferase family; Region: Acyl_transf_3; pfam01757 767455002299 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 767455002300 S1 domain; Region: S1_2; pfam13509 767455002301 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 767455002302 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 767455002303 active site 767455002304 Int/Topo IB signature motif; other site 767455002305 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 767455002306 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 767455002307 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 767455002308 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767455002309 RNA binding surface [nucleotide binding]; other site 767455002310 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 767455002311 active site 767455002312 Predicted membrane protein [Function unknown]; Region: COG3601 767455002313 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 767455002314 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767455002315 cytidylate kinase; Provisional; Region: cmk; PRK00023 767455002316 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 767455002317 CMP-binding site; other site 767455002318 The sites determining sugar specificity; other site 767455002319 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 767455002320 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 767455002321 RNA binding site [nucleotide binding]; other site 767455002322 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 767455002323 RNA binding site [nucleotide binding]; other site 767455002324 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 767455002325 RNA binding site [nucleotide binding]; other site 767455002326 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 767455002327 RNA binding site [nucleotide binding]; other site 767455002328 GTP-binding protein Der; Reviewed; Region: PRK00093 767455002329 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 767455002330 G1 box; other site 767455002331 GTP/Mg2+ binding site [chemical binding]; other site 767455002332 Switch I region; other site 767455002333 G2 box; other site 767455002334 Switch II region; other site 767455002335 G3 box; other site 767455002336 G4 box; other site 767455002337 G5 box; other site 767455002338 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 767455002339 G1 box; other site 767455002340 GTP/Mg2+ binding site [chemical binding]; other site 767455002341 Switch I region; other site 767455002342 G2 box; other site 767455002343 G3 box; other site 767455002344 Switch II region; other site 767455002345 G4 box; other site 767455002346 G5 box; other site 767455002347 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 767455002348 IHF dimer interface [polypeptide binding]; other site 767455002349 IHF - DNA interface [nucleotide binding]; other site 767455002350 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767455002351 binding surface 767455002352 TPR motif; other site 767455002353 TPR repeat; Region: TPR_11; pfam13414 767455002354 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 767455002355 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767455002356 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767455002357 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767455002358 dimerization interface [polypeptide binding]; other site 767455002359 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767455002360 Integrase core domain; Region: rve; pfam00665 767455002361 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767455002362 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767455002363 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767455002364 dimerization interface [polypeptide binding]; other site 767455002365 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767455002366 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767455002367 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767455002368 dimerization interface [polypeptide binding]; other site 767455002369 argininosuccinate synthase; Provisional; Region: PRK13820 767455002370 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 767455002371 ANP binding site [chemical binding]; other site 767455002372 Substrate Binding Site II [chemical binding]; other site 767455002373 Substrate Binding Site I [chemical binding]; other site 767455002374 argininosuccinate lyase; Provisional; Region: PRK00855 767455002375 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 767455002376 active sites [active] 767455002377 tetramer interface [polypeptide binding]; other site 767455002378 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767455002379 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 767455002380 MULE transposase domain; Region: MULE; pfam10551 767455002381 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 767455002382 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767455002383 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 767455002384 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 767455002385 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 767455002386 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 767455002387 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 767455002388 helicase Cas3; Provisional; Region: PRK09694 767455002389 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 767455002390 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 767455002391 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 767455002392 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 767455002393 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 767455002394 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 767455002395 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 767455002396 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 767455002397 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 767455002398 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 767455002399 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 767455002400 active site 767455002401 catalytic site [active] 767455002402 substrate binding site [chemical binding]; other site 767455002403 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 767455002404 synthetase active site [active] 767455002405 metal binding site [ion binding]; metal-binding site 767455002406 NTP binding site [chemical binding]; other site 767455002407 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767455002408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767455002409 active site 767455002410 phosphorylation site [posttranslational modification] 767455002411 intermolecular recognition site; other site 767455002412 dimerization interface [polypeptide binding]; other site 767455002413 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767455002414 DNA binding site [nucleotide binding] 767455002415 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767455002416 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767455002417 dimer interface [polypeptide binding]; other site 767455002418 phosphorylation site [posttranslational modification] 767455002419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767455002420 ATP binding site [chemical binding]; other site 767455002421 Mg2+ binding site [ion binding]; other site 767455002422 G-X-G motif; other site 767455002423 putative acyltransferase; Provisional; Region: PRK05790 767455002424 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 767455002425 dimer interface [polypeptide binding]; other site 767455002426 active site 767455002427 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 767455002428 homodimer interface [polypeptide binding]; other site 767455002429 catalytic residues [active] 767455002430 NAD binding site [chemical binding]; other site 767455002431 substrate binding pocket [chemical binding]; other site 767455002432 flexible flap; other site 767455002433 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 767455002434 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 767455002435 dimer interface [polypeptide binding]; other site 767455002436 active site 767455002437 Uncharacterized conserved protein [Function unknown]; Region: COG2966 767455002438 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 767455002439 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 767455002440 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 767455002441 putative deacylase active site [active] 767455002442 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 767455002443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767455002444 S-adenosylmethionine binding site [chemical binding]; other site 767455002445 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 767455002446 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767455002447 Zn2+ binding site [ion binding]; other site 767455002448 Mg2+ binding site [ion binding]; other site 767455002449 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 767455002450 synthetase active site [active] 767455002451 NTP binding site [chemical binding]; other site 767455002452 metal binding site [ion binding]; metal-binding site 767455002453 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 767455002454 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 767455002455 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 767455002456 putative active site [active] 767455002457 dimerization interface [polypeptide binding]; other site 767455002458 putative tRNAtyr binding site [nucleotide binding]; other site 767455002459 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 767455002460 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 767455002461 dimer interface [polypeptide binding]; other site 767455002462 motif 1; other site 767455002463 active site 767455002464 motif 2; other site 767455002465 motif 3; other site 767455002466 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 767455002467 anticodon binding site; other site 767455002468 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 767455002469 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 767455002470 dimer interface [polypeptide binding]; other site 767455002471 anticodon binding site; other site 767455002472 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 767455002473 homodimer interface [polypeptide binding]; other site 767455002474 motif 1; other site 767455002475 active site 767455002476 motif 2; other site 767455002477 GAD domain; Region: GAD; pfam02938 767455002478 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 767455002479 active site 767455002480 motif 3; other site 767455002481 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 767455002482 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 767455002483 Domain of unknown function DUF20; Region: UPF0118; pfam01594 767455002484 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 767455002485 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 767455002486 dimer interface [polypeptide binding]; other site 767455002487 active site 767455002488 CoA binding pocket [chemical binding]; other site 767455002489 acyl carrier protein; Provisional; Region: acpP; PRK00982 767455002490 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 767455002491 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 767455002492 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 767455002493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767455002494 NAD(P) binding site [chemical binding]; other site 767455002495 active site 767455002496 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 767455002497 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 767455002498 dimer interface [polypeptide binding]; other site 767455002499 active site 767455002500 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 767455002501 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 767455002502 carboxyltransferase (CT) interaction site; other site 767455002503 biotinylation site [posttranslational modification]; other site 767455002504 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 767455002505 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 767455002506 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767455002507 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767455002508 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 767455002509 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 767455002510 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 767455002511 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 767455002512 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 767455002513 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 767455002514 NAD binding site [chemical binding]; other site 767455002515 homotetramer interface [polypeptide binding]; other site 767455002516 homodimer interface [polypeptide binding]; other site 767455002517 substrate binding site [chemical binding]; other site 767455002518 active site 767455002519 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 767455002520 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 767455002521 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 767455002522 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 767455002523 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 767455002524 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 767455002525 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 767455002526 putative catalytic cysteine [active] 767455002527 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 767455002528 putative active site [active] 767455002529 metal binding site [ion binding]; metal-binding site 767455002530 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 767455002531 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 767455002532 asparagine synthetase B; Provisional; Region: asnB; PRK09431 767455002533 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 767455002534 active site 767455002535 dimer interface [polypeptide binding]; other site 767455002536 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 767455002537 Ligand Binding Site [chemical binding]; other site 767455002538 Molecular Tunnel; other site 767455002539 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 767455002540 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 767455002541 peptide binding site [polypeptide binding]; other site 767455002542 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 767455002543 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 767455002544 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 767455002545 PBP superfamily domain; Region: PBP_like_2; cl17296 767455002546 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 767455002547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767455002548 dimer interface [polypeptide binding]; other site 767455002549 conserved gate region; other site 767455002550 putative PBP binding loops; other site 767455002551 ABC-ATPase subunit interface; other site 767455002552 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 767455002553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767455002554 dimer interface [polypeptide binding]; other site 767455002555 conserved gate region; other site 767455002556 putative PBP binding loops; other site 767455002557 ABC-ATPase subunit interface; other site 767455002558 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 767455002559 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 767455002560 Walker A/P-loop; other site 767455002561 ATP binding site [chemical binding]; other site 767455002562 Q-loop/lid; other site 767455002563 ABC transporter signature motif; other site 767455002564 Walker B; other site 767455002565 D-loop; other site 767455002566 H-loop/switch region; other site 767455002567 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 767455002568 PhoU domain; Region: PhoU; pfam01895 767455002569 PhoU domain; Region: PhoU; pfam01895 767455002570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767455002571 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767455002572 active site 767455002573 phosphorylation site [posttranslational modification] 767455002574 intermolecular recognition site; other site 767455002575 dimerization interface [polypeptide binding]; other site 767455002576 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767455002577 DNA binding site [nucleotide binding] 767455002578 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 767455002579 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767455002580 dimer interface [polypeptide binding]; other site 767455002581 phosphorylation site [posttranslational modification] 767455002582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767455002583 ATP binding site [chemical binding]; other site 767455002584 Mg2+ binding site [ion binding]; other site 767455002585 G-X-G motif; other site 767455002586 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 767455002587 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 767455002588 active site 767455002589 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 767455002590 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767455002591 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767455002592 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 767455002593 dimer interface [polypeptide binding]; other site 767455002594 ADP-ribose binding site [chemical binding]; other site 767455002595 active site 767455002596 nudix motif; other site 767455002597 metal binding site [ion binding]; metal-binding site 767455002598 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 767455002599 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 767455002600 nudix motif; other site 767455002601 Predicted membrane protein [Function unknown]; Region: COG1288 767455002602 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767455002603 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767455002604 Walker A/P-loop; other site 767455002605 ATP binding site [chemical binding]; other site 767455002606 Q-loop/lid; other site 767455002607 ABC transporter signature motif; other site 767455002608 Walker B; other site 767455002609 D-loop; other site 767455002610 H-loop/switch region; other site 767455002611 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767455002612 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767455002613 Walker A/P-loop; other site 767455002614 ATP binding site [chemical binding]; other site 767455002615 Q-loop/lid; other site 767455002616 ABC transporter signature motif; other site 767455002617 Walker B; other site 767455002618 D-loop; other site 767455002619 H-loop/switch region; other site 767455002620 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 767455002621 PAS fold; Region: PAS_3; pfam08447 767455002622 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 767455002623 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 767455002624 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767455002625 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767455002626 putative Zn2+ binding site [ion binding]; other site 767455002627 putative DNA binding site [nucleotide binding]; other site 767455002628 MarR family; Region: MarR_2; cl17246 767455002629 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767455002630 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767455002631 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767455002632 Transposase; Region: DEDD_Tnp_IS110; pfam01548 767455002633 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 767455002634 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 767455002635 Dihydroneopterin aldolase; Region: FolB; pfam02152 767455002636 active site 767455002637 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 767455002638 catalytic center binding site [active] 767455002639 ATP binding site [chemical binding]; other site 767455002640 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 767455002641 GTP cyclohydrolase I; Provisional; Region: PLN03044 767455002642 active site 767455002643 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 767455002644 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767455002645 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767455002646 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 767455002647 dihydropteroate synthase; Region: DHPS; TIGR01496 767455002648 substrate binding pocket [chemical binding]; other site 767455002649 dimer interface [polypeptide binding]; other site 767455002650 inhibitor binding site; inhibition site 767455002651 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 767455002652 nudix motif; other site 767455002653 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767455002654 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767455002655 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 767455002656 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 767455002657 DNA binding residues [nucleotide binding] 767455002658 putative dimer interface [polypeptide binding]; other site 767455002659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 767455002660 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 767455002661 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 767455002662 Walker A/P-loop; other site 767455002663 ATP binding site [chemical binding]; other site 767455002664 Q-loop/lid; other site 767455002665 ABC transporter signature motif; other site 767455002666 Walker B; other site 767455002667 D-loop; other site 767455002668 H-loop/switch region; other site 767455002669 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 767455002670 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767455002671 substrate binding pocket [chemical binding]; other site 767455002672 membrane-bound complex binding site; other site 767455002673 hinge residues; other site 767455002674 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 767455002675 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 767455002676 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 767455002677 Mg2+ binding site [ion binding]; other site 767455002678 G-X-G motif; other site 767455002679 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 767455002680 anchoring element; other site 767455002681 dimer interface [polypeptide binding]; other site 767455002682 ATP binding site [chemical binding]; other site 767455002683 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 767455002684 active site 767455002685 putative metal-binding site [ion binding]; other site 767455002686 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 767455002687 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 767455002688 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 767455002689 CAP-like domain; other site 767455002690 active site 767455002691 primary dimer interface [polypeptide binding]; other site 767455002692 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767455002693 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 767455002694 DHH family; Region: DHH; pfam01368 767455002695 DHHA2 domain; Region: DHHA2; pfam02833 767455002696 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 767455002697 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 767455002698 homotetramer interface [polypeptide binding]; other site 767455002699 FMN binding site [chemical binding]; other site 767455002700 homodimer contacts [polypeptide binding]; other site 767455002701 putative active site [active] 767455002702 putative substrate binding site [chemical binding]; other site 767455002703 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 767455002704 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 767455002705 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 767455002706 diphosphomevalonate decarboxylase; Region: PLN02407 767455002707 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 767455002708 mevalonate kinase; Region: mevalon_kin; TIGR00549 767455002709 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 767455002710 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 767455002711 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 767455002712 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 767455002713 DEAD/DEAH box helicase; Region: DEAD; pfam00270 767455002714 Family description; Region: UvrD_C_2; pfam13538 767455002715 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 767455002716 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 767455002717 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 767455002718 active site 767455002719 catalytic site [active] 767455002720 substrate binding site [chemical binding]; other site 767455002721 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 767455002722 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 767455002723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 767455002724 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 767455002725 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 767455002726 putative dimer interface [polypeptide binding]; other site 767455002727 putative anticodon binding site; other site 767455002728 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 767455002729 homodimer interface [polypeptide binding]; other site 767455002730 motif 1; other site 767455002731 motif 2; other site 767455002732 active site 767455002733 motif 3; other site 767455002734 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 767455002735 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 767455002736 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 767455002737 endonuclease III; Region: ENDO3c; smart00478 767455002738 minor groove reading motif; other site 767455002739 helix-hairpin-helix signature motif; other site 767455002740 substrate binding pocket [chemical binding]; other site 767455002741 active site 767455002742 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 767455002743 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767455002744 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 767455002745 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 767455002746 D-lactate dehydrogenase; Validated; Region: PRK08605 767455002747 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 767455002748 homodimer interface [polypeptide binding]; other site 767455002749 ligand binding site [chemical binding]; other site 767455002750 NAD binding site [chemical binding]; other site 767455002751 catalytic site [active] 767455002752 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 767455002753 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 767455002754 Transglycosylase; Region: Transgly; pfam00912 767455002755 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 767455002756 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 767455002757 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 767455002758 hypothetical protein; Provisional; Region: PRK13660 767455002759 DivIVA protein; Region: DivIVA; pfam05103 767455002760 DivIVA domain; Region: DivI1A_domain; TIGR03544 767455002761 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 767455002762 oligomer interface [polypeptide binding]; other site 767455002763 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 767455002764 