-- dump date 20140619_123403 -- class Genbank::misc_feature -- table misc_feature_note -- id note 767453000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 767453000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 767453000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767453000004 Walker A motif; other site 767453000005 ATP binding site [chemical binding]; other site 767453000006 Walker B motif; other site 767453000007 arginine finger; other site 767453000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 767453000009 DnaA box-binding interface [nucleotide binding]; other site 767453000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 767453000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 767453000012 putative DNA binding surface [nucleotide binding]; other site 767453000013 dimer interface [polypeptide binding]; other site 767453000014 beta-clamp/clamp loader binding surface; other site 767453000015 beta-clamp/translesion DNA polymerase binding surface; other site 767453000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 767453000017 recombination protein F; Reviewed; Region: recF; PRK00064 767453000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 767453000019 Walker A/P-loop; other site 767453000020 ATP binding site [chemical binding]; other site 767453000021 Q-loop/lid; other site 767453000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767453000023 ABC transporter signature motif; other site 767453000024 Walker B; other site 767453000025 D-loop; other site 767453000026 H-loop/switch region; other site 767453000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 767453000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767453000029 ATP binding site [chemical binding]; other site 767453000030 Mg2+ binding site [ion binding]; other site 767453000031 G-X-G motif; other site 767453000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 767453000033 anchoring element; other site 767453000034 dimer interface [polypeptide binding]; other site 767453000035 ATP binding site [chemical binding]; other site 767453000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 767453000037 active site 767453000038 putative metal-binding site [ion binding]; other site 767453000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 767453000040 DNA gyrase subunit A; Validated; Region: PRK05560 767453000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 767453000042 CAP-like domain; other site 767453000043 active site 767453000044 primary dimer interface [polypeptide binding]; other site 767453000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767453000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767453000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767453000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767453000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767453000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767453000051 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 767453000052 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 767453000053 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 767453000054 dimer interface [polypeptide binding]; other site 767453000055 ssDNA binding site [nucleotide binding]; other site 767453000056 tetramer (dimer of dimers) interface [polypeptide binding]; other site 767453000057 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 767453000058 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 767453000059 DHH family; Region: DHH; pfam01368 767453000060 DHHA1 domain; Region: DHHA1; pfam02272 767453000061 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 767453000062 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 767453000063 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 767453000064 replicative DNA helicase; Region: DnaB; TIGR00665 767453000065 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 767453000066 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 767453000067 Walker A motif; other site 767453000068 ATP binding site [chemical binding]; other site 767453000069 Walker B motif; other site 767453000070 DNA binding loops [nucleotide binding] 767453000071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453000072 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767453000073 putative substrate translocation pore; other site 767453000074 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767453000075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767453000076 active site 767453000077 phosphorylation site [posttranslational modification] 767453000078 intermolecular recognition site; other site 767453000079 dimerization interface [polypeptide binding]; other site 767453000080 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767453000081 DNA binding site [nucleotide binding] 767453000082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 767453000083 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767453000084 dimerization interface [polypeptide binding]; other site 767453000085 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 767453000086 putative active site [active] 767453000087 heme pocket [chemical binding]; other site 767453000088 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767453000089 dimer interface [polypeptide binding]; other site 767453000090 phosphorylation site [posttranslational modification] 767453000091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767453000092 ATP binding site [chemical binding]; other site 767453000093 Mg2+ binding site [ion binding]; other site 767453000094 G-X-G motif; other site 767453000095 YycH protein; Region: YycH; pfam07435 767453000096 YycH protein; Region: YycI; pfam09648 767453000097 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 767453000098 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 767453000099 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 767453000100 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 767453000101 Predicted transcriptional regulator [Transcription]; Region: COG1959 767453000102 Transcriptional regulator; Region: Rrf2; pfam02082 767453000103 Transcriptional regulators [Transcription]; Region: PurR; COG1609 767453000104 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767453000105 DNA binding site [nucleotide binding] 767453000106 domain linker motif; other site 767453000107 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 767453000108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453000109 putative substrate translocation pore; other site 767453000110 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767453000111 maltose phosphorylase; Provisional; Region: PRK13807 767453000112 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 767453000113 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 767453000114 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 767453000115 beta-phosphoglucomutase; Region: bPGM; TIGR01990 767453000116 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767453000117 motif II; other site 767453000118 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 767453000119 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 767453000120 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 767453000121 active site 767453000122 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 767453000123 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 767453000124 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 767453000125 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 767453000126 homodimer interface [polypeptide binding]; other site 767453000127 ligand binding site [chemical binding]; other site 767453000128 NAD binding site [chemical binding]; other site 767453000129 catalytic site [active] 767453000130 aromatic amino acid aminotransferase; Validated; Region: PRK07309 767453000131 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767453000132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767453000133 homodimer interface [polypeptide binding]; other site 767453000134 catalytic residue [active] 767453000135 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767453000136 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 767453000137 Walker A motif; other site 767453000138 ATP binding site [chemical binding]; other site 767453000139 Walker B motif; other site 767453000140 arginine finger; other site 767453000141 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767453000142 Walker A motif; other site 767453000143 ATP binding site [chemical binding]; other site 767453000144 Walker B motif; other site 767453000145 arginine finger; other site 767453000146 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 767453000147 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 767453000148 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 767453000149 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 767453000150 putative active site [active] 767453000151 catalytic site [active] 767453000152 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 767453000153 putative active site [active] 767453000154 catalytic site [active] 767453000155 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 767453000156 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767453000157 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 767453000158 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 767453000159 Part of AAA domain; Region: AAA_19; pfam13245 767453000160 Family description; Region: UvrD_C_2; pfam13538 767453000161 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 767453000162 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 767453000163 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 767453000164 active site 767453000165 catalytic tetrad [active] 767453000166 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 767453000167 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 767453000168 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 767453000169 putative active site [active] 767453000170 catalytic site [active] 767453000171 putative metal binding site [ion binding]; other site 767453000172 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 767453000173 ArsC family; Region: ArsC; pfam03960 767453000174 putative ArsC-like catalytic residues; other site 767453000175 putative TRX-like catalytic residues [active] 767453000176 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 767453000177 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 767453000178 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 767453000179 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767453000180 Walker A/P-loop; other site 767453000181 ATP binding site [chemical binding]; other site 767453000182 Q-loop/lid; other site 767453000183 ABC transporter signature motif; other site 767453000184 Walker B; other site 767453000185 D-loop; other site 767453000186 H-loop/switch region; other site 767453000187 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767453000188 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767453000189 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 767453000190 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 767453000191 active site 767453000192 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 767453000193 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 767453000194 IMP binding site; other site 767453000195 GDP-binding site [chemical binding]; other site 767453000196 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 767453000197 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 767453000198 NAD(P) binding site [chemical binding]; other site 767453000199 catalytic residues [active] 767453000200 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 767453000201 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767453000202 active site 767453000203 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 767453000204 active site 767453000205 dimer interface [polypeptide binding]; other site 767453000206 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767453000207 active site 767453000208 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 767453000209 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 767453000210 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 767453000211 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767453000212 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 767453000213 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 767453000214 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767453000215 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 767453000216 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 767453000217 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 767453000218 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 767453000219 Walker A/P-loop; other site 767453000220 ATP binding site [chemical binding]; other site 767453000221 Q-loop/lid; other site 767453000222 ABC transporter signature motif; other site 767453000223 Walker B; other site 767453000224 D-loop; other site 767453000225 H-loop/switch region; other site 767453000226 NIL domain; Region: NIL; pfam09383 767453000227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767453000228 ABC-ATPase subunit interface; other site 767453000229 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 767453000230 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 767453000231 metal binding site [ion binding]; metal-binding site 767453000232 dimer interface [polypeptide binding]; other site 767453000233 TRAM domain; Region: TRAM; pfam01938 767453000234 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 767453000235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767453000236 S-adenosylmethionine binding site [chemical binding]; other site 767453000237 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 767453000238 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 767453000239 active site 767453000240 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 767453000241 DltD N-terminal region; Region: DltD_N; pfam04915 767453000242 DltD central region; Region: DltD_M; pfam04918 767453000243 DltD C-terminal region; Region: DltD_C; pfam04914 767453000244 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 767453000245 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 767453000246 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 767453000247 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 767453000248 acyl-activating enzyme (AAE) consensus motif; other site 767453000249 AMP binding site [chemical binding]; other site 767453000250 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 767453000251 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 767453000252 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767453000253 active site 767453000254 metal binding site [ion binding]; metal-binding site 767453000255 DNA binding site [nucleotide binding] 767453000256 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 767453000257 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 767453000258 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 767453000259 Walker A/P-loop; other site 767453000260 ATP binding site [chemical binding]; other site 767453000261 Q-loop/lid; other site 767453000262 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767453000263 ABC transporter signature motif; other site 767453000264 Walker B; other site 767453000265 D-loop; other site 767453000266 H-loop/switch region; other site 767453000267 seryl-tRNA synthetase; Provisional; Region: PRK05431 767453000268 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 767453000269 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 767453000270 dimer interface [polypeptide binding]; other site 767453000271 active site 767453000272 motif 1; other site 767453000273 motif 2; other site 767453000274 motif 3; other site 767453000275 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453000276 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453000277 Probable transposase; Region: OrfB_IS605; pfam01385 767453000278 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453000279 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453000280 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 767453000281 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 767453000282 active site 767453000283 HIGH motif; other site 767453000284 dimer interface [polypeptide binding]; other site 767453000285 KMSKS motif; other site 767453000286 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 767453000287 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 767453000288 active site 767453000289 HIGH motif; other site 767453000290 dimer interface [polypeptide binding]; other site 767453000291 KMSKS motif; other site 767453000292 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767453000293 RNA binding surface [nucleotide binding]; other site 767453000294 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767453000295 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767453000296 substrate binding pocket [chemical binding]; other site 767453000297 membrane-bound complex binding site; other site 767453000298 hinge residues; other site 767453000299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767453000300 dimer interface [polypeptide binding]; other site 767453000301 conserved gate region; other site 767453000302 putative PBP binding loops; other site 767453000303 ABC-ATPase subunit interface; other site 767453000304 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 767453000305 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 767453000306 Walker A/P-loop; other site 767453000307 ATP binding site [chemical binding]; other site 767453000308 Q-loop/lid; other site 767453000309 ABC transporter signature motif; other site 767453000310 Walker B; other site 767453000311 D-loop; other site 767453000312 H-loop/switch region; other site 767453000313 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 767453000314 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 767453000315 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 767453000316 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 767453000317 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 767453000318 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 767453000319 active site 767453000320 tetramer interface [polypeptide binding]; other site 767453000321 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 767453000322 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 767453000323 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 767453000324 ParB-like nuclease domain; Region: ParBc; pfam02195 767453000325 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 767453000326 ParB-like nuclease domain; Region: ParBc; pfam02195 767453000327 KorB domain; Region: KorB; pfam08535 767453000328 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 767453000329 GTP-binding protein YchF; Reviewed; Region: PRK09601 767453000330 YchF GTPase; Region: YchF; cd01900 767453000331 G1 box; other site 767453000332 GTP/Mg2+ binding site [chemical binding]; other site 767453000333 Switch I region; other site 767453000334 G2 box; other site 767453000335 Switch II region; other site 767453000336 G3 box; other site 767453000337 G4 box; other site 767453000338 G5 box; other site 767453000339 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 767453000340 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 767453000341 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 767453000342 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 767453000343 active site 767453000344 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 767453000345 Chain length determinant protein; Region: Wzz; cl15801 767453000346 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 767453000347 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 767453000348 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 767453000349 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 767453000350 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 767453000351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767453000352 NAD(P) binding site [chemical binding]; other site 767453000353 active site 767453000354 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 767453000355 Bacterial sugar transferase; Region: Bac_transf; pfam02397 767453000356 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 767453000357 active site 767453000358 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 767453000359 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 767453000360 active site 767453000361 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767453000362 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 767453000363 putative ADP-binding pocket [chemical binding]; other site 767453000364 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 767453000365 active site 767453000366 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 767453000367 active site 767453000368 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 767453000369 Helix-turn-helix domain; Region: HTH_38; pfam13936 767453000370 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453000371 Integrase core domain; Region: rve; pfam00665 767453000372 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 767453000373 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 767453000374 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453000375 Helix-turn-helix domain; Region: HTH_38; pfam13936 767453000376 Integrase core domain; Region: rve; pfam00665 767453000377 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767453000378 Helix-turn-helix domain; Region: HTH_28; pfam13518 767453000379 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 767453000380 MULE transposase domain; Region: MULE; pfam10551 767453000381 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767453000382 MULE transposase domain; Region: MULE; pfam10551 767453000383 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 767453000384 HTH-like domain; Region: HTH_21; pfam13276 767453000385 Integrase core domain; Region: rve; pfam00665 767453000386 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767453000387 Helix-turn-helix domain; Region: HTH_28; pfam13518 767453000388 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 767453000389 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767453000390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767453000391 active site 767453000392 phosphorylation site [posttranslational modification] 767453000393 intermolecular recognition site; other site 767453000394 dimerization interface [polypeptide binding]; other site 767453000395 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767453000396 DNA binding site [nucleotide binding] 767453000397 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767453000398 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767453000399 dimer interface [polypeptide binding]; other site 767453000400 phosphorylation site [posttranslational modification] 767453000401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767453000402 ATP binding site [chemical binding]; other site 767453000403 Mg2+ binding site [ion binding]; other site 767453000404 G-X-G motif; other site 767453000405 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 767453000406 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 767453000407 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 767453000408 AzlC protein; Region: AzlC; pfam03591 767453000409 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 767453000410 Serine hydrolase; Region: Ser_hydrolase; cl17834 767453000411 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767453000412 MULE transposase domain; Region: MULE; pfam10551 767453000413 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 767453000414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767453000415 S-adenosylmethionine binding site [chemical binding]; other site 767453000416 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453000417 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453000418 Probable transposase; Region: OrfB_IS605; pfam01385 767453000419 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453000420 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453000421 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 767453000422 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 767453000423 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 767453000424 Potassium binding sites [ion binding]; other site 767453000425 Cesium cation binding sites [ion binding]; other site 767453000426 AIR carboxylase; Region: AIRC; pfam00731 767453000427 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 767453000428 ATP-grasp domain; Region: ATP-grasp; pfam02222 767453000429 adenylosuccinate lyase; Provisional; Region: PRK07492 767453000430 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 767453000431 tetramer interface [polypeptide binding]; other site 767453000432 active site 767453000433 Double zinc ribbon; Region: DZR; pfam12773 767453000434 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 767453000435 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 767453000436 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 767453000437 Double zinc ribbon; Region: DZR; pfam12773 767453000438 Predicted membrane protein [Function unknown]; Region: COG4640 767453000439 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 767453000440 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 767453000441 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 767453000442 ATP binding site [chemical binding]; other site 767453000443 active site 767453000444 substrate binding site [chemical binding]; other site 767453000445 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 767453000446 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 767453000447 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 767453000448 putative active site [active] 767453000449 catalytic triad [active] 767453000450 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 767453000451 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 767453000452 dimerization interface [polypeptide binding]; other site 767453000453 ATP binding site [chemical binding]; other site 767453000454 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 767453000455 dimerization interface [polypeptide binding]; other site 767453000456 ATP binding site [chemical binding]; other site 767453000457 amidophosphoribosyltransferase; Provisional; Region: PRK07272 767453000458 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 767453000459 active site 767453000460 tetramer interface [polypeptide binding]; other site 767453000461 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767453000462 active site 767453000463 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 767453000464 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 767453000465 dimerization interface [polypeptide binding]; other site 767453000466 putative ATP binding site [chemical binding]; other site 767453000467 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 767453000468 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 767453000469 active site 767453000470 substrate binding site [chemical binding]; other site 767453000471 cosubstrate binding site; other site 767453000472 catalytic site [active] 767453000473 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 767453000474 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 767453000475 purine monophosphate binding site [chemical binding]; other site 767453000476 dimer interface [polypeptide binding]; other site 767453000477 putative catalytic residues [active] 767453000478 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 767453000479 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 767453000480 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453000481 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453000482 Probable transposase; Region: OrfB_IS605; pfam01385 767453000483 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453000484 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453000485 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 767453000486 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 767453000487 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 767453000488 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 767453000489 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453000490 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453000491 Probable transposase; Region: OrfB_IS605; pfam01385 767453000492 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453000493 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453000494 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767453000495 MULE transposase domain; Region: MULE; pfam10551 767453000496 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767453000497 catalytic core [active] 767453000498 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767453000499 aromatic amino acid aminotransferase; Validated; Region: PRK07309 767453000500 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767453000501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767453000502 homodimer interface [polypeptide binding]; other site 767453000503 catalytic residue [active] 767453000504 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 767453000505 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 767453000506 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 767453000507 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767453000508 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 767453000509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453000510 putative substrate translocation pore; other site 767453000511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453000512 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 767453000513 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 767453000514 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 767453000515 putative FMN binding site [chemical binding]; other site 767453000516 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 767453000517 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 767453000518 classical (c) SDRs; Region: SDR_c; cd05233 767453000519 NAD(P) binding site [chemical binding]; other site 767453000520 active site 767453000521 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 767453000522 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 767453000523 active site 767453000524 catalytic tetrad [active] 767453000525 CsbD-like; Region: CsbD; pfam05532 767453000526 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 767453000527 catalytic tetrad [active] 767453000528 Cadmium resistance transporter; Region: Cad; pfam03596 767453000529 EamA-like transporter family; Region: EamA; pfam00892 767453000530 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 767453000531 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 767453000532 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 767453000533 heme-binding site [chemical binding]; other site 767453000534 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 767453000535 heme-binding site [chemical binding]; other site 767453000536 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 767453000537 heme-binding site [chemical binding]; other site 767453000538 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 767453000539 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 767453000540 intersubunit interface [polypeptide binding]; other site 767453000541 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 767453000542 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 767453000543 ABC-ATPase subunit interface; other site 767453000544 dimer interface [polypeptide binding]; other site 767453000545 putative PBP binding regions; other site 767453000546 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 767453000547 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 767453000548 Walker A/P-loop; other site 767453000549 ATP binding site [chemical binding]; other site 767453000550 Q-loop/lid; other site 767453000551 ABC transporter signature motif; other site 767453000552 Walker B; other site 767453000553 D-loop; other site 767453000554 H-loop/switch region; other site 767453000555 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 767453000556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453000557 putative substrate translocation pore; other site 767453000558 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 767453000559 active site 767453000560 putative catalytic site [active] 767453000561 DNA binding site [nucleotide binding] 767453000562 putative phosphate binding site [ion binding]; other site 767453000563 metal binding site A [ion binding]; metal-binding site 767453000564 AP binding site [nucleotide binding]; other site 767453000565 metal binding site B [ion binding]; metal-binding site 767453000566 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 767453000567 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 767453000568 putative ligand binding site [chemical binding]; other site 767453000569 putative NAD binding site [chemical binding]; other site 767453000570 catalytic site [active] 767453000571 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 767453000572 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 767453000573 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767453000574 catalytic residue [active] 767453000575 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 767453000576 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 767453000577 homodimer interface [polypeptide binding]; other site 767453000578 nucleotide binding site [chemical binding]; other site 767453000579 nucleotide binding site [chemical binding]; other site 767453000580 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 767453000581 putative FMN binding site [chemical binding]; other site 767453000582 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 767453000583 active site 767453000584 catalytic triad [active] 767453000585 oxyanion hole [active] 767453000586 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453000587 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453000588 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453000589 Probable transposase; Region: OrfB_IS605; pfam01385 767453000590 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453000591 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u3; cd11540 767453000592 putative metal binding site [ion binding]; other site 767453000593 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 767453000594 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 767453000595 catalytic Zn binding site [ion binding]; other site 767453000596 NAD(P) binding site [chemical binding]; other site 767453000597 structural Zn binding site [ion binding]; other site 767453000598 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 767453000599 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 767453000600 Zn binding site [ion binding]; other site 767453000601 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 767453000602 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 767453000603 Serine hydrolase; Region: Ser_hydrolase; cl17834 767453000604 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 767453000605 dimer interface [polypeptide binding]; other site 767453000606 FMN binding site [chemical binding]; other site 767453000607 NADPH bind site [chemical binding]; other site 767453000608 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453000609 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453000610 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453000611 Probable transposase; Region: OrfB_IS605; pfam01385 767453000612 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453000613 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 767453000614 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 767453000615 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 767453000616 Part of AAA domain; Region: AAA_19; pfam13245 767453000617 Family description; Region: UvrD_C_2; pfam13538 767453000618 exopolyphosphatase; Region: exo_poly_only; TIGR03706 767453000619 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 767453000620 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 767453000621 homodimer interface [polypeptide binding]; other site 767453000622 catalytic residues [active] 767453000623 NAD binding site [chemical binding]; other site 767453000624 substrate binding pocket [chemical binding]; other site 767453000625 flexible flap; other site 767453000626 NAD-dependent deacetylase; Provisional; Region: PRK00481 767453000627 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 767453000628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453000629 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767453000630 putative substrate translocation pore; other site 767453000631 Protein of unknown function DUF72; Region: DUF72; pfam01904 767453000632 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 767453000633 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 767453000634 HIGH motif; other site 767453000635 active site 767453000636 KMSKS motif; other site 767453000637 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 767453000638 tRNA binding surface [nucleotide binding]; other site 767453000639 anticodon binding site; other site 767453000640 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 767453000641 dimer interface [polypeptide binding]; other site 767453000642 putative tRNA-binding site [nucleotide binding]; other site 767453000643 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 767453000644 active site 767453000645 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 767453000646 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 767453000647 putative active site [active] 767453000648 putative metal binding site [ion binding]; other site 767453000649 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 767453000650 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 767453000651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767453000652 S-adenosylmethionine binding site [chemical binding]; other site 767453000653 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 767453000654 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 767453000655 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 767453000656 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 767453000657 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 767453000658 metal binding site [ion binding]; metal-binding site 767453000659 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767453000660 Walker A/P-loop; other site 767453000661 ATP binding site [chemical binding]; other site 767453000662 Q-loop/lid; other site 767453000663 ABC transporter signature motif; other site 767453000664 Walker B; other site 767453000665 D-loop; other site 767453000666 H-loop/switch region; other site 767453000667 pur operon repressor; Provisional; Region: PRK09213 767453000668 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 767453000669 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767453000670 active site 767453000671 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 767453000672 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 767453000673 Substrate binding site; other site 767453000674 Mg++ binding site; other site 767453000675 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 767453000676 active site 767453000677 substrate binding site [chemical binding]; other site 767453000678 CoA binding site [chemical binding]; other site 767453000679 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 767453000680 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 767453000681 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767453000682 active site 767453000683 sugar phosphate phosphatase; Provisional; Region: PRK10513 767453000684 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767453000685 active site 767453000686 motif I; other site 767453000687 motif II; other site 767453000688 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 767453000689 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767453000690 Zn2+ binding site [ion binding]; other site 767453000691 Mg2+ binding site [ion binding]; other site 767453000692 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 767453000693 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 767453000694 CTP synthetase; Validated; Region: pyrG; PRK05380 767453000695 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 767453000696 Catalytic site [active] 767453000697 active site 767453000698 UTP binding site [chemical binding]; other site 767453000699 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 767453000700 active site 767453000701 putative oxyanion hole; other site 767453000702 catalytic triad [active] 767453000703 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 767453000704 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 767453000705 hinge; other site 767453000706 active site 767453000707 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 767453000708 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453000709 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453000710 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453000711 Probable transposase; Region: OrfB_IS605; pfam01385 767453000712 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453000713 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 767453000714 active site 767453000715 catalytic site [active] 767453000716 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 767453000717 Low molecular weight phosphatase family; Region: LMWPc; cd00115 767453000718 active site 767453000719 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 767453000720 heat shock protein HtpX; Provisional; Region: PRK04897 767453000721 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 767453000722 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 767453000723 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767453000724 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767453000725 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 767453000726 DEAD-like helicases superfamily; Region: DEXDc; smart00487 767453000727 ATP binding site [chemical binding]; other site 767453000728 Mg++ binding site [ion binding]; other site 767453000729 motif III; other site 767453000730 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767453000731 nucleotide binding region [chemical binding]; other site 767453000732 ATP-binding site [chemical binding]; other site 767453000733 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 767453000734 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 767453000735 alanine racemase; Reviewed; Region: alr; PRK00053 767453000736 active site 767453000737 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 767453000738 dimer interface [polypeptide binding]; other site 767453000739 substrate binding site [chemical binding]; other site 767453000740 catalytic residues [active] 767453000741 PemK-like protein; Region: PemK; pfam02452 767453000742 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 767453000743 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 767453000744 putative active site [active] 767453000745 catalytic residue [active] 767453000746 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 767453000747 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 767453000748 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767453000749 ATP binding site [chemical binding]; other site 767453000750 putative Mg++ binding site [ion binding]; other site 767453000751 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767453000752 nucleotide binding region [chemical binding]; other site 767453000753 ATP-binding site [chemical binding]; other site 767453000754 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 767453000755 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767453000756 RNA binding surface [nucleotide binding]; other site 767453000757 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 767453000758 Septum formation initiator; Region: DivIC; pfam04977 767453000759 hypothetical protein; Provisional; Region: PRK08582 767453000760 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 767453000761 RNA binding site [nucleotide binding]; other site 767453000762 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 767453000763 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 767453000764 TilS substrate C-terminal domain; Region: TilS_C; smart00977 767453000765 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767453000766 active site 767453000767 FtsH Extracellular; Region: FtsH_ext; pfam06480 767453000768 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 767453000769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767453000770 