-- dump date 20140619_123339 -- class Genbank::misc_feature -- table misc_feature_note -- id note 712938000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 712938000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 712938000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712938000004 Walker A motif; other site 712938000005 ATP binding site [chemical binding]; other site 712938000006 Walker B motif; other site 712938000007 arginine finger; other site 712938000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 712938000009 DnaA box-binding interface [nucleotide binding]; other site 712938000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 712938000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 712938000012 putative DNA binding surface [nucleotide binding]; other site 712938000013 dimer interface [polypeptide binding]; other site 712938000014 beta-clamp/clamp loader binding surface; other site 712938000015 beta-clamp/translesion DNA polymerase binding surface; other site 712938000016 recombination protein F; Reviewed; Region: recF; PRK00064 712938000017 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 712938000018 Walker A/P-loop; other site 712938000019 ATP binding site [chemical binding]; other site 712938000020 Q-loop/lid; other site 712938000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712938000022 ABC transporter signature motif; other site 712938000023 Walker B; other site 712938000024 D-loop; other site 712938000025 H-loop/switch region; other site 712938000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 712938000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 712938000028 ATP binding site [chemical binding]; other site 712938000029 Mg2+ binding site [ion binding]; other site 712938000030 G-X-G motif; other site 712938000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 712938000032 anchoring element; other site 712938000033 dimer interface [polypeptide binding]; other site 712938000034 ATP binding site [chemical binding]; other site 712938000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 712938000036 active site 712938000037 putative metal-binding site [ion binding]; other site 712938000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 712938000039 DNA gyrase subunit A; Validated; Region: PRK05560 712938000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 712938000041 CAP-like domain; other site 712938000042 active site 712938000043 primary dimer interface [polypeptide binding]; other site 712938000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 712938000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 712938000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 712938000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 712938000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 712938000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 712938000050 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 712938000051 DHH family; Region: DHH; pfam01368 712938000052 DHHA1 domain; Region: DHHA1; pfam02272 712938000053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938000054 Major Facilitator Superfamily; Region: MFS_1; pfam07690 712938000055 putative substrate translocation pore; other site 712938000056 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 712938000057 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 712938000058 dimerization interface [polypeptide binding]; other site 712938000059 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 712938000060 putative active site [active] 712938000061 heme pocket [chemical binding]; other site 712938000062 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 712938000063 dimer interface [polypeptide binding]; other site 712938000064 phosphorylation site [posttranslational modification] 712938000065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 712938000066 ATP binding site [chemical binding]; other site 712938000067 Mg2+ binding site [ion binding]; other site 712938000068 G-X-G motif; other site 712938000069 YycH protein; Region: YycH; pfam07435 712938000070 YycH protein; Region: YycI; pfam09648 712938000071 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 712938000072 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 712938000073 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 712938000074 Transcriptional regulator; Region: Rrf2; pfam02082 712938000075 Transcriptional regulators [Transcription]; Region: PurR; COG1609 712938000076 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 712938000077 DNA binding site [nucleotide binding] 712938000078 domain linker motif; other site 712938000079 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 712938000080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938000081 putative substrate translocation pore; other site 712938000082 Major Facilitator Superfamily; Region: MFS_1; pfam07690 712938000083 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 712938000084 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 712938000085 active site 712938000086 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 712938000087 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 712938000088 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 712938000089 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 712938000090 homodimer interface [polypeptide binding]; other site 712938000091 ligand binding site [chemical binding]; other site 712938000092 NAD binding site [chemical binding]; other site 712938000093 catalytic site [active] 712938000094 aromatic amino acid aminotransferase; Validated; Region: PRK07309 712938000095 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 712938000096 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712938000097 homodimer interface [polypeptide binding]; other site 712938000098 catalytic residue [active] 712938000099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712938000100 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 712938000101 Walker A motif; other site 712938000102 ATP binding site [chemical binding]; other site 712938000103 Walker B motif; other site 712938000104 arginine finger; other site 712938000105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712938000106 Walker A motif; other site 712938000107 ATP binding site [chemical binding]; other site 712938000108 Walker B motif; other site 712938000109 arginine finger; other site 712938000110 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 712938000111 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 712938000112 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 712938000113 PLD-like domain; Region: PLDc_2; pfam13091 712938000114 putative active site [active] 712938000115 catalytic site [active] 712938000116 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 712938000117 Family description; Region: UvrD_C_2; pfam13538 712938000118 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 712938000119 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 712938000120 catalytic tetrad [active] 712938000121 Aldo/keto reductases, related to diketogulonate reductase [General function prediction only]; Region: ARA1; COG0656 712938000122 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 712938000123 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 712938000124 putative active site [active] 712938000125 catalytic site [active] 712938000126 putative metal binding site [ion binding]; other site 712938000127 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 712938000128 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 712938000129 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 712938000130 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 712938000131 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 712938000132 GDP-binding site [chemical binding]; other site 712938000133 ACT binding site; other site 712938000134 IMP binding site; other site 712938000135 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 712938000136 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 712938000137 NAD(P) binding site [chemical binding]; other site 712938000138 catalytic residues [active] 712938000139 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 712938000140 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712938000141 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 712938000142 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 712938000143 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 712938000144 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 712938000145 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 712938000146 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 712938000147 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 712938000148 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 712938000149 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 712938000150 Walker A/P-loop; other site 712938000151 ATP binding site [chemical binding]; other site 712938000152 Q-loop/lid; other site 712938000153 ABC transporter signature motif; other site 712938000154 Walker B; other site 712938000155 D-loop; other site 712938000156 H-loop/switch region; other site 712938000157 NIL domain; Region: NIL; pfam09383 712938000158 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 712938000159 metal binding site [ion binding]; metal-binding site 712938000160 dimer interface [polypeptide binding]; other site 712938000161 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 712938000162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 712938000163 S-adenosylmethionine binding site [chemical binding]; other site 712938000164 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 712938000165 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 712938000166 Probable transposase; Region: OrfB_IS605; pfam01385 712938000167 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 712938000168 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 712938000169 DltD N-terminal region; Region: DltD_N; pfam04915 712938000170 DltD central region; Region: DltD_M; pfam04918 712938000171 DltD C-terminal region; Region: DltD_C; pfam04914 712938000172 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 712938000173 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 712938000174 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 712938000175 acyl-activating enzyme (AAE) consensus motif; other site 712938000176 AMP binding site [chemical binding]; other site 712938000177 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 712938000178 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 712938000179 active site 712938000180 metal binding site [ion binding]; metal-binding site 712938000181 DNA binding site [nucleotide binding] 712938000182 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 712938000183 seryl-tRNA synthetase; Provisional; Region: PRK05431 712938000184 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 712938000185 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 712938000186 dimer interface [polypeptide binding]; other site 712938000187 active site 712938000188 motif 1; other site 712938000189 motif 2; other site 712938000190 motif 3; other site 712938000191 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 712938000192 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 712938000193 active site 712938000194 HIGH motif; other site 712938000195 dimer interface [polypeptide binding]; other site 712938000196 KMSKS motif; other site 712938000197 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 712938000198 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 712938000199 active site 712938000200 HIGH motif; other site 712938000201 dimer interface [polypeptide binding]; other site 712938000202 KMSKS motif; other site 712938000203 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 712938000204 RNA binding surface [nucleotide binding]; other site 712938000205 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 712938000206 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 712938000207 substrate binding pocket [chemical binding]; other site 712938000208 membrane-bound complex binding site; other site 712938000209 hinge residues; other site 712938000210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 712938000211 dimer interface [polypeptide binding]; other site 712938000212 conserved gate region; other site 712938000213 putative PBP binding loops; other site 712938000214 ABC-ATPase subunit interface; other site 712938000215 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 712938000216 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 712938000217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 712938000218 Probable transposase; Region: OrfB_IS605; pfam01385 712938000219 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 712938000220 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 712938000221 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 712938000222 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 712938000223 active site 712938000224 tetramer interface [polypeptide binding]; other site 712938000225 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 712938000226 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 712938000227 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 712938000228 ParB-like nuclease domain; Region: ParBc; pfam02195 712938000229 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 712938000230 ParB-like nuclease domain; Region: ParB; smart00470 712938000231 KorB domain; Region: KorB; pfam08535 712938000232 GTP-binding protein YchF; Reviewed; Region: PRK09601 712938000233 YchF GTPase; Region: YchF; cd01900 712938000234 G1 box; other site 712938000235 GTP/Mg2+ binding site [chemical binding]; other site 712938000236 Switch I region; other site 712938000237 G2 box; other site 712938000238 Switch II region; other site 712938000239 G3 box; other site 712938000240 G4 box; other site 712938000241 G5 box; other site 712938000242 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 712938000243 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 712938000244 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 712938000245 active site 712938000246 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938000247 MULE transposase domain; Region: MULE; pfam10551 712938000248 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 712938000249 Chain length determinant protein; Region: Wzz; cl15801 712938000250 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 712938000251 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 712938000252 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 712938000253 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 712938000254 active site 712938000255 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 712938000256 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 712938000257 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 712938000258 active site 712938000259 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 712938000260 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 712938000261 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 712938000262 active site 712938000263 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 712938000264 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 712938000265 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 712938000266 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 712938000267 substrate binding site; other site 712938000268 tetramer interface; other site 712938000269 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 712938000270 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 712938000271 NAD binding site [chemical binding]; other site 712938000272 substrate binding site [chemical binding]; other site 712938000273 homodimer interface [polypeptide binding]; other site 712938000274 active site 712938000275 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 712938000276 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 712938000277 NADP binding site [chemical binding]; other site 712938000278 active site 712938000279 putative substrate binding site [chemical binding]; other site 712938000280 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938000281 MULE transposase domain; Region: MULE; pfam10551 712938000282 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712938000283 AAA domain; Region: AAA_21; pfam13304 712938000284 Walker A/P-loop; other site 712938000285 ATP binding site [chemical binding]; other site 712938000286 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 712938000287 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 712938000288 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 712938000289 dimer interface [polypeptide binding]; other site 712938000290 phosphorylation site [posttranslational modification] 712938000291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 712938000292 ATP binding site [chemical binding]; other site 712938000293 Mg2+ binding site [ion binding]; other site 712938000294 G-X-G motif; other site 712938000295 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 712938000296 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 712938000297 AzlC protein; Region: AzlC; pfam03591 712938000298 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 712938000299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 712938000300 S-adenosylmethionine binding site [chemical binding]; other site 712938000301 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 712938000302 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 712938000303 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 712938000304 ATP-grasp domain; Region: ATP-grasp; pfam02222 712938000305 adenylosuccinate lyase; Provisional; Region: PRK07492 712938000306 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 712938000307 tetramer interface [polypeptide binding]; other site 712938000308 active site 712938000309 Predicted membrane protein [Function unknown]; Region: COG4640 712938000310 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 712938000311 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 712938000312 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 712938000313 active site 712938000314 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 712938000315 active site 712938000316 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 712938000317 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 712938000318 dimerization interface [polypeptide binding]; other site 712938000319 putative ATP binding site [chemical binding]; other site 712938000320 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 712938000321 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 712938000322 purine monophosphate binding site [chemical binding]; other site 712938000323 dimer interface [polypeptide binding]; other site 712938000324 putative catalytic residues [active] 712938000325 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 712938000326 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 712938000327 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 712938000328 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 712938000329 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 712938000330 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 712938000331 Probable transposase; Region: OrfB_IS605; pfam01385 712938000332 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 712938000333 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 712938000334 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 712938000335 homodimer interface [polypeptide binding]; other site 712938000336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712938000337 catalytic residue [active] 712938000338 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 712938000339 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 712938000340 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 712938000341 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 712938000342 Helix-turn-helix domain; Region: HTH_38; pfam13936 712938000343 Integrase core domain; Region: rve; pfam00665 712938000344 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 712938000345 heme-binding site [chemical binding]; other site 712938000346 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 712938000347 heme-binding site [chemical binding]; other site 712938000348 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 712938000349 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 712938000350 intersubunit interface [polypeptide binding]; other site 712938000351 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 712938000352 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 712938000353 Walker A/P-loop; other site 712938000354 ATP binding site [chemical binding]; other site 712938000355 Q-loop/lid; other site 712938000356 ABC transporter signature motif; other site 712938000357 Walker B; other site 712938000358 D-loop; other site 712938000359 H-loop/switch region; other site 712938000360 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 712938000361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938000362 putative substrate translocation pore; other site 712938000363 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 712938000364 active site 712938000365 putative catalytic site [active] 712938000366 DNA binding site [nucleotide binding] 712938000367 putative phosphate binding site [ion binding]; other site 712938000368 metal binding site A [ion binding]; metal-binding site 712938000369 AP binding site [nucleotide binding]; other site 712938000370 metal binding site B [ion binding]; metal-binding site 712938000371 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 712938000372 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 712938000373 putative ligand binding site [chemical binding]; other site 712938000374 putative NAD binding site [chemical binding]; other site 712938000375 catalytic site [active] 712938000376 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 712938000377 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 712938000378 catalytic residue [active] 712938000379 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 712938000380 active site 712938000381 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 712938000382 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 712938000383 active site 712938000384 metal binding site [ion binding]; metal-binding site 712938000385 dimer interface [polypeptide binding]; other site 712938000386 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 712938000387 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 712938000388 active site 712938000389 tetramer interface [polypeptide binding]; other site 712938000390 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 712938000391 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 712938000392 Zn binding site [ion binding]; other site 712938000393 Transcriptional regulator [Transcription]; Region: LysR; COG0583 712938000394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 712938000395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 712938000396 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 712938000397 Probable transposase; Region: OrfB_IS605; pfam01385 712938000398 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 712938000399 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 712938000400 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 712938000401 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 712938000402 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 712938000403 Part of AAA domain; Region: AAA_19; pfam13245 712938000404 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 712938000405 helix swapped region; other site 712938000406 homodimer interface [polypeptide binding]; other site 712938000407 NADH/NADPH cofactor binding site [chemical binding]; other site 712938000408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938000409 Major Facilitator Superfamily; Region: MFS_1; pfam07690 712938000410 putative substrate translocation pore; other site 712938000411 Protein of unknown function DUF72; Region: DUF72; pfam01904 712938000412 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 712938000413 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 712938000414 HIGH motif; other site 712938000415 active site 712938000416 KMSKS motif; other site 712938000417 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 712938000418 tRNA binding surface [nucleotide binding]; other site 712938000419 anticodon binding site; other site 712938000420 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 712938000421 dimer interface [polypeptide binding]; other site 712938000422 putative tRNA-binding site [nucleotide binding]; other site 712938000423 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 712938000424 active site 712938000425 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 712938000426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 712938000427 S-adenosylmethionine binding site [chemical binding]; other site 712938000428 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 712938000429 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 712938000430 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 712938000431 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 712938000432 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 712938000433 metal binding site [ion binding]; metal-binding site 712938000434 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 712938000435 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 712938000436 ABC-ATPase subunit interface; other site 712938000437 dimer interface [polypeptide binding]; other site 712938000438 putative PBP binding regions; other site 712938000439 pur operon repressor; Provisional; Region: PRK09213 712938000440 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 712938000441 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 712938000442 active site 712938000443 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 712938000444 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 712938000445 Substrate binding site; other site 712938000446 Mg++ binding site; other site 712938000447 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 712938000448 active site 712938000449 substrate binding site [chemical binding]; other site 712938000450 CoA binding site [chemical binding]; other site 712938000451 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 712938000452 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 712938000453 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 712938000454 active site 712938000455 sugar phosphate phosphatase; Provisional; Region: PRK10513 712938000456 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 712938000457 active site 712938000458 motif I; other site 712938000459 motif II; other site 712938000460 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 712938000461 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 712938000462 Zn2+ binding site [ion binding]; other site 712938000463 Mg2+ binding site [ion binding]; other site 712938000464 CTP synthetase; Validated; Region: pyrG; PRK05380 712938000465 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 712938000466 Catalytic site [active] 712938000467 active site 712938000468 UTP binding site [chemical binding]; other site 712938000469 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 712938000470 active site 712938000471 putative oxyanion hole; other site 712938000472 catalytic triad [active] 712938000473 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 712938000474 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 712938000475 hinge; other site 712938000476 active site 712938000477 heat shock protein HtpX; Provisional; Region: PRK04897 712938000478 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 712938000479 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 712938000480 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 712938000481 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 712938000482 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 712938000483 DEAD-like helicases superfamily; Region: DEXDc; smart00487 712938000484 ATP binding site [chemical binding]; other site 712938000485 Mg++ binding site [ion binding]; other site 712938000486 motif III; other site 712938000487 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 712938000488 