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 767455002765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 767455002766 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 767455002767 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 767455002768 active site 767455002769 metal binding site [ion binding]; metal-binding site 767455002770 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 767455002771 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 767455002772 Potassium binding sites [ion binding]; other site 767455002773 Cesium cation binding sites [ion binding]; other site 767455002774 lipoprotein signal peptidase; Provisional; Region: PRK14797 767455002775 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 767455002776 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767455002777 RNA binding surface [nucleotide binding]; other site 767455002778 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 767455002779 active site 767455002780 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 767455002781 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 767455002782 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 767455002783 catalytic site [active] 767455002784 subunit interface [polypeptide binding]; other site 767455002785 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 767455002786 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767455002787 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767455002788 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 767455002789 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767455002790 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767455002791 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 767455002792 IMP binding site; other site 767455002793 dimer interface [polypeptide binding]; other site 767455002794 interdomain contacts; other site 767455002795 partial ornithine binding site; other site 767455002796 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 767455002797 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 767455002798 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 767455002799 Domain of unknown function (DUF814); Region: DUF814; pfam05670 767455002800 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767455002801 EDD domain protein, DegV family; Region: DegV; TIGR00762 767455002802 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 767455002803 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 767455002804 EamA-like transporter family; Region: EamA; pfam00892 767455002805 EamA-like transporter family; Region: EamA; pfam00892 767455002806 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767455002807 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 767455002808 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 767455002809 putative ligand binding site [chemical binding]; other site 767455002810 putative NAD binding site [chemical binding]; other site 767455002811 putative catalytic site [active] 767455002812 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 767455002813 L-serine binding site [chemical binding]; other site 767455002814 ACT domain interface; other site 767455002815 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 767455002816 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767455002817 catalytic residue [active] 767455002818 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767455002819 catalytic core [active] 767455002820 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 767455002821 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 767455002822 FMN binding site [chemical binding]; other site 767455002823 dimer interface [polypeptide binding]; other site 767455002824 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 767455002825 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 767455002826 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 767455002827 dihydroorotase; Validated; Region: pyrC; PRK09357 767455002828 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 767455002829 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 767455002830 active site 767455002831 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 767455002832 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 767455002833 Walker A/P-loop; other site 767455002834 ATP binding site [chemical binding]; other site 767455002835 Q-loop/lid; other site 767455002836 ABC transporter signature motif; other site 767455002837 Walker B; other site 767455002838 D-loop; other site 767455002839 H-loop/switch region; other site 767455002840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767455002841 dimer interface [polypeptide binding]; other site 767455002842 conserved gate region; other site 767455002843 putative PBP binding loops; other site 767455002844 ABC-ATPase subunit interface; other site 767455002845 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 767455002846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767455002847 dimer interface [polypeptide binding]; other site 767455002848 conserved gate region; other site 767455002849 ABC-ATPase subunit interface; other site 767455002850 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 767455002851 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 767455002852 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 767455002853 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 767455002854 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 767455002855 Integrase core domain; Region: rve_2; pfam13333 767455002856 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 767455002857 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 767455002858 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 767455002859 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 767455002860 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 767455002861 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 767455002862 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 767455002863 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767455002864 HTH-like domain; Region: HTH_21; pfam13276 767455002865 Integrase core domain; Region: rve; pfam00665 767455002866 Integrase core domain; Region: rve_3; cl15866 767455002867 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767455002868 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767455002869 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767455002870 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 767455002871 MULE transposase domain; Region: MULE; pfam10551 767455002872 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 767455002873 DNA-binding interface [nucleotide binding]; DNA binding site 767455002874 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 767455002875 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 767455002876 P-loop; other site 767455002877 Magnesium ion binding site [ion binding]; other site 767455002878 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 767455002879 Magnesium ion binding site [ion binding]; other site 767455002880 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 767455002881 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767455002882 active site 767455002883 DNA binding site [nucleotide binding] 767455002884 Int/Topo IB signature motif; other site 767455002885 glycerate kinase; Region: TIGR00045 767455002886 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 767455002887 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 767455002888 Sel1-like repeats; Region: SEL1; smart00671 767455002889 Probable transposase; Region: OrfB_IS605; pfam01385 767455002890 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767455002891 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767455002892 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 767455002893 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 767455002894 active site 767455002895 I-site; other site 767455002896 metal binding site [ion binding]; metal-binding site 767455002897 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 767455002898 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 767455002899 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 767455002900 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 767455002901 peptide binding site [polypeptide binding]; other site 767455002902 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 767455002903 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 767455002904 peptide binding site [polypeptide binding]; other site 767455002905 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 767455002906 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 767455002907 Amidohydrolase; Region: Amidohydro_4; pfam13147 767455002908 active site 767455002909 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 767455002910 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 767455002911 catalytic Zn binding site [ion binding]; other site 767455002912 NAD(P) binding site [chemical binding]; other site 767455002913 structural Zn binding site [ion binding]; other site 767455002914 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 767455002915 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 767455002916 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 767455002917 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767455002918 ATP binding site [chemical binding]; other site 767455002919 putative Mg++ binding site [ion binding]; other site 767455002920 HsdM N-terminal domain; Region: HsdM_N; pfam12161 767455002921 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 767455002922 Methyltransferase domain; Region: Methyltransf_26; pfam13659 767455002923 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 767455002924 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 767455002925 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 767455002926 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 767455002927 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 767455002928 Homeodomain leucine-zipper encoding, Homez; Region: Homez; pfam11569 767455002929 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 767455002930 Int/Topo IB signature motif; other site 767455002931 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 767455002932 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 767455002933 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 767455002934 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767455002935 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767455002936 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767455002937 dimerization interface [polypeptide binding]; other site 767455002938 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 767455002939 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767455002940 motif II; other site 767455002941 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767455002942 Coenzyme A binding pocket [chemical binding]; other site 767455002943 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 767455002944 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 767455002945 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 767455002946 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 767455002947 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767455002948 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767455002949 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767455002950 dimerization interface [polypeptide binding]; other site 767455002951 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 767455002952 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 767455002953 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 767455002954 active site residue [active] 767455002955 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767455002956 putative transposase OrfB; Reviewed; Region: PHA02517 767455002957 HTH-like domain; Region: HTH_21; pfam13276 767455002958 Integrase core domain; Region: rve; pfam00665 767455002959 Integrase core domain; Region: rve_2; pfam13333 767455002960 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767455002961 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767455002962 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 767455002963 Walker A/P-loop; other site 767455002964 ATP binding site [chemical binding]; other site 767455002965 Q-loop/lid; other site 767455002966 ABC transporter signature motif; other site 767455002967 Walker B; other site 767455002968 D-loop; other site 767455002969 H-loop/switch region; other site 767455002970 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767455002971 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767455002972 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767455002973 Walker A/P-loop; other site 767455002974 ATP binding site [chemical binding]; other site 767455002975 Q-loop/lid; other site 767455002976 ABC transporter signature motif; other site 767455002977 Walker B; other site 767455002978 D-loop; other site 767455002979 H-loop/switch region; other site 767455002980 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 767455002981 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 767455002982 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_1; cd12161 767455002983 putative ligand binding site [chemical binding]; other site 767455002984 putative NAD binding site [chemical binding]; other site 767455002985 catalytic site [active] 767455002986 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767455002987 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767455002988 H-loop/switch region; other site 767455002989 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 767455002990 NADH(P)-binding; Region: NAD_binding_10; pfam13460 767455002991 NAD(P) binding site [chemical binding]; other site 767455002992 putative active site [active] 767455002993 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767455002994 dimerization interface [polypeptide binding]; other site 767455002995 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767455002996 catalytic core [active] 767455002997 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 767455002998 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 767455002999 TAP-like protein; Region: Abhydrolase_4; pfam08386 767455003000 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 767455003001 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 767455003002 peptide binding site [polypeptide binding]; other site 767455003003 Pathogenicity factor; Region: AvrE; pfam11725 767455003004 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 767455003005 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767455003006 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 767455003007 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 767455003008 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767455003009 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767455003010 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 767455003011 IMP binding site; other site 767455003012 dimer interface [polypeptide binding]; other site 767455003013 interdomain contacts; other site 767455003014 partial ornithine binding site; other site 767455003015 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 767455003016 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 767455003017 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 767455003018 catalytic site [active] 767455003019 subunit interface [polypeptide binding]; other site 767455003020 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 767455003021 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 767455003022 active site 767455003023 metal binding site [ion binding]; metal-binding site 767455003024 I-site; other site 767455003025 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 767455003026 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 767455003027 DNA binding residues [nucleotide binding] 767455003028 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 767455003029 dimer interface [polypeptide binding]; other site 767455003030 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767455003031 active site 767455003032 DNA binding site [nucleotide binding] 767455003033 Int/Topo IB signature motif; other site 767455003034 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 767455003035 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767455003036 Coenzyme A binding pocket [chemical binding]; other site 767455003037 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 767455003038 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767455003039 Walker A/P-loop; other site 767455003040 ATP binding site [chemical binding]; other site 767455003041 Q-loop/lid; other site 767455003042 ABC transporter signature motif; other site 767455003043 Walker B; other site 767455003044 D-loop; other site 767455003045 H-loop/switch region; other site 767455003046 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 767455003047 Low molecular weight phosphatase family; Region: LMWPc; cd00115 767455003048 active site 767455003049 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767455003050 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767455003051 Walker A/P-loop; other site 767455003052 ATP binding site [chemical binding]; other site 767455003053 Q-loop/lid; other site 767455003054 ABC transporter signature motif; other site 767455003055 Walker B; other site 767455003056 D-loop; other site 767455003057 H-loop/switch region; other site 767455003058 lipid kinase; Reviewed; Region: PRK13054 767455003059 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 767455003060 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 767455003061 Bacterial surface layer protein; Region: SLAP; pfam03217 767455003062 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 767455003063 active site 767455003064 aromatic amino acid aminotransferase; Validated; Region: PRK07309 767455003065 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767455003066 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767455003067 homodimer interface [polypeptide binding]; other site 767455003068 catalytic residue [active] 767455003069 dihydrodipicolinate reductase; Provisional; Region: PRK00048 767455003070 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 767455003071 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 767455003072 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 767455003073 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 767455003074 dimer interface [polypeptide binding]; other site 767455003075 active site 767455003076 catalytic residue [active] 767455003077 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 767455003078 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 767455003079 metal binding site [ion binding]; metal-binding site 767455003080 putative dimer interface [polypeptide binding]; other site 767455003081 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 767455003082 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 767455003083 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 767455003084 active site 767455003085 trimer interface [polypeptide binding]; other site 767455003086 substrate binding site [chemical binding]; other site 767455003087 CoA binding site [chemical binding]; other site 767455003088 aspartate kinase; Reviewed; Region: PRK09034 767455003089 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 767455003090 putative catalytic residues [active] 767455003091 putative nucleotide binding site [chemical binding]; other site 767455003092 putative aspartate binding site [chemical binding]; other site 767455003093 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 767455003094 allosteric regulatory residue; other site 767455003095 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 767455003096 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 767455003097 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 767455003098 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 767455003099 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 767455003100 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 767455003101 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767455003102 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767455003103 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 767455003104 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767455003105 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 767455003106 LytTr DNA-binding domain; Region: LytTR; smart00850 767455003107 Protein of unknown function (DUF419); Region: DUF419; pfam04237 767455003108 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 767455003109 putative active site [active] 767455003110 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 767455003111 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767455003112 Coenzyme A binding pocket [chemical binding]; other site 767455003113 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 767455003114 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 767455003115 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 767455003116 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 767455003117 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 767455003118 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 767455003119 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 767455003120 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 767455003121 DEAD-like helicases superfamily; Region: DEXDc; smart00487 767455003122 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767455003123 ATP binding site [chemical binding]; other site 767455003124 putative Mg++ binding site [ion binding]; other site 767455003125 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 767455003126 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 767455003127 putative dimer interface [polypeptide binding]; other site 767455003128 catalytic triad [active] 767455003129 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 767455003130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767455003131 S-adenosylmethionine binding site [chemical binding]; other site 767455003132 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 767455003133 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 767455003134 putative substrate binding pocket [chemical binding]; other site 767455003135 AC domain interface; other site 767455003136 catalytic triad [active] 767455003137 AB domain interface; other site 767455003138 interchain disulfide; other site 767455003139 Protease prsW family; Region: PrsW-protease; pfam13367 767455003140 Homoserine O-succinyltransferase; Region: HTS; pfam04204 767455003141 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 767455003142 proposed active site lysine [active] 767455003143 conserved cys residue [active] 767455003144 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 767455003145 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 767455003146 tetrameric interface [polypeptide binding]; other site 767455003147 activator binding site; other site 767455003148 NADP binding site [chemical binding]; other site 767455003149 substrate binding site [chemical binding]; other site 767455003150 catalytic residues [active] 767455003151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767455003152 dimer interface [polypeptide binding]; other site 767455003153 conserved gate region; other site 767455003154 putative PBP binding loops; other site 767455003155 ABC-ATPase subunit interface; other site 767455003156 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 767455003157 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 767455003158 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 767455003159 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767455003160 Walker A/P-loop; other site 767455003161 ATP binding site [chemical binding]; other site 767455003162 Q-loop/lid; other site 767455003163 ABC transporter signature motif; other site 767455003164 Walker B; other site 767455003165 D-loop; other site 767455003166 H-loop/switch region; other site 767455003167 Predicted transcriptional regulator [Transcription]; Region: COG1959 767455003168 Transcriptional regulator; Region: Rrf2; pfam02082 767455003169 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767455003170 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767455003171 Peptidase family M48; Region: Peptidase_M48; cl12018 767455003172 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 767455003173 putative active site [active] 767455003174 catalytic triad [active] 767455003175 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 767455003176 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 767455003177 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 767455003178 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 767455003179 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 767455003180 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767455003181 Coenzyme A binding pocket [chemical binding]; other site 767455003182 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 767455003183 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 767455003184 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 767455003185 dimer interface [polypeptide binding]; other site 767455003186 active site 767455003187 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 767455003188 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 767455003189 putative dimer interface [polypeptide binding]; other site 767455003190 putative anticodon binding site; other site 767455003191 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 767455003192 homodimer interface [polypeptide binding]; other site 767455003193 motif 1; other site 767455003194 motif 2; other site 767455003195 active site 767455003196 motif 3; other site 767455003197 Transcriptional regulators [Transcription]; Region: PurR; COG1609 767455003198 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767455003199 DNA binding site [nucleotide binding] 767455003200 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 767455003201 putative ligand binding site [chemical binding]; other site 767455003202 putative dimerization interface [polypeptide binding]; other site 767455003203 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 767455003204 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 767455003205 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 767455003206 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 767455003207 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 767455003208 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 767455003209 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 767455003210 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 767455003211 HPr interaction site; other site 767455003212 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767455003213 active site 767455003214 phosphorylation site [posttranslational modification] 767455003215 maltose O-acetyltransferase; Provisional; Region: PRK10092 767455003216 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 767455003217 active site 767455003218 substrate binding site [chemical binding]; other site 767455003219 trimer interface [polypeptide binding]; other site 767455003220 CoA binding site [chemical binding]; other site 767455003221 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767455003222 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 767455003223 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 767455003224 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 767455003225 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 767455003226 DNA binding residues [nucleotide binding] 767455003227 putative dimer interface [polypeptide binding]; other site 767455003228 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 767455003229 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 767455003230 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 767455003231 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 767455003232 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767455003233 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 767455003234 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767455003235 motif II; other site 767455003236 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 767455003237 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 767455003238 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 767455003239 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 767455003240 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 767455003241 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 767455003242 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 767455003243 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 767455003244 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 767455003245 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 767455003246 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 767455003247 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 767455003248 catalytic Zn binding site [ion binding]; other site 767455003249 NAD(P) binding site [chemical binding]; other site 767455003250 structural Zn binding site [ion binding]; other site 767455003251 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 767455003252 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 767455003253 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 767455003254 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 767455003255 Catalytic site [active] 767455003256 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 767455003257 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 767455003258 Catalytic site [active] 767455003259 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 767455003260 peptidase T; Region: peptidase-T; TIGR01882 767455003261 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 767455003262 metal binding site [ion binding]; metal-binding site 767455003263 dimer interface [polypeptide binding]; other site 767455003264 Uncharacterized conserved protein [Function unknown]; Region: COG0327 767455003265 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 767455003266 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 767455003267 Family of unknown function (DUF633); Region: DUF633; pfam04816 767455003268 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 767455003269 putative active site [active] 767455003270 nucleotide binding site [chemical binding]; other site 767455003271 nudix motif; other site 767455003272 putative metal binding site [ion binding]; other site 767455003273 Peptidase family M23; Region: Peptidase_M23; pfam01551 767455003274 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767455003275 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 767455003276 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 767455003277 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 767455003278 catalytic residues [active] 767455003279 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 767455003280 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 767455003281 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 767455003282 DNA binding site [nucleotide binding] 767455003283 active site 767455003284 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 767455003285 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 767455003286 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 767455003287 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 767455003288 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 767455003289 AAA domain; Region: AAA_11; pfam13086 767455003290 Part of AAA domain; Region: AAA_19; pfam13245 767455003291 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 767455003292 AAA domain; Region: AAA_12; pfam13087 767455003293 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 767455003294 putative active site [active] 767455003295 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 767455003296 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 767455003297 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 767455003298 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767455003299 Helix-turn-helix domain; Region: HTH_38; pfam13936 767455003300 Integrase core domain; Region: rve; pfam00665 767455003301 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 767455003302 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 767455003303 substrate binding pocket [chemical binding]; other site 767455003304 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 767455003305 putative active site [active] 767455003306 heme pocket [chemical binding]; other site 767455003307 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 767455003308 Melibiase; Region: Melibiase; pfam02065 767455003309 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 767455003310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767455003311 putative substrate translocation pore; other site 767455003312 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 767455003313 HPr interaction site; other site 767455003314 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767455003315 active site 767455003316 phosphorylation site [posttranslational modification] 767455003317 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 767455003318 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 767455003319 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767455003320 hypothetical protein; Provisional; Region: PRK00967 767455003321 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 767455003322 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 767455003323 active site 767455003324 P-loop; other site 767455003325 phosphorylation site [posttranslational modification] 767455003326 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 767455003327 beta-galactosidase; Region: BGL; TIGR03356 767455003328 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 767455003329 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 767455003330 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767455003331 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 767455003332 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767455003333 DNA binding residues [nucleotide binding] 767455003334 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 767455003335 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 767455003336 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767455003337 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 767455003338 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767455003339 DNA binding residues [nucleotide binding] 767455003340 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 767455003341 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 767455003342 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767455003343 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 767455003344 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767455003345 DNA binding residues [nucleotide binding] 767455003346 DNA primase; Validated; Region: dnaG; PRK05667 767455003347 CHC2 zinc finger; Region: zf-CHC2; pfam01807 767455003348 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 767455003349 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 767455003350 active site 767455003351 metal binding site [ion binding]; metal-binding site 767455003352 interdomain interaction site; other site 767455003353 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 767455003354 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 767455003355 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 767455003356 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 767455003357 motif 1; other site 767455003358 dimer interface [polypeptide binding]; other site 767455003359 active site 767455003360 motif 2; other site 767455003361 motif 3; other site 767455003362 DNA repair protein RecO; Region: reco; TIGR00613 767455003363 Recombination protein O N terminal; Region: RecO_N; pfam11967 767455003364 Recombination protein O C terminal; Region: RecO_C; pfam02565 767455003365 GTPase Era; Reviewed; Region: era; PRK00089 767455003366 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 767455003367 G1 box; other site 767455003368 GTP/Mg2+ binding site [chemical binding]; other site 767455003369 Switch I region; other site 767455003370 G2 box; other site 767455003371 Switch II region; other site 767455003372 G3 box; other site 767455003373 G4 box; other site 767455003374 G5 box; other site 767455003375 KH domain; Region: KH_2; pfam07650 767455003376 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 767455003377 active site 767455003378 catalytic motif [active] 767455003379 Zn binding site [ion binding]; other site 767455003380 metal-binding heat shock protein; Provisional; Region: PRK00016 767455003381 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 767455003382 PhoH-like protein; Region: PhoH; pfam02562 767455003383 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 767455003384 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 767455003385 Uncharacterized conserved protein [Function unknown]; Region: COG1284 767455003386 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 767455003387 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 767455003388 aromatic amino acid aminotransferase; Validated; Region: PRK07309 767455003389 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767455003390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767455003391 homodimer interface [polypeptide binding]; other site 767455003392 catalytic residue [active] 767455003393 diaminopimelate decarboxylase; Region: lysA; TIGR01048 767455003394 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 767455003395 active site 767455003396 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 767455003397 substrate binding site [chemical binding]; other site 767455003398 catalytic residues [active] 767455003399 dimer interface [polypeptide binding]; other site 767455003400 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 767455003401 active site 767455003402 catalytic residues [active] 767455003403 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 767455003404 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767455003405 Walker A motif; other site 767455003406 ATP binding site [chemical binding]; other site 767455003407 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767455003408 Walker B motif; other site 767455003409 arginine finger; other site 767455003410 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 767455003411 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 767455003412 active site 767455003413 HslU subunit interaction site [polypeptide binding]; other site 767455003414 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 767455003415 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767455003416 active site 767455003417 DNA binding site [nucleotide binding] 767455003418 Int/Topo IB signature motif; other site 767455003419 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 767455003420 Glucose inhibited division protein A; Region: GIDA; pfam01134 767455003421 DNA topoisomerase I; Validated; Region: PRK05582 767455003422 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 767455003423 active site 767455003424 interdomain interaction site; other site 767455003425 putative metal-binding site [ion binding]; other site 767455003426 nucleotide binding site [chemical binding]; other site 767455003427 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 767455003428 domain I; other site 767455003429 DNA binding groove [nucleotide binding] 767455003430 phosphate binding site [ion binding]; other site 767455003431 domain II; other site 767455003432 domain III; other site 767455003433 nucleotide binding site [chemical binding]; other site 767455003434 catalytic site [active] 767455003435 domain IV; other site 767455003436 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 767455003437 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 767455003438 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 767455003439 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 767455003440 DNA binding residues [nucleotide binding] 767455003441 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 767455003442 catalytic residues [active] 767455003443 catalytic nucleophile [active] 767455003444 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767455003445 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 767455003446 DNA protecting protein DprA; Region: dprA; TIGR00732 767455003447 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 767455003448 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 767455003449 RNA/DNA hybrid binding site [nucleotide binding]; other site 767455003450 active site 767455003451 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 767455003452 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 767455003453 GTP/Mg2+ binding site [chemical binding]; other site 767455003454 G4 box; other site 767455003455 G5 box; other site 767455003456 G1 box; other site 767455003457 Switch I region; other site 767455003458 G2 box; other site 767455003459 G3 box; other site 767455003460 Switch II region; other site 767455003461 hypothetical protein; Provisional; Region: PRK13672 767455003462 EDD domain protein, DegV family; Region: DegV; TIGR00762 767455003463 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 767455003464 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 767455003465 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 767455003466 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 767455003467 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 767455003468 active site 767455003469 NTP binding site [chemical binding]; other site 767455003470 metal binding triad [ion binding]; metal-binding site 767455003471 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 767455003472 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 767455003473 Uncharacterized conserved protein [Function unknown]; Region: COG1284 767455003474 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 767455003475 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 767455003476 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 767455003477 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767455003478 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767455003479 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 767455003480 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 767455003481 DNA binding residues [nucleotide binding] 767455003482 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 767455003483 catalytic residues [active] 767455003484 catalytic nucleophile [active] 767455003485 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 767455003486 nucleotidyl binding site; other site 767455003487 metal binding site [ion binding]; metal-binding site 767455003488 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767455003489 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767455003490 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767455003491 Walker A/P-loop; other site 767455003492 ATP binding site [chemical binding]; other site 767455003493 Q-loop/lid; other site 767455003494 ABC transporter signature motif; other site 767455003495 Walker B; other site 767455003496 D-loop; other site 767455003497 H-loop/switch region; other site 767455003498 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767455003499 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767455003500 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767455003501 Walker A/P-loop; other site 767455003502 ATP binding site [chemical binding]; other site 767455003503 Q-loop/lid; other site 767455003504 ABC transporter signature motif; other site 767455003505 Walker B; other site 767455003506 D-loop; other site 767455003507 H-loop/switch region; other site 767455003508 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767455003509 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767455003510 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767455003511 dimerization interface [polypeptide binding]; other site 767455003512 Short C-terminal domain; Region: SHOCT; pfam09851 767455003513 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 767455003514 active site 767455003515 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 767455003516 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 767455003517 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767455003518 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 767455003519 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 767455003520 Phage tail protein; Region: Sipho_tail; cl17486 767455003521 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 767455003522 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 767455003523 Phage major tail protein; Region: Phage_tail; pfam04630 767455003524 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 767455003525 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 767455003526 oligomerization interface [polypeptide binding]; other site 767455003527 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 767455003528 Phage capsid family; Region: Phage_capsid; pfam05065 767455003529 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 767455003530 oligomer interface [polypeptide binding]; other site 767455003531 Clp protease; Region: CLP_protease; pfam00574 767455003532 active site residues [active] 767455003533 Phage-related protein [Function unknown]; Region: COG4695 767455003534 Phage portal protein; Region: Phage_portal; pfam04860 767455003535 Phage terminase, small subunit; Region: Terminase_4; pfam05119 767455003536 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 767455003537 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 767455003538 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 767455003539 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 767455003540 Rad4 beta-hairpin domain 2; Region: BHD_2; cl11063 767455003541 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 767455003542 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 767455003543 cofactor binding site; other site 767455003544 DNA binding site [nucleotide binding] 767455003545 substrate interaction site [chemical binding]; other site 767455003546 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 767455003547 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767455003548 Probable transposase; Region: OrfB_IS605; pfam01385 767455003549 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767455003550 Homeodomain-like domain; Region: HTH_23; cl17451 767455003551 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 767455003552 VRR-NUC domain; Region: VRR_NUC; pfam08774 767455003553 Uncharacterized conserved protein [Function unknown]; Region: COG4983 767455003554 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 767455003555 nucleotide binding site [chemical binding]; other site 767455003556 D5 N terminal like; Region: D5_N; pfam08706 767455003557 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 767455003558 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 767455003559 Protein of unknown function (DUF669); Region: DUF669; pfam05037 767455003560 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 767455003561 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767455003562 ATP binding site [chemical binding]; other site 767455003563 putative Mg++ binding site [ion binding]; other site 767455003564 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767455003565 nucleotide binding region [chemical binding]; other site 767455003566 ATP-binding site [chemical binding]; other site 767455003567 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 767455003568 AAA domain; Region: AAA_24; pfam13479 767455003569 Prophage antirepressor [Transcription]; Region: COG3617 767455003570 BRO family, N-terminal domain; Region: Bro-N; smart01040 767455003571 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 767455003572 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767455003573 non-specific DNA binding site [nucleotide binding]; other site 767455003574 salt bridge; other site 767455003575 sequence-specific DNA binding site [nucleotide binding]; other site 767455003576 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767455003577 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767455003578 non-specific DNA binding site [nucleotide binding]; other site 767455003579 salt bridge; other site 767455003580 sequence-specific DNA binding site [nucleotide binding]; other site 767455003581 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 767455003582 Catalytic site [active] 767455003583 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 767455003584 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767455003585 active site 767455003586 DNA binding site [nucleotide binding] 767455003587 Int/Topo IB signature motif; other site 767455003588 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 767455003589 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 767455003590 active site 767455003591 EDD domain protein, DegV family; Region: DegV; TIGR00762 767455003592 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 767455003593 enolase; Provisional; Region: eno; PRK00077 767455003594 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 767455003595 dimer interface [polypeptide binding]; other site 767455003596 metal binding site [ion binding]; metal-binding site 767455003597 substrate binding pocket [chemical binding]; other site 767455003598 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 767455003599 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 767455003600 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 767455003601 Walker A/P-loop; other site 767455003602 ATP binding site [chemical binding]; other site 767455003603 Q-loop/lid; other site 767455003604 ABC transporter signature motif; other site 767455003605 Walker B; other site 767455003606 D-loop; other site 767455003607 H-loop/switch region; other site 767455003608 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767455003609 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767455003610 substrate binding pocket [chemical binding]; other site 767455003611 membrane-bound complex binding site; other site 767455003612 hinge residues; other site 767455003613 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 767455003614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767455003615 dimer interface [polypeptide binding]; other site 767455003616 conserved gate region; other site 767455003617 putative PBP binding loops; other site 767455003618 ABC-ATPase subunit interface; other site 767455003619 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767455003620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767455003621 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767455003622 dimerization interface [polypeptide binding]; other site 767455003623 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 767455003624 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 767455003625 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767455003626 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767455003627 motif I; other site 767455003628 motif II; other site 767455003629 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 767455003630 Domain of unknown function DUF20; Region: UPF0118; pfam01594 767455003631 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 767455003632 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 767455003633 homodimer interface [polypeptide binding]; other site 767455003634 substrate-cofactor binding pocket; other site 767455003635 catalytic residue [active] 767455003636 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 767455003637 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 767455003638 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767455003639 dimerization interface [polypeptide binding]; other site 767455003640 putative DNA binding site [nucleotide binding]; other site 767455003641 putative Zn2+ binding site [ion binding]; other site 767455003642 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767455003643 active site 767455003644 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 767455003645 DHH family; Region: DHH; pfam01368 767455003646 DHHA1 domain; Region: DHHA1; pfam02272 767455003647 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 767455003648 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 767455003649 active site 767455003650 catalytic site [active] 767455003651 GTP-binding protein LepA; Provisional; Region: PRK05433 767455003652 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 767455003653 G1 box; other site 767455003654 putative GEF interaction site [polypeptide binding]; other site 767455003655 GTP/Mg2+ binding site [chemical binding]; other site 767455003656 Switch I region; other site 767455003657 G2 box; other site 767455003658 G3 box; other site 767455003659 Switch II region; other site 767455003660 G4 box; other site 767455003661 G5 box; other site 767455003662 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 767455003663 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 767455003664 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 767455003665 chaperone protein DnaJ; Provisional; Region: PRK14276 767455003666 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 767455003667 HSP70 interaction site [polypeptide binding]; other site 767455003668 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 767455003669 substrate binding site [polypeptide binding]; other site 767455003670 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 767455003671 Zn binding sites [ion binding]; other site 767455003672 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 767455003673 dimer interface [polypeptide binding]; other site 767455003674 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 767455003675 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 767455003676 nucleotide binding site [chemical binding]; other site 767455003677 NEF interaction site [polypeptide binding]; other site 767455003678 SBD interface [polypeptide binding]; other site 767455003679 GrpE; Region: GrpE; pfam01025 767455003680 