Walker A motif; other site 767453000771 ATP binding site [chemical binding]; other site 767453000772 Walker B motif; other site 767453000773 arginine finger; other site 767453000774 Peptidase family M41; Region: Peptidase_M41; pfam01434 767453000775 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 767453000776 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 767453000777 dimerization interface [polypeptide binding]; other site 767453000778 domain crossover interface; other site 767453000779 redox-dependent activation switch; other site 767453000780 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 767453000781 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 767453000782 FMN binding site [chemical binding]; other site 767453000783 active site 767453000784 catalytic residues [active] 767453000785 substrate binding site [chemical binding]; other site 767453000786 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 767453000787 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 767453000788 dimer interface [polypeptide binding]; other site 767453000789 putative anticodon binding site; other site 767453000790 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 767453000791 motif 1; other site 767453000792 active site 767453000793 motif 2; other site 767453000794 motif 3; other site 767453000795 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453000796 Integrase core domain; Region: rve; pfam00665 767453000797 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453000798 Helix-turn-helix domain; Region: HTH_38; pfam13936 767453000799 Integrase core domain; Region: rve; pfam00665 767453000800 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 767453000801 Peptidase family M48; Region: Peptidase_M48; cl12018 767453000802 Double zinc ribbon; Region: DZR; pfam12773 767453000803 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 767453000804 Protein of unknown function (DUF805); Region: DUF805; pfam05656 767453000805 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767453000806 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453000807 Integrase core domain; Region: rve; pfam00665 767453000808 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 767453000809 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 767453000810 POT family; Region: PTR2; cl17359 767453000811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453000812 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 767453000813 putative phosphoesterase; Region: acc_ester; TIGR03729 767453000814 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 767453000815 aspartate racemase; Region: asp_race; TIGR00035 767453000816 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 767453000817 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767453000818 DNA-binding site [nucleotide binding]; DNA binding site 767453000819 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 767453000820 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 767453000821 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 767453000822 active site 767453000823 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 767453000824 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 767453000825 homodimer interface [polypeptide binding]; other site 767453000826 NAD binding pocket [chemical binding]; other site 767453000827 ATP binding pocket [chemical binding]; other site 767453000828 Mg binding site [ion binding]; other site 767453000829 active-site loop [active] 767453000830 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 767453000831 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 767453000832 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 767453000833 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 767453000834 RNA binding site [nucleotide binding]; other site 767453000835 hypothetical protein; Provisional; Region: PRK04351 767453000836 SprT homologues; Region: SprT; cl01182 767453000837 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453000838 Helix-turn-helix domain; Region: HTH_38; pfam13936 767453000839 Homeodomain-like domain; Region: HTH_32; pfam13565 767453000840 Integrase core domain; Region: rve; pfam00665 767453000841 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 767453000842 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 767453000843 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 767453000844 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 767453000845 Predicted permeases [General function prediction only]; Region: COG0679 767453000846 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767453000847 catalytic core [active] 767453000848 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767453000849 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 767453000850 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 767453000851 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 767453000852 trimer interface [polypeptide binding]; other site 767453000853 active site 767453000854 G bulge; other site 767453000855 maltose O-acetyltransferase; Provisional; Region: PRK10092 767453000856 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 767453000857 active site 767453000858 substrate binding site [chemical binding]; other site 767453000859 trimer interface [polypeptide binding]; other site 767453000860 CoA binding site [chemical binding]; other site 767453000861 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 767453000862 tetramer (dimer of dimers) interface [polypeptide binding]; other site 767453000863 active site 767453000864 dimer interface [polypeptide binding]; other site 767453000865 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767453000866 Coenzyme A binding pocket [chemical binding]; other site 767453000867 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 767453000868 trimer interface [polypeptide binding]; other site 767453000869 active site 767453000870 DNA repair protein RadA; Provisional; Region: PRK11823 767453000871 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 767453000872 Walker A motif/ATP binding site; other site 767453000873 ATP binding site [chemical binding]; other site 767453000874 Walker B motif; other site 767453000875 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 767453000876 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 767453000877 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 767453000878 putative active site [active] 767453000879 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 767453000880 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767453000881 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 767453000882 active site 767453000883 KMSKS motif; other site 767453000884 hypothetical protein; Provisional; Region: PRK13690 767453000885 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 767453000886 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 767453000887 active site 767453000888 HIGH motif; other site 767453000889 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 767453000890 KMSKS motif; other site 767453000891 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 767453000892 tRNA binding surface [nucleotide binding]; other site 767453000893 anticodon binding site; other site 767453000894 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 767453000895 active site 767453000896 metal binding site [ion binding]; metal-binding site 767453000897 dimerization interface [polypeptide binding]; other site 767453000898 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 767453000899 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 767453000900 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 767453000901 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 767453000902 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767453000903 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767453000904 DNA binding residues [nucleotide binding] 767453000905 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 767453000906 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 767453000907 putative homodimer interface [polypeptide binding]; other site 767453000908 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 767453000909 heterodimer interface [polypeptide binding]; other site 767453000910 homodimer interface [polypeptide binding]; other site 767453000911 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 767453000912 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 767453000913 L7/L12 interface [polypeptide binding]; other site 767453000914 23S rRNA interface [nucleotide binding]; other site 767453000915 L25 interface [polypeptide binding]; other site 767453000916 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 767453000917 mRNA/rRNA interface [nucleotide binding]; other site 767453000918 Amino acid permease; Region: AA_permease_2; pfam13520 767453000919 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 767453000920 23S rRNA interface [nucleotide binding]; other site 767453000921 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 767453000922 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 767453000923 peripheral dimer interface [polypeptide binding]; other site 767453000924 core dimer interface [polypeptide binding]; other site 767453000925 L10 interface [polypeptide binding]; other site 767453000926 L11 interface [polypeptide binding]; other site 767453000927 putative EF-Tu interaction site [polypeptide binding]; other site 767453000928 putative EF-G interaction site [polypeptide binding]; other site 767453000929 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 767453000930 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 767453000931 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 767453000932 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 767453000933 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 767453000934 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767453000935 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 767453000936 Walker A/P-loop; other site 767453000937 ATP binding site [chemical binding]; other site 767453000938 Q-loop/lid; other site 767453000939 ABC transporter signature motif; other site 767453000940 Walker B; other site 767453000941 D-loop; other site 767453000942 H-loop/switch region; other site 767453000943 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 767453000944 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767453000945 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 767453000946 Walker A/P-loop; other site 767453000947 ATP binding site [chemical binding]; other site 767453000948 Q-loop/lid; other site 767453000949 ABC transporter signature motif; other site 767453000950 Walker B; other site 767453000951 D-loop; other site 767453000952 H-loop/switch region; other site 767453000953 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 767453000954 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 767453000955 putative catalytic cysteine [active] 767453000956 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 767453000957 putative active site [active] 767453000958 metal binding site [ion binding]; metal-binding site 767453000959 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 767453000960 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 767453000961 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 767453000962 dimer interface [polypeptide binding]; other site 767453000963 putative radical transfer pathway; other site 767453000964 diiron center [ion binding]; other site 767453000965 tyrosyl radical; other site 767453000966 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 767453000967 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 767453000968 Class I ribonucleotide reductase; Region: RNR_I; cd01679 767453000969 active site 767453000970 dimer interface [polypeptide binding]; other site 767453000971 catalytic residues [active] 767453000972 effector binding site; other site 767453000973 R2 peptide binding site; other site 767453000974 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 767453000975 catalytic residues [active] 767453000976 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 767453000977 nucleoside/Zn binding site; other site 767453000978 dimer interface [polypeptide binding]; other site 767453000979 catalytic motif [active] 767453000980 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 767453000981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767453000982 Walker A motif; other site 767453000983 ATP binding site [chemical binding]; other site 767453000984 Walker B motif; other site 767453000985 arginine finger; other site 767453000986 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 767453000987 hypothetical protein; Validated; Region: PRK00153 767453000988 recombination protein RecR; Reviewed; Region: recR; PRK00076 767453000989 RecR protein; Region: RecR; pfam02132 767453000990 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 767453000991 putative active site [active] 767453000992 putative metal-binding site [ion binding]; other site 767453000993 tetramer interface [polypeptide binding]; other site 767453000994 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 767453000995 thymidylate kinase; Validated; Region: tmk; PRK00698 767453000996 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 767453000997 TMP-binding site; other site 767453000998 ATP-binding site [chemical binding]; other site 767453000999 Protein of unknown function (DUF970); Region: DUF970; pfam06153 767453001000 Nitrogen regulatory protein P-II; Region: P-II; smart00938 767453001001 DNA polymerase III subunit delta'; Validated; Region: PRK08058 767453001002 DNA polymerase III subunit delta'; Validated; Region: PRK08485 767453001003 Protein of unknown function (DUF972); Region: DUF972; pfam06156 767453001004 Predicted methyltransferases [General function prediction only]; Region: COG0313 767453001005 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 767453001006 putative SAM binding site [chemical binding]; other site 767453001007 putative homodimer interface [polypeptide binding]; other site 767453001008 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 767453001009 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 767453001010 active site 767453001011 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 767453001012 active site 767453001013 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 767453001014 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 767453001015 polyphosphate kinase; Provisional; Region: PRK05443 767453001016 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 767453001017 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 767453001018 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 767453001019 putative domain interface [polypeptide binding]; other site 767453001020 putative active site [active] 767453001021 catalytic site [active] 767453001022 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 767453001023 putative domain interface [polypeptide binding]; other site 767453001024 putative active site [active] 767453001025 catalytic site [active] 767453001026 exopolyphosphatase; Region: exo_poly_only; TIGR03706 767453001027 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 767453001028 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 767453001029 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 767453001030 NAD binding site [chemical binding]; other site 767453001031 homodimer interface [polypeptide binding]; other site 767453001032 active site 767453001033 substrate binding site [chemical binding]; other site 767453001034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767453001035 Response regulator receiver domain; Region: Response_reg; pfam00072 767453001036 active site 767453001037 phosphorylation site [posttranslational modification] 767453001038 intermolecular recognition site; other site 767453001039 dimerization interface [polypeptide binding]; other site 767453001040 YcbB domain; Region: YcbB; pfam08664 767453001041 ornithine carbamoyltransferase; Provisional; Region: PRK04284 767453001042 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 767453001043 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 767453001044 carbamate kinase; Reviewed; Region: PRK12686 767453001045 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 767453001046 putative substrate binding site [chemical binding]; other site 767453001047 nucleotide binding site [chemical binding]; other site 767453001048 nucleotide binding site [chemical binding]; other site 767453001049 homodimer interface [polypeptide binding]; other site 767453001050 arginine deiminase; Provisional; Region: PRK01388 767453001051 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 767453001052 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 767453001053 substrate binding site [chemical binding]; other site 767453001054 THF binding site; other site 767453001055 zinc-binding site [ion binding]; other site 767453001056 transaminase; Validated; Region: PRK07324 767453001057 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767453001058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767453001059 homodimer interface [polypeptide binding]; other site 767453001060 catalytic residue [active] 767453001061 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 767453001062 Glycoprotease family; Region: Peptidase_M22; pfam00814 767453001063 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 767453001064 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767453001065 Coenzyme A binding pocket [chemical binding]; other site 767453001066 UGMP family protein; Validated; Region: PRK09604 767453001067 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 767453001068 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 767453001069 MarR family; Region: MarR_2; pfam12802 767453001070 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767453001071 MarR family; Region: MarR_2; cl17246 767453001072 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 767453001073 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 767453001074 dimer interface [polypeptide binding]; other site 767453001075 active site 767453001076 CoA binding pocket [chemical binding]; other site 767453001077 acyl carrier protein; Provisional; Region: acpP; PRK00982 767453001078 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 767453001079 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 767453001080 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 767453001081 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767453001082 NAD(P) binding site [chemical binding]; other site 767453001083 active site 767453001084 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 767453001085 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 767453001086 dimer interface [polypeptide binding]; other site 767453001087 active site 767453001088 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 767453001089 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 767453001090 carboxyltransferase (CT) interaction site; other site 767453001091 biotinylation site [posttranslational modification]; other site 767453001092 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 767453001093 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 767453001094 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767453001095 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767453001096 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 767453001097 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 767453001098 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 767453001099 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 767453001100 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 767453001101 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 767453001102 NAD binding site [chemical binding]; other site 767453001103 homotetramer interface [polypeptide binding]; other site 767453001104 homodimer interface [polypeptide binding]; other site 767453001105 substrate binding site [chemical binding]; other site 767453001106 active site 767453001107 BioY family; Region: BioY; pfam02632 767453001108 Biotin operon repressor [Transcription]; Region: BirA; COG1654 767453001109 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 767453001110 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 767453001111 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 767453001112 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 767453001113 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 767453001114 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767453001115 Walker A/P-loop; other site 767453001116 ATP binding site [chemical binding]; other site 767453001117 Q-loop/lid; other site 767453001118 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767453001119 ABC transporter signature motif; other site 767453001120 Walker B; other site 767453001121 D-loop; other site 767453001122 H-loop/switch region; other site 767453001123 ABC transporter; Region: ABC_tran_2; pfam12848 767453001124 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767453001125 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 767453001126 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 767453001127 CoA binding domain; Region: CoA_binding; pfam02629 767453001128 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 767453001129 oligomerisation interface [polypeptide binding]; other site 767453001130 mobile loop; other site 767453001131 roof hairpin; other site 767453001132 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 767453001133 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 767453001134 ring oligomerisation interface [polypeptide binding]; other site 767453001135 ATP/Mg binding site [chemical binding]; other site 767453001136 stacking interactions; other site 767453001137 hinge regions; other site 767453001138 Amino acid permease; Region: AA_permease_2; pfam13520 767453001139 Uncharacterized conserved protein [Function unknown]; Region: COG1739 767453001140 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 767453001141 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 767453001142 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 767453001143 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767453001144 ATP binding site [chemical binding]; other site 767453001145 putative Mg++ binding site [ion binding]; other site 767453001146 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767453001147 nucleotide binding region [chemical binding]; other site 767453001148 ATP-binding site [chemical binding]; other site 767453001149 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 767453001150 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767453001151 active site 767453001152 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 767453001153 30S subunit binding site; other site 767453001154 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906 767453001155 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 767453001156 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 767453001157 nucleotide binding region [chemical binding]; other site 767453001158 ATP-binding site [chemical binding]; other site 767453001159 peptide chain release factor 2; Validated; Region: prfB; PRK00578 767453001160 PCRF domain; Region: PCRF; pfam03462 767453001161 RF-1 domain; Region: RF-1; pfam00472 767453001162 PspC domain; Region: PspC; pfam04024 767453001163 Predicted membrane protein [Function unknown]; Region: COG1950 767453001164 HPr kinase/phosphorylase; Provisional; Region: PRK05428 767453001165 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 767453001166 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 767453001167 Hpr binding site; other site 767453001168 active site 767453001169 homohexamer subunit interaction site [polypeptide binding]; other site 767453001170 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 767453001171 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 767453001172 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 767453001173 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 767453001174 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 767453001175 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 767453001176 active site 767453001177 tetramer interface; other site 767453001178 Predicted amidohydrolase [General function prediction only]; Region: COG0388 767453001179 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 767453001180 putative active site [active] 767453001181 catalytic triad [active] 767453001182 putative dimer interface [polypeptide binding]; other site 767453001183 transaminase; Reviewed; Region: PRK08068 767453001184 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767453001185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767453001186 homodimer interface [polypeptide binding]; other site 767453001187 catalytic residue [active] 767453001188 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 767453001189 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 767453001190 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 767453001191 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453001192 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453001193 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453001194 Probable transposase; Region: OrfB_IS605; pfam01385 767453001195 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453001196 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 767453001197 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 767453001198 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767453001199 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767453001200 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 767453001201 conserved cys residue [active] 767453001202 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 767453001203 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 767453001204 dimer interface [polypeptide binding]; other site 767453001205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767453001206 catalytic residue [active] 767453001207 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453001208 Integrase core domain; Region: rve; pfam00665 767453001209 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 767453001210 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 767453001211 homodimer interface [polypeptide binding]; other site 767453001212 substrate-cofactor binding pocket; other site 767453001213 catalytic residue [active] 767453001214 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 767453001215 tetramer (dimer of dimers) interface [polypeptide binding]; other site 767453001216 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 767453001217 NAD binding site [chemical binding]; other site 767453001218 dimer interface [polypeptide binding]; other site 767453001219 substrate binding site [chemical binding]; other site 767453001220 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 767453001221 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 767453001222 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 767453001223 active site 767453001224 substrate binding site [chemical binding]; other site 767453001225 metal binding site [ion binding]; metal-binding site 767453001226 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767453001227 Zn2+ binding site [ion binding]; other site 767453001228 Mg2+ binding site [ion binding]; other site 767453001229 excinuclease ABC subunit B; Provisional; Region: PRK05298 767453001230 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767453001231 ATP binding site [chemical binding]; other site 767453001232 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767453001233 nucleotide binding region [chemical binding]; other site 767453001234 ATP-binding site [chemical binding]; other site 767453001235 Ultra-violet resistance protein B; Region: UvrB; pfam12344 767453001236 UvrB/uvrC motif; Region: UVR; pfam02151 767453001237 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 767453001238 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 767453001239 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 767453001240 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 767453001241 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 767453001242 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 767453001243 active site 767453001244 catalytic site [active] 767453001245 substrate binding site [chemical binding]; other site 767453001246 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 767453001247 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 767453001248 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 767453001249 phosphate binding site [ion binding]; other site 767453001250 putative substrate binding pocket [chemical binding]; other site 767453001251 dimer interface [polypeptide binding]; other site 767453001252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 767453001253 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 767453001254 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 767453001255 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 767453001256 oligomer interface [polypeptide binding]; other site 767453001257 active site residues [active] 767453001258 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 767453001259 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 767453001260 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 767453001261 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 767453001262 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 767453001263 Int/Topo IB signature motif; other site 767453001264 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 767453001265 TIGR02687 family protein; Region: TIGR02687 767453001266 PglZ domain; Region: PglZ; pfam08665 767453001267 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 767453001268 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 767453001269 Protein of unknown function DUF262; Region: DUF262; pfam03235 767453001270 Uncharacterized conserved protein [Function unknown]; Region: COG1479 767453001271 Uncharacterized conserved protein [Function unknown]; Region: COG3472 767453001272 Helix-turn-helix domain; Region: HTH_28; pfam13518 767453001273 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 767453001274 substrate binding site [chemical binding]; other site 767453001275 THF binding site; other site 767453001276 zinc-binding site [ion binding]; other site 767453001277 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 767453001278 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 767453001279 Domain of unknown function DUF21; Region: DUF21; pfam01595 767453001280 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 767453001281 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767453001282 MULE transposase domain; Region: MULE; pfam10551 767453001283 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 767453001284 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 767453001285 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 767453001286 Phosphoglycerate kinase; Region: PGK; pfam00162 767453001287 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 767453001288 substrate binding site [chemical binding]; other site 767453001289 hinge regions; other site 767453001290 ADP binding site [chemical binding]; other site 767453001291 catalytic site [active] 767453001292 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 767453001293 triosephosphate isomerase; Provisional; Region: PRK14565 767453001294 substrate binding site [chemical binding]; other site 767453001295 dimer interface [polypeptide binding]; other site 767453001296 catalytic triad [active] 767453001297 enolase; Provisional; Region: eno; PRK00077 767453001298 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 767453001299 dimer interface [polypeptide binding]; other site 767453001300 metal binding site [ion binding]; metal-binding site 767453001301 substrate binding pocket [chemical binding]; other site 767453001302 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 767453001303 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 767453001304 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 767453001305 Cl- selectivity filter; other site 767453001306 Cl- binding residues [ion binding]; other site 767453001307 pore gating glutamate residue; other site 767453001308 dimer interface [polypeptide binding]; other site 767453001309 H+/Cl- coupling transport residue; other site 767453001310 TrkA-C domain; Region: TrkA_C; pfam02080 767453001311 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 767453001312 ribonuclease R; Region: RNase_R; TIGR02063 767453001313 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 767453001314 RNB domain; Region: RNB; pfam00773 767453001315 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 767453001316 RNA binding site [nucleotide binding]; other site 767453001317 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 767453001318 SmpB-tmRNA interface; other site 767453001319 Tubby C 2; Region: Tub_2; cl02043 767453001320 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 767453001321 ligand binding site [chemical binding]; other site 767453001322 active site 767453001323 UGI interface [polypeptide binding]; other site 767453001324 catalytic site [active] 767453001325 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 767453001326 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 767453001327 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767453001328 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 767453001329 Coenzyme A binding pocket [chemical binding]; other site 767453001330 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 767453001331 active site 767453001332 catalytic site [active] 767453001333 substrate binding site [chemical binding]; other site 767453001334 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 767453001335 FAD binding domain; Region: FAD_binding_4; pfam01565 767453001336 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 767453001337 Uncharacterized conserved protein [Function unknown]; Region: COG1624 767453001338 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 767453001339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 767453001340 YbbR-like protein; Region: YbbR; pfam07949 767453001341 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 767453001342 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 767453001343 active site 767453001344 substrate binding site [chemical binding]; other site 767453001345 metal binding site [ion binding]; metal-binding site 767453001346 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 767453001347 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 767453001348 glutaminase active site [active] 767453001349 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 767453001350 dimer interface [polypeptide binding]; other site 767453001351 active site 767453001352 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 767453001353 dimer interface [polypeptide binding]; other site 767453001354 active site 767453001355 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 767453001356 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 767453001357 catalytic triad [active] 767453001358 catalytic triad [active] 767453001359 oxyanion hole [active] 767453001360 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 767453001361 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767453001362 active site 767453001363 motif I; other site 767453001364 motif II; other site 767453001365 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 767453001366 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767453001367 Predicted membrane protein [Function unknown]; Region: COG2855 767453001368 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767453001369 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767453001370 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 767453001371 dimerization interface [polypeptide binding]; other site 767453001372 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453001373 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453001374 Probable transposase; Region: OrfB_IS605; pfam01385 767453001375 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453001376 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453001377 Helix-turn-helix domain; Region: HTH_38; pfam13936 767453001378 Integrase core domain; Region: rve; pfam00665 767453001379 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453001380 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 767453001381 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 767453001382 EDD domain protein, DegV family; Region: DegV; TIGR00762 767453001383 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 767453001384 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 767453001385 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 767453001386 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 767453001387 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 767453001388 active pocket/dimerization site; other site 767453001389 active site 767453001390 phosphorylation site [posttranslational modification] 767453001391 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 767453001392 active site 767453001393 phosphorylation site [posttranslational modification] 767453001394 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 767453001395 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 767453001396 Domain of unknown function (DUF956); Region: DUF956; cl01917 767453001397 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453001398 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453001399 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453001400 Probable transposase; Region: OrfB_IS605; pfam01385 767453001401 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453001402 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767453001403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767453001404 active site 767453001405 phosphorylation site [posttranslational modification] 767453001406 intermolecular recognition site; other site 767453001407 dimerization interface [polypeptide binding]; other site 767453001408 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767453001409 DNA binding site [nucleotide binding] 767453001410 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767453001411 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 767453001412 dimerization interface [polypeptide binding]; other site 767453001413 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767453001414 dimer interface [polypeptide binding]; other site 767453001415 phosphorylation site [posttranslational modification] 767453001416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767453001417 ATP binding site [chemical binding]; other site 767453001418 Mg2+ binding site [ion binding]; other site 767453001419 G-X-G motif; other site 767453001420 Sugar transport protein; Region: Sugar_transport; pfam06800 767453001421 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767453001422 Helix-turn-helix domain; Region: HTH_28; pfam13518 767453001423 Helix-turn-helix domain; Region: HTH_28; pfam13518 767453001424 HTH-like domain; Region: HTH_21; pfam13276 767453001425 Integrase core domain; Region: rve; pfam00665 767453001426 peroxiredoxin; Region: AhpC; TIGR03137 767453001427 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 767453001428 dimer interface [polypeptide binding]; other site 767453001429 decamer (pentamer of dimers) interface [polypeptide binding]; other site 767453001430 catalytic triad [active] 767453001431 peroxidatic and resolving cysteines [active] 767453001432 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 767453001433 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767453001434 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767453001435 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 767453001436 catalytic residue [active] 767453001437 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 767453001438 catalytic residues [active] 767453001439 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 767453001440 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767453001441 Coenzyme A binding pocket [chemical binding]; other site 767453001442 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 767453001443 active site 767453001444 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 767453001445 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 767453001446 active site 767453001447 catalytic tetrad [active] 767453001448 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 767453001449 dimer interface [polypeptide binding]; other site 767453001450 substrate binding site [chemical binding]; other site 767453001451 catalytic triad [active] 767453001452 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 767453001453 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767453001454 MarR family; Region: MarR_2; cl17246 767453001455 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767453001456 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767453001457 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767453001458 Walker A/P-loop; other site 767453001459 ATP binding site [chemical binding]; other site 767453001460 Q-loop/lid; other site 767453001461 ABC transporter signature motif; other site 767453001462 Walker B; other site 767453001463 D-loop; other site 767453001464 H-loop/switch region; other site 767453001465 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 767453001466 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 767453001467 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 767453001468 Walker A/P-loop; other site 767453001469 ATP binding site [chemical binding]; other site 767453001470 Q-loop/lid; other site 767453001471 ABC transporter signature motif; other site 767453001472 Walker B; other site 767453001473 D-loop; other site 767453001474 H-loop/switch region; other site 767453001475 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 767453001476 Beta-lactamase; Region: Beta-lactamase; pfam00144 767453001477 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 767453001478 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 767453001479 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 767453001480 putative active site [active] 767453001481 catalytic site [active] 767453001482 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 767453001483 putative active site [active] 767453001484 catalytic site [active] 767453001485 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 767453001486 catalytic triad [active] 767453001487 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 767453001488 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767453001489 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 767453001490 thymidine kinase; Provisional; Region: PRK04296 767453001491 peptide chain release factor 1; Validated; Region: prfA; PRK00591 767453001492 This domain is found in peptide chain release factors; Region: PCRF; smart00937 767453001493 RF-1 domain; Region: RF-1; pfam00472 767453001494 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 767453001495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767453001496 S-adenosylmethionine binding site [chemical binding]; other site 767453001497 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 767453001498 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 767453001499 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 767453001500 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 767453001501 dimer interface [polypeptide binding]; other site 767453001502 active site 767453001503 glycine-pyridoxal phosphate binding site [chemical binding]; other site 767453001504 folate binding site [chemical binding]; other site 767453001505 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767453001506 active site 767453001507 YibE/F-like protein; Region: YibE_F; pfam07907 767453001508 YibE/F-like protein; Region: YibE_F; cl02259 767453001509 uracil transporter; Provisional; Region: PRK10720 767453001510 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 767453001511 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 767453001512 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 767453001513 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 767453001514 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 767453001515 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 767453001516 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 767453001517 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 767453001518 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 767453001519 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 767453001520 beta subunit interaction interface [polypeptide binding]; other site 767453001521 Walker A motif; other site 767453001522 ATP binding