alanine racemase; Reviewed; Region: alr; PRK00053 712938000489 active site 712938000490 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 712938000491 dimer interface [polypeptide binding]; other site 712938000492 substrate binding site [chemical binding]; other site 712938000493 catalytic residues [active] 712938000494 transcription-repair coupling factor (mfd); Region: mfd; TIGR00580 712938000495 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 712938000496 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 712938000497 ATP binding site [chemical binding]; other site 712938000498 putative Mg++ binding site [ion binding]; other site 712938000499 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 712938000500 nucleotide binding region [chemical binding]; other site 712938000501 ATP-binding site [chemical binding]; other site 712938000502 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 712938000503 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 712938000504 Septum formation initiator; Region: DivIC; pfam04977 712938000505 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 712938000506 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 712938000507 Ligand Binding Site [chemical binding]; other site 712938000508 TilS substrate C-terminal domain; Region: TilS_C; smart00977 712938000509 FtsH Extracellular; Region: FtsH_ext; pfam06480 712938000510 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 712938000511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712938000512 Walker A motif; other site 712938000513 ATP binding site [chemical binding]; other site 712938000514 Walker B motif; other site 712938000515 arginine finger; other site 712938000516 Peptidase family M41; Region: Peptidase_M41; pfam01434 712938000517 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 712938000518 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 712938000519 dimerization interface [polypeptide binding]; other site 712938000520 domain crossover interface; other site 712938000521 redox-dependent activation switch; other site 712938000522 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 712938000523 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 712938000524 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 712938000525 dimer interface [polypeptide binding]; other site 712938000526 putative anticodon binding site; other site 712938000527 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 712938000528 motif 1; other site 712938000529 active site 712938000530 motif 2; other site 712938000531 motif 3; other site 712938000532 D5 N terminal like; Region: D5_N; smart00885 712938000533 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 712938000534 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 712938000535 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 712938000536 polymerase nucleotide-binding site; other site 712938000537 DNA-binding residues [nucleotide binding]; DNA binding site 712938000538 nucleotide binding site [chemical binding]; other site 712938000539 primase nucleotide-binding site [nucleotide binding]; other site 712938000540 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 712938000541 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 712938000542 non-specific DNA binding site [nucleotide binding]; other site 712938000543 salt bridge; other site 712938000544 sequence-specific DNA binding site [nucleotide binding]; other site 712938000545 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 712938000546 Int/Topo IB signature motif; other site 712938000547 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 712938000548 tetramer (dimer of dimers) interface [polypeptide binding]; other site 712938000549 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 712938000550 NAD binding site [chemical binding]; other site 712938000551 dimer interface [polypeptide binding]; other site 712938000552 substrate binding site [chemical binding]; other site 712938000553 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 712938000554 metabolite-proton symporter; Region: 2A0106; TIGR00883 712938000555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938000556 putative substrate translocation pore; other site 712938000557 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 712938000558 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 712938000559 Probable transposase; Region: OrfB_IS605; pfam01385 712938000560 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 712938000561 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 712938000562 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 712938000563 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 712938000564 POT family; Region: PTR2; cl17359 712938000565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938000566 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 712938000567 putative phosphoesterase; Region: acc_ester; TIGR03729 712938000568 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 712938000569 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 712938000570 active site 712938000571 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 712938000572 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 712938000573 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 712938000574 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 712938000575 RNA binding site [nucleotide binding]; other site 712938000576 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 712938000577 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 712938000578 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 712938000579 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 712938000580 Predicted permeases [General function prediction only]; Region: COG0679 712938000581 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 712938000582 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 712938000583 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 712938000584 trimer interface [polypeptide binding]; other site 712938000585 active site 712938000586 G bulge; other site 712938000587 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 712938000588 tetramer (dimer of dimers) interface [polypeptide binding]; other site 712938000589 active site 712938000590 dimer interface [polypeptide binding]; other site 712938000591 DNA repair protein RadA; Provisional; Region: PRK11823 712938000592 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 712938000593 Walker A motif/ATP binding site; other site 712938000594 ATP binding site [chemical binding]; other site 712938000595 Walker B motif; other site 712938000596 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 712938000597 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 712938000598 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 712938000599 putative active site [active] 712938000600 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 712938000601 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 712938000602 active site 712938000603 HIGH motif; other site 712938000604 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 712938000605 active site 712938000606 KMSKS motif; other site 712938000607 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 712938000608 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 712938000609 active site 712938000610 HIGH motif; other site 712938000611 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 712938000612 KMSKS motif; other site 712938000613 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 712938000614 tRNA binding surface [nucleotide binding]; other site 712938000615 anticodon binding site; other site 712938000616 Amino acid permease; Region: AA_permease_2; pfam13520 712938000617 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 712938000618 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 712938000619 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 712938000620 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 712938000621 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 712938000622 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 712938000623 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 712938000624 Walker A/P-loop; other site 712938000625 ATP binding site [chemical binding]; other site 712938000626 Q-loop/lid; other site 712938000627 ABC transporter signature motif; other site 712938000628 Walker B; other site 712938000629 D-loop; other site 712938000630 H-loop/switch region; other site 712938000631 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 712938000632 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 712938000633 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 712938000634 Walker A/P-loop; other site 712938000635 ATP binding site [chemical binding]; other site 712938000636 Q-loop/lid; other site 712938000637 ABC transporter signature motif; other site 712938000638 Walker B; other site 712938000639 D-loop; other site 712938000640 H-loop/switch region; other site 712938000641 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 712938000642 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 712938000643 putative catalytic cysteine [active] 712938000644 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 712938000645 putative active site [active] 712938000646 metal binding site [ion binding]; metal-binding site 712938000647 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 712938000648 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 712938000649 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 712938000650 dimer interface [polypeptide binding]; other site 712938000651 putative radical transfer pathway; other site 712938000652 diiron center [ion binding]; other site 712938000653 tyrosyl radical; other site 712938000654 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 712938000655 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 712938000656 Class I ribonucleotide reductase; Region: RNR_I; cd01679 712938000657 active site 712938000658 dimer interface [polypeptide binding]; other site 712938000659 catalytic residues [active] 712938000660 effector binding site; other site 712938000661 R2 peptide binding site; other site 712938000662 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 712938000663 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712938000664 Walker A motif; other site 712938000665 ATP binding site [chemical binding]; other site 712938000666 Walker B motif; other site 712938000667 arginine finger; other site 712938000668 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 712938000669 hypothetical protein; Validated; Region: PRK00153 712938000670 Predicted methyltransferases [General function prediction only]; Region: COG0313 712938000671 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 712938000672 putative SAM binding site [chemical binding]; other site 712938000673 putative homodimer interface [polypeptide binding]; other site 712938000674 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 712938000675 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 712938000676 active site 712938000677 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 712938000678 active site 712938000679 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 712938000680 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 712938000681 polyphosphate kinase; Provisional; Region: PRK05443 712938000682 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 712938000683 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 712938000684 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 712938000685 putative domain interface [polypeptide binding]; other site 712938000686 putative active site [active] 712938000687 catalytic site [active] 712938000688 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 712938000689 putative domain interface [polypeptide binding]; other site 712938000690 putative active site [active] 712938000691 catalytic site [active] 712938000692 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 712938000693 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 712938000694 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 712938000695 NAD binding site [chemical binding]; other site 712938000696 homodimer interface [polypeptide binding]; other site 712938000697 active site 712938000698 substrate binding site [chemical binding]; other site 712938000699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 712938000700 Response regulator receiver domain; Region: Response_reg; pfam00072 712938000701 active site 712938000702 phosphorylation site [posttranslational modification] 712938000703 intermolecular recognition site; other site 712938000704 dimerization interface [polypeptide binding]; other site 712938000705 YcbB domain; Region: YcbB; pfam08664 712938000706 ornithine carbamoyltransferase; Provisional; Region: PRK04284 712938000707 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 712938000708 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 712938000709 carbamate kinase; Reviewed; Region: PRK12686 712938000710 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 712938000711 putative substrate binding site [chemical binding]; other site 712938000712 nucleotide binding site [chemical binding]; other site 712938000713 nucleotide binding site [chemical binding]; other site 712938000714 homodimer interface [polypeptide binding]; other site 712938000715 arginine deiminase; Provisional; Region: PRK01388 712938000716 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 712938000717 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 712938000718 substrate binding site [chemical binding]; other site 712938000719 THF binding site; other site 712938000720 zinc-binding site [ion binding]; other site 712938000721 transaminase; Validated; Region: PRK07324 712938000722 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 712938000723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712938000724 homodimer interface [polypeptide binding]; other site 712938000725 catalytic residue [active] 712938000726 UGMP family protein; Validated; Region: PRK09604 712938000727 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 712938000728 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 712938000729 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 712938000730 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 712938000731 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 712938000732 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 712938000733 NAD(P) binding site [chemical binding]; other site 712938000734 active site 712938000735 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 712938000736 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 712938000737 dimer interface [polypeptide binding]; other site 712938000738 active site 712938000739 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 712938000740 ATP-grasp domain; Region: ATP-grasp_4; cl17255 712938000741 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 712938000742 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 712938000743 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 712938000744 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 712938000745 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 712938000746 NAD binding site [chemical binding]; other site 712938000747 homotetramer interface [polypeptide binding]; other site 712938000748 homodimer interface [polypeptide binding]; other site 712938000749 substrate binding site [chemical binding]; other site 712938000750 active site 712938000751 Biotin operon repressor [Transcription]; Region: BirA; COG1654 712938000752 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 712938000753 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 712938000754 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 712938000755 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 712938000756 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 712938000757 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712938000758 Walker A/P-loop; other site 712938000759 ATP binding site [chemical binding]; other site 712938000760 Q-loop/lid; other site 712938000761 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 712938000762 ABC transporter signature motif; other site 712938000763 Walker B; other site 712938000764 D-loop; other site 712938000765 H-loop/switch region; other site 712938000766 ABC transporter; Region: ABC_tran_2; pfam12848 712938000767 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 712938000768 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 712938000769 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 712938000770 ring oligomerisation interface [polypeptide binding]; other site 712938000771 ATP/Mg binding site [chemical binding]; other site 712938000772 stacking interactions; other site 712938000773 hinge regions; other site 712938000774 Amino acid permease; Region: AA_permease_2; pfam13520 712938000775 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 712938000776 ATP-binding site [chemical binding]; other site 712938000777 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 712938000778 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 712938000779 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 712938000780 nucleotide binding region [chemical binding]; other site 712938000781 ATP-binding site [chemical binding]; other site 712938000782 peptide chain release factor 2; Provisional; Region: PRK05589 712938000783 PCRF domain; Region: PCRF; pfam03462 712938000784 RF-1 domain; Region: RF-1; pfam00472 712938000785 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 712938000786 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 712938000787 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 712938000788 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 712938000789 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 712938000790 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 712938000791 active site 712938000792 tetramer interface; other site 712938000793 Predicted amidohydrolase [General function prediction only]; Region: COG0388 712938000794 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 712938000795 putative active site [active] 712938000796 catalytic triad [active] 712938000797 putative dimer interface [polypeptide binding]; other site 712938000798 transaminase; Reviewed; Region: PRK08068 712938000799 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 712938000800 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712938000801 homodimer interface [polypeptide binding]; other site 712938000802 catalytic residue [active] 712938000803 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 712938000804 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 712938000805 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 712938000806 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 712938000807 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 712938000808 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 712938000809 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 712938000810 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 712938000811 conserved cys residue [active] 712938000812 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 712938000813 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 712938000814 dimer interface [polypeptide binding]; other site 712938000815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712938000816 catalytic residue [active] 712938000817 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 712938000818 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 712938000819 homodimer interface [polypeptide binding]; other site 712938000820 substrate-cofactor binding pocket; other site 712938000821 catalytic residue [active] 712938000822 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 712938000823 tetramer (dimer of dimers) interface [polypeptide binding]; other site 712938000824 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 712938000825 NAD binding site [chemical binding]; other site 712938000826 dimer interface [polypeptide binding]; other site 712938000827 substrate binding site [chemical binding]; other site 712938000828 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 712938000829 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 712938000830 active site 712938000831 substrate binding site [chemical binding]; other site 712938000832 metal binding site [ion binding]; metal-binding site 712938000833 excinuclease ABC subunit B; Provisional; Region: PRK05298 712938000834 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 712938000835 ATP binding site [chemical binding]; other site 712938000836 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 712938000837 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 712938000838 active site 712938000839 catalytic site [active] 712938000840 substrate binding site [chemical binding]; other site 712938000841 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 712938000842 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 712938000843 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 712938000844 phosphate binding site [ion binding]; other site 712938000845 putative substrate binding pocket [chemical binding]; other site 712938000846 dimer interface [polypeptide binding]; other site 712938000847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 712938000848 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 712938000849 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 712938000850 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 712938000851 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 712938000852 Phosphoglycerate kinase; Region: PGK; pfam00162 712938000853 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 712938000854 substrate binding site [chemical binding]; other site 712938000855 hinge regions; other site 712938000856 ADP binding site [chemical binding]; other site 712938000857 catalytic site [active] 712938000858 enolase; Provisional; Region: eno; PRK00077 712938000859 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 712938000860 dimer interface [polypeptide binding]; other site 712938000861 metal binding site [ion binding]; metal-binding site 712938000862 substrate binding pocket [chemical binding]; other site 712938000863 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 712938000864 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 712938000865 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 712938000866 Cl- selectivity filter; other site 712938000867 Cl- binding residues [ion binding]; other site 712938000868 pore gating glutamate residue; other site 712938000869 dimer interface [polypeptide binding]; other site 712938000870 H+/Cl- coupling transport residue; other site 712938000871 TrkA-C domain; Region: TrkA_C; pfam02080 712938000872 ribonuclease R; Region: RNase_R; TIGR02063 712938000873 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 712938000874 RNB domain; Region: RNB; pfam00773 712938000875 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 712938000876 RNA binding site [nucleotide binding]; other site 712938000877 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 712938000878 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 712938000879 FAD binding domain; Region: FAD_binding_4; pfam01565 712938000880 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 712938000881 Uncharacterized conserved protein [Function unknown]; Region: COG1624 712938000882 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 712938000883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 712938000884 YbbR-like protein; Region: YbbR; pfam07949 712938000885 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 712938000886 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 712938000887 active site 712938000888 substrate binding site [chemical binding]; other site 712938000889 metal binding site [ion binding]; metal-binding site 712938000890 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 712938000891 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 712938000892 glutaminase active site [active] 712938000893 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 712938000894 dimer interface [polypeptide binding]; other site 712938000895 active site 712938000896 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 712938000897 dimer interface [polypeptide binding]; other site 712938000898 active site 712938000899 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 712938000900 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 712938000901 catalytic triad [active] 712938000902 catalytic triad [active] 712938000903 oxyanion hole [active] 712938000904 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 712938000905 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 712938000906 active site 712938000907 motif I; other site 712938000908 motif II; other site 712938000909 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 712938000910 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 712938000911 Transcriptional regulator [Transcription]; Region: LysR; COG0583 712938000912 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 712938000913 dimerization interface [polypeptide binding]; other site 712938000914 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 712938000915 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 712938000916 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 712938000917 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 712938000918 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 712938000919 active pocket/dimerization site; other site 712938000920 active site 712938000921 phosphorylation site [posttranslational modification] 712938000922 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 712938000923 active site 712938000924 phosphorylation site [posttranslational modification] 712938000925 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 712938000926 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 712938000927 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938000928 MULE transposase domain; Region: MULE; pfam10551 712938000929 putative transposase OrfB; Reviewed; Region: PHA02517 712938000930 HTH-like domain; Region: HTH_21; pfam13276 712938000931 Integrase core domain; Region: rve; pfam00665 712938000932 Integrase core domain; Region: rve_2; pfam13333 712938000933 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 712938000934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 712938000935 active site 712938000936 phosphorylation site [posttranslational modification] 712938000937 intermolecular recognition site; other site 712938000938 dimerization interface [polypeptide binding]; other site 712938000939 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 712938000940 DNA binding site [nucleotide binding] 712938000941 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 712938000942 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 712938000943 dimerization interface [polypeptide binding]; other site 712938000944 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 712938000945 dimer interface [polypeptide binding]; other site 712938000946 phosphorylation site [posttranslational modification] 712938000947 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 712938000948 ATP binding site [chemical binding]; other site 712938000949 Mg2+ binding site [ion binding]; other site 712938000950 G-X-G motif; other site 712938000951 Sugar transport protein; Region: Sugar_transport; pfam06800 712938000952 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 712938000953 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 712938000954 nucleotide binding site [chemical binding]; other site 712938000955 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 712938000956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938000957 putative substrate translocation pore; other site 712938000958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938000959 xylose isomerase; Provisional; Region: PRK05474 712938000960 xylose isomerase; Region: xylose_isom_A; TIGR02630 712938000961 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 712938000962 N- and C-terminal domain interface [polypeptide binding]; other site 712938000963 D-xylulose kinase; Region: XylB; TIGR01312 712938000964 active site 712938000965 MgATP binding site [chemical binding]; other site 712938000966 catalytic site [active] 712938000967 metal binding site [ion binding]; metal-binding site 712938000968 xylulose binding site [chemical binding]; other site 712938000969 homodimer interface [polypeptide binding]; other site 712938000970 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 712938000971 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 712938000972 inhibitor binding site; inhibition site 712938000973 active site 712938000974 Major Facilitator Superfamily; Region: MFS_1; pfam07690 712938000975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938000976 putative substrate translocation pore; other site 712938000977 putative transposase OrfB; Reviewed; Region: PHA02517 712938000978 HTH-like domain; Region: HTH_21; pfam13276 712938000979 Integrase core domain; Region: rve; pfam00665 712938000980 Integrase core domain; Region: rve_2; pfam13333 712938000981 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 712938000982 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 712938000983 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 712938000984 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 712938000985 catalytic residue [active] 712938000986 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 712938000987 catalytic residues [active] 712938000988 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 712938000989 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 712938000990 active site 712938000991 dimer interface [polypeptide binding]; other site 712938000992 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 712938000993 dimer interface [polypeptide binding]; other site 712938000994 active site 712938000995 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 712938000996 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 712938000997 active site 712938000998 catalytic tetrad [active] 712938000999 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 712938001000 triosephosphate isomerase; Provisional; Region: PRK14565 712938001001 substrate binding site [chemical binding]; other site 712938001002 dimer interface [polypeptide binding]; other site 712938001003 catalytic triad [active] 712938001004 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 712938001005 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 712938001006 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 712938001007 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712938001008 Walker A/P-loop; other site 712938001009 ATP binding site [chemical binding]; other site 712938001010 Q-loop/lid; other site 712938001011 ABC transporter signature motif; other site 712938001012 Walker B; other site 712938001013 D-loop; other site 712938001014 H-loop/switch region; other site 712938001015 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 712938001016 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 712938001017 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 712938001018 Walker A/P-loop; other site 712938001019 ATP binding site [chemical binding]; other site 712938001020 Q-loop/lid; other site 712938001021 ABC transporter signature motif; other site 712938001022 Walker B; other site 712938001023 D-loop; other site 712938001024 H-loop/switch region; other site 712938001025 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 712938001026 Beta-lactamase; Region: Beta-lactamase; pfam00144 712938001027 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 712938001028 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 712938001029 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 712938001030 putative active site [active] 712938001031 catalytic site [active] 712938001032 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 712938001033 putative active site [active] 712938001034 catalytic site [active] 712938001035 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 712938001036 catalytic triad [active] 712938001037 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 712938001038 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 712938001039 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 712938001040 peptide chain release factor 1; Validated; Region: prfA; PRK00591 712938001041 This domain is found in peptide chain release factors; Region: PCRF; smart00937 712938001042 RF-1 domain; Region: RF-1; pfam00472 712938001043 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 712938001044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 712938001045 S-adenosylmethionine binding site [chemical binding]; other site 712938001046 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 712938001047 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 712938001048 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 712938001049 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 712938001050 dimer interface [polypeptide binding]; other site 712938001051 active site 712938001052 glycine-pyridoxal phosphate binding site [chemical binding]; other site 712938001053 folate binding site [chemical binding]; other site 712938001054 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 712938001055 active site 712938001056 YibE/F-like protein; Region: YibE_F; pfam07907 712938001057 YibE/F-like protein; Region: YibE_F; cl02259 712938001058 uracil transporter; Provisional; Region: PRK10720 712938001059 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 712938001060 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 712938001061 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 712938001062 beta subunit interaction interface [polypeptide binding]; other site 712938001063 Walker A motif; other site 712938001064 ATP binding site [chemical binding]; other site 712938001065 Walker B motif; other site 712938001066 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 712938001067 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 712938001068 core domain interface [polypeptide binding]; other site 712938001069 delta subunit interface [polypeptide binding]; other site 712938001070 epsilon subunit interface [polypeptide binding]; other site 712938001071 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 712938001072 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 712938001073 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 712938001074 alpha subunit interaction interface [polypeptide binding]; other site 712938001075 Walker A motif; other site 712938001076 ATP binding site [chemical binding]; other site 712938001077 Walker B motif; other site 712938001078 inhibitor binding site; inhibition site 712938001079 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 712938001080 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 712938001081 rod shape-determining protein MreB; Provisional; Region: PRK13930 712938001082 MreB and similar proteins; Region: MreB_like; cd10225 712938001083 nucleotide binding site [chemical binding]; other site 712938001084 Mg binding site [ion binding]; other site 712938001085 putative protofilament interaction site [polypeptide binding]; other site 712938001086 RodZ interaction site [polypeptide binding]; other site 712938001087 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 712938001088 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 712938001089 lipoyl-biotinyl attachment site [posttranslational modification]; other site 712938001090 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 712938001091 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 712938001092 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 712938001093 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 712938001094 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 712938001095 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 712938001096 non-specific DNA binding site [nucleotide binding]; other site 712938001097 salt bridge; other site 712938001098 sequence-specific DNA binding site [nucleotide binding]; other site 712938001099 Tetratricopeptide repeat; Region: TPR_12; pfam13424 712938001100 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 712938001101 binding surface 712938001102 TPR motif; other site 712938001103 recombination factor protein RarA; Reviewed; Region: PRK13342 712938001104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712938001105 Walker A motif; other site 712938001106 ATP binding site [chemical binding]; other site 712938001107 Walker B motif; other site 712938001108 arginine finger; other site 712938001109 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 712938001110 Uncharacterized conserved protein [Function unknown]; Region: COG1284 712938001111 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 712938001112 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 712938001113 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 712938001114 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 712938001115 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 712938001116 Int/Topo IB signature motif; other site 712938001117 DEAD-like helicases superfamily; Region: DEXDc; smart00487 712938001118 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 712938001119 ATP binding site [chemical binding]; other site 712938001120 putative Mg++ binding site [ion binding]; other site 712938001121 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 712938001122 nucleotide binding region [chemical binding]; other site 712938001123 ATP-binding site [chemical binding]; other site 712938001124 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 712938001125 Uncharacterized conserved protein [Function unknown]; Region: COG4983 712938001126 D5 N terminal like; Region: D5_N; pfam08706 712938001127 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 712938001128 Phage Terminase; Region: Terminase_1; pfam03354 712938001129 Phage-related protein [Function unknown]; Region: COG4695; cl01923 712938001130 Phage portal protein; Region: Phage_portal; pfam04860 712938001131 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 712938001132 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 712938001133 Phage capsid family; Region: Phage_capsid; pfam05065 712938001134 Phage-related tail protein [Function unknown]; Region: COG5283 712938001135 tape measure domain; Region: tape_meas_nterm; TIGR02675 712938001136 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 712938001137 N-acetyl-D-glucosamine binding site [chemical binding]; other site 712938001138 catalytic residue [active] 712938001139 Phage tail protein; Region: Sipho_tail; pfam05709 712938001140 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 712938001141 active site 712938001142 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 712938001143 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 712938001144 NlpC/P60 family; Region: NLPC_P60; cl17555 712938001145 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 712938001146 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 712938001147 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 712938001148 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 712938001149 active site 712938001150 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 712938001151 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 712938001152 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 712938001153 septation ring formation regulator EzrA; Provisional; Region: PRK04778 712938001154 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 712938001155 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 712938001156 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 712938001157 catalytic residue [active] 712938001158 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 712938001159 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 712938001160 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 712938001161 Ligand Binding Site [chemical binding]; other site 712938001162 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 712938001163 fructuronate transporter; Provisional; Region: PRK10034; cl15264 712938001164 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 712938001165 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 712938001166 Probable transposase; Region: OrfB_IS605; pfam01385 712938001167 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 712938001168 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 712938001169 active site 712938001170 HIGH motif; other site 712938001171 nucleotide binding site [chemical binding]; other site 712938001172 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 712938001173 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 712938001174 active site 712938001175 KMSKS motif; other site 712938001176 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 712938001177 tRNA binding surface [nucleotide binding]; other site 712938001178 anticodon binding site; other site 712938001179 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 712938001180 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 712938001181 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 712938001182 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 712938001183 rod shape-determining protein MreB; Provisional; Region: PRK13927 712938001184 MreB and similar proteins; Region: MreB_like; cd10225 712938001185 nucleotide binding site [chemical binding]; other site 712938001186 Mg binding site [ion binding]; other site 712938001187 putative protofilament interaction site [polypeptide binding]; other site 712938001188 RodZ interaction site [polypeptide binding]; other site 712938001189 rod shape-determining protein MreC; Provisional; Region: PRK13922 712938001190 rod shape-determining protein MreC; Region: MreC; pfam04085 712938001191 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 712938001192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 712938001193 dimer interface [polypeptide binding]; other site 712938001194 conserved gate region; other site 712938001195 putative PBP binding loops; other site 712938001196 ABC-ATPase subunit interface; other site 712938001197 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 712938001198 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 712938001199 substrate binding pocket [chemical binding]; other site 712938001200 membrane-bound complex binding site; other site 712938001201 hinge residues; other site 712938001202 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 712938001203 MutS domain I; Region: MutS_I; pfam01624 712938001204 MutS domain II; Region: MutS_II; pfam05188 712938001205 MutS domain III; Region: MutS_III; pfam05192 712938001206 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 712938001207 Walker A/P-loop; other site 712938001208 ATP binding site [chemical binding]; other site 712938001209 Q-loop/lid; other site 712938001210 ABC transporter signature motif; other site 712938001211 Walker B; other site 712938001212 D-loop; other site 712938001213 H-loop/switch region; other site 712938001214 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 712938001215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 712938001216 ATP binding site [chemical binding]; other site 712938001217 Mg2+ binding site [ion binding]; other site 712938001218 G-X-G motif; other site 712938001219 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 712938001220 ATP binding site [chemical binding]; other site 712938001221 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 712938001222 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 712938001223 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 712938001224 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 712938001225 DHH family; Region: DHH; pfam01368 712938001226 DHHA1 domain; Region: DHHA1; pfam02272 712938001227 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 712938001228 DEAD-like helicases superfamily; Region: DEXDc; smart00487 712938001229 ATP binding site [chemical binding]; other site 712938001230 Mg++ binding site [ion binding]; other site 712938001231 motif III; other site 712938001232 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 712938001233 nucleotide binding region [chemical binding]; other site 712938001234 ATP-binding site [chemical binding]; other site 712938001235 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 712938001236 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 712938001237 motif 1; other site 712938001238 active site 712938001239 motif 2; other site 712938001240 motif 3; other site 712938001241 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 712938001242 DHHA1 domain; Region: DHHA1; pfam02272 712938001243 ribonuclease HIII; Provisional; Region: PRK00996 712938001244 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 712938001245 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 712938001246 RNA/DNA hybrid binding site [nucleotide binding]; other site 712938001247 active site 712938001248 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 712938001249 MutS domain III; Region: MutS_III; pfam05192 712938001250 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712938001251 Walker A/P-loop; other site 712938001252 ATP binding site [chemical binding]; other site 712938001253 Q-loop/lid; other site 712938001254 ABC transporter signature motif; other site 712938001255 Walker B; other site 712938001256 D-loop; other site 712938001257 H-loop/switch region; other site 712938001258 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 712938001259 Smr domain; Region: Smr; pfam01713 712938001260 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 712938001261 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 712938001262 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 712938001263 putative ion selectivity filter; other site 712938001264 putative pore gating glutamate residue; other site 712938001265 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 712938001266 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 712938001267 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 712938001268 active site 712938001269 motif I; other site 712938001270 motif II; other site 712938001271 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 712938001272 Mechanosensitive ion channel; Region: MS_channel; pfam00924 712938001273 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 712938001274 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 712938001275 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 712938001276 active site 712938001277 catabolite control protein A; Region: ccpA; TIGR01481 712938001278 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 712938001279 DNA binding site [nucleotide binding] 712938001280 domain linker motif; other site 712938001281 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 712938001282 dimerization interface [polypeptide binding]; other site 712938001283 effector binding site; other site 712938001284 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 712938001285 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 712938001286 NlpC/P60 family; Region: NLPC_P60; pfam00877 712938001287 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 712938001288 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 712938001289 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 712938001290 Type II/IV secretion system protein; Region: T2SE; pfam00437 712938001291 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 712938001292 Walker A motif; other site 712938001293 ATP binding site [chemical binding]; other site 712938001294 Walker B motif; other site 712938001295 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 712938001296 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 712938001297 Methyltransferase domain; Region: Methyltransf_26; pfam13659 712938001298 S-adenosylmethionine binding site [chemical binding]; other site 712938001299 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 712938001300 propionate/acetate kinase; Provisional; Region: PRK12379 712938001301 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 712938001302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 712938001303 active site 712938001304 motif I; other site 712938001305 motif II; other site 712938001306 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 712938001307 Competence protein CoiA-like family; Region: CoiA; cl11541 712938001308 Thioredoxin; Region: Thioredoxin_5; pfam13743 712938001309 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 712938001310 ATP-NAD kinase; Region: NAD_kinase; pfam01513 712938001311 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 712938001312 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 712938001313 active site 712938001314 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 712938001315 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 712938001316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 712938001317 S-adenosylmethionine binding site [chemical binding]; other site 712938001318 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 712938001319 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 712938001320 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 712938001321 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 712938001322 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 712938001323 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 712938001324 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 712938001325 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 712938001326 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 712938001327 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 712938001328 Mg++ binding site [ion binding]; other site 712938001329 putative catalytic motif [active] 712938001330 putative substrate binding site [chemical binding]; other site 712938001331 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 712938001332 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 712938001333 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 712938001334 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 712938001335 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 712938001336 Cell division protein FtsQ; Region: FtsQ; pfam03799 712938001337 cell division protein FtsA; Region: ftsA; TIGR01174 712938001338 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 712938001339 nucleotide binding site [chemical binding]; other site 712938001340 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 712938001341 Cell division protein FtsA; Region: FtsA; pfam14450 712938001342 cell division protein FtsZ; Validated; Region: PRK09330 712938001343 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 712938001344 nucleotide binding site [chemical binding]; other site 712938001345 SulA interaction site; other site 712938001346 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 712938001347 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 712938001348 RNA binding surface [nucleotide binding]; other site 712938001349 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 712938001350 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 712938001351 active site 712938001352 HIGH motif; other site 712938001353 nucleotide binding site [chemical binding]; other site 712938001354 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 712938001355 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 712938001356 active site 712938001357 KMSKS motif; other site 712938001358 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 712938001359 tRNA binding surface [nucleotide binding]; other site 712938001360 anticodon binding site; other site 712938001361 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 712938001362 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 712938001363 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 712938001364 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 712938001365 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 712938001366 active site 712938001367 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 712938001368 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 712938001369 tetramer (dimer of dimers) interface [polypeptide binding]; other site 712938001370 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 712938001371 NAD binding site [chemical binding]; other site 712938001372 dimer interface [polypeptide binding]; other site 712938001373 substrate binding site [chemical binding]; other site 712938001374 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 712938001375 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 712938001376 AAA domain; Region: AAA_30; pfam13604 712938001377 Family description; Region: UvrD_C_2; pfam13538 712938001378 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 712938001379 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 712938001380 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 712938001381 G1 box; other site 712938001382 putative GEF interaction site [polypeptide binding]; other site 712938001383 GTP/Mg2+ binding site [chemical binding]; other site 712938001384 Switch I region; other site 712938001385 G2 box; other site 712938001386 G3 box; other site 712938001387 Switch II region; other site 712938001388 G4 box; other site 712938001389 G5 box; other site 712938001390 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 712938001391 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 712938001392 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 712938001393 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 712938001394 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 712938001395 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 712938001396 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 712938001397 Competence protein; Region: Competence; pfam03772 712938001398 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 712938001399 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 712938001400 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 712938001401 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 712938001402 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 712938001403 Integrase core domain; Region: rve; pfam00665 712938001404 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 712938001405 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 712938001406 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 712938001407 elongation factor Tu; Reviewed; Region: PRK00049 712938001408 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 712938001409 G1 box; other site 712938001410 GEF interaction site [polypeptide binding]; other site 712938001411 GTP/Mg2+ binding site [chemical binding]; other site 712938001412 Switch I region; other site 712938001413 G2 box; other site 712938001414 G3 box; other site 712938001415 Switch II region; other site 712938001416 G4 box; other site 712938001417 G5 box; other site 712938001418 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 712938001419 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 712938001420 Antibiotic Binding Site [chemical binding]; other site 712938001421 trigger factor; Provisional; Region: tig; PRK01490 712938001422 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 712938001423 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 712938001424 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 712938001425 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 712938001426 Walker B motif; other site 712938001427 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 712938001428 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 712938001429 G4 box; other site 712938001430 G5 box; other site 712938001431 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 712938001432 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 712938001433 Walker A/P-loop; other site 712938001434 ATP binding site [chemical binding]; other site 712938001435 Q-loop/lid; other site 712938001436 ABC transporter signature motif; other site 712938001437 Walker B; other site 712938001438 D-loop; other site 712938001439 H-loop/switch region; other site 712938001440 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 712938001441 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 712938001442 GIY-YIG motif/motif A; other site 712938001443 active site 712938001444 catalytic site [active] 712938001445 putative DNA binding site [nucleotide binding]; other site 712938001446 metal binding site [ion binding]; metal-binding site 712938001447 UvrB/uvrC motif; Region: UVR; pfam02151 712938001448 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 712938001449 Obg GTPase; Region: Obg; cd01898 712938001450 G3 box; other site 