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 767455003681 dimer interface [polypeptide binding]; other site 767455003682 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 767455003683 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 767455003684 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 767455003685 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 767455003686 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 767455003687 active site 767455003688 Riboflavin kinase; Region: Flavokinase; smart00904 767455003689 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767455003690 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 767455003691 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767455003692 MULE transposase domain; Region: MULE; pfam10551 767455003693 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767455003694 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767455003695 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 767455003696 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 767455003697 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 767455003698 dimer interface [polypeptide binding]; other site 767455003699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767455003700 catalytic residue [active] 767455003701 cystathionine beta-lyase; Provisional; Region: PRK07671 767455003702 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 767455003703 homodimer interface [polypeptide binding]; other site 767455003704 substrate-cofactor binding pocket; other site 767455003705 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767455003706 catalytic residue [active] 767455003707 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 767455003708 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 767455003709 RNA binding site [nucleotide binding]; other site 767455003710 active site 767455003711 ribosome-binding factor A; Provisional; Region: PRK13818 767455003712 translation initiation factor IF-2; Validated; Region: infB; PRK05306 767455003713 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 767455003714 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 767455003715 G1 box; other site 767455003716 putative GEF interaction site [polypeptide binding]; other site 767455003717 GTP/Mg2+ binding site [chemical binding]; other site 767455003718 Switch I region; other site 767455003719 G2 box; other site 767455003720 G3 box; other site 767455003721 Switch II region; other site 767455003722 G4 box; other site 767455003723 G5 box; other site 767455003724 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 767455003725 Translation-initiation factor 2; Region: IF-2; pfam11987 767455003726 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 767455003727 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 767455003728 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 767455003729 putative RNA binding cleft [nucleotide binding]; other site 767455003730 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 767455003731 NusA N-terminal domain; Region: NusA_N; pfam08529 767455003732 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 767455003733 RNA binding site [nucleotide binding]; other site 767455003734 homodimer interface [polypeptide binding]; other site 767455003735 NusA-like KH domain; Region: KH_5; pfam13184 767455003736 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 767455003737 G-X-X-G motif; other site 767455003738 ribosome maturation protein RimP; Reviewed; Region: PRK00092 767455003739 Sm and related proteins; Region: Sm_like; cl00259 767455003740 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 767455003741 putative oligomer interface [polypeptide binding]; other site 767455003742 putative RNA binding site [nucleotide binding]; other site 767455003743 DNA polymerase III PolC; Validated; Region: polC; PRK00448 767455003744 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 767455003745 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 767455003746 generic binding surface II; other site 767455003747 generic binding surface I; other site 767455003748 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 767455003749 active site 767455003750 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 767455003751 active site 767455003752 catalytic site [active] 767455003753 substrate binding site [chemical binding]; other site 767455003754 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 767455003755 prolyl-tRNA synthetase; Provisional; Region: PRK09194 767455003756 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 767455003757 dimer interface [polypeptide binding]; other site 767455003758 motif 1; other site 767455003759 active site 767455003760 motif 2; other site 767455003761 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 767455003762 putative deacylase active site [active] 767455003763 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 767455003764 active site 767455003765 motif 3; other site 767455003766 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 767455003767 anticodon binding site; other site 767455003768 RIP metalloprotease RseP; Region: TIGR00054 767455003769 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 767455003770 active site 767455003771 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 767455003772 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 767455003773 protein binding site [polypeptide binding]; other site 767455003774 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 767455003775 putative substrate binding region [chemical binding]; other site 767455003776 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 767455003777 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 767455003778 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 767455003779 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 767455003780 catalytic residue [active] 767455003781 putative FPP diphosphate binding site; other site 767455003782 putative FPP binding hydrophobic cleft; other site 767455003783 dimer interface [polypeptide binding]; other site 767455003784 putative IPP diphosphate binding site; other site 767455003785 ribosome recycling factor; Reviewed; Region: frr; PRK00083 767455003786 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 767455003787 hinge region; other site 767455003788 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 767455003789 putative nucleotide binding site [chemical binding]; other site 767455003790 uridine monophosphate binding site [chemical binding]; other site 767455003791 homohexameric interface [polypeptide binding]; other site 767455003792 elongation factor Ts; Provisional; Region: tsf; PRK09377 767455003793 Elongation factor TS; Region: EF_TS; pfam00889 767455003794 Elongation factor TS; Region: EF_TS; pfam00889 767455003795 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 767455003796 rRNA interaction site [nucleotide binding]; other site 767455003797 S8 interaction site; other site 767455003798 putative laminin-1 binding site; other site 767455003799 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 767455003800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767455003801 S-adenosylmethionine binding site [chemical binding]; other site 767455003802 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 767455003803 GIY-YIG motif/motif A; other site 767455003804 putative active site [active] 767455003805 putative metal binding site [ion binding]; other site 767455003806 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 767455003807 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 767455003808 putative acyl-acceptor binding pocket; other site 767455003809 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 767455003810 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 767455003811 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 767455003812 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 767455003813 hypothetical protein; Provisional; Region: PRK04435 767455003814 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 767455003815 DNA-binding interface [nucleotide binding]; DNA binding site 767455003816 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 767455003817 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767455003818 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767455003819 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 767455003820 Walker A/P-loop; other site 767455003821 ATP binding site [chemical binding]; other site 767455003822 Q-loop/lid; other site 767455003823 ABC transporter signature motif; other site 767455003824 Walker B; other site 767455003825 D-loop; other site 767455003826 H-loop/switch region; other site 767455003827 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 767455003828 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767455003829 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767455003830 Walker A/P-loop; other site 767455003831 ATP binding site [chemical binding]; other site 767455003832 Q-loop/lid; other site 767455003833 ABC transporter signature motif; other site 767455003834 Walker B; other site 767455003835 D-loop; other site 767455003836 H-loop/switch region; other site 767455003837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 767455003838 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 767455003839 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767455003840 putative DNA binding site [nucleotide binding]; other site 767455003841 LexA repressor; Validated; Region: PRK00215 767455003842 putative Zn2+ binding site [ion binding]; other site 767455003843 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 767455003844 Catalytic site [active] 767455003845 Sugar transport protein; Region: Sugar_transport; pfam06800 767455003846 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 767455003847 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767455003848 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767455003849 substrate binding pocket [chemical binding]; other site 767455003850 membrane-bound complex binding site; other site 767455003851 hinge residues; other site 767455003852 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 767455003853 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767455003854 ATP binding site [chemical binding]; other site 767455003855 putative Mg++ binding site [ion binding]; other site 767455003856 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767455003857 nucleotide binding region [chemical binding]; other site 767455003858 ATP-binding site [chemical binding]; other site 767455003859 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 767455003860 AAA ATPase domain; Region: AAA_16; pfam13191 767455003861 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 767455003862 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 767455003863 putative active site [active] 767455003864 putative metal binding site [ion binding]; other site 767455003865 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 767455003866 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 767455003867 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 767455003868 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 767455003869 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767455003870 ATP binding site [chemical binding]; other site 767455003871 putative Mg++ binding site [ion binding]; other site 767455003872 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767455003873 nucleotide binding region [chemical binding]; other site 767455003874 ATP-binding site [chemical binding]; other site 767455003875 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 767455003876 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 767455003877 RimM N-terminal domain; Region: RimM; pfam01782 767455003878 PRC-barrel domain; Region: PRC; pfam05239 767455003879 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 767455003880 signal recognition particle protein; Provisional; Region: PRK10867 767455003881 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 767455003882 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 767455003883 P loop; other site 767455003884 GTP binding site [chemical binding]; other site 767455003885 Signal peptide binding domain; Region: SRP_SPB; pfam02978 767455003886 putative DNA-binding protein; Validated; Region: PRK00118 767455003887 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 767455003888 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 767455003889 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 767455003890 P loop; other site 767455003891 GTP binding site [chemical binding]; other site 767455003892 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 767455003893 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 767455003894 Walker A/P-loop; other site 767455003895 ATP binding site [chemical binding]; other site 767455003896 Q-loop/lid; other site 767455003897 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 767455003898 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 767455003899 Q-loop/lid; other site 767455003900 ABC transporter signature motif; other site 767455003901 Walker B; other site 767455003902 D-loop; other site 767455003903 H-loop/switch region; other site 767455003904 ribonuclease III; Reviewed; Region: rnc; PRK00102 767455003905 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 767455003906 dimerization interface [polypeptide binding]; other site 767455003907 active site 767455003908 metal binding site [ion binding]; metal-binding site 767455003909 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 767455003910 dsRNA binding site [nucleotide binding]; other site 767455003911 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 767455003912 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 767455003913 peptide binding site [polypeptide binding]; other site 767455003914 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 767455003915 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 767455003916 peptide binding site [polypeptide binding]; other site 767455003917 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 767455003918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767455003919 dimer interface [polypeptide binding]; other site 767455003920 conserved gate region; other site 767455003921 putative PBP binding loops; other site 767455003922 ABC-ATPase subunit interface; other site 767455003923 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 767455003924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767455003925 dimer interface [polypeptide binding]; other site 767455003926 conserved gate region; other site 767455003927 putative PBP binding loops; other site 767455003928 ABC-ATPase subunit interface; other site 767455003929 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 767455003930 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 767455003931 Walker A/P-loop; other site 767455003932 ATP binding site [chemical binding]; other site 767455003933 Q-loop/lid; other site 767455003934 ABC transporter signature motif; other site 767455003935 Walker B; other site 767455003936 D-loop; other site 767455003937 H-loop/switch region; other site 767455003938 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 767455003939 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 767455003940 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 767455003941 Walker A/P-loop; other site 767455003942 ATP binding site [chemical binding]; other site 767455003943 Q-loop/lid; other site 767455003944 ABC transporter signature motif; other site 767455003945 Walker B; other site 767455003946 D-loop; other site 767455003947 H-loop/switch region; other site 767455003948 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 767455003949 acyl carrier protein; Provisional; Region: acpP; PRK00982 767455003950 putative phosphate acyltransferase; Provisional; Region: PRK05331 767455003951 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 767455003952 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 767455003953 ssDNA binding site; other site 767455003954 generic binding surface II; other site 767455003955 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767455003956 ATP binding site [chemical binding]; other site 767455003957 putative Mg++ binding site [ion binding]; other site 767455003958 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767455003959 nucleotide binding region [chemical binding]; other site 767455003960 ATP-binding site [chemical binding]; other site 767455003961 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 767455003962 DAK2 domain; Region: Dak2; pfam02734 767455003963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 767455003964 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 767455003965 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767455003966 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 767455003967 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 767455003968 Walker A/P-loop; other site 767455003969 ATP binding site [chemical binding]; other site 767455003970 Q-loop/lid; other site 767455003971 ABC transporter signature motif; other site 767455003972 Walker B; other site 767455003973 D-loop; other site 767455003974 H-loop/switch region; other site 767455003975 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 767455003976 Thiamine pyrophosphokinase; Region: TPK; cd07995 767455003977 active site 767455003978 dimerization interface [polypeptide binding]; other site 767455003979 thiamine binding site [chemical binding]; other site 767455003980 GTPase RsgA; Reviewed; Region: PRK00098 767455003981 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 767455003982 RNA binding site [nucleotide binding]; other site 767455003983 homodimer interface [polypeptide binding]; other site 767455003984 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 767455003985 GTPase/Zn-binding domain interface [polypeptide binding]; other site 767455003986 GTP/Mg2+ binding site [chemical binding]; other site 767455003987 G4 box; other site 767455003988 G1 box; other site 767455003989 Switch I region; other site 767455003990 G2 box; other site 767455003991 G3 box; other site 767455003992 Switch II region; other site 767455003993 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 767455003994 Catalytic domain of Protein Kinases; Region: PKc; cd00180 767455003995 active site 767455003996 ATP binding site [chemical binding]; other site 767455003997 substrate binding site [chemical binding]; other site 767455003998 activation loop (A-loop); other site 767455003999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 767455004000 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 767455004001 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 767455004002 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 767455004003 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 767455004004 active site 767455004005 16S rRNA methyltransferase B; Provisional; Region: PRK14902 767455004006 NusB family; Region: NusB; pfam01029 767455004007 putative RNA binding site [nucleotide binding]; other site 767455004008 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767455004009 S-adenosylmethionine binding site [chemical binding]; other site 767455004010 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 767455004011 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 767455004012 putative active site [active] 767455004013 substrate binding site [chemical binding]; other site 767455004014 putative cosubstrate binding site; other site 767455004015 catalytic site [active] 767455004016 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 767455004017 substrate binding site [chemical binding]; other site 767455004018 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 767455004019 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767455004020 ATP binding site [chemical binding]; other site 767455004021 putative Mg++ binding site [ion binding]; other site 767455004022 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767455004023 nucleotide binding region [chemical binding]; other site 767455004024 ATP-binding site [chemical binding]; other site 767455004025 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 767455004026 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 767455004027 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 767455004028 catalytic site [active] 767455004029 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 767455004030 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 767455004031 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 767455004032 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 767455004033 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 767455004034 Walker A/P-loop; other site 767455004035 ATP binding site [chemical binding]; other site 767455004036 Q-loop/lid; other site 767455004037 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 767455004038 ABC transporter signature motif; other site 767455004039 Walker B; other site 767455004040 D-loop; other site 767455004041 H-loop/switch region; other site 767455004042 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 767455004043 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767455004044 RNA binding surface [nucleotide binding]; other site 767455004045 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 767455004046 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 767455004047 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 767455004048 substrate binding pocket [chemical binding]; other site 767455004049 chain length determination region; other site 767455004050 substrate-Mg2+ binding site; other site 767455004051 catalytic residues [active] 767455004052 aspartate-rich region 1; other site 767455004053 active site lid residues [active] 767455004054 aspartate-rich region 2; other site 767455004055 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 767455004056 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 767455004057 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 767455004058 generic binding surface II; other site 767455004059 generic binding surface I; other site 767455004060 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 767455004061 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 767455004062 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 767455004063 homodimer interface [polypeptide binding]; other site 767455004064 NADP binding site [chemical binding]; other site 767455004065 substrate binding site [chemical binding]; other site 767455004066 transcription antitermination factor NusB; Region: nusB; TIGR01951 767455004067 Asp23 family; Region: Asp23; pfam03780 767455004068 elongation factor P; Validated; Region: PRK00529 767455004069 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 767455004070 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 767455004071 RNA binding site [nucleotide binding]; other site 767455004072 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 767455004073 RNA binding site [nucleotide binding]; other site 767455004074 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 767455004075 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 767455004076 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 767455004077 active site 767455004078 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 767455004079 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 767455004080 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 767455004081 ArsC family; Region: ArsC; pfam03960 767455004082 putative ArsC-like catalytic residues; other site 767455004083 putative TRX-like catalytic residues [active] 767455004084 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 767455004085 catalytic residue [active] 767455004086 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 767455004087 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767455004088 ABC transporter signature motif; other site 767455004089 Walker B; other site 767455004090 D-loop; other site 767455004091 H-loop/switch region; other site 767455004092 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 767455004093 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 767455004094 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 767455004095 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 767455004096 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 767455004097 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 767455004098 purine monophosphate binding site [chemical binding]; other site 767455004099 dimer interface [polypeptide binding]; other site 767455004100 putative catalytic residues [active] 767455004101 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 767455004102 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 767455004103 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 767455004104 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 767455004105 active site 767455004106 substrate binding site [chemical binding]; other site 767455004107 cosubstrate binding site; other site 767455004108 catalytic site [active] 767455004109 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 767455004110 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 767455004111 dimerization interface [polypeptide binding]; other site 767455004112 putative ATP binding site [chemical binding]; other site 767455004113 amidophosphoribosyltransferase; Provisional; Region: PRK07272 767455004114 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 767455004115 active site 767455004116 tetramer interface [polypeptide binding]; other site 767455004117 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767455004118 active site 767455004119 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 767455004120 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 767455004121 dimerization interface [polypeptide binding]; other site 767455004122 ATP binding site [chemical binding]; other site 767455004123 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 767455004124 dimerization interface [polypeptide binding]; other site 767455004125 ATP binding site [chemical binding]; other site 767455004126 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 767455004127 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 767455004128 putative active site [active] 767455004129 catalytic triad [active] 767455004130 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 767455004131 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 767455004132 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 767455004133 ATP binding site [chemical binding]; other site 767455004134 active site 767455004135 substrate binding site [chemical binding]; other site 767455004136 adenylosuccinate lyase; Provisional; Region: PRK07492 767455004137 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 767455004138 tetramer interface [polypeptide binding]; other site 767455004139 active site 767455004140 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 767455004141 ATP-grasp domain; Region: ATP-grasp; pfam02222 767455004142 AIR carboxylase; Region: AIRC; pfam00731 767455004143 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 