site [chemical binding]; other site 767453001523 Walker B motif; other site 767453001524 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 767453001525 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 767453001526 core domain interface [polypeptide binding]; other site 767453001527 delta subunit interface [polypeptide binding]; other site 767453001528 epsilon subunit interface [polypeptide binding]; other site 767453001529 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 767453001530 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 767453001531 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 767453001532 alpha subunit interaction interface [polypeptide binding]; other site 767453001533 Walker A motif; other site 767453001534 ATP binding site [chemical binding]; other site 767453001535 Walker B motif; other site 767453001536 inhibitor binding site; inhibition site 767453001537 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 767453001538 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 767453001539 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 767453001540 gamma subunit interface [polypeptide binding]; other site 767453001541 epsilon subunit interface [polypeptide binding]; other site 767453001542 LBP interface [polypeptide binding]; other site 767453001543 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 767453001544 rod shape-determining protein MreB; Provisional; Region: PRK13930 767453001545 MreB and similar proteins; Region: MreB_like; cd10225 767453001546 nucleotide binding site [chemical binding]; other site 767453001547 Mg binding site [ion binding]; other site 767453001548 putative protofilament interaction site [polypeptide binding]; other site 767453001549 RodZ interaction site [polypeptide binding]; other site 767453001550 Haemolytic domain; Region: Haemolytic; cl00506 767453001551 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 767453001552 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 767453001553 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 767453001554 lipoyl-biotinyl attachment site [posttranslational modification]; other site 767453001555 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 767453001556 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 767453001557 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 767453001558 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 767453001559 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453001560 Helix-turn-helix domain; Region: HTH_38; pfam13936 767453001561 Integrase core domain; Region: rve; pfam00665 767453001562 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767453001563 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767453001564 non-specific DNA binding site [nucleotide binding]; other site 767453001565 salt bridge; other site 767453001566 sequence-specific DNA binding site [nucleotide binding]; other site 767453001567 Tetratricopeptide repeat; Region: TPR_12; pfam13424 767453001568 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767453001569 binding surface 767453001570 TPR motif; other site 767453001571 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 767453001572 Ligand Binding Site [chemical binding]; other site 767453001573 recombination factor protein RarA; Reviewed; Region: PRK13342 767453001574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767453001575 Walker A motif; other site 767453001576 ATP binding site [chemical binding]; other site 767453001577 Walker B motif; other site 767453001578 arginine finger; other site 767453001579 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 767453001580 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 767453001581 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 767453001582 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 767453001583 active site 767453001584 metal binding site [ion binding]; metal-binding site 767453001585 Uncharacterized conserved protein [Function unknown]; Region: COG1284 767453001586 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 767453001587 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 767453001588 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 767453001589 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 767453001590 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 767453001591 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767453001592 RNA binding surface [nucleotide binding]; other site 767453001593 septation ring formation regulator EzrA; Provisional; Region: PRK04778 767453001594 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 767453001595 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 767453001596 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767453001597 catalytic residue [active] 767453001598 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 767453001599 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 767453001600 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 767453001601 Ligand Binding Site [chemical binding]; other site 767453001602 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 767453001603 fructuronate transporter; Provisional; Region: PRK10034; cl15264 767453001604 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 767453001605 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767453001606 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 767453001607 dimer interface [polypeptide binding]; other site 767453001608 catalytic triad [active] 767453001609 peroxidatic and resolving cysteines [active] 767453001610 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 767453001611 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767453001612 active site 767453001613 HIGH motif; other site 767453001614 nucleotide binding site [chemical binding]; other site 767453001615 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 767453001616 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 767453001617 active site 767453001618 KMSKS motif; other site 767453001619 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 767453001620 tRNA binding surface [nucleotide binding]; other site 767453001621 anticodon binding site; other site 767453001622 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 767453001623 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 767453001624 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767453001625 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767453001626 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 767453001627 MPN+ (JAMM) motif; other site 767453001628 Zinc-binding site [ion binding]; other site 767453001629 rod shape-determining protein MreB; Provisional; Region: PRK13927 767453001630 MreB and similar proteins; Region: MreB_like; cd10225 767453001631 nucleotide binding site [chemical binding]; other site 767453001632 Mg binding site [ion binding]; other site 767453001633 putative protofilament interaction site [polypeptide binding]; other site 767453001634 RodZ interaction site [polypeptide binding]; other site 767453001635 rod shape-determining protein MreC; Provisional; Region: PRK13922 767453001636 rod shape-determining protein MreC; Region: MreC; pfam04085 767453001637 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 767453001638 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 767453001639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767453001640 dimer interface [polypeptide binding]; other site 767453001641 conserved gate region; other site 767453001642 putative PBP binding loops; other site 767453001643 ABC-ATPase subunit interface; other site 767453001644 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767453001645 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767453001646 Walker A/P-loop; other site 767453001647 ATP binding site [chemical binding]; other site 767453001648 Q-loop/lid; other site 767453001649 ABC transporter signature motif; other site 767453001650 Walker B; other site 767453001651 D-loop; other site 767453001652 H-loop/switch region; other site 767453001653 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767453001654 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767453001655 substrate binding pocket [chemical binding]; other site 767453001656 membrane-bound complex binding site; other site 767453001657 hinge residues; other site 767453001658 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 767453001659 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 767453001660 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 767453001661 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 767453001662 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 767453001663 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 767453001664 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767453001665 non-specific DNA binding site [nucleotide binding]; other site 767453001666 salt bridge; other site 767453001667 sequence-specific DNA binding site [nucleotide binding]; other site 767453001668 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 767453001669 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 767453001670 competence damage-inducible protein A; Provisional; Region: PRK00549 767453001671 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 767453001672 putative MPT binding site; other site 767453001673 Competence-damaged protein; Region: CinA; pfam02464 767453001674 recombinase A; Provisional; Region: recA; PRK09354 767453001675 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 767453001676 hexamer interface [polypeptide binding]; other site 767453001677 Walker A motif; other site 767453001678 ATP binding site [chemical binding]; other site 767453001679 Walker B motif; other site 767453001680 phosphodiesterase; Provisional; Region: PRK12704 767453001681 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767453001682 Zn2+ binding site [ion binding]; other site 767453001683 Mg2+ binding site [ion binding]; other site 767453001684 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 767453001685 MutS domain I; Region: MutS_I; pfam01624 767453001686 MutS domain II; Region: MutS_II; pfam05188 767453001687 MutS domain III; Region: MutS_III; pfam05192 767453001688 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 767453001689 Walker A/P-loop; other site 767453001690 ATP binding site [chemical binding]; other site 767453001691 Q-loop/lid; other site 767453001692 ABC transporter signature motif; other site 767453001693 Walker B; other site 767453001694 D-loop; other site 767453001695 H-loop/switch region; other site 767453001696 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 767453001697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767453001698 ATP binding site [chemical binding]; other site 767453001699 Mg2+ binding site [ion binding]; other site 767453001700 G-X-G motif; other site 767453001701 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 767453001702 ATP binding site [chemical binding]; other site 767453001703 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 767453001704 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 767453001705 RuvA N terminal domain; Region: RuvA_N; pfam01330 767453001706 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 767453001707 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 767453001708 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767453001709 Walker A motif; other site 767453001710 ATP binding site [chemical binding]; other site 767453001711 Walker B motif; other site 767453001712 arginine finger; other site 767453001713 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 767453001714 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 767453001715 Preprotein translocase subunit; Region: YajC; pfam02699 767453001716 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 767453001717 DHH family; Region: DHH; pfam01368 767453001718 DHHA1 domain; Region: DHHA1; pfam02272 767453001719 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 767453001720 DEAD-like helicases superfamily; Region: DEXDc; smart00487 767453001721 ATP binding site [chemical binding]; other site 767453001722 Mg++ binding site [ion binding]; other site 767453001723 motif III; other site 767453001724 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767453001725 nucleotide binding region [chemical binding]; other site 767453001726 ATP-binding site [chemical binding]; other site 767453001727 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 767453001728 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 767453001729 motif 1; other site 767453001730 active site 767453001731 motif 2; other site 767453001732 motif 3; other site 767453001733 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 767453001734 DHHA1 domain; Region: DHHA1; pfam02272 767453001735 hypothetical protein; Provisional; Region: PRK05473 767453001736 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 767453001737 hypothetical protein; Provisional; Region: PRK13678 767453001738 ribonuclease HIII; Provisional; Region: PRK00996 767453001739 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 767453001740 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 767453001741 RNA/DNA hybrid binding site [nucleotide binding]; other site 767453001742 active site 767453001743 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 767453001744 MutS domain III; Region: MutS_III; pfam05192 767453001745 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767453001746 Walker A/P-loop; other site 767453001747 ATP binding site [chemical binding]; other site 767453001748 Q-loop/lid; other site 767453001749 ABC transporter signature motif; other site 767453001750 Walker B; other site 767453001751 D-loop; other site 767453001752 H-loop/switch region; other site 767453001753 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 767453001754 Smr domain; Region: Smr; pfam01713 767453001755 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 767453001756 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 767453001757 catalytic residues [active] 767453001758 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 767453001759 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 767453001760 putative ion selectivity filter; other site 767453001761 putative pore gating glutamate residue; other site 767453001762 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 767453001763 glutamate racemase; Provisional; Region: PRK00865 767453001764 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 767453001765 active site 767453001766 dimerization interface [polypeptide binding]; other site 767453001767 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 767453001768 active site 767453001769 metal binding site [ion binding]; metal-binding site 767453001770 homotetramer interface [polypeptide binding]; other site 767453001771 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 767453001772 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 767453001773 active site 767453001774 motif I; other site 767453001775 motif II; other site 767453001776 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 767453001777 Mechanosensitive ion channel; Region: MS_channel; pfam00924 767453001778 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 767453001779 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 767453001780 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 767453001781 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 767453001782 active site 767453001783 catabolite control protein A; Region: ccpA; TIGR01481 767453001784 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767453001785 DNA binding site [nucleotide binding] 767453001786 domain linker motif; other site 767453001787 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 767453001788 dimerization interface [polypeptide binding]; other site 767453001789 effector binding site; other site 767453001790 hypothetical protein; Validated; Region: PRK00110 767453001791 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767453001792 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 767453001793 NlpC/P60 family; Region: NLPC_P60; pfam00877 767453001794 Type II/IV secretion system protein; Region: T2SE; pfam00437 767453001795 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 767453001796 Walker A motif; other site 767453001797 ATP binding site [chemical binding]; other site 767453001798 Walker B motif; other site 767453001799 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 767453001800 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 767453001801 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 767453001802 Methyltransferase domain; Region: Methyltransf_26; pfam13659 767453001803 S-adenosylmethionine binding site [chemical binding]; other site 767453001804 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 767453001805 propionate/acetate kinase; Provisional; Region: PRK12379 767453001806 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 767453001807 putative active site [active] 767453001808 putative metal binding site [ion binding]; other site 767453001809 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 767453001810 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 767453001811 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767453001812 active site 767453001813 motif I; other site 767453001814 motif II; other site 767453001815 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767453001816 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 767453001817 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 767453001818 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 767453001819 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 767453001820 adaptor protein; Provisional; Region: PRK02315 767453001821 Competence protein CoiA-like family; Region: CoiA; cl11541 767453001822 Thioredoxin; Region: Thioredoxin_5; pfam13743 767453001823 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 767453001824 synthetase active site [active] 767453001825 NTP binding site [chemical binding]; other site 767453001826 metal binding site [ion binding]; metal-binding site 767453001827 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 767453001828 ATP-NAD kinase; Region: NAD_kinase; pfam01513 767453001829 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 767453001830 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 767453001831 active site 767453001832 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 767453001833 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 767453001834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767453001835 S-adenosylmethionine binding site [chemical binding]; other site 767453001836 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 767453001837 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 767453001838 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 767453001839 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 767453001840 cell division protein MraZ; Reviewed; Region: PRK00326 767453001841 MraZ protein; Region: MraZ; pfam02381 767453001842 MraZ protein; Region: MraZ; pfam02381 767453001843 MraW methylase family; Region: Methyltransf_5; pfam01795 767453001844 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 767453001845 Cell division protein FtsL; Region: FtsL; cl11433 767453001846 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 767453001847 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 767453001848 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 767453001849 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 767453001850 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 767453001851 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 767453001852 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 767453001853 Mg++ binding site [ion binding]; other site 767453001854 putative catalytic motif [active] 767453001855 putative substrate binding site [chemical binding]; other site 767453001856 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 767453001857 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 767453001858 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767453001859 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767453001860 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 767453001861 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 767453001862 active site 767453001863 homodimer interface [polypeptide binding]; other site 767453001864 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 767453001865 Cell division protein FtsQ; Region: FtsQ; pfam03799 767453001866 cell division protein FtsA; Region: ftsA; TIGR01174 767453001867 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 767453001868 nucleotide binding site [chemical binding]; other site 767453001869 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 767453001870 Cell division protein FtsA; Region: FtsA; pfam14450 767453001871 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 767453001872 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 767453001873 nucleotide binding site [chemical binding]; other site 767453001874 SulA interaction site; other site 767453001875 Protein of unknown function (DUF552); Region: DUF552; pfam04472 767453001876 YGGT family; Region: YGGT; pfam02325 767453001877 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 767453001878 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767453001879 RNA binding surface [nucleotide binding]; other site 767453001880 DivIVA protein; Region: DivIVA; pfam05103 767453001881 DivIVA domain; Region: DivI1A_domain; TIGR03544 767453001882 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 767453001883 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767453001884 active site 767453001885 HIGH motif; other site 767453001886 nucleotide binding site [chemical binding]; other site 767453001887 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 767453001888 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 767453001889 active site 767453001890 KMSKS motif; other site 767453001891 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 767453001892 tRNA binding surface [nucleotide binding]; other site 767453001893 anticodon binding site; other site 767453001894 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 767453001895 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 767453001896 DNA-binding site [nucleotide binding]; DNA binding site 767453001897 RNA-binding motif; other site 767453001898 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 767453001899 dimer interface [polypeptide binding]; other site 767453001900 ADP-ribose binding site [chemical binding]; other site 767453001901 active site 767453001902 nudix motif; other site 767453001903 metal binding site [ion binding]; metal-binding site 767453001904 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 767453001905 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 767453001906 Putative amino acid metabolism; Region: DUF1831; pfam08866 767453001907 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 767453001908 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 767453001909 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453001910 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453001911 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453001912 Probable transposase; Region: OrfB_IS605; pfam01385 767453001913 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453001914 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 767453001915 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 767453001916 active site 767453001917 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 767453001918 tetramer (dimer of dimers) interface [polypeptide binding]; other site 767453001919 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 767453001920 NAD binding site [chemical binding]; other site 767453001921 dimer interface [polypeptide binding]; other site 767453001922 substrate binding site [chemical binding]; other site 767453001923 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767453001924 catalytic core [active] 767453001925 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 767453001926 TPR motif; other site 767453001927 Tetratricopeptide repeat; Region: TPR_12; pfam13424 767453001928 binding surface 767453001929 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767453001930 binding surface 767453001931 TPR motif; other site 767453001932 TPR repeat; Region: TPR_11; pfam13414 767453001933 Tetratricopeptide repeat; Region: TPR_16; pfam13432 767453001934 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 767453001935 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 767453001936 AAA domain; Region: AAA_30; pfam13604 767453001937 Family description; Region: UvrD_C_2; pfam13538 767453001938 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 767453001939 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 767453001940 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767453001941 active site 767453001942 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 767453001943 ArsC family; Region: ArsC; pfam03960 767453001944 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 767453001945 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 767453001946 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 767453001947 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 767453001948 active site 767453001949 catalytic residues [active] 767453001950 metal binding site [ion binding]; metal-binding site 767453001951 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 767453001952 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 767453001953 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 767453001954 active site 767453001955 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 767453001956 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 767453001957 G1 box; other site 767453001958 putative GEF interaction site [polypeptide binding]; other site 767453001959 GTP/Mg2+ binding site [chemical binding]; other site 767453001960 Switch I region; other site 767453001961 G2 box; other site 767453001962 G3 box; other site 767453001963 Switch II region; other site 767453001964 G4 box; other site 767453001965 G5 box; other site 767453001966 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 767453001967 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 767453001968 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 767453001969 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 767453001970 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 767453001971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767453001972 S-adenosylmethionine binding site [chemical binding]; other site 767453001973 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 767453001974 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 767453001975 active site 767453001976 (T/H)XGH motif; other site 767453001977 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 767453001978 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 767453001979 SLBB domain; Region: SLBB; pfam10531 767453001980 comEA protein; Region: comE; TIGR01259 767453001981 Helix-hairpin-helix motif; Region: HHH; pfam00633 767453001982 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 767453001983 catalytic motif [active] 767453001984 Zn binding site [ion binding]; other site 767453001985 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 767453001986 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 767453001987 Competence protein; Region: Competence; pfam03772 767453001988 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 767453001989 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 767453001990 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 767453001991 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 767453001992 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 767453001993 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 767453001994 16S/18S rRNA binding site [nucleotide binding]; other site 767453001995 S13e-L30e interaction site [polypeptide binding]; other site 767453001996 25S rRNA binding site [nucleotide binding]; other site 767453001997 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453001998 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453001999 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453002000 Probable transposase; Region: OrfB_IS605; pfam01385 767453002001 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453002002 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 767453002003 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 767453002004 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 767453002005 elongation factor Tu; Reviewed; Region: PRK00049 767453002006 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 767453002007 G1 box; other site 767453002008 GEF interaction site [polypeptide binding]; other site 767453002009 GTP/Mg2+ binding site [chemical binding]; other site 767453002010 Switch I region; other site 767453002011 G2 box; other site 767453002012 G3 box; other site 767453002013 Switch II region; other site 767453002014 G4 box; other site 767453002015 G5 box; other site 767453002016 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 767453002017 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 767453002018 Antibiotic Binding Site [chemical binding]; other site 767453002019 trigger factor; Provisional; Region: tig; PRK01490 767453002020 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 767453002021 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 767453002022 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 767453002023 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 767453002024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767453002025 Walker A motif; other site 767453002026 ATP binding site [chemical binding]; other site 767453002027 Walker B motif; other site 767453002028 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 767453002029 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 767453002030 G1 box; other site 767453002031 GTP/Mg2+ binding site [chemical binding]; other site 767453002032 Switch I region; other site 767453002033 G2 box; other site 767453002034 G3 box; other site 767453002035 Switch II region; other site 767453002036 G4 box; other site 767453002037 G5 box; other site 767453002038 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 767453002039 putative metal binding site [ion binding]; other site 767453002040 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 767453002041 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 767453002042 Walker A/P-loop; other site 767453002043 ATP binding site [chemical binding]; other site 767453002044 Q-loop/lid; other site 767453002045 ABC transporter signature motif; other site 767453002046 Walker B; other site 767453002047 D-loop; other site 767453002048 H-loop/switch region; other site 767453002049 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 767453002050 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 767453002051 GIY-YIG motif/motif A; other site 767453002052 active site 767453002053 catalytic site [active] 767453002054 putative DNA binding site [nucleotide binding]; other site 767453002055 metal binding site [ion binding]; metal-binding site 767453002056 UvrB/uvrC motif; Region: UVR; pfam02151 767453002057 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 767453002058 GTPase CgtA; Reviewed; Region: obgE; PRK12297 767453002059 GTP1/OBG; Region: GTP1_OBG; pfam01018 767453002060 Obg GTPase; Region: Obg; cd01898 767453002061 G1 box; other site 767453002062 GTP/Mg2+ binding site [chemical binding]; other site 767453002063 Switch I region; other site 767453002064 G2 box; other site 767453002065 G3 box; other site 767453002066 Switch II region; other site 767453002067 G4 box; other site 767453002068 G5 box; other site 767453002069 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 767453002070 ribonuclease Z; Region: RNase_Z; TIGR02651 767453002071 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 767453002072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767453002073 NAD(P) binding site [chemical binding]; other site 767453002074 active site 767453002075 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 767453002076 DHH family; Region: DHH; pfam01368 767453002077 DHHA1 domain; Region: DHHA1; pfam02272 767453002078 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 767453002079 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767453002080 active site 767453002081 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 767453002082 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 767453002083 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 767453002084 homodimer interface [polypeptide binding]; other site 767453002085 ligand binding site [chemical binding]; other site 767453002086 NAD binding site [chemical binding]; other site 767453002087 catalytic site [active] 767453002088 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 767453002089 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453002090 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453002091 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453002092 Probable transposase; Region: OrfB_IS605; pfam01385 767453002093 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453002094 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 767453002095 Uncharacterized conserved protein [Function unknown]; Region: COG1359 767453002096 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 767453002097 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 767453002098 dimer interface [polypeptide binding]; other site 767453002099 active site 767453002100 metal binding site [ion binding]; metal-binding site 767453002101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767453002102 short chain dehydrogenase; Provisional; Region: PRK06940 767453002103 NAD(P) binding site [chemical binding]; other site 767453002104 active site 767453002105 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 767453002106 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 767453002107 putative trimer interface [polypeptide binding]; other site 767453002108 putative CoA binding site [chemical binding]; other site 767453002109 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 767453002110 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453002111 Integrase core domain; Region: rve; pfam00665 767453002112 Helix-turn-helix domain; Region: HTH_38; pfam13936 767453002113 preprotein translocase subunit SecA; Reviewed; Region: PRK13107 767453002114 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 767453002115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453002116 asparagine synthetase B; Provisional; Region: asnB; PRK09431 767453002117 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 767453002118 active site 767453002119 dimer interface [polypeptide binding]; other site 767453002120 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 767453002121 Ligand Binding Site [chemical binding]; other site 767453002122 Molecular Tunnel; other site 767453002123 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453002124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453002125 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453002126 Probable transposase; Region: OrfB_IS605; pfam01385 767453002127 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453002128 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 767453002129 Transcriptional regulators [Transcription]; Region: PurR; COG1609 767453002130 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767453002131 DNA binding site [nucleotide binding] 767453002132 domain linker motif; other site 767453002133 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 767453002134 dimerization interface [polypeptide binding]; other site 767453002135 ligand binding site [chemical binding]; other site 767453002136 sodium binding site [ion binding]; other site 767453002137 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 767453002138 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453002139 Integrase core domain; Region: rve; pfam00665 767453002140 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453002141 Helix-turn-helix domain; Region: HTH_38; pfam13936 767453002142 Integrase core domain; Region: rve; pfam00665 767453002143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767453002144 Transposase; Region: HTH_Tnp_1; cl17663 767453002145 putative transposase OrfB; Reviewed; Region: PHA02517 767453002146 HTH-like domain; Region: HTH_21; pfam13276 767453002147 Integrase core domain; Region: rve; pfam00665 767453002148 Integrase core domain; Region: rve_3; pfam13683 767453002149 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 767453002150 active site 767453002151 NTP binding site [chemical binding]; other site 767453002152 metal binding triad [ion binding]; metal-binding site 767453002153 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453002154 Helix-turn-helix domain; Region: HTH_38; pfam13936 767453002155 Integrase core domain; Region: rve; pfam00665 767453002156 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767453002157 MULE transposase domain; Region: MULE; pfam10551 767453002158 HTH-like domain; Region: HTH_21; pfam13276 767453002159 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767453002160 Helix-turn-helix domain; Region: HTH_28; pfam13518 767453002161 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 767453002162 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 767453002163 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 767453002164 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 767453002165 active site 767453002166 catalytic residues [active] 767453002167 metal binding site [ion binding]; metal-binding site 767453002168 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 767453002169 HTH-like domain; Region: HTH_21; pfam13276 767453002170 Integrase core domain; Region: rve; pfam00665 767453002171 Integrase core domain; Region: rve_3; cl15866 767453002172 Transposase; Region: HTH_Tnp_1; cl17663 767453002173 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767453002174 MULE transposase domain; Region: MULE; pfam10551 767453002175 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 767453002176 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 767453002177 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 767453002178 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 767453002179 legume lectins; Region: lectin_L-type; cl14058 767453002180 homotetramer interaction site [polypeptide binding]; other site 767453002181 carbohydrate binding site [chemical binding]; other site 767453002182 metal binding site [ion binding]; metal-binding site 767453002183 MucBP domain; Region: MucBP; pfam06458 767453002184 MucBP domain; Region: MucBP; pfam06458 767453002185 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767453002186 Helix-turn-helix domain; Region: HTH_28; pfam13518 767453002187 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 767453002188 HTH-like domain; Region: HTH_21; pfam13276 767453002189 Integrase core domain; Region: rve; pfam00665 767453002190 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453002191 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453002192 Probable transposase; Region: OrfB_IS605; pfam01385 767453002193 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453002194 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453002195 Uncharacterized conserved protein [Function unknown]; Region: COG1556 767453002196 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 767453002197 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 767453002198 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 767453002199 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 767453002200 Cysteine-rich domain; Region: CCG; pfam02754 767453002201 Cysteine-rich domain; Region: CCG; pfam02754 767453002202 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 767453002203 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 767453002204 dimer interface [polypeptide binding]; other site 767453002205 active site 767453002206 LexA repressor; Validated; Region: PRK00215 767453002207 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 767453002208 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 767453002209 Catalytic site [active] 767453002210 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 767453002211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 767453002212 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 767453002213 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 767453002214 putative acyl-acceptor binding pocket; other site 767453002215 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 767453002216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767453002217 S-adenosylmethionine binding site [chemical binding]; other site 767453002218 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 767453002219 GIY-YIG motif/motif A; other site 767453002220 putative active site [active] 767453002221 putative metal binding site [ion binding]; other site 767453002222 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 767453002223 rRNA interaction site [nucleotide binding]; other site 767453002224 S8 interaction site; other site 767453002225 putative laminin-1 binding site; other site 767453002226 elongation factor Ts; Provisional; Region: tsf; PRK09377 767453002227 UBA/TS-N domain; Region: UBA; pfam00627 767453002228 Elongation factor TS; Region: EF_TS; pfam00889 767453002229 Elongation factor TS; Region: EF_TS; pfam00889 767453002230 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 767453002231 putative nucleotide binding site [chemical binding]; other site 767453002232 uridine monophosphate binding site [chemical binding]; other site 767453002233 homohexameric interface [polypeptide binding]; other site 767453002234 ribosome recycling factor; Reviewed; Region: frr; PRK00083 767453002235 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 767453002236 hinge region; other site 767453002237 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 767453002238 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 767453002239 catalytic residue [active] 767453002240 putative FPP diphosphate binding site; other site 767453002241 putative FPP binding hydrophobic cleft; other site 767453002242 dimer interface [polypeptide binding]; other site 767453002243 putative IPP diphosphate binding site; other site 767453002244 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 767453002245 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 767453002246 RIP metalloprotease RseP; Region: TIGR00054 767453002247 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 767453002248 active site 767453002249 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 767453002250 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 767453002251 protein binding site [polypeptide binding]; other site 767453002252 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 767453002253 putative substrate binding region [chemical binding]; other site 767453002254 prolyl-tRNA synthetase; Provisional; Region: PRK09194 767453002255 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 767453002256 dimer interface [polypeptide binding]; other site 767453002257 motif 1; other site 767453002258 active site 767453002259 motif 2; other site 767453002260 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 767453002261 putative deacylase active site [active] 767453002262 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 767453002263 active site 767453002264 motif 3; other site 767453002265 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 767453002266 anticodon binding site; other site 767453002267 DNA polymerase III PolC; Validated; Region: polC; PRK00448 767453002268 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 767453002269 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 767453002270 generic binding surface II; other site 767453002271 generic binding surface I; other site 767453002272 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 767453002273 active site 767453002274 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 767453002275 active site 767453002276 catalytic site [active] 767453002277 substrate binding site [chemical binding]; other site 767453002278 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 767453002279 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 767453002280 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 767453002281 inhibitor-cofactor binding pocket; inhibition site 767453002282 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767453002283 catalytic residue [active] 767453002284 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 767453002285 nucleotide binding site [chemical binding]; other site 767453002286 N-acetyl-L-glutamate binding site [chemical binding]; other site 767453002287 