712938001451 Switch II region; other site 712938001452 G4 box; other site 712938001453 G5 box; other site 712938001454 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 712938001455 ribonuclease Z; Region: RNase_Z; TIGR02651 712938001456 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 712938001457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 712938001458 NAD(P) binding site [chemical binding]; other site 712938001459 active site 712938001460 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 712938001461 DHH family; Region: DHH; pfam01368 712938001462 DHHA1 domain; Region: DHHA1; pfam02272 712938001463 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 712938001464 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 712938001465 homodimer interface [polypeptide binding]; other site 712938001466 ligand binding site [chemical binding]; other site 712938001467 NAD binding site [chemical binding]; other site 712938001468 catalytic site [active] 712938001469 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 712938001470 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 712938001471 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 712938001472 dimer interface [polypeptide binding]; other site 712938001473 active site 712938001474 metal binding site [ion binding]; metal-binding site 712938001475 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 712938001476 asparagine synthetase B; Provisional; Region: asnB; PRK09431 712938001477 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 712938001478 active site 712938001479 dimer interface [polypeptide binding]; other site 712938001480 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 712938001481 Ligand Binding Site [chemical binding]; other site 712938001482 Molecular Tunnel; other site 712938001483 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 712938001484 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 712938001485 Probable transposase; Region: OrfB_IS605; pfam01385 712938001486 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 712938001487 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 712938001488 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 712938001489 Int/Topo IB signature motif; other site 712938001490 Ion channel; Region: Ion_trans_2; pfam07885 712938001491 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 712938001492 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 712938001493 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938001494 MULE transposase domain; Region: MULE; pfam10551 712938001495 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 712938001496 potential frameshift: common BLAST hit: gi|170016309|ref|YP_001727229.1| mucus binding protein 712938001497 MucBP domain; Region: MucBP; pfam06458 712938001498 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 712938001499 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712938001500 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712938001501 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 712938001502 Integrase core domain; Region: rve; pfam00665 712938001503 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938001504 MULE transposase domain; Region: MULE; pfam10551 712938001505 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938001506 MULE transposase domain; Region: MULE; pfam10551 712938001507 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938001508 MULE transposase domain; Region: MULE; pfam10551 712938001509 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 712938001510 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712938001511 Walker A/P-loop; other site 712938001512 ATP binding site [chemical binding]; other site 712938001513 Q-loop/lid; other site 712938001514 ABC transporter signature motif; other site 712938001515 Walker B; other site 712938001516 D-loop; other site 712938001517 H-loop/switch region; other site 712938001518 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 712938001519 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712938001520 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712938001521 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 712938001522 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938001523 MULE transposase domain; Region: MULE; pfam10551 712938001524 helicase Cas3; Provisional; Region: PRK09694 712938001525 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 712938001526 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 712938001527 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938001528 MULE transposase domain; Region: MULE; pfam10551 712938001529 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 712938001530 CT1975-like protein; Region: Cas_CT1975; pfam09344 712938001531 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 712938001532 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 712938001533 Integrase core domain; Region: rve; pfam00665 712938001534 HTH-like domain; Region: HTH_21; pfam13276 712938001535 Integrase core domain; Region: rve; pfam00665 712938001536 Domain of unknown function (DUF389); Region: DUF389; pfam04087 712938001537 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 712938001538 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 712938001539 dimer interface [polypeptide binding]; other site 712938001540 LexA repressor; Validated; Region: PRK00215 712938001541 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 712938001542 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 712938001543 Catalytic site [active] 712938001544 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 712938001545 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 712938001546 rRNA interaction site [nucleotide binding]; other site 712938001547 S8 interaction site; other site 712938001548 putative laminin-1 binding site; other site 712938001549 elongation factor Ts; Provisional; Region: tsf; PRK09377 712938001550 UBA/TS-N domain; Region: UBA; pfam00627 712938001551 Elongation factor TS; Region: EF_TS; pfam00889 712938001552 Elongation factor TS; Region: EF_TS; pfam00889 712938001553 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 712938001554 putative nucleotide binding site [chemical binding]; other site 712938001555 uridine monophosphate binding site [chemical binding]; other site 712938001556 homohexameric interface [polypeptide binding]; other site 712938001557 Ribosome recycling factor; Region: RRF; pfam01765 712938001558 hinge region; other site 712938001559 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 712938001560 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 712938001561 catalytic residue [active] 712938001562 putative FPP diphosphate binding site; other site 712938001563 putative FPP binding hydrophobic cleft; other site 712938001564 dimer interface [polypeptide binding]; other site 712938001565 putative IPP diphosphate binding site; other site 712938001566 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 712938001567 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 712938001568 RIP metalloprotease RseP; Region: TIGR00054 712938001569 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 712938001570 active site 712938001571 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 712938001572 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 712938001573 protein binding site [polypeptide binding]; other site 712938001574 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 712938001575 putative substrate binding region [chemical binding]; other site 712938001576 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 712938001577 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 712938001578 inhibitor-cofactor binding pocket; inhibition site 712938001579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712938001580 catalytic residue [active] 712938001581 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 712938001582 heterotetramer interface [polypeptide binding]; other site 712938001583 active site pocket [active] 712938001584 cleavage site 712938001585 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 712938001586 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 712938001587 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 712938001588 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 712938001589 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 712938001590 catalytic site [active] 712938001591 subunit interface [polypeptide binding]; other site 712938001592 carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369 712938001593 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 712938001594 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 712938001595 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 712938001596 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 712938001597 ATP-grasp domain; Region: ATP-grasp_4; cl17255 712938001598 ribosome maturation protein RimP; Reviewed; Region: PRK00092 712938001599 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 712938001600 putative oligomer interface [polypeptide binding]; other site 712938001601 putative RNA binding site [nucleotide binding]; other site 712938001602 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 712938001603 NusA N-terminal domain; Region: NusA_N; pfam08529 712938001604 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 712938001605 RNA binding site [nucleotide binding]; other site 712938001606 homodimer interface [polypeptide binding]; other site 712938001607 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 712938001608 G-X-X-G motif; other site 712938001609 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 712938001610 G-X-X-G motif; other site 712938001611 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 712938001612 translation initiation factor IF-2; Region: IF-2; TIGR00487 712938001613 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 712938001614 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 712938001615 G1 box; other site 712938001616 putative GEF interaction site [polypeptide binding]; other site 712938001617 GTP/Mg2+ binding site [chemical binding]; other site 712938001618 Switch I region; other site 712938001619 G2 box; other site 712938001620 G3 box; other site 712938001621 Switch II region; other site 712938001622 G4 box; other site 712938001623 G5 box; other site 712938001624 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 712938001625 Translation-initiation factor 2; Region: IF-2; pfam11987 712938001626 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 712938001627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938001628 Major Facilitator Superfamily; Region: MFS_1; pfam07690 712938001629 putative substrate translocation pore; other site 712938001630 Major Facilitator Superfamily; Region: MFS_1; pfam07690 712938001631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938001632 putative substrate translocation pore; other site 712938001633 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 712938001634 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 712938001635 Ca binding site [ion binding]; other site 712938001636 active site 712938001637 catalytic site [active] 712938001638 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 712938001639 Transcriptional regulators [Transcription]; Region: PurR; COG1609 712938001640 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 712938001641 DNA binding site [nucleotide binding] 712938001642 domain linker motif; other site 712938001643 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 712938001644 dimerization interface [polypeptide binding]; other site 712938001645 ligand binding site [chemical binding]; other site 712938001646 DNA polymerase IV; Reviewed; Region: PRK03103 712938001647 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 712938001648 active site 712938001649 DNA binding site [nucleotide binding] 712938001650 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 712938001651 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 712938001652 dimer interface [polypeptide binding]; other site 712938001653 active site 712938001654 metal binding site [ion binding]; metal-binding site 712938001655 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 712938001656 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 712938001657 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 712938001658 D-serine dehydratase; Provisional; Region: PRK02991 712938001659 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 712938001660 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 712938001661 catalytic residue [active] 712938001662 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 712938001663 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 712938001664 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 712938001665 GrpE; Region: GrpE; pfam01025 712938001666 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 712938001667 dimer interface [polypeptide binding]; other site 712938001668 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 712938001669 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 712938001670 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 712938001671 nucleotide binding site [chemical binding]; other site 712938001672 NEF interaction site [polypeptide binding]; other site 712938001673 SBD interface [polypeptide binding]; other site 712938001674 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 712938001675 HSP70 interaction site [polypeptide binding]; other site 712938001676 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 712938001677 substrate binding site [polypeptide binding]; other site 712938001678 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 712938001679 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 712938001680 Zn binding sites [ion binding]; other site 712938001681 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 712938001682 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 712938001683 conserved cys residue [active] 712938001684 histidinol-phosphatase; Reviewed; Region: PRK08123 712938001685 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 712938001686 active site 712938001687 dimer interface [polypeptide binding]; other site 712938001688 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 712938001689 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 712938001690 histidinol dehydrogenase; Region: hisD; TIGR00069 712938001691 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 712938001692 NAD binding site [chemical binding]; other site 712938001693 dimerization interface [polypeptide binding]; other site 712938001694 product binding site; other site 712938001695 substrate binding site [chemical binding]; other site 712938001696 zinc binding site [ion binding]; other site 712938001697 catalytic residues [active] 712938001698 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 712938001699 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 712938001700 substrate binding site [chemical binding]; other site 712938001701 glutamase interaction surface [polypeptide binding]; other site 712938001702 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 712938001703 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 712938001704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712938001705 homodimer interface [polypeptide binding]; other site 712938001706 catalytic residue [active] 712938001707 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 712938001708 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 712938001709 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 712938001710 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 712938001711 catalytic residue [active] 712938001712 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 712938001713 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 712938001714 L-serine binding site [chemical binding]; other site 712938001715 ACT domain interface; other site 712938001716 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 712938001717 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 712938001718 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 712938001719 dimerization interface [polypeptide binding]; other site 712938001720 active site 712938001721 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 712938001722 Integrase core domain; Region: rve; pfam00665 712938001723 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 712938001724 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 712938001725 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 712938001726 catalytic residue [active] 712938001727 Probable transposase; Region: OrfB_IS605; pfam01385 712938001728 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 712938001729 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 712938001730 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 712938001731 metal binding site [ion binding]; metal-binding site 712938001732 dimer interface [polypeptide binding]; other site 712938001733 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 712938001734 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 712938001735 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 712938001736 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 712938001737 catalytic Zn binding site [ion binding]; other site 712938001738 NAD binding site [chemical binding]; other site 712938001739 structural Zn binding site [ion binding]; other site 712938001740 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 712938001741 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 712938001742 active site 712938001743 dimer interface [polypeptide binding]; other site 712938001744 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 712938001745 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 712938001746 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 712938001747 active site 712938001748 FMN binding site [chemical binding]; other site 712938001749 substrate binding site [chemical binding]; other site 712938001750 3Fe-4S cluster binding site [ion binding]; other site 712938001751 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 712938001752 domain interface; other site 712938001753 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 712938001754 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 712938001755 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 712938001756 NAD binding site [chemical binding]; other site 712938001757 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 712938001758 dimer interface [polypeptide binding]; other site 712938001759 substrate binding site [chemical binding]; other site 712938001760 ATP binding site [chemical binding]; other site 712938001761 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 712938001762 substrate binding site [chemical binding]; other site 712938001763 multimerization interface [polypeptide binding]; other site 712938001764 ATP binding site [chemical binding]; other site 712938001765 conserved hypothetical integral membrane protein; Region: TIGR03766 712938001766 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 712938001767 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 712938001768 tetramer (dimer of dimers) interface [polypeptide binding]; other site 712938001769 NAD binding site [chemical binding]; other site 712938001770 dimer interface [polypeptide binding]; other site 712938001771 substrate binding site [chemical binding]; other site 712938001772 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 712938001773 RNA methyltransferase, RsmE family; Region: TIGR00046 712938001774 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 712938001775 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 712938001776 Zn2+ binding site [ion binding]; other site 712938001777 Mg2+ binding site [ion binding]; other site 712938001778 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 712938001779 synthetase active site [active] 712938001780 NTP binding site [chemical binding]; other site 712938001781 metal binding site [ion binding]; metal-binding site 712938001782 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 712938001783 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 712938001784 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 712938001785 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 712938001786 catalytic residue [active] 712938001787 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 712938001788 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 712938001789 homodimer interface [polypeptide binding]; other site 712938001790 substrate-cofactor binding pocket; other site 712938001791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712938001792 catalytic residue [active] 712938001793 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 712938001794 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 712938001795 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 712938001796 substrate binding pocket [chemical binding]; other site 712938001797 membrane-bound complex binding site; other site 712938001798 hinge residues; other site 712938001799 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 712938001800 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 712938001801 substrate binding pocket [chemical binding]; other site 712938001802 membrane-bound complex binding site; other site 712938001803 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 712938001804 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 712938001805 NAD(P) binding site [chemical binding]; other site 712938001806 active site 712938001807 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 712938001808 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 712938001809 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 712938001810 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 712938001811 conserved cys residue [active] 712938001812 S-methylmethionine transporter; Provisional; Region: PRK11387 712938001813 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 712938001814 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 712938001815 Phosphotransferase enzyme family; Region: APH; pfam01636 712938001816 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 712938001817 active site 712938001818 substrate binding site [chemical binding]; other site 712938001819 ATP binding site [chemical binding]; other site 712938001820 Ecdysteroid kinase; Region: EcKinase; cl17738 712938001821 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 712938001822 substrate binding site [chemical binding]; other site 712938001823 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 712938001824 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 712938001825 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 712938001826 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 712938001827 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 712938001828 dimer interface [polypeptide binding]; other site 712938001829 motif 1; other site 712938001830 active site 712938001831 motif 2; other site 712938001832 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 712938001833 anticodon binding site; other site 712938001834 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 712938001835 GAD domain; Region: GAD; pfam02938 712938001836 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 712938001837 active site 712938001838 motif 3; other site 712938001839 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 712938001840 catalytic triad [active] 712938001841 Yqey-like protein; Region: YqeY; pfam09424 712938001842 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 712938001843 PhoH-like protein; Region: PhoH; pfam02562 712938001844 GTPase Era; Reviewed; Region: era; PRK00089 712938001845 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 712938001846 G1 box; other site 712938001847 GTP/Mg2+ binding site [chemical binding]; other site 712938001848 Switch I region; other site 712938001849 G2 box; other site 712938001850 Switch II region; other site 712938001851 G3 box; other site 712938001852 G4 box; other site 712938001853 G5 box; other site 712938001854 Recombination protein O N terminal; Region: RecO_N; pfam11967 712938001855 DNA repair protein RecO; Region: reco; TIGR00613 712938001856 Recombination protein O C terminal; Region: RecO_C; pfam02565 712938001857 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 712938001858 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 712938001859 interdomain interaction site; other site 712938001860 active site 712938001861 metal binding site [ion binding]; metal-binding site 712938001862 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 712938001863 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 712938001864 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 712938001865 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 712938001866 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 712938001867 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712938001868 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712938001869 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 712938001870 ApbE family; Region: ApbE; pfam02424 712938001871 aspartate kinase; Reviewed; Region: PRK09034 712938001872 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 712938001873 putative catalytic residues [active] 712938001874 putative nucleotide binding site [chemical binding]; other site 712938001875 putative aspartate binding site [chemical binding]; other site 712938001876 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 712938001877 allosteric regulatory residue; other site 712938001878 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 712938001879 diaminopimelate decarboxylase; Region: lysA; TIGR01048 712938001880 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 712938001881 active site 712938001882 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 712938001883 substrate binding site [chemical binding]; other site 712938001884 catalytic residues [active] 712938001885 dimer interface [polypeptide binding]; other site 712938001886 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 712938001887 putative trimer interface [polypeptide binding]; other site 712938001888 putative CoA binding site [chemical binding]; other site 712938001889 Class I aldolases; Region: Aldolase_Class_I; cl17187 712938001890 aromatic amino acid aminotransferase; Validated; Region: PRK07309 712938001891 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 712938001892 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712938001893 homodimer interface [polypeptide binding]; other site 712938001894 catalytic residue [active] 712938001895 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 712938001896 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 712938001897 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 712938001898 Uncharacterized conserved protein [Function unknown]; Region: COG0327 712938001899 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 712938001900 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 712938001901 metal binding site [ion binding]; metal-binding site 712938001902 dimer interface [polypeptide binding]; other site 712938001903 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 712938001904 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 712938001905 domain interfaces; other site 712938001906 active site 712938001907 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 712938001908 S1 domain; Region: S1_2; pfam13509 712938001909 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 712938001910 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 712938001911 active site 712938001912 DNA binding site [nucleotide binding] 712938001913 Int/Topo IB signature motif; other site 712938001914 ScpA/B protein; Region: ScpA_ScpB; cl00598 712938001915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 712938001916 DEAD-like helicases superfamily; Region: DEXDc; smart00487 712938001917 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 712938001918 ATP binding site [chemical binding]; other site 712938001919 putative Mg++ binding site [ion binding]; other site 712938001920 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 712938001921 nucleotide binding region [chemical binding]; other site 712938001922 ATP-binding site [chemical binding]; other site 712938001923 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 712938001924 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 