767455004144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767455004145 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767455004146 putative substrate translocation pore; other site 767455004147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 767455004148 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 767455004149 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 767455004150 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 767455004151 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 767455004152 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 767455004153 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 767455004154 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 767455004155 DNA topoisomerase III; Provisional; Region: PRK07726 767455004156 active site 767455004157 putative interdomain interaction site [polypeptide binding]; other site 767455004158 putative metal-binding site [ion binding]; other site 767455004159 putative nucleotide binding site [chemical binding]; other site 767455004160 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 767455004161 domain I; other site 767455004162 DNA binding groove [nucleotide binding] 767455004163 phosphate binding site [ion binding]; other site 767455004164 domain II; other site 767455004165 domain III; other site 767455004166 nucleotide binding site [chemical binding]; other site 767455004167 catalytic site [active] 767455004168 domain IV; other site 767455004169 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 767455004170 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 767455004171 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 767455004172 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 767455004173 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 767455004174 proposed active site lysine [active] 767455004175 conserved cys residue [active] 767455004176 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 767455004177 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 767455004178 dimer interface [polypeptide binding]; other site 767455004179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767455004180 catalytic residue [active] 767455004181 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767455004182 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 767455004183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767455004184 S-adenosylmethionine binding site [chemical binding]; other site 767455004185 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 767455004186 active site 767455004187 Zn binding site [ion binding]; other site 767455004188 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767455004189 Helix-turn-helix domain; Region: HTH_38; pfam13936 767455004190 Integrase core domain; Region: rve; pfam00665 767455004191 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 767455004192 adenosine deaminase; Provisional; Region: PRK09358 767455004193 active site 767455004194 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 767455004195 EDD domain protein, DegV family; Region: DegV; TIGR00762 767455004196 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 767455004197 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767455004198 Helix-turn-helix domain; Region: HTH_38; pfam13936 767455004199 Integrase core domain; Region: rve; pfam00665 767455004200 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 767455004201 inner membrane transporter YjeM; Provisional; Region: PRK15238 767455004202 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 767455004203 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 767455004204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767455004205 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767455004206 putative substrate translocation pore; other site 767455004207 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 767455004208 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 767455004209 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 767455004210 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 767455004211 Aluminium resistance protein; Region: Alum_res; pfam06838 767455004212 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 767455004213 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 767455004214 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 767455004215 active site residue [active] 767455004216 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 767455004217 Rhomboid family; Region: Rhomboid; pfam01694 767455004218 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 767455004219 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 767455004220 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 767455004221 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 767455004222 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 767455004223 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 767455004224 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 767455004225 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 767455004226 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 767455004227 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 767455004228 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 767455004229 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 767455004230 putative tRNA-binding site [nucleotide binding]; other site 767455004231 B3/4 domain; Region: B3_4; pfam03483 767455004232 tRNA synthetase B5 domain; Region: B5; smart00874 767455004233 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 767455004234 dimer interface [polypeptide binding]; other site 767455004235 motif 1; other site 767455004236 motif 3; other site 767455004237 motif 2; other site 767455004238 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 767455004239 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 767455004240 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 767455004241 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 767455004242 dimer interface [polypeptide binding]; other site 767455004243 motif 1; other site 767455004244 active site 767455004245 motif 2; other site 767455004246 motif 3; other site 767455004247 Predicted transcriptional regulators [Transcription]; Region: COG1733 767455004248 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 767455004249 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 767455004250 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 767455004251 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 767455004252 Acylphosphatase; Region: Acylphosphatase; pfam00708 767455004253 OxaA-like protein precursor; Provisional; Region: PRK02463 767455004254 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 767455004255 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 767455004256 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767455004257 dimerization interface [polypeptide binding]; other site 767455004258 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767455004259 dimer interface [polypeptide binding]; other site 767455004260 phosphorylation site [posttranslational modification] 767455004261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767455004262 ATP binding site [chemical binding]; other site 767455004263 Mg2+ binding site [ion binding]; other site 767455004264 G-X-G motif; other site 767455004265 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767455004266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767455004267 active site 767455004268 phosphorylation site [posttranslational modification] 767455004269 intermolecular recognition site; other site 767455004270 dimerization interface [polypeptide binding]; other site 767455004271 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767455004272 DNA binding site [nucleotide binding] 767455004273 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 767455004274 hypothetical protein; Provisional; Region: PRK13670 767455004275 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 767455004276 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 767455004277 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767455004278 Zn2+ binding site [ion binding]; other site 767455004279 Mg2+ binding site [ion binding]; other site 767455004280 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 767455004281 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 767455004282 active site 767455004283 (T/H)XGH motif; other site 767455004284 GTPase YqeH; Provisional; Region: PRK13796 767455004285 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 767455004286 GTP/Mg2+ binding site [chemical binding]; other site 767455004287 G4 box; other site 767455004288 G5 box; other site 767455004289 G1 box; other site 767455004290 Switch I region; other site 767455004291 G2 box; other site 767455004292 G3 box; other site 767455004293 Switch II region; other site 767455004294 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 767455004295 23S rRNA binding site [nucleotide binding]; other site 767455004296 L21 binding site [polypeptide binding]; other site 767455004297 L13 binding site [polypeptide binding]; other site 767455004298 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 767455004299 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 767455004300 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 767455004301 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 767455004302 Archaeal ATPase; Region: Arch_ATPase; pfam01637 767455004303 AAA ATPase domain; Region: AAA_16; pfam13191 767455004304 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 767455004305 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 767455004306 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 767455004307 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 767455004308 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 767455004309 active site 767455004310 dimer interface [polypeptide binding]; other site 767455004311 motif 1; other site 767455004312 motif 2; other site 767455004313 motif 3; other site 767455004314 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 767455004315 anticodon binding site; other site 767455004316 primosomal protein DnaI; Reviewed; Region: PRK08939 767455004317 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 767455004318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767455004319 Walker A motif; other site 767455004320 ATP binding site [chemical binding]; other site 767455004321 Walker B motif; other site 767455004322 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 767455004323 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 767455004324 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 767455004325 ATP cone domain; Region: ATP-cone; pfam03477 767455004326 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 767455004327 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 767455004328 CoA-binding site [chemical binding]; other site 767455004329 ATP-binding [chemical binding]; other site 767455004330 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 767455004331 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 767455004332 DNA binding site [nucleotide binding] 767455004333 catalytic residue [active] 767455004334 H2TH interface [polypeptide binding]; other site 767455004335 putative catalytic residues [active] 767455004336 turnover-facilitating residue; other site 767455004337 intercalation triad [nucleotide binding]; other site 767455004338 8OG recognition residue [nucleotide binding]; other site 767455004339 putative reading head residues; other site 767455004340 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 767455004341 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 767455004342 DNA polymerase I; Provisional; Region: PRK05755 767455004343 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 767455004344 active site 767455004345 metal binding site 1 [ion binding]; metal-binding site 767455004346 putative 5' ssDNA interaction site; other site 767455004347 metal binding site 3; metal-binding site 767455004348 metal binding site 2 [ion binding]; metal-binding site 767455004349 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 767455004350 putative DNA binding site [nucleotide binding]; other site 767455004351 putative metal binding site [ion binding]; other site 767455004352 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 767455004353 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 767455004354 active site 767455004355 DNA binding site [nucleotide binding] 767455004356 catalytic site [active] 767455004357 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 767455004358 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 767455004359 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 767455004360 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 767455004361 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 767455004362 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 767455004363 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 767455004364 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 767455004365 legume lectins; Region: lectin_L-type; cd01951 767455004366 homotetramer interaction site [polypeptide binding]; other site 767455004367 carbohydrate binding site [chemical binding]; other site 767455004368 metal binding site [ion binding]; metal-binding site 767455004369 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 767455004370 MucBP domain; Region: MucBP; pfam06458 767455004371 MucBP domain; Region: MucBP; pfam06458 767455004372 MucBP domain; Region: MucBP; pfam06458 767455004373 MobA/MobL family; Region: MobA_MobL; pfam03389 767455004374 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 767455004375 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767455004376 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 767455004377 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 767455004378 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767455004379 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767455004380 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 767455004381 putative tRNA-binding site [nucleotide binding]; other site 767455004382 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 767455004383 catalytic residues [active] 767455004384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767455004385 S-adenosylmethionine binding site [chemical binding]; other site 767455004386 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 767455004387 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767455004388 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767455004389 Walker A/P-loop; other site 767455004390 ATP binding site [chemical binding]; other site 767455004391 Q-loop/lid; other site 767455004392 ABC transporter signature motif; other site 767455004393 Walker B; other site 767455004394 D-loop; other site 767455004395 H-loop/switch region; other site 767455004396 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 767455004397 HIT family signature motif; other site 767455004398 catalytic residue [active] 767455004399 YtxH-like protein; Region: YtxH; pfam12732 767455004400 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 767455004401 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 767455004402 heterodimer interface [polypeptide binding]; other site 767455004403 active site 767455004404 FMN binding site [chemical binding]; other site 767455004405 homodimer interface [polypeptide binding]; other site 767455004406 substrate binding site [chemical binding]; other site 767455004407 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 767455004408 active site 767455004409 dimer interface [polypeptide binding]; other site 767455004410 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767455004411 active site 767455004412 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 767455004413 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 767455004414 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cl00323 767455004415 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 767455004416 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 767455004417 ADP binding site [chemical binding]; other site 767455004418 magnesium binding site [ion binding]; other site 767455004419 putative shikimate binding site; other site 767455004420 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 767455004421 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 767455004422 generic binding surface II; other site 767455004423 generic binding surface I; other site 767455004424 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767455004425 Zn2+ binding site [ion binding]; other site 767455004426 Mg2+ binding site [ion binding]; other site 767455004427 P-loop containing region of AAA domain; Region: AAA_29; cl17516 767455004428 AAA domain; Region: AAA_23; pfam13476 767455004429 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 767455004430 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767455004431 active site 767455004432 metal binding site [ion binding]; metal-binding site 767455004433 DNA binding site [nucleotide binding] 767455004434 hypothetical protein; Provisional; Region: PRK13676 767455004435 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 767455004436 Transglycosylase; Region: Transgly; pfam00912 767455004437 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 767455004438 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 767455004439 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 767455004440 active site 767455004441 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 767455004442 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 767455004443 intersubunit interface [polypeptide binding]; other site 767455004444 active site 767455004445 zinc binding site [ion binding]; other site 767455004446 Na+ binding site [ion binding]; other site 767455004447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 767455004448 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 767455004449 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 767455004450 active site 767455004451 catalytic site [active] 767455004452 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 767455004453 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 767455004454 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 767455004455 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 767455004456 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767455004457 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 767455004458 Rib/alpha-like repeat; Region: Rib; cl07159 767455004459 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 767455004460 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 767455004461 putative substrate binding site [chemical binding]; other site 767455004462 putative ATP binding site [chemical binding]; other site 767455004463 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 767455004464 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 767455004465 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 767455004466 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 767455004467 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 767455004468 PYR/PP interface [polypeptide binding]; other site 767455004469 dimer interface [polypeptide binding]; other site 767455004470 tetramer interface [polypeptide binding]; other site 767455004471 TPP binding site [chemical binding]; other site 767455004472 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 767455004473 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 767455004474 TPP-binding site [chemical binding]; other site 767455004475 phosphoenolpyruvate synthase; Validated; Region: PRK06464 767455004476 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 767455004477 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 767455004478 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 767455004479 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 767455004480 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 767455004481 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 767455004482 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 767455004483 HIGH motif; other site 767455004484 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 767455004485 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 767455004486 active site 767455004487 KMSKS motif; other site 767455004488 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 767455004489 tRNA binding surface [nucleotide binding]; other site 767455004490 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 767455004491 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 767455004492 active site 767455004493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767455004494 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767455004495 putative substrate translocation pore; other site 767455004496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767455004497 S-adenosylmethionine synthetase; Validated; Region: PRK05250 767455004498 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 767455004499 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 767455004500 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 767455004501 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 767455004502 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767455004503 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767455004504 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 767455004505 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 767455004506 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 767455004507 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 767455004508 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767455004509 active site 767455004510 motif I; other site 767455004511 motif II; other site 767455004512 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767455004513 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 767455004514 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 767455004515 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767455004516 active site 767455004517 metal binding site [ion binding]; metal-binding site 767455004518 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 767455004519 catabolite control protein A; Region: ccpA; TIGR01481 767455004520 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767455004521 DNA binding site [nucleotide binding] 767455004522 domain linker motif; other site 767455004523 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 767455004524 dimerization interface [polypeptide binding]; other site 767455004525 effector binding site; other site 767455004526 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 767455004527 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 767455004528 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 767455004529 active site 767455004530 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 767455004531 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 767455004532 Mechanosensitive ion channel; Region: MS_channel; pfam00924 767455004533 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 767455004534 active site 767455004535 dimerization interface [polypeptide binding]; other site 767455004536 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 767455004537 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 767455004538 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 767455004539 catalytic residues [active] 767455004540 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 767455004541 MutS domain III; Region: MutS_III; pfam05192 767455004542 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 767455004543 Walker A/P-loop; other site 767455004544 ATP binding site [chemical binding]; other site 767455004545 Q-loop/lid; other site 767455004546 ABC transporter signature motif; other site 767455004547 Walker B; other site 767455004548 D-loop; other site 767455004549 H-loop/switch region; other site 767455004550 Smr domain; Region: Smr; pfam01713 767455004551 hypothetical protein; Provisional; Region: PRK13678 767455004552 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 767455004553 hypothetical protein; Provisional; Region: PRK05473 767455004554 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 767455004555 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 767455004556 motif 1; other site 767455004557 active site 767455004558 motif 2; other site 767455004559 motif 3; other site 767455004560 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 767455004561 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 767455004562 DEAD-like helicases superfamily; Region: DEXDc; smart00487 767455004563 ATP binding site [chemical binding]; other site 767455004564 putative Mg++ binding site [ion binding]; other site 767455004565 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767455004566 nucleotide binding region [chemical binding]; other site 767455004567 ATP-binding site [chemical binding]; other site 767455004568 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 767455004569 DHH family; Region: DHH; pfam01368 767455004570 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 767455004571 active site 767455004572 DNA polymerase IV; Validated; Region: PRK02406 767455004573 DNA binding site [nucleotide binding] 767455004574 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 767455004575 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 767455004576 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 767455004577 Preprotein translocase subunit; Region: YajC; pfam02699 767455004578 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 767455004579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767455004580 Walker A motif; other site 767455004581 ATP binding site [chemical binding]; other site 767455004582 Walker B motif; other site 767455004583 arginine finger; other site 767455004584 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 767455004585 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 767455004586 RuvA N terminal domain; Region: RuvA_N; pfam01330 767455004587 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 767455004588 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 767455004589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767455004590 ATP binding site [chemical binding]; other site 767455004591 Mg2+ binding site [ion binding]; other site 767455004592 G-X-G motif; other site 767455004593 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 767455004594 ATP binding site [chemical binding]; other site 767455004595 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 767455004596 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 767455004597 MutS domain I; Region: MutS_I; pfam01624 767455004598 MutS domain II; Region: MutS_II; pfam05188 767455004599 MutS domain III; Region: MutS_III; pfam05192 767455004600 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 767455004601 Walker A/P-loop; other site 767455004602 ATP binding site [chemical binding]; other site 767455004603 Q-loop/lid; other site 767455004604 ABC transporter signature motif; other site 767455004605 Walker B; other site 767455004606 D-loop; other site 767455004607 H-loop/switch region; other site 