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 767453002288 heterotetramer interface [polypeptide binding]; other site 767453002289 active site pocket [active] 767453002290 cleavage site 767453002291 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 767453002292 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 767453002293 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 767453002294 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 767453002295 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 767453002296 catalytic site [active] 767453002297 subunit interface [polypeptide binding]; other site 767453002298 carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369 767453002299 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767453002300 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 767453002301 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 767453002302 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767453002303 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767453002304 Sm and related proteins; Region: Sm_like; cl00259 767453002305 ribosome maturation protein RimP; Reviewed; Region: PRK00092 767453002306 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 767453002307 putative oligomer interface [polypeptide binding]; other site 767453002308 putative RNA binding site [nucleotide binding]; other site 767453002309 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 767453002310 NusA N-terminal domain; Region: NusA_N; pfam08529 767453002311 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 767453002312 RNA binding site [nucleotide binding]; other site 767453002313 homodimer interface [polypeptide binding]; other site 767453002314 NusA-like KH domain; Region: KH_5; pfam13184 767453002315 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 767453002316 G-X-X-G motif; other site 767453002317 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 767453002318 putative RNA binding cleft [nucleotide binding]; other site 767453002319 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 767453002320 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 767453002321 translation initiation factor IF-2; Region: IF-2; TIGR00487 767453002322 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 767453002323 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 767453002324 G1 box; other site 767453002325 putative GEF interaction site [polypeptide binding]; other site 767453002326 GTP/Mg2+ binding site [chemical binding]; other site 767453002327 Switch I region; other site 767453002328 G2 box; other site 767453002329 G3 box; other site 767453002330 Switch II region; other site 767453002331 G4 box; other site 767453002332 G5 box; other site 767453002333 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 767453002334 Translation-initiation factor 2; Region: IF-2; pfam11987 767453002335 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 767453002336 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 767453002337 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 767453002338 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 767453002339 RNA binding site [nucleotide binding]; other site 767453002340 active site 767453002341 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 767453002342 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 767453002343 active site 767453002344 Riboflavin kinase; Region: Flavokinase; smart00904 767453002345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453002346 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767453002347 putative substrate translocation pore; other site 767453002348 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767453002349 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453002350 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453002351 Probable transposase; Region: OrfB_IS605; pfam01385 767453002352 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453002353 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453002354 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767453002355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453002356 putative substrate translocation pore; other site 767453002357 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 767453002358 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 767453002359 Ca binding site [ion binding]; other site 767453002360 active site 767453002361 catalytic site [active] 767453002362 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 767453002363 Transcriptional regulators [Transcription]; Region: PurR; COG1609 767453002364 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767453002365 DNA binding site [nucleotide binding] 767453002366 domain linker motif; other site 767453002367 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 767453002368 dimerization interface [polypeptide binding]; other site 767453002369 ligand binding site [chemical binding]; other site 767453002370 Y-family of DNA polymerases; Region: PolY; cl12025 767453002371 active site 767453002372 DNA polymerase IV; Reviewed; Region: PRK03103 767453002373 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 767453002374 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 767453002375 dimer interface [polypeptide binding]; other site 767453002376 active site 767453002377 metal binding site [ion binding]; metal-binding site 767453002378 Helix-turn-helix domain; Region: HTH_38; pfam13936 767453002379 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453002380 Integrase core domain; Region: rve; pfam00665 767453002381 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 767453002382 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 767453002383 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 767453002384 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 767453002385 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 767453002386 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767453002387 Helix-turn-helix domain; Region: HTH_28; pfam13518 767453002388 HTH-like domain; Region: HTH_21; pfam13276 767453002389 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767453002390 Transposase; Region: HTH_Tnp_1; cl17663 767453002391 putative transposase OrfB; Reviewed; Region: PHA02517 767453002392 HTH-like domain; Region: HTH_21; pfam13276 767453002393 Integrase core domain; Region: rve; pfam00665 767453002394 Integrase core domain; Region: rve_3; pfam13683 767453002395 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453002396 Integrase core domain; Region: rve; pfam00665 767453002397 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 767453002398 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 767453002399 GrpE; Region: GrpE; pfam01025 767453002400 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 767453002401 dimer interface [polypeptide binding]; other site 767453002402 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 767453002403 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 767453002404 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 767453002405 nucleotide binding site [chemical binding]; other site 767453002406 NEF interaction site [polypeptide binding]; other site 767453002407 SBD interface [polypeptide binding]; other site 767453002408 chaperone protein DnaJ; Provisional; Region: PRK14276 767453002409 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 767453002410 HSP70 interaction site [polypeptide binding]; other site 767453002411 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 767453002412 substrate binding site [polypeptide binding]; other site 767453002413 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 767453002414 Zn binding sites [ion binding]; other site 767453002415 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 767453002416 dimer interface [polypeptide binding]; other site 767453002417 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 767453002418 conserved cys residue [active] 767453002419 histidinol-phosphatase; Reviewed; Region: PRK08123 767453002420 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 767453002421 active site 767453002422 dimer interface [polypeptide binding]; other site 767453002423 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 767453002424 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 767453002425 dimer interface [polypeptide binding]; other site 767453002426 motif 1; other site 767453002427 active site 767453002428 motif 2; other site 767453002429 motif 3; other site 767453002430 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 767453002431 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 767453002432 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 767453002433 histidinol dehydrogenase; Region: hisD; TIGR00069 767453002434 NAD binding site [chemical binding]; other site 767453002435 dimerization interface [polypeptide binding]; other site 767453002436 product binding site; other site 767453002437 substrate binding site [chemical binding]; other site 767453002438 zinc binding site [ion binding]; other site 767453002439 catalytic residues [active] 767453002440 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 767453002441 putative active site pocket [active] 767453002442 4-fold oligomerization interface [polypeptide binding]; other site 767453002443 metal binding residues [ion binding]; metal-binding site 767453002444 3-fold/trimer interface [polypeptide binding]; other site 767453002445 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 767453002446 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 767453002447 putative active site [active] 767453002448 oxyanion strand; other site 767453002449 catalytic triad [active] 767453002450 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 767453002451 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 767453002452 substrate binding site [chemical binding]; other site 767453002453 glutamase interaction surface [polypeptide binding]; other site 767453002454 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; pfam01502 767453002455 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 767453002456 metal binding site [ion binding]; metal-binding site 767453002457 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 767453002458 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767453002459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767453002460 homodimer interface [polypeptide binding]; other site 767453002461 catalytic residue [active] 767453002462 GTP-binding protein LepA; Provisional; Region: PRK05433 767453002463 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 767453002464 G1 box; other site 767453002465 putative GEF interaction site [polypeptide binding]; other site 767453002466 GTP/Mg2+ binding site [chemical binding]; other site 767453002467 Switch I region; other site 767453002468 G2 box; other site 767453002469 G3 box; other site 767453002470 Switch II region; other site 767453002471 G4 box; other site 767453002472 G5 box; other site 767453002473 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 767453002474 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 767453002475 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 767453002476 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767453002477 catalytic core [active] 767453002478 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 767453002479 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767453002480 catalytic residue [active] 767453002481 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 767453002482 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 767453002483 putative ligand binding site [chemical binding]; other site 767453002484 putative NAD binding site [chemical binding]; other site 767453002485 putative catalytic site [active] 767453002486 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 767453002487 L-serine binding site [chemical binding]; other site 767453002488 ACT domain interface; other site 767453002489 Predicted transcriptional regulator [Transcription]; Region: COG1959 767453002490 Transcriptional regulator; Region: Rrf2; pfam02082 767453002491 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 767453002492 homopentamer interface [polypeptide binding]; other site 767453002493 active site 767453002494 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 767453002495 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 767453002496 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 767453002497 dimerization interface [polypeptide binding]; other site 767453002498 active site 767453002499 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 767453002500 Lumazine binding domain; Region: Lum_binding; pfam00677 767453002501 Lumazine binding domain; Region: Lum_binding; pfam00677 767453002502 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 767453002503 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 767453002504 catalytic motif [active] 767453002505 Zn binding site [ion binding]; other site 767453002506 RibD C-terminal domain; Region: RibD_C; cl17279 767453002507 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767453002508 MULE transposase domain; Region: MULE; pfam10551 767453002509 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 767453002510 Double zinc ribbon; Region: DZR; pfam12773 767453002511 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 767453002512 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453002513 Helix-turn-helix domain; Region: HTH_38; pfam13936 767453002514 Integrase core domain; Region: rve; pfam00665 767453002515 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 767453002516 LemA family; Region: LemA; cl00742 767453002517 Peptidase family M48; Region: Peptidase_M48; cl12018 767453002518 Double zinc ribbon; Region: DZR; pfam12773 767453002519 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 767453002520 Protein of unknown function (DUF805); Region: DUF805; pfam05656 767453002521 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 767453002522 HTH-like domain; Region: HTH_21; pfam13276 767453002523 Integrase core domain; Region: rve; pfam00665 767453002524 Integrase core domain; Region: rve_3; cl15866 767453002525 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767453002526 Transposase; Region: HTH_Tnp_1; pfam01527 767453002527 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767453002528 Transposase; Region: HTH_Tnp_1; pfam01527 767453002529 putative transposase OrfB; Reviewed; Region: PHA02517 767453002530 Integrase core domain; Region: rve; pfam00665 767453002531 Integrase core domain; Region: rve_3; pfam13683 767453002532 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767453002533 MULE transposase domain; Region: MULE; pfam10551 767453002534 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767453002535 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453002536 Integrase core domain; Region: rve; pfam00665 767453002537 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 767453002538 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 767453002539 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767453002540 catalytic residue [active] 767453002541 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453002542 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453002543 Probable transposase; Region: OrfB_IS605; pfam01385 767453002544 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453002545 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453002546 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453002547 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453002548 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453002549 Probable transposase; Region: OrfB_IS605; pfam01385 767453002550 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453002551 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 767453002552 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 767453002553 metal binding site [ion binding]; metal-binding site 767453002554 dimer interface [polypeptide binding]; other site 767453002555 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 767453002556 Cadmium resistance transporter; Region: Cad; pfam03596 767453002557 Protein of unknown function (DUF554); Region: DUF554; pfam04474 767453002558 methionine sulfoxide reductase A; Provisional; Region: PRK14054 767453002559 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 767453002560 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 767453002561 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 767453002562 methionine sulfoxide reductase A; Provisional; Region: PRK14054 767453002563 CAAX protease self-immunity; Region: Abi; cl00558 767453002564 Phosphate-starvation-inducible E; Region: PsiE; cl01264 767453002565 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 767453002566 dimer interface [polypeptide binding]; other site 767453002567 substrate binding site [chemical binding]; other site 767453002568 ATP binding site [chemical binding]; other site 767453002569 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 767453002570 thiamine phosphate binding site [chemical binding]; other site 767453002571 active site 767453002572 pyrophosphate binding site [ion binding]; other site 767453002573 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 767453002574 dimer interface [polypeptide binding]; other site 767453002575 substrate binding site [chemical binding]; other site 767453002576 ATP binding site [chemical binding]; other site 767453002577 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 767453002578 substrate binding site [chemical binding]; other site 767453002579 multimerization interface [polypeptide binding]; other site 767453002580 ATP binding site [chemical binding]; other site 767453002581 conserved hypothetical integral membrane protein; Region: TIGR03766 767453002582 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 767453002583 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 767453002584 tetramer (dimer of dimers) interface [polypeptide binding]; other site 767453002585 NAD binding site [chemical binding]; other site 767453002586 dimer interface [polypeptide binding]; other site 767453002587 substrate binding site [chemical binding]; other site 767453002588 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453002589 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453002590 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453002591 Probable transposase; Region: OrfB_IS605; pfam01385 767453002592 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453002593 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 767453002594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767453002595 S-adenosylmethionine binding site [chemical binding]; other site 767453002596 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 767453002597 RNA methyltransferase, RsmE family; Region: TIGR00046 767453002598 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 767453002599 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767453002600 Zn2+ binding site [ion binding]; other site 767453002601 Mg2+ binding site [ion binding]; other site 767453002602 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 767453002603 synthetase active site [active] 767453002604 NTP binding site [chemical binding]; other site 767453002605 metal binding site [ion binding]; metal-binding site 767453002606 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 767453002607 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 767453002608 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 767453002609 putative active site [active] 767453002610 dimerization interface [polypeptide binding]; other site 767453002611 putative tRNAtyr binding site [nucleotide binding]; other site 767453002612 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767453002613 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 767453002614 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 767453002615 homodimer interface [polypeptide binding]; other site 767453002616 substrate-cofactor binding pocket; other site 767453002617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767453002618 catalytic residue [active] 767453002619 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 767453002620 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 767453002621 homodimer interface [polypeptide binding]; other site 767453002622 substrate-cofactor binding pocket; other site 767453002623 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767453002624 catalytic residue [active] 767453002625 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767453002626 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767453002627 substrate binding pocket [chemical binding]; other site 767453002628 membrane-bound complex binding site; other site 767453002629 hinge residues; other site 767453002630 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767453002631 Coenzyme A binding pocket [chemical binding]; other site 767453002632 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 767453002633 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 767453002634 Walker A/P-loop; other site 767453002635 ATP binding site [chemical binding]; other site 767453002636 Q-loop/lid; other site 767453002637 ABC transporter signature motif; other site 767453002638 Walker B; other site 767453002639 D-loop; other site 767453002640 H-loop/switch region; other site 767453002641 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 767453002642 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 767453002643 metal binding site [ion binding]; metal-binding site 767453002644 dimer interface [polypeptide binding]; other site 767453002645 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 767453002646 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 767453002647 tetramer interface [polypeptide binding]; other site 767453002648 active site 767453002649 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 767453002650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767453002651 dimer interface [polypeptide binding]; other site 767453002652 conserved gate region; other site 767453002653 putative PBP binding loops; other site 767453002654 ABC-ATPase subunit interface; other site 767453002655 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 767453002656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767453002657 dimer interface [polypeptide binding]; other site 767453002658 conserved gate region; other site 767453002659 putative PBP binding loops; other site 767453002660 ABC-ATPase subunit interface; other site 767453002661 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 767453002662 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 767453002663 Walker A/P-loop; other site 767453002664 ATP binding site [chemical binding]; other site 767453002665 Q-loop/lid; other site 767453002666 ABC transporter signature motif; other site 767453002667 Walker B; other site 767453002668 D-loop; other site 767453002669 H-loop/switch region; other site 767453002670 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 767453002671 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767453002672 substrate binding pocket [chemical binding]; other site 767453002673 membrane-bound complex binding site; other site 767453002674 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767453002675 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 767453002676 NAD(P) binding site [chemical binding]; other site 767453002677 active site 767453002678 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 767453002679 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 767453002680 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 767453002681 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 767453002682 conserved cys residue [active] 767453002683 S-methylmethionine transporter; Provisional; Region: PRK11387 767453002684 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 767453002685 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 767453002686 Phosphotransferase enzyme family; Region: APH; pfam01636 767453002687 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 767453002688 active site 767453002689 substrate binding site [chemical binding]; other site 767453002690 ATP binding site [chemical binding]; other site 767453002691 Ecdysteroid kinase; Region: EcKinase; cl17738 767453002692 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 767453002693 substrate binding site [chemical binding]; other site 767453002694 Bacterial SH3 domain; Region: SH3_3; cl17532 767453002695 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 767453002696 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 767453002697 active site 767453002698 metal binding site [ion binding]; metal-binding site 767453002699 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 767453002700 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 767453002701 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 767453002702 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 767453002703 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 767453002704 dimer interface [polypeptide binding]; other site 767453002705 motif 1; other site 767453002706 active site 767453002707 motif 2; other site 767453002708 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 767453002709 anticodon binding site; other site 767453002710 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 767453002711 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 767453002712 dimer interface [polypeptide binding]; other site 767453002713 anticodon binding site; other site 767453002714 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 767453002715 homodimer interface [polypeptide binding]; other site 767453002716 motif 1; other site 767453002717 active site 767453002718 motif 2; other site 767453002719 GAD domain; Region: GAD; pfam02938 767453002720 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 767453002721 active site 767453002722 motif 3; other site 767453002723 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 767453002724 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 767453002725 catalytic triad [active] 767453002726 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 767453002727 Yqey-like protein; Region: YqeY; pfam09424 767453002728 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 767453002729 PhoH-like protein; Region: PhoH; pfam02562 767453002730 metal-binding heat shock protein; Provisional; Region: PRK00016 767453002731 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 767453002732 GTPase Era; Reviewed; Region: era; PRK00089 767453002733 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 767453002734 G1 box; other site 767453002735 GTP/Mg2+ binding site [chemical binding]; other site 767453002736 Switch I region; other site 767453002737 G2 box; other site 767453002738 Switch II region; other site 767453002739 G3 box; other site 767453002740 G4 box; other site 767453002741 G5 box; other site 767453002742 Recombination protein O N terminal; Region: RecO_N; pfam11967 767453002743 DNA repair protein RecO; Region: reco; TIGR00613 767453002744 Recombination protein O C terminal; Region: RecO_C; pfam02565 767453002745 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 767453002746 dimer interface [polypeptide binding]; other site 767453002747 motif 1; other site 767453002748 active site 767453002749 motif 2; other site 767453002750 motif 3; other site 767453002751 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 767453002752 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 767453002753 DNA primase; Validated; Region: dnaG; PRK05667 767453002754 CHC2 zinc finger; Region: zf-CHC2; pfam01807 767453002755 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 767453002756 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 767453002757 active site 767453002758 metal binding site [ion binding]; metal-binding site 767453002759 interdomain interaction site; other site 767453002760 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 767453002761 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 767453002762 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 767453002763 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 767453002764 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 767453002765 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 767453002766 DNA binding residues [nucleotide binding] 767453002767 DDE domain; Region: DDE_Tnp_IS240; pfam13610 767453002768 Integrase core domain; Region: rve; pfam00665 767453002769 Integrase core domain; Region: rve_3; pfam13683 767453002770 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767453002771 Transposase; Region: HTH_Tnp_1; pfam01527 767453002772 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 767453002773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 767453002774 putative transposase OrfB; Reviewed; Region: PHA02517 767453002775 HTH-like domain; Region: HTH_21; pfam13276 767453002776 Integrase core domain; Region: rve; pfam00665 767453002777 Integrase core domain; Region: rve_3; pfam13683 767453002778 Transposase; Region: HTH_Tnp_1; cl17663 767453002779 Helix-turn-helix domain; Region: HTH_38; pfam13936 767453002780 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453002781 Integrase core domain; Region: rve; pfam00665 767453002782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453002783 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 767453002784 putative substrate translocation pore; other site 767453002785 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 767453002786 ApbE family; Region: ApbE; pfam02424 767453002787 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 767453002788 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 767453002789 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 767453002790 aspartate kinase; Reviewed; Region: PRK09034 767453002791 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 767453002792 putative catalytic residues [active] 767453002793 putative nucleotide binding site [chemical binding]; other site 767453002794 putative aspartate binding site [chemical binding]; other site 767453002795 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 767453002796 allosteric regulatory residue; other site 767453002797 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 767453002798 diaminopimelate decarboxylase; Region: lysA; TIGR01048 767453002799 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 767453002800 active site 767453002801 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 767453002802 substrate binding site [chemical binding]; other site 767453002803 catalytic residues [active] 767453002804 dimer interface [polypeptide binding]; other site 767453002805 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 767453002806 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 767453002807 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 767453002808 active site 767453002809 trimer interface [polypeptide binding]; other site 767453002810 substrate binding site [chemical binding]; other site 767453002811 CoA binding site [chemical binding]; other site 767453002812 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 767453002813 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 767453002814 metal binding site [ion binding]; metal-binding site 767453002815 putative dimer interface [polypeptide binding]; other site 767453002816 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 767453002817 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 767453002818 dimer interface [polypeptide binding]; other site 767453002819 active site 767453002820 catalytic residue [active] 767453002821 dihydrodipicolinate reductase; Provisional; Region: PRK00048 767453002822 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 767453002823 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 767453002824 aromatic amino acid aminotransferase; Validated; Region: PRK07309 767453002825 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767453002826 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767453002827 homodimer interface [polypeptide binding]; other site 767453002828 catalytic residue [active] 767453002829 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 767453002830 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 767453002831 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 767453002832 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 767453002833 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 767453002834 TrkA-N domain; Region: TrkA_N; pfam02254 767453002835 TrkA-C domain; Region: TrkA_C; pfam02080 767453002836 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 767453002837 Family of unknown function (DUF633); Region: DUF633; pfam04816 767453002838 Uncharacterized conserved protein [Function unknown]; Region: COG0327 767453002839 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 767453002840 peptidase T; Region: peptidase-T; TIGR01882 767453002841 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 767453002842 metal binding site [ion binding]; metal-binding site 767453002843 dimer interface [polypeptide binding]; other site 767453002844 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 767453002845 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 767453002846 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 767453002847 active site 767453002848 PHP Thumb interface [polypeptide binding]; other site 767453002849 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 767453002850 generic binding surface I; other site 767453002851 generic binding surface II; other site 767453002852 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 767453002853 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 767453002854 domain interfaces; other site 767453002855 active site 767453002856 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 767453002857 S1 domain; Region: S1_2; pfam13509 767453002858 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767453002859 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 767453002860 active site 767453002861 DNA binding site [nucleotide binding] 767453002862 Int/Topo IB signature motif; other site 767453002863 ScpA/B protein; Region: ScpA_ScpB; cl00598 767453002864 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 767453002865 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 767453002866 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767453002867 RNA binding surface [nucleotide binding]; other site 767453002868 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 767453002869 active site 767453002870 Predicted membrane protein [Function unknown]; Region: COG3601 767453002871 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 767453002872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 767453002873 DEAD-like helicases superfamily; Region: DEXDc; smart00487 767453002874 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767453002875 ATP binding site [chemical binding]; other site 767453002876 putative Mg++ binding site [ion binding]; other site 767453002877 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767453002878 nucleotide binding region [chemical binding]; other site 767453002879 ATP-binding site [chemical binding]; other site 767453002880 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767453002881 cytidylate kinase; Provisional; Region: cmk; PRK00023 767453002882 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 767453002883 CMP-binding site; other site 767453002884 The sites determining sugar specificity; other site 767453002885 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 767453002886 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 767453002887 RNA binding site [nucleotide binding]; other site 767453002888 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 767453002889 RNA binding site [nucleotide binding]; other site 767453002890 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 767453002891 RNA binding site [nucleotide binding]; other site 767453002892 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 767453002893 RNA binding site [nucleotide binding]; other site 767453002894 GTP-binding protein Der; Reviewed; Region: PRK00093 767453002895 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 767453002896 G1 box; other site 767453002897 GTP/Mg2+ binding site [chemical binding]; other site 767453002898 Switch I region; other site 767453002899 G2 box; other site 767453002900 Switch II region; other site 767453002901 G3 box; other site 767453002902 G4 box; other site 767453002903 G5 box; other site 767453002904 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 767453002905 G1 box; other site 767453002906 GTP/Mg2+ binding site [chemical binding]; other site 767453002907 Switch I region; other site 767453002908 G2 box; other site 767453002909 G3 box; other site 767453002910 Switch II region; other site 767453002911 G4 box; other site 767453002912 G5 box; other site 767453002913 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 767453002914 IHF dimer interface [polypeptide binding]; other site 767453002915 IHF - DNA interface [nucleotide binding]; other site 767453002916 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 767453002917 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767453002918 TPR motif; other site 767453002919 binding surface 767453002920 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 767453002921 binding surface 767453002922 TPR motif; other site 767453002923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 767453002924 TPR motif; other site 767453002925 binding surface 767453002926 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767453002927 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 767453002928 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 767453002929 active site 767453002930 NTP binding site [chemical binding]; other site 767453002931 metal binding triad [ion binding]; metal-binding site 767453002932 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 767453002933 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 767453002934 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 767453002935 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767453002936 Walker A/P-loop; other site 767453002937 ATP binding site [chemical binding]; other site 767453002938 Q-loop/lid; other site 767453002939 ABC transporter signature motif; other site 767453002940 Walker B; other site 767453002941 D-loop; other site 767453002942 H-loop/switch region; other site 767453002943 ABC transporter; Region: ABC_tran_2; pfam12848 767453002944 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767453002945 thymidylate synthase; Region: thym_sym; TIGR03284 767453002946 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 767453002947 dimerization interface [polypeptide binding]; other site 767453002948 active site 767453002949 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 767453002950 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 767453002951 folate binding site [chemical binding]; other site 767453002952 NADP+ binding site [chemical binding]; other site 767453002953 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 767453002954 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 767453002955 EDD domain protein, DegV family; Region: DegV; TIGR00762 767453002956 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 767453002957 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 767453002958 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 767453002959 putative ligand binding site [chemical binding]; other site 767453002960 putative NAD binding site [chemical binding]; other site 767453002961 putative catalytic site [active] 767453002962 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 767453002963 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 767453002964 trimer interface [polypeptide binding]; other site 767453002965 active site 767453002966 substrate binding site [chemical binding]; other site 767453002967 CoA binding site [chemical binding]; other site 767453002968 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 767453002969 active site 767453002970 catalytic triad [active] 767453002971 oxyanion hole [active] 767453002972 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 767453002973 hypothetical protein; Provisional; Region: PRK13672 767453002974 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 767453002975 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 767453002976 GTP/Mg2+ binding site [chemical binding]; other site 767453002977 G4 box; other site 767453002978 G5 box; other site 767453002979 G1 box; other site 767453002980 Switch I region; other site 767453002981 G2 box; other site 767453002982 G3 box; other site 767453002983 Switch II region; other site 767453002984 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 767453002985 RNA/DNA hybrid binding site [nucleotide binding]; other site 767453002986 active site 767453002987 DNA protecting protein DprA; Region: dprA; TIGR00732 767453002988 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 767453002989 DNA topoisomerase I; Validated; Region: PRK05582 767453002990 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 767453002991 active site 767453002992 interdomain interaction site; other site 767453002993 putative metal-binding site [ion binding]; other site 767453002994 nucleotide binding site [chemical binding]; other site 767453002995 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 767453002996 domain I; other site 767453002997 DNA binding groove [nucleotide binding] 767453002998 phosphate binding site [ion binding]; other site 767453002999 domain II; other site 767453003000 domain III; other site 767453003001 nucleotide binding site [chemical binding]; other site 767453003002 catalytic site [active] 767453003003 domain IV; other site 767453003004 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 767453003005 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 767453003006 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 767453003007 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767453003008 active site 767453003009 DNA binding site [nucleotide binding] 767453003010 Int/Topo IB signature motif; other site 767453003011 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 767453003012 active site 767453003013 catalytic residues [active] 767453003014 membrane protein; Provisional; Region: PRK14392 767453003015 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 767453003016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767453003017 ATP binding site [chemical binding]; other site 767453003018 Mg2+ binding site [ion binding]; other site 767453003019 G-X-G motif; other site 767453003020 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 767453003021 anchoring element; other site 767453003022 dimer interface [polypeptide binding]; other site 767453003023 ATP binding site [chemical binding]; other site 767453003024 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 767453003025 active site 767453003026 putative metal-binding site [ion binding]; other site 767453003027 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 767453003028 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 767453003029 CAP-like domain; other site 767453003030 DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521 767453003031 active site 767453003032 primary dimer interface [polypeptide binding]; other site 767453003033 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767453003034 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 767453003035 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 767453003036 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 767453003037 DHH family; Region: DHH; pfam01368 767453003038 DHHA2 domain; Region: DHHA2; pfam02833 767453003039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 767453003040 methionine sulfoxide reductase B; Provisional; Region: PRK00222 767453003041 SelR domain; Region: SelR; pfam01641 767453003042 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 767453003043 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767453003044 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767453003045 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767453003046 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453003047 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453003048 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453003049 Probable transposase; Region: OrfB_IS605; pfam01385 767453003050 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453003051 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767453003052 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 767453003053 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767453003054 Coenzyme A binding pocket [chemical binding]; other site 767453003055 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 767453003056 GAF domain; Region: GAF_2; pfam13185 