712938001925 RNA binding site [nucleotide binding]; other site 712938001926 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 712938001927 RNA binding site [nucleotide binding]; other site 712938001928 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 712938001929 RNA binding site [nucleotide binding]; other site 712938001930 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 712938001931 RNA binding site [nucleotide binding]; other site 712938001932 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 712938001933 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 712938001934 G1 box; other site 712938001935 GTP/Mg2+ binding site [chemical binding]; other site 712938001936 Switch I region; other site 712938001937 G2 box; other site 712938001938 Switch II region; other site 712938001939 G3 box; other site 712938001940 G4 box; other site 712938001941 G5 box; other site 712938001942 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 712938001943 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 712938001944 G1 box; other site 712938001945 GTP/Mg2+ binding site [chemical binding]; other site 712938001946 Switch I region; other site 712938001947 G2 box; other site 712938001948 G3 box; other site 712938001949 Switch II region; other site 712938001950 G4 box; other site 712938001951 G5 box; other site 712938001952 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 712938001953 TPR motif; other site 712938001954 binding surface 712938001955 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 712938001956 binding surface 712938001957 TPR motif; other site 712938001958 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 712938001959 TPR motif; other site 712938001960 binding surface 712938001961 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 712938001962 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 712938001963 active site 712938001964 NTP binding site [chemical binding]; other site 712938001965 metal binding triad [ion binding]; metal-binding site 712938001966 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 712938001967 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 712938001968 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 712938001969 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712938001970 Walker A/P-loop; other site 712938001971 ATP binding site [chemical binding]; other site 712938001972 Q-loop/lid; other site 712938001973 ABC transporter signature motif; other site 712938001974 Walker B; other site 712938001975 D-loop; other site 712938001976 H-loop/switch region; other site 712938001977 ABC transporter; Region: ABC_tran_2; pfam12848 712938001978 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 712938001979 thymidylate synthase; Region: thym_sym; TIGR03284 712938001980 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 712938001981 dimerization interface [polypeptide binding]; other site 712938001982 active site 712938001983 EDD domain protein, DegV family; Region: DegV; TIGR00762 712938001984 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 712938001985 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 712938001986 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 712938001987 putative ligand binding site [chemical binding]; other site 712938001988 putative NAD binding site [chemical binding]; other site 712938001989 putative catalytic site [active] 712938001990 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 712938001991 CoA binding site [chemical binding]; other site 712938001992 active site 712938001993 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 712938001994 active site 712938001995 catalytic triad [active] 712938001996 oxyanion hole [active] 712938001997 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 712938001998 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 712938001999 GTP/Mg2+ binding site [chemical binding]; other site 712938002000 G4 box; other site 712938002001 G5 box; other site 712938002002 G1 box; other site 712938002003 Switch I region; other site 712938002004 G2 box; other site 712938002005 G3 box; other site 712938002006 Switch II region; other site 712938002007 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 712938002008 RNA/DNA hybrid binding site [nucleotide binding]; other site 712938002009 active site 712938002010 DNA protecting protein DprA; Region: dprA; TIGR00732 712938002011 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 712938002012 DNA topoisomerase I; Validated; Region: PRK05582 712938002013 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 712938002014 active site 712938002015 interdomain interaction site; other site 712938002016 putative metal-binding site [ion binding]; other site 712938002017 nucleotide binding site [chemical binding]; other site 712938002018 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 712938002019 domain I; other site 712938002020 DNA binding groove [nucleotide binding] 712938002021 phosphate binding site [ion binding]; other site 712938002022 domain II; other site 712938002023 domain III; other site 712938002024 nucleotide binding site [chemical binding]; other site 712938002025 catalytic site [active] 712938002026 domain IV; other site 712938002027 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 712938002028 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 712938002029 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 712938002030 active site 712938002031 catalytic residues [active] 712938002032 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 712938002033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 712938002034 ATP binding site [chemical binding]; other site 712938002035 Mg2+ binding site [ion binding]; other site 712938002036 G-X-G motif; other site 712938002037 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 712938002038 anchoring element; other site 712938002039 dimer interface [polypeptide binding]; other site 712938002040 ATP binding site [chemical binding]; other site 712938002041 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 712938002042 active site 712938002043 putative metal-binding site [ion binding]; other site 712938002044 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 712938002045 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 712938002046 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 712938002047 CAP-like domain; other site 712938002048 active site 712938002049 primary dimer interface [polypeptide binding]; other site 712938002050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 712938002051 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 712938002052 DHH family; Region: DHH; pfam01368 712938002053 DHHA2 domain; Region: DHHA2; pfam02833 712938002054 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 712938002055 cytosine deaminase; Provisional; Region: PRK09230 712938002056 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 712938002057 active site 712938002058 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 712938002059 active site 712938002060 metal-binding site [ion binding] 712938002061 nucleotide-binding site [chemical binding]; other site 712938002062 recombination factor protein RarA; Reviewed; Region: PRK13342 712938002063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712938002064 Walker A motif; other site 712938002065 ATP binding site [chemical binding]; other site 712938002066 Walker B motif; other site 712938002067 arginine finger; other site 712938002068 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 712938002069 Protein of unknown function (DUF554); Region: DUF554; pfam04474 712938002070 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 712938002071 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712938002072 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712938002073 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 712938002074 dimer interface [polypeptide binding]; other site 712938002075 H+/Cl- coupling transport residue; other site 712938002076 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 712938002077 Cl- binding residues [ion binding]; other site 712938002078 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 712938002079 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 712938002080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938002081 transaminase; Validated; Region: PRK07324 712938002082 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 712938002083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712938002084 homodimer interface [polypeptide binding]; other site 712938002085 catalytic residue [active] 712938002086 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 712938002087 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 712938002088 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 712938002089 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 712938002090 putative active site [active] 712938002091 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 712938002092 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 712938002093 active site 712938002094 catalytic tetrad [active] 712938002095 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 712938002096 substrate binding site [chemical binding]; other site 712938002097 ATP binding site [chemical binding]; other site 712938002098 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 712938002099 isocitrate dehydrogenase; Validated; Region: PRK06451 712938002100 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 712938002101 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 712938002102 active site 712938002103 DNA binding site [nucleotide binding] 712938002104 Int/Topo IB signature motif; other site 712938002105 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 712938002106 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 712938002107 active site 712938002108 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 712938002109 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 712938002110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712938002111 homodimer interface [polypeptide binding]; other site 712938002112 catalytic residue [active] 712938002113 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 712938002114 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 712938002115 putative NAD(P) binding site [chemical binding]; other site 712938002116 catalytic Zn binding site [ion binding]; other site 712938002117 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 712938002118 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 712938002119 putative NAD(P) binding site [chemical binding]; other site 712938002120 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 712938002121 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712938002122 Walker A/P-loop; other site 712938002123 ATP binding site [chemical binding]; other site 712938002124 Q-loop/lid; other site 712938002125 ABC transporter signature motif; other site 712938002126 Walker B; other site 712938002127 D-loop; other site 712938002128 H-loop/switch region; other site 712938002129 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 712938002130 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 712938002131 EamA-like transporter family; Region: EamA; pfam00892 712938002132 EamA-like transporter family; Region: EamA; pfam00892 712938002133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938002134 putative substrate translocation pore; other site 712938002135 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 712938002136 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 712938002137 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 712938002138 substrate binding site [chemical binding]; other site 712938002139 ligand binding site [chemical binding]; other site 712938002140 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 712938002141 tartrate dehydrogenase; Region: TTC; TIGR02089 712938002142 benzoate transport; Region: 2A0115; TIGR00895 712938002143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938002144 putative substrate translocation pore; other site 712938002145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938002146 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 712938002147 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 712938002148 substrate binding site [chemical binding]; other site 712938002149 oxyanion hole (OAH) forming residues; other site 712938002150 trimer interface [polypeptide binding]; other site 712938002151 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 712938002152 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 712938002153 acyl-activating enzyme (AAE) consensus motif; other site 712938002154 putative AMP binding site [chemical binding]; other site 712938002155 putative active site [active] 712938002156 putative CoA binding site [chemical binding]; other site 712938002157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938002158 D-galactonate transporter; Region: 2A0114; TIGR00893 712938002159 putative substrate translocation pore; other site 712938002160 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 712938002161 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 712938002162 tetramer interface [polypeptide binding]; other site 712938002163 catalytic Zn binding site [ion binding]; other site 712938002164 NADP binding site [chemical binding]; other site 712938002165 cystathionine beta-lyase; Provisional; Region: PRK07671 712938002166 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 712938002167 homodimer interface [polypeptide binding]; other site 712938002168 substrate-cofactor binding pocket; other site 712938002169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712938002170 catalytic residue [active] 712938002171 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 712938002172 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 712938002173 dimer interface [polypeptide binding]; other site 712938002174 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712938002175 catalytic residue [active] 712938002176 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 712938002177 Predicted transcriptional regulator [Transcription]; Region: COG2378 712938002178 HTH domain; Region: HTH_11; pfam08279 712938002179 WYL domain; Region: WYL; pfam13280 712938002180 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 712938002181 Helix-turn-helix domain; Region: HTH_38; pfam13936 712938002182 Homeodomain-like domain; Region: HTH_32; pfam13565 712938002183 Integrase core domain; Region: rve; pfam00665 712938002184 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 712938002185 EamA-like transporter family; Region: EamA; pfam00892 712938002186 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 712938002187 L-aspartate oxidase; Provisional; Region: PRK06175 712938002188 Transcriptional regulator [Transcription]; Region: LysR; COG0583 712938002189 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 712938002190 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 712938002191 dimerization interface [polypeptide binding]; other site 712938002192 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 712938002193 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 712938002194 active site 712938002195 nucleophile elbow; other site 712938002196 putative acyltransferase; Provisional; Region: PRK05790 712938002197 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 712938002198 dimer interface [polypeptide binding]; other site 712938002199 active site 712938002200 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 712938002201 Domain of unknown function DUF20; Region: UPF0118; pfam01594 712938002202 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 712938002203 Beta-lactamase; Region: Beta-lactamase; pfam00144 712938002204 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 712938002205 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 712938002206 putative active site [active] 712938002207 catalytic site [active] 712938002208 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712938002209 Walker A/P-loop; other site 712938002210 ATP binding site [chemical binding]; other site 712938002211 Q-loop/lid; other site 712938002212 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 712938002213 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 712938002214 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 712938002215 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 712938002216 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 712938002217 Peptidase family C69; Region: Peptidase_C69; cl17793 712938002218 TPR repeat; Region: TPR_11; pfam13414 712938002219 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 712938002220 Helix-turn-helix domain; Region: HTH_38; pfam13936 712938002221 Homeodomain-like domain; Region: HTH_32; pfam13565 712938002222 Integrase core domain; Region: rve; pfam00665 712938002223 putative transport protein YifK; Provisional; Region: PRK10746 712938002224 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 712938002225 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 712938002226 TPP-binding site; other site 712938002227 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 712938002228 PYR/PP interface [polypeptide binding]; other site 712938002229 dimer interface [polypeptide binding]; other site 712938002230 TPP binding site [chemical binding]; other site 712938002231 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 712938002232 AAA ATPase domain; Region: AAA_16; pfam13191 712938002233 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 712938002234 Uncharacterized conserved protein [Function unknown]; Region: COG3410 712938002235 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 712938002236 active site 712938002237 multimer interface [polypeptide binding]; other site 712938002238 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 712938002239 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 712938002240 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 712938002241 substrate binding pocket [chemical binding]; other site 712938002242 membrane-bound complex binding site; other site 712938002243 hinge residues; other site 712938002244 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 712938002245 aspartate aminotransferase; Provisional; Region: PRK05764 712938002246 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 712938002247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712938002248 homodimer interface [polypeptide binding]; other site 712938002249 catalytic residue [active] 712938002250 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 712938002251 guanine deaminase; Region: guan_deamin; TIGR02967 712938002252 active site 712938002253 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 712938002254 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 712938002255 metal binding site [ion binding]; metal-binding site 712938002256 dimer interface [polypeptide binding]; other site 712938002257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 712938002258 ABC transporter signature motif; other site 712938002259 Walker B; other site 712938002260 D-loop; other site 712938002261 H-loop/switch region; other site 712938002262 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 712938002263 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 712938002264 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 712938002265 TPP-binding site [chemical binding]; other site 712938002266 dimer interface [polypeptide binding]; other site 712938002267 GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439 712938002268 GIY-YIG motif/motif A; other site 712938002269 putative active site [active] 712938002270 putative metal binding site [ion binding]; other site 712938002271 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 712938002272 Uncharacterized conserved protein [Function unknown]; Region: COG3410 712938002273 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 712938002274 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 712938002275 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 712938002276 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 712938002277 ABC1 family; Region: ABC1; cl17513 712938002278 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 712938002279 Int/Topo IB signature motif; other site 712938002280 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938002281 MULE transposase domain; Region: MULE; pfam10551 712938002282 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 712938002283 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 712938002284 DNA-binding interface [nucleotide binding]; DNA binding site 712938002285 Integrase core domain; Region: rve; pfam00665 712938002286 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 712938002287 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 712938002288 ATP binding site [chemical binding]; other site 712938002289 putative Mg++ binding site [ion binding]; other site 712938002290 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 712938002291 nucleotide binding region [chemical binding]; other site 712938002292 ATP-binding site [chemical binding]; other site 712938002293 Integrase core domain; Region: rve; pfam00665 712938002294 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 712938002295 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 712938002296 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 712938002297 DNA methylase; Region: N6_N4_Mtase; pfam01555 712938002298 DNA methylase; Region: N6_N4_Mtase; pfam01555 712938002299 Helix-turn-helix domain; Region: HTH_19; pfam12844 712938002300 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 712938002301 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 712938002302 GntP family permease; Region: GntP_permease; pfam02447 712938002303 fructuronate transporter; Provisional; Region: PRK10034; cl15264 712938002304 aspartate aminotransferase; Provisional; Region: PRK05764 712938002305 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 712938002306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712938002307 homodimer interface [polypeptide binding]; other site 712938002308 catalytic residue [active] 712938002309 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 712938002310 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 712938002311 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 712938002312 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 712938002313 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 712938002314 molybdopterin cofactor binding site; other site 712938002315 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 712938002316 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 712938002317 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 712938002318 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 712938002319 molybdopterin cofactor binding site; other site 712938002320 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 712938002321 MPT binding site; other site 712938002322 trimer interface [polypeptide binding]; other site 712938002323 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 712938002324 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 712938002325 dimer interface [polypeptide binding]; other site 712938002326 putative functional site; other site 712938002327 putative MPT binding site; other site 712938002328 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 712938002329 Histidine kinase; Region: HisKA_3; pfam07730 712938002330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 712938002331 ATP binding site [chemical binding]; other site 712938002332 Mg2+ binding site [ion binding]; other site 712938002333 G-X-G motif; other site 712938002334 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 712938002335 non-specific DNA binding site [nucleotide binding]; other site 712938002336 salt bridge; other site 712938002337 sequence-specific DNA binding site [nucleotide binding]; other site 712938002338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 712938002339 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 712938002340 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 712938002341 FeS/SAM binding site; other site 712938002342 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 712938002343 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 712938002344 MoaD interaction [polypeptide binding]; other site 712938002345 active site residues [active] 712938002346 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 712938002347 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 712938002348 ABC-ATPase subunit interface; other site 712938002349 dimer interface [polypeptide binding]; other site 712938002350 putative PBP binding regions; other site 712938002351 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 712938002352 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 712938002353 Walker A/P-loop; other site 712938002354 ATP binding site [chemical binding]; other site 712938002355 Q-loop/lid; other site 712938002356 ABC transporter signature motif; other site 712938002357 Walker B; other site 712938002358 D-loop; other site 712938002359 H-loop/switch region; other site 712938002360 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 712938002361 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 712938002362 Uncharacterized conserved protein [Function unknown]; Region: COG2461 712938002363 Family of unknown function (DUF438); Region: DUF438; pfam04282 712938002364 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 712938002365 EamA-like transporter family; Region: EamA; cl17759 712938002366 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 712938002367 Helix-turn-helix domain; Region: HTH_38; pfam13936 712938002368 Integrase core domain; Region: rve; pfam00665 712938002369 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 712938002370 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 712938002371 putative ligand binding residues [chemical binding]; other site 712938002372 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 712938002373 FeS assembly protein SufB; Region: sufB; TIGR01980 712938002374 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 712938002375 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 712938002376 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 712938002377 catalytic residue [active] 712938002378 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 712938002379 FeS assembly protein SufD; Region: sufD; TIGR01981 712938002380 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 712938002381 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 712938002382 Walker A/P-loop; other site 712938002383 ATP binding site [chemical binding]; other site 712938002384 Q-loop/lid; other site 712938002385 ABC transporter signature motif; other site 712938002386 Walker B; other site 712938002387 D-loop; other site 712938002388 H-loop/switch region; other site 712938002389 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 712938002390 UbiA prenyltransferase family; Region: UbiA; pfam01040 712938002391 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 712938002392 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 712938002393 substrate binding pocket [chemical binding]; other site 712938002394 chain length determination region; other site 712938002395 substrate-Mg2+ binding site; other site 712938002396 catalytic residues [active] 712938002397 aspartate-rich region 1; other site 712938002398 active site lid residues [active] 712938002399 aspartate-rich region 2; other site 712938002400 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 712938002401 D-lactate dehydrogenase; Validated; Region: PRK08605 712938002402 homodimer interface [polypeptide binding]; other site 712938002403 ligand binding site [chemical binding]; other site 712938002404 NAD binding site [chemical binding]; other site 712938002405 catalytic site [active] 712938002406 aspartate aminotransferase; Provisional; Region: PRK06348 712938002407 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 712938002408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712938002409 homodimer interface [polypeptide binding]; other site 712938002410 catalytic residue [active] 712938002411 prephenate dehydrogenase; Validated; Region: PRK06545 712938002412 prephenate dehydrogenase; Validated; Region: PRK08507 712938002413 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 712938002414 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 