767455004608 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 767455004609 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 767455004610 ring oligomerisation interface [polypeptide binding]; other site 767455004611 ATP/Mg binding site [chemical binding]; other site 767455004612 stacking interactions; other site 767455004613 hinge regions; other site 767455004614 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 767455004615 mobile loop; other site 767455004616 oligomerisation interface [polypeptide binding]; other site 767455004617 roof hairpin; other site 767455004618 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 767455004619 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 767455004620 CoA binding domain; Region: CoA_binding; pfam02629 767455004621 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 767455004622 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767455004623 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767455004624 ABC transporter; Region: ABC_tran_2; pfam12848 767455004625 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767455004626 UGMP family protein; Validated; Region: PRK09604 767455004627 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 767455004628 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 767455004629 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767455004630 Coenzyme A binding pocket [chemical binding]; other site 767455004631 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 767455004632 Glycoprotease family; Region: Peptidase_M22; pfam00814 767455004633 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 767455004634 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 767455004635 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 767455004636 active site 767455004637 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 767455004638 active site 767455004639 Predicted methyltransferases [General function prediction only]; Region: COG0313 767455004640 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 767455004641 putative SAM binding site [chemical binding]; other site 767455004642 putative homodimer interface [polypeptide binding]; other site 767455004643 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 767455004644 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 767455004645 DNA polymerase III subunit delta'; Validated; Region: PRK08485 767455004646 Protein of unknown function (DUF970); Region: DUF970; cl17525 767455004647 thymidylate kinase; Validated; Region: tmk; PRK00698 767455004648 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 767455004649 TMP-binding site; other site 767455004650 ATP-binding site [chemical binding]; other site 767455004651 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 767455004652 recombination protein RecR; Reviewed; Region: recR; PRK00076 767455004653 RecR protein; Region: RecR; pfam02132 767455004654 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 767455004655 putative active site [active] 767455004656 putative metal-binding site [ion binding]; other site 767455004657 tetramer interface [polypeptide binding]; other site 767455004658 hypothetical protein; Validated; Region: PRK00153 767455004659 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 767455004660 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767455004661 Walker A motif; other site 767455004662 ATP binding site [chemical binding]; other site 767455004663 Walker B motif; other site 767455004664 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 767455004665 nucleoside/Zn binding site; other site 767455004666 dimer interface [polypeptide binding]; other site 767455004667 catalytic motif [active] 767455004668 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 767455004669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767455004670 S-adenosylmethionine binding site [chemical binding]; other site 767455004671 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 767455004672 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767455004673 active site 767455004674 Bacterial surface layer protein; Region: SLAP; pfam03217 767455004675 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 767455004676 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 767455004677 Beta-lactamase; Region: Beta-lactamase; pfam00144 767455004678 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 767455004679 Beta-lactamase; Region: Beta-lactamase; pfam00144 767455004680 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 767455004681 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 767455004682 IHF dimer interface [polypeptide binding]; other site 767455004683 IHF - DNA interface [nucleotide binding]; other site 767455004684 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 767455004685 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767455004686 Helix-turn-helix domain; Region: HTH_38; pfam13936 767455004687 Integrase core domain; Region: rve; pfam00665 767455004688 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 767455004689 core dimer interface [polypeptide binding]; other site 767455004690 peripheral dimer interface [polypeptide binding]; other site 767455004691 L10 interface [polypeptide binding]; other site 767455004692 L11 interface [polypeptide binding]; other site 767455004693 putative EF-Tu interaction site [polypeptide binding]; other site 767455004694 putative EF-G interaction site [polypeptide binding]; other site 767455004695 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 767455004696 23S rRNA interface [nucleotide binding]; other site 767455004697 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 767455004698 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 767455004699 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 767455004700 active site 767455004701 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 767455004702 mRNA/rRNA interface [nucleotide binding]; other site 767455004703 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 767455004704 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 767455004705 23S rRNA interface [nucleotide binding]; other site 767455004706 L7/L12 interface [polypeptide binding]; other site 767455004707 putative thiostrepton binding site; other site 767455004708 L25 interface [polypeptide binding]; other site 767455004709 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 767455004710 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 767455004711 putative homodimer interface [polypeptide binding]; other site 767455004712 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 767455004713 heterodimer interface [polypeptide binding]; other site 767455004714 homodimer interface [polypeptide binding]; other site 767455004715 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 767455004716 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 767455004717 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 767455004718 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 767455004719 TPP-binding site; other site 767455004720 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 767455004721 PYR/PP interface [polypeptide binding]; other site 767455004722 dimer interface [polypeptide binding]; other site 767455004723 TPP binding site [chemical binding]; other site 767455004724 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 767455004725 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 767455004726 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 767455004727 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767455004728 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 767455004729 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 767455004730 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 767455004731 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 767455004732 active site 767455004733 metal binding site [ion binding]; metal-binding site 767455004734 dimerization interface [polypeptide binding]; other site 767455004735 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 767455004736 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 767455004737 active site 767455004738 HIGH motif; other site 767455004739 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 767455004740 KMSKS motif; other site 767455004741 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 767455004742 tRNA binding surface [nucleotide binding]; other site 767455004743 anticodon binding site; other site 767455004744 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 767455004745 nudix motif; other site 767455004746 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 767455004747 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 767455004748 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 767455004749 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767455004750 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767455004751 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 767455004752 dimerization interface [polypeptide binding]; other site 767455004753 Predicted membrane protein [Function unknown]; Region: COG2855 767455004754 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 767455004755 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 767455004756 HIGH motif; other site 767455004757 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 767455004758 active site 767455004759 KMSKS motif; other site 767455004760 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767455004761 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767455004762 Walker A/P-loop; other site 767455004763 ATP binding site [chemical binding]; other site 767455004764 Q-loop/lid; other site 767455004765 ABC transporter signature motif; other site 767455004766 Walker B; other site 767455004767 D-loop; other site 767455004768 H-loop/switch region; other site 767455004769 Predicted transcriptional regulators [Transcription]; Region: COG1725 767455004770 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767455004771 DNA-binding site [nucleotide binding]; DNA binding site 767455004772 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 767455004773 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 767455004774 peptide binding site [polypeptide binding]; other site 767455004775 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 767455004776 ADP-ribose binding site [chemical binding]; other site 767455004777 dimer interface [polypeptide binding]; other site 767455004778 active site 767455004779 nudix motif; other site 767455004780 metal binding site [ion binding]; metal-binding site 767455004781 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 767455004782 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 767455004783 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 767455004784 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 767455004785 active site 767455004786 Substrate binding site; other site 767455004787 Mg++ binding site; other site 767455004788 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 767455004789 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 767455004790 substrate binding site [chemical binding]; other site 767455004791 ATP binding site [chemical binding]; other site 767455004792 H+ Antiporter protein; Region: 2A0121; TIGR00900 767455004793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767455004794 putative substrate translocation pore; other site 767455004795 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 767455004796 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 767455004797 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 767455004798 active site 767455004799 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 767455004800 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 767455004801 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 767455004802 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 767455004803 putative catalytic cysteine [active] 767455004804 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 767455004805 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767455004806 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767455004807 Walker A/P-loop; other site 767455004808 ATP binding site [chemical binding]; other site 767455004809 Q-loop/lid; other site 767455004810 ABC transporter signature motif; other site 767455004811 Walker B; other site 767455004812 D-loop; other site 767455004813 H-loop/switch region; other site 767455004814 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 767455004815 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767455004816 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767455004817 Walker A/P-loop; other site 767455004818 ATP binding site [chemical binding]; other site 767455004819 Q-loop/lid; other site 767455004820 ABC transporter signature motif; other site 767455004821 Walker B; other site 767455004822 D-loop; other site 767455004823 H-loop/switch region; other site 767455004824 hypothetical protein; Provisional; Region: PRK13661 767455004825 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767455004826 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767455004827 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 767455004828 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cd04761 767455004829 DNA binding residues [nucleotide binding] 767455004830 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 767455004831 catalytic residues [active] 767455004832 catalytic nucleophile [active] 767455004833 Uncharacterized conserved protein [Function unknown]; Region: COG1912 767455004834 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 767455004835 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 767455004836 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 767455004837 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767455004838 Walker A/P-loop; other site 767455004839 ATP binding site [chemical binding]; other site 767455004840 Q-loop/lid; other site 767455004841 ABC transporter signature motif; other site 767455004842 Walker B; other site 767455004843 D-loop; other site 767455004844 H-loop/switch region; other site 767455004845 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767455004846 DNA-binding site [nucleotide binding]; DNA binding site 767455004847 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 767455004848 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 767455004849 Ligand binding site; other site 767455004850 metal-binding site 767455004851 DNA repair protein RadA; Provisional; Region: PRK11823 767455004852 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 767455004853 Walker A motif/ATP binding site; other site 767455004854 ATP binding site [chemical binding]; other site 767455004855 Walker B motif; other site 767455004856 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 767455004857 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 767455004858 trimer interface [polypeptide binding]; other site 767455004859 active site 767455004860 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 767455004861 trimer interface [polypeptide binding]; other site 767455004862 active site 767455004863 G bulge; other site 767455004864 AAA domain; Region: AAA_33; pfam13671 767455004865 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 767455004866 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767455004867 catalytic core [active] 767455004868 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767455004869 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767455004870 catalytic core [active] 767455004871 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767455004872 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 767455004873 hypothetical protein; Provisional; Region: PRK10621 767455004874 DJ-1 family protein; Region: not_thiJ; TIGR01383 767455004875 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 767455004876 conserved cys residue [active] 767455004877 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767455004878 Coenzyme A binding pocket [chemical binding]; other site 767455004879 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 767455004880 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 767455004881 active site 767455004882 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 767455004883 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 767455004884 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 767455004885 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 767455004886 dipeptidase PepV; Region: dipeptidase; TIGR01886 767455004887 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 767455004888 active site 767455004889 metal binding site [ion binding]; metal-binding site 767455004890 aromatic amino acid transporter; Provisional; Region: PRK10238 767455004891 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 767455004892 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 767455004893 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 767455004894 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 767455004895 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 767455004896 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 767455004897 active site 767455004898 catalytic residues [active] 767455004899 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 767455004900 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 767455004901 putative substrate binding site [chemical binding]; other site 767455004902 putative ATP binding site [chemical binding]; other site 767455004903 Class I aldolases; Region: Aldolase_Class_I; cl17187 767455004904 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 767455004905 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 767455004906 Phosphotransferase system, galactitol-specific IIB component [Carbohydrate transport and metabolism]; Region: SgaB; COG3414 767455004907 active site 767455004908 P-loop; other site 767455004909 phosphorylation site [posttranslational modification] 767455004910 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 767455004911 active site 767455004912 phosphorylation site [posttranslational modification] 767455004913 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 767455004914 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 767455004915 beta-galactosidase; Region: BGL; TIGR03356 767455004916 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 767455004917 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 767455004918 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 767455004919 active site 767455004920 P-loop; other site 767455004921 phosphorylation site [posttranslational modification] 767455004922 PRD domain; Region: PRD; pfam00874 767455004923 PRD domain; Region: PRD; pfam00874 767455004924 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 767455004925 methionine cluster; other site 767455004926 active site 767455004927 phosphorylation site [posttranslational modification] 767455004928 metal binding site [ion binding]; metal-binding site 767455004929 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 767455004930 active site 767455004931 catalytic residues [active] 767455004932 galactokinase; Provisional; Region: PRK05322 767455004933 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 767455004934 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 767455004935 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 767455004936 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 767455004937 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 767455004938 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 767455004939 Aspartase; Region: Aspartase; cd01357 767455004940 active sites [active] 767455004941 tetramer interface [polypeptide binding]; other site 767455004942 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767455004943 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 767455004944 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 767455004945 homoserine kinase; Provisional; Region: PRK01212 767455004946 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 767455004947 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 767455004948 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 767455004949 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 767455004950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767455004951 catalytic residue [active] 767455004952 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 767455004953 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767455004954 Coenzyme A binding pocket [chemical binding]; other site 767455004955 Transcriptional regulators [Transcription]; Region: PurR; COG1609 767455004956 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767455004957 DNA binding site [nucleotide binding] 767455004958 domain linker motif; other site 767455004959 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 767455004960 dimerization interface [polypeptide binding]; other site 767455004961 ligand binding site [chemical binding]; other site 767455004962 sodium binding site [ion binding]; other site 767455004963 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 767455004964 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 767455004965 substrate binding [chemical binding]; other site 767455004966 active site 767455004967 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 767455004968 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 767455004969 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 767455004970 active site turn [active] 767455004971 phosphorylation site [posttranslational modification] 767455004972 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 767455004973 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 767455004974 HPr interaction site; other site 767455004975 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767455004976 active site 767455004977 phosphorylation site [posttranslational modification] 767455004978 6-phosphofructokinase; Provisional; Region: PRK03202 767455004979 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 767455004980 active site 767455004981 ADP/pyrophosphate binding site [chemical binding]; other site 767455004982 dimerization interface [polypeptide binding]; other site 767455004983 allosteric effector site; other site 767455004984 fructose-1,6-bisphosphate binding site; other site 767455004985 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 767455004986 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 767455004987 active site 767455004988 substrate binding site [chemical binding]; other site 767455004989 metal binding site [ion binding]; metal-binding site 767455004990 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 767455004991 short chain dehydrogenase; Validated; Region: PRK06182 767455004992 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 767455004993 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 767455004994 active site 767455004995 catalytic site [active] 767455004996 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 767455004997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767455004998 putative substrate translocation pore; other site 767455004999 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767455005000 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767455005001 non-specific DNA binding site [nucleotide binding]; other site 767455005002 salt bridge; other site 767455005003 sequence-specific DNA binding site [nucleotide binding]; other site 767455005004 Probable transposase; Region: OrfB_IS605; pfam01385 767455005005 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767455005006 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767455005007 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 767455005008 PLD-like domain; Region: PLDc_2; pfam13091 767455005009 putative homodimer interface [polypeptide binding]; other site 767455005010 putative active site [active] 767455005011 catalytic site [active] 767455005012 DEAD-like helicases superfamily; Region: DEXDc; smart00487 767455005013 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767455005014 ATP binding site [chemical binding]; other site 767455005015 putative Mg++ binding site [ion binding]; other site 767455005016 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 767455005017 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767455005018 nucleotide binding region [chemical binding]; other site 767455005019 ATP-binding site [chemical binding]; other site 767455005020 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 767455005021 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 767455005022 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 767455005023 NAD binding site [chemical binding]; other site 767455005024 homodimer interface [polypeptide binding]; other site 767455005025 active site 767455005026 substrate binding site [chemical binding]; other site 767455005027 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 767455005028 NlpC/P60 family; Region: NLPC_P60; pfam00877 767455005029 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 767455005030 Spore germination protein; Region: Spore_permease; cl17796 767455005031 Domain of unknown function (DUF956); Region: DUF956; pfam06115 767455005032 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 767455005033 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 767455005034 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 767455005035 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 767455005036 active pocket/dimerization site; other site 767455005037 active site 767455005038 phosphorylation site [posttranslational modification] 767455005039 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 767455005040 active site 767455005041 phosphorylation site [posttranslational modification] 767455005042 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767455005043 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 767455005044 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 767455005045 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767455005046 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767455005047 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 767455005048 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cd04761 767455005049 DNA binding residues [nucleotide binding] 767455005050 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 767455005051 catalytic residues [active] 767455005052 catalytic nucleophile [active] 767455005053 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 767455005054 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767455005055 Walker A/P-loop; other site 767455005056 ATP binding site [chemical binding]; other site 767455005057 Q-loop/lid; other site 767455005058 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 767455005059 FeS assembly protein SufB; Region: sufB; TIGR01980 767455005060 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 767455005061 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 767455005062 trimerization site [polypeptide binding]; other site 767455005063 active site 767455005064 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 767455005065 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 767455005066 