767453003057 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 767453003058 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 767453003059 Na binding site [ion binding]; other site 767453003060 cytosine deaminase; Provisional; Region: PRK09230 767453003061 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 767453003062 active site 767453003063 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 767453003064 active site 767453003065 metal-binding site [ion binding] 767453003066 nucleotide-binding site [chemical binding]; other site 767453003067 recombination factor protein RarA; Reviewed; Region: PRK13342 767453003068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767453003069 Walker A motif; other site 767453003070 ATP binding site [chemical binding]; other site 767453003071 Walker B motif; other site 767453003072 arginine finger; other site 767453003073 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 767453003074 Protein of unknown function (DUF554); Region: DUF554; pfam04474 767453003075 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 767453003076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 767453003077 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 767453003078 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 767453003079 dimer interface [polypeptide binding]; other site 767453003080 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 767453003081 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 767453003082 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 767453003083 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 767453003084 hypothetical protein; Provisional; Region: PRK07475 767453003085 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 767453003086 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 767453003087 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 767453003088 homodimer interface [polypeptide binding]; other site 767453003089 substrate-cofactor binding pocket; other site 767453003090 catalytic residue [active] 767453003091 maltose O-acetyltransferase; Provisional; Region: PRK10092 767453003092 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 767453003093 active site 767453003094 substrate binding site [chemical binding]; other site 767453003095 trimer interface [polypeptide binding]; other site 767453003096 CoA binding site [chemical binding]; other site 767453003097 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 767453003098 trimer interface [polypeptide binding]; other site 767453003099 active site 767453003100 substrate binding site [chemical binding]; other site 767453003101 Fic/DOC family; Region: Fic; pfam02661 767453003102 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767453003103 active site 767453003104 benzoate transport; Region: 2A0115; TIGR00895 767453003105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453003106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453003107 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 767453003108 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 767453003109 transaminase; Validated; Region: PRK07324 767453003110 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767453003111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767453003112 homodimer interface [polypeptide binding]; other site 767453003113 catalytic residue [active] 767453003114 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 767453003115 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 767453003116 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 767453003117 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 767453003118 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767453003119 Coenzyme A binding pocket [chemical binding]; other site 767453003120 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 767453003121 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 767453003122 putative active site [active] 767453003123 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 767453003124 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 767453003125 active site 767453003126 catalytic tetrad [active] 767453003127 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 767453003128 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 767453003129 substrate binding site [chemical binding]; other site 767453003130 ATP binding site [chemical binding]; other site 767453003131 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 767453003132 isocitrate dehydrogenase; Validated; Region: PRK07362 767453003133 Membrane transport protein; Region: Mem_trans; cl09117 767453003134 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 767453003135 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767453003136 active site 767453003137 DNA binding site [nucleotide binding] 767453003138 Int/Topo IB signature motif; other site 767453003139 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 767453003140 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 767453003141 active site 767453003142 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 767453003143 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767453003144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767453003145 homodimer interface [polypeptide binding]; other site 767453003146 catalytic residue [active] 767453003147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453003148 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453003149 Probable transposase; Region: OrfB_IS605; pfam01385 767453003150 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453003151 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453003152 Transposase IS200 like; Region: Y1_Tnp; cl00848 767453003153 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767453003154 MULE transposase domain; Region: MULE; pfam10551 767453003155 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 767453003156 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 767453003157 putative NAD(P) binding site [chemical binding]; other site 767453003158 catalytic Zn binding site [ion binding]; other site 767453003159 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 767453003160 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 767453003161 putative NAD(P) binding site [chemical binding]; other site 767453003162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767453003163 ABC-ATPase subunit interface; other site 767453003164 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 767453003165 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767453003166 Walker A/P-loop; other site 767453003167 ATP binding site [chemical binding]; other site 767453003168 Q-loop/lid; other site 767453003169 ABC transporter signature motif; other site 767453003170 Walker B; other site 767453003171 D-loop; other site 767453003172 H-loop/switch region; other site 767453003173 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 767453003174 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 767453003175 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 767453003176 Predicted transcriptional regulator [Transcription]; Region: COG1959 767453003177 Transcriptional regulator; Region: Rrf2; pfam02082 767453003178 OsmC-like protein; Region: OsmC; pfam02566 767453003179 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767453003180 Coenzyme A binding pocket [chemical binding]; other site 767453003181 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453003182 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767453003183 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453003184 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453003185 Probable transposase; Region: OrfB_IS605; pfam01385 767453003186 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453003187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767453003188 NADH(P)-binding; Region: NAD_binding_10; pfam13460 767453003189 NAD(P) binding site [chemical binding]; other site 767453003190 active site 767453003191 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767453003192 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767453003193 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767453003194 DNA binding site [nucleotide binding] 767453003195 active site 767453003196 Int/Topo IB signature motif; other site 767453003197 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 767453003198 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 767453003199 Lipase (class 2); Region: Lipase_2; pfam01674 767453003200 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 767453003201 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 767453003202 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 767453003203 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 767453003204 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 767453003205 citrate lyase subunit gamma; Provisional; Region: PRK13253 767453003206 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 767453003207 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767453003208 active site 767453003209 nucleotide binding site [chemical binding]; other site 767453003210 HIGH motif; other site 767453003211 KMSKS motif; other site 767453003212 Membrane transport protein; Region: Mem_trans; cl09117 767453003213 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 767453003214 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 767453003215 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 767453003216 catalytic Zn binding site [ion binding]; other site 767453003217 NAD binding site [chemical binding]; other site 767453003218 structural Zn binding site [ion binding]; other site 767453003219 Helix-turn-helix domain; Region: HTH_38; pfam13936 767453003220 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 767453003221 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 767453003222 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 767453003223 substrate binding site [chemical binding]; other site 767453003224 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 767453003225 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 767453003226 substrate binding site [chemical binding]; other site 767453003227 ligand binding site [chemical binding]; other site 767453003228 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 767453003229 tartrate dehydrogenase; Region: TTC; TIGR02089 767453003230 benzoate transport; Region: 2A0115; TIGR00895 767453003231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453003232 putative substrate translocation pore; other site 767453003233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453003234 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 767453003235 Sodium Bile acid symporter family; Region: SBF; pfam01758 767453003236 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 767453003237 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 767453003238 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453003239 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453003240 Helix-turn-helix domain; Region: HTH_38; pfam13936 767453003241 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453003242 Integrase core domain; Region: rve; pfam00665 767453003243 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 767453003244 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 767453003245 Lipase (class 2); Region: Lipase_2; pfam01674 767453003246 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 767453003247 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 767453003248 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 767453003249 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 767453003250 CoenzymeA binding site [chemical binding]; other site 767453003251 subunit interaction site [polypeptide binding]; other site 767453003252 PHB binding site; other site 767453003253 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 767453003254 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 767453003255 substrate binding site [chemical binding]; other site 767453003256 oxyanion hole (OAH) forming residues; other site 767453003257 trimer interface [polypeptide binding]; other site 767453003258 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 767453003259 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 767453003260 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 767453003261 acyl-activating enzyme (AAE) consensus motif; other site 767453003262 putative AMP binding site [chemical binding]; other site 767453003263 putative active site [active] 767453003264 putative CoA binding site [chemical binding]; other site 767453003265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453003266 D-galactonate transporter; Region: 2A0114; TIGR00893 767453003267 putative substrate translocation pore; other site 767453003268 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 767453003269 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 767453003270 tetramer interface [polypeptide binding]; other site 767453003271 catalytic Zn binding site [ion binding]; other site 767453003272 NADP binding site [chemical binding]; other site 767453003273 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453003274 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453003275 Probable transposase; Region: OrfB_IS605; pfam01385 767453003276 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453003277 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453003278 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 767453003279 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 767453003280 homodimer interface [polypeptide binding]; other site 767453003281 substrate-cofactor binding pocket; other site 767453003282 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767453003283 catalytic residue [active] 767453003284 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 767453003285 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 767453003286 dimer interface [polypeptide binding]; other site 767453003287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767453003288 catalytic residue [active] 767453003289 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 767453003290 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 767453003291 Predicted transcriptional regulator [Transcription]; Region: COG2378 767453003292 HTH domain; Region: HTH_11; pfam08279 767453003293 WYL domain; Region: WYL; pfam13280 767453003294 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 767453003295 EamA-like transporter family; Region: EamA; pfam00892 767453003296 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 767453003297 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 767453003298 FAD binding domain; Region: FAD_binding_2; pfam00890 767453003299 L-aspartate oxidase; Provisional; Region: PRK06175 767453003300 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 767453003301 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767453003302 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767453003303 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767453003304 dimerization interface [polypeptide binding]; other site 767453003305 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 767453003306 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 767453003307 active site 767453003308 nucleophile elbow; other site 767453003309 putative acyltransferase; Provisional; Region: PRK05790 767453003310 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 767453003311 dimer interface [polypeptide binding]; other site 767453003312 active site 767453003313 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 767453003314 Domain of unknown function DUF20; Region: UPF0118; pfam01594 767453003315 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 767453003316 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 767453003317 tetramer interfaces [polypeptide binding]; other site 767453003318 binuclear metal-binding site [ion binding]; other site 767453003319 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 767453003320 Beta-lactamase; Region: Beta-lactamase; pfam00144 767453003321 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 767453003322 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 767453003323 putative active site [active] 767453003324 catalytic site [active] 767453003325 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 767453003326 Walker A motif; other site 767453003327 ATP binding site [chemical binding]; other site 767453003328 Walker B motif; other site 767453003329 arginine finger; other site 767453003330 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 767453003331 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 767453003332 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 767453003333 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 767453003334 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 767453003335 Peptidase family C69; Region: Peptidase_C69; pfam03577 767453003336 TPR repeat; Region: TPR_11; pfam13414 767453003337 putative transport protein YifK; Provisional; Region: PRK10746 767453003338 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 767453003339 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 767453003340 TPP-binding site; other site 767453003341 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 767453003342 PYR/PP interface [polypeptide binding]; other site 767453003343 dimer interface [polypeptide binding]; other site 767453003344 TPP binding site [chemical binding]; other site 767453003345 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 767453003346 AAA ATPase domain; Region: AAA_16; pfam13191 767453003347 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 767453003348 Uncharacterized conserved protein [Function unknown]; Region: COG3410 767453003349 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 767453003350 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 767453003351 active site 767453003352 multimer interface [polypeptide binding]; other site 767453003353 Predicted transcriptional regulators [Transcription]; Region: COG1695 767453003354 Transcriptional regulator PadR-like family; Region: PadR; cl17335 767453003355 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 767453003356 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 767453003357 Acyltransferase family; Region: Acyl_transf_3; pfam01757 767453003358 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767453003359 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767453003360 substrate binding pocket [chemical binding]; other site 767453003361 membrane-bound complex binding site; other site 767453003362 hinge residues; other site 767453003363 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 767453003364 aspartate aminotransferase; Provisional; Region: PRK05764 767453003365 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767453003366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767453003367 homodimer interface [polypeptide binding]; other site 767453003368 catalytic residue [active] 767453003369 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 767453003370 L-tyrosine decarboxylase; Provisional; Region: PRK13520 767453003371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767453003372 catalytic residue [active] 767453003373 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 767453003374 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 767453003375 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767453003376 sequence-specific DNA binding site [nucleotide binding]; other site 767453003377 salt bridge; other site 767453003378 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 767453003379 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 767453003380 NAD(P) binding site [chemical binding]; other site 767453003381 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 767453003382 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 767453003383 guanine deaminase; Region: guan_deamin; TIGR02967 767453003384 active site 767453003385 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 767453003386 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 767453003387 metal binding site [ion binding]; metal-binding site 767453003388 dimer interface [polypeptide binding]; other site 767453003389 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 767453003390 Low molecular weight phosphatase family; Region: LMWPc; cd00115 767453003391 active site 767453003392 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 767453003393 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 767453003394 active site 767453003395 catalytic site [active] 767453003396 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 767453003397 phosphate binding site [ion binding]; other site 767453003398 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 767453003399 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 767453003400 DNA binding residues [nucleotide binding] 767453003401 putative dimer interface [polypeptide binding]; other site 767453003402 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 767453003403 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 767453003404 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767453003405 Walker A/P-loop; other site 767453003406 ATP binding site [chemical binding]; other site 767453003407 Q-loop/lid; other site 767453003408 ABC transporter signature motif; other site 767453003409 Walker B; other site 767453003410 D-loop; other site 767453003411 H-loop/switch region; other site 767453003412 acetolactate synthase; Reviewed; Region: PRK08617 767453003413 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 767453003414 PYR/PP interface [polypeptide binding]; other site 767453003415 dimer interface [polypeptide binding]; other site 767453003416 TPP binding site [chemical binding]; other site 767453003417 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 767453003418 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 767453003419 TPP-binding site [chemical binding]; other site 767453003420 dimer interface [polypeptide binding]; other site 767453003421 T5orf172 domain; Region: T5orf172; pfam10544 767453003422 DEAD-like helicases superfamily; Region: DEXDc; smart00487 767453003423 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767453003424 ATP binding site [chemical binding]; other site 767453003425 putative Mg++ binding site [ion binding]; other site 767453003426 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 767453003427 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 767453003428 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 767453003429 DNA binding residues [nucleotide binding] 767453003430 Helix-turn-helix domain; Region: HTH_28; pfam13518 767453003431 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767453003432 MULE transposase domain; Region: MULE; pfam10551 767453003433 HTH-like domain; Region: HTH_21; pfam13276 767453003434 Integrase core domain; Region: rve; pfam00665 767453003435 Integrase core domain; Region: rve; pfam00665 767453003436 Integrase core domain; Region: rve_3; pfam13683 767453003437 MucBP domain; Region: MucBP; pfam06458 767453003438 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 767453003439 DDE domain; Region: DDE_Tnp_IS240; pfam13610 767453003440 Integrase core domain; Region: rve; pfam00665 767453003441 Integrase core domain; Region: rve_3; pfam13683 767453003442 CrcB-like protein; Region: CRCB; pfam02537 767453003443 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 767453003444 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 767453003445 dimer interface [polypeptide binding]; other site 767453003446 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 767453003447 metal binding site [ion binding]; metal-binding site 767453003448 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767453003449 Coenzyme A binding pocket [chemical binding]; other site 767453003450 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 767453003451 ABC1 family; Region: ABC1; cl17513 767453003452 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 767453003453 FAD binding pocket [chemical binding]; other site 767453003454 conserved FAD binding motif [chemical binding]; other site 767453003455 phosphate binding motif [ion binding]; other site 767453003456 beta-alpha-beta structure motif; other site 767453003457 NAD binding pocket [chemical binding]; other site 767453003458 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 767453003459 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 767453003460 nucleotide binding site [chemical binding]; other site 767453003461 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 767453003462 Penicillinase repressor; Region: Pencillinase_R; pfam03965 767453003463 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 767453003464 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767453003465 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 767453003466 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 767453003467 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 767453003468 N- and C-terminal domain interface [polypeptide binding]; other site 767453003469 active site 767453003470 catalytic site [active] 767453003471 metal binding site [ion binding]; metal-binding site 767453003472 carbohydrate binding site [chemical binding]; other site 767453003473 ATP binding site [chemical binding]; other site 767453003474 GntP family permease; Region: GntP_permease; pfam02447 767453003475 fructuronate transporter; Provisional; Region: PRK10034; cl15264 767453003476 Transcriptional regulators [Transcription]; Region: PurR; COG1609 767453003477 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767453003478 domain linker motif; other site 767453003479 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 767453003480 putative dimerization interface [polypeptide binding]; other site 767453003481 putative ligand binding site [chemical binding]; other site 767453003482 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 767453003483 aspartate aminotransferase; Provisional; Region: PRK05764 767453003484 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767453003485 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767453003486 homodimer interface [polypeptide binding]; other site 767453003487 catalytic residue [active] 767453003488 VanZ like family; Region: VanZ; pfam04892 767453003489 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453003490 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453003491 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453003492 Probable transposase; Region: OrfB_IS605; pfam01385 767453003493 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453003494 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 767453003495 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 767453003496 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 767453003497 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 767453003498 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 767453003499 [4Fe-4S] binding site [ion binding]; other site 767453003500 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 767453003501 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 767453003502 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 767453003503 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 767453003504 molybdopterin cofactor binding site; other site 767453003505 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 767453003506 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 767453003507 ATP binding site [chemical binding]; other site 767453003508 substrate interface [chemical binding]; other site 767453003509 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 767453003510 MPT binding site; other site 767453003511 trimer interface [polypeptide binding]; other site 767453003512 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 767453003513 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 767453003514 dimer interface [polypeptide binding]; other site 767453003515 putative functional site; other site 767453003516 putative MPT binding site; other site 767453003517 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 767453003518 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 767453003519 trimer interface [polypeptide binding]; other site 767453003520 dimer interface [polypeptide binding]; other site 767453003521 putative active site [active] 767453003522 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 767453003523 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 767453003524 GTP binding site; other site 767453003525 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 767453003526 Histidine kinase; Region: HisKA_3; pfam07730 767453003527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767453003528 ATP binding site [chemical binding]; other site 767453003529 Mg2+ binding site [ion binding]; other site 767453003530 G-X-G motif; other site 767453003531 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 767453003532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767453003533 active site 767453003534 phosphorylation site [posttranslational modification] 767453003535 intermolecular recognition site; other site 767453003536 dimerization interface [polypeptide binding]; other site 767453003537 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 767453003538 DNA binding residues [nucleotide binding] 767453003539 dimerization interface [polypeptide binding]; other site 767453003540 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 767453003541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767453003542 S-adenosylmethionine binding site [chemical binding]; other site 767453003543 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767453003544 non-specific DNA binding site [nucleotide binding]; other site 767453003545 salt bridge; other site 767453003546 sequence-specific DNA binding site [nucleotide binding]; other site 767453003547 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 767453003548 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 767453003549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453003550 putative substrate translocation pore; other site 767453003551 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 767453003552 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 767453003553 FeS/SAM binding site; other site 767453003554 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 767453003555 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 767453003556 MoaE interaction surface [polypeptide binding]; other site 767453003557 MoeB interaction surface [polypeptide binding]; other site 767453003558 thiocarboxylated glycine; other site 767453003559 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 767453003560 MoaE homodimer interface [polypeptide binding]; other site 767453003561 MoaD interaction [polypeptide binding]; other site 767453003562 active site residues [active] 767453003563 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 767453003564 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 767453003565 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 767453003566 ABC-ATPase subunit interface; other site 767453003567 dimer interface [polypeptide binding]; other site 767453003568 putative PBP binding regions; other site 767453003569 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 767453003570 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 767453003571 Walker A/P-loop; other site 767453003572 ATP binding site [chemical binding]; other site 767453003573 Q-loop/lid; other site 767453003574 ABC transporter signature motif; other site 767453003575 Walker B; other site 767453003576 D-loop; other site 767453003577 H-loop/switch region; other site 767453003578 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 767453003579 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767453003580 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 767453003581 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 767453003582 Uncharacterized conserved protein [Function unknown]; Region: COG2461 767453003583 Family of unknown function (DUF438); Region: DUF438; pfam04282 767453003584 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 767453003585 EamA-like transporter family; Region: EamA; pfam00892 767453003586 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 767453003587 putative ligand binding residues [chemical binding]; other site 767453003588 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 767453003589 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 767453003590 FeS assembly protein SufB; Region: sufB; TIGR01980 767453003591 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 767453003592 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 767453003593 trimerization site [polypeptide binding]; other site 767453003594 active site 767453003595 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 767453003596 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 767453003597 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 767453003598 catalytic residue [active] 767453003599 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 767453003600 FeS assembly protein SufD; Region: sufD; TIGR01981 767453003601 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 767453003602 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 767453003603 Walker A/P-loop; other site 767453003604 ATP binding site [chemical binding]; other site 767453003605 Q-loop/lid; other site 767453003606 ABC transporter signature motif; other site 767453003607 Walker B; other site 767453003608 D-loop; other site 767453003609 H-loop/switch region; other site 767453003610 FeoA domain; Region: FeoA; pfam04023 767453003611 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 767453003612 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 767453003613 G1 box; other site 767453003614 GTP/Mg2+ binding site [chemical binding]; other site 767453003615 Switch I region; other site 767453003616 G2 box; other site 767453003617 G3 box; other site 767453003618 Switch II region; other site 767453003619 G4 box; other site 767453003620 G5 box; other site 767453003621 Nucleoside recognition; Region: Gate; pfam07670 767453003622 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 767453003623 Nucleoside recognition; Region: Gate; pfam07670 767453003624 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 767453003625 UbiA prenyltransferase family; Region: UbiA; pfam01040 767453003626 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 767453003627 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 767453003628 substrate binding pocket [chemical binding]; other site 767453003629 chain length determination region; other site 767453003630 substrate-Mg2+ binding site; other site 767453003631 catalytic residues [active] 767453003632 aspartate-rich region 1; other site 767453003633 active site lid residues [active] 767453003634 aspartate-rich region 2; other site 767453003635 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 767453003636 D-lactate dehydrogenase; Validated; Region: PRK08605 767453003637 homodimer interface [polypeptide binding]; other site 767453003638 ligand binding site [chemical binding]; other site 767453003639 NAD binding site [chemical binding]; other site 767453003640 catalytic site [active] 767453003641 aspartate aminotransferase; Provisional; Region: PRK06348 767453003642 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 767453003643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767453003644 homodimer interface [polypeptide binding]; other site 767453003645 catalytic residue [active] 767453003646 shikimate kinase; Reviewed; Region: aroK; PRK00131 767453003647 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 767453003648 ADP binding site [chemical binding]; other site 767453003649 magnesium binding site [ion binding]; other site 767453003650 putative shikimate binding site; other site 767453003651 prephenate dehydrogenase; Validated; Region: PRK06545 767453003652 prephenate dehydrogenase; Validated; Region: PRK08507 767453003653 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 767453003654 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 767453003655 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 767453003656 hinge; other site 767453003657 active site 767453003658 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 767453003659 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 767453003660 Tetramer interface [polypeptide binding]; other site 767453003661 active site 767453003662 FMN-binding site [chemical binding]; other site 767453003663 hypothetical protein; Provisional; Region: PRK07248 767453003664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453003665 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767453003666 putative substrate translocation pore; other site 767453003667 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 767453003668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453003669 POT family; Region: PTR2; cl17359 767453003670 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 767453003671 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 767453003672 active site 767453003673 motif I; other site 767453003674 motif II; other site 767453003675 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 767453003676 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 767453003677 NADP binding site [chemical binding]; other site 767453003678 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 767453003679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453003680 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767453003681 putative substrate translocation pore; other site 767453003682 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 767453003683 Probable transposase; Region: OrfB_IS605; pfam01385 767453003684 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453003685 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767453003686 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453003687 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453003688 K+ potassium transporter; Region: K_trans; pfam02705 767453003689 glycerol kinase; Provisional; Region: glpK; PRK00047 767453003690 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 767453003691 N- and C-terminal domain interface [polypeptide binding]; other site 767453003692 active site 767453003693 MgATP binding site [chemical binding]; other site 767453003694 catalytic site [active] 767453003695 metal binding site [ion binding]; metal-binding site 767453003696 glycerol binding site [chemical binding]; other site 767453003697 homotetramer interface [polypeptide binding]; other site 767453003698 homodimer interface [polypeptide binding]; other site 767453003699 FBP binding site [chemical binding]; other site 767453003700 protein IIAGlc interface [polypeptide binding]; other site 767453003701 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 767453003702 active site 1 [active] 767453003703 dimer interface [polypeptide binding]; other site 767453003704 hexamer interface [polypeptide binding]; other site 767453003705 active site 2 [active] 767453003706 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 767453003707 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 767453003708 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 767453003709 TrkA-N domain; Region: TrkA_N; pfam02254 767453003710 TrkA-C domain; Region: TrkA_C; pfam02080 767453003711 Peptidase family C69; Region: Peptidase_C69; pfam03577 767453003712 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 767453003713 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 767453003714 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 767453003715 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 767453003716 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 767453003717 active site 767453003718 metal binding site [ion binding]; metal-binding site 767453003719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453003720 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767453003721 putative substrate translocation pore; other site 767453003722 drug efflux system protein MdtG; Provisional; Region: PRK09874 767453003723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453003724 putative substrate translocation pore; other site 767453003725 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 767453003726 Domain of unknown function DUF21; Region: DUF21; pfam01595 767453003727 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 767453003728 Transporter associated domain; Region: CorC_HlyC; pfam03471 767453003729 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767453003730 Helix-turn-helix domain; Region: HTH_28; pfam13518 767453003731 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 767453003732 HTH-like domain; Region: HTH_21; pfam13276 767453003733 Integrase core domain; Region: rve; pfam00665 767453003734 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767453003735 sequence-specific DNA binding site [nucleotide binding]; other site 767453003736 salt bridge; other site 767453003737 Domain of unknown function (DUF955); Region: DUF955; cl01076 767453003738 Ion channel; Region: Ion_trans_2; pfam07885 767453003739 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 767453003740 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 767453003741 Int/Topo IB signature motif; other site 767453003742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453003743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 767453003744 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 767453003745 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767453003746 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767453003747 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767453003748 dimerization interface [polypeptide binding]; other site 767453003749 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 767453003750 active site 767453003751 oxyanion hole [active] 767453003752 catalytic triad [active] 767453003753 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 767453003754 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 767453003755 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 767453003756 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 767453003757 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767453003758 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767453003759 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 767453003760 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 767453003761 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 767453003762 E3 interaction surface; other site 767453003763 lipoyl attachment site [posttranslational modification]; other site 767453003764 e3 binding domain; Region: E3_binding; pfam02817 767453003765 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 767453003766 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 767453003767 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 767453003768 alpha subunit interface [polypeptide binding]; other site 767453003769 TPP binding site [chemical binding]; other site 767453003770 heterodimer interface [polypeptide binding]; other site 767453003771 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 767453003772 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 767453003773 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 767453003774 tetramer interface [polypeptide binding]; other site 767453003775 TPP-binding site [chemical binding]; other site 767453003776 heterodimer interface [polypeptide binding]; other site 767453003777 phosphorylation loop region [posttranslational modification] 767453003778 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 767453003779 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 767453003780 AzlC protein; Region: AzlC; cl00570 767453003781 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 767453003782 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 767453003783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767453003784 catalytic residue [active] 767453003785 homoserine dehydrogenase; Provisional; Region: PRK06349 767453003786 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 767453003787 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 767453003788 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 767453003789 homoserine kinase; Provisional; Region: PRK01212 767453003790 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 767453003791 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 767453003792 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 767453003793 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767453003794 Coenzyme A binding pocket [chemical binding]; other site 767453003795 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 767453003796 NADH(P)-binding; Region: NAD_binding_10; pfam13460 767453003797 NAD(P) binding site [chemical binding]; other site 767453003798 putative active site [active] 767453003799 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 767453003800 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 767453003801 Protein of unknown function (DUF328); Region: DUF328; pfam03883 767453003802 EDD domain protein, DegV family; Region: DegV; TIGR00762 767453003803 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 767453003804 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 767453003805 Domain of unknown function (DUF814); Region: DUF814; pfam05670 767453003806 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767453003807 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767453003808 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767453003809 MULE transposase domain; Region: MULE; pfam10551 767453003810 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 767453003811 arsenical-resistance protein; Region: acr3; TIGR00832 767453003812 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453003813 Integrase core domain; Region: rve; pfam00665 767453003814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767453003815 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767453003816 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767453003817 LysR substrate binding domain; Region: LysR_substrate; pfam03466 767453003818 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 767453003819 active site 767453003820 zinc binding site [ion binding]; other site 767453003821 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 767453003822 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767453003823 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 767453003824 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 767453003825 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 767453003826 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 767453003827 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 767453003828 catalytic site [active] 767453003829 subunit interface [polypeptide binding]; other site 767453003830 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 767453003831 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767453003832 RNA binding surface [nucleotide binding]; other site 767453003833 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 767453003834 active site 767453003835 lipoprotein signal peptidase; Provisional; Region: PRK14797 767453003836 lipoprotein signal peptidase; Provisional; Region: PRK14787 767453003837 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 767453003838 RNA/DNA hybrid binding site [nucleotide binding]; other site 767453003839 active site 767453003840 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 767453003841 dimer interface [polypeptide binding]; other site 767453003842 FMN binding site [chemical binding]; other site 767453003843 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767453003844 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767453003845 substrate binding pocket [chemical binding]; other site 767453003846 membrane-bound complex binding site; other site 767453003847 hinge residues; other site 767453003848 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 767453003849 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 767453003850 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 767453003851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 767453003852 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 767453003853 nudix motif; other site 767453003854 AAA-like domain; Region: AAA_10; pfam12846 767453003855 Zonular occludens toxin (Zot); Region: Zot; cl17485 767453003856 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 767453003857 elongation factor G; Reviewed; Region: PRK12740 767453003858 G1 box; other site 767453003859 putative GEF interaction site [polypeptide binding]; other site 767453003860 GTP/Mg2+ binding site [chemical binding]; other site 767453003861 Switch I region; other site 767453003862 G2 box; other site 767453003863 G3 box; other site 767453003864 Switch II region; other site 767453003865 G4 box; other site 767453003866 G5 box; other site 767453003867 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 767453003868 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 767453003869 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 767453003870 cell division protein GpsB; Provisional; Region: PRK14127 767453003871 hypothetical protein; Provisional; Region: PRK13660 767453003872 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 767453003873 Transglycosylase; Region: Transgly; pfam00912 767453003874 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 767453003875 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 767453003876 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 767453003877 EamA-like transporter family; Region: EamA; pfam00892 767453003878 EamA-like transporter family; Region: EamA; pfam00892 767453003879 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 767453003880 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 767453003881 active site 767453003882 catalytic tetrad [active] 767453003883 Predicted secreted protein [Function unknown]; Region: COG4086 767453003884 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 767453003885 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 767453003886 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 767453003887 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 767453003888 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 767453003889 putative dimer interface [polypeptide binding]; other site 767453003890 putative anticodon binding site; other site 767453003891 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 767453003892 homodimer interface [polypeptide binding]; other site 767453003893 motif 1; other site 767453003894 motif 2; other site 767453003895 active site 767453003896 motif 3; other site 767453003897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 767453003898 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 767453003899 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 767453003900 active site 767453003901 catalytic site [active] 767453003902 substrate binding site [chemical binding]; other site 767453003903 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 767453003904 mevalonate kinase; Region: mevalon_kin; TIGR00549 767453003905 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 767453003906 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 767453003907 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 767453003908 diphosphomevalonate decarboxylase; Region: PLN02407 767453003909 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 767453003910 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 767453003911 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 767453003912 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 767453003913 homotetramer interface [polypeptide binding]; other site 767453003914 FMN binding site [chemical binding]; other site 767453003915 homodimer contacts [polypeptide binding]; other site 767453003916 putative active site [active] 767453003917 putative substrate binding site [chemical binding]; other site 767453003918 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 767453003919 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 767453003920 Walker A/P-loop; other site 767453003921 ATP binding site [chemical binding]; other site 767453003922 Q-loop/lid; other site 767453003923 ABC transporter signature motif; other site 767453003924 Walker B; other site 767453003925 D-loop; other site 767453003926 H-loop/switch region; other site 767453003927 Probable transposase; Region: OrfB_IS605; pfam01385 767453003928 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453003929 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767453003930 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453003931 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453003932 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 767453003933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767453003934 S-adenosylmethionine binding site [chemical binding]; other site 767453003935 Uncharacterized conserved protein [Function unknown]; Region: COG3270 767453003936 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 767453003937 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767453003938 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 767453003939 active site 767453003940 motif I; other site 767453003941 motif II; other site 767453003942 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 767453003943 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 767453003944 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 767453003945 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 767453003946 heterodimer interface [polypeptide binding]; other site 767453003947 active site 767453003948 FMN binding site [chemical binding]; other site 767453003949 homodimer interface [polypeptide binding]; other site 767453003950 substrate binding site [chemical binding]; other site 767453003951 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 767453003952 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767453003953 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 767453003954 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 767453003955 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767453003956 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767453003957 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 767453003958 IMP binding site; other site 767453003959 dimer interface [polypeptide binding]; other site 767453003960 interdomain contacts; other site 767453003961 partial ornithine binding site; other site 767453003962 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 767453003963 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 767453003964 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 767453003965 catalytic site [active] 767453003966 subunit interface [polypeptide binding]; other site 767453003967 dihydroorotase; Validated; Region: pyrC; PRK09357 767453003968 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 767453003969 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 767453003970 active site 767453003971 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 767453003972 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 767453003973 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 767453003974 Protein of unknown function (DUF1445); Region: DUF1445; cl01790 767453003975 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453003976 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453003977 Probable transposase; Region: OrfB_IS605; pfam01385 767453003978 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453003979 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453003980 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767453003981 MULE transposase domain; Region: MULE; pfam10551 767453003982 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 767453003983 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 767453003984 active site 767453003985 catalytic site [active] 767453003986 substrate binding site [chemical binding]; other site 767453003987 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 767453003988 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 767453003989 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 767453003990 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 767453003991 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 767453003992 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 767453003993 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 767453003994 helicase Cas3; Provisional; Region: PRK09694 767453003995 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 767453003996 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 767453003997 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 767453003998 amino acid transporter; Region: 2A0306; TIGR00909 767453003999 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 767453004000 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 767453004001 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 767453004002 RimM N-terminal domain; Region: RimM; pfam01782 767453004003 PRC-barrel domain; Region: PRC; pfam05239 767453004004 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 767453004005 KH domain; Region: KH_4; pfam13083 767453004006 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 767453004007 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 767453004008 PhoU domain; Region: PhoU; pfam01895 767453004009 PhoU domain; Region: PhoU; pfam01895 767453004010 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 767453004011 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 767453004012 Walker A/P-loop; other site 767453004013 ATP binding site [chemical binding]; other site 767453004014 Q-loop/lid; other site 767453004015 ABC transporter signature motif; other site 767453004016 Walker B; other site 767453004017 D-loop; other site 767453004018 H-loop/switch region; other site 767453004019 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 767453004020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767453004021 dimer interface [polypeptide binding]; other site 767453004022 conserved gate region; other site 767453004023 putative PBP binding loops; other site 767453004024 ABC-ATPase subunit interface; other site 767453004025 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 767453004026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767453004027 dimer interface [polypeptide binding]; other site 767453004028 conserved gate region; other site 767453004029 putative PBP binding loops; other site 767453004030 ABC-ATPase subunit interface; other site 767453004031 PBP superfamily domain; Region: PBP_like_2; cl17296 767453004032 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 767453004033 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767453004034 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767453004035 DNA binding site [nucleotide binding] 767453004036 signal recognition particle protein; Provisional; Region: PRK10867 767453004037 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 767453004038 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 767453004039 P loop; other site 767453004040 GTP binding site [chemical binding]; other site 767453004041 Signal peptide binding domain; Region: SRP_SPB; pfam02978 767453004042 putative DNA-binding protein; Validated; Region: PRK00118 767453004043 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 767453004044 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 767453004045 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 767453004046 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 767453004047 P loop; other site 767453004048 GTP binding site [chemical binding]; other site 767453004049 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 767453004050 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 767453004051 Walker A/P-loop; other site 767453004052 ATP binding site [chemical binding]; other site 767453004053 Q-loop/lid; other site 767453004054 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 767453004055 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 767453004056 ABC transporter signature motif; other site 767453004057 Walker B; other site 767453004058 D-loop; other site 767453004059 H-loop/switch region; other site 767453004060 ribonuclease III; Reviewed; Region: rnc; PRK00102 767453004061 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 767453004062 dimerization interface [polypeptide binding]; other site 767453004063 active site 767453004064 metal binding site [ion binding]; metal-binding site 767453004065 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 767453004066 dsRNA binding site [nucleotide binding]; other site 767453004067 acyl carrier protein; Provisional; Region: acpP; PRK00982 767453004068 putative phosphate acyltransferase; Provisional; Region: PRK05331 767453004069 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 767453004070 Y-family of DNA polymerases; Region: PolY; cl12025 767453004071 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767453004072 ATP binding site [chemical binding]; other site 767453004073 putative Mg++ binding site [ion binding]; other site 767453004074 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767453004075 nucleotide binding region [chemical binding]; other site 767453004076 ATP-binding site [chemical binding]; other site 767453004077 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 767453004078 DAK2 domain; Region: Dak2; pfam02734 767453004079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 767453004080 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 767453004081 Thiamine pyrophosphokinase; Region: TPK; cd07995 767453004082 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 767453004083 active site 767453004084 dimerization interface [polypeptide binding]; other site 767453004085 thiamine binding site [chemical binding]; other site 767453004086 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 767453004087 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 767453004088 substrate binding site [chemical binding]; other site 767453004089 hexamer interface [polypeptide binding]; other site 767453004090 metal binding site [ion binding]; metal-binding site 767453004091 GTPase RsgA; Reviewed; Region: PRK00098 767453004092 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 767453004093 RNA binding site [nucleotide binding]; other site 767453004094 homodimer interface [polypeptide binding]; other site 767453004095 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 767453004096 GTPase/Zn-binding domain interface [polypeptide binding]; other site 767453004097 GTP/Mg2+ binding site [chemical binding]; other site 767453004098 G4 box; other site 767453004099 G5 box; other site 767453004100 G1 box; other site 767453004101 Switch I region; other site 767453004102 G2 box; other site 767453004103 G3 box; other site 767453004104 Switch II region; other site 767453004105 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 767453004106 Catalytic domain of Protein Kinases; Region: PKc; cd00180 767453004107 active site 767453004108 ATP binding site [chemical binding]; other site 767453004109 substrate binding site [chemical binding]; other site 767453004110 activation loop (A-loop); other site 767453004111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 767453004112 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 767453004113 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 767453004114 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 767453004115 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 767453004116 active site 767453004117 16S rRNA methyltransferase B; Provisional; Region: PRK14902 767453004118 NusB family; Region: NusB; pfam01029 767453004119 putative RNA binding site [nucleotide binding]; other site 767453004120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767453004121 S-adenosylmethionine binding site [chemical binding]; other site 767453004122 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 767453004123 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 767453004124 putative active site [active] 767453004125 substrate binding site [chemical binding]; other site 767453004126 putative cosubstrate binding site; other site 767453004127 catalytic site [active] 767453004128 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 767453004129 substrate binding site [chemical binding]; other site 767453004130 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 767453004131 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767453004132 ATP binding site [chemical binding]; other site 767453004133 putative Mg++ binding site [ion binding]; other site 767453004134 helicase superfamily c-terminal domain; Region: HELICc; smart00490 767453004135 ATP-binding site [chemical binding]; other site 767453004136 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 767453004137 Flavoprotein; Region: Flavoprotein; pfam02441 767453004138 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 767453004139 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 767453004140 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 767453004141 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 767453004142 catalytic site [active] 767453004143 G-X2-G-X-G-K; other site 767453004144 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453004145 Integrase core domain; Region: rve; pfam00665 767453004146 Helix-turn-helix domain; Region: HTH_38; pfam13936 767453004147 Winged helix-turn helix; Region: HTH_29; pfam13551 767453004148 Homeodomain-like domain; Region: HTH_32; pfam13565 767453004149 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 767453004150 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 767453004151 Walker A/P-loop; other site 767453004152 ATP binding site [chemical binding]; other site 767453004153 Q-loop/lid; other site 767453004154 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 767453004155 ABC transporter signature motif; other site 767453004156 Walker B; other site 767453004157 D-loop; other site 767453004158 H-loop/switch region; other site 767453004159 Arginine repressor [Transcription]; Region: ArgR; COG1438 767453004160 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 767453004161 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 767453004162 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 767453004163 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 767453004164 RNA binding surface [nucleotide binding]; other site 767453004165 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 767453004166 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 767453004167 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 767453004168 substrate binding pocket [chemical binding]; other site 767453004169 chain length determination region; other site 767453004170 substrate-Mg2+ binding site; other site 767453004171 catalytic residues [active] 767453004172 aspartate-rich region 1; other site 767453004173 active site lid residues [active] 767453004174 aspartate-rich region 2; other site 767453004175 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 767453004176 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 767453004177 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 767453004178 generic binding surface II; other site 767453004179 generic binding surface I; other site 767453004180 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 767453004181 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 767453004182 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 767453004183 homodimer interface [polypeptide binding]; other site 767453004184 NADP binding site [chemical binding]; other site 767453004185 substrate binding site [chemical binding]; other site 767453004186 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 767453004187 putative RNA binding site [nucleotide binding]; other site 767453004188 Asp23 family; Region: Asp23; pfam03780 767453004189 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 767453004190 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 767453004191 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 767453004192 active site 767453004193 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 767453004194 Protein of unknown function (DUF464); Region: DUF464; pfam04327 767453004195 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 767453004196 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 767453004197 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767453004198 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 767453004199 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 767453004200 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 767453004201 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 767453004202 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 767453004203 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 767453004204 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 767453004205 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 767453004206 active site residue [active] 767453004207 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 767453004208 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 767453004209 nucleotide binding site [chemical binding]; other site 767453004210 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 767453004211 Rhomboid family; Region: Rhomboid; pfam01694 767453004212 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 767453004213 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 767453004214 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 767453004215 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 767453004216 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 767453004217 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 767453004218 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 767453004219 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 767453004220 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 767453004221 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 767453004222 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 767453004223 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 767453004224 Sugar specificity; other site 767453004225 Pyrimidine base specificity; other site 767453004226 ATP-binding site [chemical binding]; other site 767453004227 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 767453004228 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 767453004229 putative tRNA-binding site [nucleotide binding]; other site 767453004230 B3/4 domain; Region: B3_4; pfam03483 767453004231 tRNA synthetase B5 domain; Region: B5; smart00874 767453004232 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 767453004233 dimer interface [polypeptide binding]; other site 767453004234 motif 1; other site 767453004235 motif 3; other site 767453004236 motif 2; other site 767453004237 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 767453004238 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 767453004239 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 767453004240 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 767453004241 dimer interface [polypeptide binding]; other site 767453004242 motif 1; other site 767453004243 active site 767453004244 motif 2; other site 767453004245 motif 3; other site 767453004246 Predicted transcriptional regulators [Transcription]; Region: COG1733 767453004247 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 767453004248 HD domain; Region: HD; pfam01966 767453004249 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 767453004250 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 767453004251 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 767453004252 Acylphosphatase; Region: Acylphosphatase; pfam00708 767453004253 OxaA-like protein precursor; Provisional; Region: PRK02463 767453004254 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 767453004255 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 767453004256 active site 767453004257 catalytic residues [active] 767453004258 metal binding site [ion binding]; metal-binding site 767453004259 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 767453004260 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 767453004261 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 767453004262 HAMP domain; Region: HAMP; pfam00672 767453004263 dimerization interface [polypeptide binding]; other site 767453004264 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767453004265 dimer interface [polypeptide binding]; other site 767453004266 phosphorylation site [posttranslational modification] 767453004267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767453004268 ATP binding site [chemical binding]; other site 767453004269 Mg2+ binding site [ion binding]; other site 767453004270 G-X-G motif; other site 767453004271 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 767453004272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767453004273 active site 767453004274 phosphorylation site [posttranslational modification] 767453004275 intermolecular recognition site; other site 767453004276 dimerization interface [polypeptide binding]; other site 767453004277 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767453004278 DNA binding site [nucleotide binding] 767453004279 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 767453004280 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 767453004281 hypothetical protein; Provisional; Region: PRK13670 767453004282 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 767453004283 Methyltransferase domain; Region: Methyltransf_18; pfam12847 767453004284 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 767453004285 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767453004286 Zn2+ binding site [ion binding]; other site 767453004287 Mg2+ binding site [ion binding]; other site 767453004288 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 767453004289 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 767453004290 active site 767453004291 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 767453004292 GTPase YqeH; Provisional; Region: PRK13796 767453004293 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 767453004294 GTP/Mg2+ binding site [chemical binding]; other site 767453004295 G4 box; other site 767453004296 G5 box; other site 767453004297 G1 box; other site 767453004298 Switch I region; other site 767453004299 G2 box; other site 767453004300 G3 box; other site 767453004301 Switch II region; other site 767453004302 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 767453004303 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767453004304 active site 767453004305 motif I; other site 767453004306 motif II; other site 767453004307 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 767453004308 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 767453004309 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 767453004310 23S rRNA binding site [nucleotide binding]; other site 767453004311 L21 binding site [polypeptide binding]; other site 767453004312 L13 binding site [polypeptide binding]; other site 767453004313 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 767453004314 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 767453004315 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 767453004316 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 767453004317 primosomal protein DnaI; Reviewed; Region: PRK08939 767453004318 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 767453004319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767453004320 Walker A motif; other site 767453004321 ATP binding site [chemical binding]; other site 767453004322 Walker B motif; other site 767453004323 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 767453004324 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 767453004325 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 767453004326 ATP cone domain; Region: ATP-cone; pfam03477 767453004327 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 767453004328 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 767453004329 CoA-binding site [chemical binding]; other site 767453004330 ATP-binding [chemical binding]; other site 767453004331 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 767453004332 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 767453004333 DNA binding site [nucleotide binding] 767453004334 catalytic residue [active] 767453004335 H2TH interface [polypeptide binding]; other site 767453004336 putative catalytic residues [active] 767453004337 turnover-facilitating residue; other site 767453004338 intercalation triad [nucleotide binding]; other site 767453004339 8OG recognition residue [nucleotide binding]; other site 767453004340 putative reading head residues; other site 767453004341 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 767453004342 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 767453004343 DNA polymerase I; Provisional; Region: PRK05755 767453004344 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 767453004345 active site 767453004346 metal binding site 1 [ion binding]; metal-binding site 767453004347 putative 5' ssDNA interaction site; other site 767453004348 metal binding site 3; metal-binding site 767453004349 metal binding site 2 [ion binding]; metal-binding site 767453004350 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 767453004351 putative DNA binding site [nucleotide binding]; other site 767453004352 putative metal binding site [ion binding]; other site 767453004353 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 767453004354 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 767453004355 active site 767453004356 DNA binding site [nucleotide binding] 767453004357 catalytic site [active] 767453004358 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 767453004359 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 767453004360 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 767453004361 nucleophilic elbow; other site 767453004362 catalytic site [active] 767453004363 catalytic triad; other site 767453004364 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 767453004365 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 767453004366 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 767453004367 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 767453004368 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767453004369 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767453004370 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 767453004371 putative tRNA-binding site [nucleotide binding]; other site 767453004372 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 767453004373 catalytic residues [active] 767453004374 Predicted small secreted protein [Function unknown]; Region: COG5584 767453004375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767453004376 S-adenosylmethionine binding site [chemical binding]; other site 767453004377 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 767453004378 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767453004379 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767453004380 Walker A/P-loop; other site 767453004381 ATP binding site [chemical binding]; other site 767453004382 Q-loop/lid; other site 767453004383 ABC transporter signature motif; other site 767453004384 Walker B; other site 767453004385 D-loop; other site 767453004386 H-loop/switch region; other site 767453004387 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 767453004388 HIT family signature motif; other site 767453004389 catalytic residue [active] 767453004390 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 767453004391 SurA N-terminal domain; Region: SurA_N; pfam09312 767453004392 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 767453004393 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 767453004394 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 767453004395 generic binding surface II; other site 767453004396 generic binding surface I; other site 767453004397 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 767453004398 Zn2+ binding site [ion binding]; other site 767453004399 Mg2+ binding site [ion binding]; other site 767453004400 Protein of unknown function (DUF964); Region: DUF964; cl01483 767453004401 Transglycosylase; Region: Transgly; pfam00912 767453004402 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 767453004403 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 767453004404 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 767453004405 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 767453004406 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 767453004407 active site 767453004408 HIGH motif; other site 767453004409 KMSK motif region; other site 767453004410 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 767453004411 tRNA binding surface [nucleotide binding]; other site 767453004412 anticodon binding site; other site 767453004413 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 767453004414 dihydropteroate synthase; Region: DHPS; TIGR01496 767453004415 substrate binding pocket [chemical binding]; other site 767453004416 dimer interface [polypeptide binding]; other site 767453004417 inhibitor binding site; inhibition site 767453004418 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 767453004419 active site 767453004420 dimerization interface [polypeptide binding]; other site 767453004421 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 767453004422 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767453004423 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767453004424 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 767453004425 GTP cyclohydrolase I; Provisional; Region: PLN03044 767453004426 active site 767453004427 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 767453004428 catalytic center binding site [active] 767453004429 ATP binding site [chemical binding]; other site 767453004430 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 767453004431 active site 767453004432 CAAX protease self-immunity; Region: Abi; pfam02517 767453004433 Transcriptional regulators [Transcription]; Region: PurR; COG1609 767453004434 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767453004435 DNA binding site [nucleotide binding] 767453004436 domain linker motif; other site 767453004437 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 767453004438 dimerization interface [polypeptide binding]; other site 767453004439 ligand binding site [chemical binding]; other site 767453004440 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 767453004441 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 767453004442 Substrate-binding site [chemical binding]; other site 767453004443 Substrate specificity [chemical binding]; other site 767453004444 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 767453004445 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 767453004446 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 767453004447 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 767453004448 Ligand Binding Site [chemical binding]; other site 767453004449 dipeptidase PepV; Reviewed; Region: PRK07318 767453004450 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 767453004451 active site 767453004452 metal binding site [ion binding]; metal-binding site 767453004453 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 767453004454 putative substrate binding site [chemical binding]; other site 767453004455 putative ATP binding site [chemical binding]; other site 767453004456 Domain of unknown function DUF302; Region: DUF302; cl01364 767453004457 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 767453004458 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 767453004459 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 767453004460 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 767453004461 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 767453004462 HIGH motif; other site 767453004463 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 767453004464 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767453004465 active site 767453004466 KMSKS motif; other site 767453004467 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 767453004468 tRNA binding surface [nucleotide binding]; other site 767453004469 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 767453004470 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 767453004471 active site 767453004472 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 767453004473 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 767453004474 putative catalytic cysteine [active] 767453004475 gamma-glutamyl kinase; Provisional; Region: PRK05429 767453004476 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 767453004477 nucleotide binding site [chemical binding]; other site 767453004478 homotetrameric interface [polypeptide binding]; other site 767453004479 putative phosphate binding site [ion binding]; other site 767453004480 putative allosteric binding site; other site 767453004481 S-adenosylmethionine synthetase; Validated; Region: PRK05250 767453004482 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 767453004483 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 767453004484 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 767453004485 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 767453004486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453004487 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 767453004488 putative substrate translocation pore; other site 767453004489 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 767453004490 metal binding site 2 [ion binding]; metal-binding site 767453004491 putative DNA binding helix; other site 767453004492 metal binding site 1 [ion binding]; metal-binding site 767453004493 dimer interface [polypeptide binding]; other site 767453004494 structural Zn2+ binding site [ion binding]; other site 767453004495 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 767453004496 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767453004497 dimerization interface [polypeptide binding]; other site 767453004498 Probable transposase; Region: OrfB_IS605; pfam01385 767453004499 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453004500 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767453004501 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453004502 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453004503 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 767453004504 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 767453004505 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 767453004506 putative dimer interface [polypeptide binding]; other site 767453004507 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 767453004508 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767453004509 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 767453004510 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 767453004511 tetramer interface [polypeptide binding]; other site 767453004512 catalytic Zn binding site [ion binding]; other site 767453004513 NADP binding site [chemical binding]; other site 767453004514 xanthine permease; Region: pbuX; TIGR03173 767453004515 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 767453004516 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 767453004517 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 767453004518 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 767453004519 Class III ribonucleotide reductase; Region: RNR_III; cd01675 767453004520 effector binding site; other site 767453004521 active site 767453004522 Zn binding site [ion binding]; other site 767453004523 glycine loop; other site 767453004524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767453004525 dimer interface [polypeptide binding]; other site 767453004526 conserved gate region; other site 767453004527 putative PBP binding loops; other site 767453004528 ABC-ATPase subunit interface; other site 767453004529 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767453004530 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767453004531 substrate binding pocket [chemical binding]; other site 767453004532 membrane-bound complex binding site; other site 767453004533 hinge residues; other site 767453004534 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 767453004535 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 767453004536 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 767453004537 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 767453004538 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767453004539 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 767453004540 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 767453004541 putative ADP-binding pocket [chemical binding]; other site 767453004542 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 767453004543 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 767453004544 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 767453004545 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 767453004546 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 767453004547 dimerization domain swap beta strand [polypeptide binding]; other site 767453004548 regulatory protein interface [polypeptide binding]; other site 767453004549 active site 767453004550 regulatory phosphorylation site [posttranslational modification]; other site 767453004551 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767453004552 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 767453004553 Walker A motif; other site 767453004554 ATP binding site [chemical