712938002415 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 712938002416 hinge; other site 712938002417 active site 712938002418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938002419 Major Facilitator Superfamily; Region: MFS_1; pfam07690 712938002420 putative substrate translocation pore; other site 712938002421 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 712938002422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938002423 POT family; Region: PTR2; cl17359 712938002424 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 712938002425 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 712938002426 active site 712938002427 motif I; other site 712938002428 motif II; other site 712938002429 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 712938002430 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 712938002431 NADP binding site [chemical binding]; other site 712938002432 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 712938002433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938002434 Major Facilitator Superfamily; Region: MFS_1; pfam07690 712938002435 putative substrate translocation pore; other site 712938002436 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 712938002437 K+ potassium transporter; Region: K_trans; cl15781 712938002438 glycerol kinase; Provisional; Region: glpK; PRK00047 712938002439 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 712938002440 N- and C-terminal domain interface [polypeptide binding]; other site 712938002441 active site 712938002442 MgATP binding site [chemical binding]; other site 712938002443 catalytic site [active] 712938002444 metal binding site [ion binding]; metal-binding site 712938002445 glycerol binding site [chemical binding]; other site 712938002446 homotetramer interface [polypeptide binding]; other site 712938002447 homodimer interface [polypeptide binding]; other site 712938002448 FBP binding site [chemical binding]; other site 712938002449 protein IIAGlc interface [polypeptide binding]; other site 712938002450 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 712938002451 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 712938002452 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 712938002453 TrkA-N domain; Region: TrkA_N; pfam02254 712938002454 TrkA-C domain; Region: TrkA_C; pfam02080 712938002455 Peptidase family C69; Region: Peptidase_C69; pfam03577 712938002456 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 712938002457 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 712938002458 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 712938002459 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 712938002460 active site 712938002461 metal binding site [ion binding]; metal-binding site 712938002462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938002463 Major Facilitator Superfamily; Region: MFS_1; pfam07690 712938002464 putative substrate translocation pore; other site 712938002465 drug efflux system protein MdtG; Provisional; Region: PRK09874 712938002466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938002467 putative substrate translocation pore; other site 712938002468 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 712938002469 Domain of unknown function DUF21; Region: DUF21; pfam01595 712938002470 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 712938002471 Transporter associated domain; Region: CorC_HlyC; pfam03471 712938002472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938002473 putative substrate translocation pore; other site 712938002474 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 712938002475 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 712938002476 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 712938002477 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 712938002478 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 712938002479 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 712938002480 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 712938002481 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 712938002482 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 712938002483 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 712938002484 E3 interaction surface; other site 712938002485 lipoyl attachment site [posttranslational modification]; other site 712938002486 e3 binding domain; Region: E3_binding; pfam02817 712938002487 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 712938002488 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 712938002489 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 712938002490 alpha subunit interface [polypeptide binding]; other site 712938002491 TPP binding site [chemical binding]; other site 712938002492 heterodimer interface [polypeptide binding]; other site 712938002493 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 712938002494 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 712938002495 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 712938002496 tetramer interface [polypeptide binding]; other site 712938002497 TPP-binding site [chemical binding]; other site 712938002498 heterodimer interface [polypeptide binding]; other site 712938002499 phosphorylation loop region [posttranslational modification] 712938002500 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 712938002501 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 712938002502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712938002503 catalytic residue [active] 712938002504 homoserine dehydrogenase; Provisional; Region: PRK06349 712938002505 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 712938002506 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 712938002507 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 712938002508 homoserine kinase; Provisional; Region: PRK01212 712938002509 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 712938002510 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 712938002511 Protein of unknown function (DUF328); Region: DUF328; pfam03883 712938002512 EDD domain protein, DegV family; Region: DegV; TIGR00762 712938002513 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 712938002514 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 712938002515 Domain of unknown function (DUF814); Region: DUF814; pfam05670 712938002516 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712938002517 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712938002518 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938002519 MULE transposase domain; Region: MULE; pfam10551 712938002520 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 712938002521 arsenical-resistance protein; Region: acr3; TIGR00832 712938002522 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 712938002523 Helix-turn-helix domain; Region: HTH_38; pfam13936 712938002524 Integrase core domain; Region: rve; pfam00665 712938002525 Transcriptional regulator [Transcription]; Region: LysR; COG0583 712938002526 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 712938002527 LysR substrate binding domain; Region: LysR_substrate; pfam03466 712938002528 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 712938002529 Glutamine amidotransferase class-I; Region: GATase; pfam00117 712938002530 catalytic site [active] 712938002531 subunit interface [polypeptide binding]; other site 712938002532 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 712938002533 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 712938002534 substrate binding pocket [chemical binding]; other site 712938002535 membrane-bound complex binding site; other site 712938002536 hinge residues; other site 712938002537 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938002538 MULE transposase domain; Region: MULE; pfam10551 712938002539 putative transposase OrfB; Reviewed; Region: PHA02517 712938002540 HTH-like domain; Region: HTH_21; pfam13276 712938002541 Integrase core domain; Region: rve; pfam00665 712938002542 Integrase core domain; Region: rve_3; pfam13683 712938002543 HTH-like domain; Region: HTH_21; pfam13276 712938002544 Integrase core domain; Region: rve; pfam00665 712938002545 amidase; Provisional; Region: PRK06529 712938002546 Amidase; Region: Amidase; cl11426 712938002547 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 712938002548 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 712938002549 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 712938002550 Transglycosylase; Region: Transgly; pfam00912 712938002551 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 712938002552 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 712938002553 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 712938002554 EamA-like transporter family; Region: EamA; pfam00892 712938002555 EamA-like transporter family; Region: EamA; pfam00892 712938002556 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 712938002557 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 712938002558 active site 712938002559 catalytic tetrad [active] 712938002560 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 712938002561 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 712938002562 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 712938002563 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 712938002564 putative dimer interface [polypeptide binding]; other site 712938002565 putative anticodon binding site; other site 712938002566 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 712938002567 homodimer interface [polypeptide binding]; other site 712938002568 motif 1; other site 712938002569 motif 2; other site 712938002570 active site 712938002571 motif 3; other site 712938002572 diphosphomevalonate decarboxylase; Region: PLN02407 712938002573 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 712938002574 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 712938002575 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 712938002576 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 712938002577 Helix-turn-helix domain; Region: HTH_38; pfam13936 712938002578 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 712938002579 Q-loop/lid; other site 712938002580 ABC transporter signature motif; other site 712938002581 Walker B; other site 712938002582 D-loop; other site 712938002583 H-loop/switch region; other site 712938002584 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938002585 MULE transposase domain; Region: MULE; pfam10551 712938002586 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 712938002587 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 712938002588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 712938002589 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 712938002590 active site 712938002591 motif I; other site 712938002592 motif II; other site 712938002593 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 712938002594 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 712938002595 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 712938002596 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 712938002597 heterodimer interface [polypeptide binding]; other site 712938002598 active site 712938002599 FMN binding site [chemical binding]; other site 712938002600 homodimer interface [polypeptide binding]; other site 712938002601 substrate binding site [chemical binding]; other site 712938002602 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 712938002603 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 712938002604 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 712938002605 putative transposase OrfB; Reviewed; Region: PHA02517 712938002606 HTH-like domain; Region: HTH_21; pfam13276 712938002607 Integrase core domain; Region: rve; pfam00665 712938002608 Integrase core domain; Region: rve_3; pfam13683 712938002609 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 712938002610 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 712938002611 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 712938002612 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 712938002613 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 712938002614 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938002615 MULE transposase domain; Region: MULE; pfam10551 712938002616 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 712938002617 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 712938002618 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 712938002619 putative transposase OrfB; Reviewed; Region: PHA02517 712938002620 HTH-like domain; Region: HTH_21; pfam13276 712938002621 Integrase core domain; Region: rve; pfam00665 712938002622 Integrase core domain; Region: rve_3; pfam13683 712938002623 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712938002624 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712938002625 amino acid transporter; Region: 2A0306; TIGR00909 712938002626 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 712938002627 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 712938002628 RimM N-terminal domain; Region: RimM; pfam01782 712938002629 PRC-barrel domain; Region: PRC; pfam05239 712938002630 PhoU domain; Region: PhoU; pfam01895 712938002631 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 712938002632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 712938002633 dimer interface [polypeptide binding]; other site 712938002634 conserved gate region; other site 712938002635 putative PBP binding loops; other site 712938002636 ABC-ATPase subunit interface; other site 712938002637 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 712938002638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 712938002639 dimer interface [polypeptide binding]; other site 712938002640 conserved gate region; other site 712938002641 putative PBP binding loops; other site 712938002642 ABC-ATPase subunit interface; other site 712938002643 PBP superfamily domain; Region: PBP_like_2; cl17296 712938002644 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 712938002645 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 712938002646 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 712938002647 P loop; other site 712938002648 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 712938002649 ribonuclease III; Reviewed; Region: rnc; PRK00102 712938002650 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 712938002651 dimerization interface [polypeptide binding]; other site 712938002652 active site 712938002653 metal binding site [ion binding]; metal-binding site 712938002654 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 712938002655 dsRNA binding site [nucleotide binding]; other site 712938002656 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 712938002657 DAK2 domain; Region: Dak2; pfam02734 712938002658 GTPase RsgA; Reviewed; Region: PRK00098 712938002659 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 712938002660 RNA binding site [nucleotide binding]; other site 712938002661 homodimer interface [polypeptide binding]; other site 712938002662 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 712938002663 GTPase/Zn-binding domain interface [polypeptide binding]; other site 712938002664 GTP/Mg2+ binding site [chemical binding]; other site 712938002665 G4 box; other site 712938002666 G5 box; other site 712938002667 G1 box; other site 712938002668 Switch I region; other site 712938002669 G2 box; other site 712938002670 G3 box; other site 712938002671 Switch II region; other site 712938002672 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 712938002673 Catalytic domain of Protein Kinases; Region: PKc; cd00180 712938002674 active site 712938002675 ATP binding site [chemical binding]; other site 712938002676 substrate binding site [chemical binding]; other site 712938002677 activation loop (A-loop); other site 712938002678 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 712938002679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 712938002680 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 712938002681 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 712938002682 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 712938002683 16S rRNA methyltransferase B; Provisional; Region: PRK14902 712938002684 NusB family; Region: NusB; pfam01029 712938002685 putative RNA binding site [nucleotide binding]; other site 712938002686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 712938002687 S-adenosylmethionine binding site [chemical binding]; other site 712938002688 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 712938002689 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 712938002690 putative active site [active] 712938002691 substrate binding site [chemical binding]; other site 712938002692 putative cosubstrate binding site; other site 712938002693 catalytic site [active] 712938002694 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 712938002695 substrate binding site [chemical binding]; other site 712938002696 Flavoprotein; Region: Flavoprotein; cl08021 712938002697 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 712938002698 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 712938002699 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 712938002700 Walker A/P-loop; other site 712938002701 ATP binding site [chemical binding]; other site 712938002702 Q-loop/lid; other site 712938002703 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 712938002704 ABC transporter signature motif; other site 712938002705 Walker B; other site 712938002706 D-loop; other site 712938002707 H-loop/switch region; other site 712938002708 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 712938002709 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 712938002710 substrate binding pocket [chemical binding]; other site 712938002711 chain length determination region; other site 712938002712 substrate-Mg2+ binding site; other site 712938002713 catalytic residues [active] 712938002714 aspartate-rich region 1; other site 712938002715 active site lid residues [active] 712938002716 aspartate-rich region 2; other site 712938002717 Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601 712938002718 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 712938002719 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 712938002720 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 712938002721 homodimer interface [polypeptide binding]; other site 712938002722 NADP binding site [chemical binding]; other site 712938002723 substrate binding site [chemical binding]; other site 712938002724 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 712938002725 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 712938002726 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 712938002727 active site 712938002728 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 712938002729 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 712938002730 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 712938002731 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 712938002732 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 712938002733 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 712938002734 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 712938002735 nucleotide binding site [chemical binding]; other site 712938002736 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 712938002737 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 712938002738 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 712938002739 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 712938002740 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 712938002741 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 712938002742 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 712938002743 dimer interface [polypeptide binding]; other site 712938002744 motif 1; other site 712938002745 active site 712938002746 motif 2; other site 712938002747 motif 3; other site 712938002748 OxaA-like protein precursor; Provisional; Region: PRK02463 712938002749 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 712938002750 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 712938002751 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 712938002752 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 712938002753 HAMP domain; Region: HAMP; pfam00672 712938002754 dimerization interface [polypeptide binding]; other site 712938002755 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 712938002756 dimer interface [polypeptide binding]; other site 712938002757 phosphorylation site [posttranslational modification] 712938002758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 712938002759 ATP binding site [chemical binding]; other site 712938002760 Mg2+ binding site [ion binding]; other site 712938002761 G-X-G motif; other site 712938002762 hypothetical protein; Provisional; Region: PRK13670 712938002763 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 712938002764 GTPase YqeH; Provisional; Region: PRK13796 712938002765 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 712938002766 GTP/Mg2+ binding site [chemical binding]; other site 712938002767 G4 box; other site 712938002768 G5 box; other site 712938002769 G1 box; other site 712938002770 Switch I region; other site 712938002771 G2 box; other site 712938002772 G3 box; other site 712938002773 Switch II region; other site 712938002774 primosomal protein DnaI; Reviewed; Region: PRK08939 712938002775 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 712938002776 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712938002777 Walker A motif; other site 712938002778 ATP binding site [chemical binding]; other site 712938002779 Walker B motif; other site 712938002780 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 712938002781 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 712938002782 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 712938002783 DNA binding site [nucleotide binding] 712938002784 catalytic residue [active] 712938002785 H2TH interface [polypeptide binding]; other site 712938002786 putative catalytic residues [active] 712938002787 turnover-facilitating residue; other site 712938002788 intercalation triad [nucleotide binding]; other site 712938002789 8OG recognition residue [nucleotide binding]; other site 712938002790 putative reading head residues; other site 712938002791 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 712938002792 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 712938002793 DNA polymerase I; Provisional; Region: PRK05755 712938002794 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 712938002795 active site 712938002796 metal binding site 1 [ion binding]; metal-binding site 712938002797 putative 5' ssDNA interaction site; other site 712938002798 metal binding site 3; metal-binding site 712938002799 metal binding site 2 [ion binding]; metal-binding site 712938002800 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 712938002801 putative DNA binding site [nucleotide binding]; other site 712938002802 putative metal binding site [ion binding]; other site 712938002803 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 712938002804 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 712938002805 active site 712938002806 DNA binding site [nucleotide binding] 712938002807 catalytic site [active] 712938002808 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 712938002809 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 712938002810 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 712938002811 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 712938002812 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 712938002813 putative tRNA-binding site [nucleotide binding]; other site 712938002814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 712938002815 S-adenosylmethionine binding site [chemical binding]; other site 712938002816 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 712938002817 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 712938002818 SurA N-terminal domain; Region: SurA_N; pfam09312 712938002819 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 712938002820 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 712938002821 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 712938002822 generic binding surface II; other site 712938002823 generic binding surface I; other site 712938002824 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 712938002825 Zn2+ binding site [ion binding]; other site 712938002826 Mg2+ binding site [ion binding]; other site 712938002827 Protein of unknown function (DUF964); Region: DUF964; cl01483 712938002828 Transglycosylase; Region: Transgly; pfam00912 712938002829 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 712938002830 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 712938002831 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 712938002832 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 712938002833 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 712938002834 active site 712938002835 HIGH motif; other site 712938002836 KMSK motif region; other site 712938002837 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 712938002838 tRNA binding surface [nucleotide binding]; other site 712938002839 anticodon binding site; other site 712938002840 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 712938002841 dihydropteroate synthase; Region: DHPS; TIGR01496 712938002842 substrate binding pocket [chemical binding]; other site 712938002843 dimer interface [polypeptide binding]; other site 712938002844 inhibitor binding site; inhibition site 712938002845 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 712938002846 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 712938002847 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 712938002848 Transcriptional regulators [Transcription]; Region: PurR; COG1609 712938002849 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 712938002850 DNA binding site [nucleotide binding] 712938002851 domain linker motif; other site 712938002852 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 712938002853 dimerization interface [polypeptide binding]; other site 712938002854 ligand binding site [chemical binding]; other site 712938002855 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 712938002856 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 712938002857 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 712938002858 dipeptidase PepV; Reviewed; Region: PRK07318 712938002859 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 712938002860 active site 712938002861 metal binding site [ion binding]; metal-binding site 712938002862 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 712938002863 putative substrate binding site [chemical binding]; other site 712938002864 putative ATP binding site [chemical binding]; other site 712938002865 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 712938002866 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 712938002867 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 712938002868 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 712938002869 HIGH motif; other site 712938002870 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 712938002871 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 712938002872 active site 712938002873 KMSKS motif; other site 712938002874 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 712938002875 tRNA binding surface [nucleotide binding]; other site 712938002876 S-adenosylmethionine synthetase; Validated; Region: PRK05250 712938002877 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 712938002878 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 712938002879 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 712938002880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938002881 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 712938002882 putative substrate translocation pore; other site 712938002883 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 712938002884 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 712938002885 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 712938002886 catalytic Zn binding site [ion binding]; other site 712938002887 NADP binding site [chemical binding]; other site 712938002888 xanthine permease; Region: pbuX; TIGR03173 712938002889 transglutaminase; Provisional; Region: tgl; PRK03187 712938002890 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 