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767455005067 catalytic residue [active] 767455005068 FeS assembly protein SufD; Region: sufD; TIGR01981 767455005069 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 767455005070 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 767455005071 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 767455005072 Walker A/P-loop; other site 767455005073 ATP binding site [chemical binding]; other site 767455005074 Q-loop/lid; other site 767455005075 ABC transporter signature motif; other site 767455005076 Walker B; other site 767455005077 D-loop; other site 767455005078 H-loop/switch region; other site 767455005079 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767455005080 Coenzyme A binding pocket [chemical binding]; other site 767455005081 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 767455005082 HPr interaction site; other site 767455005083 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767455005084 active site 767455005085 phosphorylation site [posttranslational modification] 767455005086 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 767455005087 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 767455005088 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 767455005089 putative active site [active] 767455005090 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 767455005091 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 767455005092 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 767455005093 active site turn [active] 767455005094 phosphorylation site [posttranslational modification] 767455005095 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 767455005096 active site turn [active] 767455005097 phosphorylation site [posttranslational modification] 767455005098 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 767455005099 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 767455005100 NAD binding site [chemical binding]; other site 767455005101 sugar binding site [chemical binding]; other site 767455005102 divalent metal binding site [ion binding]; other site 767455005103 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 767455005104 dimer interface [polypeptide binding]; other site 767455005105 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 767455005106 SmpB-tmRNA interface; other site 767455005107 ribonuclease R; Region: RNase_R; TIGR02063 767455005108 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 767455005109 RNB domain; Region: RNB; pfam00773 767455005110 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 767455005111 RNA binding site [nucleotide binding]; other site 767455005112 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 767455005113 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 767455005114 Sulfatase; Region: Sulfatase; pfam00884 767455005115 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 767455005116 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 767455005117 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767455005118 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767455005119 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 767455005120 putative ADP-binding pocket [chemical binding]; other site 767455005121 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 767455005122 arginine deiminase; Provisional; Region: PRK01388 767455005123 carbamate kinase; Reviewed; Region: PRK12686 767455005124 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 767455005125 putative substrate binding site [chemical binding]; other site 767455005126 nucleotide binding site [chemical binding]; other site 767455005127 nucleotide binding site [chemical binding]; other site 767455005128 homodimer interface [polypeptide binding]; other site 767455005129 ornithine carbamoyltransferase; Provisional; Region: PRK04284 767455005130 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 767455005131 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 767455005132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 767455005133 active site 767455005134 dimerization interface [polypeptide binding]; other site 767455005135 YcbB domain; Region: YcbB; pfam08664 767455005136 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 767455005137 B3/4 domain; Region: B3_4; pfam03483 767455005138 potential frameshift: common BLAST hit: gi|148545131|ref|YP_001272501.1| amidohydrolase 3 767455005139 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 767455005140 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 767455005141 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 767455005142 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 767455005143 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767455005144 seryl-tRNA synthetase; Provisional; Region: PRK05431 767455005145 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 767455005146 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 767455005147 dimer interface [polypeptide binding]; other site 767455005148 active site 767455005149 motif 1; other site 767455005150 motif 2; other site 767455005151 motif 3; other site 767455005152 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 767455005153 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 767455005154 Uncharacterized conserved protein [Function unknown]; Region: COG0398 767455005155 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 767455005156 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 767455005157 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767455005158 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767455005159 non-specific DNA binding site [nucleotide binding]; other site 767455005160 salt bridge; other site 767455005161 sequence-specific DNA binding site [nucleotide binding]; other site 767455005162 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 767455005163 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 767455005164 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 767455005165 catalytic triad [active] 767455005166 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 767455005167 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 767455005168 NAD(P) binding site [chemical binding]; other site 767455005169 catalytic residues [active] 767455005170 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 767455005171 MMPL family; Region: MMPL; pfam03176 767455005172 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 767455005173 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 767455005174 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 767455005175 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 767455005176 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767455005177 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767455005178 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 767455005179 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 767455005180 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 767455005181 Cl binding site [ion binding]; other site 767455005182 oligomer interface [polypeptide binding]; other site 767455005183 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 767455005184 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 767455005185 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767455005186 Coenzyme A binding pocket [chemical binding]; other site 767455005187 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 767455005188 Peptidase family C69; Region: Peptidase_C69; cl17793 767455005189 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 767455005190 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 767455005191 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 767455005192 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 767455005193 active site 767455005194 catalytic tetrad [active] 767455005195 PAS domain; Region: PAS_10; pfam13596 767455005196 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767455005197 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767455005198 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 767455005199 Walker A/P-loop; other site 767455005200 ATP binding site [chemical binding]; other site 767455005201 Q-loop/lid; other site 767455005202 ABC transporter signature motif; other site 767455005203 Walker B; other site 767455005204 D-loop; other site 767455005205 H-loop/switch region; other site 767455005206 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 767455005207 TAP-like protein; Region: Abhydrolase_4; pfam08386 767455005208 Helix-turn-helix domain; Region: HTH_25; pfam13413 767455005209 elongation factor P; Validated; Region: PRK00529 767455005210 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 767455005211 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 767455005212 RNA binding site [nucleotide binding]; other site 767455005213 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 767455005214 RNA binding site [nucleotide binding]; other site 767455005215 pantothenate kinase; Provisional; Region: PRK05439 767455005216 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 767455005217 ATP-binding site [chemical binding]; other site 767455005218 CoA-binding site [chemical binding]; other site 767455005219 Mg2+-binding site [ion binding]; other site 767455005220 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 767455005221 active site 767455005222 catalytic triad [active] 767455005223 oxyanion hole [active] 767455005224 LytTr DNA-binding domain; Region: LytTR; smart00850 767455005225 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 767455005226 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767455005227 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767455005228 substrate binding pocket [chemical binding]; other site 767455005229 membrane-bound complex binding site; other site 767455005230 hinge residues; other site 767455005231 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767455005232 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767455005233 Walker A/P-loop; other site 767455005234 ATP binding site [chemical binding]; other site 767455005235 Q-loop/lid; other site 767455005236 ABC transporter signature motif; other site 767455005237 Walker B; other site 767455005238 D-loop; other site 767455005239 H-loop/switch region; other site 767455005240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767455005241 dimer interface [polypeptide binding]; other site 767455005242 conserved gate region; other site 767455005243 putative PBP binding loops; other site 767455005244 ABC-ATPase subunit interface; other site 767455005245 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 767455005246 Part of AAA domain; Region: AAA_19; pfam13245 767455005247 Family description; Region: UvrD_C_2; pfam13538 767455005248 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 767455005249 active site 767455005250 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767455005251 catalytic core [active] 767455005252 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 767455005253 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 767455005254 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 767455005255 active site 767455005256 catalytic site [active] 767455005257 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 767455005258 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 767455005259 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 767455005260 active site 767455005261 metal binding site [ion binding]; metal-binding site 767455005262 VanZ like family; Region: VanZ; pfam04892 767455005263 Predicted membrane protein [Function unknown]; Region: COG2246 767455005264 GtrA-like protein; Region: GtrA; pfam04138 767455005265 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 767455005266 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 767455005267 Transposase [DNA replication, recombination, and repair]; Region: COG5421 767455005268 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767455005269 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 767455005270 active site 767455005271 nucleotide binding site [chemical binding]; other site 767455005272 HIGH motif; other site 767455005273 KMSKS motif; other site 767455005274 LicD family; Region: LicD; cl01378 767455005275 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767455005276 Integrase core domain; Region: rve; pfam00665 767455005277 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 767455005278 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 767455005279 putative ADP-binding pocket [chemical binding]; other site 767455005280 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767455005281 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 767455005282 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 767455005283 Probable Catalytic site; other site 767455005284 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 767455005285 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 767455005286 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 767455005287 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767455005288 UDP-galactopyranose mutase; Region: GLF; pfam03275 767455005289 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 767455005290 Bacterial sugar transferase; Region: Bac_transf; pfam02397 767455005291 Core-2/I-Branching enzyme; Region: Branch; pfam02485 767455005292 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 767455005293 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 767455005294 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 767455005295 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767455005296 non-specific DNA binding site [nucleotide binding]; other site 767455005297 salt bridge; other site 767455005298 sequence-specific DNA binding site [nucleotide binding]; other site 767455005299 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 767455005300 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 767455005301 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 767455005302 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 767455005303 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 767455005304 putative active site [active] 767455005305 heme pocket [chemical binding]; other site 767455005306 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767455005307 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767455005308 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767455005309 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 767455005310 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cd04761 767455005311 DNA binding residues [nucleotide binding] 767455005312 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 767455005313 catalytic residues [active] 767455005314 catalytic nucleophile [active] 767455005315 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 767455005316 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 767455005317 active site turn [active] 767455005318 phosphorylation site [posttranslational modification] 767455005319 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 767455005320 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 767455005321 HPr interaction site; other site 767455005322 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767455005323 active site 767455005324 phosphorylation site [posttranslational modification] 767455005325 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 767455005326 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767455005327 DNA-binding site [nucleotide binding]; DNA binding site 767455005328 UTRA domain; Region: UTRA; pfam07702 767455005329 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 767455005330 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 767455005331 Ca binding site [ion binding]; other site 767455005332 active site 767455005333 catalytic site [active] 767455005334 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 767455005335 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cd04761 767455005336 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 767455005337 DNA binding residues [nucleotide binding] 767455005338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 767455005339 ABC transporter signature motif; other site 767455005340 Walker B; other site 767455005341 D-loop; other site 767455005342 H-loop/switch region; other site 767455005343 methionine sulfoxide reductase B; Provisional; Region: PRK00222 767455005344 SelR domain; Region: SelR; pfam01641 767455005345 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 767455005346 sequence-specific DNA binding site [nucleotide binding]; other site 767455005347 salt bridge; other site 767455005348 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 767455005349 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 767455005350 NADP binding site [chemical binding]; other site 767455005351 active site 767455005352 putative substrate binding site [chemical binding]; other site 767455005353 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 767455005354 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 767455005355 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 767455005356 substrate binding site; other site 767455005357 tetramer interface; other site 767455005358 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 767455005359 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 767455005360 NAD binding site [chemical binding]; other site 767455005361 substrate binding site [chemical binding]; other site 767455005362 homodimer interface [polypeptide binding]; other site 767455005363 active site 767455005364 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 767455005365 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 767455005366 DNA binding residues [nucleotide binding] 767455005367 dimer interface [polypeptide binding]; other site 767455005368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767455005369 S-adenosylmethionine binding site [chemical binding]; other site 767455005370 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 767455005371 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767455005372 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 767455005373 amphipathic channel; other site 767455005374 Asn-Pro-Ala signature motifs; other site 767455005375 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 767455005376 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 767455005377 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 767455005378 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 767455005379 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 767455005380 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 767455005381 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 767455005382 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 767455005383 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 767455005384 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 767455005385 Transposase [DNA replication, recombination, and repair]; Region: COG5421 767455005386 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767455005387 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 767455005388 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767455005389 UDP-galactopyranose mutase; Region: GLF; pfam03275 767455005390 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 767455005391 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 767455005392 active site 767455005393 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 767455005394 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767455005395 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 767455005396 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 767455005397 Probable Catalytic site; other site 767455005398 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 767455005399 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767455005400 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 767455005401 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 767455005402 CoA binding site [chemical binding]; other site 767455005403 active site 767455005404 trimer interface [polypeptide binding]; other site 767455005405 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 767455005406 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767455005407 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 767455005408 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767455005409 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 767455005410 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 767455005411 Bacterial sugar transferase; Region: Bac_transf; pfam02397 767455005412 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 767455005413 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 767455005414 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 767455005415 Nucleotide binding site [chemical binding]; other site 767455005416 DTAP/Switch II; other site 767455005417 Switch I; other site 767455005418 Chain length determinant protein; Region: Wzz; cl15801 767455005419 Chain length determinant protein; Region: Wzz; cl15801 767455005420 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 767455005421 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 767455005422 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 767455005423 HflX GTPase family; Region: HflX; cd01878 767455005424 G1 box; other site 767455005425 GTP/Mg2+ binding site [chemical binding]; other site 767455005426 Switch I region; other site 767455005427 G2 box; other site 767455005428 G3 box; other site 767455005429 Switch II region; other site 767455005430 G4 box; other site 767455005431 G5 box; other site 767455005432 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 767455005433 NlpC/P60 family; Region: NLPC_P60; cl17555 767455005434 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 767455005435 NlpC/P60 family; Region: NLPC_P60; pfam00877 767455005436 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 767455005437 NlpC/P60 family; Region: NLPC_P60; pfam00877 767455005438 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 767455005439 NlpC/P60 family; Region: NLPC_P60; pfam00877 767455005440 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 767455005441 NlpC/P60 family; Region: NLPC_P60; pfam00877 767455005442 (R)-2-Hydroxyglutarate Dehydrogenase and related dehydrogenases, NAD-binding and catalytic domains; Region: HGDH_like; cd12184 767455005443 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 767455005444 putative homodimer interface [polypeptide binding]; other site 767455005445 putative ligand binding site [chemical binding]; other site 767455005446 putative NAD binding site [chemical binding]; other site 767455005447 catalytic site [active] 767455005448 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 767455005449 NlpC/P60 family; Region: NLPC_P60; pfam00877 767455005450 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 767455005451 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 767455005452 catalytic site [active] 767455005453 G-X2-G-X-G-K; other site 767455005454 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 767455005455 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 767455005456 DNA binding residues [nucleotide binding] 767455005457 dimer interface [polypeptide binding]; other site 767455005458 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 767455005459 catalytic residues [active] 767455005460 catalytic nucleophile [active] 767455005461 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767455005462 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767455005463 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 767455005464 Uncharacterized conserved protein [Function unknown]; Region: COG2966 767455005465 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 767455005466 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 767455005467 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767455005468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767455005469 Walker A/P-loop; other site 767455005470 ATP binding site [chemical binding]; other site 767455005471 Q-loop/lid; other site 767455005472 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767455005473 ABC transporter signature motif; other site 767455005474 Walker B; other site 767455005475 D-loop; other site 767455005476 ABC transporter; Region: ABC_tran_2; pfam12848 767455005477 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767455005478 Predicted membrane protein (DUF2109); Region: DUF2109; cl01660 767455005479 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 767455005480 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767455005481 Probable transposase; Region: OrfB_IS605; pfam01385 767455005482 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767455005483 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767455005484 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 767455005485 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 767455005486 active site 767455005487 Zn binding site [ion binding]; other site 767455005488 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 767455005489 teramer interface [polypeptide binding]; other site 767455005490 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 767455005491 active site 767455005492 FMN binding site [chemical binding]; other site 767455005493 catalytic residues [active] 767455005494 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 767455005495 L-lactate permease; Region: Lactate_perm; cl00701 767455005496 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 767455005497 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 767455005498 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 767455005499 ABC-ATPase subunit interface; other site 767455005500 dimer interface [polypeptide binding]; other site 767455005501 putative PBP binding regions; other site 767455005502 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 767455005503 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767455005504 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767455005505 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 767455005506 active site 767455005507 motif I; other site 767455005508 motif II; other site 767455005509 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 767455005510 Nuclease-related domain; Region: NERD; pfam08378 767455005511 Initiator Replication protein; Region: Rep_3; pfam01051 767455005512 Transposase; Region: DEDD_Tnp_IS110; pfam01548 767455005513 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 767455005514 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 767455005515 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 767455005516 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 767455005517 active site 767455005518 phosphorylation site [posttranslational modification] 767455005519 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 767455005520 active site 767455005521 P-loop; other site 767455005522 phosphorylation site [posttranslational modification] 767455005523 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 767455005524 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 767455005525 