binding]; other site 767453004555 Walker B motif; other site 767453004556 arginine finger; other site 767453004557 UvrB/uvrC motif; Region: UVR; pfam02151 767453004558 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767453004559 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 767453004560 Walker A motif; other site 767453004561 ATP binding site [chemical binding]; other site 767453004562 Walker B motif; other site 767453004563 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 767453004564 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 767453004565 nudix motif; other site 767453004566 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 767453004567 Isochorismatase family; Region: Isochorismatase; pfam00857 767453004568 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 767453004569 catalytic triad [active] 767453004570 conserved cis-peptide bond; other site 767453004571 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 767453004572 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 767453004573 active site 767453004574 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 767453004575 Predicted membrane protein [Function unknown]; Region: COG4684 767453004576 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 767453004577 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 767453004578 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 767453004579 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 767453004580 EamA-like transporter family; Region: EamA; pfam00892 767453004581 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 767453004582 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 767453004583 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 767453004584 HTH-like domain; Region: HTH_21; pfam13276 767453004585 Integrase core domain; Region: rve; pfam00665 767453004586 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767453004587 Helix-turn-helix domain; Region: HTH_28; pfam13518 767453004588 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767453004589 MULE transposase domain; Region: MULE; pfam10551 767453004590 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 767453004591 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 767453004592 Walker A/P-loop; other site 767453004593 ATP binding site [chemical binding]; other site 767453004594 Q-loop/lid; other site 767453004595 ABC transporter signature motif; other site 767453004596 Walker B; other site 767453004597 D-loop; other site 767453004598 H-loop/switch region; other site 767453004599 Predicted transcriptional regulators [Transcription]; Region: COG1725 767453004600 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767453004601 DNA-binding site [nucleotide binding]; DNA binding site 767453004602 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 767453004603 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 767453004604 NAD binding site [chemical binding]; other site 767453004605 substrate binding site [chemical binding]; other site 767453004606 homodimer interface [polypeptide binding]; other site 767453004607 active site 767453004608 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 767453004609 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 767453004610 active site 767453004611 Predicted integral membrane protein [Function unknown]; Region: COG5617 767453004612 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 767453004613 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 767453004614 G1 box; other site 767453004615 putative GEF interaction site [polypeptide binding]; other site 767453004616 GTP/Mg2+ binding site [chemical binding]; other site 767453004617 Switch I region; other site 767453004618 G2 box; other site 767453004619 G3 box; other site 767453004620 Switch II region; other site 767453004621 G4 box; other site 767453004622 G5 box; other site 767453004623 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 767453004624 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 767453004625 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 767453004626 Ligand binding site; other site 767453004627 Putative Catalytic site; other site 767453004628 DXD motif; other site 767453004629 putative transposase OrfB; Reviewed; Region: PHA02517 767453004630 HTH-like domain; Region: HTH_21; pfam13276 767453004631 Integrase core domain; Region: rve; pfam00665 767453004632 Integrase core domain; Region: rve_3; pfam13683 767453004633 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767453004634 Transposase; Region: HTH_Tnp_1; cl17663 767453004635 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453004636 Integrase core domain; Region: rve; pfam00665 767453004637 conserved hypothetical integral membrane protein; Region: TIGR03766 767453004638 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767453004639 MULE transposase domain; Region: MULE; pfam10551 767453004640 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453004641 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 767453004642 Domain of unknown function DUF20; Region: UPF0118; pfam01594 767453004643 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 767453004644 Ligand binding site; other site 767453004645 Putative Catalytic site; other site 767453004646 DXD motif; other site 767453004647 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 767453004648 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 767453004649 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 767453004650 NlpC/P60 family; Region: NLPC_P60; pfam00877 767453004651 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 767453004652 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767453004653 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767453004654 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 767453004655 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 767453004656 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 767453004657 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 767453004658 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 767453004659 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 767453004660 UDP-galactopyranose mutase; Region: GLF; pfam03275 767453004661 Core-2/I-Branching enzyme; Region: Branch; pfam02485 767453004662 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 767453004663 Acyltransferase family; Region: Acyl_transf_3; pfam01757 767453004664 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 767453004665 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 767453004666 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 767453004667 Chain length determinant protein; Region: Wzz; cl15801 767453004668 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 767453004669 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 767453004670 Bacterial sugar transferase; Region: Bac_transf; pfam02397 767453004671 recombination regulator RecX; Provisional; Region: recX; PRK14135 767453004672 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 767453004673 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 767453004674 Sulfatase; Region: Sulfatase; cl17466 767453004675 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 767453004676 active site 767453004677 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 767453004678 Predicted membrane protein [Function unknown]; Region: COG2246 767453004679 GtrA-like protein; Region: GtrA; pfam04138 767453004680 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 767453004681 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 767453004682 ATP binding site [chemical binding]; other site 767453004683 putative Mg++ binding site [ion binding]; other site 767453004684 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767453004685 nucleotide binding region [chemical binding]; other site 767453004686 ATP-binding site [chemical binding]; other site 767453004687 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 767453004688 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 767453004689 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 767453004690 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 767453004691 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 767453004692 NAD(P) binding site [chemical binding]; other site 767453004693 LDH/MDH dimer interface [polypeptide binding]; other site 767453004694 substrate binding site [chemical binding]; other site 767453004695 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 767453004696 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 767453004697 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767453004698 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 767453004699 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 767453004700 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767453004701 Walker A/P-loop; other site 767453004702 ATP binding site [chemical binding]; other site 767453004703 ABC transporter signature motif; other site 767453004704 Walker B; other site 767453004705 D-loop; other site 767453004706 H-loop/switch region; other site 767453004707 ABC transporter; Region: ABC_tran_2; pfam12848 767453004708 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767453004709 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 767453004710 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 767453004711 dimerization interface [polypeptide binding]; other site 767453004712 DPS ferroxidase diiron center [ion binding]; other site 767453004713 ion pore; other site 767453004714 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 767453004715 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767453004716 dimerization interface [polypeptide binding]; other site 767453004717 putative DNA binding site [nucleotide binding]; other site 767453004718 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 767453004719 putative Zn2+ binding site [ion binding]; other site 767453004720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453004721 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767453004722 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 767453004723 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 767453004724 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 767453004725 DNA binding site [nucleotide binding] 767453004726 active site 767453004727 CAAX protease self-immunity; Region: Abi; pfam02517 767453004728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767453004729 S-adenosylmethionine binding site [chemical binding]; other site 767453004730 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 767453004731 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 767453004732 Predicted transcriptional regulator [Transcription]; Region: COG1959 767453004733 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453004734 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453004735 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453004736 Probable transposase; Region: OrfB_IS605; pfam01385 767453004737 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453004738 multicopper oxidase; Provisional; Region: PRK10965 767453004739 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 767453004740 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 767453004741 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 767453004742 putative deacylase active site [active] 767453004743 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 767453004744 Amidinotransferase; Region: Amidinotransf; cl12043 767453004745 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 767453004746 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 767453004747 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 767453004748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453004749 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453004750 Probable transposase; Region: OrfB_IS605; pfam01385 767453004751 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453004752 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453004753 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 767453004754 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 767453004755 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 767453004756 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 767453004757 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767453004758 MULE transposase domain; Region: MULE; pfam10551 767453004759 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453004760 Integrase core domain; Region: rve; pfam00665 767453004761 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 767453004762 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767453004763 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767453004764 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 767453004765 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 767453004766 HTH-like domain; Region: HTH_21; pfam13276 767453004767 Integrase core domain; Region: rve; pfam00665 767453004768 Helix-turn-helix domain; Region: HTH_28; pfam13518 767453004769 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 767453004770 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 767453004771 ligand binding site [chemical binding]; other site 767453004772 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 767453004773 putative switch regulator; other site 767453004774 non-specific DNA interactions [nucleotide binding]; other site 767453004775 DNA binding site [nucleotide binding] 767453004776 sequence specific DNA binding site [nucleotide binding]; other site 767453004777 putative cAMP binding site [chemical binding]; other site 767453004778 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 767453004779 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 767453004780 metal-binding site [ion binding] 767453004781 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 767453004782 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767453004783 Soluble P-type ATPase [General function prediction only]; Region: COG4087 767453004784 Transposase IS200 like; Region: Y1_Tnp; cl00848 767453004785 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453004786 Helix-turn-helix domain; Region: HTH_38; pfam13936 767453004787 Integrase core domain; Region: rve; pfam00665 767453004788 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767453004789 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767453004790 non-specific DNA binding site [nucleotide binding]; other site 767453004791 salt bridge; other site 767453004792 sequence-specific DNA binding site [nucleotide binding]; other site 767453004793 Pup-ligase protein; Region: Pup_ligase; cl15463 767453004794 TRAM domain; Region: TRAM; cl01282 767453004795 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 767453004796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 767453004797 S-adenosylmethionine binding site [chemical binding]; other site 767453004798 putative lipid kinase; Reviewed; Region: PRK13055 767453004799 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 767453004800 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 767453004801 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 767453004802 GatB domain; Region: GatB_Yqey; smart00845 767453004803 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 767453004804 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 767453004805 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 767453004806 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 767453004807 putative dimer interface [polypeptide binding]; other site 767453004808 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 767453004809 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 767453004810 putative dimer interface [polypeptide binding]; other site 767453004811 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 767453004812 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 767453004813 nucleotide binding pocket [chemical binding]; other site 767453004814 K-X-D-G motif; other site 767453004815 catalytic site [active] 767453004816 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 767453004817 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 767453004818 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 767453004819 Dimer interface [polypeptide binding]; other site 767453004820 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 767453004821 Part of AAA domain; Region: AAA_19; pfam13245 767453004822 Family description; Region: UvrD_C_2; pfam13538 767453004823 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767453004824 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767453004825 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 767453004826 active site 767453004827 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 767453004828 acetoin reductase; Validated; Region: PRK08643 767453004829 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 767453004830 NAD binding site [chemical binding]; other site 767453004831 homotetramer interface [polypeptide binding]; other site 767453004832 homodimer interface [polypeptide binding]; other site 767453004833 active site 767453004834 substrate binding site [chemical binding]; other site 767453004835 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453004836 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767453004837 Probable transposase; Region: OrfB_IS605; pfam01385 767453004838 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453004839 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453004840 Transposase IS200 like; Region: Y1_Tnp; cl00848 767453004841 Helix-turn-helix domain; Region: HTH_28; pfam13518 767453004842 HTH-like domain; Region: HTH_21; pfam13276 767453004843 Integrase core domain; Region: rve; pfam00665 767453004844 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767453004845 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767453004846 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 767453004847 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 767453004848 23S rRNA interface [nucleotide binding]; other site 767453004849 L3 interface [polypeptide binding]; other site 767453004850 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 767453004851 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 767453004852 dimerization interface 3.5A [polypeptide binding]; other site 767453004853 active site 767453004854 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 767453004855 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 767453004856 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767453004857 Walker A/P-loop; other site 767453004858 ATP binding site [chemical binding]; other site 767453004859 Q-loop/lid; other site 767453004860 ABC transporter signature motif; other site 767453004861 Walker B; other site 767453004862 D-loop; other site 767453004863 H-loop/switch region; other site 767453004864 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 767453004865 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767453004866 Walker A/P-loop; other site 767453004867 ATP binding site [chemical binding]; other site 767453004868 Q-loop/lid; other site 767453004869 ABC transporter signature motif; other site 767453004870 Walker B; other site 767453004871 D-loop; other site 767453004872 H-loop/switch region; other site 767453004873 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 767453004874 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 767453004875 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 767453004876 alphaNTD homodimer interface [polypeptide binding]; other site 767453004877 alphaNTD - beta interaction site [polypeptide binding]; other site 767453004878 alphaNTD - beta' interaction site [polypeptide binding]; other site 767453004879 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 767453004880 30S ribosomal protein S11; Validated; Region: PRK05309 767453004881 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 767453004882 30S ribosomal protein S13; Region: bact_S13; TIGR03631 767453004883 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 767453004884 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 767453004885 rRNA binding site [nucleotide binding]; other site 767453004886 predicted 30S ribosome binding site; other site 767453004887 adenylate kinase; Reviewed; Region: adk; PRK00279 767453004888 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 767453004889 AMP-binding site [chemical binding]; other site 767453004890 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 767453004891 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 767453004892 SecY translocase; Region: SecY; pfam00344 767453004893 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 767453004894 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 767453004895 23S rRNA binding site [nucleotide binding]; other site 767453004896 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 767453004897 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 767453004898 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 767453004899 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 767453004900 5S rRNA interface [nucleotide binding]; other site 767453004901 L27 interface [polypeptide binding]; other site 767453004902 23S rRNA interface [nucleotide binding]; other site 767453004903 L5 interface [polypeptide binding]; other site 767453004904 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 767453004905 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 767453004906 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 767453004907 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 767453004908 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 767453004909 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 767453004910 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 767453004911 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 767453004912 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 767453004913 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 767453004914 RNA binding site [nucleotide binding]; other site 767453004915 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 767453004916 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 767453004917 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 767453004918 23S rRNA interface [nucleotide binding]; other site 767453004919 putative translocon interaction site; other site 767453004920 signal recognition particle (SRP54) interaction site; other site 767453004921 L23 interface [polypeptide binding]; other site 767453004922 trigger factor interaction site; other site 767453004923 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 767453004924 23S rRNA interface [nucleotide binding]; other site 767453004925 5S rRNA interface [nucleotide binding]; other site 767453004926 putative antibiotic binding site [chemical binding]; other site 767453004927 L25 interface [polypeptide binding]; other site 767453004928 L27 interface [polypeptide binding]; other site 767453004929 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 767453004930 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 767453004931 G-X-X-G motif; other site 767453004932 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 767453004933 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 767453004934 putative translocon binding site; other site 767453004935 protein-rRNA interface [nucleotide binding]; other site 767453004936 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 767453004937 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 767453004938 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 767453004939 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 767453004940 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 767453004941 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 767453004942 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 767453004943 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 767453004944 elongation factor G; Reviewed; Region: PRK12739 767453004945 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 767453004946 G1 box; other site 767453004947 putative GEF interaction site [polypeptide binding]; other site 767453004948 GTP/Mg2+ binding site [chemical binding]; other site 767453004949 Switch I region; other site 767453004950 G2 box; other site 767453004951 G3 box; other site 767453004952 Switch II region; other site 767453004953 G4 box; other site 767453004954 G5 box; other site 767453004955 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 767453004956 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 767453004957 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 767453004958 30S ribosomal protein S7; Validated; Region: PRK05302 767453004959 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 767453004960 S17 interaction site [polypeptide binding]; other site 767453004961 S8 interaction site; other site 767453004962 16S rRNA interaction site [nucleotide binding]; other site 767453004963 streptomycin interaction site [chemical binding]; other site 767453004964 23S rRNA interaction site [nucleotide binding]; other site 767453004965 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 767453004966 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 767453004967 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 767453004968 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 767453004969 Predicted membrane protein [Function unknown]; Region: COG3371 767453004970 Protein of unknown function (DUF998); Region: DUF998; pfam06197 767453004971 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 767453004972 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 767453004973 catalytic triad [active] 767453004974 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 767453004975 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 767453004976 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 767453004977 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 767453004978 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 767453004979 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 767453004980 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 767453004981 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 767453004982 DNA binding site [nucleotide binding] 767453004983 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 767453004984 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 767453004985 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 767453004986 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 767453004987 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 767453004988 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 767453004989 RPB1 interaction site [polypeptide binding]; other site 767453004990 RPB12 interaction site [polypeptide binding]; other site 767453004991 RPB10 interaction site [polypeptide binding]; other site 767453004992 RPB11 interaction site [polypeptide binding]; other site 767453004993 RPB3 interaction site [polypeptide binding]; other site 767453004994 RPB12 interaction site [polypeptide binding]; other site 767453004995 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767453004996 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767453004997 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 767453004998 Clp amino terminal domain; Region: Clp_N; pfam02861 767453004999 Clp amino terminal domain; Region: Clp_N; pfam02861 767453005000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767453005001 Walker A motif; other site 767453005002 ATP binding site [chemical binding]; other site 767453005003 Walker B motif; other site 767453005004 arginine finger; other site 767453005005 UvrB/uvrC motif; Region: UVR; pfam02151 767453005006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767453005007 Walker A motif; other site 767453005008 ATP binding site [chemical binding]; other site 767453005009 Walker B motif; other site 767453005010 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 767453005011 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 767453005012 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453005013 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453005014 Probable transposase; Region: OrfB_IS605; pfam01385 767453005015 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453005016 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453005017 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 767453005018 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 767453005019 NAD binding site [chemical binding]; other site 767453005020 substrate binding site [chemical binding]; other site 767453005021 catalytic Zn binding site [ion binding]; other site 767453005022 tetramer interface [polypeptide binding]; other site 767453005023 structural Zn binding site [ion binding]; other site 767453005024 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 767453005025 B3/4 domain; Region: B3_4; pfam03483 767453005026 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 767453005027 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 767453005028 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 767453005029 active site 767453005030 substrate binding site [chemical binding]; other site 767453005031 trimer interface [polypeptide binding]; other site 767453005032 CoA binding site [chemical binding]; other site 767453005033 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 767453005034 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767453005035 classical (c) SDRs; Region: SDR_c; cd05233 767453005036 active site 767453005037 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767453005038 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 767453005039 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 767453005040 Substrate-binding site [chemical binding]; other site 767453005041 Substrate specificity [chemical binding]; other site 767453005042 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 767453005043 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 767453005044 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 767453005045 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 767453005046 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 767453005047 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 767453005048 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 767453005049 active site 767453005050 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 767453005051 Uncharacterized conserved protein [Function unknown]; Region: COG2966 767453005052 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 767453005053 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 767453005054 DNA-binding site [nucleotide binding]; DNA binding site 767453005055 RNA-binding motif; other site 767453005056 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 767453005057 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 767453005058 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 767453005059 FeoA domain; Region: FeoA; pfam04023 767453005060 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 767453005061 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 767453005062 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 767453005063 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 767453005064 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 767453005065 Ligand Binding Site [chemical binding]; other site 767453005066 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767453005067 Coenzyme A binding pocket [chemical binding]; other site 767453005068 CAAX protease self-immunity; Region: Abi; pfam02517 767453005069 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 767453005070 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 767453005071 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 767453005072 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 767453005073 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 767453005074 DNA binding residues [nucleotide binding] 767453005075 putative dimer interface [polypeptide binding]; other site 767453005076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453005077 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767453005078 putative substrate translocation pore; other site 767453005079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453005080 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 767453005081 substrate binding site [chemical binding]; other site 767453005082 Mn binding site [ion binding]; other site 767453005083 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 767453005084 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 767453005085 active site 767453005086 Predicted integral membrane protein [Function unknown]; Region: COG0392 767453005087 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 767453005088 DJ-1 family protein; Region: not_thiJ; TIGR01383 767453005089 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 767453005090 conserved cys residue [active] 767453005091 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 767453005092 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 767453005093 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 767453005094 active site 767453005095 Fe-S cluster binding site [ion binding]; other site 767453005096 Uncharacterized conserved protein [Function unknown]; Region: COG2966 767453005097 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 767453005098 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 767453005099 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767453005100 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767453005101 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 767453005102 dimerization interface [polypeptide binding]; other site 767453005103 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767453005104 Helix-turn-helix domain; Region: HTH_28; pfam13518 767453005105 Helix-turn-helix domain; Region: HTH_28; pfam13518 767453005106 HTH-like domain; Region: HTH_21; pfam13276 767453005107 Integrase core domain; Region: rve; pfam00665 767453005108 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 767453005109 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 767453005110 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 767453005111 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 767453005112 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 767453005113 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 767453005114 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 767453005115 citrate lyase subunit gamma; Provisional; Region: PRK13253 767453005116 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 767453005117 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 767453005118 active site 767453005119 nucleotide binding site [chemical binding]; other site 767453005120 HIGH motif; other site 767453005121 KMSKS motif; other site 767453005122 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 767453005123 Malic enzyme, N-terminal domain; Region: malic; pfam00390 767453005124 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 767453005125 NAD(P) binding pocket [chemical binding]; other site 767453005126 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 767453005127 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 767453005128 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 767453005129 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 767453005130 transmembrane helices; other site 767453005131 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 767453005132 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 767453005133 tetramer (dimer of dimers) interface [polypeptide binding]; other site 767453005134 NAD binding site [chemical binding]; other site 767453005135 dimer interface [polypeptide binding]; other site 767453005136 substrate binding site [chemical binding]; other site 767453005137 L-aspartate oxidase; Provisional; Region: PRK06175 767453005138 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 767453005139 fumarate hydratase; Reviewed; Region: fumC; PRK00485 767453005140 Class II fumarases; Region: Fumarase_classII; cd01362 767453005141 active site 767453005142 tetramer interface [polypeptide binding]; other site 767453005143 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767453005144 Predicted flavoprotein [General function prediction only]; Region: COG0431 767453005145 Predicted flavoprotein [General function prediction only]; Region: COG0431 767453005146 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767453005147 PAS domain; Region: PAS_10; pfam13596 767453005148 malate dehydrogenase; Provisional; Region: PRK13529 767453005149 Malic enzyme, N-terminal domain; Region: malic; pfam00390 767453005150 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 767453005151 NAD(P) binding site [chemical binding]; other site 767453005152 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767453005153 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767453005154 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 767453005155 dimerization interface [polypeptide binding]; other site 767453005156 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767453005157 Transposase; Region: HTH_Tnp_1; cl17663 767453005158 Helix-turn-helix domain; Region: HTH_28; pfam13518 767453005159 HTH-like domain; Region: HTH_21; pfam13276 767453005160 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 767453005161 active site 767453005162 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 767453005163 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 767453005164 active site turn [active] 767453005165 phosphorylation site [posttranslational modification] 767453005166 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 767453005167 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 767453005168 HPr interaction site; other site 767453005169 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767453005170 active site 767453005171 phosphorylation site [posttranslational modification] 767453005172 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 767453005173 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 767453005174 putative NAD(P) binding site [chemical binding]; other site 767453005175 putative substrate binding site [chemical binding]; other site 767453005176 catalytic Zn binding site [ion binding]; other site 767453005177 structural Zn binding site [ion binding]; other site 767453005178 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 767453005179 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 767453005180 substrate binding [chemical binding]; other site 767453005181 active site 767453005182 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 767453005183 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 767453005184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 767453005185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767453005186 NADH(P)-binding; Region: NAD_binding_10; pfam13460 767453005187 NAD(P) binding site [chemical binding]; other site 767453005188 active site 767453005189 Transcriptional regulator [Transcription]; Region: LysR; COG0583 767453005190 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 767453005191 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 767453005192 dimerization interface [polypeptide binding]; other site 767453005193 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 767453005194 inner membrane transporter YjeM; Provisional; Region: PRK15238 767453005195 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 767453005196 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 767453005197 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 767453005198 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 767453005199 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 767453005200 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 767453005201 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 767453005202 active site 767453005203 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 767453005204 homodimer interface [polypeptide binding]; other site 767453005205 chemical substrate binding site [chemical binding]; other site 767453005206 oligomer interface [polypeptide binding]; other site 767453005207 metal binding site [ion binding]; metal-binding site 767453005208 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 767453005209 PLD-like domain; Region: PLDc_2; pfam13091 767453005210 putative homodimer interface [polypeptide binding]; other site 767453005211 putative active site [active] 767453005212 catalytic site [active] 767453005213 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 767453005214 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 767453005215 ATP binding site [chemical binding]; other site 767453005216 putative Mg++ binding site [ion binding]; other site 767453005217 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 767453005218 nucleotide binding region [chemical binding]; other site 767453005219 ATP-binding site [chemical binding]; other site 767453005220 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 767453005221 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 767453005222 active site 767453005223 8-oxo-dGMP binding site [chemical binding]; other site 767453005224 nudix motif; other site 767453005225 metal binding site [ion binding]; metal-binding site 767453005226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453005227 WYL domain; Region: WYL; pfam13280 767453005228 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 767453005229 S-ribosylhomocysteinase; Provisional; Region: PRK02260 767453005230 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 767453005231 substrate binding site [chemical binding]; other site 767453005232 THF binding site; other site 767453005233 zinc-binding site [ion binding]; other site 767453005234 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 767453005235 dimer interface [polypeptide binding]; other site 767453005236 active site 767453005237 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 767453005238 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 767453005239 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767453005240 Coenzyme A binding pocket [chemical binding]; other site 767453005241 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 767453005242 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 767453005243 active site 767453005244 DNA binding site [nucleotide binding] 767453005245 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453005246 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453005247 Probable transposase; Region: OrfB_IS605; pfam01385 767453005248 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453005249 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453005250 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 767453005251 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 767453005252 DNA binding residues [nucleotide binding] 767453005253 putative dimer interface [polypeptide binding]; other site 767453005254 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 767453005255 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 767453005256 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 767453005257 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 767453005258 carboxyltransferase (CT) interaction site; other site 767453005259 biotinylation site [posttranslational modification]; other site 767453005260 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 767453005261 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 767453005262 ATP-grasp domain; Region: ATP-grasp_4; cl17255 767453005263 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 767453005264 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 767453005265 putative active site [active] 767453005266 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 767453005267 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 767453005268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453005269 Major Facilitator Superfamily; Region: MFS_1; pfam07690 767453005270 putative substrate translocation pore; other site 767453005271 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 767453005272 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767453005273 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767453005274 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 767453005275 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 767453005276 catalytic residues [active] 767453005277 Predicted permeases [General function prediction only]; Region: COG0679 767453005278 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453005279 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453005280 Probable transposase; Region: OrfB_IS605; pfam01385 767453005281 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453005282 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453005283 Transposase IS200 like; Region: Y1_Tnp; cl00848 767453005284 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 