712938002891 Class III ribonucleotide reductase; Region: RNR_III; cd01675 712938002892 effector binding site; other site 712938002893 active site 712938002894 Zn binding site [ion binding]; other site 712938002895 glycine loop; other site 712938002896 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 712938002897 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 712938002898 substrate binding pocket [chemical binding]; other site 712938002899 membrane-bound complex binding site; other site 712938002900 hinge residues; other site 712938002901 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 712938002902 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 712938002903 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 712938002904 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 712938002905 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 712938002906 putative ADP-binding pocket [chemical binding]; other site 712938002907 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 712938002908 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 712938002909 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 712938002910 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 712938002911 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 712938002912 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 712938002913 active site 712938002914 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 712938002915 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 712938002916 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 712938002917 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 712938002918 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 712938002919 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 712938002920 Walker A/P-loop; other site 712938002921 ATP binding site [chemical binding]; other site 712938002922 Q-loop/lid; other site 712938002923 ABC transporter signature motif; other site 712938002924 Walker B; other site 712938002925 D-loop; other site 712938002926 H-loop/switch region; other site 712938002927 Predicted transcriptional regulators [Transcription]; Region: COG1725 712938002928 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 712938002929 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 712938002930 NAD binding site [chemical binding]; other site 712938002931 substrate binding site [chemical binding]; other site 712938002932 homodimer interface [polypeptide binding]; other site 712938002933 active site 712938002934 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 712938002935 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 712938002936 active site 712938002937 Predicted integral membrane protein [Function unknown]; Region: COG5617 712938002938 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 712938002939 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 712938002940 G1 box; other site 712938002941 putative GEF interaction site [polypeptide binding]; other site 712938002942 GTP/Mg2+ binding site [chemical binding]; other site 712938002943 Switch I region; other site 712938002944 G2 box; other site 712938002945 G3 box; other site 712938002946 Switch II region; other site 712938002947 G4 box; other site 712938002948 G5 box; other site 712938002949 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 712938002950 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 712938002951 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 712938002952 Ligand binding site; other site 712938002953 Putative Catalytic site; other site 712938002954 DXD motif; other site 712938002955 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 712938002956 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 712938002957 Putative Catalytic site; other site 712938002958 DXD motif; other site 712938002959 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 712938002960 Domain of unknown function DUF20; Region: UPF0118; pfam01594 712938002961 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 712938002962 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 712938002963 Ligand binding site; other site 712938002964 Putative Catalytic site; other site 712938002965 DXD motif; other site 712938002966 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 712938002967 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 712938002968 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 712938002969 NlpC/P60 family; Region: NLPC_P60; pfam00877 712938002970 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 712938002971 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 712938002972 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 712938002973 Acyltransferase family; Region: Acyl_transf_3; pfam01757 712938002974 putative glycosyl transferase; Provisional; Region: PRK10073 712938002975 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 712938002976 active site 712938002977 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 712938002978 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 712938002979 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 712938002980 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 712938002981 putative ADP-binding pocket [chemical binding]; other site 712938002982 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 712938002983 Helix-turn-helix domain; Region: HTH_38; pfam13936 712938002984 Integrase core domain; Region: rve; pfam00665 712938002985 putative transposase OrfB; Reviewed; Region: PHA02517 712938002986 HTH-like domain; Region: HTH_21; pfam13276 712938002987 Integrase core domain; Region: rve; pfam00665 712938002988 Integrase core domain; Region: rve_2; pfam13333 712938002989 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938002990 MULE transposase domain; Region: MULE; pfam10551 712938002991 putative transposase OrfB; Reviewed; Region: PHA02517 712938002992 HTH-like domain; Region: HTH_21; pfam13276 712938002993 Integrase core domain; Region: rve; pfam00665 712938002994 Integrase core domain; Region: rve_3; pfam13683 712938002995 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 712938002996 recombination regulator RecX; Provisional; Region: recX; PRK14135 712938002997 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 712938002998 Sulfatase; Region: Sulfatase; cl17466 712938002999 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 712938003000 active site 712938003001 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 712938003002 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 712938003003 ATP binding site [chemical binding]; other site 712938003004 putative Mg++ binding site [ion binding]; other site 712938003005 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 712938003006 nucleotide binding region [chemical binding]; other site 712938003007 ATP-binding site [chemical binding]; other site 712938003008 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 712938003009 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 712938003010 NAD(P) binding site [chemical binding]; other site 712938003011 LDH/MDH dimer interface [polypeptide binding]; other site 712938003012 substrate binding site [chemical binding]; other site 712938003013 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 712938003014 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 712938003015 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 712938003016 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 712938003017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712938003018 Walker A/P-loop; other site 712938003019 ATP binding site [chemical binding]; other site 712938003020 ABC transporter signature motif; other site 712938003021 Walker B; other site 712938003022 D-loop; other site 712938003023 H-loop/switch region; other site 712938003024 ABC transporter; Region: ABC_tran_2; pfam12848 712938003025 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 712938003026 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 712938003027 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 712938003028 dimerization interface [polypeptide binding]; other site 712938003029 putative DNA binding site [nucleotide binding]; other site 712938003030 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 712938003031 putative Zn2+ binding site [ion binding]; other site 712938003032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938003033 putative substrate translocation pore; other site 712938003034 Major Facilitator Superfamily; Region: MFS_1; pfam07690 712938003035 multicopper oxidase; Provisional; Region: PRK10965 712938003036 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 712938003037 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 712938003038 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 712938003039 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 712938003040 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 712938003041 HTH-like domain; Region: HTH_21; pfam13276 712938003042 Integrase core domain; Region: rve; pfam00665 712938003043 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938003044 MULE transposase domain; Region: MULE; pfam10551 712938003045 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 712938003046 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 712938003047 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 712938003048 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 712938003049 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938003050 MULE transposase domain; Region: MULE; pfam10551 712938003051 putative transposase OrfB; Reviewed; Region: PHA02517 712938003052 HTH-like domain; Region: HTH_21; pfam13276 712938003053 Integrase core domain; Region: rve; pfam00665 712938003054 Integrase core domain; Region: rve_3; pfam13683 712938003055 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 712938003056 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 712938003057 Soluble P-type ATPase [General function prediction only]; Region: COG4087 712938003058 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 712938003059 Integrase core domain; Region: rve; pfam00665 712938003060 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938003061 MULE transposase domain; Region: MULE; pfam10551 712938003062 TRAM domain; Region: TRAM; cl01282 712938003063 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 712938003064 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 712938003065 S-adenosylmethionine binding site [chemical binding]; other site 712938003066 putative lipid kinase; Reviewed; Region: PRK13055 712938003067 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 712938003068 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 712938003069 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 712938003070 GatB domain; Region: GatB_Yqey; smart00845 712938003071 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 712938003072 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 712938003073 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 712938003074 putative dimer interface [polypeptide binding]; other site 712938003075 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 712938003076 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 712938003077 putative dimer interface [polypeptide binding]; other site 712938003078 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 712938003079 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 712938003080 nucleotide binding pocket [chemical binding]; other site 712938003081 K-X-D-G motif; other site 712938003082 catalytic site [active] 712938003083 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 712938003084 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 712938003085 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 712938003086 Dimer interface [polypeptide binding]; other site 712938003087 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 712938003088 Part of AAA domain; Region: AAA_19; pfam13245 712938003089 Family description; Region: UvrD_C_2; pfam13538 712938003090 ATP-grasp domain; Region: ATP-grasp_4; cl17255 712938003091 acetoin reductase; Validated; Region: PRK08643 712938003092 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 712938003093 NAD binding site [chemical binding]; other site 712938003094 homotetramer interface [polypeptide binding]; other site 712938003095 homodimer interface [polypeptide binding]; other site 712938003096 active site 712938003097 substrate binding site [chemical binding]; other site 712938003098 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 712938003099 putative catalytic site [active] 712938003100 putative metal binding site [ion binding]; other site 712938003101 putative phosphate binding site [ion binding]; other site 712938003102 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 712938003103 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13641 712938003104 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 712938003105 Walker A/P-loop; other site 712938003106 ATP binding site [chemical binding]; other site 712938003107 Q-loop/lid; other site 712938003108 ABC transporter signature motif; other site 712938003109 Walker B; other site 712938003110 D-loop; other site 712938003111 H-loop/switch region; other site 712938003112 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 712938003113 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 712938003114 Walker A/P-loop; other site 712938003115 ATP binding site [chemical binding]; other site 712938003116 Q-loop/lid; other site 712938003117 ABC transporter signature motif; other site 712938003118 Walker B; other site 712938003119 D-loop; other site 712938003120 H-loop/switch region; other site 712938003121 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 712938003122 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 712938003123 alphaNTD homodimer interface [polypeptide binding]; other site 712938003124 alphaNTD - beta interaction site [polypeptide binding]; other site 712938003125 alphaNTD - beta' interaction site [polypeptide binding]; other site 712938003126 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 712938003127 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 712938003128 SecY translocase; Region: SecY; pfam00344 712938003129 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 712938003130 23S rRNA interface [nucleotide binding]; other site 712938003131 putative translocon interaction site; other site 712938003132 signal recognition particle (SRP54) interaction site; other site 712938003133 L23 interface [polypeptide binding]; other site 712938003134 trigger factor interaction site; other site 712938003135 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 712938003136 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 712938003137 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 712938003138 elongation factor G; Reviewed; Region: PRK12739 712938003139 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 712938003140 G1 box; other site 712938003141 putative GEF interaction site [polypeptide binding]; other site 712938003142 GTP/Mg2+ binding site [chemical binding]; other site 712938003143 Switch I region; other site 712938003144 G2 box; other site 712938003145 G3 box; other site 712938003146 Switch II region; other site 712938003147 G4 box; other site 712938003148 G5 box; other site 712938003149 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 712938003150 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 712938003151 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 712938003152 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 712938003153 Predicted membrane protein [Function unknown]; Region: COG3371 712938003154 Protein of unknown function (DUF998); Region: DUF998; pfam06197 712938003155 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 712938003156 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 712938003157 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 712938003158 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 712938003159 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 712938003160 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 712938003161 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 712938003162 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 712938003163 DNA binding site [nucleotide binding] 712938003164 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 712938003165 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 712938003166 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 712938003167 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 712938003168 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 712938003169 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 712938003170 RPB1 interaction site [polypeptide binding]; other site 712938003171 RPB12 interaction site [polypeptide binding]; other site 712938003172 RPB10 interaction site [polypeptide binding]; other site 712938003173 RPB11 interaction site [polypeptide binding]; other site 712938003174 RPB3 interaction site [polypeptide binding]; other site 712938003175 RPB12 interaction site [polypeptide binding]; other site 712938003176 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 712938003177 Clp amino terminal domain; Region: Clp_N; pfam02861 712938003178 Clp amino terminal domain; Region: Clp_N; pfam02861 712938003179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712938003180 Walker A motif; other site 712938003181 ATP binding site [chemical binding]; other site 712938003182 Walker B motif; other site 712938003183 arginine finger; other site 712938003184 UvrB/uvrC motif; Region: UVR; pfam02151 712938003185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712938003186 Walker A motif; other site 712938003187 ATP binding site [chemical binding]; other site 712938003188 Walker B motif; other site 712938003189 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 712938003190 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 712938003191 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 712938003192 NAD binding site [chemical binding]; other site 712938003193 substrate binding site [chemical binding]; other site 712938003194 catalytic Zn binding site [ion binding]; other site 712938003195 tetramer interface [polypeptide binding]; other site 712938003196 structural Zn binding site [ion binding]; other site 712938003197 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 712938003198 Integrase core domain; Region: rve; pfam00665 712938003199 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 712938003200 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 712938003201 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 712938003202 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 712938003203 Uncharacterized conserved protein [Function unknown]; Region: COG2966 712938003204 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 712938003205 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 712938003206 DNA-binding site [nucleotide binding]; DNA binding site 712938003207 RNA-binding motif; other site 712938003208 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 712938003209 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 712938003210 CAAX protease self-immunity; Region: Abi; pfam02517 712938003211 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 712938003212 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 712938003213 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 712938003214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938003215 Major Facilitator Superfamily; Region: MFS_1; pfam07690 712938003216 putative substrate translocation pore; other site 712938003217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938003218 L-arabinose isomerase; Provisional; Region: PRK02929 712938003219 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 712938003220 hexamer (dimer of trimers) interface [polypeptide binding]; other site 712938003221 substrate binding site [chemical binding]; other site 712938003222 trimer interface [polypeptide binding]; other site 712938003223 Mn binding site [ion binding]; other site 712938003224 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 712938003225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938003226 putative substrate translocation pore; other site 712938003227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938003228 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 712938003229 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 712938003230 DNA-binding site [nucleotide binding]; DNA binding site 712938003231 Transcriptional regulators [Transcription]; Region: PurR; COG1609 712938003232 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 712938003233 putative dimerization interface [polypeptide binding]; other site 712938003234 putative ligand binding site [chemical binding]; other site 712938003235 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 712938003236 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 712938003237 putative N- and C-terminal domain interface [polypeptide binding]; other site 712938003238 putative active site [active] 712938003239 MgATP binding site [chemical binding]; other site 712938003240 catalytic site [active] 712938003241 metal binding site [ion binding]; metal-binding site 712938003242 putative carbohydrate binding site [chemical binding]; other site 712938003243 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 712938003244 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 712938003245 active site 712938003246 Predicted integral membrane protein [Function unknown]; Region: COG0392 712938003247 Uncharacterized conserved protein [Function unknown]; Region: COG2898 712938003248 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 712938003249 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 712938003250 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 712938003251 Uncharacterized conserved protein [Function unknown]; Region: COG2966 712938003252 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 712938003253 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 712938003254 Transcriptional regulator [Transcription]; Region: LysR; COG0583 712938003255 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 712938003256 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 712938003257 dimerization interface [polypeptide binding]; other site 712938003258 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938003259 MULE transposase domain; Region: MULE; pfam10551 712938003260 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938003261 MULE transposase domain; Region: MULE; pfam10551 712938003262 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 712938003263 Integrase core domain; Region: rve; pfam00665 712938003264 HTH-like domain; Region: HTH_21; pfam13276 712938003265 Integrase core domain; Region: rve; pfam00665 712938003266 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 712938003267 Helix-turn-helix domain; Region: HTH_38; pfam13936 712938003268 Integrase core domain; Region: rve; pfam00665 712938003269 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 712938003270 Helix-turn-helix domain; Region: HTH_38; pfam13936 712938003271 Integrase core domain; Region: rve; pfam00665 712938003272 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 712938003273 active site 712938003274 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 712938003275 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 712938003276 active site turn [active] 712938003277 phosphorylation site [posttranslational modification] 712938003278 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 712938003279 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 712938003280 HPr interaction site; other site 712938003281 glycerol kinase (GK) interaction site [polypeptide binding]; other site 712938003282 active site 712938003283 phosphorylation site [posttranslational modification] 712938003284 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 712938003285 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 712938003286 putative NAD(P) binding site [chemical binding]; other site 712938003287 putative substrate binding site [chemical binding]; other site 712938003288 catalytic Zn binding site [ion binding]; other site 712938003289 structural Zn binding site [ion binding]; other site 712938003290 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 712938003291 active site 712938003292 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 712938003293 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 712938003294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 712938003295 Transcriptional regulator [Transcription]; Region: LysR; COG0583 712938003296 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 712938003297 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 712938003298 dimerization interface [polypeptide binding]; other site 712938003299 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 712938003300 inner membrane transporter YjeM; Provisional; Region: PRK15238 712938003301 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 712938003302 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 712938003303 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 712938003304 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 712938003305 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 712938003306 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 712938003307 PLD-like domain; Region: PLDc_2; pfam13091 712938003308 putative homodimer interface [polypeptide binding]; other site 712938003309 putative active site [active] 712938003310 catalytic site [active] 712938003311 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 712938003312 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 712938003313 ATP binding site [chemical binding]; other site 712938003314 putative Mg++ binding site [ion binding]; other site 712938003315 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 712938003316 nucleotide binding region [chemical binding]; other site 712938003317 ATP-binding site [chemical binding]; other site 712938003318 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 712938003319 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 712938003320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938003321 putative substrate translocation pore; other site 712938003322 Predicted transcriptional regulator [Transcription]; Region: COG2378 712938003323 WYL domain; Region: WYL; pfam13280 712938003324 S-ribosylhomocysteinase; Provisional; Region: PRK02260 712938003325 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 712938003326 substrate binding site [chemical binding]; other site 712938003327 THF binding site; other site 712938003328 zinc-binding site [ion binding]; other site 712938003329 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 712938003330 dimer interface [polypeptide binding]; other site 712938003331 active site 712938003332 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 712938003333 Y-family of DNA polymerases; Region: PolY; cl12025 712938003334 active site 712938003335 DNA binding site [nucleotide binding] 712938003336 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 712938003337 ATP-grasp domain; Region: ATP-grasp_4; cl17255 712938003338 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 712938003339 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 712938003340 putative active site [active] 712938003341 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 712938003342 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 712938003343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938003344 Major Facilitator Superfamily; Region: MFS_1; pfam07690 712938003345 putative substrate translocation pore; other site 712938003346 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 712938003347 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 712938003348 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 712938003349 Membrane transport protein; Region: Mem_trans; cl09117 712938003350 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 712938003351 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 712938003352 Probable transposase; Region: OrfB_IS605; pfam01385 712938003353 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 712938003354 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 712938003355 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 712938003356 inhibitor-cofactor binding pocket; inhibition site 