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 767455005526 putative substrate binding site [chemical binding]; other site 767455005527 putative ATP binding site [chemical binding]; other site 767455005528 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 767455005529 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 767455005530 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 767455005531 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 767455005532 aspartate racemase; Region: asp_race; TIGR00035 767455005533 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 767455005534 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 767455005535 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767455005536 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767455005537 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767455005538 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767455005539 dimer interface [polypeptide binding]; other site 767455005540 phosphorylation site [posttranslational modification] 767455005541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767455005542 ATP binding site [chemical binding]; other site 767455005543 Mg2+ binding site [ion binding]; other site 767455005544 G-X-G motif; other site 767455005545 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767455005546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767455005547 active site 767455005548 phosphorylation site [posttranslational modification] 767455005549 intermolecular recognition site; other site 767455005550 dimerization interface [polypeptide binding]; other site 767455005551 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767455005552 DNA binding site [nucleotide binding] 767455005553 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767455005554 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767455005555 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 767455005556 Walker A/P-loop; other site 767455005557 ATP binding site [chemical binding]; other site 767455005558 Q-loop/lid; other site 767455005559 ABC transporter signature motif; other site 767455005560 Walker B; other site 767455005561 D-loop; other site 767455005562 H-loop/switch region; other site 767455005563 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767455005564 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767455005565 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767455005566 Walker A/P-loop; other site 767455005567 ATP binding site [chemical binding]; other site 767455005568 Q-loop/lid; other site 767455005569 ABC transporter signature motif; other site 767455005570 Walker B; other site 767455005571 D-loop; other site 767455005572 H-loop/switch region; other site 767455005573 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 767455005574 GTP-binding protein YchF; Reviewed; Region: PRK09601 767455005575 YchF GTPase; Region: YchF; cd01900 767455005576 G1 box; other site 767455005577 GTP/Mg2+ binding site [chemical binding]; other site 767455005578 Switch I region; other site 767455005579 G2 box; other site 767455005580 Switch II region; other site 767455005581 G3 box; other site 767455005582 G4 box; other site 767455005583 G5 box; other site 767455005584 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 767455005585 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 767455005586 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 767455005587 ParB-like nuclease domain; Region: ParB; smart00470 767455005588 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 767455005589 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 767455005590 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 767455005591 P-loop; other site 767455005592 Magnesium ion binding site [ion binding]; other site 767455005593 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 767455005594 ParB-like nuclease domain; Region: ParB; smart00470 767455005595 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 767455005596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767455005597 S-adenosylmethionine binding site [chemical binding]; other site 767455005598 Colicin V production protein; Region: Colicin_V; pfam02674 767455005599 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 767455005600 ApbE family; Region: ApbE; pfam02424 767455005601 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 767455005602 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 767455005603 Predicted flavoprotein [General function prediction only]; Region: COG0431 767455005604 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767455005605 Predicted flavoprotein [General function prediction only]; Region: COG0431 767455005606 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767455005607 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767455005608 WHG domain; Region: WHG; pfam13305 767455005609 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 767455005610 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cd04761 767455005611 DNA binding residues [nucleotide binding] 767455005612 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 767455005613 catalytic residues [active] 767455005614 catalytic nucleophile [active] 767455005615 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767455005616 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767455005617 Peptidase family C69; Region: Peptidase_C69; pfam03577 767455005618 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767455005619 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 767455005620 Walker A/P-loop; other site 767455005621 ATP binding site [chemical binding]; other site 767455005622 Q-loop/lid; other site 767455005623 ABC transporter signature motif; other site 767455005624 Walker B; other site 767455005625 D-loop; other site 767455005626 H-loop/switch region; other site 767455005627 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 767455005628 HPr interaction site; other site 767455005629 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767455005630 active site 767455005631 phosphorylation site [posttranslational modification] 767455005632 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 767455005633 Predicted transcriptional regulator [Transcription]; Region: COG2378 767455005634 WYL domain; Region: WYL; pfam13280 767455005635 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767455005636 Probable transposase; Region: OrfB_IS605; pfam01385 767455005637 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767455005638 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767455005639 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767455005640 Walker A/P-loop; other site 767455005641 ATP binding site [chemical binding]; other site 767455005642 Q-loop/lid; other site 767455005643 ABC transporter signature motif; other site 767455005644 Walker B; other site 767455005645 D-loop; other site 767455005646 H-loop/switch region; other site 767455005647 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 767455005648 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767455005649 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 767455005650 FAD binding domain; Region: FAD_binding_4; pfam01565 767455005651 hypothetical protein; Validated; Region: PRK02101 767455005652 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 767455005653 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 767455005654 Rib/alpha-like repeat; Region: Rib; cl07159 767455005655 Rib/alpha-like repeat; Region: Rib; cl07159 767455005656 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 767455005657 dimer interface [polypeptide binding]; other site 767455005658 FMN binding site [chemical binding]; other site 767455005659 Peptidase family M1; Region: Peptidase_M1; pfam01433 767455005660 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 767455005661 Zn binding site [ion binding]; other site 767455005662 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 767455005663 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767455005664 putative transposase OrfB; Reviewed; Region: PHA02517 767455005665 HTH-like domain; Region: HTH_21; pfam13276 767455005666 Integrase core domain; Region: rve; pfam00665 767455005667 Integrase core domain; Region: rve_2; pfam13333 767455005668 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 767455005669 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 767455005670 Peptidase family C69; Region: Peptidase_C69; cl17793 767455005671 Peptidase family C69; Region: Peptidase_C69; cl17793 767455005672 Peptidase family C69; Region: Peptidase_C69; cl17793 767455005673 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 767455005674 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 767455005675 transmembrane helices; other site 767455005676 fumarate hydratase; Reviewed; Region: fumC; PRK00485 767455005677 Class II fumarases; Region: Fumarase_classII; cd01362 767455005678 active site 767455005679 tetramer interface [polypeptide binding]; other site 767455005680 RRXRR protein; Region: RRXRR; pfam14239 767455005681 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 767455005682 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 767455005683 active site 767455005684 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 767455005685 putative ADP-ribose binding site [chemical binding]; other site 767455005686 putative active site [active] 767455005687 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 767455005688 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 767455005689 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 767455005690 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 767455005691 glycerol kinase; Provisional; Region: glpK; PRK00047 767455005692 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 767455005693 N- and C-terminal domain interface [polypeptide binding]; other site 767455005694 active site 767455005695 MgATP binding site [chemical binding]; other site 767455005696 catalytic site [active] 767455005697 metal binding site [ion binding]; metal-binding site 767455005698 glycerol binding site [chemical binding]; other site 767455005699 homotetramer interface [polypeptide binding]; other site 767455005700 homodimer interface [polypeptide binding]; other site 767455005701 FBP binding site [chemical binding]; other site 767455005702 protein IIAGlc interface [polypeptide binding]; other site 767455005703 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 767455005704 catalytic triad [active] 767455005705 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767455005706 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 767455005707 Walker A motif; other site 767455005708 ATP binding site [chemical binding]; other site 767455005709 Walker B motif; other site 767455005710 arginine finger; other site 767455005711 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767455005712 Walker A motif; other site 767455005713 ATP binding site [chemical binding]; other site 767455005714 Walker B motif; other site 767455005715 arginine finger; other site 767455005716 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 767455005717 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 767455005718 DNA-binding site [nucleotide binding]; DNA binding site 767455005719 RNA-binding motif; other site 767455005720 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 767455005721 EamA-like transporter family; Region: EamA; pfam00892 767455005722 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 767455005723 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 767455005724 catalytic triad [active] 767455005725 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 767455005726 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767455005727 active site 767455005728 motif I; other site 767455005729 motif II; other site 767455005730 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767455005731 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 767455005732 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 767455005733 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 767455005734 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767455005735 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767455005736 dimerization interface [polypeptide binding]; other site 767455005737 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 767455005738 homopentamer interface [polypeptide binding]; other site 767455005739 active site 767455005740 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 767455005741 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 767455005742 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 767455005743 dimerization interface [polypeptide binding]; other site 767455005744 active site 767455005745 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 767455005746 Lumazine binding domain; Region: Lum_binding; pfam00677 767455005747 Lumazine binding domain; Region: Lum_binding; pfam00677 767455005748 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767455005749 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767455005750 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767455005751 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767455005752 Walker A/P-loop; other site 767455005753 ATP binding site [chemical binding]; other site 767455005754 Q-loop/lid; other site 767455005755 ABC transporter signature motif; other site 767455005756 Walker B; other site 767455005757 D-loop; other site 767455005758 H-loop/switch region; other site 767455005759 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 767455005760 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 767455005761 FtsX-like permease family; Region: FtsX; pfam02687 767455005762 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 767455005763 DltD N-terminal region; Region: DltD_N; pfam04915 767455005764 DltD central region; Region: DltD_M; pfam04918 767455005765 DltD C-terminal region; Region: DltD_C; pfam04914 767455005766 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 767455005767 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 767455005768 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 767455005769 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 767455005770 acyl-activating enzyme (AAE) consensus motif; other site 767455005771 AMP binding site [chemical binding]; other site 767455005772 Transposase; Region: DEDD_Tnp_IS110; pfam01548 767455005773 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 767455005774 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 767455005775 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767455005776 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767455005777 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767455005778 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 767455005779 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767455005780 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767455005781 Transposase; Region: DEDD_Tnp_IS110; pfam01548 767455005782 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 767455005783 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 767455005784 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767455005785 MULE transposase domain; Region: MULE; pfam10551 767455005786 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 767455005787 active site 767455005788 catalytic site [active] 767455005789 substrate binding site [chemical binding]; other site 767455005790 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 767455005791 BRCA1 C Terminus (BRCT) domain; Region: BRCT; pfam00533 767455005792 Dimer interface [polypeptide binding]; other site 767455005793 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 767455005794 PLD-like domain; Region: PLDc_2; pfam13091 767455005795 putative active site [active] 767455005796 catalytic site [active] 767455005797 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 767455005798 helicase superfamily c-terminal domain; Region: HELICc; smart00490 767455005799 ATP-binding site [chemical binding]; other site 767455005800 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 767455005801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 767455005802 ATP binding site [chemical binding]; other site 767455005803 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 767455005804 putative Mg++ binding site [ion binding]; other site 767455005805 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 767455005806 DNA methylase; Region: N6_N4_Mtase; cl17433 767455005807 DNA methylase; Region: N6_N4_Mtase; pfam01555 767455005808 DEAD-like helicases superfamily; Region: DEXDc; smart00487 767455005809 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767455005810 ATP binding site [chemical binding]; other site 767455005811 putative Mg++ binding site [ion binding]; other site 767455005812 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767455005813 nucleotide binding region [chemical binding]; other site 767455005814 ATP-binding site [chemical binding]; other site 767455005815 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 767455005816 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 767455005817 DNA binding site [nucleotide binding] 767455005818 substrate interaction site [chemical binding]; other site 767455005819 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 767455005820 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 767455005821 Transposase; Region: DEDD_Tnp_IS110; pfam01548 767455005822 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 767455005823 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 767455005824 FOG: CBS domain [General function prediction only]; Region: COG0517 767455005825 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 767455005826 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 767455005827 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767455005828 Soluble P-type ATPase [General function prediction only]; Region: COG4087 767455005829 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 767455005830 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 767455005831 CAAX protease self-immunity; Region: Abi; pfam02517 767455005832 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 767455005833 putative active site [active] 767455005834 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 767455005835 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 767455005836 ligand binding site [chemical binding]; other site 767455005837 Catalytic domain of Protein Kinases; Region: PKc; cd00180 767455005838 active site 767455005839 ATP binding site [chemical binding]; other site 767455005840 substrate binding site [chemical binding]; other site 767455005841 activation loop (A-loop); other site 767455005842 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 767455005843 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 767455005844 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 767455005845 ligand binding site [chemical binding]; other site 767455005846 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 767455005847 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 767455005848 ligand binding site [chemical binding]; other site 767455005849 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 767455005850 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 767455005851 Walker A/P-loop; other site 767455005852 ATP binding site [chemical binding]; other site 767455005853 Q-loop/lid; other site 767455005854 ABC transporter signature motif; other site 767455005855 Walker B; other site 767455005856 D-loop; other site 767455005857 H-loop/switch region; other site 767455005858 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 767455005859 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 767455005860 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 767455005861 TM-ABC transporter signature motif; other site 767455005862 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 767455005863 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 767455005864 TM-ABC transporter signature motif; other site 767455005865 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 767455005866 H+ Antiporter protein; Region: 2A0121; TIGR00900 767455005867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767455005868 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767455005869 non-specific DNA binding site [nucleotide binding]; other site 767455005870 salt bridge; other site 767455005871 sequence-specific DNA binding site [nucleotide binding]; other site 767455005872 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 767455005873 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 767455005874 active site 767455005875 catalytic tetrad [active] 767455005876 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 767455005877 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 767455005878 active site 767455005879 trimer interface [polypeptide binding]; other site 767455005880 allosteric site; other site 767455005881 active site lid [active] 767455005882 hexamer (dimer of trimers) interface [polypeptide binding]; other site 767455005883 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 767455005884 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767455005885 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767455005886 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 767455005887 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 767455005888 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 767455005889 Magnesium ion binding site [ion binding]; other site 767455005890 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767455005891 active site 767455005892 Int/Topo IB signature motif; other site 767455005893 DNA binding site [nucleotide binding] 767455005894 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 767455005895 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 767455005896 dimerization interface [polypeptide binding]; other site 767455005897 DPS ferroxidase diiron center [ion binding]; other site 767455005898 ion pore; other site 767455005899 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767455005900 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 767455005901 Walker A/P-loop; other site 767455005902 ATP binding site [chemical binding]; other site 767455005903 Q-loop/lid; other site 767455005904 ABC transporter signature motif; other site 767455005905 Walker B; other site 767455005906 D-loop; other site 767455005907 H-loop/switch region; other site 767455005908 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 767455005909 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 767455005910 Substrate-binding site [chemical binding]; other site 767455005911 Substrate specificity [chemical binding]; other site 767455005912 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 767455005913 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 767455005914 Substrate-binding site [chemical binding]; other site 767455005915 Substrate specificity [chemical binding]; other site 767455005916 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767455005917 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767455005918 substrate binding pocket [chemical binding]; other site 767455005919 membrane-bound complex binding site; other site 767455005920 hinge residues; other site 767455005921 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 767455005922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767455005923 dimer interface [polypeptide binding]; other site 767455005924 conserved gate region; other site 767455005925 putative PBP binding loops; other site 767455005926 ABC-ATPase subunit interface; other site 767455005927 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 767455005928 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 767455005929 Walker A/P-loop; other site 767455005930 ATP binding site [chemical binding]; other site 767455005931 Q-loop/lid; other site 767455005932 ABC transporter signature motif; other site 767455005933 Walker B; other site 767455005934 D-loop; other site 767455005935 H-loop/switch region; other site 767455005936 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 767455005937 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 767455005938 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 767455005939 Cl- selectivity filter; other site 767455005940 Cl- binding residues [ion binding]; other site 767455005941 pore gating glutamate residue; other site 767455005942 dimer interface [polypeptide binding]; other site 767455005943 H+/Cl- coupling transport residue; other site 767455005944 TrkA-C domain; Region: TrkA_C; pfam02080 767455005945 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767455005946 Walker B; other site 767455005947 D-loop; other site 767455005948 H-loop/switch region; other site 767455005949 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 767455005950 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 767455005951 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 767455005952 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 767455005953 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 767455005954 PYR/PP interface [polypeptide binding]; other site 767455005955 dimer interface [polypeptide binding]; other site 767455005956 tetramer interface [polypeptide binding]; other site 767455005957 TPP binding site [chemical binding]; other site 767455005958 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 767455005959 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 767455005960 TPP-binding site [chemical binding]; other site 767455005961 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 767455005962 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 767455005963 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 767455005964 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 767455005965 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 767455005966 trmE is a tRNA modification GTPase; Region: trmE; cd04164 767455005967 G1 box; other site 767455005968 GTP/Mg2+ binding site [chemical binding]; other site 767455005969 Switch I region; other site 767455005970 G2 box; other site 767455005971 Switch II region; other site 767455005972 G3 box; other site 767455005973 G4 box; other site 767455005974 G5 box; other site 767455005975 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 767455005976 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 767455005977 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 767455005978 ribonuclease P; Reviewed; Region: rnpA; PRK00499 767455005979 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 767455005980 CHC2 zinc finger; Region: zf-CHC2; cl17510 767455005981 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 767455005982 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 767455005983 active site 767455005984 metal binding site [ion binding]; metal-binding site 767455005985 interdomain interaction site; other site 767455005986 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 767455005987 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 767455005988 Walker A motif; other site 767455005989 ATP binding site [chemical binding]; other site 767455005990 Walker B motif; other site