767453005285 Transposase; Region: DDE_Tnp_ISL3; pfam01610 767453005286 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 767453005287 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 767453005288 inhibitor-cofactor binding pocket; inhibition site 767453005289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 767453005290 catalytic residue [active] 767453005291 amino acid transporter; Region: 2A0306; TIGR00909 767453005292 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 767453005293 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 767453005294 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 767453005295 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 767453005296 active site 767453005297 8-oxo-dGMP binding site [chemical binding]; other site 767453005298 nudix motif; other site 767453005299 metal binding site [ion binding]; metal-binding site 767453005300 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 767453005301 active site 767453005302 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 767453005303 active site 767453005304 substrate binding site [chemical binding]; other site 767453005305 trimer interface [polypeptide binding]; other site 767453005306 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 767453005307 CoA binding site [chemical binding]; other site 767453005308 argininosuccinate lyase; Provisional; Region: PRK00855 767453005309 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 767453005310 active sites [active] 767453005311 tetramer interface [polypeptide binding]; other site 767453005312 argininosuccinate synthase; Provisional; Region: PRK13820 767453005313 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 767453005314 ANP binding site [chemical binding]; other site 767453005315 Substrate Binding Site II [chemical binding]; other site 767453005316 Substrate Binding Site I [chemical binding]; other site 767453005317 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 767453005318 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767453005319 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767453005320 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767453005321 Walker A/P-loop; other site 767453005322 ATP binding site [chemical binding]; other site 767453005323 Q-loop/lid; other site 767453005324 ABC transporter signature motif; other site 767453005325 Walker B; other site 767453005326 D-loop; other site 767453005327 H-loop/switch region; other site 767453005328 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 767453005329 FtsX-like permease family; Region: FtsX; pfam02687 767453005330 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 767453005331 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 767453005332 FtsX-like permease family; Region: FtsX; pfam02687 767453005333 Rib/alpha-like repeat; Region: Rib; pfam08428 767453005334 Rib/alpha-like repeat; Region: Rib; pfam08428 767453005335 ApbE family; Region: ApbE; pfam02424 767453005336 FMN-binding domain; Region: FMN_bind; cl01081 767453005337 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767453005338 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767453005339 Walker A/P-loop; other site 767453005340 ATP binding site [chemical binding]; other site 767453005341 Q-loop/lid; other site 767453005342 ABC transporter signature motif; other site 767453005343 Walker B; other site 767453005344 D-loop; other site 767453005345 H-loop/switch region; other site 767453005346 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 767453005347 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 767453005348 FtsX-like permease family; Region: FtsX; pfam02687 767453005349 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767453005350 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767453005351 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 767453005352 TPP-binding site; other site 767453005353 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 767453005354 hypothetical protein; Provisional; Region: PRK00967 767453005355 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453005356 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453005357 Probable transposase; Region: OrfB_IS605; pfam01385 767453005358 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453005359 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453005360 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 767453005361 active site 767453005362 Mn binding site [ion binding]; other site 767453005363 Nitronate monooxygenase; Region: NMO; pfam03060 767453005364 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 767453005365 FMN binding site [chemical binding]; other site 767453005366 substrate binding site [chemical binding]; other site 767453005367 putative catalytic residue [active] 767453005368 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767453005369 dimerization interface [polypeptide binding]; other site 767453005370 putative DNA binding site [nucleotide binding]; other site 767453005371 putative Zn2+ binding site [ion binding]; other site 767453005372 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 767453005373 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 767453005374 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767453005375 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 767453005376 Soluble P-type ATPase [General function prediction only]; Region: COG4087 767453005377 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 767453005378 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 767453005379 GMP synthase; Reviewed; Region: guaA; PRK00074 767453005380 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 767453005381 AMP/PPi binding site [chemical binding]; other site 767453005382 candidate oxyanion hole; other site 767453005383 catalytic triad [active] 767453005384 potential glutamine specificity residues [chemical binding]; other site 767453005385 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 767453005386 ATP Binding subdomain [chemical binding]; other site 767453005387 Ligand Binding sites [chemical binding]; other site 767453005388 Dimerization subdomain; other site 767453005389 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 767453005390 synthetase active site [active] 767453005391 NTP binding site [chemical binding]; other site 767453005392 metal binding site [ion binding]; metal-binding site 767453005393 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 767453005394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 767453005395 active site 767453005396 phosphorylation site [posttranslational modification] 767453005397 intermolecular recognition site; other site 767453005398 dimerization interface [polypeptide binding]; other site 767453005399 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 767453005400 DNA binding site [nucleotide binding] 767453005401 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 767453005402 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 767453005403 dimer interface [polypeptide binding]; other site 767453005404 phosphorylation site [posttranslational modification] 767453005405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 767453005406 ATP binding site [chemical binding]; other site 767453005407 Mg2+ binding site [ion binding]; other site 767453005408 G-X-G motif; other site 767453005409 pantothenate kinase; Provisional; Region: PRK05439 767453005410 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 767453005411 ATP-binding site [chemical binding]; other site 767453005412 CoA-binding site [chemical binding]; other site 767453005413 Mg2+-binding site [ion binding]; other site 767453005414 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 767453005415 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 767453005416 Coenzyme A binding pocket [chemical binding]; other site 767453005417 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 767453005418 Sulfatase; Region: Sulfatase; pfam00884 767453005419 EamA-like transporter family; Region: EamA; pfam00892 767453005420 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 767453005421 EamA-like transporter family; Region: EamA; pfam00892 767453005422 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 767453005423 Part of AAA domain; Region: AAA_19; pfam13245 767453005424 Family description; Region: UvrD_C_2; pfam13538 767453005425 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 767453005426 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 767453005427 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767453005428 catalytic core [active] 767453005429 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 767453005430 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 767453005431 HflX GTPase family; Region: HflX; cd01878 767453005432 G1 box; other site 767453005433 GTP/Mg2+ binding site [chemical binding]; other site 767453005434 Switch I region; other site 767453005435 G2 box; other site 767453005436 G3 box; other site 767453005437 Switch II region; other site 767453005438 G4 box; other site 767453005439 G5 box; other site 767453005440 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 767453005441 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 767453005442 active site 767453005443 octamer interface [polypeptide binding]; other site 767453005444 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 767453005445 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 767453005446 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 767453005447 Coenzyme A binding pocket [chemical binding]; other site 767453005448 Predicted membrane protein [Function unknown]; Region: COG1511 767453005449 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 767453005450 Predicted membrane protein [Function unknown]; Region: COG1511 767453005451 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 767453005452 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 767453005453 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767453005454 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767453005455 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 767453005456 active site 767453005457 catalytic residues [active] 767453005458 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 767453005459 metal binding site 2 [ion binding]; metal-binding site 767453005460 putative DNA binding helix; other site 767453005461 metal binding site 1 [ion binding]; metal-binding site 767453005462 dimer interface [polypeptide binding]; other site 767453005463 structural Zn2+ binding site [ion binding]; other site 767453005464 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 767453005465 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 767453005466 catalytic site [active] 767453005467 G-X2-G-X-G-K; other site 767453005468 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 767453005469 active site 767453005470 Ap4A binding cleft/pocket [chemical binding]; other site 767453005471 P4 phosphate binding site; other site 767453005472 nudix motif; other site 767453005473 putative P2/P3 phosphate binding site [ion binding]; other site 767453005474 amino acid transporter; Region: 2A0306; TIGR00909 767453005475 Spore germination protein; Region: Spore_permease; cl17796 767453005476 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 767453005477 Probable transposase; Region: OrfB_IS605; pfam01385 767453005478 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453005479 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767453005480 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767453005481 MULE transposase domain; Region: MULE; pfam10551 767453005482 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453005483 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453005484 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 767453005485 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696 767453005486 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 767453005487 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 767453005488 TAP-like protein; Region: Abhydrolase_4; pfam08386 767453005489 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 767453005490 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767453005491 motif II; other site 767453005492 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 767453005493 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 767453005494 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 767453005495 dimer interface [polypeptide binding]; other site 767453005496 putative radical transfer pathway; other site 767453005497 diiron center [ion binding]; other site 767453005498 tyrosyl radical; other site 767453005499 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 767453005500 dinuclear metal binding motif [ion binding]; other site 767453005501 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 767453005502 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 767453005503 Class I ribonucleotide reductase; Region: RNR_I; cd01679 767453005504 active site 767453005505 dimer interface [polypeptide binding]; other site 767453005506 catalytic residues [active] 767453005507 effector binding site; other site 767453005508 R2 peptide binding site; other site 767453005509 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 767453005510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 767453005511 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 767453005512 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 767453005513 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 767453005514 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767453005515 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767453005516 ABC transporter; Region: ABC_tran_2; pfam12848 767453005517 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 767453005518 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 767453005519 zinc binding site [ion binding]; other site 767453005520 putative ligand binding site [chemical binding]; other site 767453005521 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 767453005522 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 767453005523 TM-ABC transporter signature motif; other site 767453005524 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 767453005525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767453005526 Walker A/P-loop; other site 767453005527 ATP binding site [chemical binding]; other site 767453005528 Q-loop/lid; other site 767453005529 ABC transporter signature motif; other site 767453005530 Walker B; other site 767453005531 D-loop; other site 767453005532 H-loop/switch region; other site 767453005533 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 767453005534 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 767453005535 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 767453005536 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 767453005537 ROK family; Region: ROK; pfam00480 767453005538 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 767453005539 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 767453005540 active site 767453005541 dimer interface [polypeptide binding]; other site 767453005542 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 767453005543 dimer interface [polypeptide binding]; other site 767453005544 active site 767453005545 Transcriptional regulators [Transcription]; Region: PurR; COG1609 767453005546 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767453005547 DNA binding site [nucleotide binding] 767453005548 domain linker motif; other site 767453005549 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 767453005550 dimerization interface [polypeptide binding]; other site 767453005551 ligand binding site [chemical binding]; other site 767453005552 sodium binding site [ion binding]; other site 767453005553 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 767453005554 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 767453005555 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 767453005556 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 767453005557 substrate binding site [chemical binding]; other site 767453005558 dimer interface [polypeptide binding]; other site 767453005559 ATP binding site [chemical binding]; other site 767453005560 Probable transposase; Region: OrfB_IS605; pfam01385 767453005561 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453005562 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 767453005563 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453005564 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 767453005565 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 767453005566 catalytic residues [active] 767453005567 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 767453005568 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 767453005569 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 767453005570 active site 767453005571 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 767453005572 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 767453005573 Cl binding site [ion binding]; other site 767453005574 oligomer interface [polypeptide binding]; other site 767453005575 xanthine permease; Region: pbuX; TIGR03173 767453005576 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 767453005577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 767453005578 NAD(P) binding site [chemical binding]; other site 767453005579 active site 767453005580 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 767453005581 catalytic core [active] 767453005582 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 767453005583 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 767453005584 Sulfatase; Region: Sulfatase; pfam00884 767453005585 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 767453005586 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 767453005587 ligand binding site [chemical binding]; other site 767453005588 flexible hinge region; other site 767453005589 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 767453005590 putative switch regulator; other site 767453005591 non-specific DNA interactions [nucleotide binding]; other site 767453005592 DNA binding site [nucleotide binding] 767453005593 sequence specific DNA binding site [nucleotide binding]; other site 767453005594 putative cAMP binding site [chemical binding]; other site 767453005595 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 767453005596 dinuclear metal binding motif [ion binding]; other site 767453005597 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 767453005598 metal-binding site [ion binding] 767453005599 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 767453005600 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767453005601 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 767453005602 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 767453005603 Soluble P-type ATPase [General function prediction only]; Region: COG4087 767453005604 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 767453005605 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 767453005606 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 767453005607 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 767453005608 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 767453005609 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 767453005610 active site 767453005611 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 767453005612 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 767453005613 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 767453005614 Walker A/P-loop; other site 767453005615 ATP binding site [chemical binding]; other site 767453005616 Q-loop/lid; other site 767453005617 ABC transporter signature motif; other site 767453005618 Walker B; other site 767453005619 D-loop; other site 767453005620 H-loop/switch region; other site 767453005621 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 767453005622 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 767453005623 Walker A/P-loop; other site 767453005624 ATP binding site [chemical binding]; other site 767453005625 Q-loop/lid; other site 767453005626 ABC transporter signature motif; other site 767453005627 Walker B; other site 767453005628 D-loop; other site 767453005629 H-loop/switch region; other site 767453005630 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 767453005631 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 767453005632 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 767453005633 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 767453005634 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 767453005635 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 767453005636 OsmC-like protein; Region: OsmC; cl00767 767453005637 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 767453005638 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 767453005639 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 767453005640 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 767453005641 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 767453005642 non-specific DNA binding site [nucleotide binding]; other site 767453005643 salt bridge; other site 767453005644 sequence-specific DNA binding site [nucleotide binding]; other site 767453005645 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 767453005646 Ligand Binding Site [chemical binding]; other site 767453005647 ANTAR domain; Region: ANTAR; cl04297 767453005648 HflC protein; Region: hflC; TIGR01932 767453005649 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 767453005650 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 767453005651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453005652 putative substrate translocation pore; other site 767453005653 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 767453005654 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 767453005655 TPP-binding site [chemical binding]; other site 767453005656 dimer interface [polypeptide binding]; other site 767453005657 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 767453005658 PYR/PP interface [polypeptide binding]; other site 767453005659 dimer interface [polypeptide binding]; other site 767453005660 TPP binding site [chemical binding]; other site 767453005661 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 767453005662 putative translaldolase; Provisional; Region: PRK12376 767453005663 catalytic residue [active] 767453005664 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 767453005665 tetramer (dimer of dimers) interface [polypeptide binding]; other site 767453005666 active site 767453005667 dimer interface [polypeptide binding]; other site 767453005668 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 767453005669 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 767453005670 PYR/PP interface [polypeptide binding]; other site 767453005671 dimer interface [polypeptide binding]; other site 767453005672 TPP binding site [chemical binding]; other site 767453005673 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 767453005674 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767453005675 MULE transposase domain; Region: MULE; pfam10551 767453005676 High-affinity nickel-transport protein; Region: NicO; cl00964 767453005677 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 767453005678 amphipathic channel; other site 767453005679 Asn-Pro-Ala signature motifs; other site 767453005680 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 767453005681 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 767453005682 Ligand Binding Site [chemical binding]; other site 767453005683 Protein of unknown function DUF111; Region: DUF111; pfam01969 767453005684 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 767453005685 AIR carboxylase; Region: AIRC; smart01001 767453005686 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 767453005687 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 767453005688 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 767453005689 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 767453005690 putative switch regulator; other site 767453005691 non-specific DNA interactions [nucleotide binding]; other site 767453005692 DNA binding site [nucleotide binding] 767453005693 sequence specific DNA binding site [nucleotide binding]; other site 767453005694 putative cAMP binding site [chemical binding]; other site 767453005695 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 767453005696 Helix-turn-helix domain; Region: HTH_38; pfam13936 767453005697 Homeodomain-like domain; Region: HTH_32; pfam13565 767453005698 Integrase core domain; Region: rve; pfam00665 767453005699 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 767453005700 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 767453005701 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 767453005702 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 767453005703 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 767453005704 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 767453005705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453005706 putative substrate translocation pore; other site 767453005707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453005708 D-ribose pyranase; Provisional; Region: PRK11797 767453005709 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 767453005710 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 767453005711 substrate binding site [chemical binding]; other site 767453005712 dimer interface [polypeptide binding]; other site 767453005713 ATP binding site [chemical binding]; other site 767453005714 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 767453005715 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 767453005716 DNA-binding interface [nucleotide binding]; DNA binding site 767453005717 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 767453005718 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 767453005719 intersubunit interface [polypeptide binding]; other site 767453005720 active site 767453005721 catalytic residue [active] 767453005722 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 767453005723 active site 767453005724 catalytic residues [active] 767453005725 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 767453005726 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 767453005727 substrate binding site [chemical binding]; other site 767453005728 dimer interface [polypeptide binding]; other site 767453005729 ATP binding site [chemical binding]; other site 767453005730 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 767453005731 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 767453005732 Transcriptional regulators [Transcription]; Region: PurR; COG1609 767453005733 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767453005734 DNA binding site [nucleotide binding] 767453005735 domain linker motif; other site 767453005736 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 767453005737 inner membrane transporter YjeM; Provisional; Region: PRK15238 767453005738 putative phosphoketolase; Provisional; Region: PRK05261 767453005739 XFP N-terminal domain; Region: XFP_N; pfam09364 767453005740 XFP C-terminal domain; Region: XFP_C; pfam09363 767453005741 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 767453005742 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 767453005743 active site 767453005744 motif I; other site 767453005745 motif II; other site 767453005746 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 767453005747 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 767453005748 DNA-binding site [nucleotide binding]; DNA binding site 767453005749 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 767453005750 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 767453005751 putative deacylase active site [active] 767453005752 Peptidase family C69; Region: Peptidase_C69; pfam03577 767453005753 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 767453005754 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 767453005755 Domain of unknown function DUF21; Region: DUF21; pfam01595 767453005756 FOG: CBS domain [General function prediction only]; Region: COG0517 767453005757 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 767453005758 Transporter associated domain; Region: CorC_HlyC; smart01091 767453005759 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 767453005760 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 767453005761 dimer interface [polypeptide binding]; other site 767453005762 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 767453005763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453005764 putative substrate translocation pore; other site 767453005765 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 767453005766 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 767453005767 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 767453005768 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 767453005769 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 767453005770 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 767453005771 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 767453005772 Ligand Binding Site [chemical binding]; other site 767453005773 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 767453005774 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 767453005775 putative DNA binding site [nucleotide binding]; other site 767453005776 putative Zn2+ binding site [ion binding]; other site 767453005777 AsnC family; Region: AsnC_trans_reg; pfam01037 767453005778 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 767453005779 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 767453005780 NADP binding site [chemical binding]; other site 767453005781 homodimer interface [polypeptide binding]; other site 767453005782 active site 767453005783 Transcriptional regulators [Transcription]; Region: PurR; COG1609 767453005784 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767453005785 DNA binding site [nucleotide binding] 767453005786 domain linker motif; other site 767453005787 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 767453005788 putative dimerization interface [polypeptide binding]; other site 767453005789 putative ligand binding site [chemical binding]; other site 767453005790 oligoendopeptidase F; Region: pepF; TIGR00181 767453005791 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 767453005792 active site 767453005793 Zn binding site [ion binding]; other site 767453005794 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 767453005795 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 767453005796 Predicted membrane protein [Function unknown]; Region: COG2364 767453005797 Integrase core domain; Region: rve; pfam00665 767453005798 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767453005799 Transposase; Region: HTH_Tnp_1; pfam01527 767453005800 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 767453005801 HTH-like domain; Region: HTH_21; pfam13276 767453005802 Integrase core domain; Region: rve; pfam00665 767453005803 Integrase core domain; Region: rve_3; cl15866 767453005804 D-lactate dehydrogenase; Provisional; Region: PRK11183 767453005805 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 767453005806 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767453005807 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767453005808 Walker A/P-loop; other site 767453005809 ATP binding site [chemical binding]; other site 767453005810 Q-loop/lid; other site 767453005811 ABC transporter signature motif; other site 767453005812 Walker B; other site 767453005813 D-loop; other site 767453005814 H-loop/switch region; other site 767453005815 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 767453005816 Transposase; Region: HTH_Tnp_1; cl17663 767453005817 Helix-turn-helix domain; Region: HTH_28; pfam13518 767453005818 HTH-like domain; Region: HTH_21; pfam13276 767453005819 Integrase core domain; Region: rve; pfam00665 767453005820 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 767453005821 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 767453005822 active site 767453005823 FMN binding site [chemical binding]; other site 767453005824 substrate binding site [chemical binding]; other site 767453005825 putative catalytic residue [active] 767453005826 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 767453005827 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767453005828 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767453005829 Integrase core domain; Region: rve; pfam00665 767453005830 Integrase core domain; Region: rve_3; cl15866 767453005831 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 767453005832 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 767453005833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 767453005834 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 767453005835 Sel1 repeat; Region: Sel1; cl02723 767453005836 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 767453005837 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767453005838 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 767453005839 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 767453005840 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 767453005841 Melibiase; Region: Melibiase; pfam02065 767453005842 Transposase, Mutator family; Region: Transposase_mut; pfam00872 767453005843 MULE transposase domain; Region: MULE; pfam10551 767453005844 HTH-like domain; Region: HTH_21; pfam13276 767453005845 Integrase core domain; Region: rve; pfam00665 767453005846 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 767453005847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 767453005848 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 767453005849 HPr interaction site; other site 767453005850 glycerol kinase (GK) interaction site [polypeptide binding]; other site 767453005851 active site 767453005852 phosphorylation site [posttranslational modification] 767453005853 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 767453005854 Melibiase; Region: Melibiase; pfam02065 767453005855 Transcriptional regulators [Transcription]; Region: PurR; COG1609 767453005856 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767453005857 DNA binding site [nucleotide binding] 767453005858 domain linker motif; other site 767453005859 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 767453005860 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 767453005861 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 767453005862 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 767453005863 galactokinase; Provisional; Region: PRK05322 767453005864 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 767453005865 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 767453005866 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 767453005867 active site 767453005868 catalytic triad [active] 767453005869 oxyanion hole [active] 767453005870 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 767453005871 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 767453005872 substrate binding site [chemical binding]; other site 767453005873 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 767453005874 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 767453005875 Walker A/P-loop; other site 767453005876 ATP binding site [chemical binding]; other site 767453005877 Q-loop/lid; other site 767453005878 ABC transporter signature motif; other site 767453005879 Walker B; other site 767453005880 D-loop; other site 767453005881 H-loop/switch region; other site 767453005882 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 767453005883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 767453005884 dimer interface [polypeptide binding]; other site 767453005885 conserved gate region; other site 767453005886 putative PBP binding loops; other site 767453005887 ABC-ATPase subunit interface; other site 767453005888 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 767453005889 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 767453005890 substrate binding pocket [chemical binding]; other site 767453005891 membrane-bound complex binding site; other site 767453005892 hinge residues; other site 767453005893 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 767453005894 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 767453005895 putative ligand binding site [chemical binding]; other site 767453005896 putative NAD binding site [chemical binding]; other site 767453005897 catalytic site [active] 767453005898 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 767453005899 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 767453005900 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 767453005901 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 767453005902 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 767453005903 putative ADP-ribose binding site [chemical binding]; other site 767453005904 putative active site [active] 767453005905 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 767453005906 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 767453005907 active site 767453005908 Zn binding site [ion binding]; other site 767453005909 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 767453005910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 767453005911 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 767453005912 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 767453005913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 767453005914 Walker A motif; other site 767453005915 ATP binding site [chemical binding]; other site 767453005916 Walker B motif; other site 767453005917 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 767453005918 active site 767453005919 DNA binding site [nucleotide binding] 767453005920 Uncharacterized conserved protein [Function unknown]; Region: COG3189 767453005921 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 767453005922 Uncharacterized conserved protein [Function unknown]; Region: COG0062 767453005923 elongation factor P; Validated; Region: PRK00529 767453005924 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 767453005925 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 767453005926 RNA binding site [nucleotide binding]; other site 767453005927 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 767453005928 RNA binding site [nucleotide binding]; other site 767453005929 Transcriptional regulators [Transcription]; Region: PurR; COG1609 767453005930 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 767453005931 DNA binding site [nucleotide binding] 767453005932 domain linker motif; other site 767453005933 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 767453005934 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 767453005935 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 767453005936 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767453005937 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767453005938 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 767453005939 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 767453005940 dimerization interface [polypeptide binding]; other site 767453005941 putative DNA binding site [nucleotide binding]; other site 767453005942 putative Zn2+ binding site [ion binding]; other site 767453005943 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453005944 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453005945 Probable transposase; Region: OrfB_IS605; pfam01385 767453005946 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453005947 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453005948 Arginine repressor [Transcription]; Region: ArgR; COG1438 767453005949 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 767453005950 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 767453005951 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 767453005952 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 767453005953 Walker A/P-loop; other site 767453005954 ATP binding site [chemical binding]; other site 767453005955 Q-loop/lid; other site 767453005956 ABC transporter signature motif; other site 767453005957 Walker B; other site 767453005958 D-loop; other site 767453005959 H-loop/switch region; other site 767453005960 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 767453005961 FtsX-like permease family; Region: FtsX; pfam02687 767453005962 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 767453005963 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 767453005964 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 767453005965 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 767453005966 putative NAD(P) binding site [chemical binding]; other site 767453005967 catalytic Zn binding site [ion binding]; other site 767453005968 manganese transport protein MntH; Reviewed; Region: PRK00701 767453005969 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 767453005970 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 767453005971 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 767453005972 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 767453005973 active site 767453005974 dimer interface [polypeptide binding]; other site 767453005975 motif 1; other site 767453005976 motif 2; other site 767453005977 motif 3; other site 767453005978 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 767453005979 anticodon binding site; other site 767453005980 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 767453005981 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 767453005982 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 767453005983 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453005984 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453005985 Probable transposase; Region: OrfB_IS605; pfam01385 767453005986 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453005987 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453005988 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 767453005989 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 767453005990 Catalytic site [active] 767453005991 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 767453005992 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 767453005993 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 767453005994 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767453005995 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767453005996 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 767453005997 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 767453005998 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 767453005999 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 767453006000 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 767453006001 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 767453006002 active site 767453006003 dimer interface [polypeptide binding]; other site 767453006004 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 767453006005 Ligand Binding Site [chemical binding]; other site 767453006006 Molecular Tunnel; other site 767453006007 lysine transporter; Provisional; Region: PRK10836 767453006008 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 767453006009 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 767453006010 Transposase IS200 like; Region: Y1_Tnp; pfam01797 767453006011 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 767453006012 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 767453006013 Probable transposase; Region: OrfB_IS605; pfam01385 767453006014 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 767453006015 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 767453006016 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 767453006017 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 767453006018 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 767453006019 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 767453006020 trmE is a tRNA modification GTPase; Region: trmE; cd04164 767453006021 G1 box; other site 767453006022 GTP/Mg2+ binding site [chemical binding]; other site 767453006023 Switch I region; other site 767453006024 G2 box; other site 767453006025 Switch II region; other site 767453006026 G3 box; other site 767453006027 G4 box; other site 767453006028 G5 box; other site 767453006029 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 767453006030 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 767453006031 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 767453006032 G-X-X-G motif; other site 767453006033 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 767453006034 RxxxH motif; other site 767453006035 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 767453006036 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 767453006037 ribonuclease P; Reviewed; Region: rnpA; PRK00499