712938003357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 712938003358 catalytic residue [active] 712938003359 amino acid transporter; Region: 2A0306; TIGR00909 712938003360 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 712938003361 argininosuccinate lyase; Provisional; Region: PRK00855 712938003362 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 712938003363 active sites [active] 712938003364 tetramer interface [polypeptide binding]; other site 712938003365 argininosuccinate synthase; Provisional; Region: PRK13820 712938003366 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 712938003367 ANP binding site [chemical binding]; other site 712938003368 Substrate Binding Site II [chemical binding]; other site 712938003369 Substrate Binding Site I [chemical binding]; other site 712938003370 conserved hypothetical integral membrane protein; Region: TIGR03766 712938003371 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 712938003372 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 712938003373 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 712938003374 Walker A/P-loop; other site 712938003375 ATP binding site [chemical binding]; other site 712938003376 Q-loop/lid; other site 712938003377 ABC transporter signature motif; other site 712938003378 Walker B; other site 712938003379 D-loop; other site 712938003380 H-loop/switch region; other site 712938003381 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 712938003382 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 712938003383 FtsX-like permease family; Region: FtsX; pfam02687 712938003384 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 712938003385 TPP-binding site; other site 712938003386 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 712938003387 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 712938003388 Probable transposase; Region: OrfB_IS605; pfam01385 712938003389 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 712938003390 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 712938003391 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 712938003392 FMN binding site [chemical binding]; other site 712938003393 substrate binding site [chemical binding]; other site 712938003394 putative catalytic residue [active] 712938003395 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 712938003396 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 712938003397 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 712938003398 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 712938003399 Soluble P-type ATPase [General function prediction only]; Region: COG4087 712938003400 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 712938003401 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 712938003402 GMP synthase; Reviewed; Region: guaA; PRK00074 712938003403 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 712938003404 AMP/PPi binding site [chemical binding]; other site 712938003405 candidate oxyanion hole; other site 712938003406 catalytic triad [active] 712938003407 potential glutamine specificity residues [chemical binding]; other site 712938003408 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 712938003409 ATP Binding subdomain [chemical binding]; other site 712938003410 Ligand Binding sites [chemical binding]; other site 712938003411 Dimerization subdomain; other site 712938003412 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938003413 MULE transposase domain; Region: MULE; pfam10551 712938003414 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 712938003415 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 712938003416 dimer interface [polypeptide binding]; other site 712938003417 phosphorylation site [posttranslational modification] 712938003418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 712938003419 ATP binding site [chemical binding]; other site 712938003420 Mg2+ binding site [ion binding]; other site 712938003421 G-X-G motif; other site 712938003422 pantothenate kinase; Provisional; Region: PRK05439 712938003423 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 712938003424 ATP-binding site [chemical binding]; other site 712938003425 CoA-binding site [chemical binding]; other site 712938003426 Mg2+-binding site [ion binding]; other site 712938003427 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 712938003428 Sulfatase; Region: Sulfatase; pfam00884 712938003429 EamA-like transporter family; Region: EamA; pfam00892 712938003430 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 712938003431 EamA-like transporter family; Region: EamA; pfam00892 712938003432 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 712938003433 Part of AAA domain; Region: AAA_19; pfam13245 712938003434 Family description; Region: UvrD_C_2; pfam13538 712938003435 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 712938003436 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 712938003437 HflX GTPase family; Region: HflX; cd01878 712938003438 G1 box; other site 712938003439 GTP/Mg2+ binding site [chemical binding]; other site 712938003440 Switch I region; other site 712938003441 G2 box; other site 712938003442 G3 box; other site 712938003443 Switch II region; other site 712938003444 G4 box; other site 712938003445 G5 box; other site 712938003446 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 712938003447 metal binding site [ion binding]; metal-binding site 712938003448 substrate binding pocket [chemical binding]; other site 712938003449 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 712938003450 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 712938003451 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 712938003452 Predicted membrane protein [Function unknown]; Region: COG1511 712938003453 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 712938003454 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 712938003455 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 712938003456 active site 712938003457 catalytic residues [active] 712938003458 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 712938003459 metal binding site 1 [ion binding]; metal-binding site 712938003460 metal binding site 2 [ion binding]; metal-binding site 712938003461 dimer interface [polypeptide binding]; other site 712938003462 structural Zn2+ binding site [ion binding]; other site 712938003463 amino acid transporter; Region: 2A0306; TIGR00909 712938003464 Spore germination protein; Region: Spore_permease; cl17796 712938003465 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 712938003466 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 712938003467 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696 712938003468 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 712938003469 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 712938003470 TAP-like protein; Region: Abhydrolase_4; pfam08386 712938003471 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 712938003472 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 712938003473 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 712938003474 dimer interface [polypeptide binding]; other site 712938003475 putative radical transfer pathway; other site 712938003476 diiron center [ion binding]; other site 712938003477 tyrosyl radical; other site 712938003478 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 712938003479 dinuclear metal binding motif [ion binding]; other site 712938003480 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 712938003481 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 712938003482 Class I ribonucleotide reductase; Region: RNR_I; cd01679 712938003483 active site 712938003484 dimer interface [polypeptide binding]; other site 712938003485 catalytic residues [active] 712938003486 effector binding site; other site 712938003487 R2 peptide binding site; other site 712938003488 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 712938003489 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 712938003490 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712938003491 Walker A/P-loop; other site 712938003492 ATP binding site [chemical binding]; other site 712938003493 Q-loop/lid; other site 712938003494 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 712938003495 ABC transporter signature motif; other site 712938003496 Walker B; other site 712938003497 D-loop; other site 712938003498 ABC transporter; Region: ABC_tran_2; pfam12848 712938003499 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 712938003500 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 712938003501 zinc binding site [ion binding]; other site 712938003502 putative ligand binding site [chemical binding]; other site 712938003503 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 712938003504 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 712938003505 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 712938003506 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 712938003507 ROK family; Region: ROK; pfam00480 712938003508 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 712938003509 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 712938003510 active site 712938003511 dimer interface [polypeptide binding]; other site 712938003512 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 712938003513 dimer interface [polypeptide binding]; other site 712938003514 active site 712938003515 Transcriptional regulators [Transcription]; Region: PurR; COG1609 712938003516 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 712938003517 DNA binding site [nucleotide binding] 712938003518 domain linker motif; other site 712938003519 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 712938003520 dimerization interface [polypeptide binding]; other site 712938003521 ligand binding site [chemical binding]; other site 712938003522 sodium binding site [ion binding]; other site 712938003523 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 712938003524 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 712938003525 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 712938003526 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 712938003527 dimer interface [polypeptide binding]; other site 712938003528 substrate binding site [chemical binding]; other site 712938003529 ATP binding site [chemical binding]; other site 712938003530 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 712938003531 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 712938003532 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 712938003533 active site 712938003534 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 712938003535 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 712938003536 Cl binding site [ion binding]; other site 712938003537 oligomer interface [polypeptide binding]; other site 712938003538 xanthine permease; Region: pbuX; TIGR03173 712938003539 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 712938003540 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 712938003541 NAD(P) binding site [chemical binding]; other site 712938003542 active site 712938003543 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 712938003544 catalytic core [active] 712938003545 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 712938003546 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 712938003547 Sulfatase; Region: Sulfatase; pfam00884 712938003548 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 712938003549 metal-binding site [ion binding] 712938003550 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 712938003551 Soluble P-type ATPase [General function prediction only]; Region: COG4087 712938003552 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 712938003553 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 712938003554 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 712938003555 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 712938003556 active site 712938003557 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 712938003558 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 712938003559 Walker A/P-loop; other site 712938003560 ATP binding site [chemical binding]; other site 712938003561 Q-loop/lid; other site 712938003562 ABC transporter signature motif; other site 712938003563 Walker B; other site 712938003564 D-loop; other site 712938003565 H-loop/switch region; other site 712938003566 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 712938003567 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 712938003568 Walker A/P-loop; other site 712938003569 ATP binding site [chemical binding]; other site 712938003570 Q-loop/lid; other site 712938003571 ABC transporter signature motif; other site 712938003572 Walker B; other site 712938003573 D-loop; other site 712938003574 H-loop/switch region; other site 712938003575 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 712938003576 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 712938003577 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 712938003578 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 712938003579 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 712938003580 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 712938003581 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 712938003582 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 712938003583 HflC protein; Region: hflC; TIGR01932 712938003584 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 712938003585 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 712938003586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938003587 putative substrate translocation pore; other site 712938003588 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 712938003589 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 712938003590 TPP-binding site [chemical binding]; other site 712938003591 dimer interface [polypeptide binding]; other site 712938003592 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 712938003593 PYR/PP interface [polypeptide binding]; other site 712938003594 dimer interface [polypeptide binding]; other site 712938003595 TPP binding site [chemical binding]; other site 712938003596 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 712938003597 putative translaldolase; Provisional; Region: PRK12376 712938003598 catalytic residue [active] 712938003599 putative transposase OrfB; Reviewed; Region: PHA02517 712938003600 HTH-like domain; Region: HTH_21; pfam13276 712938003601 Integrase core domain; Region: rve; pfam00665 712938003602 Integrase core domain; Region: rve_2; pfam13333 712938003603 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712938003604 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712938003605 HTH-like domain; Region: HTH_21; pfam13276 712938003606 Integrase core domain; Region: rve; pfam00665 712938003607 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 712938003608 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 712938003609 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 712938003610 Ligand Binding Site [chemical binding]; other site 712938003611 Protein of unknown function DUF111; Region: DUF111; cl03398 712938003612 Protein of unknown function DUF111; Region: DUF111; pfam01969 712938003613 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 712938003614 AIR carboxylase; Region: AIRC; smart01001 712938003615 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 712938003616 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938003617 MULE transposase domain; Region: MULE; pfam10551 712938003618 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 712938003619 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 712938003620 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 712938003621 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 712938003622 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 712938003623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938003624 putative substrate translocation pore; other site 712938003625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938003626 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 712938003627 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 712938003628 substrate binding site [chemical binding]; other site 712938003629 dimer interface [polypeptide binding]; other site 712938003630 ATP binding site [chemical binding]; other site 712938003631 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 712938003632 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 712938003633 DNA-binding interface [nucleotide binding]; DNA binding site 712938003634 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 712938003635 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 712938003636 active site 712938003637 catalytic residues [active] 712938003638 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 712938003639 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 712938003640 substrate binding site [chemical binding]; other site 712938003641 dimer interface [polypeptide binding]; other site 712938003642 ATP binding site [chemical binding]; other site 712938003643 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 712938003644 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 712938003645 Transcriptional regulators [Transcription]; Region: PurR; COG1609 712938003646 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 712938003647 DNA binding site [nucleotide binding] 712938003648 domain linker motif; other site 712938003649 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 712938003650 inner membrane transporter YjeM; Provisional; Region: PRK15238 712938003651 putative phosphoketolase; Provisional; Region: PRK05261 712938003652 XFP N-terminal domain; Region: XFP_N; pfam09364 712938003653 XFP C-terminal domain; Region: XFP_C; pfam09363 712938003654 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 712938003655 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 712938003656 active site 712938003657 motif I; other site 712938003658 motif II; other site 712938003659 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 712938003660 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 712938003661 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 712938003662 DNA-binding site [nucleotide binding]; DNA binding site 712938003663 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 712938003664 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 712938003665 putative deacylase active site [active] 712938003666 Peptidase family C69; Region: Peptidase_C69; pfam03577 712938003667 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 712938003668 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 712938003669 Domain of unknown function DUF21; Region: DUF21; pfam01595 712938003670 FOG: CBS domain [General function prediction only]; Region: COG0517 712938003671 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 712938003672 Transporter associated domain; Region: CorC_HlyC; smart01091 712938003673 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 712938003674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 712938003675 putative substrate translocation pore; other site 712938003676 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 712938003677 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 712938003678 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 712938003679 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 712938003680 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 712938003681 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 712938003682 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 712938003683 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 712938003684 NADP binding site [chemical binding]; other site 712938003685 homodimer interface [polypeptide binding]; other site 712938003686 active site 712938003687 oligoendopeptidase F; Region: pepF; TIGR00181 712938003688 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 712938003689 active site 712938003690 Zn binding site [ion binding]; other site 712938003691 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 712938003692 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 712938003693 D-lactate dehydrogenase; Provisional; Region: PRK11183 712938003694 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 712938003695 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938003696 MULE transposase domain; Region: MULE; pfam10551 712938003697 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 712938003698 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 712938003699 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 712938003700 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 712938003701 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 712938003702 Melibiase; Region: Melibiase; pfam02065 712938003703 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938003704 MULE transposase domain; Region: MULE; pfam10551 712938003705 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938003706 MULE transposase domain; Region: MULE; pfam10551 712938003707 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 712938003708 Helix-turn-helix domain; Region: HTH_38; pfam13936 712938003709 Integrase core domain; Region: rve; pfam00665 712938003710 Predicted helicase [General function prediction only]; Region: COG4889 712938003711 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938003712 MULE transposase domain; Region: MULE; pfam10551 712938003713 Transposase, Mutator family; Region: Transposase_mut; pfam00872 712938003714 MULE transposase domain; Region: MULE; pfam10551 712938003715 HTH-like domain; Region: HTH_21; pfam13276 712938003716 Integrase core domain; Region: rve; pfam00665 712938003717 Integrase core domain; Region: rve; pfam00665 712938003718 Transcriptional regulators [Transcription]; Region: PurR; COG1609 712938003719 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 712938003720 DNA binding site [nucleotide binding] 712938003721 domain linker motif; other site 712938003722 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 712938003723 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 712938003724 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 712938003725 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 712938003726 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 712938003727 mevalonate kinase; Region: mevalon_kin; TIGR00549 712938003728 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 712938003729 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 712938003730 active site 712938003731 catalytic triad [active] 712938003732 oxyanion hole [active] 712938003733 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 712938003734 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 712938003735 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 712938003736 Walker A/P-loop; other site 712938003737 ATP binding site [chemical binding]; other site 712938003738 Q-loop/lid; other site 712938003739 ABC transporter signature motif; other site 712938003740 Walker B; other site 712938003741 D-loop; other site 712938003742 H-loop/switch region; other site 712938003743 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 712938003744 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 712938003745 substrate binding pocket [chemical binding]; other site 712938003746 membrane-bound complex binding site; other site 712938003747 hinge residues; other site 712938003748 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 712938003749 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 712938003750 NAD binding site [chemical binding]; other site 712938003751 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 712938003752 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 712938003753 active site 712938003754 Zn binding site [ion binding]; other site 712938003755 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 712938003756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 712938003757 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 712938003758 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 712938003759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 712938003760 Walker A motif; other site 712938003761 ATP binding site [chemical binding]; other site 712938003762 Walker B motif; other site 712938003763 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 712938003764 active site 712938003765 DNA binding site [nucleotide binding] 712938003766 Protein of unknown function, DUF488; Region: DUF488; cl01246 712938003767 Transcriptional regulators [Transcription]; Region: PurR; COG1609 712938003768 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 712938003769 DNA binding site [nucleotide binding] 712938003770 domain linker motif; other site 712938003771 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 712938003772 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 712938003773 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 712938003774 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 712938003775 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 712938003776 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 712938003777 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 712938003778 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 712938003779 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 712938003780 Transposase; Region: DDE_Tnp_ISL3; pfam01610 712938003781 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 712938003782 FtsX-like permease family; Region: FtsX; pfam02687 712938003783 manganese transport protein MntH; Reviewed; Region: PRK00701 712938003784 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 712938003785 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 712938003786 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 712938003787 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 712938003788 active site 712938003789 dimer interface [polypeptide binding]; other site 712938003790 motif 1; other site 712938003791 motif 2; other site 712938003792 motif 3; other site 712938003793 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 712938003794 anticodon binding site; other site 712938003795 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 712938003796 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 712938003797 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 712938003798 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 712938003799 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 712938003800 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 712938003801 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 712938003802 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 712938003803 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 712938003804 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 712938003805 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 712938003806 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 712938003807 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 712938003808 active site 712938003809 dimer interface [polypeptide binding]; other site 712938003810 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 712938003811 Ligand Binding Site [chemical binding]; other site 712938003812 Molecular Tunnel; other site 712938003813 lysine transporter; Provisional; Region: PRK10836 712938003814 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 712938003815 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 712938003816 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 712938003817 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 712938003818 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 712938003819 trmE is a tRNA modification GTPase; Region: trmE; cd04164 712938003820 G1 box; other site 712938003821 GTP/Mg2+ binding site [chemical binding]; other site 712938003822 Switch I region; other site 712938003823 G2 box; other site 712938003824 Switch II region; other site 712938003825 G3 box; other site 712938003826 G4 box; other site 712938003827 G5 box; other site 712938003828 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 712938003829 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 712938003830 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 712938003831 G-X-X-G motif; other site 712938003832 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 712938003833 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 712938003834 ribonuclease P; Reviewed; Region: rnpA; PRK00499